                         SEQUENCE LISTING

<110>  Aerpio Therapeutics, Inc.
       Peters, Kevin
       Shalwitz, Robert
 
<120>  Treatment of Ocular Disease

<130>  233106-331562

<150>  US 61/546,708
<151>  2011-10-13

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  6045
<212>  DNA
<213>  Homo sapiens

<400>  1
atgctgagcc atggagccgg gttggccttg tggatcacac tgagcctgct gcagactgga       60

ctggcggagc cagagagatg taacttcacc ctggcggagt ccaaggcctc cagccattct      120

gtgtctatcc agtggagaat tttgggctca ccctgtaact ttagcctcat ctatagcagt      180

gacaccctgg gggccgcgtt gtgccctacc tttcggatag acaacaccac atacggatgt      240

aaccttcaag atttacaagc aggaaccatc tataacttca agattatttc tctggatgaa      300

gagagaactg tggtcttgca aacagatcct ttacctcctg ctaggtttgg agtcagtaaa      360

gagaagacga cttcaaccgg cttgcatgtt tggtggactc cttcttccgg aaaagtcacc      420

tcatatgagg tgcaattatt tgatgaaaat aaccaaaaga tacagggggt tcaaattcaa      480

gaaagtactt catggaatga atacactttt ttcaatctca ctgctggtag taaatacaat      540

attgccatca cagctgtttc tggaggaaaa cgttcttttt cagtttatac caatggatca      600

acagtgccat ctccagtgaa agatattggt atttccacaa aagccaattc tctcctgatt      660

tcctggtccc atggttctgg gaatgtggaa cgataccggc tgatgctaat ggataaaggg      720

atcctagttc atggcggtgt tgtggacaaa catgctactt cctatgcttt tcacgggctg      780

tcccctggct acctctacaa cctcactgtt atgactgagg ctgcagggct gcaaaactac      840

aggtggaaac tagtcaggac agcccccatg gaagtctcaa atctgaaggt gacaaatgat      900

ggcagtttga cctctctaaa agtcaaatgg caaagacctc ctggaaatgt ggattcttac      960

aatatcaccc tgtctcacaa agggaccatc aaggaatcca gagtattagc accttggatt     1020

actgaaactc actttaaaga gttagtcccc ggtcgacttt atcaagttac tgtcagctgt     1080

gtctctggtg aactgtctgc tcagaagatg gcagtgggca gaacatttcc agacaaagtt     1140

gcaaacctgg aggcaaacaa taatggcagg atgaggtctc ttgtagtgag ctggtcgccc     1200

cctgctggag actgggagca gtatcggatc ctactcttca atgattctgt ggtgctgctc     1260

aacatcactg tgggaaagga agaaacacag tatgtcatgg atgacacggg gctcgtaccg     1320

ggaagacagt atgaggtgga agtcattgtt gagagtggaa atttgaagaa ttctgagcgt     1380

tgccaaggca ggacagtccc cctggctgtc ctccagcttc gtgtcaaaca tgccaatgaa     1440

acctcactga gtatcatgtg gcagacccct gtagcagaat gggagaaata catcatttcc     1500

ctagctgaca gagacctctt actgatccac aagtcactct ccaaagatgc caaagaattc     1560

acttttactg acctggtgcc tggacgaaaa tacatggcta cagtcaccag tattagtgga     1620

gacttaaaaa attcctcttc agtaaaagga agaacagtgc ctgcccaagt gactgacttg     1680

catgtggcca accaaggaat gaccagtagt ctgtttacta actggaccca ggcacaagga     1740

gacgtagaat tttaccaagt cttactgatc catgaaaatg tggtcattaa aaatgaaagc     1800

atctccagtg agaccagcag atacagcttc cactctctca agtccggcag cctgtactcc     1860

gtggtggtaa caacagtgag tggagggatc tcttcccgac aagtggttgt ggagggaaga     1920

acagtccctt ccagtgtgag tggagtaacg gtgaacaatt ccggtcgtaa tgactacctc     1980

agcgtttcct ggctcgtggc gcccggagat gtggataact atgaggtaac attgtctcat     2040

gacggcaagg tggttcagtc ccttgtcatt gccaagtctg tcagagaatg ttccttcagc     2100

tccctcaccc caggccgcct ctacaccgtg accataacta caaggagtgg caagtatgaa     2160

aatcactcct tcagccaaga gcggacagtg cctgacaaag tccagggagt cagtgttagc     2220

aactcagcca ggagtgacta tttaagggta tcctgggtgc atgccactgg agactttgat     2280

cactatgaag tcaccattaa aaacaaaaac aacttcattc aaactaaaag cattcccaag     2340

tcagaaaacg aatgtgtatt tgttcagcta gtccctggac ggttgtacag tgtcactgtt     2400

actacaaaaa gtggacaata tgaagccaat gaacaaggga atgggagaac aattccagag     2460

cctgttaagg atctaacatt gcgcaacagg agcactgagg acttgcatgt gacttggtca     2520

ggagctaatg gggatgtcga ccaatatgag atccagctgc tcttcaatga catgaaagta     2580

tttcctcctt ttcaccttgt aaataccgca accgagtatc gatttacttc cctaacacca     2640

ggccgccaat acaaaattct tgtcttgacg attagcgggg atgtacagca gtcagccttc     2700

attgagggct tcacagttcc tagtgctgtc aaaaatattc acatttctcc caatggagca     2760

acagatagcc tgacggtgaa ctggactcct ggtgggggag acgttgattc ctacacggtg     2820

tcggcattca ggcacagtca aaaggttgac tctcagacta ttcccaagca cgtctttgag     2880

cacacgttcc acagactgga ggccggggag cagtaccaga tcatgattgc ctcagtcagc     2940

gggtccctga agaatcagat aaatgtggtt gggcggacag ttccagcatc tgtccaagga     3000

gtaattgcag acaatgcata cagcagttat tccttaatag taagttggca aaaagctgct     3060

ggtgtggcag aaagatatga tatcctgctt ctaactgaaa atggaatcct tctgcgcaac     3120

acatcagagc cagccaccac taagcaacac aaatttgaag atctaacacc aggcaagaaa     3180

tacaagatac agatcctaac tgtcagtgga ggcctcttta gcaaggaagc ccagactgaa     3240

ggccgaacag tcccagcagc tgtcaccgac ctgaggatca cagagaactc caccaggcac     3300

ctgtccttcc gctggaccgc ctcagagggg gagctcagct ggtacaacat ctttttgtac     3360

aacccagatg ggaatctcca ggagagagct caagttgacc cactagtcca gagcttctct     3420

ttccagaact tgctacaagg cagaatgtac aagatggtga ttgtaactca cagtggggag     3480

ctgtctaatg agtctttcat atttggtaga acagtcccag cctctgtgag tcatctcagg     3540

gggtccaatc ggaacacgac agacagcctt tggttcaact ggagtccagc ctctggggac     3600

tttgactttt atgagctgat tctctataat cccaatggca caaagaagga aaactggaaa     3660

gacaaggacc tgacggagtg gcggtttcaa ggccttgttc ctggaaggaa gtacgtgctg     3720

tgggtggtaa ctcacagtgg agatctcagc aataaagtca cagcggagag cagaacagct     3780

ccaagtcctc ccagtcttat gtcatttgct gacattgcaa acacatcctt ggccatcacg     3840

tggaaagggc ccccagactg gacagactac aacgactttg agctgcagtg gttgcccaga     3900

gatgcactta ctgtcttcaa cccctacaac aacagaaaat cagaaggacg cattgtgtat     3960

ggtcttcgtc cagggagatc ctatcaattc aacgtcaaga ctgtcagtgg tgattcctgg     4020

aaaacttaca gcaaaccaat ttttggatct gtgaggacaa agcctgacaa gatacaaaac     4080

ctgcattgcc ggcctcagaa ctccacggcc attgcctgtt cttggatccc tcctgattct     4140

gactttgatg gttatagtat tgaatgccgg aaaatggaca cccaagaagt tgagttttcc     4200

agaaagctgg agaaagaaaa atctctgctc aacatcatga tgctagtgcc ccataagagg     4260

tacctggtgt ccatcaaagt gcagtcggcc ggcatgacca gcgaggtggt tgaagacagc     4320

actatcacaa tgatagaccg cccccctcct ccacccccac acattcgtgt gaatgaaaag     4380

gatgtgctaa ttagcaagtc ttccatcaac tttactgtca actgcagctg gttcagcgac     4440

accaatggag ctgtgaaata cttcacagtg gtggtgagag aggctgatgg cagtgatgag     4500

ctgaagccag aacagcagca ccctctccct tcctacctgg agtacaggca caatgcctcc     4560

attcgggtgt atcagactaa ttattttgcc agcaaatgtg ccgaaaatcc taacagcaac     4620

tccaagagtt ttaacattaa gcttggagca gagatggaga gcttaggtgg aaaacgcgat     4680

cccactcagc aaaaattctg tgatggacca ctgaagccac acactgccta cagaatcagc     4740

attcgagctt ttacacagct ctttgatgag gacctgaagg aattcacaaa gccactctat     4800

tcagacacat ttttttcttt acccatcact actgaatcag agcccttgtt tggagctatt     4860

gaaggtgtga gtgctggtct gtttttaatt ggcatgctag tggctgttgt tgccttattg     4920

atctgcagac agaaagtgag ccatggtcga gaaagaccct ctgcccgtct gagcattcgt     4980

agggatcgac cattatctgt ccacttaaac ctgggccaga aaggtaaccg gaaaacttct     5040

tgtccaataa aaataaatca gtttgaaggg catttcatga agctacaggc tgactccaac     5100

taccttctat ccaaggaata cgaggagtta aaagacgtgg gccgaaacca gtcatgtgac     5160

attgcactct tgccggagaa tagagggaaa aatcgataca acaatatatt gccctatgat     5220

gccacgcgag tgaagctctc caatgtagat gatgatcctt gctctgacta catcaatgcc     5280

agctacatcc ctggcaacaa cttcagaaga gaatacattg tcactcaggg accgcttcct     5340

ggcaccaagg atgacttctg gaaaatggtg tgggaacaaa acgttcacaa catcgtcatg     5400

gtgacccagt gtgttgagaa gggccgagta aagtgtgacc attactggcc agcggaccag     5460

gattccctct actatgggga cctcatcctg cagatgctct cagagtccgt cctgcctgag     5520

tggaccatcc gggagtttaa gatatgcggt gaggaacagc ttgatgcaca cagactcatc     5580

cgccactttc actatacggt gtggccagac catggagtcc cagaaaccac ccagtctctg     5640

atccagtttg tgagaactgt cagggactac atcaacagaa gcccgggtgc tgggcccact     5700

gtggtgcact gcagtgctgg tgtgggtagg actggaacct ttattgcatt ggaccgaatc     5760

ctccagcagt tagactccaa agactctgtg gacatttatg gagcagtgca cgacctaaga     5820

cttcacaggg ttcacatggt ccagactgag tgtcagtatg tctacctaca tcagtgtgta     5880

agagatgtcc tcagagcaag aaagctacgg agtgaacaag aaaacccctt gtttccaatc     5940

tatgaaaatg tgaatccaga gtatcacaga gatccagtct attcaaggca ttgagaatgt     6000

acctgaagag ctcctggata aaaattattc actgtgtgat ttgtt                     6045


<210>  2
<211>  1997
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Ser His Gly Ala Gly Leu Ala Leu Trp Ile Thr Leu Ser Leu 
1               5                   10                  15      


Leu Gln Thr Gly Leu Ala Glu Pro Glu Arg Cys Asn Phe Thr Leu Ala 
            20                  25                  30          


Glu Ser Lys Ala Ser Ser His Ser Val Ser Ile Gln Trp Arg Ile Leu 
        35                  40                  45              


Gly Ser Pro Cys Asn Phe Ser Leu Ile Tyr Ser Ser Asp Thr Leu Gly 
    50                  55                  60                  


Ala Ala Leu Cys Pro Thr Phe Arg Ile Asp Asn Thr Thr Tyr Gly Cys 
65                  70                  75                  80  


Asn Leu Gln Asp Leu Gln Ala Gly Thr Ile Tyr Asn Phe Arg Ile Ile 
                85                  90                  95      


Ser Leu Asp Glu Glu Arg Thr Val Val Leu Gln Thr Asp Pro Leu Pro 
            100                 105                 110         


Pro Ala Arg Phe Gly Val Ser Lys Glu Lys Thr Thr Ser Thr Ser Leu 
        115                 120                 125             


His Val Trp Trp Thr Pro Ser Ser Gly Lys Val Thr Ser Tyr Glu Val 
    130                 135                 140                 


Gln Leu Phe Asp Glu Asn Asn Gln Lys Ile Gln Gly Val Gln Ile Gln 
145                 150                 155                 160 


Glu Ser Thr Ser Trp Asn Glu Tyr Thr Phe Phe Asn Leu Thr Ala Gly 
                165                 170                 175     


Ser Lys Tyr Asn Ile Ala Ile Thr Ala Val Ser Gly Gly Lys Arg Ser 
            180                 185                 190         


Phe Ser Val Tyr Thr Asn Gly Ser Thr Val Pro Ser Pro Val Lys Asp 
        195                 200                 205             


Ile Gly Ile Ser Thr Lys Ala Asn Ser Leu Leu Ile Ser Trp Ser His 
    210                 215                 220                 


