                         SEQUENCE LISTING

<110>  Yeda Research and Development Co. Ltd.
 
<120>  TOLL-LIKE RECEPTOR 4 (TLR-4) AGONIST PEPTIDES FOR MODULATING 
       TLR-4 MEDIATED IMMUNE RESPONSE

<130>  YEDA/090 PCT

<150>  US 61/545,222
<151>  2011-10-10

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  1

Thr Ile Ile Gly Val Ser Val Leu Ser Val Leu Val Val Ser Val Val 
1               5                   10                  15      


Ala Val Leu Val Tyr Lys Phe Tyr Phe His Leu Met Leu Ile 
            20                  25                  30  


<210>  2
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = Gly, Ser, Gln or Ala

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa = Ser, Gln or Ala

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa = Ser, Gln or Ala

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = Ser, Gln or Ala

<400>  2

Thr Ile Ile Xaa Val Xaa Val Leu Xaa Val Leu Val Val Xaa Val Val 
1               5                   10                  15      


<210>  3
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  3

Ser Val Leu Val Val Ser Val Val Ala Val Leu Val Tyr Lys Phe Tyr 
1               5                   10                  15      


<210>  4
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Xaa = Val or Lys

<400>  4

Xaa Xaa Ala Val Leu Val Tyr Lys Phe Tyr Phe His Leu Met Leu Ile 
1               5                   10                  15      


<210>  5
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  5

Thr Ile Ile Gly Val Ser Val Leu Ser Val Leu Val Val Ser Val Val 
1               5                   10                  15      


<210>  6
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  6

Thr Ile Ile Gly Val Gln Val Val Gln Val Ile Val Val Ser Val Val 
1               5                   10                  15      


<210>  7
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  7

Thr Ile Ile Gln Val Gln Val Val Gln Val Ile Val Val Gln Val Val 
1               5                   10                  15      


<210>  8
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  8

Thr Ile Ile Gln Val Gln Val Val Gln Val Ile Val Val Ser Val Val 
1               5                   10                  15      


<210>  9
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  9

Thr Ile Ile Gly Val Gln Val Val Gln Val Ile Val Val Gln Val Val 
1               5                   10                  15      


<210>  10
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  10

Thr Ile Ile Gln Val Ser Val Val Ser Val Ile Val Val Gln Val Val 
1               5                   10                  15      


<210>  11
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  11

Thr Ile Ile Ala Val Ala Val Val Ala Val Ile Val Val Ala Val Val 
1               5                   10                  15      


<210>  12
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  12

Val Val Ala Val Leu Val Tyr Lys Phe Tyr Phe His Leu Met Leu Ile 
1               5                   10                  15      


<210>  13
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  13

Thr Ile Ile Gly Val Ser Val Val Ser Val Ile Val 
1               5                   10          


<210>  14
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  14

Thr Ile Ile Gly Val Gln Val Val Gln Val Ile Val 
1               5                   10          


<210>  15
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  15

Lys Lys Thr Ile Ile Gly Val Ser Val Val Ser Val Ile Val Val Ser 
1               5                   10                  15      


Val Val 
        


<210>  16
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  16

Lys Lys Thr Ile Ile Gly Val Gln Val Val Gln Val Ile Val Val Ser 
1               5                   10                  15      


Val Val 
        


<210>  17
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  17

Lys Lys Thr Ile Ile Gly Val Ala Val Val Ala Val Ile Val Val Ser 
1               5                   10                  15      


Val Val 
        


<210>  18
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  18

Lys Lys Thr Ile Ile Gly Val Ser Val Val Ser Val Ile Val 
1               5                   10                  


<210>  19
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  19

Lys Lys Thr Ile Ile Gly Val Gln Val Val Gln Val Ile Val 
1               5                   10                  


<210>  20
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  20

Lys Lys Ala Val Leu Val Tyr Lys Phe Tyr Phe His Leu Met Leu Ile 
1               5                   10                  15      


<210>  21
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  D-Thr

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  D-Val

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  D-Val

<400>  21

Lys Lys Thr Ile Ile Gly Val Ser Val Val Ser Val Ile Val 
1               5                   10                  


