               SEQUENCE LISTING

<110> MorphoSys AG
      Galapagos NV

<120> Antagonists of IL17C for the treatment of inflammatory disorders

<130> MS169/EP Prov

<160> 186

<170> BiSSAP 1.2

<210> 1
<211> 10
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR1

<400> 1
Gly Gly Thr Phe Ser Ile Tyr Ala Ile Ser 
1               5                   10  

<210> 2
<211> 20
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR2

<400> 2
Trp Met Gly Gly Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln 
1               5                   10                  15      
Lys Phe Gln Gly 
            20  

<210> 3
<211> 10
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR3

<400> 3
Asp Ala Thr His Ser Tyr Tyr His Asp Tyr 
1               5                   10  

<210> 4
<211> 14
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR1

<400> 4
Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Glu Thr Val Ser 
1               5                   10                  

<210> 5
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR2

<400> 5
Val Met Ile Tyr Glu Val Ser Asp Arg Pro Ser 
1               5                   10      

<210> 6
<211> 9
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR3

<400> 6
Gly Ser Phe Ala His Trp Gly Ser Trp 
1               5                   

<210> 7
<211> 112
<212> PRT
<213> synthetic construct

<220> 
<223> VL

<400> 7
Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          
Glu Thr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Val 
        35                  40                  45              
Met Ile Tyr Glu Val Ser Asp Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Phe Ala His Trp 
                85                  90                  95      
Gly Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         



<210> 8
<211> 119
<212> PRT
<213> synthetic construct

<220> 
<223> VH

<400> 8
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Ala Thr His Ser Tyr Tyr His Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210> 9
<211> 336
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..336
<223> /mol_type="unassigned DNA"
      /note="VL (DNA)"
      /organism="Artificial Sequence"

<400> 9
gatatcgcgc tgacccagcc ggcgagcgtg agcggtagcc cgggccagag cattaccatt      60

agctgcaccg gcaccagcag cgatgtgggc tcttacgaaa ctgtgtcttg gtaccagcag     120

catccgggca aggcgccgaa agttatgatc tacgaagttt ctgaccgtcc gagcggcgtg     180

agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg     240

caagcggaag acgaagcgga ttattactgc ggttctttcg ctcattgggg ttcttgggtg     300

tttggcggcg gcacgaagtt aaccgttctt ggccag                               336


<210> 10
<211> 357
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..357
<223> /mol_type="unassigned DNA"
      /note="VH (DNA)"
      /organism="Artificial Sequence"

<400> 10
caggtgcaat tggtgcagag cggtgccgaa gtgaaaaaac cgggcagcag cgtgaaagtt      60

agctgcaaag catccggagg gacgttttct atctacgcta tctcttgggt gcgccaggcc     120

ccgggccagg gcctcgagtg gatgggcggt atcatcccga tcctgggcat cgcgaactac     180

gcccagaaat ttcagggccg ggtgaccatt accgccgatg aaagcaccag caccgcctat     240

atggaactga gcagcctgcg cagcgaagat acggccgtgt attattgcgc gcgtgacgct     300

actcattctt actaccatga ttactggggc caaggcaccc tggtgactgt tagctca        357


<210> 11
<211> 10
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR1

<400> 11
Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser 
1               5                   10  

<210> 12
<211> 20
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR2

<400> 12
Trp Met Gly Met Ile Met Pro Glu Val Gly Met Ala Asp Tyr Ala Gln 
1               5                   10                  15      
Lys Phe Gln Gly 
            20  

<210> 13
<211> 19
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR3

<400> 13
Asp Phe Ile Ala Val Gly Ser Leu Glu Ile Trp His Tyr Tyr Tyr Gly 
1               5                   10                  15      
Leu Asp Val 
            

<210> 14
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR1

<400> 14
Ser Gly Asp Asn Ile Gly Glu His Tyr Ala Ser 
1               5                   10      

<210> 15
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR2

<400> 15
Leu Val Ile Ser Tyr Asp Asn Glu Arg Pro Ser 
1               5                   10      

<210> 16
<211> 10
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR3

<400> 16
Gln Ser Trp Thr Ser Gln Lys Pro Asp Tyr 
1               5                   10  

<210> 17
<211> 110
<212> PRT
<213> synthetic construct

<220> 
<223> VL

<400> 17
Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      
Thr Ala Ser Ile Thr Cys Ser Gly Asp Asn Ile Gly Glu His Tyr Ala 
            20                  25                  30          
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Ser 
        35                  40                  45              
Tyr Asp Asn Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Trp Thr Ser Gln Lys Pro Asp 
                85                  90                  95      
Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110 

<210> 18
<211> 128
<212> PRT
<213> synthetic construct

<220> 
<223> VH

<400> 18
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Met Ile Met Pro Glu Val Gly Met Ala Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Phe Ile Ala Val Gly Ser Leu Glu Ile Trp His Tyr Tyr 
            100                 105                 110         
Tyr Gly Leu Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             



<210> 19
<211> 330
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..330
<223> /mol_type="unassigned DNA"
      /note="VL (DNA)"
      /organism="Artificial Sequence"

<400> 19
gatatcgaac tgacccagcc gccgagcgtg agcgtgagcc cgggccagac cgcgagcatt      60

acctgtagcg gcgataacat cggtgaacat tacgcttctt ggtaccagca gaaaccgggc     120

caggcgccgg tgctggtgat ctcttacgac aacgaacgtc cgagcggcat cccggaacgt     180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac ccaggcggaa     240

gacgaagcgg attattactg ccagtcttgg acttctcaga aaccggacta cgtgtttggc     300

ggcggcacga agttaaccgt tcttggccag                                      330


<210> 20
<211> 384
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..384
<223> /mol_type="unassigned DNA"
      /note="VH (DNA)"
      /organism="Artificial Sequence"

<400> 20
caggtgcaat tggtgcagag cggtgccgaa gtgaaaaaac cgggcagcag cgtgaaagtt      60

agctgcaaag catccggagg gacgtttagc agctatgcga ttagctgggt gcgccaggcc     120

ccgggccagg gcctcgagtg gatgggcatg atcatgccgg aagttggcat ggctgactac     180

gcccagaaat ttcagggccg ggtgaccatt accgccgatg aaagcaccag caccgcctat     240

atggaactga gcagcctgcg cagcgaagat acggccgtgt attattgcgc gcgtgacttc     300

atcgctgttg gttctctgga aatctggcat tactactacg gtctggatgt ttggggccaa     360

ggcaccctgg tgactgttag ctca                                            384


<210> 21
<211> 10
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR1

<400> 21
Gly Gly Thr Phe Ser Ser Tyr Gly Ile Ser 
1               5                   10  

<210> 22
<211> 20
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR2

<400> 22
Trp Met Gly Arg Ile Ile Pro Ile Phe Gly Thr Ala Tyr Tyr Ala Gln 
1               5                   10                  15      
Lys Phe Gln Gly 
            20  

<210> 23
<211> 19
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR3

<400> 23
Asp Met Arg Tyr His Asp Tyr Trp Pro Tyr Tyr Tyr Gly Ser Asp Gln 
1               5                   10                  15      
Phe Asp Val 
            

<210> 24
<211> 13
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR1

<400> 24
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asp Ile Val Ser 
1               5                   10              

<210> 25
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR2

<400> 25
Leu Leu Ile Tyr Tyr Asn Asn Leu Arg Pro Ser 
1               5                   10      

<210> 26
<211> 10
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR3

<400> 26
Gln Ser Trp Asp Trp Ala Ser Leu Ala Met 
1               5                   10  

<210> 27
<211> 112
<212> PRT
<213> synthetic construct

<220> 
<223> VL

<400> 27
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asp 
            20                  25                  30          
Ile Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Tyr Asn Asn Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Trp Asp Trp Ala Ser 
                85                  90                  95      
Leu Ala Met Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         



<210> 28
<211> 128
<212> PRT
<213> synthetic construct

<220> 
<223> VH

<400> 28
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Ile Pro Ile Phe Gly Thr Ala Tyr Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Met Arg Tyr His Asp Tyr Trp Pro Tyr Tyr Tyr Gly Ser 
            100                 105                 110         
Asp Gln Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             



<210> 29
<211> 336
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..336
<223> /mol_type="unassigned DNA"
      /note="VL (DNA)"
      /organism="Artificial Sequence"

<400> 29
gatatcgtgc tgacccagcc gccgagcgtg agcggtgcac cgggccagcg cgtgaccatt      60

agctgtagcg gcagcagcag caacattggt tctgacatcg tgtcttggta ccagcagctg     120

ccgggcacgg cgccgaaact gctgatctac tacaacaacc tgcgcccgag cggcgtgccg     180

gatcgcttta gcggatccaa aagcggcacc agcgccagcc tggcgattac cggcctgcaa     240

gcagaagacg aagcggatta ttactgccag tcttgggact gggcttctct ggctatggtg     300

tttggcggcg gcacgaagtt aaccgttctt ggccag                               336


<210> 30
<211> 384
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..384
<223> /mol_type="unassigned DNA"
      /note="VH (DNA)"
      /organism="Artificial Sequence"

