                         SEQUENCE LISTING

<110>  THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
       Kitajewski, Jan
       Shawber, Carrie
       Kangsamaksin, Thaned
 
<120>  HUMAN NOTCH1 DECOYS

<130>  0575/83119-A-PCT/JPW/GTK/BI

<150>  US 61/543,186
<151>  2011-10-04

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  2555
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Pro Leu Leu Ala Pro Leu Leu Cys Leu Ala Leu Leu Pro Ala 
1               5                   10                  15      


Leu Ala Ala Arg Gly Pro Arg Cys Ser Gln Pro Gly Glu Thr Cys Leu 
            20                  25                  30          


Asn Gly Gly Lys Cys Glu Ala Ala Asn Gly Thr Glu Ala Cys Val Cys 
        35                  40                  45              


Gly Gly Ala Phe Val Gly Pro Arg Cys Gln Asp Pro Asn Pro Cys Leu 
    50                  55                  60                  


Ser Thr Pro Cys Lys Asn Ala Gly Thr Cys His Val Val Asp Arg Arg 
65                  70                  75                  80  


Gly Val Ala Asp Tyr Ala Cys Ser Cys Ala Leu Gly Phe Ser Gly Pro 
                85                  90                  95      


Leu Cys Leu Thr Pro Leu Asp Asn Ala Cys Leu Thr Asn Pro Cys Arg 
            100                 105                 110         


Asn Gly Gly Thr Cys Asp Leu Leu Thr Leu Thr Glu Tyr Lys Cys Arg 
        115                 120                 125             


Cys Pro Pro Gly Trp Ser Gly Lys Ser Cys Gln Gln Ala Asp Pro Cys 
    130                 135                 140                 


Ala Ser Asn Pro Cys Ala Asn Gly Gly Gln Cys Leu Pro Phe Glu Ala 
145                 150                 155                 160 


Ser Tyr Ile Cys His Cys Pro Pro Ser Phe His Gly Pro Thr Cys Arg 
                165                 170                 175     


Gln Asp Val Asn Glu Cys Gly Gln Lys Pro Gly Leu Cys Arg His Gly 
            180                 185                 190         


Gly Thr Cys His Asn Glu Val Gly Ser Tyr Arg Cys Val Cys Arg Ala 
        195                 200                 205             


Thr His Thr Gly Pro Asn Cys Glu Arg Pro Tyr Val Pro Cys Ser Pro 
    210                 215                 220                 


Ser Pro Cys Gln Asn Gly Gly Thr Cys Arg Pro Thr Gly Asp Val Thr 
225                 230                 235                 240 


His Glu Cys Ala Cys Leu Pro Gly Phe Thr Gly Gln Asn Cys Glu Glu 
                245                 250                 255     


Asn Ile Asp Asp Cys Pro Gly Asn Asn Cys Lys Asn Gly Gly Ala Cys 
            260                 265                 270         


Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro Glu Trp Thr 
        275                 280                 285             


Gly Gln Tyr Cys Thr Glu Asp Val Asp Glu Cys Gln Leu Met Pro Asn 
    290                 295                 300                 


Ala Cys Gln Asn Gly Gly Thr Cys His Asn Thr His Gly Gly Tyr Asn 
305                 310                 315                 320 


Cys Val Cys Val Asn Gly Trp Thr Gly Glu Asp Cys Ser Glu Asn Ile 
                325                 330                 335     


Asp Asp Cys Ala Ser Ala Ala Cys Phe His Gly Ala Thr Cys His Asp 
            340                 345                 350         


Arg Val Ala Ser Phe Tyr Cys Glu Cys Pro His Gly Arg Thr Gly Leu 
        355                 360                 365             


Leu Cys His Leu Asn Asp Ala Cys Ile Ser Asn Pro Cys Asn Glu Gly 
    370                 375                 380                 


Ser Asn Cys Asp Thr Asn Pro Val Asn Gly Lys Ala Ile Cys Thr Cys 
385                 390                 395                 400 


Pro Ser Gly Tyr Thr Gly Pro Ala Cys Ser Gln Asp Val Asp Glu Cys 
                405                 410                 415     


Ser Leu Gly Ala Asn Pro Cys Glu His Ala Gly Lys Cys Ile Asn Thr 
            420                 425                 430         


Leu Gly Ser Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr Gly Pro Arg 
        435                 440                 445             


Cys Glu Ile Asp Val Asn Glu Cys Val Ser Asn Pro Cys Gln Asn Asp 
    450                 455                 460                 


Ala Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys Ile Cys Met Pro 
465                 470                 475                 480 


Gly Tyr Glu Gly Val His Cys Glu Val Asn Thr Asp Glu Cys Ala Ser 
                485                 490                 495     


Ser Pro Cys Leu His Asn Gly Arg Cys Leu Asp Lys Ile Asn Glu Phe 
            500                 505                 510         