<210>  22
<211>  30
<212>  PRT
<213>  Mus musculus

<400>  22

Thr Ile Ile Ser Val Ser Val Val Ser Val Ile Val Val Ser Thr Val 
1               5                   10                  15      


Ala Phe Leu Ile Tyr His Phe Tyr Phe His Leu Ile Leu Ile 
            20                  25                  30  


<210>  23
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  23

Thr Ile Ile Ser Val Ser Val Val Ser Val Ile Val Val Ser Thr Val 
1               5                   10                  15      


<210>  24
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  24

Ser Val Ile Val Val Ser Thr Val Ala Phe Leu Ile Tyr His Phe Tyr 
1               5                   10                  15      


<210>  25
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  25

Thr Val Ala Phe Leu Ile Tyr His Phe Tyr Phe His Leu Ile Leu Ile 
1               5                   10                  15      


<210>  26
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  26

Thr Ile Ile Ser Val Gln Val Val Gln Val Ile Val Val Ser Thr Val 
1               5                   10                  15      


<210>  27
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  27

Thr Ile Ile Gln Val Gln Val Val Gln Val Ile Val Val Gln Thr Val 
1               5                   10                  15      


<210>  28
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  28

Thr Ile Ile Gln Val Gln Val Val Gln Val Ile Val Val Ser Thr Val 
1               5                   10                  15      


<210>  29
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  29

Thr Ile Ile Ser Val Gln Val Val Gln Val Ile Val Val Gln Thr Val 
1               5                   10                  15      


<210>  30
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  30

Thr Ile Ile Gln Val Ser Val Val Ser Val Ile Val Val Gln Thr Val 
1               5                   10                  15      


<210>  31
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  31

Thr Ile Ile Ser Val Ala Val Val Ala Val Ile Val Val Ser Thr Val 
1               5                   10                  15      


<210>  32
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  32

Thr Ile Ile Ala Val Ala Val Val Ala Val Ile Val Val Ala Thr Val 
1               5                   10                  15      


<210>  33
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  33

Ala Ile Ile Ala Val Ala Val Val Ala Val Ile Val Val Ala Ala Val 
1               5                   10                  15      


<210>  34
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  34

Thr Ile Ile Ser Val Gly Val Val Gly Val Ile Val Val Ser Thr Val 
1               5                   10                  15      


<210>  35
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  35

Thr Ile Ile Gly Val Gly Val Val Gly Val Ile Val Val Gly Thr Val 
1               5                   10                  15      


<210>  36
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  36

Thr Ile Ile Ser Leu Ser Leu Leu Ser Leu Ile Leu Leu Ser Thr Leu 
1               5                   10                  15      


<210>  37
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  37

Lys Lys Thr Ile Ile Ser Val Ser Val Val Ser Val Ile Val Val Ser 
1               5                   10                  15      


Thr Val Lys Lys 
            20  


<210>  38
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  38

Lys Lys Thr Ile Ile Ser Val Gln Val Val Gln Val Ile Val Val Ser 
1               5                   10                  15      


Thr Val Lys Lys 
            20  


<210>  39
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  39

Lys Lys Thr Ile Ile Ser Val Ala Val Val Ala Val Ile Val Val Ser 
1               5                   10                  15      


Thr Val Lys Lys 
            20  


<210>  40
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  40

Lys Lys Thr Ile Ile Ser Val Ser Val Val Ser Val Ile Val 
1               5                   10                  


<210>  41
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  41

Lys Lys Ser Val Ile Val Val Ser Thr Val Ala Phe Leu Ile 
1               5                   10                  


<210>  42
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  42

Lys Lys Ala Phe Leu Ile Tyr His Phe Tyr Phe His Leu Ile 
1               5                   10                  


<210>  43
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  43

Lys Lys Thr Leu Leu Ser Val Ser Val Val Ser Val Leu Val 
1               5                   10                  


<210>  44
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  D-Thr

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  D-Val

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  D-Val

<400>  44

Lys Lys Thr Ile Ile Ser Val Ser Val Val Ser Val Ile Val 
1               5                   10                  


<210>  45
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  45

Lys Lys Thr Ile Ile Ser Val Gln Val Val Gln Val Ile Val 
1               5                   10                  


