                         SEQUENCE LISTING

<110>  THERATECHNOLOGIES, INC
       BELIVEAU, Richard
       MICHAUD-LEVESQUE, Jonathan
       PERI, Krishna
       HABI, Abdelkrim
       BOUSQUET-GAGNON, Nathalie
 
<120>  PEPTIDE COMPOUNDS DERIVED FROM MELANOTRANSFERRIN AND USES THEREOF

<130>  780/11718.320

<150>  US 61/548,905
<151>  2011-10-19

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Gly Pro Ser Gly Ala Leu Trp Leu Leu Leu Ala Leu Arg Thr 
1               5                   10                  15      


Val Leu Gly Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu 
            20                  25                  30          


Gln His Lys Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile 
        35                  40                  45              


Gln Pro Ser Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val 
    50                  55                  60                  


Gln Leu Ile Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly 
65                  70                  75                  80  


Ala Ile Tyr Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly 
                85                  90                  95      


Glu Val Tyr Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val 
            100                 105                 110         


Val Arg Arg Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys 
        115                 120                 125             


Ser Cys His Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val 
    130                 135                 140                 


Gly Tyr Leu Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val 
145                 150                 155                 160 


Leu Lys Ala Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala 
                165                 170                 175     


Gly Glu Thr Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp 
            180                 185                 190         


Ser Ser Gly Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr 
        195                 200                 205             


Asp Tyr Ser Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val 
    210                 215                 220                 


Ala Phe Val Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr 
225                 230                 235                 240 


Leu Pro Ser Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu 
                245                 250                 255     


Cys Arg Asp Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His 
            260                 265                 270         


Leu Ala Arg Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp 
        275                 280                 285             


Gly Gly Leu Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser 
    290                 295                 300                 


His Glu Gly Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln 
305                 310                 315                 320 


Lys Asp Leu Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala 
                325                 330                 335     


Thr Gln Thr Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met 
            340                 345                 350         


Lys Gly Leu Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp 
        355                 360                 365             


Cys Val Leu Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val 
    370                 375                 380                 


Ala Phe Arg Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala 
385                 390                 395                 400 


Lys Ser Pro Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp 
                405                 410                 415     


Ala Val Thr Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr 
            420                 425                 430         


Gly Leu Val Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser 
        435                 440                 445             


Asn Ser Tyr Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala 
    450                 455                 460                 


Phe Thr Leu Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe 
465                 470                 475                 480 


Gly Ser Pro Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg 
                485                 490                 495     


Gly Phe Ile Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu 
            500                 505                 510         


Phe Phe Asn Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro 
        515                 520                 525             


Ser Ser Leu Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys 
    530                 535                 540                 


Cys Val Gly Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe 
545                 550                 555                 560 


Arg Cys Leu Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr 
                565                 570                 575     


Thr Val Phe Asp Asn Thr Asn Gly His Asn Ser Glu Pro Trp Ala Ala 
            580                 585                 590         


Glu Leu Arg Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn Gly Ala Arg 
        595                 600                 605             


Ala Glu Val Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln Ile Pro Pro 
    610                 615                 620                 


His Ala Val Met Val Arg Pro Asp Thr Asn Ile Phe Thr Val Tyr Gly 
625                 630                 635                 640 


Leu Leu Asp Lys Ala Gln Asp Leu Phe Gly Asp Asp His Asn Lys Asn 
                645                 650                 655     


Gly Phe Lys Met Phe Asp Ser Ser Asn Tyr His Gly Gln Asp Leu Leu 
            660                 665                 670         


Phe Lys Asp Ala Thr Val Arg Ala Val Pro Val Gly Glu Lys Thr Thr 
        675                 680                 685             


Tyr Arg Gly Trp Leu Gly Leu Asp Tyr Val Ala Ala Leu Glu Gly Met 
    690                 695                 700                 


Ser Ser Gln Gln Cys Ser Gly Ala Ala Ala Pro Ala Pro Gly Ala Pro 
705                 710                 715                 720 


