                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       Weiner, David B
       Yan, Jian
 
<120>  VACCINES FOR HUMAN PAPILLOMA VIRUS AND METHODS FOR USING
        THE SAME

<130>  UPVG0025 WO2


<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  873
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPV6 E6E7 DNA sequence

<400>  1
ggtaccggat ccgccaccat ggactggacc tggattctgt tcctggtggc cgctgccaca       60

cgggtgcaca gcgaaagcgc caatgccagc accagcgcta caaccatcga ccagctgtgc      120

aagaccttca acctgagcat gcacaccctg cagatcaact gcgtgttctg caagaacgcc      180

ctgaccaccg ccgagatcta cagctacgcc tacaagcagc tgaaggtgct gttcagaggc      240

ggctacccct atgccgcctg cgcctgctgc ctggaatttc acggcaagat caaccagtac      300

cggcacttcg actacgccgg ctacgccacc accgtggaag aggaaacaaa gcaggacatc      360

ctggacgtgc tgatccggtg ctacctgtgc cacaagcccc tgtgcgaggt ggaaaaagtg      420

aagcacatcc tgaccaaggc ccggttcatc aagctgaact gcacctggaa gggccggtgc      480

ctgcactgct ggaccacctg tatggaagat atgctgccca gaggccggaa gcggcggagc      540

catggcagac acgtgaccct gaaggacatc gtgctggacc tgcagccccc cgatcctgtg      600

ggcctgcact gttacgagca gctggtggac agcagcgagg acgaggtgga cgaagtggac      660

ggccaggaca gccagcccct gaagcagcac ttccagatcg tgacctgctg ctgcggctgc      720

gacagcaacg tgcggctggt ggtgcagtgc accgagacag acatcagaga ggtccagcag      780

ctcctgctgg gcaccctgaa catcgtgtgc cccatctgcg cccccaagac ctacccttac      840

gacgtgcccg actacgcctg atgactcgag ctc                                   873


<210>  2
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV6 E6E7 protein sequence

<400>  2

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Glu Ser Ala Asn Ala Ser Thr Ser Ala Thr Thr Ile Asp Gln 
            20                  25                  30          


Leu Cys Lys Thr Phe Asn Leu Ser Met His Thr Leu Gln Ile Asn Cys 
        35                  40                  45              


Val Phe Cys Lys Asn Ala Leu Thr Thr Ala Glu Ile Tyr Ser Tyr Ala 
    50                  55                  60                  


Tyr Lys Gln Leu Lys Val Leu Phe Arg Gly Gly Tyr Pro Tyr Ala Ala 
65                  70                  75                  80  


Cys Ala Cys Cys Leu Glu Phe His Gly Lys Ile Asn Gln Tyr Arg His 
                85                  90                  95      


Phe Asp Tyr Ala Gly Tyr Ala Thr Thr Val Glu Glu Glu Thr Lys Gln 
            100                 105                 110         


Asp Ile Leu Asp Val Leu Ile Arg Cys Tyr Leu Cys His Lys Pro Leu 
        115                 120                 125             


Cys Glu Val Glu Lys Val Lys His Ile Leu Thr Lys Ala Arg Phe Ile 
    130                 135                 140                 


Lys Leu Asn Cys Thr Trp Lys Gly Arg Cys Leu His Cys Trp Thr Thr 
145                 150                 155                 160 


Cys Met Glu Asp Met Leu Pro Arg Gly Arg Lys Arg Arg Ser His Gly 
                165                 170                 175     


Arg His Val Thr Leu Lys Asp Ile Val Leu Asp Leu Gln Pro Pro Asp 
            180                 185                 190         


Pro Val Gly Leu His Cys Tyr Glu Gln Leu Val Asp Ser Ser Glu Asp 
        195                 200                 205             


Glu Val Asp Glu Val Asp Gly Gln Asp Ser Gln Pro Leu Lys Gln His 
    210                 215                 220                 


Phe Gln Ile Val Thr Cys Cys Cys Gly Cys Asp Ser Asn Val Arg Leu 
225                 230                 235                 240 


Val Val Gln Cys Thr Glu Thr Asp Ile Arg Glu Val Gln Gln Leu Leu 
                245                 250                 255     


Leu Gly Thr Leu Asn Ile Val Cys Pro Ile Cys Ala Pro Lys Thr Tyr 
            260                 265                 270         


Pro Tyr Asp Val Pro Asp Tyr Ala 
        275                 280 


<210>  3
<211>  873
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPV11 E6E7 DNA sequence

