                         SEQUENCE LISTING




<110>  Vaccinex, Inc.
       SMITH, Ernest S.
       
       ZAUDERER, Maurice
 


<120>  USE OF SEMAPHORIN-4D BINDING MOLECULES FOR
       MODULATION OF BLOOD BRAIN BARRIER PERMEABILITY



<130>  1843.068PC03/EJH/BNC

<140>  To be assigned
<141>  Herewith

<150>  US 61/593,641
<151>  2012-02-01

<150>  US 61/555,726
<151>  2011-11-04

<150>  US 61/545,809
<151>  2011-10-11

<160>  40    



<170>  PatentIn version 3.3



<210>  1
<211>  862
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Met Cys Thr Pro Ile Arg Gly Leu Leu Met Ala Leu Ala Val 
1               5                   10                  15      


Met Phe Gly Thr Ala Met Ala Phe Ala Pro Ile Pro Arg Ile Thr Trp 
            20                  25                  30          


Glu His Arg Glu Val His Leu Val Gln Phe His Glu Pro Asp Ile Tyr 
        35                  40                  45              


Asn Tyr Ser Ala Leu Leu Leu Ser Glu Asp Lys Asp Thr Leu Tyr Ile 
    50                  55                  60                  


Gly Ala Arg Glu Ala Val Phe Ala Val Asn Ala Leu Asn Ile Ser Glu 
65                  70                  75                  80  


Lys Gln His Glu Val Tyr Trp Lys Val Ser Glu Asp Lys Lys Ala Lys 
                85                  90                  95      


Cys Ala Glu Lys Gly Lys Ser Lys Gln Thr Glu Cys Leu Asn Tyr Ile 
            100                 105                 110         


Arg Val Leu Gln Pro Leu Ser Ala Thr Ser Leu Tyr Val Cys Gly Thr 
        115                 120                 125             


Asn Ala Phe Gln Pro Ala Cys Asp His Leu Asn Leu Thr Ser Phe Lys 
    130                 135                 140                 


Phe Leu Gly Lys Asn Glu Asp Gly Lys Gly Arg Cys Pro Phe Asp Pro 
145                 150                 155                 160 


Ala His Ser Tyr Thr Ser Val Met Val Asp Gly Glu Leu Tyr Ser Gly 
                165                 170                 175     


Thr Ser Tyr Asn Phe Leu Gly Ser Glu Pro Ile Ile Ser Arg Asn Ser 
            180                 185                 190         


Ser His Ser Pro Leu Arg Thr Glu Tyr Ala Ile Pro Trp Leu Asn Glu 
        195                 200                 205             


Pro Ser Phe Val Phe Ala Asp Val Ile Arg Lys Ser Pro Asp Ser Pro 
    210                 215                 220                 


Asp Gly Glu Asp Asp Arg Val Tyr Phe Phe Phe Thr Glu Val Ser Val 
225                 230                 235                 240 


Glu Tyr Glu Phe Val Phe Arg Val Leu Ile Pro Arg Ile Ala Arg Val 
                245                 250                 255     


Cys Lys Gly Asp Gln Gly Gly Leu Arg Thr Leu Gln Lys Lys Trp Thr 
            260                 265                 270         


Ser Phe Leu Lys Ala Arg Leu Ile Cys Ser Arg Pro Asp Ser Gly Leu 
        275                 280                 285             


Val Phe Asn Val Leu Arg Asp Val Phe Val Leu Arg Ser Pro Gly Leu 
    290                 295                 300                 


Lys Val Pro Val Phe Tyr Ala Leu Phe Thr Pro Gln Leu Asn Asn Val 
305                 310                 315                 320 


Gly Leu Ser Ala Val Cys Ala Tyr Asn Leu Ser Thr Ala Glu Glu Val 
                325                 330                 335     


Phe Ser His Gly Lys Tyr Met Gln Ser Thr Thr Val Glu Gln Ser His 
            340                 345                 350         


Thr Lys Trp Val Arg Tyr Asn Gly Pro Val Pro Lys Pro Arg Pro Gly 
        355                 360                 365             


Ala Cys Ile Asp Ser Glu Ala Arg Ala Ala Asn Tyr Thr Ser Ser Leu 
    370                 375                 380                 


Asn Leu Pro Asp Lys Thr Leu Gln Phe Val Lys Asp His Pro Leu Met 
385                 390                 395                 400 