Leu Leu Pro Leu Leu Leu Pro Ala Leu Ala Ala Arg Leu Leu Pro Pro 
                725                 730                 735     


Ala Leu 
        


<210>  2
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  2

Phe Arg Cys Leu Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His 
1               5                   10                  15      


<210>  3
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  AMIDATION

<400>  3

Tyr Ser Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val Ala 
1               5                   10                  15      


Phe Val Lys His 
            20  


<210>  4
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  AMIDATION

<400>  4

Tyr Arg Gly Ala Phe Arg Cys Leu Val Glu Asn Ala Gly Asp Val Ala 
1               5                   10                  15      


Phe Val Arg His 
            20  


<210>  5
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  AMIDATION

<400>  5

Phe Arg Cys Leu Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His 
1               5                   10                  15      


Lys Lys Lys 
            


<210>  6
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  6

Phe Arg Cys Leu Val Glu Asn Ala Gly Asp Val Gly Phe Val Arg His 
1               5                   10                  15      


<210>  7
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  7

Phe Arg Cys Leu Val Glu Asn Ala Gly Asp Val Pro Phe Val Arg His 
1               5                   10                  15      


<210>  8
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  AMIDATION

<400>  8

Phe Arg Cys Leu Val Glu Gln Ala Pro Asp Val Lys Phe Val Arg His 
1               5                   10                  15      


Lys Lys Lys 
            


<210>  9
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  AMIDATION

<400>  9

Tyr Ser Gly Ala Phe Arg Met Leu Ala Glu Gly Ala Gly Asp Val Ala 
1               5                   10                  15      


Phe Val Lys His Lys Lys Lys 
            20              


<210>  10
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  AMIDATION

<220>
<221>  MISC_FEATURE
<222>  (21)..(39)
<223>  residues 21 to 39 are C to N-terminal

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  ACETYLATION

<400>  10

Phe Arg Cys Leu Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His 
1               5                   10                  15      


Lys Lys Lys Lys Lys Lys Lys His Arg Val Phe Ala Val Asp Gly Ala 
            20                  25                  30          


Asn Glu Val Leu Cys Arg Phe 
        35                  


<210>  11
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is D-Phe

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is D-Cys

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is D-Leu

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is D-Val

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is D-Glu

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is D-Asn

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is D-Asp

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is D-Val

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa at position 13 is D-Phe

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa at position 14 is D-Val

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa at position 16 is D-His

<220>
<221>  MISC_FEATURE
<222>  (17)..(19)
<223>  Xaa at positions 17 to 19 is D-Lys

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  AMIDATION

<400>  11

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa 
            


<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  12

Phe Arg Cys Leu Val Glu Asn Arg Gly Asp Val Pro Phe Val Arg His 
1               5                   10                  15      


<210>  13
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  AMIDATION

<400>  13

Phe Arg Cys Leu Val Glu Asn Arg Gly Asp Val Pro Phe Val Lys Arg 
1               5                   10                  15      


Glu Arg Phe 
            


<210>  14
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  AMIDATION

<400>  14

Tyr Ser Gly Ala Phe Arg Leu Leu Ala Glu Gly Arg Gly Asp Val Ala 
1               5                   10                  15      


Phe Val Lys His Lys Lys 
            20          


<210>  15
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  AMIDATION

<400>  15

Phe Arg Cys Leu Val Glu Asn Arg Gly Asp Val Pro Phe Val Thr Arg 
1               5                   10                  15      


Ile Arg 
        


<210>  16
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  16

Phe Arg Cys Leu Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His 
1               5                   10                  15      


<210>  17
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  17

Tyr Ser Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val Ala 
1               5                   10                  15      


Phe Val Lys His 
            20  


<210>  18
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  18

Tyr Arg Gly Ala Phe Arg Cys Leu Val Glu Asn Ala Gly Asp Val Ala 
1               5                   10                  15      


Phe Val Arg His 
            20  


<210>  19
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  19

Phe Arg Cys Leu Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His 
1               5                   10                  15      


