                         SEQUENCE LISTING

<110>  CSL Behring GmbH
 
<120>  Combined use of a sulfated glycosaminoglycan and a hyaluronidase 
       for improving the bioavailability of blood coagulation factors

<130>  A185

<150>  EP 11185650.6
<151>  2011-10-18

<150>  US 61/548612
<151>  2011-10-18

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  6996
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (1)..(6996)

<400>  1
gcc acc aga aga tac tac ctg ggt gca gtg gaa ctg tca tgg gac tat         48
Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr           
1               5                   10                  15                

atg caa agt gat ctc ggt gag ctg cct gtg gac gca aga ttt cct cct         96
Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro           
            20                  25                  30                    

aga gtg cca aaa tct ttt cca ttc aac acc tca gtc gtg tac aaa aag        144
Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys           
        35                  40                  45                        

act ctg ttt gta gaa ttc acg gat cac ctt ttc aac atc gct aag cca        192
Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro           
    50                  55                  60                            

agg cca ccc tgg atg ggt ctg cta ggt cct acc atc cag gct gag gtt        240
Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val           
65                  70                  75                  80            

tat gat aca gtg gtc att aca ctt aag aac atg gct tcc cat cct gtc        288
Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val           
                85                  90                  95                

agt ctt cat gct gtt ggt gta tcc tac tgg aaa gct tct gag gga gct        336
Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala           
            100                 105                 110                   

gaa tat gat gat cag acc agt caa agg gag aaa gaa gat gat aaa gtc        384
Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val           
        115                 120                 125                       

ttc cct ggt gga agc cat aca tat gtc tgg cag gtc ctg aaa gag aat        432
Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn           
    130                 135                 140                           

ggt cca atg gcc tct gac cca ctg tgc ctt acc tac tca tat ctt tct        480
Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser           
145                 150                 155                 160           

cat gtg gac ctg gta aaa gac ttg aat tca ggc ctc att gga gcc cta        528
His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu           
                165                 170                 175               

cta gta tgt aga gaa ggg agt ctg gcc aag gaa aag aca cag acc ttg        576
Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu           
            180                 185                 190                   

cac aaa ttt ata cta ctt ttt gct gta ttt gat gaa ggg aaa agt tgg        624
His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp           
        195                 200                 205                       

cac tca gaa aca aag aac tcc ttg atg cag gat agg gat gct gca tct        672
His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser           
    210                 215                 220                           

gct cgg gcc tgg cct aaa atg cac aca gtc aat ggt tat gta aac agg        720
Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg           
225                 230                 235                 240           

tct ctg cca ggt ctg att gga tgc cac agg aaa tca gtc tat tgg cat        768
Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His           
                245                 250                 255               

gtg att gga atg ggc acc act cct gaa gtg cac tca ata ttc ctc gaa        816
Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu           
            260                 265                 270                   

ggt cac aca ttt ctt gtg agg aac cat cgc cag gcg tcc ttg gaa atc        864
Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile           
        275                 280                 285                       

tcg cca ata act ttc ctt act gct caa aca ctc ttg atg gac ctt gga        912
Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly           
    290                 295                 300                           

cag ttt cta ctg ttt tgt cat atc tct tcc cac caa cat gat ggc atg        960
Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met           
305                 310                 315                 320           

gaa gct tat gtc aaa gta gac agc tgt cca gag gaa ccc caa cta cga       1008
Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg           
                325                 330                 335               

atg aaa aat aat gaa gaa gcg gaa gac tat gat gat gat ctt act gat       1056
Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp           
            340                 345                 350                   

tct gaa atg gat gtg gtc agg ttt gat gat gac aac tct cct tcc ttt       1104
Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe           
        355                 360                 365                       

atc caa att cgc tca gtt gcc aag aag cat cct aaa act tgg gta cat       1152
Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His           
    370                 375                 380                           

tac att gct gct gaa gag gag gac tgg gac tat gct ccc tta gtc ctc       1200
Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu           
385                 390                 395                 400           

gcc ccc gat gac aga agt tat aaa agt caa tat ttg aac aat ggc cct       1248
Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro           
                405                 410                 415               

cag cgg att ggt agg aag tac aaa aaa gtc cga ttt atg gca tac aca       1296
Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr           
            420                 425                 430                   

gat gaa acc ttt aag act cgt gaa gct att cag cat gaa tca gga atc       1344
Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile           
        435                 440                 445                       

ttg gga cct tta ctt tat ggg gaa gtt gga gac aca ctg ttg att ata       1392
Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile           
    450                 455                 460                           

ttt aag aat caa gca agc aga cca tat aac atc tac cct cac gga atc       1440
Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile           
465                 470                 475                 480           

act gat gtc cgt cct ttg tat tca agg aga tta cca aaa ggt gta aaa       1488
Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys           
                485                 490                 495               

cat ttg aag gat ttt cca att ctg cca gga gaa ata ttc aaa tat aaa       1536
His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys           
            500                 505                 510                   

tgg aca gtg act gta gaa gat ggg cca act aaa tca gat cct cgg tgc       1584
Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys           
        515                 520                 525                       