Asp Asp Ser Val Thr Pro Ile Asp Asn Arg Pro Arg Leu Ile Lys Lys 
                405                 410                 415     


Asp Val Asn Tyr Thr Gln Ile Val Val Asp Arg Thr Gln Ala Leu Asp 
            420                 425                 430         


Gly Thr Val Tyr Asp Val Met Phe Val Ser Thr Asp Arg Gly Ala Leu 
        435                 440                 445             


His Lys Ala Ile Ser Leu Glu His Ala Val His Ile Ile Glu Glu Thr 
    450                 455                 460                 


Gln Leu Phe Gln Asp Phe Glu Pro Val Gln Thr Leu Leu Leu Ser Ser 
465                 470                 475                 480 


Lys Lys Gly Asn Arg Phe Val Tyr Ala Gly Ser Asn Ser Gly Val Val 
                485                 490                 495     


Gln Ala Pro Leu Ala Phe Cys Gly Lys His Gly Thr Cys Glu Asp Cys 
            500                 505                 510         


Val Leu Ala Arg Asp Pro Tyr Cys Ala Trp Ser Pro Pro Thr Ala Thr 
        515                 520                 525             


Cys Val Ala Leu His Gln Thr Glu Ser Pro Ser Arg Gly Leu Ile Gln 
    530                 535                 540                 


Glu Met Ser Gly Asp Ala Ser Val Cys Pro Asp Lys Ser Lys Gly Ser 
545                 550                 555                 560 


Tyr Arg Gln His Phe Phe Lys His Gly Gly Thr Ala Glu Leu Lys Cys 
                565                 570                 575     


Ser Gln Lys Ser Asn Leu Ala Arg Val Phe Trp Lys Phe Gln Asn Gly 
            580                 585                 590         


Val Leu Lys Ala Glu Ser Pro Lys Tyr Gly Leu Met Gly Arg Lys Asn 
        595                 600                 605             


Leu Leu Ile Phe Asn Leu Ser Glu Gly Asp Ser Gly Val Tyr Gln Cys 
    610                 615                 620                 


Leu Ser Glu Glu Arg Val Lys Asn Lys Thr Val Phe Gln Val Val Ala 
625                 630                 635                 640 


Lys His Val Leu Glu Val Lys Val Val Pro Lys Pro Val Val Ala Pro 
                645                 650                 655     


Thr Leu Ser Val Val Gln Thr Glu Gly Ser Arg Ile Ala Thr Lys Val 
            660                 665                 670         


Leu Val Ala Ser Thr Gln Gly Ser Ser Pro Pro Thr Pro Ala Val Gln 
        675                 680                 685             


Ala Thr Ser Ser Gly Ala Ile Thr Leu Pro Pro Lys Pro Ala Pro Thr 
    690                 695                 700                 


Gly Thr Ser Cys Glu Pro Lys Ile Val Ile Asn Thr Val Pro Gln Leu 
705                 710                 715                 720 


His Ser Glu Lys Thr Met Tyr Leu Lys Ser Ser Asp Asn Arg Leu Leu 
                725                 730                 735     


Met Ser Leu Phe Leu Phe Phe Phe Val Leu Phe Leu Cys Leu Phe Phe 
            740                 745                 750         


Tyr Asn Cys Tyr Lys Gly Tyr Leu Pro Arg Gln Cys Leu Lys Phe Arg 
        755                 760                 765             


Ser Ala Leu Leu Ile Gly Lys Lys Lys Pro Lys Ser Asp Phe Cys Asp 
    770                 775                 780                 


Arg Glu Gln Ser Leu Lys Glu Thr Leu Val Glu Pro Gly Ser Phe Ser 
785                 790                 795                 800 


Gln Gln Asn Gly Glu His Pro Lys Pro Ala Leu Asp Thr Gly Tyr Glu 
                805                 810                 815     


Thr Glu Gln Asp Thr Ile Thr Ser Lys Val Pro Thr Asp Arg Glu Asp 
            820                 825                 830         


Ser Gln Arg Ile Asp Asp Leu Ser Ala Arg Asp Lys Pro Phe Asp Val 
        835                 840                 845             


Lys Cys Glu Leu Lys Phe Ala Asp Ser Asp Ala Asp Gly Asp 
    850                 855                 860         


<210>  2
<211>  861
<212>  PRT
<213>  Murine sp.