<400> 30
caggtgcaat tggtgcagag cggtgccgaa gtgaaaaaac cgggcagcag cgtgaaagtt      60

agctgcaaag catccggagg gacgttttct tcttacggta tctcttgggt gcgccaggcc     120

ccgggccagg gcctcgagtg gatgggccgt atcatcccga tcttcggcac tgcgtactac     180

gcccagaaat ttcagggccg ggtgaccatt accgccgatg aaagcaccag caccgcctat     240

atggaactga gcagcctgcg cagcgaagat acggccgtgt attattgcgc gcgtgacatg     300

cgttaccatg actactggcc gtactactac ggttctgacc agttcgatgt ttggggccaa     360

ggcaccctgg tgactgttag ctca                                            384


<210> 31
<211> 10
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR1

<400> 31
Gly Tyr Thr Phe Thr Ser Asn Phe Ile His 
1               5                   10  

<210> 32
<211> 20
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR2

<400> 32
Trp Met Gly Trp Ile Ser Pro Tyr Asn Gly Asp Thr Asn Tyr Ala Gln 
1               5                   10                  15      
Lys Phe Gln Gly 
            20  

<210> 33
<211> 16
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR3

<400> 33
Glu Ser Val Tyr Tyr Gly Ser Asp Tyr Gly Tyr Asn Gly Met Asp Ile 
1               5                   10                  15      



<210> 34
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR1

<400> 34
Ser Gly Asp Asn Leu Gly Glu Glu Tyr Val Ser 
1               5                   10      

<210> 35
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR2

<400> 35
Leu Val Ile Tyr Asp Asp Thr Lys Arg Pro Ser 
1               5                   10      

<210> 36
<211> 9
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR3

<400> 36
Ala Ser Trp Asp Leu Trp Ser Val Glu 
1               5                   

<210> 37
<211> 109
<212> PRT
<213> synthetic construct

<220> 
<223> VL

<400> 37
Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      
Thr Ala Ser Ile Thr Cys Ser Gly Asp Asn Leu Gly Glu Glu Tyr Val 
            20                  25                  30          
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              
Asp Asp Thr Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Leu Trp Ser Val Glu 
                85                  90                  95      
Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 

<210> 38
<211> 125
<212> PRT
<213> synthetic construct

<220> 
<223> VH

<400> 38
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          
Phe Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Ser Pro Tyr Asn Gly Asp Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Ser Val Tyr Tyr Gly Ser Asp Tyr Gly Tyr Asn Gly Met 
            100                 105                 110         
Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210> 39
<211> 327
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..327
<223> /mol_type="unassigned DNA"
      /note="VL (DNA)"
      /organism="Artificial Sequence"

<400> 39
gatatcgaac tgacccagcc gccgagcgtg agcgtgagcc cgggccagac cgcgagcatt      60

acctgtagcg gcgataacct gggtgaagaa tacgtttctt ggtaccagca gaaaccgggc     120

caggcgccgg tgctggtgat ctacgacgac actaaacgtc cgagcggcat cccggaacgt     180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac ccaggcggaa     240

gacgaagcgg attattactg cgcttcttgg gacctgtggt ctgttgaagt gtttggcggc     300

ggcacgaagt taaccgttct tggccag                                         327


<210> 40
<211> 375
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..375
<223> /mol_type="unassigned DNA"
      /note="VH (DNA)"
      /organism="Artificial Sequence"

<400> 40
caggtgcaat tggtgcagag cggtgcggaa gtgaaaaaac cgggtgccag cgtgaaagtt      60

agctgcaaag cgtccggata taccttcact tctaacttca tccattgggt gcgccaggcc     120

ccgggccagg gcctcgagtg gatgggctgg atctctccgt acaacggcga cacgaactac     180

gcgcagaaat ttcagggccg ggtgaccatg acccgtgata ccagcattag caccgcgtat     240

atggaactga gccgtctgcg tagcgaagat acggccgtgt attattgcgc gcgtgaatct     300

gtttactacg gttctgacta cggttacaac ggtatggata tctggggcca aggcaccctg     360

gtgactgtta gctca                                                      375


<210> 41
<211> 10
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR1

<400> 41
Gly Tyr Thr Phe Thr Ser Asn Phe Ile His 
1               5                   10  

<210> 42
<211> 20
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR2

<400> 42
Trp Met Gly Trp Ile Ser Pro Tyr Asn Gly Asp Thr Asn Tyr Ala Gln 
1               5                   10                  15      
Lys Phe Gln Gly 
            20  

<210> 43
<211> 16
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR3

<400> 43
Glu Ser Val Tyr Tyr Gly Ser Asp Tyr Gly Tyr Asn Gly Met Asp Ile 
1               5                   10                  15      



<210> 44
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR1

<400> 44
Ser Gly Asp Asn Leu Gly Glu Glu Tyr Val Ser 
1               5                   10      

<210> 45
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR2

<400> 45
Leu Val Ile Tyr Asp Asp Thr Lys Arg Pro Ser 
1               5                   10      

<210> 46
<211> 9
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR3

<400> 46
Ala Ser Trp Ala Phe Tyr Ser Ser Gln 
1               5                   

<210> 47
<211> 109
<212> PRT
<213> synthetic construct

<220> 
<223> VL

<400> 47
Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      
Thr Ala Ser Ile Thr Cys Ser Gly Asp Asn Leu Gly Glu Glu Tyr Val 
            20                  25                  30          
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              
Asp Asp Thr Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Ala Phe Tyr Ser Ser Gln 
                85                  90                  95      
Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 

<210> 48
<211> 125
<212> PRT
<213> synthetic construct

<220> 
<223> VH

<400> 48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          
Phe Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Ser Pro Tyr Asn Gly Asp Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Ser Val Tyr Tyr Gly Ser Asp Tyr Gly Tyr Asn Gly Met 
            100                 105                 110         
Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210> 49
<211> 327
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..327
<223> /mol_type="unassigned DNA"
      /note="VL (DNA)"
      /organism="Artificial Sequence"

<400> 49
gatatcgaac tgacccagcc gccgagcgtg agcgtgagcc cgggccagac cgcgagcatt      60

acctgtagcg gcgataacct gggtgaagaa tacgtttctt ggtaccagca gaaaccgggc     120

caggcgccgg tgctggtgat ctacgacgac actaaacgtc cgagcggcat cccggaacgt     180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac ccaggcggaa     240

gacgaagcgg attattactg cgcttcttgg gctttctact cttctcaggt gtttggcggc     300

ggcacgaagt taaccgttct tggccag                                         327


<210> 50
<211> 375
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..375
<223> /mol_type="unassigned DNA"
      /note="VH (DNA)"
      /organism="Artificial Sequence"

<400> 50
caggtgcaat tggtgcagag cggtgcggaa gtgaaaaaac cgggtgccag cgtgaaagtt      60

agctgcaaag cgtccggata taccttcact tctaacttca tccattgggt gcgccaggcc     120

ccgggccagg gcctcgagtg gatgggctgg atctctccgt acaacggcga cacgaactac     180

gcgcagaaat ttcagggccg ggtgaccatg acccgtgata ccagcattag caccgcgtat     240

atggaactga gccgtctgcg tagcgaagat acggccgtgt attattgcgc gcgtgaatct     300

gtttactacg gttctgacta cggttacaac ggtatggata tctggggcca aggcaccctg     360

gtgactgtta gctca                                                      375


<210> 51
<211> 10
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR1

<400> 51
Gly Tyr Thr Phe Thr Ser Asn Phe Ile His 
1               5                   10  

<210> 52
<211> 20
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR2

<400> 52
Trp Met Gly Trp Ile Ser Pro Tyr Asn Gly Asp Thr Asn Tyr Ala Gln 
1               5                   10                  15      
Lys Phe Gln Gly 
            20  

<210> 53
<211> 16
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR3

<400> 53
Glu Ser Val Tyr Tyr Gly Ser Asp Tyr Gly Tyr Asn Gly Met Asp Ile 
1               5                   10                  15      



<210> 54
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR1

<400> 54
Ser Gly Asp Asn Leu Gly Glu Glu Tyr Val Ser 
1               5                   10      

<210> 55
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR2

<400> 55
Leu Val Ile Tyr Asp Asp Thr Lys Arg Pro Ser 
1               5                   10      

<210> 56
<211> 9
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR3

<400> 56
Ser Ala Trp Ala Thr Trp Ser Val Ala 
1               5                   

<210> 57
<211> 109
<212> PRT
<213> synthetic construct

<220> 
<223> VL

<400> 57
Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      
Thr Ala Ser Ile Thr Cys Ser Gly Asp Asn Leu Gly Glu Glu Tyr Val 
            20                  25                  30          
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              
Asp Asp Thr Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Ala Thr Trp Ser Val Ala 
                85                  90                  95      
Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 

<210> 58
<211> 125
<212> PRT
<213> synthetic construct

<220> 
<223> VH

<400> 58
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          
Phe Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Ser Pro Tyr Asn Gly Asp Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Ser Val Tyr Tyr Gly Ser Asp Tyr Gly Tyr Asn Gly Met 
            100                 105                 110         
Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210> 59
<211> 327
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..327
<223> /mol_type="unassigned DNA"
      /note="VL (DNA)"
      /organism="Artificial Sequence"

<400> 59
gatatcgaac tgacccagcc gccgagcgtg agcgtgagcc cgggccagac cgcgagcatt      60

acctgtagcg gcgataacct gggtgaagaa tacgtttctt ggtaccagca gaaaccgggc     120

caggcgccgg tgctggtgat ctacgacgac actaaacgtc cgagcggcat cccggaacgt     180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac ccaggcggaa     240

gacgaagcgg attattactg ctctgcttgg gctacttggt ctgttgctgt gtttggcggc     300

ggcacgaagt taaccgttct tggccag                                         327


<210> 60
<211> 375
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..375
<223> /mol_type="unassigned DNA"
      /note="VH (DNA)"
      /organism="Artificial Sequence"

