                         SEQUENCE LISTING

<110>  Pradip, Raychaudhuri
 
<120>  Methods and Compositions for Inhibiting Tumor Cell Proliferation

<130>  11-1334-US

<150>  US 61/547,671
<151>  2011-10-14

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  2737
<212>  DNA
<213>  Homo sapiens

<400>  1
ggagcccgga gcccgccttc ggagctacgg cctaacggcg gcggcgactg cagtctggag       60

ggtccacact tgtgattctc aatggagagt gaaaacgcag attcataatg aaaactagcc      120

cccgtcggcc actgattctc aaaagacgga ggctgcccct tcctgttcaa aatgccccaa      180

gtgaaacatc agaggaggaa cctaagagat cccctgccca acaggagtct aatcaagcag      240

aggcctccaa ggaagtggca gagtccaact cttgcaagtt tccagctggg atcaagatta      300

ttaaccaccc caccatgccc aacacgcaag tagtggccat ccccaacaat gctaatattc      360

acagcatcat cacagcactg actgccaagg gaaaagagag tggcagtagt gggcccaaca      420

aattcatcct catcagctgt gggggagccc caactcagcc tccaggactc cggcctcaaa      480

cccaaaccag ctatgatgcc aaaaggacag aagtgaccct ggagaccttg ggaccaaaac      540

ctgcagctag ggatgtgaat cttcctagac cacctggagc cctttgcgag cagaaacggg      600

agacctgtgc agatggtgag gcagcaggct gcactatcaa caatagccta tccaacatcc      660

agtggcttcg aaagatgagt tctgatggac tgggctcccg cagcatcaag caagagatgg      720

aggaaaagga gaattgtcac ctggagcagc gacaggttaa ggttgaggag ccttcgagac      780

catcagcgtc ctggcagaac tctgtgtctg agcggccacc ctactcttac atggccatga      840

tacaattcgc catcaacagc actgagagga agcgcatgac tttgaaagac atctatacgt      900

ggattgagga ccactttccc tactttaagc acattgccaa gccaggctgg aagaactcca      960

tccgccacaa cctttccctg cacgacatgt ttgtccggga gacgtctgcc aatggcaagg     1020

tctccttctg gaccattcac cccagtgcca accgctactt gacattggac caggtgttta     1080

agcagcagaa acgaccgaat ccagagctcc gccggaacat gaccatcaaa accgaactcc     1140

ccctgggcgc acggcggaag atgaagccac tgctaccacg ggtcagctca tacctggtac     1200

ctatccagtt cccggtgaac cagtcactgg tgttgcagcc ctcggtgaag gtgccattgc     1260

ccctggcggc ttccctcatg agctcagagc ttgcccgcca tagcaagcga gtccgcattg     1320

cccccaaggt gctgctagct gaggagggga tagctcctct ttcttctgca ggaccaggga     1380

aagaggagaa actcctgttt ggagaagggt tttctccttt gcttccagtt cagactatca     1440

aggaggaaga aatccagcct ggggaggaaa tgccacactt agcgagaccc atcaaagtgg     1500

agagccctcc cttggaagag tggccctccc cggccccatc tttcaaagag gaatcatctc     1560

actcctggga ggattcgtcc caatctccca ccccaagacc caagaagtcc tacagtgggc     1620

ttaggtcccc aacccggtgt gtctcggaaa tgcttgtgat tcaacacagg gagaggaggg     1680

agaggagccg gtctcggagg aaacagcatc tactgcctcc ctgtgtggat gagccggagc     1740

tgctcttctc agaggggccc agtacttccc gctgggccgc agagctcccg ttcccagcag     1800

actcctctga ccctgcctcc cagctcagct actcccagga agtgggagga ccttttaaga     1860

cacccattaa ggaaacgctg cccatctcct ccaccccgag caaatctgtc ctccccagaa     1920

cccctgaatc ctggaggctc acgcccccag ccaaagtagg gggactggat ttcagcccag     1980

tacaaacctc ccagggtgcc tctgacccct tgcctgaccc cctggggctg atggatctca     2040

gcaccactcc cttgcaaagt gctccccccc ttgaatcacc gcaaaggctc ctcagttcag     2100

aacccttaga cctcatctcc gtcccctttg gcaactcttc tccctcagat atagacgtcc     2160

ccaagccagg ctccccggag ccacaggttt ctggccttgc agccaatcgt tctctgacag     2220

aaggcctggt cctggacaca atgaatgaca gcctcagcaa gatcctgctg gacatcagct     2280

ttcctggcct ggacgaggac ccactgggcc ctgacaacat caactggtcc cagtttattc     2340

ctgagctaca gtagagccct gcccttgccc ctgtgctcaa gctgtccacc atcccgggca     2400

ctccaaggct cagtgcaccc caagcctctg agtgaggaca gcaggcaggg actgttctgc     2460

tcctcatagc tccctgctgc ctgattatgc aaaagtagca gtcacaccct agccactgct     2520

gggaccttgt gttccccaag agtatctgat tcctctgctg tccctgccag gagctgaagg     2580

gtgggaacaa caaaggcaat ggtgaaaaga gattaggaac cccccagcct gtttccattc     2640

tctgcccagc agtctcttac cttccctgat ctttgcaggg tggtccgtgt aaatagtata     2700

aattctccaa attatcctct aattataaat gtaagct                              2737