<400>  3
ggtaccggat ccgccaccat ggactggacc tggattctgt tcctggtggc cgctgccaca       60

agagtgcaca gcgagagcaa ggatgccagc accagcgcca ccagcatcga ccagctgtgc      120

aagaccttca acctgagcct gcacaccctg cagatccagt gcgtgttctg ccggaacgcc      180

ctgaccaccg ccgagatcta cgcctacgcc tacaagaacc tgaaggtcgt gtggcgggac      240

aacttcccct tcgccgcctg cgcctgctgc ctggaactgc agggcaagat caaccagtac      300

cggcacttca actacgccgc ttacgccccc accgtggaag aggaaacaaa cgaggacatc      360

ctgaaggtgc tgatccggtg ctacctgtgc cacaagcccc tgtgcgagat cgagaagctg      420

aagcacatcc tgggcaaggc ccggttcatc aagctgaaca accagtggaa gggccggtgc      480

ctgcactgct ggaccacctg tatggaagat ctgctgccca gaggccggaa gcggagaagc      540

cacggcagac tggtcaccct gaaggacatc gtgctggacc tgcagccccc cgatcctgtg      600

ggcctgcact gttacgagca gctggaagat agcagcgagg acgaggtgga caaagtggac      660

aagcaggacg cccagcccct gacccagcac taccagatcc tgacctgctg ctgcggctgc      720

gacagcaacg tgcggctggt ggtggaatgc accgacggcg acatccggca gctccaggat      780

ctgctgctgg gcaccctgaa catcgtgtgc cccatctgcg cccccaagcc ctacccctac      840

gacgtgcccg actacgcctg atgactcgag ctc                                   873


<210>  4
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV11 E6E7 protein sequence

<400>  4

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Glu Ser Lys Asp Ala Ser Thr Ser Ala Thr Ser Ile Asp Gln 
            20                  25                  30          


Leu Cys Lys Thr Phe Asn Leu Ser Leu His Thr Leu Gln Ile Gln Cys 
        35                  40                  45              


Val Phe Cys Arg Asn Ala Leu Thr Thr Ala Glu Ile Tyr Ala Tyr Ala 
    50                  55                  60                  


Tyr Lys Asn Leu Lys Val Val Trp Arg Asp Asn Phe Pro Phe Ala Ala 
65                  70                  75                  80  


Cys Ala Cys Cys Leu Glu Leu Gln Gly Lys Ile Asn Gln Tyr Arg His 
                85                  90                  95      


Phe Asn Tyr Ala Ala Tyr Ala Pro Thr Val Glu Glu Glu Thr Asn Glu 
            100                 105                 110         


Asp Ile Leu Lys Val Leu Ile Arg Cys Tyr Leu Cys His Lys Pro Leu 
        115                 120                 125             


Cys Glu Ile Glu Lys Leu Lys His Ile Leu Gly Lys Ala Arg Phe Ile 
    130                 135                 140                 


Lys Leu Asn Asn Gln Trp Lys Gly Arg Cys Leu His Cys Trp Thr Thr 
145                 150                 155                 160 


Cys Met Glu Asp Leu Leu Pro Arg Gly Arg Lys Arg Arg Ser His Gly 
                165                 170                 175     


Arg Leu Val Thr Leu Lys Asp Ile Val Leu Asp Leu Gln Pro Pro Asp 
            180                 185                 190         


Pro Val Gly Leu His Cys Tyr Glu Gln Leu Glu Asp Ser Ser Glu Asp 
        195                 200                 205             


Glu Val Asp Lys Val Asp Lys Gln Asp Ala Gln Pro Leu Thr Gln His 
    210                 215                 220                 


Tyr Gln Ile Leu Thr Cys Cys Cys Gly Cys Asp Ser Asn Val Arg Leu 
225                 230                 235                 240 


Val Val Glu Cys Thr Asp Gly Asp Ile Arg Gln Leu Gln Asp Leu Leu 
                245                 250                 255     


Leu Gly Thr Leu Asn Ile Val Cys Pro Ile Cys Ala Pro Lys Pro Tyr 
            260                 265                 270         


Pro Tyr Asp Val Pro Asp Tyr Ala 
        275                 280 


<210>  5
<211>  828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPV33 E6E7 DNA sequence