<400> 60
caggtgcaat tggtgcagag cggtgcggaa gtgaaaaaac cgggtgccag cgtgaaagtt      60

agctgcaaag cgtccggata taccttcact tctaacttca tccattgggt gcgccaggcc     120

ccgggccagg gcctcgagtg gatgggctgg atctctccgt acaacggcga cacgaactac     180

gcgcagaaat ttcagggccg ggtgaccatg acccgtgata ccagcattag caccgcgtat     240

atggaactga gccgtctgcg tagcgaagat acggccgtgt attattgcgc gcgtgaatct     300

gtttactacg gttctgacta cggttacaac ggtatggata tctggggcca aggcaccctg     360

gtgactgtta gctca                                                      375


<210> 61
<211> 10
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR1

<400> 61
Gly Tyr Thr Phe Thr Ser Asn Phe Ile His 
1               5                   10  

<210> 62
<211> 20
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR2

<400> 62
Trp Met Gly Trp Ile Ser Pro Tyr Asn Gly Asp Thr Asn Tyr Ala Gln 
1               5                   10                  15      
Lys Phe Gln Gly 
            20  

<210> 63
<211> 16
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR3

<400> 63
Glu Ser Val Tyr Tyr Gly Ser Asp Tyr Gly Tyr Asn Gly Met Asp Ile 
1               5                   10                  15      



<210> 64
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR1

<400> 64
Ser Gly Asp Asn Leu Gly Glu Glu Tyr Val Ser 
1               5                   10      

<210> 65
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR2

<400> 65
Leu Val Ile Tyr Asp Asp Thr Lys Arg Pro Ser 
1               5                   10      

<210> 66
<211> 9
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR3

<400> 66
Ser Ser Trp Thr His Phe Ser Asn Ile 
1               5                   

<210> 67
<211> 109
<212> PRT
<213> synthetic construct

<220> 
<223> VL

<400> 67
Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      
Thr Ala Ser Ile Thr Cys Ser Gly Asp Asn Leu Gly Glu Glu Tyr Val 
            20                  25                  30          
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              
Asp Asp Thr Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Thr His Phe Ser Asn Ile 
                85                  90                  95      
Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 

<210> 68
<211> 125
<212> PRT
<213> synthetic construct

<220> 
<223> VH

<400> 68
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          
Phe Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Ser Pro Tyr Asn Gly Asp Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Ser Val Tyr Tyr Gly Ser Asp Tyr Gly Tyr Asn Gly Met 
            100                 105                 110         
Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210> 69
<211> 327
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..327
<223> /mol_type="unassigned DNA"
      /note="VL (DNA)"
      /organism="Artificial Sequence"

<400> 69
gatatcgaac tgacccagcc gccgagcgtg agcgtgagcc cgggccagac cgcgagcatt      60

acctgtagcg gcgataacct gggtgaagaa tacgtttctt ggtaccagca gaaaccgggc     120

caggcgccgg tgctggtgat ctacgacgac actaaacgtc cgagcggcat cccggaacgt     180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac ccaggcggaa     240

gacgaagcgg attattactg ctcttcttgg actcatttct ctaacatcgt gtttggcggc     300

ggcacgaagt taaccgttct tggccag                                         327


<210> 70
<211> 375
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..375
<223> /mol_type="unassigned DNA"
      /note="VH (DNA)"
      /organism="Artificial Sequence"

<400> 70
caggtgcaat tggtgcagag cggtgcggaa gtgaaaaaac cgggtgccag cgtgaaagtt      60

agctgcaaag cgtccggata taccttcact tctaacttca tccattgggt gcgccaggcc     120

ccgggccagg gcctcgagtg gatgggctgg atctctccgt acaacggcga cacgaactac     180

gcgcagaaat ttcagggccg ggtgaccatg acccgtgata ccagcattag caccgcgtat     240

atggaactga gccgtctgcg tagcgaagat acggccgtgt attattgcgc gcgtgaatct     300

gtttactacg gttctgacta cggttacaac ggtatggata tctggggcca aggcaccctg     360

gtgactgtta gctca                                                      375


<210> 71
<211> 12
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR1

<400> 71
Gly Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn 
1               5                   10          

<210> 72
<211> 21
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR2

<400> 72
Trp Leu Gly Val Ile Tyr Tyr Arg Ser Lys Trp Tyr Ile Asn Tyr Ala 
1               5                   10                  15      
Asp Ser Val Lys Ser 
            20      

<210> 73
<211> 10
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR3

<400> 73
Glu Gly Ile Val Gly Gly Trp Phe Ala Tyr 
1               5                   10  

<210> 74
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR1

<400> 74
Ser Gly Asp Lys Leu Gly Ser Lys Ile Ala His 
1               5                   10      

<210> 75
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR2

<400> 75
Leu Val Ile Tyr Asp Asp Asn Glu Arg Pro Ser 
1               5                   10      

<210> 76
<211> 10
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR3

<400> 76
Gln Ser Trp Asp Tyr Leu Ser Trp Ser Val 
1               5                   10  

<210> 77
<211> 110
<212> PRT
<213> synthetic construct

<220> 
<223> VL

<400> 77
Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      
Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Ser Lys Ile Ala 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              
Asp Asp Asn Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Trp Asp Tyr Leu Ser Trp Ser 
                85                  90                  95      
Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110 

<210> 78
<211> 330
<212> PRT
<213> synthetic construct

<220> 
<223> VH

<400> 78
Gly Ala Thr Ala Thr Cys Gly Ala Ala Cys Thr Gly Ala Cys Cys Cys 
1               5                   10                  15      
Ala Gly Cys Cys Gly Cys Cys Gly Ala Gly Cys Gly Thr Gly Ala Gly 
            20                  25                  30          
Cys Gly Thr Gly Ala Gly Cys Cys Cys Gly Gly Gly Cys Cys Ala Gly 
        35                  40                  45              
Ala Cys Cys Gly Cys Gly Ala Gly Cys Ala Thr Thr Ala Cys Cys Thr 
    50                  55                  60                  
Gly Thr Ala Gly Cys Gly Gly Cys Gly Ala Thr Ala Ala Ala Cys Thr 
65                  70                  75                  80  
Gly Gly Gly Thr Thr Cys Thr Ala Ala Ala Ala Thr Cys Gly Cys Thr 
                85                  90                  95      
Cys Ala Thr Thr Gly Gly Thr Ala Cys Cys Ala Gly Cys Ala Gly Ala 
            100                 105                 110         
Ala Ala Cys Cys Gly Gly Gly Cys Cys Ala Gly Gly Cys Gly Cys Cys 
        115                 120                 125             
Gly Gly Thr Gly Cys Thr Gly Gly Thr Gly Ala Thr Cys Thr Ala Cys 
    130                 135                 140                 
Gly Ala Cys Gly Ala Cys Ala Ala Cys Gly Ala Ala Cys Gly Thr Cys 
145                 150                 155                 160 
Cys Gly Ala Gly Cys Gly Gly Cys Ala Thr Cys Cys Cys Gly Gly Ala 
                165                 170                 175     
Ala Cys Gly Thr Thr Thr Thr Ala Gly Cys Gly Gly Ala Thr Cys Cys 
            180                 185                 190         
Ala Ala Cys Ala Gly Cys Gly Gly Cys Ala Ala Cys Ala Cys Cys Gly 
        195                 200                 205             
Cys Gly Ala Cys Cys Cys Thr Gly Ala Cys Cys Ala Thr Thr Ala Gly 
    210                 215                 220                 
Cys Gly Gly Cys Ala Cys Cys Cys Ala Gly Gly Cys Gly Gly Ala Ala 
225                 230                 235                 240 
Gly Ala Cys Gly Ala Ala Gly Cys Gly Gly Ala Thr Thr Ala Thr Thr 
                245                 250                 255     
Ala Cys Thr Gly Cys Cys Ala Gly Thr Cys Thr Thr Gly Gly Gly Ala 
            260                 265                 270         
Cys Thr Ala Cys Cys Thr Gly Thr Cys Thr Thr Gly Gly Thr Cys Thr 
        275                 280                 285             
Gly Thr Thr Gly Thr Gly Thr Thr Thr Gly Gly Cys Gly Gly Cys Gly 
    290                 295                 300                 
Gly Cys Ala Cys Gly Ala Ala Gly Thr Thr Ala Ala Cys Cys Gly Thr 
305                 310                 315                 320 
Thr Cys Thr Thr Gly Gly Cys Cys Ala Gly 
                325                 330 

<210> 79
<211> 330
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..330
<223> /mol_type="unassigned DNA"
      /note="VL (DNA)"
      /organism="Artificial Sequence"

<400> 79
gatatcgaac tgacccagcc gccgagcgtg agcgtgagcc cgggccagac cgcgagcatt      60

acctgtagcg gcgataaact gggttctaaa atcgctcatt ggtaccagca gaaaccgggc     120

caggcgccgg tgctggtgat ctacgacgac aacgaacgtc cgagcggcat cccggaacgt     180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac ccaggcggaa     240

gacgaagcgg attattactg ccagtcttgg gactacctgt cttggtctgt tgtgtttggc     300

ggcggcacga agttaaccgt tcttggccag                                      330


<210> 80
<211> 366
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..366
<223> /mol_type="unassigned DNA"
      /note="VH (DNA)"
      /organism="Artificial Sequence"

