                         SEQUENCE LISTING

<110>  NVIP Pty Ltd
 
<120>  CANINE/FELINE CD20 BINDING EPITOPE AND COMPOSITIONS FOR BINDING 
       THERETO

<130>  P121614.WO.01

<150>  US 61/546,865
<151>  2011-10-13

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Canis familiaris

<400>  1

Pro Ser Glu Lys Asn Ser Leu 
1               5           


<210>  2
<211>  20
<212>  PRT
<213>  Canis familiaris

<400>  2

Ile His Asn Cys Asp Pro Ala Asn Pro Ser Glu Lys Asn Ser Leu Ser 
1               5                   10                  15      


Ile Gln Tyr Cys 
            20  


<210>  3
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  3

Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn Ser Pro Ser 
1               5                   10                  15      


Thr Gln Tyr Cys 
            20  


<210>  4
<211>  21
<212>  PRT
<213>  Felis catus

<400>  4

Ile His Thr Cys Gln Pro Glu Ser Lys Pro Ser Glu Lys Asn Ser Leu 
1               5                   10                  15      


Ser Ile Lys Tyr Cys 
            20      


<210>  5
<211>  20
<212>  PRT
<213>  Equus caballus

<400>  5

Ile Tyr Asn Cys Glu Ser Ala Asn Pro Ala Glu Arg Asn Thr Leu Ser 
1               5                   10                  15      


Ile Lys Tyr Cys 
            20  


<210>  6
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  6

Ile Tyr Asp Cys Glu Pro Ser Asn Ser Ser Glu Lys Asn Ser Pro Ser 
1               5                   10                  15      


Thr Gln Tyr Cys 
            20  


<210>  7
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninised GA101 VK Kappa Light Chain variable domain FR1 
       framework sequence

<400>  7

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Glu 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys 
            20              


<210>  8
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninised GA101 VK Kappa Light Chain variable domain FR2 
       framework sequence

<400>  8

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  9
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninised GA101 VK Kappa Light Chain variable domain FR3 
       framework sequence

<400>  9

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninised GA101 VK Kappa Light Chain variable domain FR4 
       framework sequence

<400>  10

Phe Gly Ala Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  11
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninised GA101 VH Heavy Chain variable domain FR1 framework 
       sequence

<400>  11

Glu Val Gln Leu Val Gln Ser Gly Gly Glu Val Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Val Ser Cys Val Ala Ser Gly Phe 
            20                  25          


<210>  12
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninised GA101 VH Heavy Chain variable domain FR2 framework 
       sequence

<400>  12

Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Val Gly 
1               5                   10                  


<210>  13
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninised GA101 VH Heavy Chain variable domain FR3 framework 
       sequence

<400>  13

Arg Val Thr Ile Thr Arg Asp Asn Ser Lys Ser Thr Ala Tyr Leu Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninised GA101 VH Heavy Chain variable domain FR4 framework 
       sequence

<400>  14

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  15
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complete caninised GA101 VK kappa variable light chain sequence

<400>  15

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Glu 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Tyr Thr Phe Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  16
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complete caninised GA101 VH variable heavy chain sequence

<400>  16

Glu Val Gln Leu Val Gln Ser Gly Gly Glu Val Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Val Ser Cys Val Ala Ser Gly Phe Ala Phe Ser Tyr Ser 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Arg Asp Asn Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  17
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complete caninised GA101 heavy chain (HCB isotype)

<400>  17

Glu Val Gln Leu Val Gln Ser Gly Gly Glu Val Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Val Ser Cys Val Ala Ser Gly Tyr Ala Phe Ser Tyr Ser 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Arg Asp Asn Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu 
    130                 135                 140                 


Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser 
            180                 185                 190         


Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala 
        195                 200                 205             


Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg 
    210                 215                 220                 


Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp 
            260                 265                 270         


Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln 
        275                 280                 285             


Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys 
305                 310                 315                 320 


Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro 
                325                 330                 335     


Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser 
            340                 345                 350         


Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val 
    370                 375                 380                 


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr 
385                 390                 395                 400 


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys 
            420                 425                 430         


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu 
        435                 440                 445             


Ser His Ser Pro Gly Lys 
    450                 


<210>  18
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complete caninised GA-101 light chain

<400>  18

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Glu 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Tyr Thr Phe Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp 
        115                 120                 125             


Gln Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln 
145                 150                 155                 160 


Asp Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser 
            180                 185                 190         


His Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr 
        195                 200                 205             


Leu Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215                 220         


<210>  19
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  19

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Pro Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Thr Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Pro Arg Lys Phe Tyr Tyr Tyr Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  20
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  20

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Gly Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Leu His Val Pro Leu Thr Phe Gly Ala Gly Thr Arg Leu Glu Leu Lys 
            100                 105                 110         