<400>  2

Met Arg Met Cys Ala Pro Val Arg Gly Leu Phe Leu Ala Leu Val Val 
1               5                   10                  15      


Val Leu Arg Thr Ala Val Ala Phe Ala Pro Val Pro Arg Leu Thr Trp 
            20                  25                  30          


Glu His Gly Glu Val Gly Leu Val Gln Phe His Lys Pro Gly Ile Phe 
        35                  40                  45              


Asn Tyr Ser Ala Leu Leu Met Ser Glu Asp Lys Asp Thr Leu Tyr Val 
    50                  55                  60                  


Gly Ala Arg Glu Ala Val Phe Ala Val Asn Ala Leu Asn Ile Ser Glu 
65                  70                  75                  80  


Lys Gln His Glu Val Tyr Trp Lys Val Ser Glu Asp Lys Lys Ser Lys 
                85                  90                  95      


Cys Ala Glu Lys Gly Lys Ser Lys Gln Thr Glu Cys Leu Asn Tyr Ile 
            100                 105                 110         


Arg Val Leu Gln Pro Leu Ser Ser Thr Ser Leu Tyr Val Cys Gly Thr 
        115                 120                 125             


Asn Ala Phe Gln Pro Thr Cys Asp His Leu Asn Leu Thr Ser Phe Lys 
    130                 135                 140                 


Phe Leu Gly Lys Ser Glu Asp Gly Lys Gly Arg Cys Pro Phe Asp Pro 
145                 150                 155                 160 


Ala His Ser Tyr Thr Ser Val Met Val Gly Gly Glu Leu Tyr Ser Gly 
                165                 170                 175     


Thr Ser Tyr Asn Phe Leu Gly Ser Glu Pro Ile Ile Ser Arg Asn Ser 
            180                 185                 190         


Ser His Ser Pro Leu Arg Thr Glu Tyr Ala Ile Pro Trp Leu Asn Glu 
        195                 200                 205             


Pro Ser Phe Val Phe Ala Asp Val Ile Gln Lys Ser Pro Asp Gly Pro 
    210                 215                 220                 


Glu Gly Glu Asp Asp Lys Val Tyr Phe Phe Phe Thr Glu Val Ser Val 
225                 230                 235                 240 


Glu Tyr Glu Phe Val Phe Lys Leu Met Ile Pro Arg Val Ala Arg Val 
                245                 250                 255     


Cys Lys Gly Asp Gln Gly Gly Leu Arg Thr Leu Gln Lys Lys Trp Thr 
            260                 265                 270         


Ser Phe Leu Lys Ala Arg Leu Ile Cys Ser Lys Pro Asp Ser Gly Leu 
        275                 280                 285             


Val Phe Asn Ile Leu Gln Asp Val Phe Val Leu Arg Ala Pro Gly Leu 
    290                 295                 300                 


Lys Glu Pro Val Phe Tyr Ala Val Phe Thr Pro Gln Leu Asn Asn Val 
305                 310                 315                 320 


Gly Leu Ser Ala Val Cys Ala Tyr Thr Leu Ala Thr Val Glu Ala Val 
                325                 330                 335     


Phe Ser Arg Gly Lys Tyr Met Gln Ser Ala Thr Val Glu Gln Ser His 
            340                 345                 350         


Thr Lys Trp Val Arg Tyr Asn Gly Pro Val Pro Thr Pro Arg Pro Gly 
        355                 360                 365             


Ala Cys Ile Asp Ser Glu Ala Arg Ala Ala Asn Tyr Thr Ser Ser Leu 
    370                 375                 380                 


Asn Leu Pro Asp Lys Thr Leu Gln Phe Val Lys Asp His Pro Leu Met 
385                 390                 395                 400 


Asp Asp Ser Val Thr Pro Ile Asp Asn Arg Pro Lys Leu Ile Lys Lys 
                405                 410                 415     


Asp Val Asn Tyr Thr Gln Ile Val Val Asp Arg Thr Gln Ala Leu Asp 
            420                 425                 430         


Gly Thr Phe Tyr Asp Val Met Phe Ile Ser Thr Asp Arg Gly Ala Leu 
        435                 440                 445             


His Lys Ala Val Ile Leu Thr Lys Glu Val His Val Ile Glu Glu Thr 
    450                 455                 460                 