<400> 80
caggtgcaat tgcagcagag cggtccgggc ctggtgaaac cgagccagac cctgagcctg      60

acctgcgcga tttccggaga tagcgtgagc agtaactctg ctgcttggaa ctggattcgt     120

cagagcccga gccgtggcct cgagtggctg ggcgttatct actaccgtag caaatggtac     180

atcaactatg ccgacagcgt gaaaagccgc attaccatta acccggatac ttcgaaaaac     240

cagtttagcc tgcaactgaa cagcgtgacc ccggaagata cggccgtgta ttattgcgcg     300

cgtgaaggta tcgttggtgg ttggttcgct tactggggcc aaggcaccct ggtgactgtt     360

agctca                                                                366


<210> 81
<211> 12
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR1

<400> 81
Gly Asp Ser Val Ser Ser Ser Ser Ala Ala Trp Asn 
1               5                   10          

<210> 82
<211> 21
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR2

<400> 82
Trp Leu Gly Arg Ile Glu Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
1               5                   10                  15      
Val Ser Val Lys Ser 
            20      

<210> 83
<211> 13
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR3

<400> 83
Glu Met Tyr Tyr Tyr Ser Gly Tyr Gly Val Phe Asp Val 
1               5                   10              

<210> 84
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR1

<400> 84
Ser Gly Asp Ala Leu Gly Gly Glu Tyr Val His 
1               5                   10      

<210> 85
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR2

<400> 85
Leu Val Ile Tyr Asp Asp Asp Lys Arg Pro Ser 
1               5                   10      

<210> 86
<211> 9
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR3

<400> 86
Ser Ser Phe Asp Thr Trp Thr Ser Tyr 
1               5                   

<210> 87
<211> 109
<212> PRT
<213> synthetic construct

<220> 
<223> VL

<400> 87
Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      
Thr Ala Ser Ile Thr Cys Ser Gly Asp Ala Leu Gly Gly Glu Tyr Val 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              
Asp Asp Asp Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Phe Asp Thr Trp Thr Ser Tyr 
                85                  90                  95      
Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 

<210> 88
<211> 125
<212> PRT
<213> synthetic construct

<220> 
<223> VH

<400> 88
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Ser 
            20                  25                  30          
Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              
Trp Leu Gly Arg Ile Glu Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  
Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  
Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      
Tyr Tyr Cys Ala Arg Glu Met Tyr Tyr Tyr Ser Gly Tyr Gly Val Phe 
            100                 105                 110         
Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210> 89
<211> 327
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..327
<223> /mol_type="unassigned DNA"
      /note="VL (DNA)"
      /organism="Artificial Sequence"

<400> 89
gatatcgaac tgacccagcc gccgagcgtg agcgtgagcc cgggccagac cgcgagcatt      60

acctgtagcg gcgatgctct gggtggtgaa tacgttcatt ggtaccagca gaaaccgggc     120

caggcgccgg tgctggtgat ctacgacgac gacaaacgtc cgagcggcat cccggaacgt     180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac ccaggcggaa     240

gacgaagcgg attattactg ctcttctttc gacacttgga cttcttacgt gtttggcggc     300

ggcacgaagt taaccgttct tggccag                                         327


<210> 90
<211> 375
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..375
<223> /mol_type="unassigned DNA"
      /note="VH (DNA)"
      /organism="Artificial Sequence"

<400> 90
caggtgcaat tgcagcagag cggtccgggc ctggtgaaac cgagccagac cctgagcctg      60

acctgcgcga tttccggaga tagcgtgagc tcctcttctg ctgcttggaa ctggattcgt     120

cagagcccga gccgtggcct cgagtggctg ggccgtatcg aataccgtag caaatggtac     180

aacgactatg ccgtgagcgt gaaaagccgc attaccatta acccggatac ttcgaaaaac     240

cagtttagcc tgcaactgaa cagcgtgacc ccggaagata cggccgtgta ttattgcgcg     300

cgtgaaatgt actactactc tggttacggt gttttcgatg tttggggcca aggcaccctg     360

gtgactgtta gctca                                                      375


<210> 91
<211> 10
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR1

<400> 91
Gly Phe Thr Phe Ser Asp Tyr Ala Met Thr 
1               5                   10  

<210> 92
<211> 20
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR2

<400> 92
Trp Val Ser Val Ile Ser Tyr Asp Gly Ser Leu Thr Tyr Tyr Ala Asp 
1               5                   10                  15      
Ser Val Lys Gly 
            20  

<210> 93
<211> 12
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR3

<400> 93
Asp Pro Gly Val Trp Trp Leu Ser Tyr Leu Asp Tyr 
1               5                   10          

<210> 94
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR1

<400> 94
Arg Ala Ser Gln Asp Ile Ile Ser Tyr Leu Ala 
1               5                   10      

<210> 95
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR2

<400> 95
Leu Leu Ile Tyr Gly Ala Ser Asn Leu Gln Gly 
1               5                   10      

<210> 96
<211> 9
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR3

<400> 96
Gln Gln Tyr Met Ile Ala Pro Pro Asn 
1               5                   

<210> 97
<211> 110
<212> PRT
<213> synthetic construct

<220> 
<223> VL

<400> 97
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ile Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Asn Leu Gln Gly Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Met Ile Ala Pro Pro 
                85                  90                  95      
Asn Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 

<210> 98
<211> 121
<212> PRT
<213> synthetic construct

<220> 
<223> VH

<400> 98
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          
Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Val Ile Ser Tyr Asp Gly Ser Leu Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Pro Gly Val Trp Trp Leu Ser Tyr Leu Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 99
<211> 330
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..330
<223> /mol_type="unassigned DNA"
      /note="VL (DNA)"
      /organism="Artificial Sequence"

<400> 99
gatatccaga tgacccagag cccgagcagc ctgagcgcca gcgtgggcga tcgcgtgacc      60

attacctgca gagccagcca ggacattatc tcttacctgg cttggtacca gcagaaaccg     120

ggcaaagcgc cgaaactatt aatctacggt gcttctaacc tgcaaggcgg cgtgccgagc     180

cgctttagcg gcagcggatc cggcaccgat ttcaccctga ccattagctc tctgcaaccg     240

gaagactttg cggtgtatta ttgccagcag tacatgatcg ctccaccgaa cacctttggc     300

cagggcacga aagttgaaat taaacgtacg                                      330


<210> 100
<211> 363
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..363
<223> /mol_type="unassigned DNA"
      /note="VH (DNA)"
      /organism="Artificial Sequence"

<400> 100
gaagtgcaat tgctggaaag cggcggtggc ctggtgcagc cgggtggcag cctgcgtctg      60

agctgcgcgg cgtccggatt caccttttct gactacgcta tgacttgggt gcgccaggcc     120

ccgggcaaag gtctcgagtg ggtttccgtt atctcttacg acggttctct gacctactat     180

gcggatagcg tgaaaggccg ctttaccatc agccgcgata attcgaaaaa caccctgtat     240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtgacccg     300

ggtgtttggt ggctgtctta cctggattac tggggccaag gcaccctggt gactgttagc     360

tca                                                                   363


<210> 101
<211> 12
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR1

<400> 101
Gly Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn 
1               5                   10          

<210> 102
<211> 21
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR2

<400> 102
Trp Leu Gly Lys Thr Tyr Tyr Arg Ser Thr Trp Ser Asn Asp Tyr Ala 
1               5                   10                  15      
Glu Ser Val Lys Ser 
            20      

<210> 103
<211> 16
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR3

<400> 103
Glu Met Asp Ser Leu Thr Arg Ser Ala Ser Ser Ile Ala Phe Asp Tyr 
1               5                   10                  15      



<210> 104
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR1

<400> 104
Ser Gly Asp Asn Leu Arg Glu His Tyr Val His 
1               5                   10      

<210> 105
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR2

<400> 105
Leu Val Ile Tyr Asp Asp Thr Glu Arg Pro Ser 
1               5                   10      

<210> 106
<211> 8
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR3

<400> 106
Ala Thr Arg Asp Trp Ser Asn Val 
1               5               

<210> 107
<211> 108
<212> PRT
<213> synthetic construct

<220> 
<223> VL

<400> 107
Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      
Thr Ala Ser Ile Thr Cys Ser Gly Asp Asn Leu Arg Glu His Tyr Val 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              
Asp Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Arg Asp Trp Ser Asn Val Val 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105             

<210> 108
<211> 128
<212> PRT
<213> synthetic construct

<220> 
<223> VH

<400> 108
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          
Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              
Trp Leu Gly Lys Thr Tyr Tyr Arg Ser Thr Trp Ser Asn Asp Tyr Ala 
    50                  55                  60                  
Glu Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  
Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      
Tyr Tyr Cys Ala Arg Glu Met Asp Ser Leu Thr Arg Ser Ala Ser Ser 
            100                 105                 110         
Ile Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             



<210> 109
<211> 324
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..324
<223> /mol_type="unassigned DNA"
      /note="VL (DNA)"
      /organism="Artificial Sequence"

<400> 109
gatatcgaac tgacccagcc gccgagcgtg agcgtgagcc cgggccagac cgcgagcatt      60

acctgtagcg gcgataacct gcgtgaacat tacgttcatt ggtaccagca gaaaccgggc     120

caggcgccgg tgctggtgat ctacgacgac actgaacgtc cgagcggcat cccggaacgt     180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac ccaggcggaa     240

gacgaagcgg attattactg cgctactcgt gactggtcta acgttgtgtt tggcggcggc     300

acgaagttaa ccgttcttgg ccag                                            324


<210> 110
<211> 384
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..384
<223> /mol_type="unassigned DNA"
      /note="VH (DNA)"
      /organism="Artificial Sequence"