<210>  46
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  46

Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


<210>  47
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  47

Ile Thr Leu Ile Ile Phe Gly Val Met Ala Gly Val Ile Gly Thr 
1               5                   10                  15  


<210>  48
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Met Ser Ala Ser Arg Leu Ala Gly Thr Leu Ile Pro Ala Met Ala 
1               5                   10                  15      


Phe Leu Ser Cys Val Arg Pro Glu Ser Trp Glu Pro Cys Val Glu Val 
            20                  25                  30          


Val Pro Asn Ile Thr Tyr Gln Cys Met Glu Leu Asn Phe Tyr Lys Ile 
        35                  40                  45              


Pro Asp Asn Leu Pro Phe Ser Thr Lys Asn Leu Asp Leu Ser Phe Asn 
    50                  55                  60                  


Pro Leu Arg His Leu Gly Ser Tyr Ser Phe Phe Ser Phe Pro Glu Leu 
65                  70                  75                  80  


Gln Val Leu Asp Leu Ser Arg Cys Glu Ile Gln Thr Ile Glu Asp Gly 
                85                  90                  95      


Ala Tyr Gln Ser Leu Ser His Leu Ser Thr Leu Ile Leu Thr Gly Asn 
            100                 105                 110         


Pro Ile Gln Ser Leu Ala Leu Gly Ala Phe Ser Gly Leu Ser Ser Leu 
        115                 120                 125             


Gln Lys Leu Val Ala Val Glu Thr Asn Leu Ala Ser Leu Glu Asn Phe 
    130                 135                 140                 


Pro Ile Gly His Leu Lys Thr Leu Lys Glu Leu Asn Val Ala His Asn 
145                 150                 155                 160 


Leu Ile Gln Ser Phe Lys Leu Pro Glu Tyr Phe Ser Asn Leu Thr Asn 
                165                 170                 175     


Leu Glu His Leu Asp Leu Ser Ser Asn Lys Ile Gln Ser Ile Tyr Cys 
            180                 185                 190         


Thr Asp Leu Arg Val Leu His Gln Met Pro Leu Leu Asn Leu Ser Leu 
        195                 200                 205             


Asp Leu Ser Leu Asn Pro Met Asn Phe Ile Gln Pro Gly Ala Phe Lys 
    210                 215                 220                 


Glu Ile Arg Leu His Lys Leu Thr Leu Arg Asn Asn Phe Asp Ser Leu 
225                 230                 235                 240 


Asn Val Met Lys Thr Cys Ile Gln Gly Leu Ala Gly Leu Glu Val His 
                245                 250                 255     


Arg Leu Val Leu Gly Glu Phe Arg Asn Glu Gly Asn Leu Glu Lys Phe 
            260                 265                 270         


Asp Lys Ser Ala Leu Glu Gly Leu Cys Asn Leu Thr Ile Glu Glu Phe 
        275                 280                 285             


Arg Leu Ala Tyr Leu Asp Tyr Tyr Leu Asp Asp Ile Ile Asp Leu Phe 
    290                 295                 300                 


Asn Cys Leu Thr Asn Val Ser Ser Phe Ser Leu Val Ser Val Thr Ile 
305                 310                 315                 320 


Glu Arg Val Lys Asp Phe Ser Tyr Asn Phe Gly Trp Gln His Leu Glu 
                325                 330                 335     


Leu Val Asn Cys Lys Phe Gly Gln Phe Pro Thr Leu Lys Leu Lys Ser 
            340                 345                 350         


Leu Lys Arg Leu Thr Phe Thr Ser Asn Lys Gly Gly Asn Ala Phe Ser 
        355                 360                 365             


Glu Val Asp Leu Pro Ser Leu Glu Phe Leu Asp Leu Ser Arg Asn Gly 
    370                 375                 380                 


Leu Ser Phe Lys Gly Cys Cys Ser Gln Ser Asp Phe Gly Thr Thr Ser 
385                 390                 395                 400 


Leu Lys Tyr Leu Asp Leu Ser Phe Asn Gly Val Ile Thr Met Ser Ser 
                405                 410                 415     


Asn Phe Leu Gly Leu Glu Gln Leu Glu His Leu Asp Phe Gln His Ser 
            420                 425                 430         


