                         SEQUENCE LISTING

<110>  EFFIMUNE
       INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
 
<120>  ANTIBODIES DIRECTED AGAINST THE ALPHA CHAIN OF IL7 RECEPTOR - 
       THEIR USE FOR THE PREPARATION OF DRUG CANDIDATES

<130>  B09614A-AD/KN

<140>  PCT/EP XXXXXXX
<141>  2012-10-04

<150>  EP 11306353.1
<151>  2011-10-19

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  423
<212>  DNA
<213>  RAT MD707-1/VH


<220>
<221>  CDS
<222>  (1)..(423)

<400>  1
atg ttg gtg ctg cag tgg gtt ttg gtg act gct ctt ttt caa ggt gtg         48
Met Leu Val Leu Gln Trp Val Leu Val Thr Ala Leu Phe Gln Gly Val           
1               5                   10                  15                

cat tgt gcg gtg cac ctt gtt gag tct ggt gga gga ttg gtg cag cct         96
His Cys Ala Val His Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro           
            20                  25                  30                    

aag gag tca ttg aaa atc tca tgt gca gcc tct gga ttc acc ttc agt        144
Lys Glu Ser Leu Lys Ile Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser           
        35                  40                  45                        

aat gct gcc atg ttc tgg gtc cgc cag gct cca gga aag ggt ctg gaa        192
Asn Ala Ala Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu           
    50                  55                  60                            

tgg gtt gct cgc ata aga act aaa gct aat aat tat gca aca tat tat        240
Trp Val Ala Arg Ile Arg Thr Lys Ala Asn Asn Tyr Ala Thr Tyr Tyr           
65                  70                  75                  80            

gct gat tca gtg aaa ggc aga ttc acc atc tcc aga gat gat tca aaa        288
Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys           
                85                  90                  95                

agc atg gtc tac cta caa atg gat aac gtg aaa act gac gac aca gcc        336
Ser Met Val Tyr Leu Gln Met Asp Asn Val Lys Thr Asp Asp Thr Ala           
            100                 105                 110                   

atg tat tat tgt ata gta gta gtt ctc aca aca act agg gac tac ttt        384
Met Tyr Tyr Cys Ile Val Val Val Leu Thr Thr Thr Arg Asp Tyr Phe           
        115                 120                 125                       

gat tac tgg ggc caa gga gtc atg gtc aca gtc tcc tca                    423
Asp Tyr Trp Gly Gln Gly Val Met Val Thr Val Ser Ser                       
    130                 135                 140                           


<210>  2
<211>  141
<212>  PRT
<213>  RAT MD707-1/VH

<400>  2

Met Leu Val Leu Gln Trp Val Leu Val Thr Ala Leu Phe Gln Gly Val 
1               5                   10                  15      


His Cys Ala Val His Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          


Lys Glu Ser Leu Lys Ile Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
        35                  40                  45              


Asn Ala Ala Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Val Ala Arg Ile Arg Thr Lys Ala Asn Asn Tyr Ala Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
                85                  90                  95      


Ser Met Val Tyr Leu Gln Met Asp Asn Val Lys Thr Asp Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ile Val Val Val Leu Thr Thr Thr Arg Asp Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Val Met Val Thr Val Ser Ser 
    130                 135                 140     


<210>  3
<211>  399
<212>  DNA
<213>  RAT MD707-1/VL


<220>
<221>  CDS
<222>  (1)..(399)