<400> 110
caggtgcaat tgcagcagag cggtccgggc ctggtgaaac cgagccagac cctgagcctg      60

acctgcgcga tttccggaga tagcgtgagc agtaactctg ctgcttggaa ctggattcgt     120

cagagcccga gccgtggcct cgagtggctg ggcaaaacct actaccgtag cacttggtct     180

aacgactatg ccgaaagcgt gaaaagccgc attaccatta acccggatac ttcgaaaaac     240

cagtttagcc tgcaactgaa cagcgtgacc ccggaagata cggccgtgta ttattgcgcg     300

cgtgaaatgg actctctgac tcgttctgct tcttctatcg ctttcgatta ctggggccaa     360

ggcaccctgg tgactgttag ctca                                            384


<210> 111
<211> 12
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR1

<400> 111
Gly Asp Ser Val Ser Asp Asn Ser Val Ala Trp Asn 
1               5                   10          

<210> 112
<211> 21
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR2

<400> 112
Trp Leu Gly Arg Ile Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
1               5                   10                  15      
Val Ser Val Lys Ser 
            20      

<210> 113
<211> 16
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR3

<400> 113
Glu Val Leu Leu Phe Pro Ala Arg Ser Tyr Gly Thr Gly Met Asp Val 
1               5                   10                  15      



<210> 114
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR1

<400> 114
Ser Gly Asp Asn Leu Pro Ser Lys Tyr Val His 
1               5                   10      

<210> 115
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR2

<400> 115
Leu Val Ile Tyr Asp Asp Asn Glu Arg Pro Ser 
1               5                   10      

<210> 116
<211> 10
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR3

<400> 116
Gly Val Ala Asp Met Pro Arg Gln Met Lys 
1               5                   10  

<210> 117
<211> 110
<212> PRT
<213> synthetic construct

<220> 
<223> VL

<400> 117
Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      
Thr Ala Ser Ile Thr Cys Ser Gly Asp Asn Leu Pro Ser Lys Tyr Val 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              
Asp Asp Asn Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gly Val Ala Asp Met Pro Arg Gln Met 
                85                  90                  95      
Lys Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110 

<210> 118
<211> 128
<212> PRT
<213> synthetic construct

<220> 
<223> VH

<400> 118
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Asp Asn 
            20                  25                  30          
Ser Val Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              
Trp Leu Gly Arg Ile Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  
Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  
Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      
Tyr Tyr Cys Ala Arg Glu Val Leu Leu Phe Pro Ala Arg Ser Tyr Gly 
            100                 105                 110         
Thr Gly Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             



<210> 119
<211> 330
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..330
<223> /mol_type="unassigned DNA"
      /note="VL (DNA)"
      /organism="Artificial Sequence"

<400> 119
gatatcgaac tgacccagcc gccgagcgtg agcgtgagcc cgggccagac cgcgagcatt      60

acctgtagcg gcgataacct gccgtctaaa tacgttcatt ggtaccagca gaaaccgggc     120

caggcgccgg tgctggtgat ctacgacgac aacgaacgtc cgagcggcat cccggaacgt     180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac ccaggcggaa     240

gacgaagcgg attattactg cggtgttgct gacatgccgc gtcagatgaa agtgtttggc     300

ggcggcacga agttaaccgt tcttggccag                                      330


<210> 120
<211> 384
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..384
<223> /mol_type="unassigned DNA"
      /note="VH (DNA)"
      /organism="Artificial Sequence"

<400> 120
caggtgcaat tgcagcagag cggtccgggc ctggtgaaac cgagccagac cctgagcctg      60

acctgcgcga tttccggaga tagcgtgagc gacaactctg ttgcttggaa ctggattcgt     120

cagagcccga gccgtggcct cgagtggctg ggccgtatct actaccgtag caaatggtac     180

aacgactatg ccgtgagcgt gaaaagccgc attaccatta acccggatac ttcgaaaaac     240

cagtttagcc tgcaactgaa cagcgtgacc ccggaagata cggccgtgta ttattgcgcg     300

cgtgaagttc tgctgttccc ggctcgttct tacggtactg gtatggatgt ttggggccaa     360

ggcaccctgg tgactgttag ctca                                            384


<210> 121
<211> 10
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR1

<400> 121
Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   10  

<210> 122
<211> 20
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR2

<400> 122
Trp Val Ser Phe Ile Ser Ser Gly Gly Ser Glu Thr Phe Tyr Ala Asp 
1               5                   10                  15      
Ser Val Lys Gly 
            20  

<210> 123
<211> 14
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR3

<400> 123
Val Ser Tyr Ile Tyr Tyr Tyr Ser Trp Val Leu Phe Asp Val 
1               5                   10                  

<210> 124
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR1

<400> 124
Arg Ala Ser Gln Gly Ile Gly Thr Ala Leu Asn 
1               5                   10      

<210> 125
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR2

<400> 125
Leu Leu Ile Tyr Asp Val Ser Ser Leu Gln Ser 
1               5                   10      

<210> 126
<211> 8
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR3

<400> 126
Gln Gln Gly Leu Phe Leu Pro Phe 
1               5               

<210> 127
<211> 109
<212> PRT
<213> synthetic construct

<220> 
<223> VL

<400> 127
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Thr Ala 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Asp Val Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Leu Phe Leu Pro Phe 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 

<210> 128
<211> 123
<212> PRT
<213> synthetic construct

<220> 
<223> VH

<400> 128
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Phe Ile Ser Ser Gly Gly Ser Glu Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Val Ser Tyr Ile Tyr Tyr Tyr Ser Trp Val Leu Phe Asp Val 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210> 129
<211> 327
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..327
<223> /mol_type="unassigned DNA"
      /note="VL (DNA)"
      /organism="Artificial Sequence"

<400> 129
gatatccaga tgacccagag cccgagcagc ctgagcgcca gcgtgggcga tcgcgtgacc      60

attacctgca gagccagcca gggtattggt actgctctga actggtacca gcagaaaccg     120

ggcaaagcgc cgaaactatt aatctacgac gtttcttctc tgcaaagcgg cgtgccgagc     180

cgctttagcg gcagcggatc cggcaccgat ttcaccctga ccattagctc tctgcaaccg     240

gaagactttg cgacctatta ttgccagcag ggtctgttcc tgccgttcac ctttggccag     300

ggcacgaaag ttgaaattaa acgtacg                                         327


<210> 130
<211> 369
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..369
<223> /mol_type="unassigned DNA"
      /note="VH (DNA)"
      /organism="Artificial Sequence"

<400> 130
gaagtgcaat tgctggaaag cggcggtggc ctggtgcagc cgggtggcag cctgcgtctg      60

agctgcgcgg cgtccggatt caccttttct tcttacgcta tgtcttgggt gcgccaggcc     120

ccgggcaaag gtctcgagtg ggtttccttc atctcttctg gtggttctga aaccttctat     180

gcggatagcg tgaaaggccg ctttaccatc agccgcgata attcgaaaaa caccctgtat     240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtgtttct     300

tacatctact actactcttg ggttctgttc gatgtttggg gccaaggcac cctggtgact     360

gttagctca                                                             369


<210> 131
<211> 10
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR1

<400> 131
Gly Tyr Ser Phe Thr Asp Tyr Trp Ile Ser 
1               5                   10  

<210> 132
<211> 20
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR2

<400> 132
Trp Met Gly Ala Ile Asp Pro Thr Asp Ser Tyr Thr Arg Tyr Ser Pro 
1               5                   10                  15      
Ser Phe Gln Gly 
            20  

<210> 133
<211> 16
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR3

<400> 133
Trp Tyr Thr Ser His Pro Tyr Tyr Glu Gly Arg Tyr Pro Met Asp Val 
1               5                   10                  15      



<210> 134
<211> 14
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR1

<400> 134
Thr Gly Thr Ser Ser Asp Val Gly His Tyr Asn Tyr Val Ser 
1               5                   10                  

<210> 135
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR2

<400> 135
Leu Met Ile Tyr Gly Val Thr Lys Arg Pro Ser 
1               5                   10      

<210> 136
<211> 10
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR3

<400> 136
Ala Ser Ala Asp Glu Trp Pro Thr Leu His 
1               5                   10  

<210> 137
<211> 113
<212> PRT
<213> synthetic construct

<220> 
<223> VL

<400> 137
Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly His Tyr 
            20                  25                  30          
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              
Met Ile Tyr Gly Val Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Ala Asp Glu Trp 
                85                  90                  95      
Pro Thr Leu His Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         
Gln 
    

<210> 138
<211> 125
<212> PRT
<213> synthetic construct

<220> 
<223> VH

<400> 138
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          
Trp Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Asp Pro Thr Asp Ser Tyr Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Trp Tyr Thr Ser His Pro Tyr Tyr Glu Gly Arg Tyr Pro Met 
            100                 105                 110         
Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210> 139
<211> 339
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..339
<223> /mol_type="unassigned DNA"
      /note="VL (DNA)"
      /organism="Artificial Sequence"

