                         SEQUENCE LISTING

<110>  Centre National de la Recherche Scientifique (CNRS)
       Universit Nice Sophia Antipolis
 
<120>  NOVEL ANTIBODIES ANTI-SPLA2-V AND USES THEREOF

<130>  CV - 128/PCT

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  138
<212>  PRT
<213>  human

<400>  1

Met Lys Gly Leu Leu Pro Leu Ala Trp Phe Leu Ala Cys Ser Val Pro 
1               5                   10                  15      


Ala Val Gln Gly Gly Leu Leu Asp Leu Lys Ser Met Ile Glu Lys Val 
            20                  25                  30          


Thr Gly Lys Asn Ala Leu Thr Asn Tyr Gly Phe Tyr Gly Cys Tyr Cys 
        35                  40                  45              


Gly Trp Gly Gly Arg Gly Thr Pro Lys Asp Gly Thr Asp Trp Cys Cys 
    50                  55                  60                  


Trp Ala His Asp His Cys Tyr Gly Arg Leu Glu Glu Lys Gly Cys Asn 
65                  70                  75                  80  


Ile Arg Thr Gln Ser Tyr Lys Tyr Arg Phe Ala Trp Gly Val Val Thr 
                85                  90                  95      


Cys Glu Pro Gly Pro Phe Cys His Val Asn Leu Cys Ala Cys Asp Arg 
            100                 105                 110         


Lys Leu Val Tyr Cys Leu Lys Arg Asn Leu Arg Ser Tyr Asn Pro Gln 
        115                 120                 125             


Tyr Gln Tyr Phe Pro Asn Ile Leu Cys Ser 
    130                 135             


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is Y, F, W, T, or S and preferably Y or F

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is T or N

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is F, L, V, I, A, or Y and preferably F or I

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is T or K

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is Y, F, W, T or S and preferably Y or S

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is V or Y

<400>  2

Gly Xaa Xaa Xaa Xaa Asp Xaa Xaa Ile 
1               5                   


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is Y or D

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is G, P or A, preferably A or G

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is S or N

<400>  3

Xaa Pro Xaa Xaa Gly 
1               5   


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is Y, W, F, T or S and preferably F or Y

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is W or D

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is F, L, V, I, A or Y and preferably F or V

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is P or V

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is Y or A

<400>  4

Xaa Cys Ala Arg Xaa Xaa Xaa Xaa Asp Tyr 
1               5                   10  


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1

<400>  5

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp 
1               5                   10      


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2

<400>  6

Thr Ser Asn Leu Ala Ser Gly 
1               5           


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is Y, W, F, T or S and preferably Y or W

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is H or S

<400>  7

Gln Xaa Xaa Ser Tyr Pro Leu Thr Phe 
1               5                   


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1

<400>  8

Gly Tyr Thr Phe Thr Asp Tyr 
1               5           


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1

<400>  9

Gly Phe Asn Ile Lys Asp Ser 
1               5           


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2

<400>  10

Tyr Pro Gly Ser Gly 
1               5   


<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2

<400>  11

Asp Pro Ala Asn Gly 
1               5   


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3

<400>  12

Phe Cys Ala Arg Trp Phe Pro Tyr 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3

<400>  13

Tyr Cys Ala Arg Asp Val Val Ala 
1               5               


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3

<400>  14

Gln Tyr His Ser Tyr Pro Leu Thr Phe 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3

<400>  15

Gln Trp Ser Ser Tyr Pro Leu Thr Phe 
1               5                   


<210>  16
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  16

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Val Ile Thr Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Gly Ser Gly Ser Thr Tyr Tyr Asp Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Met Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Phe Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  17
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  17

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105 


<210>  18
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  18

Glu Val Gln Leu Gln Leu Ser Gly Ala Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Ser 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Pro Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Val Ala Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  19
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  19

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105         


<210>  20
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  20
caggttcagc tgcagcagtc tggacctgag ctggtgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcact gactatgtta taacctgggt gaagcagaga      120

actggacagg gccttgagtg gattggagag atttatcctg gaagtggtag tacttactac      180

gatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccaa cacagcctac      240

atgcagctca gcagcatgac atctgaggac tctgcggtct atttctgtgc aagatggttc      300

ccctactttg actactgggg ccaaggcacc actctcacag tctcctca                   348


<210>  21
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  21
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atatcctgca gtgccagctc aagtgtaagt tacatgtact ggtaccagca gaagccagga      120

tcctccccca aaccctggat ttatcgcaca tccaacctgg cttctggagt ccctgctcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtat catagttacc cactcacgtt cggtgctggg      300

accaagctgg agctgaaacg g                                                321


<210>  22
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  22
gaggttcagc tacagctgtc tggggcagac cttgtgaagc caggggcctc agtcaagttg       60

tcctgcacag cttctggctt caacataaaa gactcctata ttcactgggt gaagcagagg      120

cctgaaccgg gcctggagtg gattggaagg attgatcctg cgaatggtaa tactaaatat      180

gacccgaagt tccagggcaa ggccactata acagcagaca cctcctccaa cacagcctac      240

ctgcagctca ccagcctgac atctgaggac actgccgtct attactgtgc tagggacgtg      300

gtggccttgg actactgggg ccaaggcacc actctcacag tctcctca                   348


<210>  23
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  23
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgccagctc aagtgtaagt tacatgtact ggtaccagca gaagccagga      120

tcctccccca gactcctgat ttatgacaca tccaacctgg cttctggagt ccctgttcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagccggat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtagttacc cactcacgtt cggtgctggg      300

accaagctgg agctgaaacg g                                                321