Gln Leu Phe Arg Asp Ser Glu Pro Val Leu Thr Leu Leu Leu Ser Ser 
465                 470                 475                 480 


Lys Lys Gly Arg Lys Phe Val Tyr Ala Gly Ser Asn Ser Gly Val Val 
                485                 490                 495     


Gln Ala Pro Leu Ala Phe Cys Glu Lys His Gly Ser Cys Glu Asp Cys 
            500                 505                 510         


Val Leu Ala Arg Asp Pro Tyr Cys Ala Trp Ser Pro Ala Ile Lys Ala 
        515                 520                 525             


Cys Val Thr Leu His Gln Glu Glu Ala Ser Ser Arg Gly Trp Ile Gln 
    530                 535                 540                 


Asp Met Ser Gly Asp Thr Ser Ser Cys Leu Asp Lys Ser Lys Glu Ser 
545                 550                 555                 560 


Phe Asn Gln His Phe Phe Lys His Gly Gly Thr Ala Glu Leu Lys Cys 
                565                 570                 575     


Phe Gln Lys Ser Asn Leu Ala Arg Val Val Trp Lys Phe Gln Asn Gly 
            580                 585                 590         


Glu Leu Lys Ala Ala Ser Pro Lys Tyr Gly Phe Val Gly Arg Lys His 
        595                 600                 605             


Leu Leu Ile Phe Asn Leu Ser Asp Gly Asp Ser Gly Val Tyr Gln Cys 
    610                 615                 620                 


Leu Ser Glu Glu Arg Val Arg Asn Lys Thr Val Ser Gln Leu Leu Ala 
625                 630                 635                 640 


Lys His Val Leu Glu Val Lys Met Val Pro Arg Thr Pro Pro Ser Pro 
                645                 650                 655     


Thr Ser Glu Asp Ala Gln Thr Glu Gly Ser Lys Ile Thr Ser Lys Met 
            660                 665                 670         


Pro Val Ala Ser Thr Gln Gly Ser Ser Pro Pro Thr Pro Ala Leu Trp 
        675                 680                 685             


Ala Thr Ser Pro Arg Ala Ala Thr Leu Pro Pro Lys Ser Ser Ser Gly 
    690                 695                 700                 


Thr Ser Cys Glu Pro Lys Met Val Ile Asn Thr Val Pro Gln Leu His 
705                 710                 715                 720 


Ser Glu Lys Thr Val Tyr Leu Lys Ser Ser Asp Asn Arg Leu Leu Met 
                725                 730                 735     


Ser Leu Leu Leu Phe Ile Phe Val Leu Phe Leu Cys Leu Phe Ser Tyr 
            740                 745                 750         


Asn Cys Tyr Lys Gly Tyr Leu Pro Gly Gln Cys Leu Lys Phe Arg Ser 
        755                 760                 765             


Ala Leu Leu Leu Gly Lys Lys Thr Pro Lys Ser Asp Phe Ser Asp Leu 
    770                 775                 780                 


Glu Gln Ser Val Lys Glu Thr Leu Val Glu Pro Gly Ser Phe Ser Gln 
785                 790                 795                 800 


Gln Asn Gly Asp His Pro Lys Pro Ala Leu Asp Thr Gly Tyr Glu Thr 
                805                 810                 815     


Glu Gln Asp Thr Ile Thr Ser Lys Val Pro Thr Asp Arg Glu Asp Ser 
            820                 825                 830         


Gln Arg Ile Asp Glu Leu Ser Ala Arg Asp Lys Pro Phe Asp Val Lys 
        835                 840                 845             


Cys Glu Leu Lys Phe Ala Asp Ser Asp Ala Asp Gly Asp 
    850                 855                 860     


<210>  3
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Polynucleotide anti-CD100 VH CDR1

<400>  3
ggctacagct tcagcgacta ctacatgcac                                      30


<210>  4
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  Polynucleotide anti-CD100 VH CDR2

<400>  4
cagattaatc ctaccactgg cggcgctagc tacaaccaga agttcaaggg c              51


<210>  5
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Polynucleotide anti-CD100 VH CDR3

<400>  5
tattactacg gcagacactt cgatgtc                                         27


<210>  6
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide anti-CD100 VH CDR1

<400>  6

Gly Tyr Ser Phe Ser Asp Tyr Tyr Met His 
1               5                   10  


<210>  7
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide anti-CD100 VH CDR2

