                         SEQUENCE LISTING

<110>  Dudley, Samuel
 
<120>  METHODS FOR DIFFERENTIATING BETWEEN DIASTOLIC AND SYSTOLIC HEART 
       FAILURE

<130>  30303/47002 PCT

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  1274
<212>  PRT
<213>  Homo sapiens

<300>
<308>  NCBI / NP_000247.2
<309>  2012-06-02
<313>  (1)..(1274)

<400>  1

Met Pro Glu Pro Gly Lys Lys Pro Val Ser Ala Phe Ser Lys Lys Pro 
1               5                   10                  15      


Arg Ser Val Glu Val Ala Ala Gly Ser Pro Ala Val Phe Glu Ala Glu 
            20                  25                  30          


Thr Glu Arg Ala Gly Val Lys Val Arg Trp Gln Arg Gly Gly Ser Asp 
        35                  40                  45              


Ile Ser Ala Ser Asn Lys Tyr Gly Leu Ala Thr Glu Gly Thr Arg His 
    50                  55                  60                  


Thr Leu Thr Val Arg Glu Val Gly Pro Ala Asp Gln Gly Ser Tyr Ala 
65                  70                  75                  80  


Val Ile Ala Gly Ser Ser Lys Val Lys Phe Asp Leu Lys Val Ile Glu 
                85                  90                  95      


Ala Glu Lys Ala Glu Pro Met Leu Ala Pro Ala Pro Ala Pro Ala Glu 
            100                 105                 110         


Ala Thr Gly Ala Pro Gly Glu Ala Pro Ala Pro Ala Ala Glu Leu Gly 
        115                 120                 125             


Glu Ser Ala Pro Ser Pro Lys Gly Ser Ser Ser Ala Ala Leu Asn Gly 
    130                 135                 140                 


Pro Thr Pro Gly Ala Pro Asp Asp Pro Ile Gly Leu Phe Val Met Arg 
145                 150                 155                 160 


Pro Gln Asp Gly Glu Val Thr Val Gly Gly Ser Ile Thr Phe Ser Ala 
                165                 170                 175     


Arg Val Ala Gly Ala Ser Leu Leu Lys Pro Pro Val Val Lys Trp Phe 
            180                 185                 190         


Lys Gly Lys Trp Val Asp Leu Ser Ser Lys Val Gly Gln His Leu Gln 
        195                 200                 205             


Leu His Asp Ser Tyr Asp Arg Ala Ser Lys Val Tyr Leu Phe Glu Leu 
    210                 215                 220                 


His Ile Thr Asp Ala Gln Pro Ala Phe Thr Gly Ser Tyr Arg Cys Glu 
225                 230                 235                 240 


Val Ser Thr Lys Asp Lys Phe Asp Cys Ser Asn Phe Asn Leu Thr Val 
                245                 250                 255     


His Glu Ala Met Gly Thr Gly Asp Leu Asp Leu Leu Ser Ala Phe Arg 
            260                 265                 270         


Arg Thr Ser Leu Ala Gly Gly Gly Arg Arg Ile Ser Asp Ser His Glu 
        275                 280                 285             


Asp Thr Gly Ile Leu Asp Phe Ser Ser Leu Leu Lys Lys Arg Asp Ser 
    290                 295                 300                 


Phe Arg Thr Pro Arg Asp Ser Lys Leu Glu Ala Pro Ala Glu Glu Asp 
305                 310                 315                 320 


Val Trp Glu Ile Leu Arg Gln Ala Pro Pro Ser Glu Tyr Glu Arg Ile 
                325                 330                 335     


Ala Phe Gln Tyr Gly Val Thr Asp Leu Arg Gly Met Leu Lys Arg Leu 
            340                 345                 350         


Lys Gly Met Arg Arg Asp Glu Lys Lys Ser Thr Ala Phe Gln Lys Lys 
        355                 360                 365             


Leu Glu Pro Ala Tyr Gln Val Ser Lys Gly His Lys Ile Arg Leu Thr 
    370                 375                 380                 


Val Glu Leu Ala Asp His Asp Ala Glu Val Lys Trp Leu Lys Asn Gly 
385                 390                 395                 400 