ctg acc cgc tat tac tct agt ttc gtt aat atg gag aga gat cta gct       1632
Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala           
    530                 535                 540                           

tca gga ctc att ggc cct ctc ctc atc tgc tac aaa gaa tct gta gat       1680
Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp           
545                 550                 555                 560           

caa aga gga aac cag ata atg tca gac aag agg aat gtc atc ctg ttt       1728
Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe           
                565                 570                 575               

tct gta ttt gat gag aac cga agc tgg tac ctc aca gag aat ata caa       1776
Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln           
            580                 585                 590                   

cgc ttt ctc ccc aat cca gct gga gtg cag ctt gag gat cca gag ttc       1824
Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe           
        595                 600                 605                       

caa gcc tcc aac atc atg cac agc atc aat ggc tat gtt ttt gat agt       1872
Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser           
    610                 615                 620                           

ttg cag ttg tca gtt tgt ttg cat gag gtg gca tac tgg tac att cta       1920
Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu           
625                 630                 635                 640           

agc att gga gca cag act gac ttc ctt tct gtc ttc ttc tct gga tat       1968
Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr           
                645                 650                 655               

acc ttc aaa cac aaa atg gtc tat gaa gac aca ctc acc cta ttc cca       2016
Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro           
            660                 665                 670                   

ttc tca gga gaa act gtc ttc atg tcg atg gaa aac cca ggt cta tgg       2064
Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp           
        675                 680                 685                       

att ctg ggg tgc cac aac tca gac ttt cgg aac aga ggc atg acc gcc       2112
Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala           
    690                 695                 700                           

tta ctg aag gtt tct agt tgt gac aag aac act ggt gat tat tac gag       2160
Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu           
705                 710                 715                 720           

gac agt tat gaa gat att tca gca tac ttg ctg agt aaa aac aat gcc       2208
Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala           
                725                 730                 735               

att gaa cca aga agc ttc tcc cag aat tca aga cac cgt agc act agg       2256
Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Arg Ser Thr Arg           
            740                 745                 750                   

caa aag caa ttt aat gcc acc aca att cca gaa aat gac ata gag aag       2304
Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys           
        755                 760                 765                       

act gac cct tgg ttt gca cac aga aca cct atg cct aaa ata caa aat       2352
Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn           
    770                 775                 780                           

gtc tcc tct agt gat ttg ttg atg ctc ttg cga cag agt cct act cca       2400
Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro           
785                 790                 795                 800           

cat ggg cta tcc tta tct gat ctc caa gaa gcc aaa tat gag act ttt       2448
His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe           
                805                 810                 815               

tct gat gat cca tca cct gga gca ata gac agt aat aac agc ctg tct       2496
Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser           
            820                 825                 830                   

gaa atg aca cac ttc agg cca cag ctc cat cac agt ggg gac atg gta       2544
Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val           
        835                 840                 845                       

ttt acc cct gag tca ggc ctc caa tta aga tta aat gag aaa ctg ggg       2592
Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly           
    850                 855                 860                           

aca act gca gca aca gag ttg aag aaa ctt gat ttc aaa gtt tct agt       2640
Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser           
865                 870                 875                 880           

aca tca aat aat ctg att tca aca att cca tca gac aat ttg gca gca       2688
Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala           
                885                 890                 895               

ggt act gat aat aca agt tcc tta gga ccc cca agt atg cca gtt cat       2736
Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His           
            900                 905                 910                   

tat gat agt caa tta gat acc act cta ttt ggc aaa aag tca tct ccc       2784
Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro           
        915                 920                 925                       

ctt act gag tct ggt gga cct ctg agc ttg agt gaa gaa aat aat gat       2832
Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp           
    930                 935                 940                           

tca aag ttg tta gaa tca ggt tta atg aat agc caa gaa agt tca tgg       2880
Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp           
945                 950                 955                 960           

gga aaa aat gta tcg tca aca gag agt ggt agg tta ttt aaa ggg aaa       2928
Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys           
                965                 970                 975               

aga gct cat gga cct gct ttg ttg act aaa gat aat gcc tta ttc aaa       2976
Arg Ala His Gly Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys           
            980                 985                 990                   

gtt agc atc tct ttg tta aag aca  aac aaa act tcc aat  aat tca gca     3024
Val Ser Ile Ser Leu Leu Lys Thr  Asn Lys Thr Ser Asn  Asn Ser Ala         
        995                 1000                 1005                     

act aat  aga aag act cac att  gat ggc cca tca tta  tta att gag        3069
Thr Asn  Arg Lys Thr His Ile  Asp Gly Pro Ser Leu  Leu Ile Glu            
    1010                 1015                 1020                        

aat agt  cca tca gtc tgg caa  aat ata tta gaa agt  gac act gag        3114
Asn Ser  Pro Ser Val Trp Gln  Asn Ile Leu Glu Ser  Asp Thr Glu            
    1025                 1030                 1035                        

ttt aaa  aaa gtg aca cct ttg  att cat gac aga atg  ctt atg gac        3159
Phe Lys  Lys Val Thr Pro Leu  Ile His Asp Arg Met  Leu Met Asp            
    1040                 1045                 1050                        