Lys Lys Lys 
            


<210>  20
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  20

Phe Arg Cys Leu Val Glu Asn Ala Gly Asp Val Gly Phe Val Arg His 
1               5                   10                  15      


<210>  21
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  21

Phe Arg Cys Leu Val Glu Asn Ala Gly Asp Val Pro Phe Val Arg His 
1               5                   10                  15      


<210>  22
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  22

Phe Arg Cys Leu Val Glu Gln Ala Pro Asp Val Lys Phe Val Arg His 
1               5                   10                  15      


Lys Lys Lys 
            


<210>  23
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  23

Tyr Ser Gly Ala Phe Arg Met Leu Ala Glu Gly Ala Gly Asp Val Ala 
1               5                   10                  15      


Phe Val Lys His Lys Lys Lys 
            20              


<210>  24
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (21)..(39)
<223>  Residues 21 to 39 are C to N-terminal

<400>  24

Phe Arg Cys Leu Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His 
1               5                   10                  15      


Lys Lys Lys Lys Lys Lys Lys His Arg Val Phe Ala Val Asp Gly Ala 
            20                  25                  30          


Asn Glu Val Leu Cys Arg Phe 
        35                  


<210>  25
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is D-Phe

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-Cys

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-Leu

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is D-Val

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is D-Glu

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is D-Asn

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is D-Asp

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is D-Val

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is D-Phe

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is D-Val

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is D-His

<220>
<221>  MISC_FEATURE
<222>  (17)..(19)
<223>  Xaa is D-Lys

<400>  25

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa 
            


<210>  26
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  26

Phe Arg Cys Leu Val Glu Asn Arg Gly Asp Val Pro Phe Val Arg His 
1               5                   10                  15      


<210>  27
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  27

Phe Arg Cys Leu Val Glu Asn Arg Gly Asp Val Pro Phe Val Lys Arg 
1               5                   10                  15      


Glu Arg Phe 
            


<210>  28
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  28

Tyr Ser Gly Ala Phe Arg Leu Leu Ala Glu Gly Arg Gly Asp Val Ala 
1               5                   10                  15      


Phe Val Lys His Lys Lys 
            20          


<210>  29
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  29

Phe Arg Cys Leu Val Glu Asn Arg Gly Asp Val Pro Phe Val Thr Arg 
1               5                   10                  15      


Ile Arg 
        


<210>  30
<211>  3963
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (115)..(2331)

<400>  30
cacttaagga gctcgggcca gcgcgagggg gagcagggag gaagcccggc tgctgcggac       60

ctcctcggac ccggacccag ccccagcccg gccccagcca gccccgacgg cgcc atg        117
                                                            Met           
                                                            1             

cgg ggt ccg agc ggg gct ctg tgg ctg ctc ctg gct ctg cgc acc gtg        165
Arg Gly Pro Ser Gly Ala Leu Trp Leu Leu Leu Ala Leu Arg Thr Val           
            5                   10                  15                    

ctc ggt ggc atg gag gtg cgg tgg tgc gcc acc tcg gac cca gag cag        213
Leu Gly Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu Gln           
        20                  25                  30                        

cac aag tgc ggc aac atg agc gag gcc ttc cgg gaa gcg ggc atc cag        261
His Lys Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile Gln           
    35                  40                  45                            

ccc tcc ctc ctc tgc gtc cgg ggc acc tcc gcc gac cac tgc gtc cag        309
Pro Ser Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val Gln           
50                  55                  60                  65            

ctc atc gcg gcc cag gag gct gac gcc atc act ctg gat gga gga gcc        357
Leu Ile Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly Ala           
                70                  75                  80                

atc tat gag gcg gga aag gag cac ggc ctg aag ccg gtg gtg ggc gaa        405
Ile Tyr Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly Glu           
            85                  90                  95                    