Gly Ser Gly Asn Val Glu Arg Tyr Arg Leu Met Leu Met Asp Lys Gly 
225                 230                 235                 240 


Ile Leu Val His Gly Gly Val Val Asp Lys His Ala Thr Ser Tyr Ala 
                245                 250                 255     


Phe His Gly Leu Thr Pro Gly Tyr Leu Tyr Asn Leu Thr Val Met Thr 
            260                 265                 270         


Glu Ala Ala Gly Leu Gln Asn Tyr Arg Trp Lys Leu Val Arg Thr Ala 
        275                 280                 285             


Pro Met Glu Val Ser Asn Leu Lys Val Thr Asn Asp Gly Ser Leu Thr 
    290                 295                 300                 


Ser Leu Lys Val Lys Trp Gln Arg Pro Pro Gly Asn Val Asp Ser Tyr 
305                 310                 315                 320 


Asn Ile Thr Leu Ser His Lys Gly Thr Ile Lys Glu Ser Arg Val Leu 
                325                 330                 335     


Ala Pro Trp Ile Thr Glu Thr His Phe Lys Glu Leu Val Pro Gly Arg 
            340                 345                 350         


Leu Tyr Gln Val Thr Val Ser Cys Val Ser Gly Glu Leu Ser Ala Gln 
        355                 360                 365             


Lys Met Ala Val Gly Arg Thr Phe Pro Asp Lys Val Ala Asn Leu Glu 
    370                 375                 380                 


Ala Asn Asn Asn Gly Arg Met Arg Ser Leu Val Val Ser Trp Ser Pro 
385                 390                 395                 400 


Pro Ala Gly Asp Trp Glu Gln Tyr Arg Ile Leu Leu Phe Asn Asp Ser 
                405                 410                 415     


Val Val Leu Leu Asn Ile Thr Val Gly Lys Glu Glu Thr Gln Tyr Val 
            420                 425                 430         


Met Asp Asp Thr Gly Leu Val Pro Gly Arg Gln Tyr Glu Val Glu Val 
        435                 440                 445             


Ile Val Glu Ser Gly Asn Leu Lys Asn Ser Glu Arg Cys Gln Gly Arg 
    450                 455                 460                 


Thr Val Pro Leu Ala Val Leu Gln Leu Arg Val Lys His Ala Asn Glu 
465                 470                 475                 480 


Thr Ser Leu Ser Ile Met Trp Gln Thr Pro Val Ala Glu Trp Glu Lys 
                485                 490                 495     


Tyr Ile Ile Ser Leu Ala Asp Arg Asp Leu Leu Leu Ile His Lys Ser 
            500                 505                 510         


Leu Ser Lys Asp Ala Lys Glu Phe Thr Phe Thr Asp Leu Val Pro Gly 
        515                 520                 525             


Arg Lys Tyr Met Ala Thr Val Thr Ser Ile Ser Gly Asp Leu Lys Asn 
    530                 535                 540                 


Ser Ser Ser Val Lys Gly Arg Thr Val Pro Ala Gln Val Thr Asp Leu 
545                 550                 555                 560 


His Val Ala Asn Gln Gly Met Thr Ser Ser Leu Phe Thr Asn Trp Thr 
                565                 570                 575     


Gln Ala Gln Gly Asp Val Glu Phe Tyr Gln Val Leu Leu Ile His Glu 
            580                 585                 590         


Asn Val Val Ile Lys Asn Glu Ser Ile Ser Ser Glu Thr Ser Arg Tyr 
        595                 600                 605             


Ser Phe His Ser Leu Lys Ser Gly Ser Leu Tyr Ser Val Val Val Thr 
    610                 615                 620                 


Thr Val Ser Gly Gly Ile Ser Ser Arg Gln Val Val Val Glu Gly Arg 
625                 630                 635                 640 


Thr Val Pro Ser Ser Val Ser Gly Val Thr Val Asn Asn Ser Gly Arg 
                645                 650                 655     


Asn Asp Tyr Leu Ser Val Ser Trp Leu Leu Ala Pro Gly Asp Val Asp 
            660                 665                 670         


Asn Tyr Glu Val Thr Leu Ser His Asp Gly Lys Val Val Gln Ser Leu 
        675                 680                 685             


Val Ile Ala Lys Ser Val Arg Glu Cys Ser Phe Ser Ser Leu Thr Pro 
    690                 695                 700                 


Gly Arg Leu Tyr Thr Val Thr Ile Thr Thr Arg Ser Gly Lys Tyr Glu 
705                 710                 715                 720 


Asn His Ser Phe Ser Gln Glu Arg Thr Val Pro Asp Lys Val Gln Gly 
                725                 730                 735     


Val Ser Val Ser Asn Ser Ala Arg Ser Asp Tyr Leu Arg Val Ser Trp 
            740                 745                 750         


Val His Ala Thr Gly Asp Phe Asp His Tyr Glu Val Thr Ile Lys Asn 
        755                 760                 765             


Lys Asn Asn Phe Ile Gln Thr Lys Ser Ile Pro Lys Ser Glu Asn Glu 
    770                 775                 780                 


Cys Val Phe Val Gln Leu Val Pro Gly Arg Leu Tyr Ser Val Thr Val 
785                 790                 795                 800 


Thr Thr Lys Ser Gly Gln Tyr Glu Ala Asn Glu Gln Gly Asn Gly Arg 
                805                 810                 815     


Thr Ile Pro Glu Pro Val Lys Asp Leu Thr Leu Arg Asn Arg Ser Thr 
            820                 825                 830         


Glu Asp Leu His Val Thr Trp Ser Gly Ala Asn Gly Asp Val Asp Gln 
        835                 840                 845             


Tyr Glu Ile Gln Leu Leu Phe Asn Asp Met Lys Val Phe Pro Pro Phe 
    850                 855                 860                 


His Leu Val Asn Thr Ala Thr Glu Tyr Arg Phe Thr Ser Leu Thr Pro 
865                 870                 875                 880 


Gly Arg Gln Tyr Lys Ile Leu Val Leu Thr Ile Ser Gly Asp Val Gln 
                885                 890                 895     


Gln Ser Ala Phe Ile Glu Gly Phe Thr Val Pro Ser Ala Val Lys Asn 
            900                 905                 910         


Ile His Ile Ser Pro Asn Gly Ala Thr Asp Ser Leu Thr Val Asn Trp 
        915                 920                 925             


Thr Pro Gly Gly Gly Asp Val Asp Ser Tyr Thr Val Ser Ala Phe Arg 
    930                 935                 940                 


His Ser Gln Lys Val Asp Ser Gln Thr Ile Pro Lys His Val Phe Glu 
945                 950                 955                 960 


His Thr Phe His Arg Leu Glu Ala Gly Glu Gln Tyr Gln Ile Met Ile 
                965                 970                 975     


Ala Ser Val Ser Gly Ser Leu Lys Asn Gln Ile Asn Val Val Gly Arg 
            980                 985                 990         


Thr Val Pro Ala Ser Val Gln Gly  Val Ile Ala Asp Asn  Ala Tyr Ser 
        995                 1000                 1005             


Ser Tyr  Ser Leu Ile Val Ser  Trp Gln Lys Ala Ala  Gly Val Ala 
    1010                 1015                 1020             


Glu Arg  Tyr Asp Ile Leu Leu  Leu Thr Glu Asn Gly  Ile Leu Leu 
    1025                 1030                 1035             


Arg Asn  Thr Ser Glu Pro Ala  Thr Thr Lys Gln His  Lys Phe Glu 
    1040                 1045                 1050             


Asp Leu  Thr Pro Gly Lys Lys  Tyr Lys Ile Gln Ile  Leu Thr Val 
    1055                 1060                 1065             


Ser Gly  Gly Leu Phe Ser Lys  Glu Ala Gln Thr Glu  Gly Arg Thr 
    1070                 1075                 1080             


Val Pro  Ala Ala Val Thr Asp  Leu Arg Ile Thr Glu  Asn Ser Thr 
    1085                 1090                 1095             


Arg His  Leu Ser Phe Arg Trp  Thr Ala Ser Glu Gly  Glu Leu Ser 
    1100                 1105                 1110             


Trp Tyr  Asn Ile Phe Leu Tyr  Asn Pro Asp Gly Asn  Leu Gln Glu 
    1115                 1120                 1125             


Arg Ala  Gln Val Asp Pro Leu  Val Gln Ser Phe Ser  Phe Gln Asn 
    1130                 1135                 1140             


Leu Leu  Gln Gly Arg Met Tyr  Lys Met Val Ile Val  Thr His Ser 
    1145                 1150                 1155             


Gly Glu  Leu Ser Asn Glu Ser  Phe Ile Phe Gly Arg  Thr Val Pro 
    1160                 1165                 1170             


Ala Ser  Val Ser His Leu Arg  Gly Ser Asn Arg Asn  Thr Thr Asp 
    1175                 1180                 1185             


Ser Leu  Trp Phe Asn Trp Ser  Pro Ala Ser Gly Asp  Phe Asp Phe 
    1190                 1195                 1200             


Tyr Glu  Leu Ile Leu Tyr Asn  Pro Asn Gly Thr Lys  Lys Glu Asn 
    1205                 1210                 1215             


Trp Lys  Asp Lys Asp Leu Thr  Glu Trp Arg Phe Gln  Gly Leu Val 
    1220                 1225                 1230             


Pro Gly  Arg Lys Tyr Val Leu  Trp Val Val Thr His  Ser Gly Asp 
    1235                 1240                 1245             


Leu Ser  Asn Lys Val Thr Ala  Glu Ser Arg Thr Ala  Pro Ser Pro 
    1250                 1255                 1260             


Pro Ser  Leu Met Ser Phe Ala  Asp Ile Ala Asn Thr  Ser Leu Ala 
    1265                 1270                 1275             


Ile Thr  Trp Lys Gly Pro Pro  Asp Trp Thr Asp Tyr  Asn Asp Phe 
    1280                 1285                 1290             


Glu Leu  Gln Trp Leu Pro Arg  Asp Ala Leu Thr Val  Phe Asn Pro 
    1295                 1300                 1305             


Tyr Asn  Asn Arg Lys Ser Glu  Gly Arg Ile Val Tyr  Gly Leu Arg 
    1310                 1315                 1320             


Pro Gly  Arg Ser Tyr Gln Phe  Asn Val Lys Thr Val  Ser Gly Asp 
    1325                 1330                 1335             


Ser Trp  Lys Thr Tyr Ser Lys  Pro Ile Phe Gly Ser  Val Arg Thr 
    1340                 1345                 1350             


Lys Pro  Asp Lys Ile Gln Asn  Leu His Cys Arg Pro  Gln Asn Ser 
    1355                 1360                 1365             


Thr Ala  Ile Ala Cys Ser Trp  Ile Pro Pro Asp Ser  Asp Phe Asp 
    1370                 1375                 1380             


Gly Tyr  Ser Ile Glu Cys Arg  Lys Met Asp Thr Gln  Glu Val Glu 
    1385                 1390                 1395             


Phe Ser  Arg Lys Leu Glu Lys  Glu Lys Ser Leu Leu  Asn Ile Met 
    1400                 1405                 1410             


Met Leu  Val Pro His Lys Arg  Tyr Leu Val Ser Ile  Lys Val Gln 
    1415                 1420                 1425             


Ser Ala  Gly Met Thr Ser Glu  Val Val Glu Asp Ser  Thr Ile Thr 
    1430                 1435                 1440             


Met Ile  Asp Arg Pro Pro Pro  Pro Pro Pro His Ile  Arg Val Asn 
    1445                 1450                 1455             


Glu Lys  Asp Val Leu Ile Ser  Lys Ser Ser Ile Asn  Phe Thr Val 
    1460                 1465                 1470             


Asn Cys  Ser Trp Phe Ser Asp  Thr Asn Gly Ala Val  Lys Tyr Phe 
    1475                 1480                 1485             


Thr Val  Val Val Arg Glu Ala  Asp Gly Asn Asp Glu  Leu Lys Pro 
    1490                 1495                 1500             


Glu Gln  Gln His Pro Leu Pro  Ser Tyr Leu Glu Tyr  Arg His Asn 
    1505                 1510                 1515             


Ala Ser  Ile Arg Val Tyr Gln  Thr Asn Tyr Phe Ala  Ser Lys Cys 
    1520                 1525                 1530             


Ala Glu  Asn Pro Asn Ser Asn  Ser Lys Ser Phe Asn  Ile Lys Leu 
    1535                 1540                 1545             


Gly Ala  Glu Met Glu Ser Leu  Gly Gly Lys Cys Asp  Pro Thr Gln 
    1550                 1555                 1560             


Gln Lys  Phe Cys Asp Gly Pro  Leu Lys Pro His Thr  Ala Tyr Arg 
    1565                 1570                 1575             


Ile Ser  Ile Arg Ala Phe Thr  Gln Leu Phe Asp Glu  Asp Leu Lys 
    1580                 1585                 1590             


Glu Phe  Thr Lys Pro Leu Tyr  Ser Asp Thr Phe Phe  Ser Leu Pro 
    1595                 1600                 1605             


Ile Thr  Thr Glu Ser Glu Pro  Leu Phe Gly Ala Ile  Glu Gly Val 
    1610                 1615                 1620             


Ser Ala  Gly Leu Phe Leu Ile  Gly Met Leu Val Ala  Val Val Ala 
    1625                 1630                 1635             