<400>  7

Gln Ile Asn Pro Thr Thr Gly Gly Ala Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    

<210>  8
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide anti-CD100 VH CDR3

<400>  8

Tyr Tyr Tyr Gly Arg His Phe Asp Val 
1               5                   


<210>  9
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide anti-CD100 VH 2503

<400>  9

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Asn Pro Thr Thr Gly Gly Ala Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Tyr Gly Arg His Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  10
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide anti-CD100 VH 67

<400>  10

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ser Pro Glu Asn Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Asn Pro Thr Thr Gly Gly Ala Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Lys Ser Leu Thr Ser Glu Glu Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Tyr Tyr Tyr Gly Arg His Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  11
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Polynucleotide anti-CD100 VL CDR1

<400>  11
aaggccagcc aaagcgtgga ttatgatggc gatagctata tgaac                     45


<210>  12
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Polynucleotide anti-CD100 VL CDR2

<400>  12
gctgcatcca atctggaaag c                                               21


<210>  13
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Polynucleotide anti-CD100 VL CDR3

<400>  13
cagcaaagca atgaggatcc ctacacc                                         27


<210>  14
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide anti-CD100 VL CDR1

<400>  14

Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Met Asn 
1               5                   10                  15  


<210>  15
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide anti-CD100 VL CDR2

<400>  15

Ala Ala Ser Asn Leu Glu Ser 
1               5           


<210>  16
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide anti-CD100 VL CDR3

<400>  16

Gln Gln Ser Asn Glu Asp Pro Tyr Thr 
1               5                   


<210>  17
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide anti-CD100 VL 2503

<400>  17

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  18
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide anti-CD100 VL 67

<400>  18

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  19
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  Polynucleotide anti-CD100 VH 2503

<400>  19
caggtgcagc tggtgcagag cggcgctgag gtgaagaagc ctggcagcag cgtgaaggtc     60

tcctgcaagg ctagcggcta cagcttcagc gactactaca tgcactgggt gagacaggcc    120

cctggccaag gcctggagtg gatgggccag attaatccta ccactggcgg cgctagctac    180

aaccagaagt tcaagggcaa ggccaccatt accgtggaca aaagcaccag cacagcctac    240

atggagctga gcagcctgag aagcgaggac accgccgtgt attactgtgc cagatattac    300

tacggcagac acttcgatgt ctggggccaa ggcaccacgg tcaccgtctc ttca          354


<210>  20
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  Polynucleotide anti-CD100 VH 67

<400>  20
caggtccagc tgcagcagtc tggacctgag ctggtgaagc ctggggcttc agtgaagata     60

tcctgcaagg cttctggtta ctcattcagt gactactaca tgcactgggt gaagcaaagt    120

cctgaaaata gtcttgagtg gattggacag attaatccta ccactggggg tgctagctac    180

aaccagaagt tcaagggcaa ggccacatta actgtagata aatcctccag cacagcctac    240

atgcagctca agagcctgac atctgaagag tctgcagtct attactgtac aagatattac    300

tacggtagac acttcgatgt ctggggccaa gggaccacgg tcaccgtttc ctca          354


<210>  21
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Polynucleotide anti-CD100 VL 2503

<400>  21
gacatcgtga tgacccagag cccagacagc ctggctgtga gcctgggcga gagggccacc     60

atcaactgca aggccagcca aagcgtggat tatgatggcg atagctatat gaactggtac    120

cagcagaaac caggccagcc tcctaagctg ctgatttacg ctgcatccaa tctggaaagc    180

ggcgtgcctg acagattcag cggcagcggc agcggcacag atttcactct gaccatcagc    240

agcctgcagg ctgaagatgt ggcagtgtat tactgtcagc aaagcaatga ggatccctac    300

accttcggcc aagggaccaa gctcgagatc aaa                                 333


<210>  22
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Polynucleotide anti-CD100 VL 67