gtg tac gat caa gag gtc ggt acc tcc tat tac gcc gtg gct gtg gtc        453
Val Tyr Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val Val           
        100                 105                 110                       

agg agg agc tcc cat gtg acc att gac acc ctg aaa ggc gtg aag tcc        501
Arg Arg Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys Ser           
    115                 120                 125                           

tgc cac acg ggc atc aat cgc aca gtg ggc tgg aac gtg ccc gtg ggc        549
Cys His Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val Gly           
130                 135                 140                 145           

tac ctg gtg gag agc ggc cgc ctc tcg gtg atg ggc tgc gat gta ctc        597
Tyr Leu Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val Leu           
                150                 155                 160               

aaa gct gtc agc gac tat ttt ggg ggc agc tgc gtc ccg ggg gca gga        645
Lys Ala Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala Gly           
            165                 170                 175                   

gag acc agt tac tct gag tcc ctc tgt cgc ctc tgc agg ggt gac agc        693
Glu Thr Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp Ser           
        180                 185                 190                       

tct ggg gaa ggg gtg tgt gac aag agc ccc ctg gag aga tac tac gac        741
Ser Gly Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr Asp           
    195                 200                 205                           

tac agc ggg gcc ttc cgg tgc ctg gcg gaa ggg gca ggg gac gtg gct        789
Tyr Ser Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val Ala           
210                 215                 220                 225           

ttt gtg aag cac agc acg gta ctg gag aac acg gat ggg aag acg ctt        837
Phe Val Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr Leu           
                230                 235                 240               

ccc tcc tgg ggc cag gcc ctg ctg tca cag gac ttc gag ctg ctg tgc        885
Pro Ser Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu Cys           
            245                 250                 255                   

cgg gat ggt agc cgg gcc gat gtc acc gag tgg agg cag tgc cat ctg        933
Arg Asp Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His Leu           
        260                 265                 270                       

gcc cgg gtg cct gct cac gcc gtg gtg gtc cgg gcc gac aca gat ggg        981
Ala Arg Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp Gly           
    275                 280                 285                           

ggc ctc atc ttc cgg ctg ctc aac gaa ggc cag cgt ctg ttc agc cac       1029
Gly Leu Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser His           
290                 295                 300                 305           

gag ggc agc agc ttc cag atg ttc agc tct gag gcc tat ggc cag aag       1077
Glu Gly Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln Lys           
                310                 315                 320               

gat cta ctc ttc aaa gac tct acc tcg gag ctt gtg ccc atc gcc aca       1125
Asp Leu Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala Thr           
            325                 330                 335                   

cag acc tat gag gcg tgg ctg ggc cat gag tac ctg cac gcc atg aag       1173
Gln Thr Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met Lys           
        340                 345                 350                       

ggt ctg ctc tgt gac ccc aac cgg ctg ccc ccc tac ctg cgc tgg tgt       1221
Gly Leu Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp Cys           
    355                 360                 365                           

gtg ctc tcc act ccc gag atc cag aag tgt gga gac atg gcc gtg gcc       1269
Val Leu Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val Ala           
370                 375                 380                 385           

ttc cgc cgg cag cgg ctc aag cca gag atc cag tgc gtg tca gcc aag       1317
Phe Arg Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala Lys           
                390                 395                 400               

tcc ccc caa cac tgc atg gag cgg atc cag gct gag cag gtc gac gct       1365
Ser Pro Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp Ala           
            405                 410                 415                   

gtg acc ctg agt ggc gag gac att tac acg gcg ggg aag acg tac ggc       1413
Val Thr Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr Gly           
        420                 425                 430                       

ctg gtt ccc gca gcc ggg gag cac tat gcc ccg gaa gac agc agc aac       1461
Leu Val Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser Asn           
    435                 440                 445                           

tcg tac tac gtg gtg gcc gtg gtg aga cgg gac agc tcc cac gcc ttc       1509
Ser Tyr Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala Phe           
450                 455                 460                 465           