aaa aat  gct aca gct ttg agg  cta aat cat atg tca  aat aaa act        3204
Lys Asn  Ala Thr Ala Leu Arg  Leu Asn His Met Ser  Asn Lys Thr            
    1055                 1060                 1065                        

act tca  tca aaa aac atg gaa  atg gtc caa cag aaa  aaa gag ggc        3249
Thr Ser  Ser Lys Asn Met Glu  Met Val Gln Gln Lys  Lys Glu Gly            
    1070                 1075                 1080                        

ccc att  cca cca gat gca caa  aat cca gat atg tcg  ttc ttt aag        3294
Pro Ile  Pro Pro Asp Ala Gln  Asn Pro Asp Met Ser  Phe Phe Lys            
    1085                 1090                 1095                        

atg cta  ttc ttg cca gaa tca  gca agg tgg ata caa  agg act cat        3339
Met Leu  Phe Leu Pro Glu Ser  Ala Arg Trp Ile Gln  Arg Thr His            
    1100                 1105                 1110                        

gga aag  aac tct ctg aac tct  ggg caa ggc ccc agt  cca aag caa        3384
Gly Lys  Asn Ser Leu Asn Ser  Gly Gln Gly Pro Ser  Pro Lys Gln            
    1115                 1120                 1125                        

tta gta  tcc tta gga cca gaa  aaa tct gtg gaa ggt  cag aat ttc        3429
Leu Val  Ser Leu Gly Pro Glu  Lys Ser Val Glu Gly  Gln Asn Phe            
    1130                 1135                 1140                        

ttg tct  gag aaa aac aaa gtg  gta gta gga aag ggt  gaa ttt aca        3474
Leu Ser  Glu Lys Asn Lys Val  Val Val Gly Lys Gly  Glu Phe Thr            
    1145                 1150                 1155                        

aag gac  gta gga ctc aaa gag  atg gtt ttt cca agc  agc aga aac        3519
Lys Asp  Val Gly Leu Lys Glu  Met Val Phe Pro Ser  Ser Arg Asn            
    1160                 1165                 1170                        

cta ttt  ctt act aac ttg gat  aat tta cat gaa aat  aat aca cac        3564
Leu Phe  Leu Thr Asn Leu Asp  Asn Leu His Glu Asn  Asn Thr His            
    1175                 1180                 1185                        

aat caa  gaa aaa aaa att cag  gaa gaa ata gaa aag  aag gaa aca        3609
Asn Gln  Glu Lys Lys Ile Gln  Glu Glu Ile Glu Lys  Lys Glu Thr            
    1190                 1195                 1200                        

tta atc  caa gag aat gta gtt  ttg cct cag ata cat  aca gtg act        3654
Leu Ile  Gln Glu Asn Val Val  Leu Pro Gln Ile His  Thr Val Thr            
    1205                 1210                 1215                        

ggc act  aag aat ttc atg aag  aac ctt ttc tta ctg  agc act agg        3699
Gly Thr  Lys Asn Phe Met Lys  Asn Leu Phe Leu Leu  Ser Thr Arg            
    1220                 1225                 1230                        

caa aat  gta gaa ggt tca tat  gac ggg gca tat gct  cca gta ctt        3744
Gln Asn  Val Glu Gly Ser Tyr  Asp Gly Ala Tyr Ala  Pro Val Leu            
    1235                 1240                 1245                        

caa gat  ttt agg tca tta aat  gat tca aca aat aga  aca aag aaa        3789
Gln Asp  Phe Arg Ser Leu Asn  Asp Ser Thr Asn Arg  Thr Lys Lys            
    1250                 1255                 1260                        

cac aca  gct cat ttc tca aaa  aaa ggg gag gaa gaa  aac ttg gaa        3834
His Thr  Ala His Phe Ser Lys  Lys Gly Glu Glu Glu  Asn Leu Glu            
    1265                 1270                 1275                        

ggc ttg  gga aat caa acc aag  caa att gta gag aaa  tat gca tgc        3879
Gly Leu  Gly Asn Gln Thr Lys  Gln Ile Val Glu Lys  Tyr Ala Cys            
    1280                 1285                 1290                        

acc aca  agg ata tct cct aat  aca agc cag cag aat  ttt gtc acg        3924
Thr Thr  Arg Ile Ser Pro Asn  Thr Ser Gln Gln Asn  Phe Val Thr            
    1295                 1300                 1305                        

caa cgt  agt aag aga gct ttg  aaa caa ttc aga ctc  cca cta gaa        3969
Gln Arg  Ser Lys Arg Ala Leu  Lys Gln Phe Arg Leu  Pro Leu Glu            
    1310                 1315                 1320                        

gaa aca  gaa ctt gaa aaa agg  ata att gtg gat gac  acc tca acc        4014
Glu Thr  Glu Leu Glu Lys Arg  Ile Ile Val Asp Asp  Thr Ser Thr            
    1325                 1330                 1335                        

cag tgg  tcc aaa aac atg aaa  cat ttg acc ccg agc  acc ctc aca        4059
Gln Trp  Ser Lys Asn Met Lys  His Leu Thr Pro Ser  Thr Leu Thr            
    1340                 1345                 1350                        