<400>  22
gacattgtga tgacccagtc tccagcttct ttggctgtgt ctctagggca gagggccacc     60

atctcctgca aggccagcca aagtgttgat tatgatggtg atagttatat gaactggtac    120

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa tctagaatct    180

gggatcccag ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat    240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc aaagtaatga ggatccgtac    300

acgttcggag gggggaccaa gctcgagatc aaa                                 333


<210>  23
<211>  2586
<212>  DNA
<213>  Homo sapiens

<400>  23
atgaggatgt gcacccccat tagggggctg ctcatggccc ttgcagtgat gtttgggaca     60

gcgatggcat ttgcacccat accccggatc acctgggagc acagagaggt gcacctggtg    120

cagtttcatg agccagacat ctacaactac tcagccttgc tgctgagcga ggacaaggac    180

accttgtaca taggtgcccg ggaggcggtc ttcgctgtga acgcactcaa catctccgag    240

aagcagcatg aggtgtattg gaaggtctca gaagacaaaa aagcaaaatg tgcagaaaag    300

gggaaatcaa aacagacaga gtgcctcaac tacatccggg tgctgcagcc actcagcgcc    360

acttcccttt acgtgtgtgg gaccaacgca ttccagccgg cctgtgacca cctgaactta    420

acatccttta agtttctggg gaaaaatgaa gatggcaaag gaagatgtcc ctttgaccca    480

gcacacagct acacatccgt catggttgat ggagaacttt attcggggac gtcgtataat    540

tttttgggaa gtgaacccat catctcccga aattcttccc acagtcctct gaggacagaa    600

tatgcaatcc cttggctgaa cgagcctagt ttcgtgtttg ctgacgtgat ccgaaaaagc    660

ccagacagcc ccgacggcga ggatgacagg gtctacttct tcttcacgga ggtgtctgtg    720

gagtatgagt ttgtgttcag ggtgctgatc ccacggatag caagagtgtg caagggggac    780

cagggcggcc tgaggacctt gcagaagaaa tggacctcct tcctgaaagc ccgactcatc    840

tgctcccggc cagacagcgg cttggtcttc aatgtgctgc gggatgtctt cgtgctcagg    900

tccccgggcc tgaaggtgcc tgtgttctat gcactcttca ccccacagct gaacaacgtg    960

gggctgtcgg cagtgtgcgc ctacaacctg tccacagccg aggaggtctt ctcccacggg   1020

aagtacatgc agagcaccac agtggagcag tcccacacca agtgggtgcg ctataatggc   1080

ccggtaccca agccgcggcc tggagcgtgc atcgacagcg aggcacgggc cgccaactac   1140

accagctcct tgaatttgcc agacaagacg ctgcagttcg ttaaagacca ccctttgatg   1200

gatgactcgg taaccccaat agacaacagg cccaggttaa tcaagaaaga tgtgaactac   1260

acccagatcg tggtggaccg gacccaggcc ctggatggga ctgtctatga tgtcatgttt   1320

gtcagcacag accggggagc tctgcacaaa gccatcagcc tcgagcacgc tgttcacatc   1380

atcgaggaga cccagctctt ccaggacttt gagccagtcc agaccctgct gctgtcttca   1440

aagaagggca acaggtttgt ctatgctggc tctaactcgg gcgtggtcca ggccccgctg   1500

gccttctgtg ggaagcacgg cacctgcgag gactgtgtgc tggcgcggga cccctactgc   1560

gcctggagcc cgcccacagc gacctgcgtg gctctgcacc agaccgagag ccccagcagg   1620

ggtttgattc aggagatgag cggcgatgct tctgtgtgcc cggataaaag taaaggaagt   1680

taccggcagc attttttcaa gcacggtggc acagcggaac tgaaatgctc ccaaaaatcc   1740

aacctggccc gggtcttttg gaagttccag aatggcgtgt tgaaggccga gagccccaag   1800

tacggtctta tgggcagaaa aaacttgctc atcttcaact tgtcagaagg agacagtggg   1860

gtgtaccagt gcctgtcaga ggagagggtt aagaacaaaa cggtcttcca agtggtcgcc   1920

aagcacgtcc tggaagtgaa ggtggttcca aagcccgtag tggcccccac cttgtcagtt   1980

gttcagacag aaggtagtag gattgccacc aaagtgttgg tggcatccac ccaagggtct   2040

tctcccccaa ccccagccgt gcaggccacc tcctccgggg ccatcaccct tcctcccaag   2100

cctgcgccca ccggcacatc ctgcgaacca aagatcgtca tcaacacggt cccccagctc   2160

cactcggaga aaaccatgta tcttaagtcc agcgacaacc gcctcctcat gtccctcttc   2220

ctcttcttct ttgttctctt cctctgcctc tttttctaca actgctataa gggatacctg   2280

cccagacagt gcttgaaatt ccgctcggcc ctactaattg ggaagaagaa gcccaagtca   2340

gatttctgtg accgtgagca gagcctgaag gagacgttag tagagccagg gagcttctcc   2400

cagcagaatg gggagcaccc caagccagcc ctggacaccg gctatgagac cgagcaagac   2460

accatcacca gcaaagtccc cacggatagg gaggactcac agaggatcga cgacctttct   2520

gccagggaca agccctttga cgtcaagtgt gagctgaagt tcgctgactc agacgcagat   2580

ggagac                                                              2586


<210>  24
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide epitope of proteolipid protein PLP(139-151)