<400>  3
atg aag ttt cct gct cag ttt ctt gga ctg ata gtg ctc tgt att cct         48
Met Lys Phe Pro Ala Gln Phe Leu Gly Leu Ile Val Leu Cys Ile Pro           
1               5                   10                  15                

gga gcc act ggg gat att gtg ttg act caa gct cca ctc tct gta tct         96
Gly Ala Thr Gly Asp Ile Val Leu Thr Gln Ala Pro Leu Ser Val Ser           
            20                  25                  30                    

gtc act cct gga gag tca gct tcc atc tcc tgc agg tct agt cag agt        144
Val Thr Pro Gly Glu Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser           
        35                  40                  45                        

ctg ctg act gtt aag ggc atc act tcc ttg tat tgg ttc ctt cag aag        192
Leu Leu Thr Val Lys Gly Ile Thr Ser Leu Tyr Trp Phe Leu Gln Lys           
    50                  55                  60                            

cca gga aag tct cct caa ctc ctg atg tat cgg atg tcc aac ctt gcc        240
Pro Gly Lys Ser Pro Gln Leu Leu Met Tyr Arg Met Ser Asn Leu Ala           
65                  70                  75                  80            

tca gga gtt cca gac agg ttt cgt ggc agt ggg tca gaa aca gat ttt        288
Ser Gly Val Pro Asp Arg Phe Arg Gly Ser Gly Ser Glu Thr Asp Phe           
                85                  90                  95                

aca ctg aaa atc agt aag gtg gag act gag gat gtt ggc gtt tat tac        336
Thr Leu Lys Ile Ser Lys Val Glu Thr Glu Asp Val Gly Val Tyr Tyr           
            100                 105                 110                   

tgt gca cag ttt ctt gag tat cct cac acg ttt gga gct ggg acc aag        384
Cys Ala Gln Phe Leu Glu Tyr Pro His Thr Phe Gly Ala Gly Thr Lys           
        115                 120                 125                       

ctg gaa ctg aaa cgg                                                    399
Leu Glu Leu Lys Arg                                                       
    130                                                                   


<210>  4
<211>  133
<212>  PRT
<213>  RAT MD707-1/VL

<400>  4

Met Lys Phe Pro Ala Gln Phe Leu Gly Leu Ile Val Leu Cys Ile Pro 
1               5                   10                  15      


Gly Ala Thr Gly Asp Ile Val Leu Thr Gln Ala Pro Leu Ser Val Ser 
            20                  25                  30          


Val Thr Pro Gly Glu Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Thr Val Lys Gly Ile Thr Ser Leu Tyr Trp Phe Leu Gln Lys 
    50                  55                  60                  


Pro Gly Lys Ser Pro Gln Leu Leu Met Tyr Arg Met Ser Asn Leu Ala 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Arg Gly Ser Gly Ser Glu Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Lys Val Glu Thr Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Ala Gln Phe Leu Glu Tyr Pro His Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Leu Lys Arg 
    130             


<210>  5
<211>  27
<212>  DNA
<213>  RAT MD707-1/VHCDR1


<220>
<221>  CDS
<222>  (1)..(27)

<400>  5
ttc acc ttc agt aat gct gcc atg ttc                                     27
Phe Thr Phe Ser Asn Ala Ala Met Phe                                       
1               5                                                         


<210>  6
<211>  9
<212>  PRT
<213>  RAT MD707-1/VHCDR1

<400>  6

Phe Thr Phe Ser Asn Ala Ala Met Phe 
1               5                   


<210>  7
<211>  57
<212>  DNA
<213>  RAT MD707-1/VHCDR2


<220>
<221>  CDS
<222>  (1)..(57)

<400>  7
cgc ata aga act aaa gct aat aat tat gca aca tat tat gct gat tca         48
Arg Ile Arg Thr Lys Ala Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser           
1               5                   10                  15                

gtg aaa ggc                                                             57
Val Lys Gly                                                               
                                                                          


<210>  8
<211>  19
<212>  PRT
<213>  RAT MD707-1/VHCDR2

<400>  8

Arg Ile Arg Thr Lys Ala Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  9
<211>  36
<212>  DNA
<213>  RAT MD707-1/VHCDR3


<220>
<221>  CDS
<222>  (1)..(36)

<400>  9
gta gtt ctc aca aca act agg gac tac ttt gat tac                         36
Val Val Leu Thr Thr Thr Arg Asp Tyr Phe Asp Tyr                           
1               5                   10                                    