Leu Leu  Ile Cys Arg Gln Lys  Val Ser His Gly Arg  Glu Arg Pro 
    1640                 1645                 1650             


Ser Ala  Arg Leu Ser Ile Arg  Arg Asp Arg Pro Leu  Ser Val His 
    1655                 1660                 1665             


Leu Asn  Leu Gly Gln Lys Gly  Asn Arg Lys Thr Ser  Cys Pro Ile 
    1670                 1675                 1680             


Lys Ile  Asn Gln Phe Glu Gly  His Phe Met Lys Leu  Gln Ala Asp 
    1685                 1690                 1695             


Ser Asn  Tyr Leu Leu Ser Lys  Glu Tyr Glu Glu Leu  Lys Asp Val 
    1700                 1705                 1710             


Gly Arg  Asn Gln Ser Cys Asp  Ile Ala Leu Leu Pro  Glu Asn Arg 
    1715                 1720                 1725             


Gly Lys  Asn Arg Tyr Asn Asn  Ile Leu Pro Tyr Asp  Ala Thr Arg 
    1730                 1735                 1740             


Val Lys  Leu Ser Asn Val Asp  Asp Asp Pro Cys Ser  Asp Tyr Ile 
    1745                 1750                 1755             


Asn Ala  Ser Tyr Ile Pro Gly  Asn Asn Phe Arg Arg  Glu Tyr Ile 
    1760                 1765                 1770             


Val Thr  Gln Gly Pro Leu Pro  Gly Thr Lys Asp Asp  Phe Trp Lys 
    1775                 1780                 1785             


Met Val  Trp Glu Gln Asn Val  His Asn Ile Val Met  Val Thr Gln 
    1790                 1795                 1800             


Cys Val  Glu Lys Gly Arg Val  Lys Cys Asp His Tyr  Trp Pro Ala 
    1805                 1810                 1815             


Asp Gln  Asp Ser Leu Tyr Tyr  Gly Asp Leu Ile Leu  Gln Met Leu 
    1820                 1825                 1830             


Ser Glu  Ser Val Leu Pro Glu  Trp Thr Ile Arg Glu  Phe Lys Ile 
    1835                 1840                 1845             


Cys Gly  Glu Glu Gln Leu Asp  Ala His Arg Leu Ile  Arg His Phe 
    1850                 1855                 1860             


His Tyr  Thr Val Trp Pro Asp  His Gly Val Pro Glu  Thr Thr Gln 
    1865                 1870                 1875             


Ser Leu  Ile Gln Phe Val Arg  Thr Val Arg Asp Tyr  Ile Asn Arg 
    1880                 1885                 1890             


Ser Pro  Gly Ala Gly Pro Thr  Val Val His Cys Ser  Ala Gly Val 
    1895                 1900                 1905             


Gly Arg  Thr Gly Thr Phe Ile  Ala Leu Asp Arg Ile  Leu Gln Gln 
    1910                 1915                 1920             


Leu Asp  Ser Lys Asp Ser Val  Asp Ile Tyr Gly Ala  Val His Asp 
    1925                 1930                 1935             


Leu Arg  Leu His Arg Val His  Met Val Gln Thr Glu  Cys Gln Tyr 
    1940                 1945                 1950             


Val Tyr  Leu His Gln Cys Val  Arg Asp Val Leu Arg  Ala Arg Lys 
    1955                 1960                 1965             


Leu Arg  Ser Glu Gln Glu Asn  Pro Leu Phe Pro Ile  Tyr Glu Asn 
    1970                 1975                 1980             


Val Asn  Pro Glu Tyr His Arg  Asp Pro Val Tyr Ser  Arg His 
    1985                 1990                 1995         


<210>  3
<211>  1631
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Leu Ser His Gly Ala Gly Leu Ala Leu Trp Ile Thr Leu Ser Leu 
1               5                   10                  15      


Leu Gln Thr Gly Leu Ala Glu Pro Glu Arg Cys Asn Phe Thr Leu Ala 
            20                  25                  30          


Glu Ser Lys Ala Ser Ser His Ser Val Ser Ile Gln Trp Arg Ile Leu 
        35                  40                  45              


Gly Ser Pro Cys Asn Phe Ser Leu Ile Tyr Ser Ser Asp Thr Leu Gly 
    50                  55                  60                  


Ala Ala Leu Cys Pro Thr Phe Arg Ile Asp Asn Thr Thr Tyr Gly Cys 
65                  70                  75                  80  


Asn Leu Gln Asp Leu Gln Ala Gly Thr Ile Tyr Asn Phe Arg Ile Ile 
                85                  90                  95      


Ser Leu Asp Glu Glu Arg Thr Val Val Leu Gln Thr Asp Pro Leu Pro 
            100                 105                 110         


Pro Ala Arg Phe Gly Val Ser Lys Glu Lys Thr Thr Ser Thr Ser Leu 
        115                 120                 125             


His Val Trp Trp Thr Pro Ser Ser Gly Lys Val Thr Ser Tyr Glu Val 
    130                 135                 140                 


Gln Leu Phe Asp Glu Asn Asn Gln Lys Ile Gln Gly Val Gln Ile Gln 
145                 150                 155                 160 


Glu Ser Thr Ser Trp Asn Glu Tyr Thr Phe Phe Asn Leu Thr Ala Gly 
                165                 170                 175     


Ser Lys Tyr Asn Ile Ala Ile Thr Ala Val Ser Gly Gly Lys Arg Ser 
            180                 185                 190         


Phe Ser Val Tyr Thr Asn Gly Ser Thr Val Pro Ser Pro Val Lys Asp 
        195                 200                 205             


Ile Gly Ile Ser Thr Lys Ala Asn Ser Leu Leu Ile Ser Trp Ser His 
    210                 215                 220                 


Gly Ser Gly Asn Val Glu Arg Tyr Arg Leu Met Leu Met Asp Lys Gly 
225                 230                 235                 240 


Ile Leu Val His Gly Gly Val Val Asp Lys His Ala Thr Ser Tyr Ala 
                245                 250                 255     


Phe His Gly Leu Thr Pro Gly Tyr Leu Tyr Asn Leu Thr Val Met Thr 
            260                 265                 270         


Glu Ala Ala Gly Leu Gln Asn Tyr Arg Trp Lys Leu Val Arg Thr Ala 
        275                 280                 285             


Pro Met Glu Val Ser Asn Leu Lys Val Thr Asn Asp Gly Ser Leu Thr 
    290                 295                 300                 


Ser Leu Lys Val Lys Trp Gln Arg Pro Pro Gly Asn Val Asp Ser Tyr 
305                 310                 315                 320 


Asn Ile Thr Leu Ser His Lys Gly Thr Ile Lys Glu Ser Arg Val Leu 
                325                 330                 335     


Ala Pro Trp Ile Thr Glu Thr His Phe Lys Glu Leu Val Pro Gly Arg 
            340                 345                 350         


Leu Tyr Gln Val Thr Val Ser Cys Val Ser Gly Glu Leu Ser Ala Gln 
        355                 360                 365             


Lys Met Ala Val Gly Arg Thr Phe Pro Asp Lys Val Ala Asn Leu Glu 
    370                 375                 380                 


Ala Asn Asn Asn Gly Arg Met Arg Ser Leu Val Val Ser Trp Ser Pro 
385                 390                 395                 400 


Pro Ala Gly Asp Trp Glu Gln Tyr Arg Ile Leu Leu Phe Asn Asp Ser 
                405                 410                 415     


Val Val Leu Leu Asn Ile Thr Val Gly Lys Glu Glu Thr Gln Tyr Val 
            420                 425                 430         


Met Asp Asp Thr Gly Leu Val Pro Gly Arg Gln Tyr Glu Val Glu Val 
        435                 440                 445             


Ile Val Glu Ser Gly Asn Leu Lys Asn Ser Glu Arg Cys Gln Gly Arg 
    450                 455                 460                 


Thr Val Pro Leu Ala Val Leu Gln Leu Arg Val Lys His Ala Asn Glu 
465                 470                 475                 480 


Thr Ser Leu Ser Ile Met Trp Gln Thr Pro Val Ala Glu Trp Glu Lys 
                485                 490                 495     


Tyr Ile Ile Ser Leu Ala Asp Arg Asp Leu Leu Leu Ile His Lys Ser 
            500                 505                 510         


Leu Ser Lys Asp Ala Lys Glu Phe Thr Phe Thr Asp Leu Val Pro Gly 
        515                 520                 525             


Arg Lys Tyr Met Ala Thr Val Thr Ser Ile Ser Gly Asp Leu Lys Asn 
    530                 535                 540                 


Ser Ser Ser Val Lys Gly Arg Thr Val Pro Ala Gln Val Thr Asp Leu 
545                 550                 555                 560 


His Val Ala Asn Gln Gly Met Thr Ser Ser Leu Phe Thr Asn Trp Thr 
                565                 570                 575     


Gln Ala Gln Gly Asp Val Glu Phe Tyr Gln Val Leu Leu Ile His Glu 
            580                 585                 590         


Asn Val Val Ile Lys Asn Glu Ser Ile Ser Ser Glu Thr Ser Arg Tyr 
        595                 600                 605             


Ser Phe His Ser Leu Lys Ser Gly Ser Leu Tyr Ser Val Val Val Thr 
    610                 615                 620                 


Thr Val Ser Gly Gly Ile Ser Ser Arg Gln Val Val Val Glu Gly Arg 
625                 630                 635                 640 


Thr Val Pro Ser Ser Val Ser Gly Val Thr Val Asn Asn Ser Gly Arg 
                645                 650                 655     


Asn Asp Tyr Leu Ser Val Ser Trp Leu Leu Ala Pro Gly Asp Val Asp 
            660                 665                 670         


Asn Tyr Glu Val Thr Leu Ser His Asp Gly Lys Val Val Gln Ser Leu 
        675                 680                 685             


Val Ile Ala Lys Ser Val Arg Glu Cys Ser Phe Ser Ser Leu Thr Pro 
    690                 695                 700                 


Gly Arg Leu Tyr Thr Val Thr Ile Thr Thr Arg Ser Gly Lys Tyr Glu 
705                 710                 715                 720 


Asn His Ser Phe Ser Gln Glu Arg Thr Val Pro Asp Lys Val Gln Gly 
                725                 730                 735     


Val Ser Val Ser Asn Ser Ala Arg Ser Asp Tyr Leu Arg Val Ser Trp 
            740                 745                 750         


Val His Ala Thr Gly Asp Phe Asp His Tyr Glu Val Thr Ile Lys Asn 
        755                 760                 765             


Lys Asn Asn Phe Ile Gln Thr Lys Ser Ile Pro Lys Ser Glu Asn Glu 
    770                 775                 780                 


Cys Val Phe Val Gln Leu Val Pro Gly Arg Leu Tyr Ser Val Thr Val 
785                 790                 795                 800 


Thr Thr Lys Ser Gly Gln Tyr Glu Ala Asn Glu Gln Gly Asn Gly Arg 
                805                 810                 815     


Thr Ile Pro Glu Pro Val Lys Asp Leu Thr Leu Arg Asn Arg Ser Thr 
            820                 825                 830         


Glu Asp Leu His Val Thr Trp Ser Gly Ala Asn Gly Asp Val Asp Gln 
        835                 840                 845             


Tyr Glu Ile Gln Leu Leu Phe Asn Asp Met Lys Val Phe Pro Pro Phe 
    850                 855                 860                 


His Leu Val Asn Thr Ala Thr Glu Tyr Arg Phe Thr Ser Leu Thr Pro 
865                 870                 875                 880 


Gly Arg Gln Tyr Lys Ile Leu Val Leu Thr Ile Ser Gly Asp Val Gln 
                885                 890                 895     


Gln Ser Ala Phe Ile Glu Gly Phe Thr Val Pro Ser Ala Val Lys Asn 
            900                 905                 910         


Ile His Ile Ser Pro Asn Gly Ala Thr Asp Ser Leu Thr Val Asn Trp 
        915                 920                 925             


Thr Pro Gly Gly Gly Asp Val Asp Ser Tyr Thr Val Ser Ala Phe Arg 
    930                 935                 940                 


His Ser Gln Lys Val Asp Ser Gln Thr Ile Pro Lys His Val Phe Glu 
945                 950                 955                 960 


His Thr Phe His Arg Leu Glu Ala Gly Glu Gln Tyr Gln Ile Met Ile 
                965                 970                 975     


Ala Ser Val Ser Gly Ser Leu Lys Asn Gln Ile Asn Val Val Gly Arg 
            980                 985                 990         


Thr Val Pro Ala Ser Val Gln Gly  Val Ile Ala Asp Asn  Ala Tyr Ser 
        995                 1000                 1005             


Ser Tyr  Ser Leu Ile Val Ser  Trp Gln Lys Ala Ala  Gly Val Ala 
    1010                 1015                 1020             


Glu Arg  Tyr Asp Ile Leu Leu  Leu Thr Glu Asn Gly  Ile Leu Leu 
    1025                 1030                 1035             


Arg Asn  Thr Ser Glu Pro Ala  Thr Thr Lys Gln His  Lys Phe Glu 
    1040                 1045                 1050             


Asp Leu  Thr Pro Gly Lys Lys  Tyr Lys Ile Gln Ile  Leu Thr Val 
    1055                 1060                 1065             


