                             SEQUENCE LISTING

<110>  University Health Network
       The Hospital for Sick Children
 
<120>  ANTIBODIES AND ANTIBODY FRAGMENTS TARGETING SIRPa AND THEIR USE 
       IN TREATING HEMATOLOGIC CANCERS

<130>  05014971-45PCT

<150>  US 61/548,817
<151>  2011-10-19

<160>  141   

<170>  PatentIn version 3.5

<210>  1
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Ser Glu Phe Glu Glu 
1               5                   10                  15      


Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala Ala Gly 
            20                  25                  30          


Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val Gly 
        35                  40                  45              


Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr 
    50                  55                  60                  


Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu 
65                  70                  75                  80  


Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn Ile Thr 
                85                  90                  95      


Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 
            100                 105                 110         


Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val 
        115                 120                 125             


Arg Gly Ser His His His His His His His His His His 
    130                 135                 140     


<210>  2
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  2

Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Ser Glu Phe Glu Glu 
1               5                   10                  15      


Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala Ala Gly 
            20                  25                  30          


Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro Val Gly 
        35                  40                  45              


Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu Ile Tyr 
    50                  55                  60                  


Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Glu Ser 
65                  70                  75                  80  


Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn Ile Thr 
                85                  90                  95      


Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 
            100                 105                 110         


Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val Arg 
        115                 120                 125             


Gly Ser His His His His His His His His His His 
    130                 135                 140 


<210>  3
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  3

Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Ser Glu Phe Glu Asp 
1               5                   10                  15      


Glu Leu Gln Val Ile Gln Pro Glu Lys Ser Val Ser Val Ala Ala Gly 
            20                  25                  30          


Glu Ser Ala Thr Leu Arg Cys Ala Met Thr Ser Leu Ile Pro Val Gly 
        35                  40                  45              


Pro Ile Met Trp Phe Arg Gly Ala Gly Ala Gly Arg Glu Leu Ile Tyr 
    50                  55                  60                  


Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Glu Leu 
65                  70                  75                  80  


Thr Lys Arg Asn Asn Leu Asp Phe Ser Ile Ser Ile Ser Asn Ile Thr 
                85                  90                  95      


Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 
            100                 105                 110         


Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val 
        115                 120                 125             


Arg Gly Ser His His His His His His His His His His 
    130                 135                 140     


<210>  4
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Ser Glu Phe Glu Glu 
1               5                   10                  15      


Glu Leu Gln Met Ile Gln Pro Glu Lys Leu Leu Leu Val Thr Val Gly 
            20                  25                  30          


Lys Thr Ala Thr Leu His Cys Thr Val Thr Ser Leu Leu Pro Val Gly 
        35                  40                  45              


Pro Val Leu Trp Phe Arg Gly Val Gly Pro Gly Arg Glu Leu Ile Tyr 
    50                  55                  60                  


Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu 
65                  70                  75                  80  


Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Ser Ser Ile Thr 
                85                  90                  95      


Pro Ala Asp Val Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 
            100                 105                 110         


Pro Glu Asn Val Glu Phe Lys Ser Gly Pro Gly Thr Glu Met Ala Leu 
        115                 120                 125             


Gly Gly Ser His His His His His His His His His His 
    130                 135                 140     


<210>  5
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  5
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gtccgtgtcc agcgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactcg gcatccagcc tctactctgg agtcccttct      180

cgcttctctg gtagccgttc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa gccgttaact gggttggtgc actcgttacg      300

ttcggacagg gtaccaaggt ggagatcaaa cgtacg                                336


<210>  6
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Val Asn Trp Val Gly 
                85                  90                  95      


Ala Leu Val Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


<210>  7
<211>  393
<212>  DNA
<213>  Homo sapiens

<400>  7
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacatctcc tactacttca ttcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatcc gtttactcct ccttcggtta cacctactat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgctttact      300

tttcctggtc tttttactgg tttttttggt gcttatcttg gtagtcttga ctactggggt      360

caaggaaccc tggtcaccgt ctcctcggct agc                                   393


<210>  8
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Ser Tyr Tyr 
            20                  25                  30          


Phe Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Tyr Ser Ser Phe Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Thr Phe Pro Gly Leu Phe Thr Gly Phe Phe Gly Ala Tyr 
            100                 105                 110         


Leu Gly Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser 
    130     


<210>  9
<211>  393
<212>  DNA
<213>  Homo sapiens

<400>  9
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacatctcc tactacttca ttcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatcc gtttactcct ccttcggtta cacctactat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgctttact      300

tttcctggtg cgatggatgg tttttttggt gcttatcttg gtagtcttga ctactggggt      360

caaggaaccc tggtcaccgt ctcctcggct agc                                   393


<210>  10
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Ser Tyr Tyr 
            20                  25                  30          


Phe Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Tyr Ser Ser Phe Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Thr Phe Pro Gly Ala Met Asp Gly Phe Phe Gly Ala Tyr 
            100                 105                 110         


Leu Gly Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser 
    130     


<210>  11
<211>  393
<212>  DNA
<213>  Homo sapiens

<400>  11
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacatctcc tactacttca ttcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatcc gtttactcct ccttcggtta cacctactat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgctttact      300

tttcctggtc tgtttgatgg gttttttggt gcttatcttg gtagtcttga ctactggggt      360

caaggaaccc tggtcaccgt ctcctcggct agc                                   393


<210>  12
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Ser Tyr Tyr 
            20                  25                  30          


Phe Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Tyr Ser Ser Phe Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Thr Phe Pro Gly Leu Phe Asp Gly Phe Phe Gly Ala Tyr 
            100                 105                 110         


Leu Gly Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser 
    130     


<210>  13
<211>  393
<212>  DNA
<213>  Homo sapiens

<400>  13
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacatctcc tactacttca ttcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatcc gtttactcct ccttcggtta cacctactat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgcttttct      300

tttccggggc tatttgatgg gttttttcga tcttatctgg ggagtcttga ctactggggt      360

caaggaaccc tggtcaccgt ctcctcggct agc                                   393


<210>  14
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Ser Tyr Tyr 
            20                  25                  30          


Phe Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Tyr Ser Ser Phe Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ser Phe Pro Gly Leu Phe Asp Gly Phe Phe Arg Ser Tyr 
            100                 105                 110         


Leu Gly Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser 
    130     


<210>  15
<211>  393
<212>  DNA
<213>  Homo sapiens

<400>  15
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacatctcc tactacttca ttcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatcc gtttactcct ccttcggtta cacctactat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgctttgct      300

tttcctggtc tgtttgatgg gttttttcgt aattatcttg gcagtcttga ctactggggt      360

caaggaaccc tggtcaccgt ctcctcggct agc                                   393


<210>  16
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Ser Tyr Tyr 
            20                  25                  30          


Phe Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Tyr Ser Ser Phe Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Phe Pro Gly Leu Phe Asp Gly Phe Phe Arg Asn Tyr 
            100                 105                 110         


Leu Gly Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser 
    130     


<210>  17
<211>  393
<212>  DNA
<213>  Homo sapiens

<400>  17
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacatctcc tactacttca ttcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatcc gtttactcct ccttcggtta cacctactat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgcttcgct      300

tttcctggac tttttaatgg gttttttaga gcttatctgg gtagtcttga ctactggggt      360

caaggaaccc tggtcaccgt ctcctcggct agc                                   393


<210>  18
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Ser Tyr Tyr 
            20                  25                  30          