Gln Glu Ile Gln Met Ser Gly Ser Lys Tyr Ile Phe Glu Ser Ile Gly 
                405                 410                 415     


Ala Lys Arg Thr Leu Thr Ile Ser Gln Cys Ser Leu Ala Asp Asp Ala 
            420                 425                 430         


Ala Tyr Gln Cys Val Val Gly Gly Glu Lys Cys Ser Thr Glu Leu Phe 
        435                 440                 445             


Val Lys Glu Pro Pro Val Leu Ile Thr Arg Pro Leu Glu Asp Gln Leu 
    450                 455                 460                 


Val Met Val Gly Gln Arg Val Glu Phe Glu Cys Glu Val Ser Glu Glu 
465                 470                 475                 480 


Gly Ala Gln Val Lys Trp Leu Lys Asp Gly Val Glu Leu Thr Arg Glu 
                485                 490                 495     


Glu Thr Phe Lys Tyr Arg Phe Lys Lys Asp Gly Gln Arg His His Leu 
            500                 505                 510         


Ile Ile Asn Glu Ala Met Leu Glu Asp Ala Gly His Tyr Ala Leu Cys 
        515                 520                 525             


Thr Ser Gly Gly Gln Ala Leu Ala Glu Leu Ile Val Gln Glu Lys Lys 
    530                 535                 540                 


Leu Glu Val Tyr Gln Ser Ile Ala Asp Leu Met Val Gly Ala Lys Asp 
545                 550                 555                 560 


Gln Ala Val Phe Lys Cys Glu Val Ser Asp Glu Asn Val Arg Gly Val 
                565                 570                 575     


Trp Leu Lys Asn Gly Lys Glu Leu Val Pro Asp Ser Arg Ile Lys Val 
            580                 585                 590         


Ser His Ile Gly Arg Val His Lys Leu Thr Ile Asp Asp Val Thr Pro 
        595                 600                 605             


Ala Asp Glu Ala Asp Tyr Ser Phe Val Pro Glu Gly Phe Ala Cys Asn 
    610                 615                 620                 


Leu Ser Ala Lys Leu His Phe Met Glu Val Lys Ile Asp Phe Val Pro 
625                 630                 635                 640 


Arg Gln Glu Pro Pro Lys Ile His Leu Asp Cys Pro Gly Arg Ile Pro 
                645                 650                 655     


Asp Thr Ile Val Val Val Ala Gly Asn Lys Leu Arg Leu Asp Val Pro 
            660                 665                 670         


Ile Ser Gly Asp Pro Ala Pro Thr Val Ile Trp Gln Lys Ala Ile Thr 
        675                 680                 685             


Gln Gly Asn Lys Ala Pro Ala Arg Pro Ala Pro Asp Ala Pro Glu Asp 
    690                 695                 700                 


Thr Gly Asp Ser Asp Glu Trp Val Phe Asp Lys Lys Leu Leu Cys Glu 
705                 710                 715                 720 


Thr Glu Gly Arg Val Arg Val Glu Thr Thr Lys Asp Arg Ser Ile Phe 
                725                 730                 735     


Thr Val Glu Gly Ala Glu Lys Glu Asp Glu Gly Val Tyr Thr Val Thr 
            740                 745                 750         


Val Lys Asn Pro Val Gly Glu Asp Gln Val Asn Leu Thr Val Lys Val 
        755                 760                 765             


Ile Asp Val Pro Asp Ala Pro Ala Ala Pro Lys Ile Ser Asn Val Gly 
    770                 775                 780                 


Glu Asp Ser Cys Thr Val Gln Trp Glu Pro Pro Ala Tyr Asp Gly Gly 
785                 790                 795                 800 


Gln Pro Ile Leu Gly Tyr Ile Leu Glu Arg Lys Lys Lys Lys Ser Tyr 
                805                 810                 815     


Arg Trp Met Arg Leu Asn Phe Asp Leu Ile Gln Glu Leu Ser His Glu 
            820                 825                 830         


Ala Arg Arg Met Ile Glu Gly Val Val Tyr Glu Met Arg Val Tyr Ala 
        835                 840                 845             


Val Asn Ala Ile Gly Met Ser Arg Pro Ser Pro Ala Ser Gln Pro Phe 
    850                 855                 860                 