<210>  2
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Thr Ser Pro Arg Arg Pro Leu Ile Leu Lys Arg Arg Arg Leu 
1               5                   10                  15      


Pro Leu Pro Val Gln Asn Ala Pro Ser Glu Thr Ser Glu Glu Glu Pro 
            20                  25                  30          


Lys Arg Ser Pro Ala Gln Gln Glu Ser Asn Gln Ala Glu Ala Ser Lys 
        35                  40                  45              


Glu Val Ala Glu Ser Asn Ser Cys Lys Phe Pro Ala Gly Ile Lys Ile 
    50                  55                  60                  


Ile Asn His Pro Thr Met Pro Asn Thr Gln Val Val Ala Ile Pro Asn 
65                  70                  75                  80  


Asn Ala Asn Ile His Ser Ile Ile Thr Ala Leu Thr Ala Lys Gly Lys 
                85                  90                  95      


Glu Ser Gly Ser Ser Gly Pro Asn Lys Phe Ile Leu Ile Ser Cys Gly 
            100                 105                 110         


Gly Ala Pro Thr Gln Pro Pro Gly Leu Arg Pro Gln Thr Gln Thr Ser 
        115                 120                 125             


Tyr Asp Ala Lys Arg Thr Glu Val Thr Leu Glu Thr Leu Gly Pro Lys 
    130                 135                 140                 


Pro Ala Ala Arg Asp Val Asn Leu Pro Arg Pro Pro Gly Ala Leu Cys 
145                 150                 155                 160 


Glu Gln Lys Arg Glu Thr Cys Ala Asp Gly Glu Ala Ala Gly Cys Thr 
                165                 170                 175     


Ile Asn Asn Ser Leu Ser Asn Ile Gln Trp Leu Arg Lys Met Ser Ser 
            180                 185                 190         


Asp Gly Leu Gly Ser Arg Ser Ile Lys Gln Glu Met Glu Glu Lys Glu 
        195                 200                 205             


Asn Cys His Leu Glu Gln Arg Gln Val Lys Val Glu Glu Pro Ser Arg 
    210                 215                 220                 


Pro Ser Ala Ser Trp Gln Asn Ser Val Ser Glu Arg Pro Pro Tyr Ser 
225                 230                 235                 240 


Tyr Met Ala Met Ile Gln Phe Ala Ile Asn Ser Thr Glu Arg Lys Arg 
                245                 250                 255     


Met Thr Leu Lys Asp Ile Tyr Thr Trp Ile Glu Asp His Phe Pro Tyr 
            260                 265                 270         


Phe Lys His Ile Ala Lys Pro Gly Trp Lys Asn Ser Ile Arg His Asn 
        275                 280                 285             


Leu Ser Leu His Asp Met Phe Val Arg Glu Thr Ser Ala Asn Gly Lys 
    290                 295                 300                 


Val Ser Phe Trp Thr Ile His Pro Ser Ala Asn Arg Tyr Leu Thr Leu 
305                 310                 315                 320 


Asp Gln Val Phe Lys Gln Gln Lys Arg Pro Asn Pro Glu Leu Arg Arg 
                325                 330                 335     


Asn Met Thr Ile Lys Thr Glu Leu Pro Leu Gly Ala Arg Arg Lys Met 
            340                 345                 350         


Lys Pro Leu Leu Pro Arg Val Ser Ser Tyr Leu Val Pro Ile Gln Phe 
        355                 360                 365             


Pro Val Asn Gln Ser Leu Val Leu Gln Pro Ser Val Lys Val Pro Leu 
    370                 375                 380                 


Pro Leu Ala Ala Ser Leu Met Ser Ser Glu Leu Ala Arg His Ser Lys 
385                 390                 395                 400 


Arg Val Arg Ile Ala Pro Lys Val Leu Leu Ala Glu Glu Gly Ile Ala 
                405                 410                 415     


Pro Leu Ser Ser Ala Gly Pro Gly Lys Glu Glu Lys Leu Leu Phe Gly 
            420                 425                 430         


Glu Gly Phe Ser Pro Leu Leu Pro Val Gln Thr Ile Lys Glu Glu Glu 
        435                 440                 445             