cag ata  gac tac aat gag aag  gag aaa ggg gcc att  act cag tct        4104
Gln Ile  Asp Tyr Asn Glu Lys  Glu Lys Gly Ala Ile  Thr Gln Ser            
    1355                 1360                 1365                        

ccc tta  tca gat tgc ctt acg  agg agt cat agc atc  cct caa gca        4149
Pro Leu  Ser Asp Cys Leu Thr  Arg Ser His Ser Ile  Pro Gln Ala            
    1370                 1375                 1380                        

aat aga  tct cca tta ccc att  gca aag gta tca tca  ttt cca tct        4194
Asn Arg  Ser Pro Leu Pro Ile  Ala Lys Val Ser Ser  Phe Pro Ser            
    1385                 1390                 1395                        

att aga  cct ata tat ctg acc  agg gtc cta ttc caa  gac aac tct        4239
Ile Arg  Pro Ile Tyr Leu Thr  Arg Val Leu Phe Gln  Asp Asn Ser            
    1400                 1405                 1410                        

tct cat  ctt cca gca gca tct  tat aga aag aaa gat  tct ggg gtc        4284
Ser His  Leu Pro Ala Ala Ser  Tyr Arg Lys Lys Asp  Ser Gly Val            
    1415                 1420                 1425                        

caa gaa  agc agt cat ttc tta  caa gga gcc aaa aaa  aat aac ctt        4329
Gln Glu  Ser Ser His Phe Leu  Gln Gly Ala Lys Lys  Asn Asn Leu            
    1430                 1435                 1440                        

tct tta  gcc att cta acc ttg  gag atg act ggt gat  caa aga gag        4374
Ser Leu  Ala Ile Leu Thr Leu  Glu Met Thr Gly Asp  Gln Arg Glu            
    1445                 1450                 1455                        

gtt ggc  tcc ctg ggg aca agt  gcc aca aat tca gtc  aca tac aag        4419
Val Gly  Ser Leu Gly Thr Ser  Ala Thr Asn Ser Val  Thr Tyr Lys            
    1460                 1465                 1470                        

aaa gtt  gag aac act gtt ctc  ccg aaa cca gac ttg  ccc aaa aca        4464
Lys Val  Glu Asn Thr Val Leu  Pro Lys Pro Asp Leu  Pro Lys Thr            
    1475                 1480                 1485                        

tct ggc  aaa gtt gaa ttg ctt  cca aaa gtt cac att  tat cag aag        4509
Ser Gly  Lys Val Glu Leu Leu  Pro Lys Val His Ile  Tyr Gln Lys            
    1490                 1495                 1500                        

gac cta  ttc cct acg gaa act  agc aat ggg tct cct  ggc cat ctg        4554
Asp Leu  Phe Pro Thr Glu Thr  Ser Asn Gly Ser Pro  Gly His Leu            
    1505                 1510                 1515                        

gat ctc  gtg gaa ggg agc ctt  ctt cag gga aca gag  gga gcg att        4599
Asp Leu  Val Glu Gly Ser Leu  Leu Gln Gly Thr Glu  Gly Ala Ile            
    1520                 1525                 1530                        

aag tgg  aat gaa gca aac aga  cct gga aaa gtt ccc  ttt ctg aga        4644
Lys Trp  Asn Glu Ala Asn Arg  Pro Gly Lys Val Pro  Phe Leu Arg            
    1535                 1540                 1545                        

gta gca  aca gaa agc tct gca  aag act ccc tcc aag  cta ttg gat        4689
Val Ala  Thr Glu Ser Ser Ala  Lys Thr Pro Ser Lys  Leu Leu Asp            
    1550                 1555                 1560                        

cct ctt  gct tgg gat aac cac  tat ggt act cag ata  cca aaa gaa        4734
Pro Leu  Ala Trp Asp Asn His  Tyr Gly Thr Gln Ile  Pro Lys Glu            
    1565                 1570                 1575                        

gag tgg  aaa tcc caa gag aag  tca cca gaa aaa aca  gct ttt aag        4779
Glu Trp  Lys Ser Gln Glu Lys  Ser Pro Glu Lys Thr  Ala Phe Lys            
    1580                 1585                 1590                        

aaa aag  gat acc att ttg tcc  ctg aac gct tgt gaa  agc aat cat        4824
Lys Lys  Asp Thr Ile Leu Ser  Leu Asn Ala Cys Glu  Ser Asn His            
    1595                 1600                 1605                        

gca ata  gca gca ata aat gag  gga caa aat aag ccc  gaa ata gaa        4869
Ala Ile  Ala Ala Ile Asn Glu  Gly Gln Asn Lys Pro  Glu Ile Glu            
    1610                 1615                 1620                        

gtc acc  tgg gca aag caa ggt  agg act gaa agg ctg  tgc tct caa        4914
Val Thr  Trp Ala Lys Gln Gly  Arg Thr Glu Arg Leu  Cys Ser Gln            
    1625                 1630                 1635                        

aac cca  cca gtc ttg aaa cgc  cat caa cgg gaa ata  act cgt act        4959
Asn Pro  Pro Val Leu Lys Arg  His Gln Arg Glu Ile  Thr Arg Thr            
    1640                 1645                 1650                        