Gln Cys Glu Cys Pro Thr Gly Phe Thr Gly His Leu Cys Gln Tyr Asp 
        515                 520                 525             


Val Asp Glu Cys Ala Ser Thr Pro Cys Lys Asn Gly Ala Lys Cys Leu 
    530                 535                 540                 


Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu Gly Tyr Thr Gly 
545                 550                 555                 560 


Thr His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro Asp Pro Cys His 
                565                 570                 575     


Tyr Gly Ser Cys Lys Asp Gly Val Ala Thr Phe Thr Cys Leu Cys Arg 
            580                 585                 590         


Pro Gly Tyr Thr Gly His His Cys Glu Thr Asn Ile Asn Glu Cys Ser 
        595                 600                 605             


Ser Gln Pro Cys Arg His Gly Gly Thr Cys Gln Asp Arg Asp Asn Ala 
    610                 615                 620                 


Tyr Leu Cys Phe Cys Leu Lys Gly Thr Thr Gly Pro Asn Cys Glu Ile 
625                 630                 635                 640 


Asn Leu Asp Asp Cys Ala Ser Ser Pro Cys Asp Ser Gly Thr Cys Leu 
                645                 650                 655     


Asp Lys Ile Asp Gly Tyr Glu Cys Ala Cys Glu Pro Gly Tyr Thr Gly 
            660                 665                 670         


Ser Met Cys Asn Ile Asn Ile Asp Glu Cys Ala Gly Asn Pro Cys His 
        675                 680                 685             


Asn Gly Gly Thr Cys Glu Asp Gly Ile Asn Gly Phe Thr Cys Arg Cys 
    690                 695                 700                 


Pro Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu Val Asn Glu Cys 
705                 710                 715                 720 


Asn Ser Asn Pro Cys Val His Gly Ala Cys Arg Asp Ser Leu Asn Gly 
                725                 730                 735     


Tyr Lys Cys Asp Cys Asp Pro Gly Trp Ser Gly Thr Asn Cys Asp Ile 
            740                 745                 750         


Asn Asn Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly Gly Thr Cys 
        755                 760                 765             


Lys Asp Met Thr Ser Gly Tyr Val Cys Thr Cys Arg Glu Gly Phe Ser 
    770                 775                 780                 


Gly Pro Asn Cys Gln Thr Asn Ile Asn Glu Cys Ala Ser Asn Pro Cys 
785                 790                 795                 800 


Leu Asn Gln Gly Thr Cys Ile Asp Asp Val Ala Gly Tyr Lys Cys Asn 
                805                 810                 815     


Cys Leu Leu Pro Tyr Thr Gly Ala Thr Cys Glu Val Val Leu Ala Pro 
            820                 825                 830         


Cys Ala Pro Ser Pro Cys Arg Asn Gly Gly Glu Cys Arg Gln Ser Glu 
        835                 840                 845             


Asp Tyr Glu Ser Phe Ser Cys Val Cys Pro Thr Gly Trp Gln Gly Gln 
    850                 855                 860                 


Thr Cys Glu Val Asp Ile Asn Glu Cys Val Leu Ser Pro Cys Arg His 
865                 870                 875                 880 


Gly Ala Ser Cys Gln Asn Thr His Gly Gly Tyr Arg Cys His Cys Gln 
                885                 890                 895     


Ala Gly Tyr Ser Gly Arg Asn Cys Glu Thr Asp Ile Asp Asp Cys Arg 
            900                 905                 910         


Pro Asn Pro Cys His Asn Gly Gly Ser Cys Thr Asp Gly Ile Asn Thr 
        915                 920                 925             


Ala Phe Cys Asp Cys Leu Pro Gly Phe Arg Gly Thr Phe Cys Glu Glu 
    930                 935                 940                 


Asp Ile Asn Glu Cys Ala Ser Asp Pro Cys Arg Asn Gly Ala Asn Cys 
945                 950                 955                 960 


Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro Ala Gly Phe Ser 
                965                 970                 975     


Gly Ile His Cys Glu Asn Asn Thr Pro Asp Cys Thr Glu Ser Ser Cys 
            980                 985                 990         


Phe Asn Gly Gly Thr Cys Val Asp  Gly Ile Asn Ser Phe  Thr Cys Leu 
        995                 1000                 1005             


Cys Pro  Pro Gly Phe Thr Gly  Ser Tyr Cys Gln His  Asp Val Asn 
    1010                 1015                 1020             


Glu Cys  Asp Ser Gln Pro Cys  Leu His Gly Gly Thr  Cys Gln Asp 
    1025                 1030                 1035             


Gly Cys  Gly Ser Tyr Arg Cys  Thr Cys Pro Gln Gly  Tyr Thr Gly 
    1040                 1045                 1050             


