                         SEQUENCE LISTING

<110>  INOVIO PHARMACEUTICALS, INC.
       BRODERICK, Kate
       SARDESAI, Niranjan Y
       CASHMAN, Kathleen A
       SCHMALJOHN, Connie S
 
<120>  CROSS-PROTECTIVE ARENAVIRUS VACCINES AND THEIR METHOD OF USE

<130>  VGX0125

<150>  US 61/506579
<151>  2011-07-11

<150>  US 61/507062
<151>  2011-07-12

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LASV Josiah GP

<400>  1
atgggccaga tcgtgacctt cttccaggaa gtcccccacg tcatcgagga agtcatgaac       60

atcgtcctga tcgccctgtc cgtgctggcc gtgctgaagg gcctgtacaa cttcgccacc      120

tgtggcctgg tcggactggt caccttcctg ctgctgtgcg gccggtcctg caccacctcc      180

ctgtacaagg gcgtgtacga gctgcagacc ctggaactga acatggaaac cctgaacatg      240

accatgcccc tgagctgcac caagaacaac tcccaccact acatcatggt cggcaacgag      300

accggactgg aactgaccct gaccaacacc tccatcatca accacaagtt ctgcaacctg      360

tccgacgccc acaagaagaa cctgtacgac cacgccctga tgtccatcat ctccaccttc      420

cacctgtcca tccccaactt caaccagtac gaggccatgt cctgcgactt caacggcggc      480

aagatcagcg tgcagtacaa cctgtcccac tcctacgccg gcgacgccgc caaccactgc      540

ggcaccgtgg ccaacggcgt gctgcagacc ttcatgcgca tggcctgggg cggctcctac      600

atcgccctgg actccggcag gggcaactgg gactgcatca tgaccagcta ccagtacctg      660

atcatccaga acaccacctg ggaggaccac tgccagttct cccgcccctc ccccatcggc      720

tacctgggcc tgctgtccca gcgcacccgc gacatctaca tctcccgcag gctgctgggc      780

accttcacct ggaccctgtc cgactccgag ggcaaggaca cccctggcgg ctactgcctg      840

acccgctgga tgctgatcga ggccgagctg aagtgcttcg gcaacaccgc cgtggccaag      900

tgcaacgaga agcacgacga ggaattctgc gacatgctgc gcctgttcga cttcaacaag      960

caggccatcc agcgcctgaa ggccgaggcc cagatgtcta tccagctgat caacaaggcc     1020

gtgaacgccc tgatcaacga tcagctcatc atgaagaacc acctgaggga catcatgggc     1080

atcccttact gcaactactc caagtactgg tatctgaacc acaccaccac cggccgcacc     1140

tccctgccca agtgctggct ggtgtccaac ggctcctacc tgaacgagac ccacttctcc     1200

gacgacatcg agcagcaggc cgacaacatg atcaccgaga tgctgcagaa agaatacatg     1260

gaacgccaag gcaagacacc actgggcctg gtggacctgt tcgtgttctc cacctccttc     1320

tacctgatct ccatcttcct gcacctggtc aagatcccca cccaccgcca catcgtgggc     1380

aagtcctgcc ccaagcccca caggctgaac cacatgggca tctgcagctg cggactgtac     1440

aagcagcccg gcgtgcccgt gaagtggaag cgctga                               1476


<210>  2
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LASV Josiah NHP

<400>  2
atgggccaga tcgtgacctt ttttcaggaa gtgccccacg tcatcgagga agtgatgaac       60