Ile Gln Pro Gly Glu Glu Met Pro His Leu Ala Arg Pro Ile Lys Val 
    450                 455                 460                 


Glu Ser Pro Pro Leu Glu Glu Trp Pro Ser Pro Ala Pro Ser Phe Lys 
465                 470                 475                 480 


Glu Glu Ser Ser His Ser Trp Glu Asp Ser Ser Gln Ser Pro Thr Pro 
                485                 490                 495     


Arg Pro Lys Lys Ser Tyr Ser Gly Leu Arg Ser Pro Thr Arg Cys Val 
            500                 505                 510         


Ser Glu Met Leu Val Ile Gln His Arg Glu Arg Arg Glu Arg Ser Arg 
        515                 520                 525             


Ser Arg Arg Lys Gln His Leu Leu Pro Pro Cys Val Asp Glu Pro Glu 
    530                 535                 540                 


Leu Leu Phe Ser Glu Gly Pro Ser Thr Ser Arg Trp Ala Ala Glu Leu 
545                 550                 555                 560 


Pro Phe Pro Ala Asp Ser Ser Asp Pro Ala Ser Gln Leu Ser Tyr Ser 
                565                 570                 575     


Gln Glu Val Gly Gly Pro Phe Lys Thr Pro Ile Lys Glu Thr Leu Pro 
            580                 585                 590         


Ile Ser Ser Thr Pro Ser Lys Ser Val Leu Pro Arg Thr Pro Glu Ser 
        595                 600                 605             


Trp Arg Leu Thr Pro Pro Ala Lys Val Gly Gly Leu Asp Phe Ser Pro 
    610                 615                 620                 


Val Gln Thr Ser Gln Gly Ala Ser Asp Pro Leu Pro Asp Pro Leu Gly 
625                 630                 635                 640 


Leu Met Asp Leu Ser Thr Thr Pro Leu Gln Ser Ala Pro Pro Leu Glu 
                645                 650                 655     


Ser Pro Gln Arg Leu Leu Ser Ser Glu Pro Leu Asp Leu Ile Ser Val 
            660                 665                 670         


Pro Phe Gly Asn Ser Ser Pro Ser Asp Ile Asp Val Pro Lys Pro Gly 
        675                 680                 685             


Ser Pro Glu Pro Gln Val Ser Gly Leu Ala Ala Asn Arg Ser Leu Thr 
    690                 695                 700                 


Glu Gly Leu Val Leu Asp Thr Met Asn Asp Ser Leu Ser Lys Ile Leu 
705                 710                 715                 720 


Leu Asp Ile Ser Phe Pro Gly Leu Asp Glu Asp Pro Leu Gly Pro Asp 
                725                 730                 735     


Asn Ile Asn Trp Ser Gln Phe Ile Pro Glu Leu Gln 
            740                 745             


<210>  3
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  Xaa is any amino acid

<400>  3

Leu Xaa Leu Xaa Xaa Leu 
1               5       


<210>  4
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic, 5' EcoR1 T-epitope tagged FoxM1B primer

<400>  4
gcggaattca ccatggctag catgactggt ggacagcaaa tgggttggca gaactctgtg       60

tctgag                                                                  66


<210>  5
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic; antisense primer for CMV expression vector SV-40 poly 
       A region

<400>  5
gtttgtccaa ttatgtca                                                     18


<210>  6
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FoxM1B/FoxA binding site

<400>  6
tttgtttgtt tg                                                           12


<210>  7
<211>  6
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic; transcription termination signal

<400>  7
aauaaa                                                                   6


<210>  8
<211>  82
<212>  PRT
<213>  Homo sapiens

<400>  8

Pro Phe Lys Thr Pro Ile Lys Glu Thr Leu Pro Ile Ser Ser Thr Pro 
1               5                   10                  15      


Ser Lys Ser Val Leu Pro Arg Thr Pro Glu Ser Trp Arg Leu Thr Pro 
            20                  25                  30          


Pro Ala Lys Val Gly Gly Leu Asp Thr Phe Ser Pro Val Gln Thr Ser 
        35                  40                  45              


Gln Gly Ala Ser Asp Pro Leu Pro Asp Pro Leu Gly Leu Met Asp Leu 
    50                  55                  60                  


Ser Thr Thr Pro Leu Gln Ser Ala Pro Pro Leu Glu Ser Pro Gln Arg 
65                  70                  75                  80  


Leu Leu 
        


<210>  9
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic, LXLXXL motif from FoxM1B amino acid residue 635 to 662


<220>
<221>  MISC_FEATURE
<222>  (2)..(4)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(9)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(14)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(26)
<223>  Xaa is any amino acid

<400>  9

Leu Xaa Xaa Xaa Leu Xaa Leu Xaa Xaa Leu Xaa Xaa Xaa Xaa Leu Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Leu Leu 
            20                  25              