acc ttg gat gag ctt cgg ggc aag cgc tcc tgc cac gcc ggt ttc ggc       1557
Thr Leu Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe Gly           
                470                 475                 480               

agc cct gca ggc tgg gat gtc ccc gtg ggt gcc ctt att cag aga ggc       1605
Ser Pro Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg Gly           
            485                 490                 495                   

ttc atc cgg ccc aag gac tgt gac gtc ctc aca gca gtg agc gag ttc       1653
Phe Ile Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu Phe           
        500                 505                 510                       

ttc aat gcc agc tgc gtg ccc gtg aac aac ccc aag aac tac ccc tcc       1701
Phe Asn Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser           
    515                 520                 525                           

tcg ctg tgt gca ctg tgc gtg ggg gac gag cag ggc cgc aac aag tgt       1749
Ser Leu Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys Cys           
530                 535                 540                 545           

gtg ggc aac agc cag gag cgg tat tac ggc tac cgc ggc gcc ttc agg       1797
Val Gly Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe Arg           
                550                 555                 560               

tgc ctg gtg gag aat gcg ggt gac gtt gcc ttc gtc agg cac aca acc       1845
Cys Leu Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr Thr           
            565                 570                 575                   

gtc ttt gac aac aca aac ggc cac aat tcc gag ccc tgg gct gct gag       1893
Val Phe Asp Asn Thr Asn Gly His Asn Ser Glu Pro Trp Ala Ala Glu           
        580                 585                 590                       

ctc agg tca gag gac tat gaa ctg ctg tgc ccc aac ggg gcc cga gcc       1941
Leu Arg Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn Gly Ala Arg Ala           
    595                 600                 605                           

gag gtg tcc cag ttt gca gcc tgc aac ctg gca cag ata cca ccc cac       1989
Glu Val Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln Ile Pro Pro His           
610                 615                 620                 625           

gcc gtg atg gtc cgg ccc gac acc aac atc ttc acc gtg tat gga ctg       2037
Ala Val Met Val Arg Pro Asp Thr Asn Ile Phe Thr Val Tyr Gly Leu           
                630                 635                 640               

ctg gac aag gcc cag gac ctg ttt gga gac gac cac aat aag aac ggg       2085
Leu Asp Lys Ala Gln Asp Leu Phe Gly Asp Asp His Asn Lys Asn Gly           
            645                 650                 655                   

ttc aaa atg ttc gac tcc tcc aac tat cat ggc caa gac ctg ctt ttc       2133
Phe Lys Met Phe Asp Ser Ser Asn Tyr His Gly Gln Asp Leu Leu Phe           
        660                 665                 670                       

aag gat gcc acc gtc cgg gcg gtg cct gtc gga gag aaa acc acc tac       2181
Lys Asp Ala Thr Val Arg Ala Val Pro Val Gly Glu Lys Thr Thr Tyr           
    675                 680                 685                           

cgc ggc tgg ctg ggg ctg gac tac gtg gcg gcg ctg gaa ggg atg tcg       2229
Arg Gly Trp Leu Gly Leu Asp Tyr Val Ala Ala Leu Glu Gly Met Ser           
690                 695                 700                 705           

tct cag cag tgc tcg ggc gca gcg gcc ccg gcg ccc ggg gcg ccc ctg       2277
Ser Gln Gln Cys Ser Gly Ala Ala Ala Pro Ala Pro Gly Ala Pro Leu           
                710                 715                 720               

ctc ccg ctg ctg ctg ccc gcc ctc gcc gcc cgc ctg ctc ccg ccc gcc       2325
Leu Pro Leu Leu Leu Pro Ala Leu Ala Ala Arg Leu Leu Pro Pro Ala           
            725                 730                 735                   