Asn Leu Lys Gln Met Ser Glu Phe Ser Val Phe Leu Ser Leu Arg Asn 
        435                 440                 445             


Leu Ile Tyr Leu Asp Ile Ser His Thr His Thr Arg Val Ala Phe Asn 
    450                 455                 460                 


Gly Ile Phe Asn Gly Leu Ser Ser Leu Glu Val Leu Lys Met Ala Gly 
465                 470                 475                 480 


Asn Ser Phe Gln Glu Asn Phe Leu Pro Asp Ile Phe Thr Glu Leu Arg 
                485                 490                 495     


Asn Leu Thr Phe Leu Asp Leu Ser Gln Cys Gln Leu Glu Gln Leu Ser 
            500                 505                 510         


Pro Thr Ala Phe Asn Ser Leu Ser Ser Leu Gln Val Leu Asn Met Ser 
        515                 520                 525             


His Asn Asn Phe Phe Ser Leu Asp Thr Phe Pro Tyr Lys Cys Leu Asn 
    530                 535                 540                 


Ser Leu Gln Val Leu Asp Tyr Ser Leu Asn His Ile Met Thr Ser Lys 
545                 550                 555                 560 


Lys Gln Glu Leu Gln His Phe Pro Ser Ser Leu Ala Phe Leu Asn Leu 
                565                 570                 575     


Thr Gln Asn Asp Phe Ala Cys Thr Cys Glu His Gln Ser Phe Leu Gln 
            580                 585                 590         


Trp Ile Lys Asp Gln Arg Gln Leu Leu Val Glu Val Glu Arg Met Glu 
        595                 600                 605             


Cys Ala Thr Pro Ser Asp Lys Gln Gly Met Pro Val Leu Ser Leu Asn 
    610                 615                 620                 


Ile Thr Cys Gln Met Asn Lys Thr Ile Ile Gly Val Ser Val Leu Ser 
625                 630                 635                 640 


Val Leu Val Val Ser Val Val Ala Val Leu Val Tyr Lys Phe Tyr Phe 
                645                 650                 655     


His Leu Met Leu Leu Ala Gly Cys Ile Lys Tyr Gly Arg Gly Glu Asn 
            660                 665                 670         


Ile Tyr Asp Ala Phe Val Ile Tyr Ser Ser Gln Asp Glu Asp Trp Val 
        675                 680                 685             


Arg Asn Glu Leu Val Lys Asn Leu Glu Glu Gly Val Pro Pro Phe Gln 
    690                 695                 700                 


Leu Cys Leu His Tyr Arg Asp Phe Ile Pro Gly Val Ala Ile Ala Ala 
705                 710                 715                 720 


Asn Ile Ile His Glu Gly Phe His Lys Ser Arg Lys Val Ile Val Val 
                725                 730                 735     


Val Ser Gln His Phe Ile Gln Ser Arg Trp Cys Ile Phe Glu Tyr Glu 
            740                 745                 750         


Ile Ala Gln Thr Trp Gln Phe Leu Ser Ser Arg Ala Gly Ile Ile Phe 
        755                 760                 765             


Ile Val Leu Gln Lys Val Glu Lys Thr Leu Leu Arg Gln Gln Val Glu 
    770                 775                 780                 


Leu Tyr Arg Leu Leu Ser Arg Asn Thr Tyr Leu Glu Trp Glu Asp Ser 
785                 790                 795                 800 


Val Leu Gly Arg His Ile Phe Trp Arg Arg Leu Arg Lys Ala Leu Leu 
                805                 810                 815     


Asp Gly Lys Ser Trp Asn Pro Glu Gly Thr Val Gly Thr Gly Cys Asn 
            820                 825                 830         


Trp Gln Glu Ala Thr Ser Ile 
        835                 


<210>  49
<211>  835
<212>  PRT
<213>  Mus musculus

<400>  49

Met Met Pro Pro Trp Leu Leu Ala Arg Thr Leu Ile Met Ala Leu Phe 
1               5                   10                  15      


Phe Ser Cys Leu Thr Pro Gly Ser Leu Asn Pro Cys Ile Glu Val Val 
            20                  25                  30          