Pro Asn  Cys Gln Asn Leu Val  His Trp Cys Asp Ser  Ser Pro Cys 
    1055                 1060                 1065             


Lys Asn  Gly Gly Lys Cys Trp  Gln Thr His Thr Gln  Tyr Arg Cys 
    1070                 1075                 1080             


Glu Cys  Pro Ser Gly Trp Thr  Gly Leu Tyr Cys Asp  Val Pro Ser 
    1085                 1090                 1095             


Val Ser  Cys Glu Val Ala Ala  Gln Arg Gln Gly Val  Asp Val Ala 
    1100                 1105                 1110             


Arg Leu  Cys Gln His Gly Gly  Leu Cys Val Asp Ala  Gly Asn Thr 
    1115                 1120                 1125             


His His  Cys Arg Cys Gln Ala  Gly Tyr Thr Gly Ser  Tyr Cys Glu 
    1130                 1135                 1140             


Asp Leu  Val Asp Glu Cys Ser  Pro Ser Pro Cys Gln  Asn Gly Ala 
    1145                 1150                 1155             


Thr Cys  Thr Asp Tyr Leu Gly  Gly Tyr Ser Cys Lys  Cys Val Ala 
    1160                 1165                 1170             


Gly Tyr  His Gly Val Asn Cys  Ser Glu Glu Ile Asp  Glu Cys Leu 
    1175                 1180                 1185             


Ser His  Pro Cys Gln Asn Gly  Gly Thr Cys Leu Asp  Leu Pro Asn 
    1190                 1195                 1200             


Thr Tyr  Lys Cys Ser Cys Pro  Arg Gly Thr Gln Gly  Val His Cys 
    1205                 1210                 1215             


Glu Ile  Asn Val Asp Asp Cys  Asn Pro Pro Val Asp  Pro Val Ser 
    1220                 1225                 1230             


Arg Ser  Pro Lys Cys Phe Asn  Asn Gly Thr Cys Val  Asp Gln Val 
    1235                 1240                 1245             


Gly Gly  Tyr Ser Cys Thr Cys  Pro Pro Gly Phe Val  Gly Glu Arg 
    1250                 1255                 1260             


Cys Glu  Gly Asp Val Asn Glu  Cys Leu Ser Asn Pro  Cys Asp Ala 
    1265                 1270                 1275             


Arg Gly  Thr Gln Asn Cys Val  Gln Arg Val Asn Asp  Phe His Cys 
    1280                 1285                 1290             


Glu Cys  Arg Ala Gly His Thr  Gly Arg Arg Cys Glu  Ser Val Ile 
    1295                 1300                 1305             


Asn Gly  Cys Lys Gly Lys Pro  Cys Lys Asn Gly Gly  Thr Cys Ala 
    1310                 1315                 1320             


Val Ala  Ser Asn Thr Ala Arg  Gly Phe Ile Cys Lys  Cys Pro Ala 
    1325                 1330                 1335             


Gly Phe  Glu Gly Ala Thr Cys  Glu Asn Asp Ala Arg  Thr Cys Gly 
    1340                 1345                 1350             


Ser Leu  Arg Cys Leu Asn Gly  Gly Thr Cys Ile Ser  Gly Pro Arg 
    1355                 1360                 1365             


Ser Pro  Thr Cys Leu Cys Leu  Gly Pro Phe Thr Gly  Pro Glu Cys 
    1370                 1375                 1380             


Gln Phe  Pro Ala Ser Ser Pro  Cys Leu Gly Gly Asn  Pro Cys Tyr 
    1385                 1390                 1395             


Asn Gln  Gly Thr Cys Glu Pro  Thr Ser Glu Ser Pro  Phe Tyr Arg 
    1400                 1405                 1410             


Cys Leu  Cys Pro Ala Lys Phe  Asn Gly Leu Leu Cys  His Ile Leu 
    1415                 1420                 1425             


Asp Tyr  Ser Phe Gly Gly Gly  Ala Gly Arg Asp Ile  Pro Pro Pro 
    1430                 1435                 1440             


Leu Ile  Glu Glu Ala Cys Glu  Leu Pro Glu Cys Gln  Glu Asp Ala 
    1445                 1450                 1455             


Gly Asn  Lys Val Cys Ser Leu  Gln Cys Asn Asn His  Ala Cys Gly 
    1460                 1465                 1470             


Trp Asp  Gly Gly Asp Cys Ser  Leu Asn Phe Asn Asp  Pro Trp Lys 
    1475                 1480                 1485             


Asn Cys  Thr Gln Ser Leu Gln  Cys Trp Lys Tyr Phe  Ser Asp Gly 
    1490                 1495                 1500             


His Cys  Asp Ser Gln Cys Asn  Ser Ala Gly Cys Leu  Phe Asp Gly 
    1505                 1510                 1515             