Ser Gly  Gly Leu Phe Ser Lys  Glu Ala Gln Thr Glu  Gly Arg Thr 
    1070                 1075                 1080             


Val Pro  Ala Ala Val Thr Asp  Leu Arg Ile Thr Glu  Asn Ser Thr 
    1085                 1090                 1095             


Arg His  Leu Ser Phe Arg Trp  Thr Ala Ser Glu Gly  Glu Leu Ser 
    1100                 1105                 1110             


Trp Tyr  Asn Ile Phe Leu Tyr  Asn Pro Asp Gly Asn  Leu Gln Glu 
    1115                 1120                 1125             


Arg Ala  Gln Val Asp Pro Leu  Val Gln Ser Phe Ser  Phe Gln Asn 
    1130                 1135                 1140             


Leu Leu  Gln Gly Arg Met Tyr  Lys Met Val Ile Val  Thr His Ser 
    1145                 1150                 1155             


Gly Glu  Leu Ser Asn Glu Ser  Phe Ile Phe Gly Arg  Thr Val Pro 
    1160                 1165                 1170             


Ala Ser  Val Ser His Leu Arg  Gly Ser Asn Arg Asn  Thr Thr Asp 
    1175                 1180                 1185             


Ser Leu  Trp Phe Asn Trp Ser  Pro Ala Ser Gly Asp  Phe Asp Phe 
    1190                 1195                 1200             


Tyr Glu  Leu Ile Leu Tyr Asn  Pro Asn Gly Thr Lys  Lys Glu Asn 
    1205                 1210                 1215             


Trp Lys  Asp Lys Asp Leu Thr  Glu Trp Arg Phe Gln  Gly Leu Val 
    1220                 1225                 1230             


Pro Gly  Arg Lys Tyr Val Leu  Trp Val Val Thr His  Ser Gly Asp 
    1235                 1240                 1245             


Leu Ser  Asn Lys Val Thr Ala  Glu Ser Arg Thr Ala  Pro Ser Pro 
    1250                 1255                 1260             


Pro Ser  Leu Met Ser Phe Ala  Asp Ile Ala Asn Thr  Ser Leu Ala 
    1265                 1270                 1275             


Ile Thr  Trp Lys Gly Pro Pro  Asp Trp Thr Asp Tyr  Asn Asp Phe 
    1280                 1285                 1290             


Glu Leu  Gln Trp Leu Pro Arg  Asp Ala Leu Thr Val  Phe Asn Pro 
    1295                 1300                 1305             


Tyr Asn  Asn Arg Lys Ser Glu  Gly Arg Ile Val Tyr  Gly Leu Arg 
    1310                 1315                 1320             


Pro Gly  Arg Ser Tyr Gln Phe  Asn Val Lys Thr Val  Ser Gly Asp 
    1325                 1330                 1335             


Ser Trp  Lys Thr Tyr Ser Lys  Pro Ile Phe Gly Ser  Val Arg Thr 
    1340                 1345                 1350             


Lys Pro  Asp Lys Ile Gln Asn  Leu His Cys Arg Pro  Gln Asn Ser 
    1355                 1360                 1365             


Thr Ala  Ile Ala Cys Ser Trp  Ile Pro Pro Asp Ser  Asp Phe Asp 
    1370                 1375                 1380             


Gly Tyr  Ser Ile Glu Cys Arg  Lys Met Asp Thr Gln  Glu Val Glu 
    1385                 1390                 1395             


Phe Ser  Arg Lys Leu Glu Lys  Glu Lys Ser Leu Leu  Asn Ile Met 
    1400                 1405                 1410             


Met Leu  Val Pro His Lys Arg  Tyr Leu Val Ser Ile  Lys Val Gln 
    1415                 1420                 1425             


Ser Ala  Gly Met Thr Ser Glu  Val Val Glu Asp Ser  Thr Ile Thr 
    1430                 1435                 1440             


Met Ile  Asp Arg Pro Pro Pro  Pro Pro Pro His Ile  Arg Val Asn 
    1445                 1450                 1455             


Glu Lys  Asp Val Leu Ile Ser  Lys Ser Ser Ile Asn  Phe Thr Val 
    1460                 1465                 1470             


Asn Cys  Ser Trp Phe Ser Asp  Thr Asn Gly Ala Val  Lys Tyr Phe 
    1475                 1480                 1485             


Thr Val  Val Val Arg Glu Ala  Asp Gly Asn Asp Glu  Leu Lys Pro 
    1490                 1495                 1500             


Glu Gln  Gln His Pro Leu Pro  Ser Tyr Leu Glu Tyr  Arg His Asn 
    1505                 1510                 1515             


Ala Ser  Ile Arg Val Tyr Gln  Thr Asn Tyr Phe Ala  Ser Lys Cys 
    1520                 1525                 1530             


Ala Glu  Asn Pro Asn Ser Asn  Ser Lys Ser Phe Asn  Ile Lys Leu 
    1535                 1540                 1545             


Gly Ala  Glu Met Glu Ser Leu  Gly Gly Lys Cys Asp  Pro Thr Gln 
    1550                 1555                 1560             


Gln Lys  Phe Cys Asp Gly Pro  Leu Lys Pro His Thr  Ala Tyr Arg 
    1565                 1570                 1575             


Ile Ser  Ile Arg Ala Phe Thr  Gln Leu Phe Asp Glu  Asp Leu Lys 
    1580                 1585                 1590             


Glu Phe  Thr Lys Pro Leu Tyr  Ser Asp Thr Phe Phe  Ser Leu Pro 
    1595                 1600                 1605             


Ile Thr  Thr Glu Ser Glu Pro  Leu Phe Gly Ala Ile  Glu Arg Gly 
    1610                 1615                 1620             


Arg His  His His His His His  Gly 
    1625                 1630     


<210>  4
<211>  1621
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Leu Ser His Gly Ala Gly Leu Ala Leu Trp Ile Thr Leu Ser Leu 
1               5                   10                  15      


Leu Gln Thr Gly Leu Ala Glu Pro Glu Arg Cys Asn Phe Thr Leu Ala 
            20                  25                  30          


Glu Ser Lys Ala Ser Ser His Ser Val Ser Ile Gln Trp Arg Ile Leu 
        35                  40                  45              


Gly Ser Pro Cys Asn Phe Ser Leu Ile Tyr Ser Ser Asp Thr Leu Gly 
    50                  55                  60                  


Ala Ala Leu Cys Pro Thr Phe Arg Ile Asp Asn Thr Thr Tyr Gly Cys 
65                  70                  75                  80  


Asn Leu Gln Asp Leu Gln Ala Gly Thr Ile Tyr Asn Phe Arg Ile Ile 
                85                  90                  95      


Ser Leu Asp Glu Glu Arg Thr Val Val Leu Gln Thr Asp Pro Leu Pro 
            100                 105                 110         


Pro Ala Arg Phe Gly Val Ser Lys Glu Lys Thr Thr Ser Thr Ser Leu 
        115                 120                 125             


His Val Trp Trp Thr Pro Ser Ser Gly Lys Val Thr Ser Tyr Glu Val 
    130                 135                 140                 


Gln Leu Phe Asp Glu Asn Asn Gln Lys Ile Gln Gly Val Gln Ile Gln 
145                 150                 155                 160 


Glu Ser Thr Ser Trp Asn Glu Tyr Thr Phe Phe Asn Leu Thr Ala Gly 
                165                 170                 175     


Ser Lys Tyr Asn Ile Ala Ile Thr Ala Val Ser Gly Gly Lys Arg Ser 
            180                 185                 190         


Phe Ser Val Tyr Thr Asn Gly Ser Thr Val Pro Ser Pro Val Lys Asp 
        195                 200                 205             


Ile Gly Ile Ser Thr Lys Ala Asn Ser Leu Leu Ile Ser Trp Ser His 
    210                 215                 220                 


Gly Ser Gly Asn Val Glu Arg Tyr Arg Leu Met Leu Met Asp Lys Gly 
225                 230                 235                 240 


Ile Leu Val His Gly Gly Val Val Asp Lys His Ala Thr Ser Tyr Ala 
                245                 250                 255     


Phe His Gly Leu Thr Pro Gly Tyr Leu Tyr Asn Leu Thr Val Met Thr 
            260                 265                 270         


Glu Ala Ala Gly Leu Gln Asn Tyr Arg Trp Lys Leu Val Arg Thr Ala 
        275                 280                 285             


Pro Met Glu Val Ser Asn Leu Lys Val Thr Asn Asp Gly Ser Leu Thr 
    290                 295                 300                 


Ser Leu Lys Val Lys Trp Gln Arg Pro Pro Gly Asn Val Asp Ser Tyr 
305                 310                 315                 320 


Asn Ile Thr Leu Ser His Lys Gly Thr Ile Lys Glu Ser Arg Val Leu 
                325                 330                 335     


Ala Pro Trp Ile Thr Glu Thr His Phe Lys Glu Leu Val Pro Gly Arg 
            340                 345                 350         


Leu Tyr Gln Val Thr Val Ser Cys Val Ser Gly Glu Leu Ser Ala Gln 
        355                 360                 365             


Lys Met Ala Val Gly Arg Thr Phe Pro Asp Lys Val Ala Asn Leu Glu 
    370                 375                 380                 


Ala Asn Asn Asn Gly Arg Met Arg Ser Leu Val Val Ser Trp Ser Pro 
385                 390                 395                 400 


Pro Ala Gly Asp Trp Glu Gln Tyr Arg Ile Leu Leu Phe Asn Asp Ser 
                405                 410                 415     


Val Val Leu Leu Asn Ile Thr Val Gly Lys Glu Glu Thr Gln Tyr Val 
            420                 425                 430         


Met Asp Asp Thr Gly Leu Val Pro Gly Arg Gln Tyr Glu Val Glu Val 
        435                 440                 445             


Ile Val Glu Ser Gly Asn Leu Lys Asn Ser Glu Arg Cys Gln Gly Arg 
    450                 455                 460                 


Thr Val Pro Leu Ala Val Leu Gln Leu Arg Val Lys His Ala Asn Glu 
465                 470                 475                 480 


Thr Ser Leu Ser Ile Met Trp Gln Thr Pro Val Ala Glu Trp Glu Lys 
                485                 490                 495     


Tyr Ile Ile Ser Leu Ala Asp Arg Asp Leu Leu Leu Ile His Lys Ser 
            500                 505                 510         


Leu Ser Lys Asp Ala Lys Glu Phe Thr Phe Thr Asp Leu Val Pro Gly 
        515                 520                 525             


Arg Lys Tyr Met Ala Thr Val Thr Ser Ile Ser Gly Asp Leu Lys Asn 
    530                 535                 540                 


Ser Ser Ser Val Lys Gly Arg Thr Val Pro Ala Gln Val Thr Asp Leu 
545                 550                 555                 560 


His Val Ala Asn Gln Gly Met Thr Ser Ser Leu Phe Thr Asn Trp Thr 
                565                 570                 575     


Gln Ala Gln Gly Asp Val Glu Phe Tyr Gln Val Leu Leu Ile His Glu 
            580                 585                 590         


Asn Val Val Ile Lys Asn Glu Ser Ile Ser Ser Glu Thr Ser Arg Tyr 
        595                 600                 605             


Ser Phe His Ser Leu Lys Ser Gly Ser Leu Tyr Ser Val Val Val Thr 
    610                 615                 620                 


Thr Val Ser Gly Gly Ile Ser Ser Arg Gln Val Val Val Glu Gly Arg 
625                 630                 635                 640 


Thr Val Pro Ser Ser Val Ser Gly Val Thr Val Asn Asn Ser Gly Arg 
                645                 650                 655     


Asn Asp Tyr Leu Ser Val Ser Trp Leu Leu Ala Pro Gly Asp Val Asp 
            660                 665                 670         


Asn Tyr Glu Val Thr Leu Ser His Asp Gly Lys Val Val Gln Ser Leu 
        675                 680                 685             


Val Ile Ala Lys Ser Val Arg Glu Cys Ser Phe Ser Ser Leu Thr Pro 
    690                 695                 700                 


Gly Arg Leu Tyr Thr Val Thr Ile Thr Thr Arg Ser Gly Lys Tyr Glu 
705                 710                 715                 720 


Asn His Ser Phe Ser Gln Glu Arg Thr Val Pro Asp Lys Val Gln Gly 
                725                 730                 735     


Val Ser Val Ser Asn Ser Ala Arg Ser Asp Tyr Leu Arg Val Ser Trp 
            740                 745                 750         


Val His Ala Thr Gly Asp Phe Asp His Tyr Glu Val Thr Ile Lys Asn 
        755                 760                 765             


Lys Asn Asn Phe Ile Gln Thr Lys Ser Ile Pro Lys Ser Glu Asn Glu 
    770                 775                 780                 


Cys Val Phe Val Gln Leu Val Pro Gly Arg Leu Tyr Ser Val Thr Val 
785                 790                 795                 800 


Thr Thr Lys Ser Gly Gln Tyr Glu Ala Asn Glu Gln Gly Asn Gly Arg 
                805                 810                 815     


Thr Ile Pro Glu Pro Val Lys Asp Leu Thr Leu Arg Asn Arg Ser Thr 
            820                 825                 830         


Glu Asp Leu His Val Thr Trp Ser Gly Ala Asn Gly Asp Val Asp Gln 
        835                 840                 845             


Tyr Glu Ile Gln Leu Leu Phe Asn Asp Met Lys Val Phe Pro Pro Phe 
    850                 855                 860                 