ctc tga gcccggccgc cccgccccag agctccgatg cccgcccggg gagtttccgc        2381
Leu                                                                       
                                                                          

ggcggcttcg cgctggaatc cagaaggaag ctcgcgaagg ccgggcccgg cgtgggcggg     2441

agcaggcgcc tccccgggag ccccgccgcc cacgggcgcc acctggcgct gctacctgag     2501

gcgccgcccc cgggcccgcg cggcccttcc cgccaaccgc cgcctcccgc cacctggagc     2561

cgcgcgggcc gcgccggagg aggccggttg cccaggaaac cgctgagtcc gggcttcccg     2621

ccgcccgccc cgcggtgtcg cccgaggggc ccgcccgcct cctccccgca gccccgcgcc     2681

cccgtccgcg aggccccctg gggacgcggt ggccgccgag gcgcctacac ccgcaggccg     2741

cggccaggcc gtcccaggag gccccggcgc caacgggacc cggcgcgtgg gacagcggcc     2801

tctgctggcg gcggcgggag ggaggccgga ccggggcgac ggggagaagc cttcgcccgc     2861

gggaccgtgt ccggggtggg ggctccagtt cctccgaccg cccgtgcgct gggagggagg     2921

ccgagcccgg ggaacgccgc gtgccctgcc tcgtccccca ctgtggccgc gccagctcca     2981

tcccgggcca gccgcgtcca cgggccccct cccgagtctc ctcaggctct cgcctcccct     3041

acccccgtgg gatgcccacc gcccgcaccc acgcccgagc ctggcggcag cagccgcccc     3101

ccgcctgaag ggagccggag gtgacccagg ccgcgggctc ccgaggcccc tgaagggctg     3161

cgcgtgggga cccgccatgc ttctgggttc cgaacggggg tgagctccgt ctcctcaccc     3221

ggccccgcac ccgctgggcc tggggacccc tcactccccg tgcccgcccc tccgcgaggc     3281

agcagaaagc gcccggccgg ggcctctctc tactccatct tgccacagtt gtctgagaag     3341

ccagaaaaag tttccagaac tggcagccct taaaaaaaat gaagaggaag agaagaaatg     3401

ggagcaggca gccctcgtca gcagaccggg agccgcgtgg gcgcggagcc atttgcattc     3461

cggtctgcgg gggctcgggg atgctggtga caggcccggt tcccggtggc tcgcccccac     3521

ctgcgggcgt cgggaaggat cccttccatc tctcagccgc agaggaggcc ctggcagcgc     3581

cccggctgta gccatgcaac cccgaggagt cccgggcacc ttcaccccac cgggaggggc     3641

cacaaggacc tgggcctcgg ccaccaagct ttgtcccctc tcgctgtggg gggctagtga     3701

ttctcctccg acctgacgat tgcttggttt tttcaaaagg gagttttgtg cggtgagaag     3761

tgtgtttctg tgtggctaac tctgggctag cgtgccgtgg ccattgaagg tgtggcctgc     3821

gtgggtgcag tgtaagtgac gctggattgt caggtggcag caggggaccc ctgctgtgtc     3881

agtgctaatg aaacatgttg gttggtttct aaaataaagc caaacaagcc agcacatgca     3941

gaggcttgga ccctgataga aa                                              3963


<210>  31
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Arg Gly Pro Ser Gly Ala Leu Trp Leu Leu Leu Ala Leu Arg Thr 
1               5                   10                  15      


Val Leu Gly Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu 
            20                  25                  30          


Gln His Lys Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile 
        35                  40                  45              


Gln Pro Ser Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val 
    50                  55                  60                  


Gln Leu Ile Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly 
65                  70                  75                  80  


Ala Ile Tyr Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly 
                85                  90                  95      


Glu Val Tyr Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val 
            100                 105                 110         


Val Arg Arg Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys 
        115                 120                 125             


Ser Cys His Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val 
    130                 135                 140                 


Gly Tyr Leu Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val 
145                 150                 155                 160 


Leu Lys Ala Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala 
                165                 170                 175     


Gly Glu Thr Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp 
            180                 185                 190         


Ser Ser Gly Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr 
        195                 200                 205             


Asp Tyr Ser Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val 
    210                 215                 220                 