Pro Asn Ile Thr Tyr Gln Cys Met Asp Gln Lys Leu Ser Lys Val Pro 
        35                  40                  45              


Asp Asp Ile Pro Ser Ser Thr Lys Asn Ile Asp Leu Ser Phe Asn Pro 
    50                  55                  60                  


Leu Lys Ile Leu Lys Ser Tyr Ser Phe Ser Asn Phe Ser Glu Leu Gln 
65                  70                  75                  80  


Trp Leu Asp Leu Ser Arg Cys Glu Ile Glu Thr Ile Glu Asp Lys Ala 
                85                  90                  95      


Trp His Gly Leu His His Leu Ser Asn Leu Ile Leu Thr Gly Asn Pro 
            100                 105                 110         


Ile Gln Ser Phe Ser Pro Gly Ser Phe Ser Gly Leu Thr Ser Leu Glu 
        115                 120                 125             


Asn Leu Val Ala Val Glu Thr Lys Leu Ala Ser Leu Glu Ser Phe Pro 
    130                 135                 140                 


Ile Gly Gln Leu Ile Thr Leu Lys Lys Leu Asn Val Ala His Asn Phe 
145                 150                 155                 160 


Ile His Ser Cys Lys Leu Pro Ala Tyr Phe Ser Asn Leu Thr Asn Leu 
                165                 170                 175     


Val His Val Asp Leu Ser Tyr Asn Tyr Ile Gln Thr Ile Thr Val Asn 
            180                 185                 190         


Asp Leu Gln Phe Leu Arg Glu Asn Pro Gln Val Asn Leu Ser Leu Asp 
        195                 200                 205             


Met Ser Leu Asn Pro Ile Asp Phe Ile Gln Asp Gln Ala Phe Gln Gly 
    210                 215                 220                 


Ile Lys Leu His Glu Leu Thr Leu Arg Gly Asn Phe Asn Ser Ser Asn 
225                 230                 235                 240 


Ile Met Lys Thr Cys Leu Gln Asn Leu Ala Gly Leu His Val His Arg 
                245                 250                 255     


Leu Ile Leu Gly Glu Phe Lys Asp Glu Arg Asn Leu Glu Ile Phe Glu 
            260                 265                 270         


Pro Ser Ile Met Glu Gly Leu Cys Asp Val Thr Ile Asp Glu Phe Arg 
        275                 280                 285             


Leu Thr Tyr Thr Asn Asp Phe Ser Asp Asp Ile Val Lys Phe His Cys 
    290                 295                 300                 


Leu Ala Asn Val Ser Ala Met Ser Leu Ala Gly Val Ser Ile Lys Tyr 
305                 310                 315                 320 


Leu Glu Asp Val Pro Lys His Phe Lys Trp Gln Ser Leu Ser Ile Ile 
                325                 330                 335     


Arg Cys Gln Leu Lys Gln Phe Pro Thr Leu Asp Leu Pro Phe Leu Lys 
            340                 345                 350         


Ser Leu Thr Leu Thr Met Asn Lys Gly Ser Ile Ser Phe Lys Lys Val 
        355                 360                 365             


Ala Leu Pro Ser Leu Ser Tyr Leu Asp Leu Ser Arg Asn Ala Leu Ser 
    370                 375                 380                 


Phe Ser Gly Cys Cys Ser Tyr Ser Asp Leu Gly Thr Asn Ser Leu Arg 
385                 390                 395                 400 


His Leu Asp Leu Ser Phe Asn Gly Ala Ile Ile Met Ser Ala Asn Phe 
                405                 410                 415     


Met Gly Leu Glu Glu Leu Gln His Leu Asp Phe Gln His Ser Thr Leu 
            420                 425                 430         


Lys Arg Val Thr Glu Phe Ser Ala Phe Leu Ser Leu Glu Lys Leu Leu 
        435                 440                 445             


Tyr Leu Asp Ile Ser Tyr Thr Asn Thr Lys Ile Asp Phe Asp Gly Ile 
    450                 455                 460                 


Phe Leu Gly Leu Thr Ser Leu Asn Thr Leu Lys Met Ala Gly Asn Ser 
465                 470                 475                 480 


Phe Lys Asp Asn Thr Leu Ser Asn Val Phe Ala Asn Thr Thr Asn Leu 
                485                 490                 495     