Phe Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Tyr Ser Ser Phe Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Phe Pro Gly Leu Phe Asn Gly Phe Phe Arg Ala Tyr 
            100                 105                 110         


Leu Gly Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser 
    130     


<210>  19
<211>  393
<212>  DNA
<213>  Homo sapiens

<400>  19
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacatctcc tactacttca ttcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatcc gtttactcct ccttcggtta cacctactat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgctttact      300

tttcctggtc tgtttgatgg gttttttagg gattatttag gaagtattga ctactggggt      360

caaggaaccc tggtcaccgt ctcctcggct agc                                   393


<210>  20
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Ser Tyr Tyr 
            20                  25                  30          


Phe Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Tyr Ser Ser Phe Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Thr Phe Pro Gly Leu Phe Asp Gly Phe Phe Arg Asp Tyr 
            100                 105                 110         


Leu Gly Ser Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser 
    130     


<210>  21
<211>  393
<212>  DNA
<213>  Homo sapiens

<400>  21
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacatctcc tactacttca ttcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatcc gtttactcct ccttcggtta cacctactat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgctttgcc      300

tttcctggtt tgtttgatgg tttttttcgt gattatcttg gtagtattga ctactggggt      360

caaggaaccc tggtcaccgt ctcctcggct agc                                   393


<210>  22
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Ser Tyr Tyr 
            20                  25                  30          


Phe Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Tyr Ser Ser Phe Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Phe Pro Gly Leu Phe Asp Gly Phe Phe Arg Asp Tyr 
            100                 105                 110         


Leu Gly Ser Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser 
    130     


<210>  23
<211>  393
<212>  DNA
<213>  Homo sapiens

<400>  23
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacatctcc tactacttca ttcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatcc gtttactcct ccttcggtta cacctactat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgctttgct      300

tttcctggtc tgtttgatgg gttttttcgt gcgtatcttg gtagtcttga ctactggggt      360

caaggaaccc tggtcaccgt ctcctcggct agc                                   393


<210>  24
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Ser Tyr Tyr 
            20                  25                  30          


Phe Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Tyr Ser Ser Phe Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Phe Pro Gly Leu Phe Asp Gly Phe Phe Arg Ala Tyr 
            100                 105                 110         


Leu Gly Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser 
    130     


<210>  25
<211>  393
<212>  DNA
<213>  Homo sapiens

<400>  25
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacatctcc tactacttca ttcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatcc gtttactcct ccttcggtta cacctactat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgctttgct      300

tttcctggat tgttcgatgg tttttttggt ccttatctcg gccctctaga ctactggggt      360

caaggaaccc tggtcaccgt ctcctcggct agc                                   393


<210>  26
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Ser Tyr Tyr 
            20                  25                  30          


Phe Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Tyr Ser Ser Phe Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Phe Pro Gly Leu Phe Asp Gly Phe Phe Gly Pro Tyr 
            100                 105                 110         


Leu Gly Pro Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser 
    130     


<210>  27
<211>  4184
<212>  DNA
<213>  Homo sapiens

<400>  27
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacctgaga tcaacatgta caggatgcaa ctcctgtctt gcattgcact aagtcttgca      600

cttgtcacga attcggatat ccagatgacc cagtccccga gctccctgtc cgcctctgtg      660

ggcgataggg tcaccatcac ctgccgtgcc agtcagtccg tgtccagcgc tgtagcctgg      720

tatcaacaga aaccaggaaa agctccgaag cttctgattt actcggcatc cagcctctac      780

tctggagtcc cttctcgctt ctctggtagc cgttccggga cggatttcac tctgaccatc      840

agcagtctgc agccggaaga cttcgcaact tattactgtc agcaagccgt taactgggtt      900

ggtgcactcg ttacgttcgg acagggtacc aaggtggaga tcaaacgtac ggtggctgca      960

ccatctgtct tcatcttccc gccatctgat gagcagttga aatctggaac tgcctctgtt     1020

gtgtgcctgc tgaataactt ctatcccaga gaggccaaag tacagtggaa ggtggataac     1080

gccctccaat cgggtaactc ccaggagagt gtcacagagc aggacagcaa ggacagcacc     1140

tacagcctca gcagcaccct gacgctgagc aaagcagact acgagaaaca caaagtctac     1200

gcctgcgaag tcacccatca gggcctgagc tcgcccgtca caaagagctt caacagggga     1260

gagtgttaga gggagctagc tcgacatgat aagatacatt gatgagtttg gacaaaccac     1320

aactagaatg cagtgaaaaa aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt     1380

tgtgaaattt gtgatgctat tgctttattt gtaaccatta taagctgcaa taaacaagtt     1440

aacaacaaca attgcattca ttttatgttt caggttcagg gggaggtgtg ggaggttttt     1500

taaagcaagt aaaacctcta caaatgtggt atggaattaa ttctaaaata cagcatagca     1560

aaactttaac ctccaaatca agcctctact tgaatccttt tctgagggat gaataaggca     1620

taggcatcag gggctgttgc caatgtgcat tagctgtttg cagcctcacc ttctttcatg     1680

gagtttaaga tatagtgtat tttcccaagg tttgaactag ctcttcattt ctttatgttt     1740

taaatgcact gacctcccac attccctttt tagtaaaata ttcagaaata atttaaatac     1800

atcattgcaa tgaaaataaa tgttttttat taggcagaat ccagatgctc aaggcccttc     1860

ataatatccc ccagtttagt agttggactt agggaacaaa ggaaccttta atagaaattg     1920

gacagcaaga aagcgagctt ctagctttag ttcctggtgt acttgagggg gatgagttcc     1980

tcaatggtgg ttttgaccag cttgccattc atctcaatga gcacaaagca gtcaggagca     2040

tagtcagaga tgagctctct gcacatgcca caggggctga ccaccctgat ggatctgtcc     2100

acctcatcag agtaggggtg cctgacagcc acaatggtgt caaagtcctt ctgcccgttg     2160

ctcacagcag acccaatggc aatggcttca gcacagacag tgaccctgcc aatgtaggcc     2220

tcaatgtgga cagcagagat gatctcccca gtcttggtcc tgatggccgc cccgacatgg     2280

tgcttgttgt cctcatagag catggtgatc ttctcagtgg cgacctccac cagctccaga     2340

tcctgctgag agatgttgaa ggtcttcatg atggctcctc ctgtcaggag aggaaagaga     2400

agaaggttag tacaattgct atagtgagtt gtattatact atgcttatga ttaattgtca     2460

aactagggct gcagggttca tagtgccact tttcctgcac tgccccatct cctgcccacc     2520

ctttcccagg catagacagt cagtgactta ccaaactcac aggagggaga aggcagaagc     2580

ttgagacaga cccgcgggac cgccgaactg cgaggggacg tggctagggc ggcttctttt     2640

atggtgcgcc ggccctcgga ggcagggcgc tcggggaggc ctagcggcca atctgcggtg     2700

gcaggaggcg gggccgaagg ccgtgcctga ccaatccgga gcacatagga gtctcagccc     2760

cccgccccaa agcaagggga agtcacgcgc ctgtagcgcc agcgtgttgt gaaatggggg     2820

cttggggggg ttggggccct gactagtcaa aacaaactcc cattgacgtc aatggggtgg     2880

agacttggaa atccccgtga gtcaaaccgc tatccacgcc cattgatgta ctgccaaaac     2940

cgcatcatca tggtaatagc gatgactaat acgtagatgt actgccaagt aggaaagtcc     3000

cataaggtca tgtactgggc ataatgccag gcgggccatt taccgtcatt gacgtcaata     3060

gggggcgtac ttggcatatg atacacttga tgtactgcca agtgggcagt ttaccgtaaa     3120

tactccaccc attgacgtca atggaaagtc cctattggcg ttactatggg aacatacgtc     3180

attattgacg tcaatgggcg ggggtcgttg ggcggtcagc caggcgggcc atttaccgta     3240

agttatgtaa cgcctgcagg ttaattaaga acatgtgagc aaaaggccag caaaaggcca     3300

ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag gctccgcccc cctgacgagc     3360

atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta taaagatacc     3420

aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg     3480

gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta     3540

ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg     3600

ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac ccggtaagac     3660

acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg aggtatgtag     3720

gcggtgctac agagttcttg aagtggtggc ctaactacgg ctacactaga agaacagtat     3780

ttggtatctg cgctctgctg aagccagtta ccttcggaaa aagagttggt agctcttgat     3840

ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag cagattacgc     3900

gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct gacgctcagt     3960

ggaacgaaaa ctcacgttaa gggattttgg tcatggctag ttaattaaca tttaaatcag     4020

cggccgcaat aaaatatctt tattttcatt acatctgtgt gttggttttt tgtgtgaatc     4080

gtaactaaca tacgctctcc atcaaaacaa aacgaaacaa aacaaactag caaaataggc     4140

tgtccccagt gcaagtgcag gtgccagaac atttctctat cgaa                      4184


<210>  28
<211>  4860
<212>  DNA
<213>  Homo sapiens

<400>  28
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacctgaga tcaccggcga aggagggcca ccatgtacag gatgcaactc ctgtcttgca      600

ttgcactaag tcttgcactt gtcacgaatt cggaggttca gctggtggag tctggcggtg      660

gcctggtgca gccagggggc tcactccgtt tgtcctgtgc agcttctggc ttcaacatct      720

cctactactt cattcactgg gtgcgtcagg ccccgggtaa gggcctggaa tgggttgcat      780

ccgtttactc ctccttcggt tacacctact atgccgatag cgtcaagggc cgtttcacta      840

taagcgcaga cacatccaaa aacacagcct acctacaaat gaacagctta agagctgagg      900

acactgccgt ctattattgt gctcgcttta cttttcctgg tctttttact ggtttttttg      960

gtgcttatct tggtagtctt gactactggg gtcaaggaac cctggtcacc gtctcctcgg     1020

ctagcaccaa gggcccatcg gtcttccccc tggcgccctg ctccaggagc acctccgaga     1080

gcacagccgc cctgggctgc ctggtcaagg actacttccc cgaaccggtg acggtgtcgt     1140

ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta cagtcctcag     1200

gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc acgaagacct     1260

acacctgcaa cgtagatcac aagcccagca acaccaaggt ggacaagaga gttgagtcca     1320

aatatggtcc cccatgccca tcatgcccag cacctgagtt cctgggggga ccatcagtct     1380

tcctgttccc cccaaaaccc aaggacactc tcatgatctc ccggacccct gaggtcacgt     1440

gcgtggtggt ggacgtgagc caggaagacc ccgaggtcca gttcaactgg tacgtggatg     1500

gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagttcaac agcacgtacc     1560

gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaacggcaag gagtacaagt     1620

gcaaggtctc caacaaaggc ctcccgtcct ccatcgagaa aaccatctcc aaagccaaag     1680

ggcagccccg agagccacag gtgtacaccc tgcccccatc ccaggaggag atgaccaaga     1740

accaggtcag cctgacctgc ctggtcaaag gcttctaccc cagcgacatc gccgtggagt     1800

gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg ctggactccg     1860

acggctcctt cttcctctac agcaggctca ccgtggacaa gagcaggtgg caggagggga     1920

atgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacaca cagaagagcc     1980