<210>  21
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  21

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Pro Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Ile Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Trp Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Ile Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Ile 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Pro Arg Lys Phe Tyr Tyr Phe Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  22
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  22

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Val Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  23
<211>  469
<212>  PRT
<213>  Mus musculus

<400>  23

Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Pro 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Asn Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Thr Thr Asp Tyr Asn Ala 
65                  70                  75                  80  


Ala Phe Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Phe Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Pro Arg Lys Phe Tyr Tyr Tyr Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Ala 
    130                 135                 140                 


Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser 
145                 150                 155                 160 


Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr 
        195                 200                 205             


Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala 
    210                 215                 220                 


His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly 
225                 230                 235                 240 


Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val 
            260                 265                 270         


Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val 
    290                 295                 300                 


Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser 
305                 310                 315                 320 


Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met 
                325                 330                 335     


Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro 
        355                 360                 365             


Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln 
    370                 375                 380                 


Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr 
385                 390                 395                 400 


Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr 
                405                 410                 415     


Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu 
            420                 425                 430         


Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser 
        435                 440                 445             


Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser 
    450                 455                 460                 


Arg Thr Pro Gly Lys 
465                 


<210>  24
<211>  238
<212>  PRT
<213>  Mus musculus

<400>  24

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile 
        35                  40                  45              


Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Gly Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         


Phe Gln Gly Leu His Val Pro Leu Thr Phe Gly Ala Gly Thr Arg Leu 
        115                 120                 125             


Glu Leu Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 


Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235             


<210>  25
<211>  469
<212>  PRT
<213>  Mus musculus

<400>  25

Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Pro 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Ile Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Ser Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Trp Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Ser Ile Asp Tyr Asn Ala 
65                  70                  75                  80  


Ala Phe Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Ile Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Pro Arg Lys Phe Tyr Tyr Phe Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Ala 
    130                 135                 140                 


Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser 
145                 150                 155                 160 


Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr 
        195                 200                 205             


Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala 
    210                 215                 220                 


His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly 
225                 230                 235                 240 


Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val 
            260                 265                 270         


Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val 
    290                 295                 300                 


Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser 
305                 310                 315                 320 


Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met 
                325                 330                 335     


Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro 
        355                 360                 365             


Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln 
    370                 375                 380                 


Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr 
385                 390                 395                 400 


Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr 
                405                 410                 415     


Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu 
            420                 425                 430         


Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser 
        435                 440                 445             


Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser 
    450                 455                 460                 


Arg Thr Pro Gly Lys 
465                 


<210>  26
<211>  238
<212>  PRT
<213>  Mus musculus

<400>  26

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Asn Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile 
        35                  40                  45              


Val His Ser Asn Gly Asn Thr Tyr Val Glu Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         


Phe Gln Gly Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
        115                 120                 125             


Glu Leu Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 


Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235             


<210>  27
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric RA2 VH and canine HCA constant domain

<400>  27

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Pro 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Asn Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Thr Thr Asp Tyr Asn Ala 
65                  70                  75                  80  


Ala Phe Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Phe Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Pro Arg Lys Phe Tyr Tyr Tyr Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser 
145                 150                 155                 160 


Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ser Val Leu Gln Ser Ser Gly Leu His Ser Leu Ser Ser Met Val 
        195                 200                 205             


Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val 
    210                 215                 220                 


Val His Pro Ala Ser Asn Thr Lys Val Asp Lys Pro Val Phe Asn Glu 
225                 230                 235                 240 


Cys Arg Cys Thr Asp Thr Pro Pro Cys Pro Val Pro Glu Pro Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Leu Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg 
            260                 265                 270         


Ile Thr Arg Thr Pro Glu Val Thr Cys Val Val Leu Asp Leu Gly Arg 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val 
    290                 295                 300                 


His Thr Ala Lys Thr Gln Ser Arg Glu Gln Gln Phe Asn Gly Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly 
                325                 330                 335     


Lys Glu Phe Lys Cys Arg Val Asn His Ile Asp Leu Pro Ser Pro Ile 
            340                 345                 350         


Glu Arg Thr Ile Ser Lys Ala Arg Gly Arg Ala His Lys Pro Ser Val 
        355                 360                 365             


Tyr Val Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val 
    370                 375                 380                 


Ser Ile Thr Cys Leu Ile Lys Asp Phe Tyr Pro Pro Asp Ile Asp Val 
385                 390                 395                 400 


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Arg Lys His Arg Met 
                405                 410                 415     


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Ser Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Pro Phe Thr Cys 
        435                 440                 445             


Ala Val Met His Glu Thr Leu Gln Asn His Tyr Thr Asp Leu Ser Leu 
    450                 455                 460                 


Ser His Ser Pro Gly Lys 
465                 470 


<210>  28
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric RA2 VH and canine HCB constant domain