Met Pro Ile Gly Pro Pro Ser Glu Pro Thr His Leu Ala Val Glu Asp 
865                 870                 875                 880 


Val Ser Asp Thr Thr Val Ser Leu Lys Trp Arg Pro Pro Glu Arg Val 
                885                 890                 895     


Gly Ala Gly Gly Leu Asp Gly Tyr Ser Val Glu Tyr Cys Pro Glu Gly 
            900                 905                 910         


Cys Ser Glu Trp Val Ala Ala Leu Gln Gly Leu Thr Glu His Thr Ser 
        915                 920                 925             


Ile Leu Val Lys Asp Leu Pro Thr Gly Ala Arg Leu Leu Phe Arg Val 
    930                 935                 940                 


Arg Ala His Asn Met Ala Gly Pro Gly Ala Pro Val Thr Thr Thr Glu 
945                 950                 955                 960 


Pro Val Thr Val Gln Glu Ile Leu Gln Arg Pro Arg Leu Gln Leu Pro 
                965                 970                 975     


Arg His Leu Arg Gln Thr Ile Gln Lys Lys Val Gly Glu Pro Val Asn 
            980                 985                 990         


Leu Leu Ile Pro Phe Gln Gly Lys  Pro Arg Pro Gln Val  Thr Trp Thr 
        995                 1000                 1005             


Lys Glu  Gly Gln Pro Leu Ala  Gly Glu Glu Val Ser  Ile Arg Asn 
    1010                 1015                 1020             


Ser Pro  Thr Asp Thr Ile Leu  Phe Ile Arg Ala Ala  Arg Arg Val 
    1025                 1030                 1035             


His Ser  Gly Thr Tyr Gln Val  Thr Val Arg Ile Glu  Asn Met Glu 
    1040                 1045                 1050             


Asp Lys  Ala Thr Leu Val Leu  Gln Val Val Asp Lys  Pro Ser Pro 
    1055                 1060                 1065             


Pro Gln  Asp Leu Arg Val Thr  Asp Ala Trp Gly Leu  Asn Val Ala 
    1070                 1075                 1080             


Leu Glu  Trp Lys Pro Pro Gln  Asp Val Gly Asn Thr  Glu Leu Trp 
    1085                 1090                 1095             


Gly Tyr  Thr Val Gln Lys Ala  Asp Lys Lys Thr Met  Glu Trp Phe 
    1100                 1105                 1110             


Thr Val  Leu Glu His Tyr Arg  Arg Thr His Cys Val  Val Pro Glu 
    1115                 1120                 1125             


Leu Ile  Ile Gly Asn Gly Tyr  Tyr Phe Arg Val Phe  Ser Gln Asn 
    1130                 1135                 1140             


Met Val  Gly Phe Ser Asp Arg  Ala Ala Thr Thr Lys  Glu Pro Val 
    1145                 1150                 1155             


Phe Ile  Pro Arg Pro Gly Ile  Thr Tyr Glu Pro Pro  Asn Tyr Lys 
    1160                 1165                 1170             


Ala Leu  Asp Phe Ser Glu Ala  Pro Ser Phe Thr Gln  Pro Leu Val 
    1175                 1180                 1185             


Asn Arg  Ser Val Ile Ala Gly  Tyr Thr Ala Met Leu  Cys Cys Ala 
    1190                 1195                 1200             


Val Arg  Gly Ser Pro Lys Pro  Lys Ile Ser Trp Phe  Lys Asn Gly 
    1205                 1210                 1215             


Leu Asp  Leu Gly Glu Asp Ala  Arg Phe Arg Met Phe  Ser Lys Gln 
    1220                 1225                 1230             


Gly Val  Leu Thr Leu Glu Ile  Arg Lys Pro Cys Pro  Phe Asp Gly 
    1235                 1240                 1245             


Gly Ile  Tyr Val Cys Arg Ala  Thr Asn Leu Gln Gly  Glu Ala Arg 
    1250                 1255                 1260             


Cys Glu  Cys Arg Leu Glu Val  Arg Val Pro Gln 
    1265                 1270                 


<210>  2
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  2

Ile His Leu Asp Cys Pro Gly Ser Thr Pro Asp Thr Ile Val Val Val 
1               5                   10                  15      