tctccctgtc tccgggtaaa tgagtcctag ctggccagac atgataagat acattgatga     2040

gtttggacaa accacaacta gaatgcagtg aaaaaaatgc tttatttgtg aaatttgtga     2100

tgctattgct ttatttgtaa ccattataag ctgcaataaa caagttaaca acaacaattg     2160

cattcatttt atgtttcagg ttcaggggga ggtgtgggag gttttttaaa gcaagtaaaa     2220

cctctacaaa tgtggtatgg aattaattct aaaatacagc atagcaaaac tttaacctcc     2280

aaatcaagcc tctacttgaa tccttttctg agggatgaat aaggcatagg catcaggggc     2340

tgttgccaat gtgcattagc tgtttgcagc ctcaccttct ttcatggagt ttaagatata     2400

gtgtattttc ccaaggtttg aactagctct tcatttcttt atgttttaaa tgcactgacc     2460

tcccacattc cctttttagt aaaatattca gaaataattt aaatacatca ttgcaatgaa     2520

aataaatgtt ttttattagg cagaatccag atgctcaagg cccttcataa tatcccccag     2580

tttagtagtt ggacttaggg aacaaaggaa cctttaatag aaattggaca gcaagaaagc     2640

gagcttctag cttatcctca gtcctgctcc tctgccacaa agtgcacgca gttgccggcc     2700

gggtcgcgca gggcgaactc ccgcccccac ggctgctcgc cgatctcggt catggccggc     2760

ccggaggcgt cccggaagtt cgtggacacg acctccgacc actcggcgta cagctcgtcc     2820

aggccgcgca cccacaccca ggccagggtg ttgtccggca ccacctggtc ctggaccgcg     2880

ctgatgaaca gggtcacgtc gtcccggacc acaccggcga agtcgtcctc cacgaagtcc     2940

cgggagaacc cgagccggtc ggtccagaac tcgaccgctc cggcgacgtc gcgcgcggtg     3000

agcaccggaa cggcactggt caacttggcc atgatggctc ctcctgtcag gagaggaaag     3060

agaagaaggt tagtacaatt gctatagtga gttgtattat actatgcaga tatactatgc     3120

caatgattaa ttgtcaaact agggctgcag ggttcatagt gccacttttc ctgcactgcc     3180

ccatctcctg cccacccttt cccaggcata gacagtcagt gacttaccaa actcacagga     3240

gggagaaggc agaagcttga gacagacccg cgggaccgcc gaactgcgag gggacgtggc     3300

tagggcggct tcttttatgg tgcgccggcc ctcggaggca gggcgctcgg ggaggcctag     3360

cggccaatct gcggtggcag gaggcggggc cgaaggccgt gcctgaccaa tccggagcac     3420

ataggagtct cagccccccg ccccaaagca aggggaagtc acgcgcctgt agcgccagcg     3480

tgttgtgaaa tgggggcttg ggggggttgg ggccctgact agtcaaaaca aactcccatt     3540

gacgtcaatg gggtggagac ttggaaatcc ccgtgagtca aaccgctatc cacgcccatt     3600

gatgtactgc caaaaccgca tcatcatggt aatagcgatg actaatacgt agatgtactg     3660

ccaagtagga aagtcccata aggtcatgta ctgggcataa tgccaggcgg gccatttacc     3720

gtcattgacg tcaatagggg gcgtacttgg catatgatac acttgatgta ctgccaagtg     3780

ggcagtttac cgtaaatact ccacccattg acgtcaatgg aaagtcccta ttggcgttac     3840

tatgggaaca tacgtcatta ttgacgtcaa tgggcggggg tcgttgggcg gtcagccagg     3900

cgggccattt accgtaagtt atgtaacgcc tgcaggttaa ttaagaacat gtgagcaaaa     3960

ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc     4020

cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg aaacccgaca     4080

ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc tcctgttccg     4140

accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt ggcgctttct     4200

catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt     4260

gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag     4320

tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa caggattagc     4380

agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa ctacggctac     4440

actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt cggaaaaaga     4500

gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt ttttgtttgc     4560

aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctacg     4620

gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat ggctagttaa     4680

ttaacattta aatcagcggc cgcaataaaa tatctttatt ttcattacat ctgtgtgttg     4740

gttttttgtg tgaatcgtaa ctaacatacg ctctccatca aaacaaaacg aaacaaaaca     4800

aactagcaaa ataggctgtc cccagtgcaa gtgcaggtgc cagaacattt ctctatcgaa     4860


<210>  29
<211>  4860
<212>  DNA
<213>  Homo sapiens

<400>  29
tttaaatgca ctgacctccc acattccctt tttagtaaaa tattcagaaa taatttaaat       60

acatcattgc aatgaaaata aatgtttttt attaggcaga atccagatgc tcaaggccct      120

tcataatatc ccccagttta gtagttggac ttagggaaca aaggaacctt taatagaaat      180

tggacagcaa gaaagcgagc ttctagctta tcctcagtcc tgctcctctg ccacaaagtg      240

cacgcagttg ccggccgggt cgcgcagggc gaactcccgc ccccacggct gctcgccgat      300

ctcggtcatg gccggcccgg aggcgtcccg gaagttcgtg gacacgacct ccgaccactc      360

ggcgtacagc tcgtccaggc cgcgcaccca cacccaggcc agggtgttgt ccggcaccac      420

ctggtcctgg accgcgctga tgaacagggt cacgtcgtcc cggaccacac cggcgaagtc      480

gtcctccacg aagtcccggg agaacccgag ccggtcggtc cagaactcga ccgctccggc      540

gacgtcgcgc gcggtgagca ccggaacggc actggtcaac ttggccatga tggctcctcc      600

tgtcaggaga ggaaagagaa gaaggttagt acaattgcta tagtgagttg tattatacta      660

tgcagatata ctatgccaat gattaattgt caaactaggg ctgcagggtt catagtgcca      720

cttttcctgc actgccccat ctcctgccca ccctttccca ggcatagaca gtcagtgact      780

taccaaactc acaggaggga gaaggcagaa gcttgagaca gacccgcggg accgccgaac      840

tgcgagggga cgtggctagg gcggcttctt ttatggtgcg ccggccctcg gaggcagggc      900

gctcggggag gcctagcggc caatctgcgg tggcaggagg cggggccgaa ggccgtgcct      960

gaccaatccg gagcacatag gagtctcagc cccccgcccc aaagcaaggg gaagtcacgc     1020

gcctgtagcg ccagcgtgtt gtgaaatggg ggcttggggg ggttggggcc ctgactagtc     1080

aaaacaaact cccattgacg tcaatggggt ggagacttgg aaatccccgt gagtcaaacc     1140

gctatccacg cccattgatg tactgccaaa accgcatcat catggtaata gcgatgacta     1200

atacgtagat gtactgccaa gtaggaaagt cccataaggt catgtactgg gcataatgcc     1260

aggcgggcca tttaccgtca ttgacgtcaa tagggggcgt acttggcata tgatacactt     1320

gatgtactgc caagtgggca gtttaccgta aatactccac ccattgacgt caatggaaag     1380

tccctattgg cgttactatg ggaacatacg tcattattga cgtcaatggg cgggggtcgt     1440

tgggcggtca gccaggcggg ccatttaccg taagttatgt aacgcctgca ggttaattaa     1500

gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc     1560

gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag     1620

gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt     1680

gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg     1740

aagcgtggcg ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg     1800

ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg     1860

taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac     1920

tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg     1980

gcctaactac ggctacacta gaagaacagt atttggtatc tgcgctctgc tgaagccagt     2040

taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg     2100

tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc     2160

tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt     2220

ggtcatggct agttaattaa catttaaatc agcggccgca ataaaatatc tttattttca     2280

ttacatctgt gtgttggttt tttgtgtgaa tcgtaactaa catacgctct ccatcaaaac     2340

aaaacgaaac aaaacaaact agcaaaatag gctgtcccca gtgcaagtgc aggtgccaga     2400

acatttctct atcgaaggat ctgcgatcgc tccggtgccc gtcagtgggc agagcgcaca     2460

tcgcccacag tccccgagaa gttgggggga ggggtcggca attgaacggg tgcctagaga     2520

aggtggcgcg gggtaaactg ggaaagtgat gtcgtgtact ggctccgcct ttttcccgag     2580

ggtgggggag aaccgtatat aagtgcagta gtcgccgtga acgttctttt tcgcaacggg     2640

tttgccgcca gaacacagct gaagcttcga ggggctcgca tctctccttc acgcgcccgc     2700

cgccctacct gaggccgcca tccacgccgg ttgagtcgcg ttctgccgcc tcccgcctgt     2760

ggtgcctcct gaactgcgtc cgccgtctag gtaagtttaa agctcaggtc gagaccgggc     2820

ctttgtccgg cgctcccttg gagcctacct agactcagcc ggctctccac gctttgcctg     2880

accctgcttg ctcaactcta cgtctttgtt tcgttttctg ttctgcgccg ttacagatcc     2940

aagctgtgac cggcgcctac ctgagatcac cggcgaagga gggccaccat gtacaggatg     3000

caactcctgt cttgcattgc actaagtctt gcacttgtca cgaattcgga ggttcagctg     3060

gtggagtctg gcggtggcct ggtgcagcca gggggctcac tccgtttgtc ctgtgcagct     3120

tctggcttca acatctccta ctacttcatt cactgggtgc gtcaggcccc gggtaagggc     3180

ctggaatggg ttgcatccgt ttactcctcc ttcggttaca cctactatgc cgatagcgtc     3240

aagggccgtt tcactataag cgcagacaca tccaaaaaca cagcctacct acaaatgaac     3300

agcttaagag ctgaggacac tgccgtctat tattgtgctc gctttacttt tcctggtgcg     3360

atggatggtt tttttggtgc ttatcttggt agtcttgact actggggtca aggaaccctg     3420

gtcaccgtct cctcggctag caccaagggc ccatcggtct tccccctggc gccctgctcc     3480

aggagcacct ccgagagcac agccgccctg ggctgcctgg tcaaggacta cttccccgaa     3540

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct     3600

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc     3660

ttgggcacga agacctacac ctgcaacgta gatcacaagc ccagcaacac caaggtggac     3720

aagagagttg agtccaaata tggtccccca tgcccatcat gcccagcacc tgagttcctg     3780

gggggaccat cagtcttcct gttcccccca aaacccaagg acactctcat gatctcccgg     3840

acccctgagg tcacgtgcgt ggtggtggac gtgagccagg aagaccccga ggtccagttc     3900

aactggtacg tggatggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     3960

ttcaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaac     4020

ggcaaggagt acaagtgcaa ggtctccaac aaaggcctcc cgtcctccat cgagaaaacc     4080

atctccaaag ccaaagggca gccccgagag ccacaggtgt acaccctgcc cccatcccag     4140

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctaccccagc     4200

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     4260

cccgtgctgg actccgacgg ctccttcttc ctctacagca ggctcaccgt ggacaagagc     4320

aggtggcagg aggggaatgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     4380