<400>  28

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Pro 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Asn Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Thr Thr Asp Tyr Asn Ala 
65                  70                  75                  80  


Ala Phe Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Phe Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Pro Arg Lys Phe Tyr Tyr Tyr Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser 
145                 150                 155                 160 


Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val 
        195                 200                 205             


Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg 
225                 230                 235                 240 


Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala 
                245                 250                 255     


Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val 
    290                 295                 300                 


Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln 
                325                 330                 335     


Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala 
            340                 345                 350         


Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala 
        355                 360                 365             


His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser 
    370                 375                 380                 


Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro 
385                 390                 395                 400 


Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser 
                405                 410                 415     


Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp 
        435                 440                 445             


Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
465                 470                 


<210>  29
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric RA2 VH and canine HCC constant domain

<400>  29

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Pro 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Asn Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Thr Thr Asp Tyr Asn Ala 
65                  70                  75                  80  


Ala Phe Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Phe Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Pro Arg Lys Phe Tyr Tyr Tyr Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Gln Ser Gly Ser 
145                 150                 155                 160 


Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Ile Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Val Ser Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val 
        195                 200                 205             


Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Pro Val Ala Lys Glu 
225                 230                 235                 240 


Cys Glu Cys Lys Cys Asn Cys Asn Asn Cys Pro Cys Pro Gly Cys Gly 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp Phe Val Asp Ser 
    290                 295                 300                 


Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu Glu Gln Ser Asn 
305                 310                 315                 320 


Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp 
                325                 330                 335     


Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn Lys Ala Leu Pro 
            340                 345                 350         


Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly Gln Ala His Gln 
        355                 360                 365             


Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu Met Ser Lys Asn 
    370                 375                 380                 


Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe Pro Pro Glu Ile 
385                 390                 395                 400 


Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr 
                405                 410                 415     


Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe 
        435                 440                 445             


Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Ile 
    450                 455                 460                 


Ser Leu Ser His Ser Pro Gly Lys 
465                 470         


<210>  30
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric RA2 VH and canine HCD constant domain

<400>  30

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Pro 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Asn Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Thr Thr Asp Tyr Asn Ala 
65                  70                  75                  80  


Ala Phe Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Phe Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Pro Arg Lys Phe Tyr Tyr Tyr Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser 
145                 150                 155                 160 


Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Thr Val 
        195                 200                 205             


Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val 
    210                 215                 220                 


Val His Pro Ala Ser Asn Thr Lys Val Asp Lys Pro Val Pro Lys Glu 
225                 230                 235                 240 


Ser Thr Cys Lys Cys Ile Ser Pro Cys Pro Val Pro Glu Ser Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg 
            260                 265                 270         


Ile Thr Arg Thr Pro Glu Ile Thr Cys Val Val Leu Asp Leu Gly Arg 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val 
    290                 295                 300                 


His Thr Ala Lys Thr Gln Pro Arg Glu Gln Gln Phe Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly 
                325                 330                 335     


Lys Glu Phe Lys Cys Arg Val Asn His Ile Gly Leu Pro Ser Pro Ile 
            340                 345                 350         


Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val 
        355                 360                 365             


Tyr Val Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val 
    370                 375                 380                 


Thr Leu Thr Cys Leu Ile Lys Asp Phe Tyr Pro Pro Glu Ile Asp Val 
385                 390                 395                 400 


Glu Trp Gln Ser Asn Gly Gln Pro Glu Pro Glu Ser Lys Tyr His Thr 
                405                 410                 415     


Thr Ala Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Ser Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Thr Phe Thr Cys 
        435                 440                 445             


Ala Val Met His Glu Ala Leu Gln Asn His Tyr Thr Asp Leu Ser Leu 
    450                 455                 460                 


Ser His Ser Pro Gly Lys 
465                 470 


<210>  31
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric RA2 VL and canine kLC constant domain

<400>  31

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Gly Asp Leu Gly Val Tyr Tyr 
            100                 105                 110         


Cys Phe Gln Gly Leu His Val Pro Leu Thr Phe Gly Ala Gly Thr Arg 
        115                 120                 125             


Leu Glu Leu Lys Arg Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln 
    130                 135                 140                 


Pro Ser Pro Asp Gln Leu His Thr Gly Ser Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Ser Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp 
                165                 170                 175     


Gly Val Ile Gln Asp Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr 
        195                 200                 205             


Glu Tyr Leu Ser His Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser 
    210                 215                 220                 


Leu Pro Ser Thr Leu Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg 
225                 230                 235                 240 


Val Asp 
        


<210>  32
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric RF2 VH and canine HCA constant domain

<400>  32

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Pro 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Ile Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Ser Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Trp Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Ser Ile Asp Tyr Asn Ala 
65                  70                  75                  80  