His Leu Val Asn Thr Ala Thr Glu Tyr Arg Phe Thr Ser Leu Thr Pro 
865                 870                 875                 880 


Gly Arg Gln Tyr Lys Ile Leu Val Leu Thr Ile Ser Gly Asp Val Gln 
                885                 890                 895     


Gln Ser Ala Phe Ile Glu Gly Phe Thr Val Pro Ser Ala Val Lys Asn 
            900                 905                 910         


Ile His Ile Ser Pro Asn Gly Ala Thr Asp Ser Leu Thr Val Asn Trp 
        915                 920                 925             


Thr Pro Gly Gly Gly Asp Val Asp Ser Tyr Thr Val Ser Ala Phe Arg 
    930                 935                 940                 


His Ser Gln Lys Val Asp Ser Gln Thr Ile Pro Lys His Val Phe Glu 
945                 950                 955                 960 


His Thr Phe His Arg Leu Glu Ala Gly Glu Gln Tyr Gln Ile Met Ile 
                965                 970                 975     


Ala Ser Val Ser Gly Ser Leu Lys Asn Gln Ile Asn Val Val Gly Arg 
            980                 985                 990         


Thr Val Pro Ala Ser Val Gln Gly  Val Ile Ala Asp Asn  Ala Tyr Ser 
        995                 1000                 1005             


Ser Tyr  Ser Leu Ile Val Ser  Trp Gln Lys Ala Ala  Gly Val Ala 
    1010                 1015                 1020             


Glu Arg  Tyr Asp Ile Leu Leu  Leu Thr Glu Asn Gly  Ile Leu Leu 
    1025                 1030                 1035             


Arg Asn  Thr Ser Glu Pro Ala  Thr Thr Lys Gln His  Lys Phe Glu 
    1040                 1045                 1050             


Asp Leu  Thr Pro Gly Lys Lys  Tyr Lys Ile Gln Ile  Leu Thr Val 
    1055                 1060                 1065             


Ser Gly  Gly Leu Phe Ser Lys  Glu Ala Gln Thr Glu  Gly Arg Thr 
    1070                 1075                 1080             


Val Pro  Ala Ala Val Thr Asp  Leu Arg Ile Thr Glu  Asn Ser Thr 
    1085                 1090                 1095             


Arg His  Leu Ser Phe Arg Trp  Thr Ala Ser Glu Gly  Glu Leu Ser 
    1100                 1105                 1110             


Trp Tyr  Asn Ile Phe Leu Tyr  Asn Pro Asp Gly Asn  Leu Gln Glu 
    1115                 1120                 1125             


Arg Ala  Gln Val Asp Pro Leu  Val Gln Ser Phe Ser  Phe Gln Asn 
    1130                 1135                 1140             


Leu Leu  Gln Gly Arg Met Tyr  Lys Met Val Ile Val  Thr His Ser 
    1145                 1150                 1155             


Gly Glu  Leu Ser Asn Glu Ser  Phe Ile Phe Gly Arg  Thr Val Pro 
    1160                 1165                 1170             


Ala Ser  Val Ser His Leu Arg  Gly Ser Asn Arg Asn  Thr Thr Asp 
    1175                 1180                 1185             


Ser Leu  Trp Phe Asn Trp Ser  Pro Ala Ser Gly Asp  Phe Asp Phe 
    1190                 1195                 1200             


Tyr Glu  Leu Ile Leu Tyr Asn  Pro Asn Gly Thr Lys  Lys Glu Asn 
    1205                 1210                 1215             


Trp Lys  Asp Lys Asp Leu Thr  Glu Trp Arg Phe Gln  Gly Leu Val 
    1220                 1225                 1230             


Pro Gly  Arg Lys Tyr Val Leu  Trp Val Val Thr His  Ser Gly Asp 
    1235                 1240                 1245             


Leu Ser  Asn Lys Val Thr Ala  Glu Ser Arg Thr Ala  Pro Ser Pro 
    1250                 1255                 1260             


Pro Ser  Leu Met Ser Phe Ala  Asp Ile Ala Asn Thr  Ser Leu Ala 
    1265                 1270                 1275             


Ile Thr  Trp Lys Gly Pro Pro  Asp Trp Thr Asp Tyr  Asn Asp Phe 
    1280                 1285                 1290             


Glu Leu  Gln Trp Leu Pro Arg  Asp Ala Leu Thr Val  Phe Asn Pro 
    1295                 1300                 1305             


Tyr Asn  Asn Arg Lys Ser Glu  Gly Arg Ile Val Tyr  Gly Leu Arg 
    1310                 1315                 1320             


Pro Gly  Arg Ser Tyr Gln Phe  Asn Val Lys Thr Val  Ser Gly Asp 
    1325                 1330                 1335             


Ser Trp  Lys Thr Tyr Ser Lys  Pro Ile Phe Gly Ser  Val Arg Thr 
    1340                 1345                 1350             


Lys Pro  Asp Lys Ile Gln Asn  Leu His Cys Arg Pro  Gln Asn Ser 
    1355                 1360                 1365             


Thr Ala  Ile Ala Cys Ser Trp  Ile Pro Pro Asp Ser  Asp Phe Asp 
    1370                 1375                 1380             


Gly Tyr  Ser Ile Glu Cys Arg  Lys Met Asp Thr Gln  Glu Val Glu 
    1385                 1390                 1395             


Phe Ser  Arg Lys Leu Glu Lys  Glu Lys Ser Leu Leu  Asn Ile Met 
    1400                 1405                 1410             


Met Leu  Val Pro His Lys Arg  Tyr Leu Val Ser Ile  Lys Val Gln 
    1415                 1420                 1425             


Ser Ala  Gly Met Thr Ser Glu  Val Val Glu Asp Ser  Thr Ile Thr 
    1430                 1435                 1440             


Met Ile  Asp Arg Pro Pro Pro  Pro Pro Pro His Ile  Arg Val Asn 
    1445                 1450                 1455             


Glu Lys  Asp Val Leu Ile Ser  Lys Ser Ser Ile Asn  Phe Thr Val 
    1460                 1465                 1470             


Asn Cys  Ser Trp Phe Ser Asp  Thr Asn Gly Ala Val  Lys Tyr Phe 
    1475                 1480                 1485             


Thr Val  Val Val Arg Glu Ala  Asp Gly Asn Asp Glu  Leu Lys Pro 
    1490                 1495                 1500             


Glu Gln  Gln His Pro Leu Pro  Ser Tyr Leu Glu Tyr  Arg His Asn 
    1505                 1510                 1515             


Ala Ser  Ile Arg Val Tyr Gln  Thr Asn Tyr Phe Ala  Ser Lys Cys 
    1520                 1525                 1530             


Ala Glu  Asn Pro Asn Ser Asn  Ser Lys Ser Phe Asn  Ile Lys Leu 
    1535                 1540                 1545             


Gly Ala  Glu Met Glu Ser Leu  Gly Gly Lys Cys Asp  Pro Thr Gln 
    1550                 1555                 1560             


Gln Lys  Phe Cys Asp Gly Pro  Leu Lys Pro His Thr  Ala Tyr Arg 
    1565                 1570                 1575             


Ile Ser  Ile Arg Ala Phe Thr  Gln Leu Phe Asp Glu  Asp Leu Lys 
    1580                 1585                 1590             


Glu Phe  Thr Lys Pro Leu Tyr  Ser Asp Thr Phe Phe  Ser Leu Pro 
    1595                 1600                 1605             


Ile Thr  Thr Glu Ser Glu Pro  Leu Phe Gly Ala Ile  Glu 
    1610                 1615                 1620     


<210>  5
<211>  6199
<212>  DNA
<213>  Mus musculus

<400>  5
ggcacgaggg cggctgccac ggcccttgag catcgccagc cccgagggta gcgcgctgcg       60