Ala Gly Asn Lys 
            20  


<210>  3
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  3

Val Glu Phe Glu Cys Glu Val Ser Glu Glu Gly Ala Gln Val Lys 
1               5                   10                  15  


<210>  4
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  4

Leu Thr Ile Asp Asp Val Thr Pro Ala Asp Glu Ala Asp Tyr Ser Phe 
1               5                   10                  15      


Val Pro Glu Gly Phe Ala Cys Asn Leu Ser Ala Lys 
            20                  25              


<210>  5
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  S-glutathionylated

<400>  5

Ile His Leu Asp Cys Pro Gly Ser Thr Pro Asp Thr Ile Val Val Val 
1               5                   10                  15      


Ala Gly Asn Lys 
            20  


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  S-glutathionylated

<400>  6

Val Glu Phe Glu Cys Glu Val Ser Glu Glu Gly Ala Gln Val Lys 
1               5                   10                  15  


<210>  7
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  S-glutathionylated

<400>  7

Leu Thr Ile Asp Asp Val Thr Pro Ala Asp Glu Ala Asp Tyr Ser Phe 
1               5                   10                  15      


Val Pro Glu Gly Phe Ala Cys Asn Leu Ser Ala Lys 
            20                  25              


<210>  8
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  DISULFID
<222>  (5)..(5)
<223>  Disulfide bonded to glutathione

<400>  8

Ile His Leu Asp Cys Pro Gly Ser Thr Pro Asp Thr Ile Val Val Val 
1               5                   10                  15      


Ala Gly Asn Lys 
            20  


<210>  9
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  DISULFID
<222>  (5)..(5)
<223>  Disulfide bonded to glutathione

<400>  9

Val Glu Phe Glu Cys Glu Val Ser Glu Glu Gly Ala Gln Val Lys 
1               5                   10                  15  


<210>  10
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  DISULFID
<222>  (23)..(23)
<223>  Disulfide bonded to glutathione

<400>  10

Leu Thr Ile Asp Asp Val Thr Pro Ala Asp Glu Ala Asp Tyr Ser Phe 
1               5                   10                  15      


Val Pro Glu Gly Phe Ala Cys Asn Leu Ser Ala Lys 
            20                  25              


<210>  11
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  11

Lys Ile His Leu Asp Cys Pro Gly Ser Thr Pro Asp Thr Ile Val Val 
1               5                   10                  15      


Val Ala Gly Asn Lys Leu 
            20          


<210>  12
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synethtic peptide

<400>  12

Lys Ile His Leu Asp Cys Pro Gly Ser Thr Pro Asp Thr Ile Val Val 
1               5                   10                  15      


Val Ala Gly Asn Lys Leu 
            20          


<210>  13
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  13

Lys Ile His Leu Asp Cys Pro Gly Ser Thr Pro Asp Thr Ile Val Val 
1               5                   10                  15      


Val Ala Gly Asn Lys Leu 
            20          


<210>  14
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  14

Lys Ile His Leu Asp Cys Pro Gly Ser Thr Pro Asp Thr Ile Val Val 
1               5                   10                  15      


Val Ala Gly Asn Lys Leu 
            20          


<210>  15
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  15

Lys Ile His Leu Asp Cys Pro Gly Ser Thr Pro Asp Thr Ile Val Val 
1               5                   10                  15      


Val Ala Gly Asn Lys Leu 
            20          


<210>  16
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  16

Arg Val Glu Phe Glu Cys Glu Val Ser Glu Glu Gly Ala Gln Val Lys 
1               5                   10                  15      


Trp 
    


<210>  17
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  17

Arg Val Glu Phe Glu Cys Glu Val Ser Glu Glu Gly Ala Gln Val Lys 
1               5                   10                  15      


Trp 
    


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  18

Arg Val Glu Phe Glu Cys Glu Val Ser Glu Glu Gly Ala Gln Val Lys 
1               5                   10                  15      


Trp 
    


<210>  19
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  19

Lys Leu Thr Ile Asp Asp Val Thr Pro Ala Asp Glu Ala Asp Tyr Ser 
1               5                   10                  15      


Phe Val Pro Glu Gly Phe Ala Cys Asn Leu Ser Ala Lys Leu 
            20                  25                  30  