Ala Phe Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Ile Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Pro Arg Lys Phe Tyr Tyr Phe Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser 
145                 150                 155                 160 


Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ser Val Leu Gln Ser Ser Gly Leu His Ser Leu Ser Ser Met Val 
        195                 200                 205             


Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val 
    210                 215                 220                 


Val His Pro Ala Ser Asn Thr Lys Val Asp Lys Pro Val Phe Asn Glu 
225                 230                 235                 240 


Cys Arg Cys Thr Asp Thr Pro Pro Cys Pro Val Pro Glu Pro Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Leu Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg 
            260                 265                 270         


Ile Thr Arg Thr Pro Glu Val Thr Cys Val Val Leu Asp Leu Gly Arg 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val 
    290                 295                 300                 


His Thr Ala Lys Thr Gln Ser Arg Glu Gln Gln Phe Asn Gly Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly 
                325                 330                 335     


Lys Glu Phe Lys Cys Arg Val Asn His Ile Asp Leu Pro Ser Pro Ile 
            340                 345                 350         


Glu Arg Thr Ile Ser Lys Ala Arg Gly Arg Ala His Lys Pro Ser Val 
        355                 360                 365             


Tyr Val Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val 
    370                 375                 380                 


Ser Ile Thr Cys Leu Ile Lys Asp Phe Tyr Pro Pro Asp Ile Asp Val 
385                 390                 395                 400 


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Arg Lys His Arg Met 
                405                 410                 415     


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Ser Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Pro Phe Thr Cys 
        435                 440                 445             


Ala Val Met His Glu Thr Leu Gln Asn His Tyr Thr Asp Leu Ser Leu 
    450                 455                 460                 


Ser His Ser Pro Gly Lys 
465                 470 


<210>  33
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric RF2 VH and canine HCB constant domain

<400>  33

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Pro 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Ile Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Ser Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Trp Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Ser Ile Asp Tyr Asn Ala 
65                  70                  75                  80  


Ala Phe Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Ile Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Pro Arg Lys Phe Tyr Tyr Phe Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser 
145                 150                 155                 160 


Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val 
        195                 200                 205             


Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg 
225                 230                 235                 240 


Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala 
                245                 250                 255     


Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val 
    290                 295                 300                 


Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln 
                325                 330                 335     


Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala 
            340                 345                 350         


Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala 
        355                 360                 365             


His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser 
    370                 375                 380                 


Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro 
385                 390                 395                 400 


Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser 
                405                 410                 415     


Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp 
        435                 440                 445             


Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
465                 470                 


<210>  34
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric RF2 VH and canine HCC constant domain

<400>  34

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Pro 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Ile Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Ser Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Trp Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Ser Ile Asp Tyr Asn Ala 
65                  70                  75                  80  


Ala Phe Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Ile Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Pro Arg Lys Phe Tyr Tyr Phe Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Gln Ser Gly Ser 
145                 150                 155                 160 


Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Ile Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Val Ser Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val 
        195                 200                 205             


Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Pro Val Ala Lys Glu 
225                 230                 235                 240 


Cys Glu Cys Lys Cys Asn Cys Asn Asn Cys Pro Cys Pro Gly Cys Gly 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp Phe Val Asp Ser 
    290                 295                 300                 


Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu Glu Gln Ser Asn 
305                 310                 315                 320 


Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp 
                325                 330                 335     


Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn Lys Ala Leu Pro 
            340                 345                 350         


Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly Gln Ala His Gln 
        355                 360                 365             


Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu Met Ser Lys Asn 
    370                 375                 380                 


Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe Pro Pro Glu Ile 
385                 390                 395                 400 


Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr 
                405                 410                 415     


Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe 
        435                 440                 445             


Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Ile 
    450                 455                 460                 


Ser Leu Ser His Ser Pro Gly Lys 
465                 470         


<210>  35
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric RF2 VH and canine HCD constant domain

<400>  35

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Pro 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Ile Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Ser Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Trp Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Ser Ile Asp Tyr Asn Ala 
65                  70                  75                  80  


Ala Phe Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Ile Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Pro Arg Lys Phe Tyr Tyr Phe Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser 
145                 150                 155                 160 


Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Thr Val 
        195                 200                 205             


Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val 
    210                 215                 220                 


Val His Pro Ala Ser Asn Thr Lys Val Asp Lys Pro Val Pro Lys Glu 
225                 230                 235                 240 


Ser Thr Cys Lys Cys Ile Ser Pro Cys Pro Val Pro Glu Ser Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg 
            260                 265                 270         


Ile Thr Arg Thr Pro Glu Ile Thr Cys Val Val Leu Asp Leu Gly Arg 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val 
    290                 295                 300                 


His Thr Ala Lys Thr Gln Pro Arg Glu Gln Gln Phe Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly 
                325                 330                 335     