<210>  10
<211>  12
<212>  PRT
<213>  RAT MD707-1/VHCDR3

<400>  10

Val Val Leu Thr Thr Thr Arg Asp Tyr Phe Asp Tyr 
1               5                   10          


<210>  11
<211>  48
<212>  DNA
<213>  RAT MD707-1/VLCDR1


<220>
<221>  CDS
<222>  (1)..(48)

<400>  11
agg tct agt cag agt ctg ctg act gtt aag ggc atc act tcc ttg tat         48
Arg Ser Ser Gln Ser Leu Leu Thr Val Lys Gly Ile Thr Ser Leu Tyr           
1               5                   10                  15                


<210>  12
<211>  16
<212>  PRT
<213>  RAT MD707-1/VLCDR1

<400>  12

Arg Ser Ser Gln Ser Leu Leu Thr Val Lys Gly Ile Thr Ser Leu Tyr 
1               5                   10                  15      


<210>  13
<211>  21
<212>  DNA
<213>  RAT MD707-1/VLCDR2


<220>
<221>  CDS
<222>  (1)..(21)

<400>  13
cgg atg tcc aac ctt gcc tca                                             21
Arg Met Ser Asn Leu Ala Ser                                               
1               5                                                         


<210>  14
<211>  7
<212>  PRT
<213>  RAT MD707-1/VLCDR2

<400>  14

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  15
<211>  27
<212>  DNA
<213>  RAT MD707-1/VLCDR3


<220>
<221>  CDS
<222>  (1)..(27)

<400>  15
gca cag ttt ctt gag tat cct cac acg                                     27
Ala Gln Phe Leu Glu Tyr Pro His Thr                                       
1               5                                                         


<210>  16
<211>  9
<212>  PRT
<213>  RAT MD707-1/VLCDR3

<400>  16

Ala Gln Phe Leu Glu Tyr Pro His Thr 
1               5                   


<210>  17
<211>  423
<212>  DNA
<213>  RAT MD707-3/VH


<220>
<221>  CDS
<222>  (1)..(423)

<400>  17
atg ttg gtg ctg cag tgg gtt ttg gtg act gct ctt ttt caa ggt gtg         48
Met Leu Val Leu Gln Trp Val Leu Val Thr Ala Leu Phe Gln Gly Val           
1               5                   10                  15                

cat tgt gcg gtg cac ctt gtt gag tct ggt gga gga ttg gtg cag cct         96
His Cys Ala Val His Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro           
            20                  25                  30                    

aag gag tca ttg aaa atc tca tgt gca gcc tct gga ttc acc ttc agt        144
Lys Glu Ser Leu Lys Ile Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser           
        35                  40                  45                        

aat gct gcc atg tac tgg gtc cgc cag gct cca gga aag ggt ctg gaa        192
Asn Ala Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu           
    50                  55                  60                            

tgg gtt gct cgc ata aga act aaa gct aat aat tat gca aca tat tat        240
Trp Val Ala Arg Ile Arg Thr Lys Ala Asn Asn Tyr Ala Thr Tyr Tyr           
65                  70                  75                  80            

gct gaa tca gtg aaa ggc aga ttc acc atc tcc aga gat gat tca aaa        288
Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys           
                85                  90                  95                

agc atg gtc tac cta caa atg gat aac gtg aaa act gac gac aca gcc        336
Ser Met Val Tyr Leu Gln Met Asp Asn Val Lys Thr Asp Asp Thr Ala           
            100                 105                 110                   

atg tat tac tgt ata gta gta gtt ctc aca aca act agg gac tac ttt        384
Met Tyr Tyr Cys Ile Val Val Val Leu Thr Thr Thr Arg Asp Tyr Phe           
        115                 120                 125                       

gat tac tgg ggc caa gga gtc atg gtc aca gtc tcc tca                    423
Asp Tyr Trp Gly Gln Gly Val Met Val Thr Val Ser Ser                       
    130                 135                 140                           