act ctt  cag tca gat caa gag  gaa att gac tat gat  gat acc ata        5004
Thr Leu  Gln Ser Asp Gln Glu  Glu Ile Asp Tyr Asp  Asp Thr Ile            
    1655                 1660                 1665                        

tca gtt  gaa atg aag aag gaa  gat ttt gac att tat  gat gag gat        5049
Ser Val  Glu Met Lys Lys Glu  Asp Phe Asp Ile Tyr  Asp Glu Asp            
    1670                 1675                 1680                        

gaa aat  cag agc ccc cgc agc  ttt caa aag aaa aca  cga cac tat        5094
Glu Asn  Gln Ser Pro Arg Ser  Phe Gln Lys Lys Thr  Arg His Tyr            
    1685                 1690                 1695                        

ttt att  gct gca gtg gag agg  ctc tgg gat tat ggg  atg agt agc        5139
Phe Ile  Ala Ala Val Glu Arg  Leu Trp Asp Tyr Gly  Met Ser Ser            
    1700                 1705                 1710                        

tcc cca  cat gtt cta aga aac  agg gct cag agt ggc  agt gtc cct        5184
Ser Pro  His Val Leu Arg Asn  Arg Ala Gln Ser Gly  Ser Val Pro            
    1715                 1720                 1725                        

cag ttc  aag aaa gtt gtt ttc  cag gaa ttt act gat  ggc tcc ttt        5229
Gln Phe  Lys Lys Val Val Phe  Gln Glu Phe Thr Asp  Gly Ser Phe            
    1730                 1735                 1740                        

act cag  ccc tta tac cgt gga  gaa cta aat gaa cat  ttg gga ctc        5274
Thr Gln  Pro Leu Tyr Arg Gly  Glu Leu Asn Glu His  Leu Gly Leu            
    1745                 1750                 1755                        

ctg ggg  cca tat ata aga gca  gaa gtt gaa gat aat  atc atg gta        5319
Leu Gly  Pro Tyr Ile Arg Ala  Glu Val Glu Asp Asn  Ile Met Val            
    1760                 1765                 1770                        

act ttc  aga aat cag gcc tct  cgt ccc tat tcc ttc  tat tct agc        5364
Thr Phe  Arg Asn Gln Ala Ser  Arg Pro Tyr Ser Phe  Tyr Ser Ser            
    1775                 1780                 1785                        

ctt att  tct tat gag gaa gat  cag agg caa gga gca  gaa cct aga        5409
Leu Ile  Ser Tyr Glu Glu Asp  Gln Arg Gln Gly Ala  Glu Pro Arg            
    1790                 1795                 1800                        

aaa aac  ttt gtc aag cct aat  gaa acc aaa act tac  ttt tgg aaa        5454
Lys Asn  Phe Val Lys Pro Asn  Glu Thr Lys Thr Tyr  Phe Trp Lys            
    1805                 1810                 1815                        

gtg caa  cat cat atg gca ccc  act aaa gat gag ttt  gac tgc aaa        5499
Val Gln  His His Met Ala Pro  Thr Lys Asp Glu Phe  Asp Cys Lys            
    1820                 1825                 1830                        

gcc tgg  gct tat ttc tct gat  gtt gac ctg gaa aaa  gat gtg cac        5544
Ala Trp  Ala Tyr Phe Ser Asp  Val Asp Leu Glu Lys  Asp Val His            
    1835                 1840                 1845                        

tca ggc  ctg att gga ccc ctt  ctg gtc tgc cac act  aac aca ctg        5589
Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys His Thr  Asn Thr Leu            
    1850                 1855                 1860                        

aac cct  gct cat ggg aga caa  gtg aca gta cag gaa  ttt gct ctg        5634
Asn Pro  Ala His Gly Arg Gln  Val Thr Val Gln Glu  Phe Ala Leu            
    1865                 1870                 1875                        

ttt ttc  acc atc ttt gat gag  acc aaa agc tgg tac  ttc act gaa        5679
Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu            
    1880                 1885                 1890                        

aat atg  gaa aga aac tgc agg  gct ccc tgc aat atc  cag atg gaa        5724
Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu            
    1895                 1900                 1905                        

gat ccc  act ttt aaa gag aat  tat cgc ttc cat gca  atc aat ggc        5769
Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly            
    1910                 1915                 1920                        

tac ata  atg gat aca cta cct  ggc tta gta atg gct  cag gat caa        5814
Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln            
    1925                 1930                 1935                        

agg att  cga tgg tat ctg ctc  agc atg ggc agc aat  gaa aac atc        5859
Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile            
    1940                 1945                 1950                        

cat tct  att cat ttc agt gga  cat gtg ttc act gta  cga aaa aaa        5904
His Ser  Ile His Phe Ser Gly  His Val Phe Thr Val  Arg Lys Lys            
    1955                 1960                 1965                        

gag gag  tat aaa atg gca ctg  tac aat ctc tat cca  ggt gtt ttt        5949
Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe            
    1970                 1975                 1980                        