Lys Glu Phe Lys Cys Arg Val Asn His Ile Gly Leu Pro Ser Pro Ile 
            340                 345                 350         


Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val 
        355                 360                 365             


Tyr Val Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val 
    370                 375                 380                 


Thr Leu Thr Cys Leu Ile Lys Asp Phe Tyr Pro Pro Glu Ile Asp Val 
385                 390                 395                 400 


Glu Trp Gln Ser Asn Gly Gln Pro Glu Pro Glu Ser Lys Tyr His Thr 
                405                 410                 415     


Thr Ala Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Ser Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Thr Phe Thr Cys 
        435                 440                 445             


Ala Val Met His Glu Ala Leu Gln Asn His Tyr Thr Asp Leu Ser Leu 
    450                 455                 460                 


Ser His Ser Pro Gly Lys 
465                 470 


<210>  36
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric RF2 VL and canine kLC constant domain

<400>  36

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn 
        35                  40                  45              


Ile Val His Ser Asn Gly Asn Thr Tyr Val Glu Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr 
            100                 105                 110         


Cys Phe Gln Gly Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Leu Lys Arg Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln 
    130                 135                 140                 


Pro Ser Pro Asp Gln Leu His Thr Gly Ser Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Ser Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp 
                165                 170                 175     


Gly Val Ile Gln Asp Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr 
        195                 200                 205             


Glu Tyr Leu Ser His Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser 
    210                 215                 220                 


Leu Pro Ser Thr Leu Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg 
225                 230                 235                 240 


Val Asp 
        


<210>  37
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninised RA2 Heavy chain VH

<400>  37

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Thr Glu 
1               5                   10                  15      


Ser Leu Thr Ile Ser Cys Val Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Thr Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Thr Val Phe Leu 
65                  70                  75                  80  


Arg Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Pro Arg Lys Phe Tyr Tyr Tyr Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  38
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninised RA2 Light chain VL

<400>  38

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Gln Glu 
1               5                   10                  15      


Glu Glu Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Gly Asp Ala Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Leu His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  39
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complete caninised RA2 heavy chain HCA

<400>  39

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Thr Glu Ser Leu Thr Ile Ser Cys Val Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Asn Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Thr Thr Asp Tyr Asn Ala 
65                  70                  75                  80  


Ala Phe Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Thr 
                85                  90                  95      


Val Phe Leu Arg Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Ile Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Pro Arg Lys Phe Tyr Tyr Tyr Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser 
145                 150                 155                 160 


Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ser Val Leu Gln Ser Ser Gly Leu His Ser Leu Ser Ser Met Val 
        195                 200                 205             


Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val 
    210                 215                 220                 


Val His Pro Ala Ser Asn Thr Lys Val Asp Lys Pro Val Phe Asn Glu 
225                 230                 235                 240 


Cys Arg Cys Thr Asp Thr Pro Pro Cys Pro Val Pro Glu Pro Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Leu Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg 
            260                 265                 270         


Ile Thr Arg Thr Pro Glu Val Thr Cys Val Val Leu Asp Leu Gly Arg 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val 
    290                 295                 300                 


His Thr Ala Lys Thr Gln Ser Arg Glu Gln Gln Phe Asn Gly Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly 
                325                 330                 335     


Lys Glu Phe Lys Cys Arg Val Asn His Ile Asp Leu Pro Ser Pro Ile 
            340                 345                 350         


Glu Arg Thr Ile Ser Lys Ala Arg Gly Arg Ala His Lys Pro Ser Val 
        355                 360                 365             


Tyr Val Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val 
    370                 375                 380                 


Ser Ile Thr Cys Leu Ile Lys Asp Phe Tyr Pro Pro Asp Ile Asp Val 
385                 390                 395                 400 


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Arg Lys His Arg Met 
                405                 410                 415     


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Ser Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Pro Phe Thr Cys 
        435                 440                 445             


Ala Val Met His Glu Thr Leu Gln Asn His Tyr Thr Asp Leu Ser Leu 
    450                 455                 460                 


Ser His Ser Pro Gly Lys 
465                 470 


<210>  40
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complete caninised RA2 heavy chain HCB

<400>  40

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Thr Glu Ser Leu Thr Ile Ser Cys Val Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Asn Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Thr Thr Asp Tyr Asn Ala 
65                  70                  75                  80  


Ala Phe Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Thr 
                85                  90                  95      


Val Phe Leu Arg Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Ile Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Pro Arg Lys Phe Tyr Tyr Tyr Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser 
145                 150                 155                 160 


Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val 
        195                 200                 205             


Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg 
225                 230                 235                 240 


Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala 
                245                 250                 255     


Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val 
    290                 295                 300                 


Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln 
                325                 330                 335     


Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala 
            340                 345                 350         


Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala 
        355                 360                 365             


His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser 
    370                 375                 380                 


Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro 
385                 390                 395                 400 


Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser 
                405                 410                 415     


Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp 
        435                 440                 445             


Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
465                 470                 


<210>  41
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complete caninised RA2 heavy chain HCC

<400>  41

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Thr Glu Ser Leu Thr Ile Ser Cys Val Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Asn Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Thr Thr Asp Tyr Asn Ala 
65                  70                  75                  80  


Ala Phe Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Thr 
                85                  90                  95      


Val Phe Leu Arg Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Ile Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Pro Arg Lys Phe Tyr Tyr Tyr Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Gln Ser Gly Ser 
145                 150                 155                 160 


Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Ile Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Val Ser Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val 
        195                 200                 205             


Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Pro Val Ala Lys Glu 
225                 230                 235                 240 


Cys Glu Cys Lys Cys Asn Cys Asn Asn Cys Pro Cys Pro Gly Cys Gly 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp Phe Val Asp Ser 
    290                 295                 300                 


Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu Glu Gln Ser Asn 
305                 310                 315                 320 


Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp 
                325                 330                 335     


Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn Lys Ala Leu Pro 
            340                 345                 350         


Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly Gln Ala His Gln 
        355                 360                 365             


Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu Met Ser Lys Asn 
    370                 375                 380                 


Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe Pro Pro Glu Ile 
385                 390                 395                 400 


Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr 
                405                 410                 415     


Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe 
        435                 440                 445             


Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Ile 
    450                 455                 460                 


Ser Leu Ser His Ser Pro Gly Lys 
465                 470         


<210>  42
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complete caninised RA2 heavy chain HCD

<400>  42

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Thr Glu Ser Leu Thr Ile Ser Cys Val Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Asn Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Thr Thr Asp Tyr Asn Ala 
65                  70                  75                  80  


Ala Phe Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Thr 
                85                  90                  95      


Val Phe Leu Arg Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Ile Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Pro Arg Lys Phe Tyr Tyr Tyr Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser 
145                 150                 155                 160 


Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Thr Val 
        195                 200                 205             


Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val 
    210                 215                 220                 


Val His Pro Ala Ser Asn Thr Lys Val Asp Lys Pro Val Pro Lys Glu 
225                 230                 235                 240 


Ser Thr Cys Lys Cys Ile Ser Pro Cys Pro Val Pro Glu Ser Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg 
            260                 265                 270         


Ile Thr Arg Thr Pro Glu Ile Thr Cys Val Val Leu Asp Leu Gly Arg 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val 
    290                 295                 300                 


His Thr Ala Lys Thr Gln Pro Arg Glu Gln Gln Phe Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly 
                325                 330                 335     


Lys Glu Phe Lys Cys Arg Val Asn His Ile Gly Leu Pro Ser Pro Ile 
            340                 345                 350         


Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val 
        355                 360                 365             


Tyr Val Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val 
    370                 375                 380                 


Thr Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Glu Ile Asp Val 
385                 390                 395                 400 


Glu Trp Gln Ser Asn Gly Gln Pro Glu Pro Glu Ser Lys Tyr His Thr 
                405                 410                 415     


Thr Ala Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Ser Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Thr Phe Thr Cys 
        435                 440                 445             


Ala Val Met His Glu Ala Leu Gln Asn His Tyr Thr Asp Leu Ser Leu 
    450                 455                 460                 


Ser His Ser Pro Gly Lys 
465                 470 


<210>  43
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complete caninised RA2 light chain kLC

<400>  43

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser 
            20                  25                  30          


Val Ser Gln Glu Glu Glu Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Gly Asp Ala Gly Val Tyr Tyr 
            100                 105                 110         


Cys Phe Gln Gly Leu His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Leu Lys Arg Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln 
    130                 135                 140                 


Pro Ser Pro Asp Gln Leu His Thr Gly Ser Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Ser Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp 
                165                 170                 175     


Gly Val Ile Gln Asp Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr 
        195                 200                 205             


Glu Tyr Leu Ser His Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser 
    210                 215                 220                 


Leu Pro Ser Thr Leu Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg 
225                 230                 235                 240 


Val Asp 
        


<210>  44
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninised RF2 heavy chain VH

<400>  44

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Ala Glu 
1               5                   10                  15      


Ser Leu Thr Ile Ser Cys Val Ile Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Ile Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Thr Val Phe Ile 
65                  70                  75                  80  


Arg Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Pro Arg Lys Phe Tyr Tyr Phe Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  45
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninised RF2 light chain VL

<400>  45

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Gln Glu 
1               5                   10                  15      


Glu Glu Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Val Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Ala Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  46
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complete caninised RF2 heavy chain HCA

<400>  46

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Thr Glu Ser Leu Thr Ile Ser Cys Val Ile Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Ser Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Ser Ile Asp Tyr Asn Ala 
65                  70                  75                  80  