tacacacaga agagcctctc cctgtctccg ggtaaatgag tcctagctgg ccagacatga     4440

taagatacat tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta     4500

tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag     4560

ttaacaacaa caattgcatt cattttatgt ttcaggttca gggggaggtg tgggaggttt     4620

tttaaagcaa gtaaaacctc tacaaatgtg gtatggaatt aattctaaaa tacagcatag     4680

caaaacttta acctccaaat caagcctcta cttgaatcct tttctgaggg atgaataagg     4740

cataggcatc aggggctgtt gccaatgtgc attagctgtt tgcagcctca ccttctttca     4800

tggagtttaa gatatagtgt attttcccaa ggtttgaact agctcttcat ttctttatgt     4860


<210>  30
<211>  4860
<212>  DNA
<213>  Homo sapiens

<400>  30
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacctgaga tcaccggcga aggagggcca ccatgtacag gatgcaactc ctgtcttgca      600

ttgcactaag tcttgcactt gtcacgaatt cggaggttca gctggtggag tctggcggtg      660

gcctggtgca gccagggggc tcactccgtt tgtcctgtgc agcttctggc ttcaacatct      720

cctactactt cattcactgg gtgcgtcagg ccccgggtaa gggcctggaa tgggttgcat      780

ccgtttactc ctccttcggt tacacctact atgccgatag cgtcaagggc cgtttcacta      840

taagcgcaga cacatccaaa aacacagcct acctacaaat gaacagctta agagctgagg      900

acactgccgt ctattattgt gctcgcttta cttttcctgg tctgtttgat gggttttttg      960

gtgcttatct tggtagtctt gactactggg gtcaaggaac cctggtcacc gtctcctcgg     1020

ctagcaccaa gggcccatcg gtcttccccc tggcgccctg ctccaggagc acctccgaga     1080

gcacagccgc cctgggctgc ctggtcaagg actacttccc cgaaccggtg acggtgtcgt     1140

ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta cagtcctcag     1200

gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc acgaagacct     1260

acacctgcaa cgtagatcac aagcccagca acaccaaggt ggacaagaga gttgagtcca     1320

aatatggtcc cccatgccca tcatgcccag cacctgagtt cctgggggga ccatcagtct     1380

tcctgttccc cccaaaaccc aaggacactc tcatgatctc ccggacccct gaggtcacgt     1440

gcgtggtggt ggacgtgagc caggaagacc ccgaggtcca gttcaactgg tacgtggatg     1500

gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagttcaac agcacgtacc     1560

gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaacggcaag gagtacaagt     1620

gcaaggtctc caacaaaggc ctcccgtcct ccatcgagaa aaccatctcc aaagccaaag     1680

ggcagccccg agagccacag gtgtacaccc tgcccccatc ccaggaggag atgaccaaga     1740

accaggtcag cctgacctgc ctggtcaaag gcttctaccc cagcgacatc gccgtggagt     1800

gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg ctggactccg     1860

acggctcctt cttcctctac agcaggctca ccgtggacaa gagcaggtgg caggagggga     1920

atgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacaca cagaagagcc     1980