<400>  5
ggtaccgtcg acggatccgc caccatggac tggacctgga ttctgttcct ggtggccgct       60

gctacccggg tgcacagctt ccaggacacc gaggaaagcg gccggaccct gcacgatctg      120

tgccaggccc tggaaaccac catccacaac atcgagctgc agtgcgtgga atgcaagaag      180

cccctgcagc ggagcgaggt gtacgacgcc gacctgaccg tggtgtacag agagggcaac      240

cccttcggca tctgcaagct gtgcctgcgg ttcctgagca agatcagcga gtaccggcac      300

tacaactaca gcgtgtacgg caacaccctg gaacagaccg tgaagaagcc tctgaacgag      360

atcctgatcc ggtgcatcat ctgccagcgg cccctgaagc ggcacgtgga cctgaacaag      420

cggttccaca atatcagcgg cagatgggcc ggcagatgcg ccgcctgttg gagaagccgg      480

cggagagaga cagccctgcg gggcagaaag cggcggagca gaggccacaa gcccaccctg      540

aaagaatacg tgctggacct gtaccccgag cccaccgacc tgtacggcta cggccagctg      600

agcgacagca gcgacgagga cgagggcctg gacagacctg atggacaggc ccagcccgcc      660

accgccgact actacatcgt gacctgctgc cacacctgta acaccaccgt gcggctgtgc      720

gtgaacagca ccgccagcga cctgcggaca atccagcagc tcctgatggg caccgtgaac      780

atcgtgtgcc ctacctgcgc ccagctgtga ctcgagacgc gtgagctc                   828


<210>  6
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV33 E6E7 protein sequence

<400>  6

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Phe Gln Asp Thr Glu Glu Ser Gly Arg Thr Leu His Asp Leu 
            20                  25                  30          


Cys Gln Ala Leu Glu Thr Thr Ile His Asn Ile Glu Leu Gln Cys Val 
        35                  40                  45              


Glu Cys Lys Lys Pro Leu Gln Arg Ser Glu Val Tyr Asp Ala Asp Leu 
    50                  55                  60                  


Thr Val Val Tyr Arg Glu Gly Asn Pro Phe Gly Ile Cys Lys Leu Cys 
65                  70                  75                  80  


Leu Arg Phe Leu Ser Lys Ile Ser Glu Tyr Arg His Tyr Asn Tyr Ser 
                85                  90                  95      


Val Tyr Gly Asn Thr Leu Glu Gln Thr Val Lys Lys Pro Leu Asn Glu 
            100                 105                 110         


Ile Leu Ile Arg Cys Ile Ile Cys Gln Arg Pro Leu Lys Arg His Val 
        115                 120                 125             


Asp Leu Asn Lys Arg Phe His Asn Ile Ser Gly Arg Trp Ala Gly Arg 
    130                 135                 140                 


Cys Ala Ala Cys Trp Arg Ser Arg Arg Arg Glu Thr Ala Leu Arg Gly 
145                 150                 155                 160 


Arg Lys Arg Arg Ser Arg Gly His Lys Pro Thr Leu Lys Glu Tyr Val 
                165                 170                 175     


Leu Asp Leu Tyr Pro Glu Pro Thr Asp Leu Tyr Gly Tyr Gly Gln Leu 
            180                 185                 190         


Ser Asp Ser Ser Asp Glu Asp Glu Gly Leu Asp Arg Pro Asp Gly Gln 
        195                 200                 205             


Ala Gln Pro Ala Thr Ala Asp Tyr Tyr Ile Val Thr Cys Cys His Thr 
    210                 215                 220                 


Cys Asn Thr Thr Val Arg Leu Cys Val Asn Ser Thr Ala Ser Asp Leu 
225                 230                 235                 240 


Arg Thr Ile Gln Gln Leu Leu Met Gly Thr Val Asn Ile Val Cys Pro 
                245                 250                 255     


Thr Cys Ala Gln Leu 
            260     


<210>  7
<211>  835
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPV58 E6E7 DNA sequence

<400>  7
ggtaccgttt aaacggatcc gccaccatgg actggacctg gattctgttc ctggtggccg       60