<210>  18
<211>  141
<212>  PRT
<213>  RAT MD707-3/VH

<400>  18

Met Leu Val Leu Gln Trp Val Leu Val Thr Ala Leu Phe Gln Gly Val 
1               5                   10                  15      


His Cys Ala Val His Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          


Lys Glu Ser Leu Lys Ile Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
        35                  40                  45              


Asn Ala Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Val Ala Arg Ile Arg Thr Lys Ala Asn Asn Tyr Ala Thr Tyr Tyr 
65                  70                  75                  80  


Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
                85                  90                  95      


Ser Met Val Tyr Leu Gln Met Asp Asn Val Lys Thr Asp Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ile Val Val Val Leu Thr Thr Thr Arg Asp Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Val Met Val Thr Val Ser Ser 
    130                 135                 140     


<210>  19
<211>  399
<212>  DNA
<213>  RAT MD707-3/VL


<220>
<221>  CDS
<222>  (1)..(399)

<400>  19
atg aag ttt cct gct cag ttt ctt gga ctg ata gtg ctc tgt att cct         48
Met Lys Phe Pro Ala Gln Phe Leu Gly Leu Ile Val Leu Cys Ile Pro           
1               5                   10                  15                

gga gcc act ggg gat att gtg ttg act caa gct cca ctc tct gta tct         96
Gly Ala Thr Gly Asp Ile Val Leu Thr Gln Ala Pro Leu Ser Val Ser           
            20                  25                  30                    

gtc act cct gga gag tca gct tcc atc tcc tgc agg tct agt cag agt        144
Val Thr Pro Gly Glu Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser           
        35                  40                  45                        

ctg cta act gtt aag ggc atc act tcc ttg tat tgg ttc ctt cag aag        192
Leu Leu Thr Val Lys Gly Ile Thr Ser Leu Tyr Trp Phe Leu Gln Lys           
    50                  55                  60                            

cca gga aag tct cct caa ctc ctg ata tat cgg atg tcc aac ctt gcc        240
Pro Gly Lys Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala           
65                  70                  75                  80            

tca gga gtt cca gac agg ttt cgt ggc agt ggg tca gaa aca gat ttt        288
Ser Gly Val Pro Asp Arg Phe Arg Gly Ser Gly Ser Glu Thr Asp Phe           
                85                  90                  95                

aca ctg aaa atc agt aag gtg gag act gag gat gtt ggc gtt tat tac        336
Thr Leu Lys Ile Ser Lys Val Glu Thr Glu Asp Val Gly Val Tyr Tyr           
            100                 105                 110                   

tgt gca cag ttt ctt gag tat cct cac acg ttt gga gct ggg acc aag        384
Cys Ala Gln Phe Leu Glu Tyr Pro His Thr Phe Gly Ala Gly Thr Lys           
        115                 120                 125                       

ctg gaa ctg aaa cgg                                                    399
Leu Glu Leu Lys Arg                                                       
    130                                                                   


<210>  20
<211>  133
<212>  PRT
<213>  RAT MD707-3/VL

<400>  20

Met Lys Phe Pro Ala Gln Phe Leu Gly Leu Ile Val Leu Cys Ile Pro 
1               5                   10                  15      


Gly Ala Thr Gly Asp Ile Val Leu Thr Gln Ala Pro Leu Ser Val Ser 
            20                  25                  30          


Val Thr Pro Gly Glu Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Thr Val Lys Gly Ile Thr Ser Leu Tyr Trp Phe Leu Gln Lys 
    50                  55                  60                  


Pro Gly Lys Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Arg Gly Ser Gly Ser Glu Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Lys Val Glu Thr Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Ala Gln Phe Leu Glu Tyr Pro His Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Leu Lys Arg 
    130             


<210>  21
<211>  27
<212>  DNA
<213>  RAT MD707-3/VHCDR1


<220>
<221>  CDS
<222>  (1)..(27)