cccgcccgca gggcgcgctg agcgctcaac aagtggtacc cagaagtgcc ctggctggcc      120

tcccagcgag atgctgaggc atggagccct aacggccttg tggataacac tgagcgtcgt      180

gcagactgga gtggcagagc aagtgaaatg taacttcaca ctgttggagt ccagggtctc      240

tagcttgtca gcgtctatcc agtggaggac tttcgcgtca ccctgtaact ttagcctcat      300

ctacagcagt gatacctcgg ggcccatgtg gtgccatcct attcggatag acaactttac      360

ctacggatgt aaccccaagg atttacaagc agggaccgtc tataacttca ggattgtttc      420

tctggatgga gaagagagca ctctggtctt acagacagat ccgttgcctc ctgccaggtt      480

tgaagtcaat cgggagaaaa cagcatcaac caccctgcag gtccggtgga ctccctcttc      540

tggaaaagtc tcctggtatg aggtgcaatt atttgatcat aacaatcaaa agatacaaga      600

agtccaagtt caagaaagta ccacctggag ccaatatact tttctgaacc tcactgaggg      660

taacagttac aaagttgcca tcacagctgt ttcgggagaa aagcgctcct ttccggtgta      720

tatcaatggc tctacagtac catctccagt gaaagatctt ggcatttccc ccaatcctaa      780

ttctctccta atttcctggt ctcgtggttc tgggaatgtg gaacaataca ggctggtgct      840

aatggataaa ggggccatcg ttcaagacac aaacgtggac aggcgtgata cttcttatgc      900

ttttcacgag ctgacccctg gccacctcta caacctcact attgtcacca tggcctcggg      960

actgcaaaac tccaggtgga aactggtgag gaccgctccc atggaagtct caaatctgaa     1020

ggtgacaaat gacgggaggt tgacctctct aaatgtgaag tggcagaaac cccctgggga     1080

tgtagattcc tacagcatta ccctgtctca ccaagggacc atcaaagaat ccaaaacatt     1140

agcacctcct gttactgaaa ctcaatttaa ggacttagtc cctggacggc tttaccaagt     1200

gaccatcagc tgcatctctg gtgagctctc tgctgagaag tcagcagcgg ggagaacagt     1260

tccagaaaaa gtgaggaatc tggtttccta caacgagatt tggatgaagt cctttacagt     1320

gaactggacg ccccctgctg gagattggga gcattatcgt atcgtgctct tcaatgaatc     1380

cttggtcttg ctcaacacca cagtgggaaa ggaagaaacg cactatgcct tggatggctt     1440

ggagctcata ccaggaagac agtatgagat agaagtcatt gttgagagcg gaaatctgcg     1500

gaattccgag cgctgtcaag gcaggacagt acccctggct gtcctccagc ttcgcgtcaa     1560

acacgctaac gaaacttcac tgggcatcac gtggcgggcc cctctaggcg aatgggagaa     1620

atacatcatt tcgttgatgg acagagagct cttggtcatc cacaagtcac tctccaaaga     1680

tgccaaagaa ttcactttta cagacctgat gcctggacgg aattacaagg ctactgtcac     1740

tagcatgagt ggagatttaa aacagtcatc ttcaatcaaa ggaagaacag tgcctgccca     1800

ggtgactgac ctgcacgtca acaaccaagg gatgaccagt agtctgttca ctaactggac     1860

aaaggcactg ggagatgtag agttctacca agttttactg atccatgaaa atgtggttgt     1920

caagaacgag agtgtttcca gtgataccag cagatacagc ttccgcgccc tgaaacccgg     1980

cagcctctac tccgtggtgg tgaccacggt gagtggaggg atctcctccc ggcaggtggt     2040

ggcggaagga agaacagtcc cgtccagcgt gagtggggtg acagtcaaca attctggccg     2100

gaatgactac ctcagcgttt cctggctgcc ggcgcctgga gaagtggatc actacgtggt     2160

gagcctctcc cacgagggca aggtggatca gttcctcatc atcgccaaat ctgtcagcga     2220

gtgttccttc agctccctca ccccgggccg cctctacaac gtcactgtaa ccaccaagag     2280

cggcaattat gcaagccact ccttcaccga ggaacggaca gtgccagaca aggtccaggg     2340

aatcagtgtt agcaactctg ccagaagcga ctacttaaag gtgtcctggg tgcatgccac     2400

tggagacttt gaccactatg aagtcaccat caaaaacaga gaaagcttca ttcaaaccaa     2460

aaccatcccc aagtcagaaa atgagtgtga atttattgag ctggttcctg gacgcctgta     2520

cagcgtcact gtcagtacaa agagtggaca atatgaagcc agtgaacagg ggacagggag     2580

aacgatccca gagcctgtga aggatctcac ccttctcaac aggagtacgg aggatctcca     2640

tgtgacttgg tcaagagcca atggggatgt tgatcagtac gaggtccagc tgctcttcaa     2700

cgacatgaaa gtcttccctc atattcacct tgtgaacaca gcaactgagt ataagttcac     2760

ggcgctcacg ccggggcgcc attacaaaat cctcgtcctg accatcagtg gcgatgtcca     2820

gcagtcagcc ttcattgaag gcctcccagt tcccagcact gtcaaaaaca ttcacatttc     2880

tgccaatgga gccacggata ggctgatggt aacctggagc cctggtggcg gggatgtgga     2940

ctcctatgtg gtgtctgcat tcagacagga cgagaaggtt gactctcaga ccattcccaa     3000

gcatgcctcg gagcacacgt tccacaggct ggaggccgga gccaagtaca ggatcgccat     3060

tgtttctgtc agtgggtccc tgagaaacca gatagatgcg ctcggacaga cagtcccagc     3120

gtctgtccag ggagtcgtcg cagccaatgc atacagcagt aattccttaa cagtaagttg     3180

gcagaaagcc cttggtgtgg cagaaagata cgatatcctg cttctaaacg agaatgggct     3240

tcttttgagc aacgtgtcag agccagctac ggcaagacag cacaaatttg aagatctaac     3300

gccaggcaag aaatacaaga tgcagatcct gactgtcagc ggaggcctct tcagtaaaga     3360

atctcaggct gaaggccgaa cagtcccagc agctgtcacc aatctgagga tcacagagaa     3420

ctccagtaga tacctgtcct tcggctggac cgcctcggag ggtgaactca gctggtacaa     3480

catcttcctc tacaacccag acaggactct tcaggagcga gctcaagttg acccgctagt     3540

ccagagcttc tctttccaga acttgctaca aggcagaatg tacaagatgg tgattgtcac     3600

tcacagtggg gagctgtcca atgagtcatt tatattcggc agaacagttc ctgctgccgt     3660

gaaccatctc aaaggctccc atcggaacac gacagacagc ctgtggttca gctggagccc     3720

agcctccggg gactttgact tctatgagct gattctttac aatcccaacg gcacgaagaa     3780

ggagaactgg aaagaaaagg acgtgacaga gtggcgtttc caaggtcttg ttcctggaag     3840

gaaatacacc ctgtatgtgg tgactcacag tggggacctc agcaataaag tcacagggga     3900

gggcagaaca gccccaagtc ctccgagtct tttgtcattc gctgatgttg caaacacctc     3960

cttggctatc acctggaagg gacccccaga ctggacagat tacaatgact ttgagctgca     4020

gtggttccct ggagatgcac ttaccatctt caacccctac agcagcagaa agtcagaagg     4080

acgcattgtg tacgggcttc acccagggag gtcctatcaa ttcagtgtca agactgtgag     4140

cggggactcc tggaaaacct acagcaaacc aatttctggg tctgtgagga caaagccaga     4200

caagatacaa aacctgcatt gccgccccca gaactccacg gccattgcct gctcttggat     4260

acctcctgac tccgactttg atggctacag cattgagtgc cgaaaaatgg atacccaaga     4320

aatcgagttt tccagaaagc tggagaaaga aaaatcactg ctcaacatca tgatgttagt     4380

acctcataag aggtacctgg tgtccatcaa ggtgcagtcg gccggcatga ccagtgaggt     4440

ggttgaagat agcaccatca ccatgataga ccgcccgcct caaccgcctc cacacatccg     4500

tgtgaatgaa aaggatgtgc taatcagcaa atcttccatc aactttactg tcaactgcag     4560

ctggttcagc gacaccaacg gagcggttaa atactttgct gtggtggtga gagaggccga     4620

cagcatggat gagttgaagc cagaacagca gcaccctctc ccttcctacc tggagtacag     4680

acacaacgcc tccatccgag tctaccagac caattatttt gccagcaaat gtgctgaaag     4740

tcccgacagc agttctaaaa gtttcaacat taagcttgga gcagagatgg acagcctcgg     4800

tggcaaatgt gatcccagtc agcagaaatt ctgtgatgga ccgctgaagc cacacaccgc     4860

ctacagaatc agcatccggg cttttacaca gctatttgac gaggacttga aagagttcac     4920

caaacctctc tactcggata cgttcttctc tatgcccatc accacagagt cagagccctt     4980

gtttggagtt attgaaggtg tgagtgctgg cctgtttcta attggcatgc tggtggccct     5040

tgttgccttc ttcatctgca gacagaaagc tagccacagc agggaaaggc catctgcccg     5100

gctcagcatt cgtagggacc ggcctttgtc tgtccatctg aatctgggcc agaaaggcaa     5160

ccggaaaact tcttgcccca taaagatcaa tcagtttgaa gggcatttca tgaagctgca     5220

ggcagactcc aactaccttc tatccaagga atatgaggac ttaaaagacg tgggtagaag     5280

ccagtcatgt gacattgccc tcttgcctga gaatcgaggg aaaaatcgat acaacaacat     5340

attgccttat gatgcctcaa gagtgaagct ctcgaatgtc gatgacgacc cttgctctga     5400

ctacatcaac gccagctaca tccccggtaa caacttcaga cgagaataca tcgccactca     5460

gggaccgctt ccaggcacca aggatgactt ctggaagatg gcgtgggagc agaacgttca     5520

caacatcgtc atggtgaccc agtgtgttga aaagggccga gtgaagtgtg accattactg     5580

gccagcagac caggaccccc tctactacgg tgatctcatc ctacagatgg tctcggagtc     5640

cgtgctcccc gagtggacca tcagggagtt taagatatgc agtgaagaac agttggatgc     5700

acacagactc atccgtcact ttcactacac ggtgtggcca gaccatgggg tcccagagac     5760

cacccagtcc ctgatccaat ttgtgaggac agtcagggac tacatcaaca gaagccccgg     5820

ggctgggccc accgtagtgc actgcagcgc tggtgtgggc agaacaggga cgttcgttgc     5880

cctggaccgg atcctccagc agttggactc taaggactcc gtggacattt atggggcagt     5940

gcatgaccta agactccaca gggttcacat ggtccagacc gagtgtcaat atgtgtatct     6000

gcatcagtgt gtaagagacg tcctcagagc aaagaaactg cggaacgagc aagagaaccc     6060

cctgtttccg atttatgaga atgtgaatcc agagtatcac agagatgcaa tctactcgag     6120

acattaagaa ttcacctgaa gatcccctgg ataaaagcgt ttcactgtgt gactttaaaa     6180

aaaaaaaaaa aaaaaaaaa                                                  6199


<210>  6
<211>  1998
<212>  PRT
<213>  Mus musculus

<400>  6

Met Leu Arg His Gly Ala Leu Thr Ala Leu Trp Ile Thr Leu Ser Val 
1               5                   10                  15      


Val Gln Thr Gly Val Ala Glu Gln Val Lys Cys Asn Phe Thr Leu Leu 
            20                  25                  30          


Glu Ser Arg Val Ser Ser Leu Ser Ala Ser Ile Gln Trp Arg Thr Phe 
        35                  40                  45              


Ala Ser Pro Cys Asn Phe Ser Leu Ile Tyr Ser Ser Asp Thr Ser Gly 
    50                  55                  60                  


Pro Met Trp Cys His Pro Ile Arg Ile Asp Asn Phe Thr Tyr Gly Cys 
65                  70                  75                  80  


Asn Pro Lys Asp Leu Gln Ala Gly Thr Val Tyr Asn Phe Arg Ile Val 
                85                  90                  95      


Ser Leu Asp Gly Glu Glu Ser Thr Leu Val Leu Gln Thr Asp Pro Leu 
            100                 105                 110         


Pro Pro Ala Arg Phe Glu Val Asn Arg Glu Lys Thr Ala Ser Thr Thr 
        115                 120                 125             


Leu Gln Val Arg Trp Thr Pro Ser Ser Gly Lys Val Ser Trp Tyr Glu 
    130                 135                 140                 


Val Gln Leu Phe Asp His Asn Asn Gln Lys Ile Gln Glu Val Gln Val 
145                 150                 155                 160 


Gln Glu Ser Thr Thr Trp Ser Gln Tyr Thr Phe Leu Asn Leu Thr Glu 
                165                 170                 175     


Gly Asn Ser Tyr Lys Val Ala Ile Thr Ala Val Ser Gly Glu Lys Arg 
            180                 185                 190         


Ser Phe Pro Val Tyr Ile Asn Gly Ser Thr Val Pro Ser Pro Val Lys 
        195                 200                 205             


Asp Leu Gly Ile Ser Pro Asn Pro Asn Ser Leu Leu Ile Ser Trp Ser 
    210                 215                 220                 


Arg Gly Ser Gly Asn Val Glu Gln Tyr Arg Leu Val Leu Met Asp Lys 
225                 230                 235                 240 


Gly Ala Ile Val Gln Asp Thr Asn Val Asp Arg Arg Asp Thr Ser Tyr 
                245                 250                 255     


Ala Phe His Glu Leu Thr Pro Gly His Leu Tyr Asn Leu Thr Ile Val 
            260                 265                 270         


Thr Met Ala Ser Gly Leu Gln Asn Ser Arg Trp Lys Leu Val Arg Thr 
        275                 280                 285             


Ala Pro Met Glu Val Ser Asn Leu Lys Val Thr Asn Asp Gly Arg Leu 
    290                 295                 300                 


Thr Ser Leu Asn Val Lys Trp Gln Lys Pro Pro Gly Asp Val Asp Ser 
305                 310                 315                 320 


Tyr Ser Ile Thr Leu Ser His Gln Gly Thr Ile Lys Glu Ser Lys Thr 
                325                 330                 335     


Leu Ala Pro Pro Val Thr Glu Thr Gln Phe Lys Asp Leu Val Pro Gly 
            340                 345                 350         


Arg Leu Tyr Gln Val Thr Ile Ser Cys Ile Ser Gly Glu Leu Ser Ala 
        355                 360                 365             


Glu Lys Ser Ala Ala Gly Arg Thr Val Pro Glu Lys Val Arg Asn Leu 
    370                 375                 380                 


Val Ser Tyr Asn Glu Ile Trp Met Lys Ser Phe Thr Val Asn Trp Thr 
385                 390                 395                 400 


Pro Pro Ala Gly Asp Trp Glu His Tyr Arg Ile Val Leu Phe Asn Glu 
                405                 410                 415     


Ser Leu Val Leu Leu Asn Thr Thr Val Gly Lys Glu Glu Thr His Tyr 
            420                 425                 430         


Ala Leu Asp Gly Leu Glu Leu Ile Pro Gly Arg Gln Tyr Glu Ile Glu 
        435                 440                 445             


Val Ile Val Glu Ser Gly Asn Leu Arg Asn Ser Glu Arg Cys Gln Gly 
    450                 455                 460                 


Arg Thr Val Pro Leu Ala Val Leu Gln Leu Arg Val Lys His Ala Asn 
465                 470                 475                 480 


Glu Thr Ser Leu Gly Ile Thr Trp Arg Ala Pro Leu Gly Glu Trp Glu 
                485                 490                 495     


Lys Tyr Ile Ile Ser Leu Met Asp Arg Glu Leu Leu Val Ile His Lys 
            500                 505                 510         


Ser Leu Ser Lys Asp Ala Lys Glu Phe Thr Phe Thr Asp Leu Met Pro 
        515                 520                 525             


Gly Arg Asn Tyr Lys Ala Thr Val Thr Ser Met Ser Gly Asp Leu Lys 
    530                 535                 540                 


Gln Ser Ser Ser Ile Lys Gly Arg Thr Val Pro Ala Gln Val Thr Asp 
545                 550                 555                 560 


Leu His Val Asn Asn Gln Gly Met Thr Ser Ser Leu Phe Thr Asn Trp 
                565                 570                 575     


Thr Lys Ala Leu Gly Asp Val Glu Phe Tyr Gln Val Leu Leu Ile His 
            580                 585                 590         


Glu Asn Val Val Val Lys Asn Glu Ser Val Ser Ser Asp Thr Ser Arg 
        595                 600                 605             


Tyr Ser Phe Arg Ala Leu Lys Pro Gly Ser Leu Tyr Ser Val Val Val 
    610                 615                 620                 


Thr Thr Val Ser Gly Gly Ile Ser Ser Arg Gln Val Val Ala Glu Gly 
625                 630                 635                 640 


Arg Thr Val Pro Ser Ser Val Ser Gly Val Thr Val Asn Asn Ser Gly 
                645                 650                 655     


Arg Asn Asp Tyr Leu Ser Val Ser Trp Leu Pro Ala Pro Gly Glu Val 
            660                 665                 670         


Asp His Tyr Val Val Ser Leu Ser His Glu Gly Lys Val Asp Gln Phe 
        675                 680                 685             


Leu Ile Ile Ala Lys Ser Val Ser Glu Cys Ser Phe Ser Ser Leu Thr 
    690                 695                 700                 


Pro Gly Arg Leu Tyr Asn Val Thr Val Thr Thr Lys Ser Gly Asn Tyr 
705                 710                 715                 720 


Ala Ser His Ser Phe Thr Glu Glu Arg Thr Val Pro Asp Lys Val Gln 
                725                 730                 735     


Gly Ile Ser Val Ser Asn Ser Ala Arg Ser Asp Tyr Leu Lys Val Ser 
            740                 745                 750         


Trp Val His Ala Thr Gly Asp Phe Asp His Tyr Glu Val Thr Ile Lys 
        755                 760                 765             


Asn Arg Glu Ser Phe Ile Gln Thr Lys Thr Ile Pro Lys Ser Glu Asn 
    770                 775                 780                 


Glu Cys Glu Phe Ile Glu Leu Val Pro Gly Arg Leu Tyr Ser Val Thr 
785                 790                 795                 800 


Val Ser Thr Lys Ser Gly Gln Tyr Glu Ala Ser Glu Gln Gly Thr Gly 
                805                 810                 815     


Arg Thr Ile Pro Glu Pro Val Lys Asp Leu Thr Leu Leu Asn Arg Ser 
            820                 825                 830         


Thr Glu Asp Leu His Val Thr Trp Ser Arg Ala Asn Gly Asp Val Asp 
        835                 840                 845             