Ala Phe Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Thr 
                85                  90                  95      


Val Phe Ile Arg Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Ile Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Pro Arg Lys Phe Tyr Tyr Phe Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser 
145                 150                 155                 160 


Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ser Val Leu Gln Ser Ser Gly Leu His Ser Leu Ser Ser Met Val 
        195                 200                 205             


Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val 
    210                 215                 220                 


Val His Pro Ala Ser Asn Thr Lys Val Asp Lys Pro Val Phe Asn Glu 
225                 230                 235                 240 


Cys Arg Cys Thr Asp Thr Pro Pro Cys Pro Val Pro Glu Pro Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Leu Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg 
            260                 265                 270         


Ile Thr Arg Thr Pro Glu Val Thr Cys Val Val Leu Asp Leu Gly Arg 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val 
    290                 295                 300                 


His Thr Ala Lys Thr Gln Ser Arg Glu Gln Gln Phe Asn Gly Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly 
                325                 330                 335     


Lys Glu Phe Lys Cys Arg Val Asn His Ile Asp Leu Pro Ser Pro Ile 
            340                 345                 350         


Glu Arg Thr Ile Ser Lys Ala Arg Gly Arg Ala His Lys Pro Ser Val 
        355                 360                 365             


Tyr Val Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val 
    370                 375                 380                 


Ser Ile Thr Cys Leu Ile Lys Asp Phe Tyr Pro Pro Asp Ile Asp Val 
385                 390                 395                 400 


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Arg Lys His Arg Met 
                405                 410                 415     


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Ser Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Pro Phe Thr Cys 
        435                 440                 445             


Ala Val Met His Glu Thr Leu Gln Asn His Tyr Thr Asp Leu Ser Leu 
    450                 455                 460                 


Ser His Ser Pro Gly Lys 
465                 470 


<210>  47
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complete caninised RF2 heavy chain HCB

<400>  47

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Thr Glu Ser Leu Thr Ile Ser Cys Val Ile Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Ser Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Ser Ile Asp Tyr Asn Ala 
65                  70                  75                  80  


Ala Phe Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Thr 
                85                  90                  95      


Val Phe Ile Arg Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Ile Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Pro Arg Lys Phe Tyr Tyr Phe Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser 
145                 150                 155                 160 


Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val 
        195                 200                 205             


Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg 
225                 230                 235                 240 


Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala 
                245                 250                 255     


Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val 
    290                 295                 300                 


Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln 
                325                 330                 335     


Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala 
            340                 345                 350         


Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala 
        355                 360                 365             


His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser 
    370                 375                 380                 


Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro 
385                 390                 395                 400 


Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser 
                405                 410                 415     


Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp 
        435                 440                 445             


Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
465                 470                 


<210>  48
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complete caninised RF2 heavy chain HCC

<400>  48

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Thr Glu Ser Leu Thr Ile Ser Cys Val Ile Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Ser Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Ser Ile Asp Tyr Asn Ala 
65                  70                  75                  80  


Ala Phe Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Thr 
                85                  90                  95      


Val Phe Ile Arg Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Ile Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Pro Arg Lys Phe Tyr Tyr Phe Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Gln Ser Gly Ser 
145                 150                 155                 160 


Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Ile Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Val Ser Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val 
        195                 200                 205             


Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Pro Val Ala Lys Glu 
225                 230                 235                 240 


Cys Glu Cys Lys Cys Asn Cys Asn Asn Cys Pro Cys Pro Gly Cys Gly 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp Phe Val Asp Ser 
    290                 295                 300                 


Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu Glu Gln Ser Asn 
305                 310                 315                 320 


Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp 
                325                 330                 335     


Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn Lys Ala Leu Pro 
            340                 345                 350         


Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly Gln Ala His Gln 
        355                 360                 365             


Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu Met Ser Lys Asn 
    370                 375                 380                 


Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe Pro Pro Glu Ile 
385                 390                 395                 400 


Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr 
                405                 410                 415     


Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe 
        435                 440                 445             


Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Ile 
    450                 455                 460                 


Ser Leu Ser His Ser Pro Gly Lys 
465                 470         


<210>  49
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complete caninised RF2 heavy chain HCD

<400>  49

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Thr Glu Ser Leu Thr Ile Ser Cys Val Ile Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Ser Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Ser Ile Asp Tyr Asn Ala 
65                  70                  75                  80  


Ala Phe Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Thr 
                85                  90                  95      


Val Phe Ile Arg Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Ile Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Pro Arg Lys Phe Tyr Tyr Phe Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser 
145                 150                 155                 160 


Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Thr Val 
        195                 200                 205             


Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val 
    210                 215                 220                 


Val His Pro Ala Ser Asn Thr Lys Val Asp Lys Pro Val Pro Lys Glu 
225                 230                 235                 240 