<400> 139
gatatcgcgc tgacccagcc ggcgagcgtg agcggtagcc cgggccagag cattaccatt      60

agctgcaccg gcaccagcag cgatgtgggc cattacaact acgtgtcttg gtaccagcag     120

catccgggca aggcgccgaa actgatgatc tacggtgtta ctaaacgtcc gagcggcgtg     180

agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg     240

caagcggaag acgaagcgga ttattactgc gcttctgctg acgaatggcc gactctgcat     300

gtgtttggcg gcggcacgaa gttaaccgtt cttggccag                            339


<210> 140
<211> 375
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..375
<223> /mol_type="unassigned DNA"
      /note="VH (DNA)"
      /organism="Artificial Sequence"

<400> 140
gaagtgcaat tggtgcagag cggtgcggaa gtgaaaaaac cgggcgaaag cctgaaaatt      60

agctgcaaag gctccggata tagcttcact gactactgga tctcttgggt gcgccagatg     120

ccgggcaaag gtctcgagtg gatgggcgct atcgacccga ctgacagcta cacccgttat     180

agcccgagct ttcagggcca ggtgaccatt agcgcggata aaagcatcag caccgcgtat     240

ctgcaatgga gcagcctgaa agcgagcgat accgcgatgt attattgcgc gcgttggtac     300

acttctcatc cgtactacga aggtcgttac ccgatggatg tttggggcca aggcaccctg     360

gtgactgtta gctca                                                      375


<210> 141
<211> 10
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR1

<400> 141
Gly Tyr Ser Phe Asn Asn Tyr Trp Ile Ala 
1               5                   10  

<210> 142
<211> 20
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR2

<400> 142
Trp Met Gly Phe Ile Tyr Pro Ser Asn Ser Ala Thr Gln Tyr Ser Pro 
1               5                   10                  15      
Ser Phe Gln Gly 
            20  

<210> 143
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR3

<400> 143
Asp Asn Glu Tyr Ser Asp Ser Tyr Phe Asp Val 
1               5                   10      

<210> 144
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR1

<400> 144
Arg Ala Ser Gln Ile Val Ser Ser Tyr Leu Ala 
1               5                   10      

<210> 145
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR2

<400> 145
Leu Leu Ile Tyr Asp Ala Ser Ser Arg Ala Thr 
1               5                   10      

<210> 146
<211> 8
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR3

<400> 146
Gln Gln Ser Val Asn Phe Pro Thr 
1               5               

<210> 147
<211> 109
<212> PRT
<213> synthetic construct

<220> 
<223> VL

<400> 147
Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ile Val Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Val Asn Phe Pro Thr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 

<210> 148
<211> 120
<212> PRT
<213> synthetic construct

<220> 
<223> VH

<400> 148
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Asn Asn Tyr 
            20                  25                  30          
Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Phe Ile Tyr Pro Ser Asn Ser Ala Thr Gln Tyr Ser Pro Ser Phe 
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Asn Glu Tyr Ser Asp Ser Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 

<210> 149
<211> 327
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..327
<223> /mol_type="unassigned DNA"
      /note="VL (DNA)"
      /organism="Artificial Sequence"

<400> 149
gatatcgtgc tgacccagag cccggcgacc ctgagcctga gcccgggtga acgtgccacc      60

ctgagctgca gagcgagcca gatcgtttct tcttacctgg cttggtacca gcagaaaccg     120

ggccaggccc cgcgtctatt aatctacgac gcttcttctc gtgcgaccgg cattccggcg     180

cgttttagcg gcagcggatc cggcaccgat ttcaccctga ccattagcag cctggaaccg     240

gaagactttg cggtgtatta ttgccagcag tctgttaact tcccgactac ctttggccag     300

ggcacgaaag ttgaaattaa acgtacg                                         327


<210> 150
<211> 360
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..360
<223> /mol_type="unassigned DNA"
      /note="VH (DNA)"
      /organism="Artificial Sequence"

<400> 150
gaagtgcaat tggtgcagag cggtgcggaa gtgaaaaaac cgggcgaaag cctgaaaatt      60

agctgcaaag gctccggata tagcttcaac aactactgga tcgcttgggt gcgccagatg     120

ccgggcaaag gtctcgagtg gatgggcttc atctacccgt ctaacagcgc tacccagtat     180

agcccgagct ttcagggcca ggtgaccatt agcgcggata aaagcatcag caccgcgtat     240

ctgcaatgga gcagcctgaa agcgagcgat accgcgatgt attattgcgc gcgtgacaac     300

gaatactctg actcttactt cgatgtttgg ggccaaggca ccctggtgac tgttagctca     360


<210> 151
<211> 10
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR1

<400> 151
Gly Tyr Ser Phe Asn Asn Tyr Trp Ile Ala 
1               5                   10  

<210> 152
<211> 20
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR2

<400> 152
Trp Met Gly Phe Ile Tyr Pro Ser Asn Ser Ala Thr Gln Tyr Ser Pro 
1               5                   10                  15      
Ser Phe Gln Gly 
            20  

<210> 153
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR3

<400> 153
Asp Asn Glu Tyr Ser Asp Ser Tyr Phe Asp Val 
1               5                   10      

<210> 154
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR1

<400> 154
Arg Ala Ser Gln Ile Val Ser Ser Tyr Leu Ala 
1               5                   10      

<210> 155
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR2

<400> 155
Leu Leu Ile Tyr Asp Ala Ser Ser Arg Ala Thr 
1               5                   10      

<210> 156
<211> 7
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR3

<400> 156
Gln Gln Ser Val Lys Ser Asn 
1               5           

<210> 157
<211> 108
<212> PRT
<213> synthetic construct

<220> 
<223> VL

<400> 157
Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ile Val Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Val Lys Ser Asn Thr 
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105             

<210> 158
<211> 120
<212> PRT
<213> synthetic construct

<220> 
<223> VH

<400> 158
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Asn Asn Tyr 
            20                  25                  30          
Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Phe Ile Tyr Pro Ser Asn Ser Ala Thr Gln Tyr Ser Pro Ser Phe 
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Asn Glu Tyr Ser Asp Ser Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 

<210> 159
<211> 324
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..324
<223> /mol_type="unassigned DNA"
      /note="VL (DNA)"
      /organism="Artificial Sequence"

<400> 159
gatatcgtgc tgacccagag cccggcgacc ctgagcctga gcccgggtga acgtgccacc      60

ctgagctgca gagcgagcca gatcgtttct tcttacctgg cttggtacca gcagaaaccg     120

ggccaggccc cgcgtctatt aatctacgac gcttcttctc gtgcgaccgg cattccggcg     180

cgttttagcg gcagcggatc cggcaccgat ttcaccctga ccattagcag cctggaaccg     240

gaagactttg cgacctatta ttgccagcag tctgttaaat ctaacacctt tggccagggc     300

acgaaagttg aaattaaacg tacg                                            324


<210> 160
<211> 360
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..360
<223> /mol_type="unassigned DNA"
      /note="VH (DNA)"
      /organism="Artificial Sequence"

<400> 160
gaagtgcaat tggtgcagag cggtgcggaa gtgaaaaaac cgggcgaaag cctgaaaatt      60

agctgcaaag gctccggata tagcttcaac aactactgga tcgcttgggt gcgccagatg     120

ccgggcaaag gtctcgagtg gatgggcttc atctacccgt ctaacagcgc tacccagtat     180

agcccgagct ttcagggcca ggtgaccatt agcgcggata aaagcatcag caccgcgtat     240

ctgcaatgga gcagcctgaa agcgagcgat accgcgatgt attattgcgc gcgtgacaac     300

gaatactctg actcttactt cgatgtttgg ggccaaggca ccctggtgac tgttagctca     360


<210> 161
<211> 10
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR1

<400> 161
Gly Tyr Ser Phe Asn Asn Tyr Trp Ile Ala 
1               5                   10  

<210> 162
<211> 20
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR2

<400> 162
Trp Met Gly Phe Ile Tyr Pro Ser Asn Ser Ala Thr Gln Tyr Ser Pro 
1               5                   10                  15      
Ser Phe Gln Gly 
            20  

<210> 163
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR3

<400> 163
Asp Asn Glu Tyr Ser Asp Ser Tyr Phe Asp Val 
1               5                   10      

<210> 164
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR1

<400> 164
Arg Ala Ser Gln Ile Val Ser Ser Tyr Leu Ala 
1               5                   10      

<210> 165
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR2

<400> 165
Leu Leu Ile Tyr Asp Ala Ser Ser Arg Ala Thr 
1               5                   10      

<210> 166
<211> 8
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR3

<400> 166
Gln Gln Ser Asn Gly Trp Leu Pro 
1               5               

<210> 167
<211> 109
<212> PRT
<213> synthetic construct

<220> 
<223> VL

<400> 167
Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ile Val Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Gly Trp Leu Pro 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 

<210> 168
<211> 120
<212> PRT
<213> synthetic construct

<220> 
<223> VH

<400> 168
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Asn Asn Tyr 
            20                  25                  30          
Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Phe Ile Tyr Pro Ser Asn Ser Ala Thr Gln Tyr Ser Pro Ser Phe 
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Asn Glu Tyr Ser Asp Ser Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 

<210> 169
<211> 327
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..327
<223> /mol_type="unassigned DNA"
      /note="VL (DNA)"
      /organism="Artificial Sequence"