gag aca  gtg gaa atg tta cca  tcc aaa gct gga att  tgg cgg gtg        5994
Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val            
    1985                 1990                 1995                        

gaa tgc  ctt att ggc gag cat  cta cat gct ggg atg  agc aca ctt        6039
Glu Cys  Leu Ile Gly Glu His  Leu His Ala Gly Met  Ser Thr Leu            
    2000                 2005                 2010                        

ttt ctg  gtg tac agc aat aag  tgt cag act ccc ctg  gga atg gct        6084
Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala            
    2015                 2020                 2025                        

tct gga  cac att aga gat ttt  cag att aca gct tca  gga caa tat        6129
Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr            
    2030                 2035                 2040                        

gga cag  tgg gcc cca aag ctg  gcc aga ctt cat tat  tcc gga tca        6174
Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser            
    2045                 2050                 2055                        

atc aat  gcc tgg agc acc aag  gag ccc ttt tct tgg  atc aag gtg        6219
Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val            
    2060                 2065                 2070                        

gat ctg  ttg gca cca atg att  att cac ggc atc aag  acc cag ggt        6264
Asp Leu  Leu Ala Pro Met Ile  Ile His Gly Ile Lys  Thr Gln Gly            
    2075                 2080                 2085                        

gcc cgt  cag aag ttc tcc agc  ctc tac atc tct cag  ttt atc atc        6309
Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile            
    2090                 2095                 2100                        

atg tat  agt ctt gat ggg aag  aag tgg cag act tat  cga gga aat        6354
Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn            
    2105                 2110                 2115                        

tcc act  gga acc tta atg gtc  ttc ttt ggc aat gtg  gat tca tct        6399
Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly Asn Val  Asp Ser Ser            
    2120                 2125                 2130                        

ggg ata  aaa cac aat att ttt  aac cct cca att att  gct cga tac        6444
Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr            
    2135                 2140                 2145                        

atc cgt  ttg cac cca act cat  tat agc att cgc agc  act ctt cgc        6489
Ile Arg  Leu His Pro Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg            
    2150                 2155                 2160                        

atg gag  ttg atg ggc tgt gat  tta aat agt tgc agc  atg cca ttg        6534
Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu            
    2165                 2170                 2175                        

gga atg  gag agt aaa gca ata  tca gat gca cag att  act gct tca        6579
Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser            
    2180                 2185                 2190                        

tcc tac  ttt acc aat atg ttt  gcc acc tgg tct cct  tca aaa gct        6624
Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala            
    2195                 2200                 2205                        

cga ctt  cac ctc caa ggg agg  agt aat gcc tgg aga  cct cag gtg        6669
Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val            
    2210                 2215                 2220                        

aat aat  cca aaa gag tgg ctg  caa gtg gac ttc cag  aag aca atg        6714
Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met            
    2225                 2230                 2235                        

aaa gtc  aca gga gta act act  cag gga gta aaa tct  ctg ctt acc        6759
Lys Val  Thr Gly Val Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr            
    2240                 2245                 2250                        

agc atg  tat gtg aag gag ttc  ctc atc tcc agc agt  caa gat ggc        6804
Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly            
    2255                 2260                 2265                        

cat cag  tgg act ctc ttt ttt  cag aat ggc aaa gta  aag gtt ttt        6849
His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe            
    2270                 2275                 2280                        

cag gga  aat caa gac tcc ttc  aca cct gtg gtg aac  tct cta gac        6894
Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp            
    2285                 2290                 2295                        

cca ccg  tta ctg act cgc tac  ctt cga att cac ccc  cag agt tgg        6939
Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp            
    2300                 2305                 2310                        

gtg cac  cag att gcc ctg agg  atg gag gtt ctg ggc  tgc gag gca        6984
Val His  Gln Ile Ala Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala            
    2315                 2320                 2325                        

cag gac  ctc tac                                                      6996
Gln Asp  Leu Tyr                                                          
    2330                                                                  


<210>  2
<211>  2332
<212>  PRT
<213>  homo sapiens

<400>  2

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Arg Ser Thr Arg 
            740                 745                 750         


Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys 
        755                 760                 765             


Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn 
    770                 775                 780                 


Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro 
785                 790                 795                 800 


His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe 
                805                 810                 815     


Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser 
            820                 825                 830         


Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val 
        835                 840                 845             


Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly 
    850                 855                 860                 


Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser 
865                 870                 875                 880 


Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala 
                885                 890                 895     


Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His 
            900                 905                 910         


Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro 
        915                 920                 925             


Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp 
    930                 935                 940                 


Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp 
945                 950                 955                 960 


Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys 
                965                 970                 975     


Arg Ala His Gly Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys 
            980                 985                 990         


Val Ser Ile Ser Leu Leu Lys Thr  Asn Lys Thr Ser Asn  Asn Ser Ala 
        995                 1000                 1005             


Thr Asn  Arg Lys Thr His Ile  Asp Gly Pro Ser Leu  Leu Ile Glu 
    1010                 1015                 1020             


Asn Ser  Pro Ser Val Trp Gln  Asn Ile Leu Glu Ser  Asp Thr Glu 
    1025                 1030                 1035             


Phe Lys  Lys Val Thr Pro Leu  Ile His Asp Arg Met  Leu Met Asp 
    1040                 1045                 1050             