tctccctgtc tccgggtaaa tgagtcctag ctggccagac atgataagat acattgatga     2040

gtttggacaa accacaacta gaatgcagtg aaaaaaatgc tttatttgtg aaatttgtga     2100

tgctattgct ttatttgtaa ccattataag ctgcaataaa caagttaaca acaacaattg     2160

cattcatttt atgtttcagg ttcaggggga ggtgtgggag gttttttaaa gcaagtaaaa     2220

cctctacaaa tgtggtatgg aattaattct aaaatacagc atagcaaaac tttaacctcc     2280

aaatcaagcc tctacttgaa tccttttctg agggatgaat aaggcatagg catcaggggc     2340

tgttgccaat gtgcattagc tgtttgcagc ctcaccttct ttcatggagt ttaagatata     2400

gtgtattttc ccaaggtttg aactagctct tcatttcttt atgttttaaa tgcactgacc     2460

tcccacattc cctttttagt aaaatattca gaaataattt aaatacatca ttgcaatgaa     2520

aataaatgtt ttttattagg cagaatccag atgctcaagg cccttcataa tatcccccag     2580

tttagtagtt ggacttaggg aacaaaggaa cctttaatag aaattggaca gcaagaaagc     2640

gagcttctag cttatcctca gtcctgctcc tctgccacaa agtgcacgca gttgccggcc     2700

gggtcgcgca gggcgaactc ccgcccccac ggctgctcgc cgatctcggt catggccggc     2760

ccggaggcgt cccggaagtt cgtggacacg acctccgacc actcggcgta cagctcgtcc     2820

aggccgcgca cccacaccca ggccagggtg ttgtccggca ccacctggtc ctggaccgcg     2880

ctgatgaaca gggtcacgtc gtcccggacc acaccggcga agtcgtcctc cacgaagtcc     2940

cgggagaacc cgagccggtc ggtccagaac tcgaccgctc cggcgacgtc gcgcgcggtg     3000

agcaccggaa cggcactggt caacttggcc atgatggctc ctcctgtcag gagaggaaag     3060

agaagaaggt tagtacaatt gctatagtga gttgtattat actatgcaga tatactatgc     3120

caatgattaa ttgtcaaact agggctgcag ggttcatagt gccacttttc ctgcactgcc     3180

ccatctcctg cccacccttt cccaggcata gacagtcagt gacttaccaa actcacagga     3240

gggagaaggc agaagcttga gacagacccg cgggaccgcc gaactgcgag gggacgtggc     3300

tagggcggct tcttttatgg tgcgccggcc ctcggaggca gggcgctcgg ggaggcctag     3360

cggccaatct gcggtggcag gaggcggggc cgaaggccgt gcctgaccaa tccggagcac     3420

ataggagtct cagccccccg ccccaaagca aggggaagtc acgcgcctgt agcgccagcg     3480

tgttgtgaaa tgggggcttg ggggggttgg ggccctgact agtcaaaaca aactcccatt     3540

gacgtcaatg gggtggagac ttggaaatcc ccgtgagtca aaccgctatc cacgcccatt     3600

gatgtactgc caaaaccgca tcatcatggt aatagcgatg actaatacgt agatgtactg     3660

ccaagtagga aagtcccata aggtcatgta ctgggcataa tgccaggcgg gccatttacc     3720

gtcattgacg tcaatagggg gcgtacttgg catatgatac acttgatgta ctgccaagtg     3780

ggcagtttac cgtaaatact ccacccattg acgtcaatgg aaagtcccta ttggcgttac     3840

tatgggaaca tacgtcatta ttgacgtcaa tgggcggggg tcgttgggcg gtcagccagg     3900

cgggccattt accgtaagtt atgtaacgcc tgcaggttaa ttaagaacat gtgagcaaaa     3960

ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc     4020

cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg aaacccgaca     4080

ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc tcctgttccg     4140

accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt ggcgctttct     4200

catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt     4260

gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag     4320

tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa caggattagc     4380

agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa ctacggctac     4440

actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt cggaaaaaga     4500

gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt ttttgtttgc     4560

aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctacg     4620

gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat ggctagttaa     4680

ttaacattta aatcagcggc cgcaataaaa tatctttatt ttcattacat ctgtgtgttg     4740

gttttttgtg tgaatcgtaa ctaacatacg ctctccatca aaacaaaacg aaacaaaaca     4800

aactagcaaa ataggctgtc cccagtgcaa gtgcaggtgc cagaacattt ctctatcgaa     4860


<210>  31
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  31

Tyr Ser Tyr Pro Gly His His Ser Gly Phe Tyr Ser Gly Tyr His Gly 
1               5                   10                  15      


Ala Phe 
        


<210>  32
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  32

Tyr Ala Tyr Pro Ser Phe Tyr Gly Thr Phe Phe Ala Ser Phe Tyr Gly 
1               5                   10                  15      


Gly Phe 
        


<210>  33
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  33

Phe Thr Phe Pro Gly Leu Phe Thr Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  34
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  34

Phe Ala Phe Pro Gly His His Ala Gly Phe Phe Gly Gly His Leu Gly 
1               5                   10                  15      


Ala Phe 
        


<210>  35
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  35

Tyr Ser Phe Pro Gly His His Gly Gly Phe Phe Ala Thr Tyr Leu Gly 
1               5                   10                  15      


Gly Phe 
        


<210>  36
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  36

Phe Ser Leu Pro Gly Leu Phe Thr Gly Phe Phe Ala Gly Tyr Leu Gly 
1               5                   10                  15      


Ala Phe 
        


<210>  37
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  37

Tyr Ser Tyr Pro Gly His Phe Thr Gly Phe Phe Ser Gly Phe His Gly 
1               5                   10                  15      


Ser Phe 
        


<210>  38
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  38

Tyr Ser Phe Pro Gly His His Gly Gly Phe Phe Ala Thr Tyr Leu Gly 
1               5                   10                  15      


Gly Phe 
        


<210>  39
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  39

Phe Thr Phe Pro Gly Ala Met Asp Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  40
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  40

Phe Thr Phe Pro Gly Asp Phe Ala Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  41
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  41

Phe Thr Phe Pro Gly Asp Phe Asp Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  42
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  42

Phe Thr Phe Pro Gly Asp Phe Arg Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  43
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  43

Phe Thr Phe Pro Gly Leu Phe Asp Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  44
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  44

Phe Thr Phe Pro Gly Pro Phe Asp Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  45
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  45

Phe Ser Phe Pro Gly Leu Phe Asp Gly Phe Phe Arg Ser Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  46
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  46

Phe Ala Phe Pro Gly Leu Phe Asp Gly Phe Phe Arg Asn Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  47
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  47

Phe Ala Phe Pro Gly Leu Phe Asn Gly Phe Phe Arg Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  48
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  48

Phe Thr Phe Pro Gly Leu Phe Asp Gly Phe Phe Arg Asp Tyr Leu Gly 
1               5                   10                  15      


Ser Ile 
        


<210>  49
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  49

Phe Ala Phe Pro Gly Leu Phe Asp Gly Phe Phe Arg Asp Tyr Leu Gly 
1               5                   10                  15      


Ser Ile 
        


<210>  50
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  50

Phe Ala Phe Pro Gly Leu Phe Asp Gly Phe Phe Arg Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  51
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  51

Phe Ala Phe Pro Gly Leu Phe Asp Gly Phe Phe Gly Pro Tyr Leu Gly 
1               5                   10                  15      


Pro Leu 
        


<210>  52
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  52

Ile Ser Tyr Tyr Phe Ile 
1               5       


<210>  53
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  53

Ser Val Tyr Ser Ser Phe Gly Tyr Thr Tyr 
1               5                   10  


<210>  54
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  54

Ala Val Asn Trp Val Gly Ala Leu Val 
1               5                   


<210>  55
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  55

Ser Val Ser Ser Ala 
1               5   


<210>  56
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  56

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  57
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  57

Gly Cys Ala Gly Cys Thr Thr Cys Thr Gly Gly Cys Thr Thr Cys Ala 
1               5                   10                  15      


Ala Cys Met Thr Cys Lys Cys Cys Thr Trp Cys Thr Trp Cys Thr Trp 
            20                  25                  30          


Cys Arg Thr Thr Cys Ala Cys Thr Gly Gly Gly Thr Gly Cys Gly Thr 
        35                  40                  45              


Cys Ala Gly Gly Cys Cys 
    50                  


<210>  58
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  58

Gly Gly Cys Cys Thr Gly Gly Ala Ala Thr Gly Gly Gly Thr Thr Gly 
1               5                   10                  15      


Cys Ala Lys Cys Cys Arg Thr Thr Thr Trp Cys Lys Cys Cys Lys Cys 
            20                  25                  30          


Cys Thr Trp Cys Gly Ser Thr Thr Trp Cys Ala Ser Cys Thr Trp Cys 
        35                  40                  45              


Thr Ala Thr Gly Cys Cys Gly Ala Thr Ala Gly Cys Gly Thr Cys Ala 
    50                  55                  60                  


Ala Gly 
65      


<210>  59
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  59

Gly Thr Cys Thr Ala Thr Thr Ala Thr Thr Gly Thr Gly Cys Thr Cys 
1               5                   10                  15      


Gly Cys Thr Thr Thr Ala Cys Thr Thr Thr Thr Cys Cys Thr Gly Gly 
            20                  25                  30          


Thr Cys Thr Thr Thr Thr Thr Ala Cys Thr Gly Gly Thr Thr Thr Thr 
        35                  40                  45              


Thr Thr Thr Gly Gly Thr Gly Cys Thr Thr Ala Thr Cys Thr Thr Gly 
    50                  55                  60                  


Gly Thr Ala Gly Thr Cys Thr Thr Gly Ala Cys Thr Ala Cys Thr Gly 
65                  70                  75                  80  


Gly Gly Gly Thr Cys Ala Ala Gly Gly Ala 
                85                  90  


<210>  60
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  60

Ala Cys Thr Thr Ala Thr Thr Ala Cys Thr Gly Thr Cys Ala Gly Cys 
1               5                   10                  15      


Ala Ala Lys Cys Cys Arg Thr Thr Met Ala Cys Thr Lys Gly Arg Thr 
            20                  25                  30          


Thr Gly Ser Thr Ser Cys Ala Met Thr Cys Arg Thr Thr Ala Cys Gly 
        35                  40                  45              