<210>  20
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  20

Lys Leu Thr Ile Asp Asp Val Thr Pro Ala Asp Glu Ala Asp Tyr Ser 
1               5                   10                  15      


Phe Val Pro Glu Gly Phe Ala Cys Asn Leu Ser Ala Lys Leu 
            20                  25                  30  


<210>  21
<211>  1274
<212>  PRT
<213>  Homo sapiens

<300>
<308>  GenBank / CAA58882.1
<309>  1995-07-07
<313>  (1)..(1274)

<400>  21

Met Pro Glu Pro Gly Lys Lys Pro Val Ser Ala Phe Ser Lys Lys Pro 
1               5                   10                  15      


Arg Ser Val Glu Val Ala Ala Gly Ser Pro Ala Val Phe Glu Ala Glu 
            20                  25                  30          


Thr Glu Arg Ala Gly Val Lys Val Arg Trp Gln Arg Gly Gly Ser Asp 
        35                  40                  45              


Ile Ser Ala Ser Asn Lys Tyr Gly Leu Ala Thr Glu Gly Thr Arg His 
    50                  55                  60                  


Thr Leu Thr Val Arg Glu Val Gly Pro Ala Asp Gln Gly Ser Tyr Ala 
65                  70                  75                  80  


Val Ile Ala Gly Ser Ser Lys Val Lys Phe Asp Leu Lys Val Ile Glu 
                85                  90                  95      


Ala Glu Lys Ala Glu Pro Met Leu Ala Pro Ala Pro Ala Pro Ala Glu 
            100                 105                 110         


Ala Thr Gly Ala Pro Gly Glu Ala Pro Ala Pro Ala Ala Glu Leu Gly 
        115                 120                 125             


Glu Ser Ala Pro Ser Pro Lys Gly Ser Ser Ser Ala Ala Leu Asn Gly 
    130                 135                 140                 


Pro Thr Pro Gly Ala Pro Asp Asp Pro Ile Gly Leu Phe Val Met Arg 
145                 150                 155                 160 


Pro Gln Asp Gly Glu Val Thr Val Gly Gly Ser Ile Thr Phe Ser Ala 
                165                 170                 175     


Arg Val Ala Gly Ala Ser Leu Leu Lys Pro Pro Val Val Lys Trp Phe 
            180                 185                 190         


Lys Gly Lys Trp Val Asp Leu Ser Ser Lys Val Gly Gln His Leu Gln 
        195                 200                 205             


Leu His Asp Ser Tyr Asp Arg Ala Ser Lys Val Tyr Leu Phe Glu Leu 
    210                 215                 220                 


His Ile Thr Asp Ala Gln Pro Ala Phe Thr Gly Ser Tyr Arg Cys Glu 
225                 230                 235                 240 


Val Ser Thr Lys Asp Lys Phe Glu Cys Ser Asn Phe Asn Leu Thr Val 
                245                 250                 255     


His Glu Ala Met Gly Thr Gly Asp Leu Asp Leu Leu Ser Ala Phe Arg 
            260                 265                 270         


Arg Thr Ser Leu Ala Gly Gly Gly Arg Arg Ile Ser Asp Ser His Glu 
        275                 280                 285             


Asp Thr Gly Ile Leu Asp Phe Ser Ser Leu Leu Lys Lys Arg Asp Ser 
    290                 295                 300                 


Phe Arg Thr Pro Arg Asp Ser Lys Leu Glu Ala Pro Ala Glu Glu Asp 
305                 310                 315                 320 


Val Trp Glu Ile Leu Arg Gln Ala Pro Pro Ser Glu Tyr Glu Arg Ile 
                325                 330                 335     


Ala Phe Gln Tyr Gly Val Thr Asp Leu Arg Gly Met Leu Lys Arg Leu 
            340                 345                 350         


Lys Gly Met Arg Arg Asp Glu Lys Lys Ser Thr Ala Phe Gln Lys Lys 
        355                 360                 365             


Leu Glu Pro Ala Tyr Gln Val Ser Lys Gly His Lys Ile Arg Leu Thr 
    370                 375                 380                 