Thr Phe Leu Asp Leu Ser Lys Cys Gln Leu Glu Gln Ile Ser Trp Gly 
            500                 505                 510         


Val Phe Asp Thr Leu His Arg Leu Gln Leu Leu Asn Met Ser His Asn 
        515                 520                 525             


Asn Leu Leu Phe Leu Asp Ser Ser His Tyr Asn Gln Leu Tyr Ser Leu 
    530                 535                 540                 


Ser Thr Leu Asp Cys Ser Phe Asn Arg Ile Glu Thr Ser Lys Gly Ile 
545                 550                 555                 560 


Leu Gln His Phe Pro Lys Ser Leu Ala Phe Phe Asn Leu Thr Asn Asn 
                565                 570                 575     


Ser Val Ala Cys Ile Cys Glu His Gln Lys Phe Leu Gln Trp Val Lys 
            580                 585                 590         


Glu Gln Lys Gln Phe Leu Val Asn Val Glu Gln Met Thr Cys Ala Thr 
        595                 600                 605             


Pro Val Glu Met Asn Thr Ser Leu Val Leu Asp Phe Asn Asn Ser Thr 
    610                 615                 620                 


Cys Tyr Met Tyr Lys Thr Ile Ile Ser Val Ser Val Val Ser Val Ile 
625                 630                 635                 640 


Val Val Ser Thr Val Ala Phe Leu Ile Tyr His Phe Tyr Phe His Leu 
                645                 650                 655     


Ile Leu Ile Ala Gly Cys Lys Lys Tyr Ser Arg Gly Glu Ser Ile Tyr 
            660                 665                 670         


Asp Ala Phe Val Ile Tyr Ser Ser Gln Asn Glu Asp Trp Val Arg Asn 
        675                 680                 685             


Glu Leu Val Lys Asn Leu Glu Glu Gly Val Pro Arg Phe His Leu Cys 
    690                 695                 700                 


Leu His Tyr Arg Asp Phe Ile Pro Gly Val Ala Ile Ala Ala Asn Ile 
705                 710                 715                 720 


Ile Gln Glu Gly Phe His Lys Ser Arg Lys Val Ile Val Val Val Ser 
                725                 730                 735     


Arg His Phe Ile Gln Ser Arg Trp Cys Ile Phe Glu Tyr Glu Ile Ala 
            740                 745                 750         


Gln Thr Trp Gln Phe Leu Ser Ser Arg Ser Gly Ile Ile Phe Ile Val 
        755                 760                 765             


Leu Glu Lys Val Glu Lys Ser Leu Leu Arg Gln Gln Val Glu Leu Tyr 
    770                 775                 780                 


Arg Leu Leu Ser Arg Asn Thr Tyr Leu Glu Trp Glu Asp Asn Pro Leu 
785                 790                 795                 800 


Gly Arg His Ile Phe Trp Arg Arg Leu Lys Asn Ala Leu Leu Asp Gly 
                805                 810                 815     


Lys Ala Ser Asn Pro Glu Gln Thr Ala Glu Glu Glu Gln Glu Thr Ala 
            820                 825                 830         


Thr Trp Thr 
        835 


<210>  50
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  50

Lys Lys Thr Ile Ile Gly Val Ser Val Val Ser Val Ile Val Val Ser 
1               5                   10                  15      


Val Val Lys Lys 
            20  


<210>  51
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  51

Lys Lys Thr Ile Ile Gly Val Gln Val Val Gln Val Ile Val Val Ser 
1               5                   10                  15      


Val Val Lys Lys 
            20  


<210>  52
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  52

Lys Lys Thr Ile Ile Gly Val Ala Val Val Ala Val Ile Val Val Ser 
1               5                   10                  15      


Val Val Lys Lys 
            20  


<210>  53
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Sythetic peptide

<400>  53

Thr Ile Ile Ser Ala Ser Ala Ala Ser Ala Ile Ala Ala Ser Thr Ala 
1               5                   10                  15      


<210>  54
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  54

Thr Ile Ile Ser Ala Ala Ala Ala Ala Ala Ile Ala Ala Ser Thr Ala 
1               5                   10                  15      