Ser Thr Cys Lys Cys Ile Ser Pro Cys Pro Val Pro Glu Ser Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg 
            260                 265                 270         


Ile Thr Arg Thr Pro Glu Ile Thr Cys Val Val Leu Asp Leu Gly Arg 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val 
    290                 295                 300                 


His Thr Ala Lys Thr Gln Pro Arg Glu Gln Gln Phe Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly 
                325                 330                 335     


Lys Glu Phe Lys Cys Arg Val Asn His Ile Gly Leu Pro Ser Pro Ile 
            340                 345                 350         


Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val 
        355                 360                 365             


Tyr Val Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val 
    370                 375                 380                 


Thr Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Glu Ile Asp Val 
385                 390                 395                 400 


Glu Trp Gln Ser Asn Gly Gln Pro Glu Pro Glu Ser Lys Tyr His Thr 
                405                 410                 415     


Thr Ala Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Ser Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Thr Phe Thr Cys 
        435                 440                 445             


Ala Val Met His Glu Ala Leu Gln Asn His Tyr Thr Asp Leu Ser Leu 
    450                 455                 460                 


Ser His Ser Pro Gly Lys 
465                 470 


<210>  50
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complete caninised RF2 light chain kLC

<400>  50

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser 
            20                  25                  30          


Val Ser Gln Glu Glu Glu Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn 
        35                  40                  45              


Ile Val His Ser Asn Gly Asn Thr Tyr Val Glu Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Ala Gly Val Tyr Tyr 
            100                 105                 110         


Cys Phe Gln Gly Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Leu Lys Arg Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln 
    130                 135                 140                 


Pro Ser Pro Asp Gln Leu His Thr Gly Ser Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Ser Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp 
                165                 170                 175     


Gly Val Ile Gln Asp Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr 
        195                 200                 205             


Glu Tyr Leu Ser His Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser 
    210                 215                 220                 


Leu Pro Ser Thr Leu Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg 
225                 230                 235                 240 


Val Asp 
        


<210>  51
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinised  RA2 heavy chain VH

<400>  51

Gln Val Gln Leu Val Gln Ser Gly Gly Glu Leu Val Thr Pro Gly Glu 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Val Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Thr Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Pro Arg Lys Phe Tyr Tyr Tyr Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  52
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinised RA2 light chain VL

<400>  52

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Asp Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Asp Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Leu His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  53
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinised RF2 heavy chain VH

<400>  53

Gln Val Gln Leu Val Gln Ser Gly Gly Glu Leu Val Thr Pro Gly Glu 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Val Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Ile Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Pro Arg Lys Phe Tyr Tyr Phe Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  54
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinised RF2 light chain VL

<400>  54

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Asp Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Val Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RA2 CDRH1

<400>  55

Ser Leu Thr Asn Tyr Gly Val His 
1               5               


<210>  56
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RA2 CDRH2

<400>  56

Val Ile Trp Ser Gly Gly Thr Thr Asp Tyr Asn Ala Ala Phe Ile Ser 
1               5                   10                  15      


<210>  57
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RA2 CDRH3

<400>  57

Gly Pro Arg Lys Phe Tyr Tyr Tyr Gly Met Asp Tyr 
1               5                   10          


<210>  58
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RA2 CDRL1

<400>  58

Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RA2 CDRL2

<400>  59

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RA2 CDRL3

<400>  60

Phe Gln Gly Leu His Val Pro Leu Thr 
1               5                   


<210>  61
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RF2 CDRH1

<400>  61

Ser Leu Thr Ser Tyr Gly Val His 
1               5               


<210>  62
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RF2 CDRH2

<400>  62

Val Ile Trp Ser Gly Gly Ser Ile Asp Tyr Asn Ala Ala Phe Ile Ser 
1               5                   10                  15      


<210>  63
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RF2 CDRH3

<400>  63

Gly Pro Arg Lys Phe Tyr Tyr Phe Gly Met Asp Tyr 
1               5                   10          


<210>  64
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RF2 CDRL1

<400>  64

Arg Ser Ser Gln Asn Ile Val His Ser Asn Gly Asn Thr Tyr Val Glu 
1               5                   10                  15      


<210>  65
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RF2 CDRL2

<400>  65

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RF2 CDRL3

<400>  66

Phe Gln Gly Ser His Val Pro Leu Thr 
1               5                   


<210>  67
<211>  5
<212>  PRT
<213>  Canis familiaris

<400>  67

Ser Glu Lys Asn Ser 
1               5   


<210>  68
<211>  6
<212>  PRT
<213>  Canis familiaris

<400>  68

Ser Glu Lys Asn Ser Leu 
1               5       


<210>  69
<211>  6
<212>  PRT
<213>  Canis familiaris

<400>  69

Pro Ser Glu Lys Asn Ser 
1               5       