Ala Phe Val Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr 
225                 230                 235                 240 


Leu Pro Ser Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu 
                245                 250                 255     


Cys Arg Asp Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His 
            260                 265                 270         


Leu Ala Arg Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp 
        275                 280                 285             


Gly Gly Leu Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser 
    290                 295                 300                 


His Glu Gly Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln 
305                 310                 315                 320 


Lys Asp Leu Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala 
                325                 330                 335     


Thr Gln Thr Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met 
            340                 345                 350         


Lys Gly Leu Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp 
        355                 360                 365             


Cys Val Leu Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val 
    370                 375                 380                 


Ala Phe Arg Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala 
385                 390                 395                 400 


Lys Ser Pro Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp 
                405                 410                 415     


Ala Val Thr Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr 
            420                 425                 430         


Gly Leu Val Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser 
        435                 440                 445             


Asn Ser Tyr Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala 
    450                 455                 460                 


Phe Thr Leu Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe 
465                 470                 475                 480 


Gly Ser Pro Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg 
                485                 490                 495     


Gly Phe Ile Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu 
            500                 505                 510         


Phe Phe Asn Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro 
        515                 520                 525             


Ser Ser Leu Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys 
    530                 535                 540                 


Cys Val Gly Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe 
545                 550                 555                 560 


Arg Cys Leu Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr 
                565                 570                 575     


Thr Val Phe Asp Asn Thr Asn Gly His Asn Ser Glu Pro Trp Ala Ala 
            580                 585                 590         


Glu Leu Arg Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn Gly Ala Arg 
        595                 600                 605             


Ala Glu Val Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln Ile Pro Pro 
    610                 615                 620                 


His Ala Val Met Val Arg Pro Asp Thr Asn Ile Phe Thr Val Tyr Gly 
625                 630                 635                 640 


Leu Leu Asp Lys Ala Gln Asp Leu Phe Gly Asp Asp His Asn Lys Asn 
                645                 650                 655     


Gly Phe Lys Met Phe Asp Ser Ser Asn Tyr His Gly Gln Asp Leu Leu 
            660                 665                 670         


Phe Lys Asp Ala Thr Val Arg Ala Val Pro Val Gly Glu Lys Thr Thr 
        675                 680                 685             


Tyr Arg Gly Trp Leu Gly Leu Asp Tyr Val Ala Ala Leu Glu Gly Met 
    690                 695                 700                 


Ser Ser Gln Gln Cys Ser Gly Ala Ala Ala Pro Ala Pro Gly Ala Pro 
705                 710                 715                 720 


Leu Leu Pro Leu Leu Leu Pro Ala Leu Ala Ala Arg Leu Leu Pro Pro 
                725                 730                 735     


Ala Leu 
        


<210>  32
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  32

Arg Trp Cys Ala Thr Ser Asp Pro Glu Gln His Lys Cys Gly Asn Met 
1               5                   10                  15      


Ser Glu Ala Phe Arg Glu Ala Gly Ile Gln Pro Ser Leu Leu Cys Val 
            20                  25                  30          


Arg Gly Thr Ser Ala Asp His Cys Val Gln Leu Ile Ala Ala Gln Glu 
        35                  40                  45              


Ala Asp Ala Ile Thr Leu Asp Gly Gly Ala Ile Tyr Glu Ala Gly Lys 
    50                  55                  60                  


Glu His Gly Leu Lys Pro Val Val Gly Glu Val Tyr Asp Gln Glu Val 
65                  70                  75                  80  


Gly Thr Ser Tyr Tyr Ala Val Ala Val Val Arg Arg Ser Ser His Val 
                85                  90                  95      


Thr Ile Asp Thr Leu Lys Gly Val Lys Ser Cys His Thr Gly Ile Asn 
            100                 105                 110         


Arg Thr Val Gly Trp Asn Val Pro Val Gly Tyr Leu Val Glu Ser Gly 
        115                 120                 125             