<400>  21
ttc acc ttc agt aat gct gcc atg tac                                     27
Phe Thr Phe Ser Asn Ala Ala Met Tyr                                       
1               5                                                         


<210>  22
<211>  9
<212>  PRT
<213>  RAT MD707-3/VHCDR1

<400>  22

Phe Thr Phe Ser Asn Ala Ala Met Tyr 
1               5                   


<210>  23
<211>  57
<212>  DNA
<213>  RAT MD707-3/VHCDR2


<220>
<221>  CDS
<222>  (1)..(57)

<400>  23
cgc ata aga act aaa gct aat aat tat gca aca tat tat gct gaa tca         48
Arg Ile Arg Thr Lys Ala Asn Asn Tyr Ala Thr Tyr Tyr Ala Glu Ser           
1               5                   10                  15                

gtg aaa ggc                                                             57
Val Lys Gly                                                               
                                                                          


<210>  24
<211>  19
<212>  PRT
<213>  RAT MD707-3/VHCDR2

<400>  24

Arg Ile Arg Thr Lys Ala Asn Asn Tyr Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  25
<211>  36
<212>  DNA
<213>  RAT MD707-3/VHCDR3


<220>
<221>  CDS
<222>  (1)..(36)

<400>  25
gta gtt ctc aca aca act agg gac tac ttt gat tac                         36
Val Val Leu Thr Thr Thr Arg Asp Tyr Phe Asp Tyr                           
1               5                   10                                    


<210>  26
<211>  12
<212>  PRT
<213>  RAT MD707-3/VHCDR3

<400>  26

Val Val Leu Thr Thr Thr Arg Asp Tyr Phe Asp Tyr 
1               5                   10          


<210>  27
<211>  48
<212>  DNA
<213>  RAT MD707-3/VLCDR1


<220>
<221>  CDS
<222>  (1)..(48)

<400>  27
agg tct agt cag agt ctg cta act gtt aag ggc atc act tcc ttg tat         48
Arg Ser Ser Gln Ser Leu Leu Thr Val Lys Gly Ile Thr Ser Leu Tyr           
1               5                   10                  15                


<210>  28
<211>  16
<212>  PRT
<213>  RAT MD707-3/VLCDR1

<400>  28

Arg Ser Ser Gln Ser Leu Leu Thr Val Lys Gly Ile Thr Ser Leu Tyr 
1               5                   10                  15      


<210>  29
<211>  21
<212>  DNA
<213>  RAT MD707-3/VLCDR2


<220>
<221>  CDS
<222>  (1)..(21)

<400>  29
cgg atg tcc aac ctt gcc tca                                             21
Arg Met Ser Asn Leu Ala Ser                                               
1               5                                                         


<210>  30
<211>  7
<212>  PRT
<213>  RAT MD707-3/VLCDR2

<400>  30

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  31
<211>  27
<212>  DNA
<213>  RAT MD707-3/VLCDR3


<220>
<221>  CDS
<222>  (1)..(27)

<400>  31
gca cag ttt ctt gag tat cct cac acg                                     27
Ala Gln Phe Leu Glu Tyr Pro His Thr                                       
1               5                                                         


<210>  32
<211>  9
<212>  PRT
<213>  RAT MD707-3/VLCDR3

<400>  32

Ala Gln Phe Leu Glu Tyr Pro His Thr 
1               5                   


<210>  33
<211>  405
<212>  DNA
<213>  RAT MD707-13/VH


<220>
<221>  CDS
<222>  (1)..(405)