atcgtcctga tcgccctgag cgtgctggcc gtgctgaagg gcctgtacaa ttttgccaca      120

tgcggcctgg tcggactggt cacatttctg ctgctgtgcg gcagaagctg cacaacaagc      180

ctgtacaagg gcgtgtacga gctgcagaca ctggaactga acatggaaac cctgaacatg      240

acaatgccac tgagctgcac caagaataac agccaccact acatcatggt cggcaatgag      300

acaggcctgg aactgacact gaccaacacc agcatcatca accacaagtt ctgcaatctg      360

agcgacgccc acaagaagaa tctgtacgac cacgccctga tgagcatcat cagcaccttt      420

cacctgagca tccccaactt taatcagtac gaggccatga gctgcgactt taatggcggc      480

aagatcagcg tgcagtacaa tctgagccac agctacgccg gcgacgccgc caatcactgc      540

ggcacagtgg ccaatggcgt gctgcagacc tttatgagaa tggcctgggg cggcagctat      600

atcgccctgg atagcggcag aggcaattgg gattgcatca tgaccagcta ccagtacctg      660

atcatccaga atacaacctg ggaggaccac tgccagttta gcagaccaag cccaatcggc      720

tacctgggcc tgctgtccca gagaacaagg gacatctaca tcagcagaag gctgctgggc      780

acctttacat ggacactgag cgatagcgag ggcaaggata caccaggcgg ctactgcctg      840

acaagatgga tgctgatcga ggccgagctg aagtgctttg gcaatacagc cgtggccaag      900

tgcaatgaga agcacgacga ggaattctgc gatatgctga ggctgttcga ctttaacaag      960

caggccatcc agagactgaa ggccgaggcc cagatgtcca tccagctgat caataaggcc     1020

gtgaacgccc tgatcaatga ccagctgatc atgaagaacc acctgagaga catcatgggc     1080

atcccatact gcaactacag caagtactgg tatctgaacc acacaacaac aggcagaaca     1140

agcctgccaa agtgctggct ggtgtccaat ggcagctacc tgaacgagac acactttagc     1200

gacgatatcg agcagcaggc cgacaatatg atcacagaga tgctgcagaa agaatacatg     1260

gaaaggcagg gcaagacacc actgggcctg gtggatctgt ttgtgttcag caccagcttc     1320

tacctgatca gcatctttct gcacctggtc aagatcccaa cacacagaca catcgtgggc     1380

aagagctgcc caaagccaca cagactgaac cacatgggca tctgcagctg cggcctgtat     1440

aagcagccag gcgtgccagt gaagtggaag agatga                               1476


<210>  3
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LASV ref gp2

<400>  3
atgggacaaa tagtgacatt cttccaggaa gtgcctcatg taatagaaga ggtgatgaac       60

attgttctca ttgcactgtc tgtactagca gtgctgaaag gtctgtacaa ttttgcaacg      120

tgtggccttg ttggtttggt cactttcctc ctgttgtgtg gtaggtcttg cacaaccagt      180

ctttataaag gggtttatga gcttcagact ctggaactaa acatggagac actcaatatg      240

accatgcctc tctcctgcac aaagaacaac agtcatcatt atataatggt gggcaatgag      300

acaggactag aactgagctt gaccaacacg agcattatta atcacaaatt ttgcaatctg      360

tctgatgccc acaaaaagaa cctctatgac cacgctctta tgagcataat ctcaactttc      420

cacttgtcca tccccaactt caatcagtat gaggcaatga gctgcgattt taatggggga      480

aagattagtg tgcagtacaa cctgagtcac agctatgctg gggatgcagc caaccattgt      540

ggtactgttg caaatggtgt gttacagact tttatgagga tggcttgggg tgggagctac      600

attgctcttg actcaggccg tggcaactgg gactgtatta tgactagtta tcaatatctg      660

ataatccaaa atacaacctg ggaagatcac tgccaattct cgagaccatc tcccatcggt      720

tatctcgggc tcctctcaca aaggactaga gatatttata ttagtagaag attgctaggc      780

acattcacat ggacactgtc agattctgaa ggtaaagaca caccaggggg atattgtctg      840

accaggtgga tgctaattga ggctgaacta aaatgcttcg ggaacacagc tgtggcaaaa      900

tgtaatgaga agcatgatga ggaattttgt gacatgctga ggctgtttga cttcaacaaa      960

caagccattc aaaggttgaa agctgaagca caaatgagca ttcagttgat caacaaagca     1020

gtaaatgctt tgataaatga ccaacttata atgaagaacc atctacggga catcatggga     1080

attccatact gtaattacag caagtattgg tacctcaacc acacaactac tgggagaaca     1140

tcactgccca aatgttggct tgtatcaaat ggttcatact tgaacgagac ccacttttct     1200

gatgatattg aacaacaagc tgacaatatg atcactgaga tgttacagaa ggagtatatg     1260

gagaggcagg ggaagacacc attgggtcta gttgacctct ttgtgttcag tacaagtttc     1320

tatcttatta gcatcttcct tcacctagtc aaaataccaa ctcataggca tattgtaggc     1380

aagtcgtgtc ccaaacctca cagattgaat catatgggca tttgttcctg tggactctac     1440

aaacagcctg gtgtgcctgt gaaatggaag agatga                               1476


<210>  4
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LASV Josiah GP (amino acid)

<400>  4

Met Gly Gln Ile Val Thr Phe Phe Gln Glu Val Pro His Val Ile Glu 
1               5                   10                  15      