Arg Leu Ser Val Met Gly Cys Asp Val Leu Lys Ala Val Ser Asp Tyr 
    130                 135                 140                 


Phe Gly Gly Ser Cys Val Pro Gly Ala Gly Glu Thr Ser Tyr Ser Glu 
145                 150                 155                 160 


Ser Leu Cys Arg Leu Cys Arg Gly Asp Ser Ser Gly Glu Gly Val Cys 
                165                 170                 175     


Asp Lys Ser Pro Leu Glu Arg Tyr Tyr Asp Tyr Ser Gly Ala Phe Arg 
            180                 185                 190         


Cys Leu Ala Glu Gly Ala Gly Asp Val Ala Phe Val Lys His Ser Thr 
        195                 200                 205             


Val Leu Glu Asn Thr Asp Gly Lys Thr Leu Pro Ser Trp Gly Gln Ala 
    210                 215                 220                 


Leu Leu Ser Gln Asp Phe Glu Leu Leu Cys Arg Asp Gly Ser Arg Ala 
225                 230                 235                 240 


Asp Val Thr Glu Trp Arg Gln Cys His Leu Ala Arg Val Pro Ala His 
                245                 250                 255     


Ala Val Val Val Arg Ala Asp Thr Asp Gly Gly Leu Ile Phe Arg Leu 
            260                 265                 270         


Leu Asn Glu Gly Gln Arg Leu Phe Ser His Glu Gly Ser Ser Phe Gln 
        275                 280                 285             


Met Phe Ser Ser Glu Ala Tyr Gly Gln Lys Asp Leu Leu Phe Lys Asp 
    290                 295                 300                 


Ser Thr Ser Glu Leu Val Pro Ile Ala Thr Gln Thr Tyr Glu Ala Trp 
305                 310                 315                 320 


Leu Gly His Glu Tyr Leu His Ala Met Lys Gly Leu 
                325                 330         


<210>  33
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  33

Arg Trp Cys Val Leu Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met 
1               5                   10                  15      


Ala Val Ala Phe Arg Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val 
            20                  25                  30          


Ser Ala Lys Ser Pro Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln 
        35                  40                  45              


Val Asp Ala Val Thr Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys 
    50                  55                  60                  


Thr Tyr Gly Leu Val Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp 
65                  70                  75                  80  


Ser Ser Asn Ser Tyr Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser 
                85                  90                  95      


His Ala Phe Thr Leu Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala 
            100                 105                 110         


Gly Phe Gly Ser Pro Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile 
        115                 120                 125             


Gln Arg Gly Phe Ile Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val 
    130                 135                 140                 


Ser Glu Phe Phe Asn Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn 
145                 150                 155                 160 


Tyr Pro Ser Ser Leu Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg 
                165                 170                 175     


Asn Lys Cys Val Gly Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly 
            180                 185                 190         


Ala Phe Arg Cys Leu Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg 
        195                 200                 205             


His Thr Thr Val Phe Asp Asn Thr Asn Gly His Asn Ser Glu Pro Trp 
    210                 215                 220                 


Ala Ala Glu Leu Arg Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn Gly 
225                 230                 235                 240 


Ala Arg Ala Glu Val Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln Ile 
                245                 250                 255     


Pro Pro His Ala Val Met Val Arg Pro Asp Thr Asn Ile Phe Thr Val 
            260                 265                 270         


Tyr Gly Leu Leu Asp Lys Ala Gln Asp Leu Phe Gly Asp Asp His Asn 
        275                 280                 285             


Lys Asn Gly Phe Lys Met Phe Asp Ser Ser Asn Tyr His Gly Gln Asp 
    290                 295                 300                 


Leu Leu Phe Lys Asp Ala Thr Val Arg Ala Val Pro Val Gly Glu Lys 
305                 310                 315                 320 


Thr Thr Tyr Arg Gly Trp Leu Gly Leu Asp Tyr Val Ala Ala Leu Glu 
                325                 330                 335     


Gly Met 
        