<400> 169
gatatcgtgc tgacccagag cccggcgacc ctgagcctga gcccgggtga acgtgccacc      60

ctgagctgca gagcgagcca gatcgtttct tcttacctgg cttggtacca gcagaaaccg     120

ggccaggccc cgcgtctatt aatctacgac gcttcttctc gtgcgaccgg cattccggcg     180

cgttttagcg gcagcggatc cggcaccgat ttcaccctga ccattagcag cctggaaccg     240

gaagactttg cgacctatta ttgccagcag tctaacggtt ggctgccgac ctttggccag     300

ggcacgaaag ttgaaattaa acgtacg                                         327


<210> 170
<211> 360
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..360
<223> /mol_type="unassigned DNA"
      /note="VH (DNA)"
      /organism="Artificial Sequence"

<400> 170
gaagtgcaat tggtgcagag cggtgcggaa gtgaaaaaac cgggcgaaag cctgaaaatt      60

agctgcaaag gctccggata tagcttcaac aactactgga tcgcttgggt gcgccagatg     120

ccgggcaaag gtctcgagtg gatgggtttc atctacccgt ctaacagcgc tacccagtat     180

agcccgagct ttcagggcca ggtgaccatt agcgcggata aaagcatcag caccgcgtat     240

ctgcaatgga gcagcctgaa agcgagcgat accgcgatgt attattgcgc gcgtgacaac     300

gaatactctg actcttactt cgatgtttgg ggccaaggca ccctggtgac tgttagctca     360


<210> 171
<211> 10
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR1

<400> 171
Gly Tyr Ser Phe Asn Asn Tyr Trp Ile Ala 
1               5                   10  

<210> 172
<211> 20
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR2

<400> 172
Trp Met Gly Phe Ile Tyr Pro Ser Asn Ser Ala Thr Gln Tyr Ser Pro 
1               5                   10                  15      
Ser Phe Gln Gly 
            20  

<210> 173
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR3

<400> 173
Asp Asn Glu Tyr Ser Asp Ser Tyr Phe Asp Val 
1               5                   10      

<210> 174
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR1

<400> 174
Arg Ala Ser Gln Ile Val Ser Ser Tyr Leu Ala 
1               5                   10      

<210> 175
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR2

<400> 175
Leu Leu Ile Tyr Asp Ala Ser Ser Arg Ala Thr 
1               5                   10      

<210> 176
<211> 8
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR3

<400> 176
Gln Gln Ser Glu Gln Val Pro Thr 
1               5               

<210> 177
<211> 109
<212> PRT
<213> synthetic construct

<220> 
<223> VL

<400> 177
Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ile Val Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Glu Gln Val Pro Thr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 

<210> 178
<211> 120
<212> PRT
<213> synthetic construct

<220> 
<223> VH

<400> 178
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Asn Asn Tyr 
            20                  25                  30          
Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Phe Ile Tyr Pro Ser Asn Ser Ala Thr Gln Tyr Ser Pro Ser Phe 
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Asn Glu Tyr Ser Asp Ser Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 

<210> 179
<211> 327
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..327
<223> /mol_type="unassigned DNA"
      /note="VL (DNA)"
      /organism="Artificial Sequence"

<400> 179
gatatcgtgc tgacccagag cccggcgacc ctgagcctga gcccgggtga acgtgccacc      60

ctgagctgca gagcgagcca gatcgtttct tcttacctgg cttggtacca gcagaaaccg     120

ggccaggccc cgcgtctatt aatctacgac gcttcttctc gtgcgaccgg cattccggcg     180

cgttttagcg gcagcggatc cggcaccgat ttcaccctga ccattagcag cctggaaccg     240

gaagactttg cggtgtatta ttgccagcag tctgaacagg ttccgactac ctttggccag     300

ggcacgaaag ttgaaattaa acgtacg                                         327


<210> 180
<211> 360
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..360
<223> /mol_type="unassigned DNA"
      /note="VH (DNA)"
      /organism="Artificial Sequence"

<400> 180
gaagtgcaat tggtgcagag cggtgcggaa gtgaaaaaac cgggcgaaag cctgaaaatt      60

agctgcaaag gctccggata tagcttcaac aactactgga tcgcttgggt gcgccagatg     120

ccgggcaaag gtctcgagtg gatgggcttc atctacccgt ctaacagcgc tacccagtat     180

agcccgagct ttcagggcca ggtgaccatt agcgcggata aaagcatcag caccgcgtat     240

ctgcaatgga gcagcctgaa agcgagcgat accgcgatgt attattgcgc gcgtgacaac     300

gaatactctg actcttactt cgatgtttgg ggccaaggca ccctggtgac tgttagctca     360


<210> 181
<211> 197
<212> PRT
<213> Homo sapiens

<220> 
<223> IL17C

<400> 181
Met Thr Leu Leu Pro Gly Leu Leu Phe Leu Thr Trp Leu His Thr Cys 
1               5                   10                  15      
Leu Ala His His Asp Pro Ser Leu Arg Gly His Pro His Ser His Gly 
            20                  25                  30          
Thr Pro His Cys Tyr Ser Ala Glu Glu Leu Pro Leu Gly Gln Ala Pro 
        35                  40                  45              
Pro His Leu Leu Ala Arg Gly Ala Lys Trp Gly Gln Ala Leu Pro Val 
    50                  55                  60                  
Ala Leu Val Ser Ser Leu Glu Ala Ala Ser His Arg Gly Arg His Glu 
65                  70                  75                  80  
Arg Pro Ser Ala Thr Thr Gln Cys Pro Val Leu Arg Pro Glu Glu Val 
                85                  90                  95      
Leu Glu Ala Asp Thr His Gln Arg Ser Ile Ser Pro Trp Arg Tyr Arg 
            100                 105                 110         
Val Asp Thr Asp Glu Asp Arg Tyr Pro Gln Lys Leu Ala Phe Ala Glu 
        115                 120                 125             
Cys Leu Cys Arg Gly Cys Ile Asp Ala Arg Thr Gly Arg Glu Thr Ala 
    130                 135                 140                 
Ala Leu Asn Ser Val Arg Leu Leu Gln Ser Leu Leu Val Leu Arg Arg 
145                 150                 155                 160 
Arg Pro Cys Ser Arg Asp Gly Ser Gly Leu Pro Thr Pro Gly Ala Phe 
                165                 170                 175     
Ala Phe His Thr Glu Phe Ile His Val Pro Val Gly Cys Thr Cys Val 
            180                 185                 190         
Leu Pro Arg Ser Val 
        195         

<210> 182
<211> 866
<212> PRT
<213> Homo sapiens

<220> 
<223> IL17RA

<400> 182
Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu 
1               5                   10                  15      
Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser 
            20                  25                  30          
Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu 
        35                  40                  45              
Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His 
    50                  55                  60                  
Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu 
65                  70                  75                  80  
His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile 
                85                  90                  95      
Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala 
            100                 105                 110         
Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg 
        115                 120                 125             
Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg Phe 
    130                 135                 140                 
Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val Thr 
145                 150                 155                 160 
Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln 
                165                 170                 175     
Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys Val 
            180                 185                 190         
Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr 
        195                 200                 205             
Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp 
    210                 215                 220                 
Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met 
225                 230                 235                 240 
Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg 
                245                 250                 255     
Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn 
            260                 265                 270         
Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser 
        275                 280                 285             
Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys Pro 
    290                 295                 300                 
Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr Met Pro Leu Trp 
305                 310                 315                 320 
Val Tyr Trp Phe Ile Thr Gly Ile Ser Ile Leu Leu Val Gly Ser Val 
                325                 330                 335     
Ile Leu Leu Ile Val Cys Met Thr Trp Arg Leu Ala Gly Pro Gly Ser 
            340                 345                 350         
Glu Lys Tyr Ser Asp Asp Thr Lys Tyr Thr Asp Gly Leu Pro Ala Ala 
        355                 360                 365             
Asp Leu Ile Pro Pro Pro Leu Lys Pro Arg Lys Val Trp Ile Ile Tyr 
    370                 375                 380                 
Ser Ala Asp His Pro Leu Tyr Val Asp Val Val Leu Lys Phe Ala Gln 
385                 390                 395                 400 
Phe Leu Leu Thr Ala Cys Gly Thr Glu Val Ala Leu Asp Leu Leu Glu 
                405                 410                 415     
Glu Gln Ala Ile Ser Glu Ala Gly Val Met Thr Trp Val Gly Arg Gln 
            420                 425                 430         
Lys Gln Glu Met Val Glu Ser Asn Ser Lys Ile Ile Val Leu Cys Ser 
        435                 440                 445             
Arg Gly Thr Arg Ala Lys Trp Gln Ala Leu Leu Gly Arg Gly Ala Pro 
    450                 455                 460                 
Val Arg Leu Arg Cys Asp His Gly Lys Pro Val Gly Asp Leu Phe Thr 
465                 470                 475                 480 
Ala Ala Met Asn Met Ile Leu Pro Asp Phe Lys Arg Pro Ala Cys Phe 
                485                 490                 495     
Gly Thr Tyr Val Val Cys Tyr Phe Ser Glu Val Ser Cys Asp Gly Asp 
            500                 505                 510         
Val Pro Asp Leu Phe Gly Ala Ala Pro Arg Tyr Pro Leu Met Asp Arg 
        515                 520                 525             
Phe Glu Glu Val Tyr Phe Arg Ile Gln Asp Leu Glu Met Phe Gln Pro 
    530                 535                 540                 
Gly Arg Met His Arg Val Gly Glu Leu Ser Gly Asp Asn Tyr Leu Arg 
545                 550                 555                 560 
Ser Pro Gly Gly Arg Gln Leu Arg Ala Ala Leu Asp Arg Phe Arg Asp 
                565                 570                 575     
Trp Gln Val Arg Cys Pro Asp Trp Phe Glu Cys Glu Asn Leu Tyr Ser 
            580                 585                 590         
Ala Asp Asp Gln Asp Ala Pro Ser Leu Asp Glu Glu Val Phe Glu Glu 
        595                 600                 605             
Pro Leu Leu Pro Pro Gly Thr Gly Ile Val Lys Arg Ala Pro Leu Val 
    610                 615                 620                 
Arg Glu Pro Gly Ser Gln Ala Cys Leu Ala Ile Asp Pro Leu Val Gly 
625                 630                 635                 640 
Glu Glu Gly Gly Ala Ala Val Ala Lys Leu Glu Pro His Leu Gln Pro 
                645                 650                 655     
Arg Gly Gln Pro Ala Pro Gln Pro Leu His Thr Leu Val Leu Ala Ala 
            660                 665                 670         
Glu Glu Gly Ala Leu Val Ala Ala Val Glu Pro Gly Pro Leu Ala Asp 
        675                 680                 685             
Gly Ala Ala Val Arg Leu Ala Leu Ala Gly Glu Gly Glu Ala Cys Pro 
    690                 695                 700                 
Leu Leu Gly Ser Pro Gly Ala Gly Arg Asn Ser Val Leu Phe Leu Pro 
705                 710                 715                 720 
Val Asp Pro Glu Asp Ser Pro Leu Gly Ser Ser Thr Pro Met Ala Ser 
                725                 730                 735     
Pro Asp Leu Leu Pro Glu Asp Val Arg Glu His Leu Glu Gly Leu Met 
            740                 745                 750         
Leu Ser Leu Phe Glu Gln Ser Leu Ser Cys Gln Ala Gln Gly Gly Cys 
        755                 760                 765             
Ser Arg Pro Ala Met Val Leu Thr Asp Pro His Thr Pro Tyr Glu Glu 
    770                 775                 780                 
Glu Gln Arg Gln Ser Val Gln Ser Asp Gln Gly Tyr Ile Ser Arg Ser 
785                 790                 795                 800 
Ser Pro Gln Pro Pro Glu Gly Leu Thr Glu Met Glu Glu Glu Glu Glu 
                805                 810                 815     
Glu Glu Gln Asp Pro Gly Lys Pro Ala Leu Pro Leu Ser Pro Glu Asp 
            820                 825                 830         
Leu Glu Ser Leu Arg Ser Leu Gln Arg Gln Leu Leu Phe Arg Gln Leu 
        835                 840                 845             
Gln Lys Asn Ser Gly Trp Asp Thr Met Gly Ser Glu Ser Glu Gly Pro 
    850                 855                 860                 
Ser Ala 
865     