<400>  33
atg gct gtc ctg gtg ctg ttg ctc tgc ctg ttg ata ttt cca agc tgt         48
Met Ala Val Leu Val Leu Leu Leu Cys Leu Leu Ile Phe Pro Ser Cys           
1               5                   10                  15                

gtc ctg tcc caa gtg caa cta aag gag tca gga cct ggt ctg gta cag         96
Val Leu Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln           
            20                  25                  30                    

cca tca cag acc ctg tct ctc acc tgc act gtc tct ggg tta tca tta        144
Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Leu Ser Leu           
        35                  40                  45                        

ccc aac aat aat ata gcc tgg att cgg cag tct cca gga aag ggt cta        192
Pro Asn Asn Asn Ile Ala Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu           
    50                  55                  60                            

gag tgg atg gga gta ata tgg agt aat gga gac aca gat tat aat tca        240
Glu Trp Met Gly Val Ile Trp Ser Asn Gly Asp Thr Asp Tyr Asn Ser           
65                  70                  75                  80            

gct atc aga tcc cga ctg agc atc agc agg gac tcc tcg aag agc caa        288
Ala Ile Arg Ser Arg Leu Ser Ile Ser Arg Asp Ser Ser Lys Ser Gln           
                85                  90                  95                

gtc ttc tta agg atg aac agt ctg caa tct gaa gac aca gcc atg tac        336
Val Phe Leu Arg Met Asn Ser Leu Gln Ser Glu Asp Thr Ala Met Tyr           
            100                 105                 110                   

ttc tgt gcc aga gag ggg atg aca act ctt gat tac tgg ggc caa gga        384
Phe Cys Ala Arg Glu Gly Met Thr Thr Leu Asp Tyr Trp Gly Gln Gly           
        115                 120                 125                       

gtc gtg gtc aca gtc tcc tca                                            405
Val Val Val Thr Val Ser Ser                                               
    130                 135                                               


<210>  34
<211>  135
<212>  PRT
<213>  RAT MD707-13/VH

<400>  34

Met Ala Val Leu Val Leu Leu Leu Cys Leu Leu Ile Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Leu Ser Leu 
        35                  40                  45              


Pro Asn Asn Asn Ile Ala Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Val Ile Trp Ser Asn Gly Asp Thr Asp Tyr Asn Ser 
65                  70                  75                  80  


Ala Ile Arg Ser Arg Leu Ser Ile Ser Arg Asp Ser Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Leu Arg Met Asn Ser Leu Gln Ser Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Phe Cys Ala Arg Glu Gly Met Thr Thr Leu Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Val Val Val Thr Val Ser Ser 
    130                 135 


<210>  35
<211>  387
<212>  DNA
<213>  RAT MD707-13/VL


<220>
<221>  CDS
<222>  (1)..(387)

<400>  35
atg gat ttt cag gtg cag agt ttc agc ctc ctg cta atc agt atc aca         48
Met Asp Phe Gln Val Gln Ser Phe Ser Leu Leu Leu Ile Ser Ile Thr           
1               5                   10                  15                

gtc ata gtg tcc agt gga gaa att gtg ctc acc cag tct cca aca acc         96
Val Ile Val Ser Ser Gly Glu Ile Val Leu Thr Gln Ser Pro Thr Thr           
            20                  25                  30                    

atg gct gcg tct cca gga gag aag gtc acc atc acc tgc cgt gcc agc        144
Met Ala Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Arg Ala Ser           
        35                  40                  45                        

tca agt gta agc tac atg cac tgg ttc cag cag aag tca ggt tcc tcc        192
Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Ser Gly Ser Ser           
    50                  55                  60                            

ccc aaa ccc tgg att tat gac tca tcc gac ctg gct tct gga gtc cca        240
Pro Lys Pro Trp Ile Tyr Asp Ser Ser Asp Leu Ala Ser Gly Val Pro           
65                  70                  75                  80            

gat cgc ttc agt ggc agt ggg tct ggg acc tct tat tct ctc aca atc        288
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile           
                85                  90                  95                

agc tcc atg gag gct gaa gat gct gct act tat tac tgt ctg cag agg        336
Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gln Arg           
            100                 105                 110                   

agt agt tac cca cgg acg ttc ggt gga ggc acc aag ctg gaa ttg aaa        384
Ser Ser Tyr Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys           
        115                 120                 125                       

cgg                                                                    387
Arg                                                                       
                                                                          


<210>  36
<211>  129
<212>  PRT
<213>  RAT MD707-13/VL

<400>  36

Met Asp Phe Gln Val Gln Ser Phe Ser Leu Leu Leu Ile Ser Ile Thr 
1               5                   10                  15      