Glu Val Met Asn Ile Val Leu Ile Ala Leu Ser Val Leu Ala Val Leu 
            20                  25                  30          


Lys Gly Leu Tyr Asn Phe Ala Thr Cys Gly Leu Val Gly Leu Val Thr 
        35                  40                  45              


Phe Leu Leu Leu Cys Gly Arg Ser Cys Thr Thr Ser Leu Tyr Lys Gly 
    50                  55                  60                  


Val Tyr Glu Leu Gln Thr Leu Glu Leu Asn Met Glu Thr Leu Asn Met 
65                  70                  75                  80  


Thr Met Pro Leu Ser Cys Thr Lys Asn Asn Ser His His Tyr Ile Met 
                85                  90                  95      


Val Gly Asn Glu Thr Gly Leu Glu Leu Thr Leu Thr Asn Thr Ser Ile 
            100                 105                 110         


Ile Asn His Lys Phe Cys Asn Leu Ser Asp Ala His Lys Lys Asn Leu 
        115                 120                 125             


Tyr Asp His Ala Leu Met Ser Ile Ile Ser Thr Phe His Leu Ser Ile 
    130                 135                 140                 


Pro Asn Phe Asn Gln Tyr Glu Ala Met Ser Cys Asp Phe Asn Gly Gly 
145                 150                 155                 160 


Lys Ile Ser Val Gln Tyr Asn Leu Ser His Ser Tyr Ala Gly Asp Ala 
                165                 170                 175     


Ala Asn His Cys Gly Thr Val Ala Asn Gly Val Leu Gln Thr Phe Met 
            180                 185                 190         


Arg Met Ala Trp Gly Gly Ser Tyr Ile Ala Leu Asp Ser Gly Arg Gly 
        195                 200                 205             


Asn Trp Asp Cys Ile Met Thr Ser Tyr Gln Tyr Leu Ile Ile Gln Asn 
    210                 215                 220                 


Thr Thr Trp Glu Asp His Cys Gln Phe Ser Arg Pro Ser Pro Ile Gly 
225                 230                 235                 240 


Tyr Leu Gly Leu Leu Ser Gln Arg Thr Arg Asp Ile Tyr Ile Ser Arg 
                245                 250                 255     


Arg Leu Leu Gly Thr Phe Thr Trp Thr Leu Ser Asp Ser Glu Gly Lys 
            260                 265                 270         


Asp Thr Pro Gly Gly Tyr Cys Leu Thr Arg Trp Met Leu Ile Glu Ala 
        275                 280                 285             


Glu Leu Lys Cys Phe Gly Asn Thr Ala Val Ala Lys Cys Asn Glu Lys 
    290                 295                 300                 


His Asp Glu Glu Phe Cys Asp Met Leu Arg Leu Phe Asp Phe Asn Lys 
305                 310                 315                 320 


Gln Ala Ile Gln Arg Leu Lys Ala Glu Ala Gln Met Ser Ile Gln Leu 
                325                 330                 335     


Ile Asn Lys Ala Val Asn Ala Leu Ile Asn Asp Gln Leu Ile Met Lys 
            340                 345                 350         


Asn His Leu Arg Asp Ile Met Gly Ile Pro Tyr Cys Asn Tyr Ser Lys 
        355                 360                 365             


Tyr Trp Tyr Leu Asn His Thr Thr Thr Gly Arg Thr Ser Leu Pro Lys 
    370                 375                 380                 


Cys Trp Leu Val Ser Asn Gly Ser Tyr Leu Asn Glu Thr His Phe Ser 
385                 390                 395                 400 


Asp Asp Ile Glu Gln Gln Ala Asp Asn Met Ile Thr Glu Met Leu Gln 
                405                 410                 415     


Lys Glu Tyr Met Glu Arg Gln Gly Lys Thr Pro Leu Gly Leu Val Asp 
            420                 425                 430         


Leu Phe Val Phe Ser Thr Ser Phe Tyr Leu Ile Ser Ile Phe Leu His 
        435                 440                 445             


Leu Val Lys Ile Pro Thr His Arg His Ile Val Gly Lys Ser Cys Pro 
    450                 455                 460                 


Lys Pro His Arg Leu Asn His Met Gly Ile Cys Ser Trp Gly Leu Tyr 
465                 470                 475                 480 


Lys Gln Pro Gly Val Pro Val Lys Trp Lys Arg 
                485                 490     


<210>  5
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LASV Josiah NHP (amino acid)

<400>  5

Met Gly Gln Ile Val Thr Phe Phe Gln Glu Val Pro His Val Ile Glu 
1               5                   10                  15      