Lys Asn  Ala Thr Ala Leu Arg  Leu Asn His Met Ser  Asn Lys Thr 
    1055                 1060                 1065             


Thr Ser  Ser Lys Asn Met Glu  Met Val Gln Gln Lys  Lys Glu Gly 
    1070                 1075                 1080             


Pro Ile  Pro Pro Asp Ala Gln  Asn Pro Asp Met Ser  Phe Phe Lys 
    1085                 1090                 1095             


Met Leu  Phe Leu Pro Glu Ser  Ala Arg Trp Ile Gln  Arg Thr His 
    1100                 1105                 1110             


Gly Lys  Asn Ser Leu Asn Ser  Gly Gln Gly Pro Ser  Pro Lys Gln 
    1115                 1120                 1125             


Leu Val  Ser Leu Gly Pro Glu  Lys Ser Val Glu Gly  Gln Asn Phe 
    1130                 1135                 1140             


Leu Ser  Glu Lys Asn Lys Val  Val Val Gly Lys Gly  Glu Phe Thr 
    1145                 1150                 1155             


Lys Asp  Val Gly Leu Lys Glu  Met Val Phe Pro Ser  Ser Arg Asn 
    1160                 1165                 1170             


Leu Phe  Leu Thr Asn Leu Asp  Asn Leu His Glu Asn  Asn Thr His 
    1175                 1180                 1185             


Asn Gln  Glu Lys Lys Ile Gln  Glu Glu Ile Glu Lys  Lys Glu Thr 
    1190                 1195                 1200             


Leu Ile  Gln Glu Asn Val Val  Leu Pro Gln Ile His  Thr Val Thr 
    1205                 1210                 1215             


Gly Thr  Lys Asn Phe Met Lys  Asn Leu Phe Leu Leu  Ser Thr Arg 
    1220                 1225                 1230             


Gln Asn  Val Glu Gly Ser Tyr  Asp Gly Ala Tyr Ala  Pro Val Leu 
    1235                 1240                 1245             


Gln Asp  Phe Arg Ser Leu Asn  Asp Ser Thr Asn Arg  Thr Lys Lys 
    1250                 1255                 1260             


His Thr  Ala His Phe Ser Lys  Lys Gly Glu Glu Glu  Asn Leu Glu 
    1265                 1270                 1275             


Gly Leu  Gly Asn Gln Thr Lys  Gln Ile Val Glu Lys  Tyr Ala Cys 
    1280                 1285                 1290             


Thr Thr  Arg Ile Ser Pro Asn  Thr Ser Gln Gln Asn  Phe Val Thr 
    1295                 1300                 1305             


Gln Arg  Ser Lys Arg Ala Leu  Lys Gln Phe Arg Leu  Pro Leu Glu 
    1310                 1315                 1320             


Glu Thr  Glu Leu Glu Lys Arg  Ile Ile Val Asp Asp  Thr Ser Thr 
    1325                 1330                 1335             


Gln Trp  Ser Lys Asn Met Lys  His Leu Thr Pro Ser  Thr Leu Thr 
    1340                 1345                 1350             


Gln Ile  Asp Tyr Asn Glu Lys  Glu Lys Gly Ala Ile  Thr Gln Ser 
    1355                 1360                 1365             


Pro Leu  Ser Asp Cys Leu Thr  Arg Ser His Ser Ile  Pro Gln Ala 
    1370                 1375                 1380             


Asn Arg  Ser Pro Leu Pro Ile  Ala Lys Val Ser Ser  Phe Pro Ser 
    1385                 1390                 1395             


Ile Arg  Pro Ile Tyr Leu Thr  Arg Val Leu Phe Gln  Asp Asn Ser 
    1400                 1405                 1410             


Ser His  Leu Pro Ala Ala Ser  Tyr Arg Lys Lys Asp  Ser Gly Val 
    1415                 1420                 1425             


Gln Glu  Ser Ser His Phe Leu  Gln Gly Ala Lys Lys  Asn Asn Leu 
    1430                 1435                 1440             


Ser Leu  Ala Ile Leu Thr Leu  Glu Met Thr Gly Asp  Gln Arg Glu 
    1445                 1450                 1455             


Val Gly  Ser Leu Gly Thr Ser  Ala Thr Asn Ser Val  Thr Tyr Lys 
    1460                 1465                 1470             


Lys Val  Glu Asn Thr Val Leu  Pro Lys Pro Asp Leu  Pro Lys Thr 
    1475                 1480                 1485             


Ser Gly  Lys Val Glu Leu Leu  Pro Lys Val His Ile  Tyr Gln Lys 
    1490                 1495                 1500             


Asp Leu  Phe Pro Thr Glu Thr  Ser Asn Gly Ser Pro  Gly His Leu 
    1505                 1510                 1515             


Asp Leu  Val Glu Gly Ser Leu  Leu Gln Gly Thr Glu  Gly Ala Ile 
    1520                 1525                 1530             


Lys Trp  Asn Glu Ala Asn Arg  Pro Gly Lys Val Pro  Phe Leu Arg 
    1535                 1540                 1545             