Gln Tyr Glu Val Gln Leu Leu Phe Asn Asp Met Lys Val Phe Pro His 
    850                 855                 860                 


Ile His Leu Val Asn Thr Ala Thr Glu Tyr Lys Phe Thr Ala Leu Thr 
865                 870                 875                 880 


Pro Gly Arg His Tyr Lys Ile Leu Val Leu Thr Ile Ser Gly Asp Val 
                885                 890                 895     


Gln Gln Ser Ala Phe Ile Glu Gly Leu Pro Val Pro Ser Thr Val Lys 
            900                 905                 910         


Asn Ile His Ile Ser Ala Asn Gly Ala Thr Asp Arg Leu Met Val Thr 
        915                 920                 925             


Trp Ser Pro Gly Gly Gly Asp Val Asp Ser Tyr Val Val Ser Ala Phe 
    930                 935                 940                 


Arg Gln Asp Glu Lys Val Asp Ser Gln Thr Ile Pro Lys His Ala Ser 
945                 950                 955                 960 


Glu His Thr Phe His Arg Leu Glu Ala Gly Ala Lys Tyr Arg Ile Ala 
                965                 970                 975     


Ile Val Ser Val Ser Gly Ser Leu Arg Asn Gln Ile Asp Ala Leu Gly 
            980                 985                 990         


Gln Thr Val Pro Ala Ser Val Gln  Gly Val Val Ala Ala  Asn Ala Tyr 
        995                 1000                 1005             


Ser Ser  Asn Ser Leu Thr Val  Ser Trp Gln Lys Ala  Leu Gly Val 
    1010                 1015                 1020             


Ala Glu  Arg Tyr Asp Ile Leu  Leu Leu Asn Glu Asn  Gly Leu Leu 
    1025                 1030                 1035             


Leu Ser  Asn Val Ser Glu Pro  Ala Thr Ala Arg Gln  His Lys Phe 
    1040                 1045                 1050             


Glu Asp  Leu Thr Pro Gly Lys  Lys Tyr Lys Met Gln  Ile Leu Thr 
    1055                 1060                 1065             


Val Ser  Gly Gly Leu Phe Ser  Lys Glu Ser Gln Ala  Glu Gly Arg 
    1070                 1075                 1080             


Thr Val  Pro Ala Ala Val Thr  Asn Leu Arg Ile Thr  Glu Asn Ser 
    1085                 1090                 1095             


Ser Arg  Tyr Leu Ser Phe Gly  Trp Thr Ala Ser Glu  Gly Glu Leu 
    1100                 1105                 1110             


Ser Trp  Tyr Asn Ile Phe Leu  Tyr Asn Pro Asp Arg  Thr Leu Gln 
    1115                 1120                 1125             


Glu Arg  Ala Gln Val Asp Pro  Leu Val Gln Ser Phe  Ser Phe Gln 
    1130                 1135                 1140             


Asn Leu  Leu Gln Gly Arg Met  Tyr Lys Met Val Ile  Val Thr His 
    1145                 1150                 1155             


Ser Gly  Glu Leu Ser Asn Glu  Ser Phe Ile Phe Gly  Arg Thr Val 
    1160                 1165                 1170             


Pro Ala  Ala Val Asn His Leu  Lys Gly Ser His Arg  Asn Thr Thr 
    1175                 1180                 1185             


Asp Ser  Leu Trp Phe Ser Trp  Ser Pro Ala Ser Gly  Asp Phe Asp 
    1190                 1195                 1200             


Phe Tyr  Glu Leu Ile Leu Tyr  Asn Pro Asn Gly Thr  Lys Lys Glu 
    1205                 1210                 1215             


Asn Trp  Lys Glu Lys Asp Val  Thr Glu Trp Arg Phe  Gln Gly Leu 
    1220                 1225                 1230             


Val Pro  Gly Arg Lys Tyr Thr  Leu Tyr Val Val Thr  His Ser Gly 
    1235                 1240                 1245             


Asp Leu  Ser Asn Lys Val Thr  Gly Glu Gly Arg Thr  Ala Pro Ser 
    1250                 1255                 1260             


Pro Pro  Ser Leu Leu Ser Phe  Ala Asp Val Ala Asn  Thr Ser Leu 
    1265                 1270                 1275             


Ala Ile  Thr Trp Lys Gly Pro  Pro Asp Trp Thr Asp  Tyr Asn Asp 
    1280                 1285                 1290             


Phe Glu  Leu Gln Trp Phe Pro  Gly Asp Ala Leu Thr  Ile Phe Asn 
    1295                 1300                 1305             


Pro Tyr  Ser Ser Arg Lys Ser  Glu Gly Arg Ile Val  Tyr Gly Leu 
    1310                 1315                 1320             


His Pro  Gly Arg Ser Tyr Gln  Phe Ser Val Lys Thr  Val Ser Gly 
    1325                 1330                 1335             


Asp Ser  Trp Lys Thr Tyr Ser  Lys Pro Ile Ser Gly  Ser Val Arg 
    1340                 1345                 1350             


Thr Lys  Pro Asp Lys Ile Gln  Asn Leu His Cys Arg  Pro Gln Asn 
    1355                 1360                 1365             


Ser Thr  Ala Ile Ala Cys Ser  Trp Ile Pro Pro Asp  Ser Asp Phe 
    1370                 1375                 1380             


Asp Gly  Tyr Ser Ile Glu Cys  Arg Lys Met Asp Thr  Gln Glu Ile 
    1385                 1390                 1395             


Glu Phe  Ser Arg Lys Leu Glu  Lys Glu Lys Ser Leu  Leu Asn Ile 
    1400                 1405                 1410             


Met Met  Leu Val Pro His Lys  Arg Tyr Leu Val Ser  Ile Lys Val 
    1415                 1420                 1425             


Gln Ser  Ala Gly Met Thr Ser  Glu Val Val Glu Asp  Ser Thr Ile 
    1430                 1435                 1440             


Thr Met  Ile Asp Arg Pro Pro  Gln Pro Pro Pro His  Ile Arg Val 
    1445                 1450                 1455             


Asn Glu  Lys Asp Val Leu Ile  Ser Lys Ser Ser Ile  Asn Phe Thr 
    1460                 1465                 1470             


Val Asn  Cys Ser Trp Phe Ser  Asp Thr Asn Gly Ala  Val Lys Tyr 
    1475                 1480                 1485             


Phe Ala  Val Val Val Arg Glu  Ala Asp Ser Met Asp  Glu Leu Lys 
    1490                 1495                 1500             


Pro Glu  Gln Gln His Pro Leu  Pro Ser Tyr Leu Glu  Tyr Arg His 
    1505                 1510                 1515             


Asn Ala  Ser Ile Arg Val Tyr  Gln Thr Asn Tyr Phe  Ala Ser Lys 
    1520                 1525                 1530             


Cys Ala  Glu Ser Pro Asp Ser  Ser Ser Lys Ser Phe  Asn Ile Lys 
    1535                 1540                 1545             


Leu Gly  Ala Glu Met Asp Ser  Leu Gly Gly Lys Cys  Asp Pro Ser 
    1550                 1555                 1560             


Gln Gln  Lys Phe Cys Asp Gly  Pro Leu Lys Pro His  Thr Ala Tyr 
    1565                 1570                 1575             


Arg Ile  Ser Ile Arg Ala Phe  Thr Gln Leu Phe Asp  Glu Asp Leu 
    1580                 1585                 1590             


Lys Glu  Phe Thr Lys Pro Leu  Tyr Ser Asp Thr Phe  Phe Ser Met 
    1595                 1600                 1605             


Pro Ile  Thr Thr Glu Ser Glu  Pro Leu Phe Gly Val  Ile Glu Gly 
    1610                 1615                 1620             


Val Ser  Ala Gly Leu Phe Leu  Ile Gly Met Leu Val  Ala Leu Val 
    1625                 1630                 1635             


Ala Phe  Phe Ile Cys Arg Gln  Lys Ala Ser His Ser  Arg Glu Arg 
    1640                 1645                 1650             


Pro Ser  Ala Arg Leu Ser Ile  Arg Arg Asp Arg Pro  Leu Ser Val 
    1655                 1660                 1665             


His Leu  Asn Leu Gly Gln Lys  Gly Asn Arg Lys Thr  Ser Cys Pro 
    1670                 1675                 1680             


Ile Lys  Ile Asn Gln Phe Glu  Gly His Phe Met Lys  Leu Gln Ala 
    1685                 1690                 1695             


Asp Ser  Asn Tyr Leu Leu Ser  Lys Glu Tyr Glu Asp  Leu Lys Asp 
    1700                 1705                 1710             


Val Gly  Arg Ser Gln Ser Cys  Asp Ile Ala Leu Leu  Pro Glu Asn 
    1715                 1720                 1725             


Arg Gly  Lys Asn Arg Tyr Asn  Asn Ile Leu Pro Tyr  Asp Ala Ser 
    1730                 1735                 1740             


Arg Val  Lys Leu Ser Asn Val  Asp Asp Asp Pro Cys  Ser Asp Tyr 
    1745                 1750                 1755             


Ile Asn  Ala Ser Tyr Ile Pro  Gly Asn Asn Phe Arg  Arg Glu Tyr 
    1760                 1765                 1770             


Ile Ala  Thr Gln Gly Pro Leu  Pro Gly Thr Lys Asp  Asp Phe Trp 
    1775                 1780                 1785             


Lys Met  Ala Trp Glu Gln Asn  Val His Asn Ile Val  Met Val Thr 
    1790                 1795                 1800             


Gln Cys  Val Glu Lys Gly Arg  Val Lys Cys Asp His  Tyr Trp Pro 
    1805                 1810                 1815             


Ala Asp  Gln Asp Pro Leu Tyr  Tyr Gly Asp Leu Ile  Leu Gln Met 
    1820                 1825                 1830             


Val Ser  Glu Ser Val Leu Pro  Glu Trp Thr Ile Arg  Glu Phe Lys 
    1835                 1840                 1845             


Ile Cys  Ser Glu Glu Gln Leu  Asp Ala His Arg Leu  Ile Arg His 
    1850                 1855                 1860             


Phe His  Tyr Thr Val Trp Pro  Asp His Gly Val Pro  Glu Thr Thr 
    1865                 1870                 1875             


Gln Ser  Leu Ile Gln Phe Val  Arg Thr Val Arg Asp  Tyr Ile Asn 
    1880                 1885                 1890             


Arg Ser  Pro Gly Ala Gly Pro  Thr Val Val His Cys  Ser Ala Gly 
    1895                 1900                 1905             


Val Gly  Arg Thr Gly Thr Phe  Val Ala Leu Asp Arg  Ile Leu Gln 
    1910                 1915                 1920             


Gln Leu  Asp Ser Lys Asp Ser  Val Asp Ile Tyr Gly  Ala Val His 
    1925                 1930                 1935             


Asp Leu  Arg Leu His Arg Val  His Met Val Gln Thr  Glu Cys Gln 
    1940                 1945                 1950             


Tyr Val  Tyr Leu His Gln Cys  Val Arg Asp Val Leu  Arg Ala Lys 
    1955                 1960                 1965             


Lys Leu  Arg Asn Glu Gln Glu  Asn Pro Leu Phe Pro  Ile Tyr Glu 
    1970                 1975                 1980             


Asn Val  Asn Pro Glu Tyr His  Arg Asp Ala Ile Tyr  Ser Arg His 
    1985                 1990                 1995             


<210>  7
<211>  1619
<212>  PRT
<213>  Mus musculus

<400>  7

Met Leu Arg His Gly Ala Leu Thr Ala Leu Trp Ile Thr Leu Ser Val 
1               5                   10                  15      


Val Gln Thr Gly Val Ala Glu Gln Val Lys Cys Asn Phe Thr Leu Leu 
            20                  25                  30          


Glu Ser Arg Val Ser Ser Leu Ser Ala Ser Ile Gln Trp Arg Thr Phe 
        35                  40                  45              


Ala Ser Pro Cys Asn Phe Ser Leu Ile Tyr Ser Ser Asp Thr Ser Gly 
    50                  55                  60                  


Pro Met Trp Cys His Pro Ile Arg Ile Asp Asn Phe Thr Tyr Gly Cys 
65                  70                  75                  80  


Asn Pro Lys Asp Leu Gln Ala Gly Thr Val Tyr Asn Phe Arg Ile Val 
                85                  90                  95      


Ser Leu Asp Gly Glu Glu Ser Thr Leu Val Leu Gln Thr Asp Pro Leu 
            100                 105                 110         


Pro Pro Ala Arg Phe Glu Val Asn Arg Glu Lys Thr Ala Ser Thr Thr 
        115                 120                 125             


Leu Gln Val Arg Trp Thr Pro Ser Ser Gly Lys Val Ser Trp Tyr Glu 
    130                 135                 140                 


Val Gln Leu Phe Asp His Asn Asn Gln Lys Ile Gln Glu Val Gln Val 
145                 150                 155                 160 


Gln Glu Ser Thr Thr Trp Ser Gln Tyr Thr Phe Leu Asn Leu Thr Glu 
                165                 170                 175     


Gly Asn Ser Tyr Lys Val Ala Ile Thr Ala Val Ser Gly Glu Lys Arg 
            180                 185                 190         


Ser Phe Pro Val Tyr Ile Asn Gly Ser Thr Val Pro Ser Pro Val Lys 
        195                 200                 205             