Val Glu Leu Ala Asp His Asp Ala Glu Val Lys Trp Leu Lys Asn Gly 
385                 390                 395                 400 


Gln Glu Ile Gln Met Ser Gly Ser Lys Tyr Ile Phe Glu Ser Ile Gly 
                405                 410                 415     


Ala Lys Arg Thr Leu Thr Ile Ser Gln Cys Ser Leu Ala Asp Asp Ala 
            420                 425                 430         


Ala Tyr Gln Cys Val Val Gly Gly Glu Lys Cys Ser Thr Glu Leu Phe 
        435                 440                 445             


Val Lys Glu Pro Pro Val Leu Ile Thr Arg Pro Leu Glu Asp Gln Leu 
    450                 455                 460                 


Val Met Val Gly Gln Arg Val Glu Phe Glu Cys Glu Val Ser Glu Glu 
465                 470                 475                 480 


Gly Ala Gln Val Lys Trp Leu Lys Asp Gly Val Glu Leu Thr Arg Glu 
                485                 490                 495     


Glu Thr Phe Lys Tyr Arg Phe Lys Lys Asp Gly Gln Arg His His Leu 
            500                 505                 510         


Ile Ile Asn Glu Ala Met Leu Glu Asp Ala Gly His Tyr Ala Leu Cys 
        515                 520                 525             


Thr Ser Gly Gly Gln Ala Leu Arg Glu Leu Ile Val Gln Glu Lys Lys 
    530                 535                 540                 


Leu Glu Val Tyr Gln Ser Ile Ala Asp Leu Met Val Gly Ala Lys Asp 
545                 550                 555                 560 


Gln Ala Val Phe Lys Cys Glu Val Ser Asp Glu Asn Val Arg Gly Val 
                565                 570                 575     


Trp Leu Lys Asn Gly Lys Glu Leu Val Pro Asp Ser Arg Ile Lys Val 
            580                 585                 590         


Ser His Ile Gly Arg Val His Lys Leu Thr Ile Asp Asp Val Thr Pro 
        595                 600                 605             


Ala Asp Glu Ala Asp Tyr Ser Phe Val Pro Glu Gly Phe Ala Cys Asn 
    610                 615                 620                 


Leu Ser Ala Lys Leu His Phe Met Glu Val Lys Ile Asp Phe Val Pro 
625                 630                 635                 640 


Arg Gln Glu Pro Pro Lys Ile His Leu Asp Cys Pro Gly Arg Ile Pro 
                645                 650                 655     


Asp Thr Ile Val Val Val Ala Gly Asn Lys Leu Arg Leu Asp Val Pro 
            660                 665                 670         


Ile Ser Gly Asp Pro Ala Pro Thr Val Ile Trp Gln Lys Ala Ile Thr 
        675                 680                 685             


Gln Gly Asn Lys Ala Pro Ala Arg Pro Ala Pro Asp Ala Pro Glu Asp 
    690                 695                 700                 


Thr Gly Asp Ser Asp Glu Trp Val Phe Asp Lys Lys Leu Leu Cys Glu 
705                 710                 715                 720 


Thr Glu Gly Arg Val Arg Val Glu Thr Thr Lys Asp Arg Ser Ile Phe 
                725                 730                 735     


Thr Val Glu Gly Ala Glu Lys Glu Asp Glu Gly Val Tyr Thr Val Thr 
            740                 745                 750         


Val Lys Asn Pro Val Gly Glu Asp Gln Val Asn Leu Thr Val Lys Val 
        755                 760                 765             


Ile Asp Val Pro Asp Ala Pro Ala Ala Pro Lys Ile Ser Asn Val Gly 
    770                 775                 780                 


Glu Asp Ser Cys Thr Val Gln Trp Glu Pro Pro Ala Tyr Asp Gly Gly 
785                 790                 795                 800 


Gln Pro Ile Leu Gly Tyr Ile Leu Glu Arg Lys Lys Lys Lys Ser Tyr 
                805                 810                 815     


Arg Trp Met Gln Leu Asn Phe Asp Leu Ile Gln Glu Leu Ser His Glu 
            820                 825                 830         


Ala Arg Arg Met Ile Glu Gly Val Val Tyr Glu Met Arg Val Tyr Ala 
        835                 840                 845             