<400>  24

His Ser Leu Gly Lys Trp Leu Gly His Pro Asp Lys Phe 
1               5                   10              


<210>  25
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide anti-CD100 VH 76

<400>  25

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Thr Gly Tyr Ser Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Tyr Gly Trp Thr Met Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  26
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide anti-CD100 VH 76 CDR1

<400>  26

Gly Tyr Thr Phe Thr Arg Tyr Trp Met His 
1               5                   10  


<210>  27
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide anti-CD100 VH 76 CDR2

<400>  27

Tyr Ile Asn Pro Ser Thr Gly Tyr Ser Asp Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  28
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide anti-CD100 VH 76 CDR3

<400>  28

Asp Pro Tyr Gly Trp Thr Met Asp Ser 
1               5                   


<210>  29
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide anti-CD100 VL 76

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  30
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide anti-CD100 VL 76 CDR1

<400>  30

His Ala Ser Gln Asn Ile Asn Val Trp Leu Ser 
1               5                   10      


<210>  31
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide anti-CD100 VL 76 CDR2

<400>  31

Lys Ala Ser Asn Leu His Thr 
1               5           


<210>  32
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide anti-CD100 VL 76 CDR3

<400>  32

Gln Gln Gly Gln Ser Tyr Pro Tyr Thr 
1               5                   


<210>  33
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  Polynucleotide anti-CD100 VH 76

<400>  33
caggtccagc tgcagcagtc tggggctgaa ctggcaaaac ctggggcctc agtgaagatg     60

tcctgcaagg cttctggcta cacctttact aggtactgga tgcactgggt aaaacagagg    120

cctggacagg gtctggaatg gattggatac attaatccta gcactggtta ttctgattac    180

aatcagaagt tcaaggacaa ggccacattg actgcagaca aatcctccag cacagcctac    240

atgcaactga gcagcctgac atctgaggac tctgcagtct attactgtgc aagagacccc    300

tacggctgga ctatggactc ctggggccaa gggactctgg tcaccgtctc ctca          354


<210>  34
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Polynucleotide anti-CD100 VH 76 CDR1

<400>  34
ggctacacct ttactaggta ctggatgcac                                      30


<210>  35
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  Polynucleotide anti-CD100 VH 76 CDR2

<400>  35
tacattaatc ctagcactgg ttattctgat tacaatcaga agttcaagga c              51


<210>  36
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Polynucleotide anti-CD100 VH 76 CDR3

<400>  36
gacccctacg gctggactat ggactcc                                         27


<210>  37
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Polynucleotide anti-CD100 VL 76

<400>  37
gacatccaga tgacccagtc tccatccagt ctgtctgcat cccttggaga cacaattacc     60

atcacttgcc atgccagtca gaacattaat gtttggttaa gctggtacca gcagaaacca    120

ggaaatattc ctaaactatt gatctataag gcttccaact tgcacacagg cgtcccatca    180

aggtttagtg gcagtggatc tggaacaggt ttcacattaa ccatcagcag cctgcagcct    240

gaagacattg ccacttacta ctgtcaacag ggtcaaagtt atccgtacac gttcggaggg    300

gggaccaagc tcgagatcaa a                                              321


<210>  38
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Polynucleotide anti-CD100 VL 76 CDR1

<400>  38
catgccagtc agaacattaa tgtttggtta agc                                  33


<210>  39
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Polynucleotide anti-CD100 VL 76 CDR2

<400>  39
aaggcttcca acttgcacac a                                               21


<210>  40
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Polynucleotide anti-CD100 VL 76 CDR3

<400>  40
caacagggtc aaagttatcc gtacacg                                         27