Thr Thr Cys Gly Gly Ala Cys Ala Gly Gly Gly Thr Ala Cys Cys 
    50                  55                  60              


<210>  61
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  61

Gly Thr Cys Thr Ala Thr Thr Ala Thr Thr Gly Thr Gly Cys Thr Cys 
1               5                   10                  15      


Gly Cys Asn Asn Lys Asn Asn Lys Asn Asn Lys Asn Asn Lys Asn Asn 
            20                  25                  30          


Lys Cys Thr Thr Thr Thr Thr Ala Cys Thr Gly Gly Thr Thr Thr Thr 
        35                  40                  45              


Thr Thr Thr Gly Gly Thr Gly Cys Thr Thr Ala Thr Cys Thr Thr Gly 
    50                  55                  60                  


Gly Thr Ala Gly Thr Cys Thr Thr Gly Ala Cys Thr Ala Cys Thr Gly 
65                  70                  75                  80  


Gly Gly Gly Thr Cys Ala Ala Gly Gly Ala 
                85                  90  


<210>  62
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  62

Gly Thr Cys Thr Ala Thr Thr Ala Thr Thr Gly Thr Gly Cys Thr Cys 
1               5                   10                  15      


Gly Cys Thr Thr Thr Ala Cys Thr Thr Thr Thr Cys Cys Thr Gly Gly 
            20                  25                  30          


Thr Asn Asn Lys Asn Asn Lys Asn Asn Lys Asn Asn Lys Thr Thr Thr 
        35                  40                  45              


Thr Thr Thr Gly Gly Thr Gly Cys Thr Thr Ala Thr Cys Thr Thr Gly 
    50                  55                  60                  


Gly Thr Ala Gly Thr Cys Thr Thr Gly Ala Cys Thr Ala Cys Thr Gly 
65                  70                  75                  80  


Gly Gly Gly Thr Cys Ala Ala Gly Gly Ala 
                85                  90  


<210>  63
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  63

Gly Thr Cys Thr Ala Thr Thr Ala Thr Thr Gly Thr Gly Cys Thr Cys 
1               5                   10                  15      


Gly Cys Thr Thr Thr Ala Cys Thr Thr Thr Thr Cys Cys Thr Gly Gly 
            20                  25                  30          


Thr Cys Thr Thr Thr Thr Thr Ala Cys Thr Gly Gly Thr Asn Asn Lys 
        35                  40                  45              


Asn Asn Lys Asn Asn Lys Asn Asn Lys Thr Ala Thr Cys Thr Thr Gly 
    50                  55                  60                  


Gly Thr Ala Gly Thr Cys Thr Thr Gly Ala Cys Thr Ala Cys Thr Gly 
65                  70                  75                  80  


Gly Gly Gly Thr Cys Ala Ala Gly Gly Ala 
                85                  90  


<210>  64
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  64

Gly Thr Cys Thr Ala Thr Thr Ala Thr Thr Gly Thr Gly Cys Thr Cys 
1               5                   10                  15      


Gly Cys Thr Thr Thr Ala Cys Thr Thr Thr Thr Cys Cys Thr Gly Gly 
            20                  25                  30          


Thr Cys Thr Thr Thr Thr Thr Ala Cys Thr Gly Gly Thr Thr Thr Thr 
        35                  40                  45              


Thr Thr Thr Gly Gly Thr Gly Cys Thr Asn Asn Lys Asn Asn Lys Asn 
    50                  55                  60                  


Asn Lys Asn Asn Lys Asn Asn Lys Gly Ala Cys Thr Ala Cys Thr Gly 
65                  70                  75                  80  


Gly Gly Gly Thr Cys Ala Ala Gly Gly Ala 
                85                  90  


<210>  65
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  65

Gly Thr Cys Thr Ala Thr Thr Ala Thr Thr Gly Thr Gly Cys Thr Cys 
1               5                   10                  15      


Gly Cys Asn Asn Lys Asn Asn Lys Asn Asn Lys Asn Asn Lys Asn Asn 
            20                  25                  30          


Lys Thr Thr Thr Ala Cys Thr Gly Gly Thr Thr Thr Thr Thr Thr Thr 
        35                  40                  45              


Gly Gly Thr Gly Cys Thr Thr Ala Thr Cys Thr Thr Gly Gly Thr Ala 
    50                  55                  60                  


Gly Thr Cys Thr Thr Gly Ala Cys Thr Ala Cys Thr Gly Gly Gly Gly 
65                  70                  75                  80  


Thr Cys Ala Ala Gly Gly Ala 
                85          


<210>  66
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  66

Gly Thr Cys Thr Ala Thr Thr Ala Thr Thr Gly Thr Gly Cys Thr Cys 
1               5                   10                  15      


Gly Cys Thr Thr Thr Ala Cys Thr Thr Thr Thr Cys Cys Thr Gly Gly 
            20                  25                  30          


Thr Cys Thr Thr Thr Thr Thr Ala Cys Thr Gly Gly Thr Thr Thr Thr 
        35                  40                  45              


Thr Thr Thr Gly Gly Thr Asn Asn Lys Asn Asn Lys Asn Asn Lys Asn 
    50                  55                  60                  


Asn Lys Asn Asn Lys Gly Ala Cys Thr Ala Cys Thr Gly Gly Gly Gly 
65                  70                  75                  80  


Thr Cys Ala Ala Gly Gly Ala 
                85          


<210>  67
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  67

Phe Ser Phe Pro Gly Leu Phe Asp Gly Phe Phe Ser Ser Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  68
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  68

Phe Thr Phe Pro Gly Leu Phe Asp Gly Phe Phe Gly Ser Tyr Leu Gly 
1               5                   10                  15      


Ser Phe 
        


<210>  69
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  69

Phe Thr Phe Pro Gly Leu Phe Asp Gly Phe Phe Arg Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  70
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  70

Phe Ala Phe Pro Gly Leu Phe Glu Gly Phe Phe Arg Gly Tyr Leu Gly 
1               5                   10                  15      


Ser Ile 
        


<210>  71
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  71

Phe Ser Phe Pro Gly Leu Phe Asp Gly Phe Phe Gly Thr Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  72
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  72

Phe Ser Phe Pro Gly Leu Phe Asp Gly Phe Phe Arg Ser Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  73
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  73

Phe Thr Phe Pro Gly Leu Phe Asn Gly Phe Phe Gly Glu Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  74
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  74

Phe Ala Phe Pro Gly Leu Phe Asp Gly Phe Phe Arg Asn Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  75
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  75

Phe Ala Phe Pro Gly Leu Phe Asp Gly Phe Phe Ala Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  76
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  76

Phe Ser Phe Pro Gly Met Phe Asp Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  77
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  77

Phe Ser Phe Pro Gly Leu Phe Asp Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  78
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  78

Phe Ala Phe Pro Gly Leu Phe Asp Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  79
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  79

Phe Ala Phe Pro Gly Gln Phe Asp Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  80
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  80

Phe Ser Phe Pro Gly Leu Phe Asp Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Ile 
        


<210>  81
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  81

Phe Ala Phe Pro Gly Leu Phe Asp Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Ile 
        


<210>  82
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  82

Phe Thr Leu Pro Gly Leu Ile Asn Gly Phe Phe Gly Ala Tyr His Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  83
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  83