Glu Val Met Asn Ile Val Leu Ile Ala Leu Ser Val Leu Ala Val Leu 
            20                  25                  30          


Lys Gly Leu Tyr Asn Phe Ala Thr Cys Gly Leu Val Gly Leu Val Thr 
        35                  40                  45              


Phe Leu Leu Leu Cys Gly Arg Ser Cys Thr Thr Ser Leu Tyr Lys Gly 
    50                  55                  60                  


Val Tyr Glu Leu Gln Thr Leu Glu Leu Asn Met Glu Thr Leu Asn Met 
65                  70                  75                  80  


Thr Met Pro Leu Ser Cys Thr Lys Asn Asn Ser His His Tyr Ile Met 
                85                  90                  95      


Val Gly Asn Glu Thr Gly Leu Glu Leu Thr Leu Thr Asn Thr Ser Ile 
            100                 105                 110         


Ile Asn His Lys Phe Cys Asn Leu Ser Asp Ala His Lys Lys Asn Leu 
        115                 120                 125             


Tyr Asp His Ala Leu Met Ser Ile Ile Ser Thr Phe His Leu Ser Ile 
    130                 135                 140                 


Pro Asn Phe Asn Gln Tyr Glu Ala Met Ser Cys Asp Phe Asn Gly Gly 
145                 150                 155                 160 


Lys Ile Ser Val Gln Tyr Asn Leu Ser His Ser Tyr Ala Gly Asp Ala 
                165                 170                 175     


Ala Asn His Cys Gly Thr Val Ala Asn Gly Val Leu Gln Thr Phe Met 
            180                 185                 190         


Arg Met Ala Trp Gly Gly Ser Tyr Ile Ala Leu Asp Ser Gly Arg Gly 
        195                 200                 205             


Asn Trp Asp Cys Ile Met Thr Ser Tyr Gln Tyr Leu Ile Ile Gln Asn 
    210                 215                 220                 


Thr Thr Trp Glu Asp His Cys Gln Phe Ser Arg Pro Ser Pro Ile Gly 
225                 230                 235                 240 


Tyr Leu Gly Leu Leu Ser Gln Arg Thr Arg Asp Ile Tyr Ile Ser Arg 
                245                 250                 255     


Arg Leu Leu Gly Thr Phe Thr Trp Thr Leu Ser Asp Ser Glu Gly Lys 
            260                 265                 270         


Asp Thr Pro Gly Gly Tyr Cys Leu Thr Arg Trp Met Leu Ile Glu Ala 
        275                 280                 285             


Glu Leu Lys Cys Phe Gly Asn Thr Ala Val Ala Lys Cys Asn Glu Lys 
    290                 295                 300                 


His Asp Glu Glu Phe Cys Asp Met Leu Arg Leu Phe Asp Phe Asn Lys 
305                 310                 315                 320 


Gln Ala Ile Gln Arg Leu Lys Ala Glu Ala Gln Met Ser Ile Gln Leu 
                325                 330                 335     


Ile Asn Lys Ala Val Asn Ala Leu Ile Asn Asp Gln Leu Ile Met Lys 
            340                 345                 350         


Asn His Leu Arg Asp Ile Met Gly Ile Pro Tyr Cys Asn Tyr Ser Lys 
        355                 360                 365             


Tyr Trp Tyr Leu Asn His Thr Thr Thr Gly Arg Thr Ser Leu Pro Lys 
    370                 375                 380                 


Cys Trp Leu Val Ser Asn Gly Ser Tyr Leu Asn Glu Thr His Phe Ser 
385                 390                 395                 400 


Asp Asp Ile Glu Gln Gln Ala Asp Asn Met Ile Thr Glu Met Leu Gln 
                405                 410                 415     


Lys Glu Tyr Met Glu Arg Gln Gly Lys Thr Pro Leu Gly Leu Val Asp 
            420                 425                 430         


Leu Phe Val Phe Ser Thr Ser Phe Tyr Leu Ile Ser Ile Phe Leu His 
        435                 440                 445             


Leu Val Lys Ile Pro Thr His Arg His Ile Val Gly Lys Ser Cys Pro 
    450                 455                 460                 


Lys Pro His Arg Leu Asn His Met Gly Ile Cys Ser Cys Gly Leu Tyr 
465                 470                 475                 480 


Lys Gln Pro Gly Val Pro Val Lys Trp Lys Arg 
                485                 490     


<210>  6
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LASV reference (amino acid)