Val Ile Val Ser Ser Gly Glu Ile Val Leu Thr Gln Ser Pro Thr Thr 
            20                  25                  30          


Met Ala Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Ser Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Asp Ser Ser Asp Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gln Arg 
            100                 105                 110         


Ser Ser Tyr Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Arg 
    


<210>  37
<211>  27
<212>  DNA
<213>  RAT MD707-13/VHCDR1


<220>
<221>  CDS
<222>  (1)..(27)

<400>  37
tta tca tta ccc aac aat aat ata gcc                                     27
Leu Ser Leu Pro Asn Asn Asn Ile Ala                                       
1               5                                                         


<210>  38
<211>  9
<212>  PRT
<213>  RAT MD707-13/VHCDR1

<400>  38

Leu Ser Leu Pro Asn Asn Asn Ile Ala 
1               5                   


<210>  39
<211>  48
<212>  DNA
<213>  RAT MD707-13/VHCDR2


<220>
<221>  CDS
<222>  (1)..(48)

<400>  39
gta ata tgg agt aat gga gac aca gat tat aat tca gct atc aga tcc         48
Val Ile Trp Ser Asn Gly Asp Thr Asp Tyr Asn Ser Ala Ile Arg Ser           
1               5                   10                  15                


<210>  40
<211>  16
<212>  PRT
<213>  RAT MD707-13/VHCDR2

<400>  40

Val Ile Trp Ser Asn Gly Asp Thr Asp Tyr Asn Ser Ala Ile Arg Ser 
1               5                   10                  15      


<210>  41
<211>  24
<212>  DNA
<213>  RAT MD707-13/VHCDR3


<220>
<221>  CDS
<222>  (1)..(24)

<400>  41
gag ggg atg aca act ctt gat tac                                         24
Glu Gly Met Thr Thr Leu Asp Tyr                                           
1               5                                                         


<210>  42
<211>  8
<212>  PRT
<213>  RAT MD707-13/VHCDR3

<400>  42

Glu Gly Met Thr Thr Leu Asp Tyr 
1               5               


<210>  43
<211>  30
<212>  DNA
<213>  RAT MD707-13/VLCDR1


<220>
<221>  CDS
<222>  (1)..(30)

<400>  43
cgt gcc agc tca agt gta agc tac atg cac                                 30
Arg Ala Ser Ser Ser Val Ser Tyr Met His                                   
1               5                   10                                    


<210>  44
<211>  10
<212>  PRT
<213>  RAT MD707-13/VLCDR1

<400>  44

Arg Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  45
<211>  21
<212>  DNA
<213>  RAT MD707-13/VLCDR2


<220>
<221>  CDS
<222>  (1)..(21)

<400>  45
gac tca tcc gac ctg gct tct                                             21
Asp Ser Ser Asp Leu Ala Ser                                               
1               5                                                         


<210>  46
<211>  7
<212>  PRT
<213>  RAT MD707-13/VLCDR2

<400>  46

Asp Ser Ser Asp Leu Ala Ser 
1               5           


<210>  47
<211>  27
<212>  DNA
<213>  RAT MD707-13/VLCDR3


<220>
<221>  CDS
<222>  (1)..(27)

<400>  47
ctg cag agg agt agt tac cca cgg acg                                     27
Leu Gln Arg Ser Ser Tyr Pro Arg Thr                                       
1               5                                                         


<210>  48
<211>  9
<212>  PRT
<213>  RAT MD707-13/VLCDR3

<400>  48

Leu Gln Arg Ser Ser Tyr Pro Arg Thr 
1               5                   