ctgctacccg ggtgcacagc ttccaggatg ccgaggaaag cggccggacc ctgcacgatc      120

tgtgccaggc cctggaaacc agcgtgcacg agatcgagct gaagtgcgtg gaatgcaaga      180

aaaccctgca gcggagcgag gtgtacgacg ccgacctgcg gatcgtgtac cgggacggca      240

accccttcgc cgtgtgcaaa gtgtgcctgc ggctgctgag caagatcagc gagtaccggc      300

actacaacta cagcctgtac ggcgacaccc tggaacagac cctgaagaag tgcctgaacg      360

agatcctgat ccggtgcatc atctgccagc ggcccctgaa gcggcacgtg gacctgaaca      420

agcggttcca caacatcagc ggccggtgga ccggcagatg cgccgtgtgt tggaggccca      480

ggcggagaca gacccaggtg cgcggcagaa agcggcggag cagaggcaac aaccccaccc      540

tgagagagta catcctggac ctgcaccccg agcccaccga cctgtttggc tacggccagc      600

tgtgcgacag cagcgacgag gacgagatcg gcctggacgg ccctgatgga caggcccagc      660

ccgccaccgc caactactac atcgtgacct gctgctacac ctgtggcacc accgtgcggc      720

tgtgcatcaa cagcaccacc accgacgtgc gcaccctgca gcagctcctg atgggcacct      780

gtaccatcgt gtgccccagc tgcgcccagc agtgactcga ggcggccgcg agctc           835


<210>  8
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV58 E6E7 protein sequence

<400>  8

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Phe Gln Asp Ala Glu Glu Ser Gly Arg Thr Leu His Asp Leu 
            20                  25                  30          


Cys Gln Ala Leu Glu Thr Ser Val His Glu Ile Glu Leu Lys Cys Val 
        35                  40                  45              


Glu Cys Lys Lys Thr Leu Gln Arg Ser Glu Val Tyr Asp Ala Asp Leu 
    50                  55                  60                  


Arg Ile Val Tyr Arg Asp Gly Asn Pro Phe Ala Val Cys Lys Val Cys 
65                  70                  75                  80  


Leu Arg Leu Leu Ser Lys Ile Ser Glu Tyr Arg His Tyr Asn Tyr Ser 
                85                  90                  95      


Leu Tyr Gly Asp Thr Leu Glu Gln Thr Leu Lys Lys Cys Leu Asn Glu 
            100                 105                 110         


Ile Leu Ile Arg Cys Ile Ile Cys Gln Arg Pro Leu Lys Arg His Val 
        115                 120                 125             


Asp Leu Asn Lys Arg Phe His Asn Ile Ser Gly Arg Trp Thr Gly Arg 
    130                 135                 140                 


Cys Ala Val Cys Trp Arg Pro Arg Arg Arg Gln Thr Gln Val Arg Gly 
145                 150                 155                 160 


Arg Lys Arg Arg Ser Arg Gly Asn Asn Pro Thr Leu Arg Glu Tyr Ile 
                165                 170                 175     


Leu Asp Leu His Pro Glu Pro Thr Asp Leu Phe Gly Tyr Gly Gln Leu 
            180                 185                 190         


Cys Asp Ser Ser Asp Glu Asp Glu Ile Gly Leu Asp Gly Pro Asp Gly 
        195                 200                 205             


Gln Ala Gln Pro Ala Thr Ala Asn Tyr Tyr Ile Val Thr Cys Cys Tyr 
    210                 215                 220                 


Thr Cys Gly Thr Thr Val Arg Leu Cys Ile Asn Ser Thr Thr Thr Asp 
225                 230                 235                 240 


Val Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Cys Thr Ile Val Cys 
                245                 250                 255     


Pro Ser Cys Ala Gln Gln 
            260         


<210>  9
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgE Leader DNA sequence

<400>  9
atggactgga cctggatcct gttcctggtg gccgctgcca cacgggtgca cagc             54


<210>  10
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE leader protein

<400>  10

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser 
        


<210>  11
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV6 peptide 7

<400>  11

Thr Ala Glu Ile Tyr Ser Tyr Ala Tyr Lys Gln Leu Lys Val Leu 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV11 peptide 7

<400>  12

Thr Ala Glu Ile Tyr Ala Tyr Ala Tyr Lys Asn Leu Lys Val Val 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV11 peptide 27

<400>  13

His Cys Tyr Glu Gln Leu Glu Asp Ser Ser Glu Asp Glu Val Asp 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV subdominant peptide 6

<400>  14

Phe Cys Lys Asn Ala Leu Thr Thr Ala Glu Ile Tyr Ser Tyr Ala 
1               5                   10                  15  


<210>  15
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV subdominant peptide 9

<400>  15

Leu Phe Arg Gly Gly Tyr Pro Tyr Ala Ala Cys Ala Cys Cys Leu 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV subdominant peptide 13

<400>  16

Tyr Ala Gly Tyr Ala Thr Thr Val Glu Glu Glu Thr Lys Gln Asp 
1               5                   10                  15  