Phe Thr Phe Pro Gly Leu Phe Asn Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  84
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  84

Phe Thr Phe Pro Gly Arg Phe Asp Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Ile 
        


<210>  85
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  85

Tyr Thr Phe Pro Gly Leu Phe Asp Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  86
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  86

Phe Thr Phe Pro Gly Leu Phe Asp Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  87
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  87

Phe Ser Phe Pro Gly Leu Phe Asp Gly Phe Phe Arg Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  88
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  88

Phe Ala Phe Pro Gly Leu Phe Asn Gly Phe Phe Arg Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  89
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  89

Phe Ala Phe Pro Gly Leu Phe Asp Gly Phe Phe Arg Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  90
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  90

Phe Thr Phe Pro Gly Leu Phe Asp Gly Phe Phe Ser Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  91
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  91

Phe Ala Phe Pro Gly Leu Phe Asp Gly Phe Phe Ala Glu Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  92
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  92

Phe Thr Phe Pro Gly Leu Phe Asp Gly Phe Phe Gly Val Tyr Leu Gly 
1               5                   10                  15      


Ser Ile 
        


<210>  93
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  93

Phe Thr Leu Pro Gly Leu Phe Ser Gly Phe Phe Gly Tyr Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  94
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  94

Phe Thr Phe Pro Gly Leu Phe Asp Gly Phe Phe Arg Asp Tyr Leu Gly 
1               5                   10                  15      


Ser Ile 
        


<210>  95
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  95

Phe Thr Leu Pro Gly Leu Leu Asp Gly Phe Phe Arg Asp Tyr Ile Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  96
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  96

Phe Ser Phe Pro Gly Leu Phe Asp Gly Phe Phe Gly Gly Phe Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  97
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  97

Phe Ser Phe Pro Gly Leu Phe Asp Gly Phe Phe Gly Asp Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  98
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  98

Phe Thr Phe Pro Gly Leu Phe Asp Gly Phe Phe Gly Asp Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  99
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  99

Phe Ser Val Pro Gly Leu Phe Asp Gly Phe Phe Arg Asp Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  100
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  100

Phe Ala Phe Pro Gly Leu Phe Glu Gly Phe Phe Gly Gly Tyr Leu Gly 
1               5                   10                  15      


Ser Ile 
        


<210>  101
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  101

Phe Thr Phe Pro Gly Leu Phe Asp Gly Phe Phe Gly Ile Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  102
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  102

Phe Ser Phe Pro Gly Lys Phe Asp Gly Phe Phe Gly Ser Tyr Leu Gly 
1               5                   10                  15      


Ser Ile 
        


<210>  103
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  103

Phe Ala Phe Pro Gly Leu Phe Asp Gly Phe Phe Ser Val Phe Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  104
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  104

Phe Ala Phe Pro Gly Leu Phe Asp Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Ile 
        


<210>  105
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  105

Phe Ala Phe Pro Gly Leu Phe Asp Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  106
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  106

Phe Ala Phe Pro Gly Leu Phe Asp Gly Phe Phe Arg Asp Tyr Leu Gly 
1               5                   10                  15      


Ser Ile 
        


<210>  107
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  107

Phe Ala Phe Pro Gly Leu Phe Asp Gly Phe Phe Arg Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  108
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  108

Phe Thr Phe Pro Gly Met Phe Asp Gly Phe Phe Arg Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  109
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  109

Phe Thr Phe Pro Gly Leu Phe Val Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  110
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  110

Phe Thr Phe Pro Gly Gln Phe His Gly Phe Phe Gly Asp Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  111
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  111

Phe Thr Phe Pro Gly Gln Phe Asp Gly Phe Phe Gly Pro Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  112
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  112

Phe Ser Phe Pro Gly Gln Phe Asp Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  113
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  113

Phe Thr Phe Pro Gly Gln Phe Asn Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  114
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  114

Phe Thr Phe Pro Gly Leu Phe Asp Gly Phe Phe Gly Ser Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  115
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  115

Phe Thr Phe Pro Gly Leu Phe Gly Gly Phe Phe Arg Ser Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  116
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  116

Phe Thr Phe Pro Gly Leu Phe Gly Gly Phe Phe Ser Asp Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  117
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  117

Phe Thr Phe Pro Gly Leu Phe Glu Gly Phe Tyr Arg Asp Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  118
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  118

Phe Ala Phe Pro Gly Met Phe Asp Gly Phe Phe Gly Asp Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  119
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  119

Phe Thr Phe Pro Gly Leu Phe Asp Gly Phe Phe Arg Asp Phe Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  120
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  120

Phe Ser Ser Pro Gly Val Phe Ala Gly Phe Phe Gly Ala Tyr Ile Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  121
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  121

Phe Thr Phe Pro Gly Leu Phe Gly Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  122
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  122

Ser Thr Val Pro Gly Leu Phe Asp Gly Phe Phe Gly Ala Tyr His Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  123
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  123

Tyr Ala Phe Pro Gly Leu Phe Asp Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  124
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  124

Phe Thr Phe Pro Gly Arg Phe Asp Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Ile 
        


<210>  125
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  125

Phe Thr Phe Pro Gly Arg Phe Asp Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  126
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  126

Phe Ser Phe Pro Gly Leu Phe Gly Gly Phe Phe Arg Ala Asp Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  127
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  127

Phe Thr Phe Pro Gly Leu Phe Asn Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  128
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  128

Phe Ala Phe Pro Gly Thr Phe Ser Gly Phe Tyr Gly Ala Phe Leu Gly 
1               5                   10                  15      


Ser Ile 
        


<210>  129
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  129

Phe Thr Phe Pro Gly Leu Phe Ser Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  130
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  130

Phe Ser Phe Pro Gly Leu Phe Asn Gly Phe Phe Gly Ala Tyr Ile Gly 
1               5                   10                  15      


Ser Ile 
        


<210>  131
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  131

Phe Thr Phe Pro Gly Leu Leu His Gly Phe Tyr Gly Thr Tyr Ile Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  132
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  132

Tyr Thr Phe Pro Gly Leu Phe Asp Gly Phe Phe Gly Lys Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  133
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  133

Phe Ser Phe Pro Gly Met Phe Asp Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  134
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  134

Phe Thr Phe Pro Gly Leu Phe Asp Gly Phe Phe Ser Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  135
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  135

Phe Thr Phe Pro Gly Leu Phe Gly Gly Phe Phe Gly Gly Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  136
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  136

Tyr Ser Phe Pro Gly Leu Phe Asp Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  137
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  137

Phe Thr Phe Pro Gly Leu Phe Ala Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  138
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  138

Phe Ser Phe Pro Gly Leu Phe His Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  139
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  139

Phe Ala Phe Pro Gly Leu Phe Asp Gly Phe Phe Gly Pro Tyr Leu Gly 
1               5                   10                  15      


Pro Leu 
        


<210>  140
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  140

Phe Thr Phe Pro Gly Ala Phe Thr Gly Phe Phe Gly Ala Tyr Leu Gly 
1               5                   10                  15      


Ser Leu 
        


<210>  141
<211>  89
<212>  DNA
<213>  Homo sapiens

<400>  141
gtctattatt gtgctcgcyw trstywtsyt rstywtywtr strstywtyw trstrstywt       60

ywtrstrsty wtgactactg gggtcaagg                                         89