Asp Leu Gly Ile Ser Pro Asn Pro Asn Ser Leu Leu Ile Ser Trp Ser 
    210                 215                 220                 


Arg Gly Ser Gly Asn Val Glu Gln Tyr Arg Leu Val Leu Met Asp Lys 
225                 230                 235                 240 


Gly Ala Ile Val Gln Asp Thr Asn Val Asp Arg Arg Asp Thr Ser Tyr 
                245                 250                 255     


Ala Phe His Glu Leu Thr Pro Gly His Leu Tyr Asn Leu Thr Ile Val 
            260                 265                 270         


Thr Met Ala Ser Gly Leu Gln Asn Ser Arg Trp Lys Leu Val Arg Thr 
        275                 280                 285             


Ala Pro Met Glu Val Ser Asn Leu Lys Val Thr Asn Asp Gly Arg Leu 
    290                 295                 300                 


Thr Ser Leu Asn Val Lys Trp Gln Lys Pro Pro Gly Asp Val Asp Ser 
305                 310                 315                 320 


Tyr Ser Ile Thr Leu Ser His Gln Gly Thr Ile Lys Glu Ser Lys Thr 
                325                 330                 335     


Leu Ala Pro Pro Val Thr Glu Thr Gln Phe Lys Asp Leu Val Pro Gly 
            340                 345                 350         


Arg Leu Tyr Gln Val Thr Ile Ser Cys Ile Ser Gly Glu Leu Ser Ala 
        355                 360                 365             


Glu Lys Ser Ala Ala Gly Arg Thr Val Pro Glu Lys Val Arg Asn Leu 
    370                 375                 380                 


Val Ser Tyr Asn Glu Ile Trp Met Lys Ser Phe Thr Val Asn Trp Thr 
385                 390                 395                 400 


Pro Pro Ala Gly Asp Trp Glu His Tyr Arg Ile Val Leu Phe Asn Glu 
                405                 410                 415     


Ser Leu Val Leu Leu Asn Thr Thr Val Gly Lys Glu Glu Thr His Tyr 
            420                 425                 430         


Ala Leu Asp Gly Leu Glu Leu Ile Pro Gly Arg Gln Tyr Glu Ile Glu 
        435                 440                 445             


Val Ile Val Glu Ser Gly Asn Leu Arg Asn Ser Glu Arg Cys Gln Gly 
    450                 455                 460                 


Arg Thr Val Pro Leu Ala Val Leu Gln Leu Arg Val Lys His Ala Asn 
465                 470                 475                 480 


Glu Thr Ser Leu Gly Ile Thr Trp Arg Ala Pro Leu Gly Glu Trp Glu 
                485                 490                 495     


Lys Tyr Ile Ile Ser Leu Met Asp Arg Glu Leu Leu Val Ile His Lys 
            500                 505                 510         


Ser Leu Ser Lys Asp Ala Lys Glu Phe Thr Phe Thr Asp Leu Met Pro 
        515                 520                 525             


Gly Arg Asn Tyr Lys Ala Thr Val Thr Ser Met Ser Gly Asp Leu Lys 
    530                 535                 540                 


Gln Ser Ser Ser Ile Lys Gly Arg Thr Val Pro Ala Gln Val Thr Asp 
545                 550                 555                 560 


Leu His Val Asn Asn Gln Gly Met Thr Ser Ser Leu Phe Thr Asn Trp 
                565                 570                 575     


Thr Lys Ala Leu Gly Asp Val Glu Phe Tyr Gln Val Leu Leu Ile His 
            580                 585                 590         


Glu Asn Val Val Val Lys Asn Glu Ser Val Ser Ser Asp Thr Ser Arg 
        595                 600                 605             


Tyr Ser Phe Arg Ala Leu Lys Pro Gly Ser Leu Tyr Ser Val Val Val 
    610                 615                 620                 


Thr Thr Val Ser Gly Gly Ile Ser Ser Arg Gln Val Val Ala Glu Gly 
625                 630                 635                 640 


Arg Thr Val Pro Ser Ser Val Ser Gly Val Thr Val Asn Asn Ser Gly 
                645                 650                 655     


Arg Asn Asp Tyr Leu Ser Val Ser Trp Leu Pro Ala Pro Gly Glu Val 
            660                 665                 670         


Asp His Tyr Val Val Ser Leu Ser His Glu Gly Lys Val Asp Gln Phe 
        675                 680                 685             


Leu Ile Ile Ala Lys Ser Val Ser Glu Cys Ser Phe Ser Ser Leu Thr 
    690                 695                 700                 


Pro Gly Arg Leu Tyr Asn Val Thr Val Thr Thr Lys Ser Gly Asn Tyr 
705                 710                 715                 720 


Ala Ser His Ser Phe Thr Glu Glu Arg Thr Val Pro Asp Lys Val Gln 
                725                 730                 735     


Gly Ile Ser Val Ser Asn Ser Ala Arg Ser Asp Tyr Leu Lys Val Ser 
            740                 745                 750         


Trp Val His Ala Thr Gly Asp Phe Asp His Tyr Glu Val Thr Ile Lys 
        755                 760                 765             


Asn Arg Glu Ser Phe Ile Gln Thr Lys Thr Ile Pro Lys Ser Glu Asn 
    770                 775                 780                 


Glu Cys Glu Phe Ile Glu Leu Val Pro Gly Arg Leu Tyr Ser Val Thr 
785                 790                 795                 800 


Val Ser Thr Lys Ser Gly Gln Tyr Glu Ala Ser Glu Gln Gly Thr Gly 
                805                 810                 815     


Arg Thr Ile Pro Glu Pro Val Lys Asp Leu Thr Leu Leu Asn Arg Ser 
            820                 825                 830         


Thr Glu Asp Leu His Val Thr Trp Ser Arg Ala Asn Gly Asp Val Asp 
        835                 840                 845             


Gln Tyr Glu Val Gln Leu Leu Phe Asn Asp Met Lys Val Phe Pro His 
    850                 855                 860                 


Ile His Leu Val Asn Thr Ala Thr Glu Tyr Lys Phe Thr Ala Leu Thr 
865                 870                 875                 880 


Pro Gly Arg His Tyr Lys Ile Leu Val Leu Thr Ile Ser Gly Asp Val 
                885                 890                 895     


Gln Gln Ser Ala Phe Ile Glu Gly Leu Pro Val Pro Ser Thr Val Lys 
            900                 905                 910         


Asn Ile His Ile Ser Ala Asn Gly Ala Thr Asp Arg Leu Met Val Thr 
        915                 920                 925             


Trp Ser Pro Gly Gly Gly Asp Val Asp Ser Tyr Val Val Ser Ala Phe 
    930                 935                 940                 


Arg Gln Asp Glu Lys Val Asp Ser Gln Thr Ile Pro Lys His Ala Ser 
945                 950                 955                 960 


Glu His Thr Phe His Arg Leu Glu Ala Gly Ala Lys Tyr Arg Ile Ala 
                965                 970                 975     


Ile Val Ser Val Ser Gly Ser Leu Arg Asn Gln Ile Asp Ala Leu Gly 
            980                 985                 990         


Gln Thr Val Pro Ala Ser Val Gln  Gly Val Val Ala Ala  Asn Ala Tyr 
        995                 1000                 1005             


Ser Ser  Asn Ser Leu Thr Val  Ser Trp Gln Lys Ala  Leu Gly Val 
    1010                 1015                 1020             


Ala Glu  Arg Tyr Asp Ile Leu  Leu Leu Asn Glu Asn  Gly Leu Leu 
    1025                 1030                 1035             


Leu Ser  Asn Val Ser Glu Pro  Ala Thr Ala Arg Gln  His Lys Phe 
    1040                 1045                 1050             


Glu Asp  Leu Thr Pro Gly Lys  Lys Tyr Lys Met Gln  Ile Leu Thr 
    1055                 1060                 1065             


Val Ser  Gly Gly Leu Phe Ser  Lys Glu Ser Gln Ala  Glu Gly Arg 
    1070                 1075                 1080             


Thr Val  Pro Ala Ala Val Thr  Asn Leu Arg Ile Thr  Glu Asn Ser 
    1085                 1090                 1095             


Ser Arg  Tyr Leu Ser Phe Gly  Trp Thr Ala Ser Glu  Gly Glu Leu 
    1100                 1105                 1110             


Ser Trp  Tyr Asn Ile Phe Leu  Tyr Asn Pro Asp Arg  Thr Leu Gln 
    1115                 1120                 1125             


Glu Arg  Ala Gln Val Asp Pro  Leu Val Gln Ser Phe  Ser Phe Gln 
    1130                 1135                 1140             


Asn Leu  Leu Gln Gly Arg Met  Tyr Lys Met Val Ile  Val Thr His 
    1145                 1150                 1155             


Ser Gly  Glu Leu Ser Asn Glu  Ser Phe Ile Phe Gly  Arg Thr Val 
    1160                 1165                 1170             


Pro Ala  Ala Val Asn His Leu  Lys Gly Ser His Arg  Asn Thr Thr 
    1175                 1180                 1185             


Asp Ser  Leu Trp Phe Ser Trp  Ser Pro Ala Ser Gly  Asp Phe Asp 
    1190                 1195                 1200             


Phe Tyr  Glu Leu Ile Leu Tyr  Asn Pro Asn Gly Thr  Lys Lys Glu 
    1205                 1210                 1215             


Asn Trp  Lys Glu Lys Asp Val  Thr Glu Trp Arg Phe  Gln Gly Leu 
    1220                 1225                 1230             


Val Pro  Gly Arg Lys Tyr Thr  Leu Tyr Val Val Thr  His Ser Gly 
    1235                 1240                 1245             


Asp Leu  Ser Asn Lys Val Thr  Gly Glu Gly Arg Thr  Ala Pro Ser 
    1250                 1255                 1260             


Pro Pro  Ser Leu Leu Ser Phe  Ala Asp Val Ala Asn  Thr Ser Leu 
    1265                 1270                 1275             


Ala Ile  Thr Trp Lys Gly Pro  Pro Asp Trp Thr Asp  Tyr Asn Asp 
    1280                 1285                 1290             


Phe Glu  Leu Gln Trp Phe Pro  Gly Asp Ala Leu Thr  Ile Phe Asn 
    1295                 1300                 1305             


Pro Tyr  Ser Ser Arg Lys Ser  Glu Gly Arg Ile Val  Tyr Gly Leu 
    1310                 1315                 1320             


His Pro  Gly Arg Ser Tyr Gln  Phe Ser Val Lys Thr  Val Ser Gly 
    1325                 1330                 1335             


Asp Ser  Trp Lys Thr Tyr Ser  Lys Pro Ile Ser Gly  Ser Val Arg 
    1340                 1345                 1350             


Thr Lys  Pro Asp Lys Ile Gln  Asn Leu His Cys Arg  Pro Gln Asn 
    1355                 1360                 1365             


Ser Thr  Ala Ile Ala Cys Ser  Trp Ile Pro Pro Asp  Ser Asp Phe 
    1370                 1375                 1380             


Asp Gly  Tyr Ser Ile Glu Cys  Arg Lys Met Asp Thr  Gln Glu Ile 
    1385                 1390                 1395             


Glu Phe  Ser Arg Lys Leu Glu  Lys Glu Lys Ser Leu  Leu Asn Ile 
    1400                 1405                 1410             


Met Met  Leu Val Pro His Lys  Arg Tyr Leu Val Ser  Ile Lys Val 
    1415                 1420                 1425             


Gln Ser  Ala Gly Met Thr Ser  Glu Val Val Glu Asp  Ser Thr Ile 
    1430                 1435                 1440             


Thr Met  Ile Asp Arg Pro Pro  Gln Pro Pro Pro His  Ile Arg Val 
    1445                 1450                 1455             


Asn Glu  Lys Asp Val Leu Ile  Ser Lys Ser Ser Ile  Asn Phe Thr 
    1460                 1465                 1470             


Val Asn  Cys Ser Trp Phe Ser  Asp Thr Asn Gly Ala  Val Lys Tyr 
    1475                 1480                 1485             


Phe Ala  Val Val Val Arg Glu  Ala Asp Ser Met Asp  Glu Leu Lys 
    1490                 1495                 1500             


Pro Glu  Gln Gln His Pro Leu  Pro Ser Tyr Leu Glu  Tyr Arg His 
    1505                 1510                 1515             


Asn Ala  Ser Ile Arg Val Tyr  Gln Thr Asn Tyr Phe  Ala Ser Lys 
    1520                 1525                 1530             


Cys Ala  Glu Ser Pro Asp Ser  Ser Ser Lys Ser Phe  Asn Ile Lys 
    1535                 1540                 1545             


Leu Gly  Ala Glu Met Asp Ser  Leu Gly Gly Lys Cys  Asp Pro Ser 
    1550                 1555                 1560             


Gln Gln  Lys Phe Cys Asp Gly  Pro Leu Lys Pro His  Thr Ala Tyr 
    1565                 1570                 1575             


Arg Ile  Ser Ile Arg Ala Phe  Thr Gln Leu Phe Asp  Glu Asp Leu 
    1580                 1585                 1590             


Lys Glu  Phe Thr Lys Pro Leu  Tyr Ser Asp Thr Phe  Phe Ser Met 
    1595                 1600                 1605             


Pro Ile  Thr Thr Glu Ser Glu  Pro Leu Phe Gly 
    1610                 1615                 