Val Asn Ala Ile Gly Met Ser Arg Pro Ser Pro Ala Ser Gln Pro Phe 
    850                 855                 860                 


Met Pro Ile Gly Pro Pro Ser Glu Pro Thr His Leu Ala Val Glu Asp 
865                 870                 875                 880 


Val Ser Asp Thr Thr Val Ser Leu Lys Trp Arg Pro Pro Glu Arg Val 
                885                 890                 895     


Gly Ala Gly Gly Leu Asp Gly Tyr Ser Val Glu Tyr Cys Pro Glu Gly 
            900                 905                 910         


Cys Ser Glu Trp Val Ala Ala Leu Gln Gly Leu Thr Glu His Thr Ser 
        915                 920                 925             


Ile Leu Val Lys Asp Leu Pro Thr Gly Ala Arg Leu Leu Phe Arg Val 
    930                 935                 940                 


Arg Ala His Asn Met Ala Gly Pro Gly Ala Pro Val Thr Thr Thr Glu 
945                 950                 955                 960 


Pro Val Thr Val Gln Glu Ile Leu Gln Arg Pro Arg Leu Gln Leu Pro 
                965                 970                 975     


Arg His Leu Arg Gln Thr Ile Gln Lys Lys Val Gly Glu Pro Val Asn 
            980                 985                 990         


Leu Leu Ile Pro Phe Gln Gly Lys  Pro Arg Pro Gln Val  Thr Trp Thr 
        995                 1000                 1005             


Lys Glu  Gly Gln Pro Leu Ala  Gly Glu Glu Val Ser  Ile Arg Asn 
    1010                 1015                 1020             


Ser Pro  Thr Asp Thr Ile Leu  Phe Ile Arg Ala Ala  Arg Arg Val 
    1025                 1030                 1035             


His Ser  Gly Thr Tyr Gln Val  Thr Val Arg Ile Glu  Asn Met Glu 
    1040                 1045                 1050             


Asp Lys  Ala Thr Leu Val Leu  Gln Val Val Asp Lys  Pro Ser Pro 
    1055                 1060                 1065             


Pro Gln  Asp Leu Arg Val Thr  Asp Ala Trp Gly Leu  Asn Val Ala 
    1070                 1075                 1080             


Leu Glu  Trp Lys Pro Pro Gln  Asp Val Gly Asn Thr  Glu Leu Trp 
    1085                 1090                 1095             


Gly Tyr  Thr Val Gln Lys Ala  Asp Lys Lys Thr Met  Glu Trp Phe 
    1100                 1105                 1110             


Thr Val  Leu Glu His Tyr Arg  Arg Thr His Cys Val  Val Pro Glu 
    1115                 1120                 1125             


Leu Ile  Ile Gly Asn Gly Tyr  Tyr Phe Arg Val Phe  Ser Gln Asn 
    1130                 1135                 1140             


Met Val  Gly Phe Ser Asp Arg  Ala Ala Thr Thr Lys  Glu Pro Val 
    1145                 1150                 1155             


Phe Ile  Pro Arg Pro Gly Ile  Thr Tyr Glu Pro Pro  Asn Tyr Lys 
    1160                 1165                 1170             


Ala Leu  Asp Phe Ser Glu Ala  Pro Ser Phe Thr Gln  Pro Leu Val 
    1175                 1180                 1185             


Asn Arg  Ser Val Ile Ala Gly  Tyr Thr Ala Met Leu  Cys Cys Ala 
    1190                 1195                 1200             


Val Arg  Gly Ser Pro Lys Pro  Lys Ile Ser Trp Phe  Lys Asn Gly 
    1205                 1210                 1215             


Leu Asp  Leu Gly Glu Asp Ala  Arg Phe Arg Met Phe  Ser Lys Gln 
    1220                 1225                 1230             


Gly Val  Leu Thr Leu Glu Ile  Arg Lys Pro Cys Pro  Phe Asp Gly 
    1235                 1240                 1245             


Gly Ile  Tyr Val Cys Arg Ala  Thr Asn Leu Gln Gly  Glu Ala Arg 
    1250                 1255                 1260             


Cys Glu  Cys Arg Leu Glu Val  Arg Val Pro Gln 
    1265                 1270                 