Val Ala  Thr Glu Ser Ser Ala  Lys Thr Pro Ser Lys  Leu Leu Asp 
    1550                 1555                 1560             


Pro Leu  Ala Trp Asp Asn His  Tyr Gly Thr Gln Ile  Pro Lys Glu 
    1565                 1570                 1575             


Glu Trp  Lys Ser Gln Glu Lys  Ser Pro Glu Lys Thr  Ala Phe Lys 
    1580                 1585                 1590             


Lys Lys  Asp Thr Ile Leu Ser  Leu Asn Ala Cys Glu  Ser Asn His 
    1595                 1600                 1605             


Ala Ile  Ala Ala Ile Asn Glu  Gly Gln Asn Lys Pro  Glu Ile Glu 
    1610                 1615                 1620             


Val Thr  Trp Ala Lys Gln Gly  Arg Thr Glu Arg Leu  Cys Ser Gln 
    1625                 1630                 1635             


Asn Pro  Pro Val Leu Lys Arg  His Gln Arg Glu Ile  Thr Arg Thr 
    1640                 1645                 1650             


Thr Leu  Gln Ser Asp Gln Glu  Glu Ile Asp Tyr Asp  Asp Thr Ile 
    1655                 1660                 1665             


Ser Val  Glu Met Lys Lys Glu  Asp Phe Asp Ile Tyr  Asp Glu Asp 
    1670                 1675                 1680             


Glu Asn  Gln Ser Pro Arg Ser  Phe Gln Lys Lys Thr  Arg His Tyr 
    1685                 1690                 1695             


Phe Ile  Ala Ala Val Glu Arg  Leu Trp Asp Tyr Gly  Met Ser Ser 
    1700                 1705                 1710             


Ser Pro  His Val Leu Arg Asn  Arg Ala Gln Ser Gly  Ser Val Pro 
    1715                 1720                 1725             


Gln Phe  Lys Lys Val Val Phe  Gln Glu Phe Thr Asp  Gly Ser Phe 
    1730                 1735                 1740             


Thr Gln  Pro Leu Tyr Arg Gly  Glu Leu Asn Glu His  Leu Gly Leu 
    1745                 1750                 1755             


Leu Gly  Pro Tyr Ile Arg Ala  Glu Val Glu Asp Asn  Ile Met Val 
    1760                 1765                 1770             


Thr Phe  Arg Asn Gln Ala Ser  Arg Pro Tyr Ser Phe  Tyr Ser Ser 
    1775                 1780                 1785             


Leu Ile  Ser Tyr Glu Glu Asp  Gln Arg Gln Gly Ala  Glu Pro Arg 
    1790                 1795                 1800             


Lys Asn  Phe Val Lys Pro Asn  Glu Thr Lys Thr Tyr  Phe Trp Lys 
    1805                 1810                 1815             


Val Gln  His His Met Ala Pro  Thr Lys Asp Glu Phe  Asp Cys Lys 
    1820                 1825                 1830             


Ala Trp  Ala Tyr Phe Ser Asp  Val Asp Leu Glu Lys  Asp Val His 
    1835                 1840                 1845             


Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys His Thr  Asn Thr Leu 
    1850                 1855                 1860             


Asn Pro  Ala His Gly Arg Gln  Val Thr Val Gln Glu  Phe Ala Leu 
    1865                 1870                 1875             


Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu 
    1880                 1885                 1890             


Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu 
    1895                 1900                 1905             


Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly 
    1910                 1915                 1920             


Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln 
    1925                 1930                 1935             


Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile 
    1940                 1945                 1950             


His Ser  Ile His Phe Ser Gly  His Val Phe Thr Val  Arg Lys Lys 
    1955                 1960                 1965             


Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe 
    1970                 1975                 1980             


Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val 
    1985                 1990                 1995             


Glu Cys  Leu Ile Gly Glu His  Leu His Ala Gly Met  Ser Thr Leu 
    2000                 2005                 2010             


Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala 
    2015                 2020                 2025             


Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr 
    2030                 2035                 2040             


Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser 
    2045                 2050                 2055             


Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val 
    2060                 2065                 2070             


Asp Leu  Leu Ala Pro Met Ile  Ile His Gly Ile Lys  Thr Gln Gly 
    2075                 2080                 2085             


Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile 
    2090                 2095                 2100             


Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn 
    2105                 2110                 2115             


Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly Asn Val  Asp Ser Ser 
    2120                 2125                 2130             


Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr 
    2135                 2140                 2145             


Ile Arg  Leu His Pro Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg 
    2150                 2155                 2160             


Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu 
    2165                 2170                 2175             


Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser 
    2180                 2185                 2190             


Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala 
    2195                 2200                 2205             


Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val 
    2210                 2215                 2220             


Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met 
    2225                 2230                 2235             


Lys Val  Thr Gly Val Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr 
    2240                 2245                 2250             


Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly 
    2255                 2260                 2265             


His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe 
    2270                 2275                 2280             


Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp 
    2285                 2290                 2295             


Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp 
    2300                 2305                 2310             


Val His  Gln Ile Ala Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala 
    2315                 2320                 2325             


Gln Asp  Leu Tyr 
    2330         