<210> 183
<211> 667
<212> PRT
<213> Homo sapiens

<220> 
<223> IL17RE

<400> 183
Met Gly Ser Ser Arg Leu Ala Ala Leu Leu Leu Pro Leu Leu Leu Ile 
1               5                   10                  15      
Val Ile Asp Leu Ser Asp Ser Ala Gly Ile Gly Phe Arg His Leu Pro 
            20                  25                  30          
His Trp Asn Thr Arg Cys Pro Leu Ala Ser His Thr Asp Asp Ser Phe 
        35                  40                  45              
Thr Gly Ser Ser Ala Tyr Ile Pro Cys Arg Thr Trp Trp Ala Leu Phe 
    50                  55                  60                  
Ser Thr Lys Pro Trp Cys Val Arg Val Trp His Cys Ser Arg Cys Leu 
65                  70                  75                  80  
Cys Gln His Leu Leu Ser Gly Gly Ser Gly Leu Gln Arg Gly Leu Phe 
                85                  90                  95      
His Leu Leu Val Gln Lys Ser Lys Lys Ser Ser Thr Phe Lys Phe Tyr 
            100                 105                 110         
Arg Arg His Lys Met Pro Ala Pro Ala Gln Arg Lys Leu Leu Pro Arg 
        115                 120                 125             
Arg His Leu Ser Glu Lys Ser His His Ile Ser Ile Pro Ser Pro Asp 
    130                 135                 140                 
Ile Ser His Lys Gly Leu Arg Ser Lys Arg Thr Gln Pro Ser Asp Pro 
145                 150                 155                 160 
Glu Thr Trp Glu Ser Leu Pro Arg Leu Asp Ser Gln Arg His Gly Gly 
                165                 170                 175     
Pro Glu Phe Ser Phe Asp Leu Leu Pro Glu Ala Arg Ala Ile Arg Val 
            180                 185                 190         
Thr Ile Ser Ser Gly Pro Glu Val Ser Val Arg Leu Cys His Gln Trp 
        195                 200                 205             
Ala Leu Glu Cys Glu Glu Leu Ser Ser Pro Tyr Asp Val Gln Lys Ile 
    210                 215                 220                 
Val Ser Gly Gly His Thr Val Glu Leu Pro Tyr Glu Phe Leu Leu Pro 
225                 230                 235                 240 
Cys Leu Cys Ile Glu Ala Ser Tyr Leu Gln Glu Asp Thr Val Arg Arg 
                245                 250                 255     
Lys Lys Cys Pro Phe Gln Ser Trp Pro Glu Ala Tyr Gly Ser Asp Phe 
            260                 265                 270         
Trp Lys Ser Val His Phe Thr Asp Tyr Ser Gln His Thr Gln Met Val 
        275                 280                 285             
Met Ala Leu Thr Leu Arg Cys Pro Leu Lys Leu Glu Ala Ala Leu Cys 
    290                 295                 300                 
Gln Arg His Asp Trp His Thr Leu Cys Lys Asp Leu Pro Asn Ala Thr 
305                 310                 315                 320 
Ala Arg Glu Ser Asp Gly Trp Tyr Val Leu Glu Lys Val Asp Leu His 
                325                 330                 335     
Pro Gln Leu Cys Phe Lys Phe Ser Phe Gly Asn Ser Ser His Val Glu 
            340                 345                 350         
Cys Pro His Gln Thr Gly Ser Leu Thr Ser Trp Asn Val Ser Met Asp 
        355                 360                 365             
Thr Gln Ala Gln Gln Leu Ile Leu His Phe Ser Ser Arg Met His Ala 
    370                 375                 380                 
Thr Phe Ser Ala Ala Trp Ser Leu Pro Gly Leu Gly Gln Asp Thr Leu 
385                 390                 395                 400 
Val Pro Pro Val Tyr Thr Val Ser Gln Ala Arg Gly Ser Ser Pro Val 
                405                 410                 415     
Ser Leu Asp Leu Ile Ile Pro Phe Leu Arg Pro Gly Cys Cys Val Leu 
            420                 425                 430         
Val Trp Arg Ser Asp Val Gln Phe Ala Trp Lys His Leu Leu Cys Pro 
        435                 440                 445             
Asp Val Ser Tyr Arg His Leu Gly Leu Leu Ile Leu Ala Leu Leu Ala 
    450                 455                 460                 
Leu Leu Thr Leu Leu Gly Val Val Leu Ala Leu Thr Cys Arg Arg Pro 
465                 470                 475                 480 
Gln Ser Gly Pro Gly Pro Ala Arg Pro Val Leu Leu Leu His Ala Ala 
                485                 490                 495     
Asp Ser Glu Ala Gln Arg Arg Leu Val Gly Ala Leu Ala Glu Leu Leu 
            500                 505                 510         
Arg Ala Ala Leu Gly Gly Gly Arg Asp Val Ile Val Asp Leu Trp Glu 
        515                 520                 525             
Gly Arg His Val Ala Arg Val Gly Pro Leu Pro Trp Leu Trp Ala Ala 
    530                 535                 540                 
Arg Thr Arg Val Ala Arg Glu Gln Gly Thr Val Leu Leu Leu Trp Ser 
545                 550                 555                 560 
Gly Ala Asp Leu Arg Pro Val Ser Gly Pro Asp Pro Arg Ala Ala Pro 
                565                 570                 575     
Leu Leu Ala Leu Leu His Ala Ala Pro Arg Pro Leu Leu Leu Leu Ala 
            580                 585                 590         
Tyr Phe Ser Arg Leu Cys Ala Lys Gly Asp Ile Pro Pro Pro Leu Arg 
        595                 600                 605             
Ala Leu Pro Arg Tyr Arg Leu Leu Arg Asp Leu Pro Arg Leu Leu Arg 
    610                 615                 620                 
Ala Leu Asp Ala Arg Pro Phe Ala Glu Ala Thr Ser Trp Gly Arg Leu 
625                 630                 635                 640 
Gly Ala Arg Gln Arg Arg Gln Ser Arg Leu Glu Leu Cys Ser Arg Leu 
                645                 650                 655     
Glu Arg Glu Ala Ala Arg Leu Ala Asp Leu Gly 
            660                 665         

<210> 184
<211> 21
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned DNA"
      /note="F-Primer"
      /organism="synthetic construct"

<400> 184
atgaggaccg ctatccacag a                                              21


<210> 185
<211> 16
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..16
<223> /mol_type="unassigned DNA"
      /note="R-Primer"
      /organism="synthetic construct"

<400> 185
cccgtccgtg catcga                                                    16


<210> 186
<211> 20
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Probe"
      /organism="synthetic construct"

<400> 186
tggccttcgc cgagtgcctg                                                20