<210>  10
<211>  28
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  Xaa is D-Arginine

<400>  10

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Phe Val Arg Ser Arg Arg 
1               5                   10                  15      


Pro Arg Thr Ala Ser Cys Ala Leu Ala Phe Val Asn 
            20                  25              


<210>  11
<211>  19
<212>  PRT
<213>  Mus musculus

<400>  11

Lys Phe Val Arg Ser Arg Arg Pro Arg Thr Ala Ser Cys Ala Leu Ala 
1               5                   10                  15      


Phe Val Asn 
            


<210>  12
<211>  30
<212>  PRT
<213>  Mus musculus

<400>  12

Lys Phe Val Arg Ser Arg Arg Pro Arg Thr Ala Ser Cys Ala Leu Ala 
1               5                   10                  15      


Phe Val Asn Met Leu Leu Arg Leu Glu Arg Ile Leu Arg Arg 
            20                  25                  30  


<210>  13
<211>  13
<212>  PRT
<213>  Human immunodeficiency virus

<400>  13

Met Gly Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10              


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  Xaa is D-Arginine

<400>  14

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   


<210>  15
<211>  169
<212>  PRT
<213>  Mus musculus

<400>  15

Met Gly Arg Arg Phe Leu Val Thr Val Arg Ile Gln Arg Ala Gly Arg 
1               5                   10                  15      


Pro Leu Gln Glu Arg Val Phe Leu Val Lys Phe Val Arg Ser Arg Arg 
            20                  25                  30          


Pro Arg Thr Ala Ser Cys Ala Leu Ala Phe Val Asn Met Leu Leu Arg 
        35                  40                  45              


Leu Glu Arg Ile Leu Arg Arg Gly Pro His Arg Asn Pro Gly Pro Gly 
    50                  55                  60                  


Asp Asp Asp Gly Gln Arg Ser Arg Ser Ser Ser Ser Ala Gln Leu Arg 
65                  70                  75                  80  


Cys Arg Phe Glu Leu Arg Gly Pro His Tyr Leu Leu Pro Pro Gly Asp 
                85                  90                  95      


Arg Arg Ser Ala Gly Arg Leu Pro Gly His Ala Gly Gly Ala Ala Arg 
            100                 105                 110         


Val Arg Gly Ser Ala Gly Cys Ala Arg Cys Leu Gly Ser Pro Ala Ala 
        115                 120                 125             


Arg Leu Gly Pro Arg Ala Gly Thr Ser Arg His Arg Ala Ile Phe Ala 
    130                 135                 140                 


Phe Arg Trp Val Leu Phe Val Phe Arg Trp Val Val Phe Val Tyr Arg 
145                 150                 155                 160 


Trp Glu Arg Arg Pro Asp Arg Arg Ala 
                165                 


<210>  16
<211>  19
<212>  PRT
<213>  Mus musculus

<400>  16

Lys Phe Val Arg Ser Arg Arg Pro Arg Thr Ala Ser Cys Ala Leu Ala 
1               5                   10                  15      


Phe Val Asn 
            


<210>  17
<211>  13
<212>  PRT
<213>  Human immunodeficiency virus

<400>  17

Met Gly Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10              


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  Xaa is D-Arginine

<400>  18

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   


<210>  19
<211>  28
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  Xaa is D-Arginine

<400>  19

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Phe Val Arg Ser Arg Arg 
1               5                   10                  15      


Pro Arg Thr Ala Ser Cys Ala Leu Ala Phe Val Asn 
            20                  25              


<210>  20
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Val Arg Arg Phe Leu Val Thr Leu Arg Ile Arg Arg Ala Cys Gly 
1               5                   10                  15      


Pro Pro Arg Val Arg Val Phe Val Val His Ile Pro Arg Leu Thr Gly 
            20                  25                  30          


Glu Trp Ala Ala Pro Gly Ala Pro Ala Ala Val Ala Leu Val Leu Met 
        35                  40                  45              


Leu Leu Arg Ser Gln Arg Leu Gly Gln Pro Leu Pro Arg Arg Pro Gly 
    50                  55                  60                  


His Asp Asp Gly Gln Arg Pro Ser Gly Gly Ala Ala Ala Ala Pro Arg 
65                  70                  75                  80  


Arg Gly Ala Gln Leu Arg Arg Pro Arg His Ser His Pro Thr Arg Ala 
                85                  90                  95      


Arg Arg Cys Pro Gly Gly Leu Pro Gly His Ala Gly Gly Ala Ala Pro 
            100                 105                 110         


Gly Arg Gly Ala Ala Gly Arg Ala Arg Cys Leu Gly Pro Ser Ala Arg 
        115                 120                 125             


Gly Pro Gly 
    130     