<400>  6

Met Gly Gln Ile Val Thr Phe Phe Gln Glu Val Pro His Val Ile Glu 
1               5                   10                  15      


Glu Val Met Asn Ile Val Leu Ile Ala Leu Ser Val Leu Ala Val Leu 
            20                  25                  30          


Lys Gly Leu Tyr Asn Phe Ala Thr Cys Gly Leu Val Gly Leu Val Thr 
        35                  40                  45              


Phe Leu Leu Leu Cys Gly Arg Ser Cys Thr Thr Ser Leu Tyr Lys Gly 
    50                  55                  60                  


Val Tyr Glu Leu Gln Thr Leu Glu Leu Asn Met Glu Thr Leu Asn Met 
65                  70                  75                  80  


Thr Met Pro Leu Ser Cys Thr Lys Asn Asn Ser His His Tyr Ile Met 
                85                  90                  95      


Val Gly Asn Glu Thr Gly Leu Glu Leu Ser Leu Thr Asn Thr Ser Ile 
            100                 105                 110         


Ile Asn His Lys Phe Cys Asn Leu Ser Asp Ala His Lys Lys Asn Leu 
        115                 120                 125             


Tyr Asp His Ala Leu Met Ser Ile Ile Ser Thr Phe His Leu Ser Ile 
    130                 135                 140                 


Pro Asn Phe Asn Gln Tyr Glu Ala Met Ser Cys Asp Phe Asn Gly Gly 
145                 150                 155                 160 


Lys Ile Ser Val Gln Tyr Asn Leu Ser His Ser Tyr Ala Gly Asp Ala 
                165                 170                 175     


Ala Asn His Cys Gly Thr Val Ala Asn Gly Val Leu Gln Thr Phe Met 
            180                 185                 190         


Arg Met Ala Trp Gly Gly Ser Tyr Ile Ala Leu Asp Ser Gly Arg Gly 
        195                 200                 205             


Asn Trp Asp Cys Ile Met Thr Ser Tyr Gln Tyr Leu Ile Ile Gln Asn 
    210                 215                 220                 


Thr Thr Trp Glu Asp His Cys Gln Phe Ser Arg Pro Ser Pro Ile Gly 
225                 230                 235                 240 


Tyr Leu Gly Leu Leu Ser Gln Arg Thr Arg Asp Ile Tyr Ile Ser Arg 
                245                 250                 255     


Arg Leu Leu Gly Thr Phe Thr Trp Thr Leu Ser Asp Ser Glu Gly Lys 
            260                 265                 270         


Asp Thr Pro Gly Gly Tyr Cys Leu Thr Arg Trp Met Leu Ile Glu Ala 
        275                 280                 285             


Glu Leu Lys Cys Phe Gly Asn Thr Ala Val Ala Lys Cys Asn Glu Lys 
    290                 295                 300                 


His Asp Glu Glu Phe Cys Asp Met Leu Arg Leu Phe Asp Phe Asn Lys 
305                 310                 315                 320 


Gln Ala Ile Gln Arg Leu Lys Ala Glu Ala Gln Met Ser Ile Gln Leu 
                325                 330                 335     


Ile Asn Lys Ala Val Asn Ala Leu Ile Asn Asp Gln Leu Ile Met Lys 
            340                 345                 350         


Asn His Leu Arg Asp Ile Met Gly Ile Pro Tyr Cys Asn Tyr Ser Lys 
        355                 360                 365             


Tyr Trp Tyr Leu Asn His Thr Thr Thr Gly Arg Thr Ser Leu Pro Lys 
    370                 375                 380                 


Cys Trp Leu Val Ser Asn Gly Ser Tyr Leu Asn Glu Thr His Phe Ser 
385                 390                 395                 400 


Asp Asp Ile Glu Gln Gln Ala Asp Asn Met Ile Thr Glu Met Leu Gln 
                405                 410                 415     


Lys Glu Tyr Met Glu Arg Gln Gly Lys Thr Pro Leu Gly Leu Val Asp 
            420                 425                 430         


Val Phe Val Phe Ser Thr Ser Phe Tyr Leu Ile Ser Ile Phe Leu His 
        435                 440                 445             


Leu Val Lys Ile Pro Thr His Arg His Ile Val Gly Lys Ser Cys Pro 
    450                 455                 460                 


Lys Pro His Arg Leu Asn His Met Gly Ile Cys Ser Cys Gly Leu Tyr 
465                 470                 475                 480 


Lys Gln Pro Gly Val Pro Val Lys Trp Lys Arg 
                485                 490     