Phe Asp  Cys Gln Arg Ala Glu  Gly Gln Cys Asn Pro  Leu Tyr Asp 
    1520                 1525                 1530             


Gln Tyr  Cys Lys Asp His Phe  Ser Asp Gly His Cys  Asp Gln Gly 
    1535                 1540                 1545             


Cys Asn  Ser Ala Glu Cys Glu  Trp Asp Gly Leu Asp  Cys Ala Glu 
    1550                 1555                 1560             


His Val  Pro Glu Arg Leu Ala  Ala Gly Thr Leu Val  Val Val Val 
    1565                 1570                 1575             


Leu Met  Pro Pro Glu Gln Leu  Arg Asn Ser Ser Phe  His Phe Leu 
    1580                 1585                 1590             


Arg Glu  Leu Ser Arg Val Leu  His Thr Asn Val Val  Phe Lys Arg 
    1595                 1600                 1605             


Asp Ala  His Gly Gln Gln Met  Ile Phe Pro Tyr Tyr  Gly Arg Glu 
    1610                 1615                 1620             


Glu Glu  Leu Arg Lys His Pro  Ile Lys Arg Ala Ala  Glu Gly Trp 
    1625                 1630                 1635             


Ala Ala  Pro Asp Ala Leu Leu  Gly Gln Val Lys Ala  Ser Leu Leu 
    1640                 1645                 1650             


Pro Gly  Gly Ser Glu Gly Gly  Arg Arg Arg Arg Glu  Leu Asp Pro 
    1655                 1660                 1665             


Met Asp  Val Arg Gly Ser Ile  Val Tyr Leu Glu Ile  Asp Asn Arg 
    1670                 1675                 1680             


Gln Cys  Val Gln Ala Ser Ser  Gln Cys Phe Gln Ser  Ala Thr Asp 
    1685                 1690                 1695             


Val Ala  Ala Phe Leu Gly Ala  Leu Ala Ser Leu Gly  Ser Leu Asn 
    1700                 1705                 1710             


Ile Pro  Tyr Lys Ile Glu Ala  Val Gln Ser Glu Thr  Val Glu Pro 
    1715                 1720                 1725             


Pro Pro  Pro Ala Gln Leu His  Phe Met Tyr Val Ala  Ala Ala Ala 
    1730                 1735                 1740             


Phe Val  Leu Leu Phe Phe Val  Gly Cys Gly Val Leu  Leu Ser Arg 
    1745                 1750                 1755             


Lys Arg  Arg Arg Gln His Gly  Gln Leu Trp Phe Pro  Glu Gly Phe 
    1760                 1765                 1770             


Lys Val  Ser Glu Ala Ser Lys  Lys Lys Arg Arg Glu  Pro Leu Gly 
    1775                 1780                 1785             


Glu Asp  Ser Val Gly Leu Lys  Pro Leu Lys Asn Ala  Ser Asp Gly 
    1790                 1795                 1800             


Ala Leu  Met Asp Asp Asn Gln  Asn Glu Trp Gly Asp  Glu Asp Leu 
    1805                 1810                 1815             


Glu Thr  Lys Lys Phe Arg Phe  Glu Glu Pro Val Val  Leu Pro Asp 
    1820                 1825                 1830             


Leu Asp  Asp Gln Thr Asp His  Arg Gln Trp Thr Gln  Gln His Leu 
    1835                 1840                 1845             


Asp Ala  Ala Asp Leu Arg Met  Ser Ala Met Ala Pro  Thr Pro Pro 
    1850                 1855                 1860             


Gln Gly  Glu Val Asp Ala Asp  Cys Met Asp Val Asn  Val Arg Gly 
    1865                 1870                 1875             


Pro Asp  Gly Phe Thr Pro Leu  Met Ile Ala Ser Cys  Ser Gly Gly 
    1880                 1885                 1890             


Gly Leu  Glu Thr Gly Asn Ser  Glu Glu Glu Glu Asp  Ala Pro Ala 
    1895                 1900                 1905             


Val Ile  Ser Asp Phe Ile Tyr  Gln Gly Ala Ser Leu  His Asn Gln 
    1910                 1915                 1920             


Thr Asp  Arg Thr Gly Glu Thr  Ala Leu His Leu Ala  Ala Arg Tyr 
    1925                 1930                 1935             


Ser Arg  Ser Asp Ala Ala Lys  Arg Leu Leu Glu Ala  Ser Ala Asp 
    1940                 1945                 1950             


Ala Asn  Ile Gln Asp Asn Met  Gly Arg Thr Pro Leu  His Ala Ala 
    1955                 1960                 1965             


Val Ser  Ala Asp Ala Gln Gly  Val Phe Gln Ile Leu  Ile Arg Asn 
    1970                 1975                 1980             


Arg Ala  Thr Asp Leu Asp Ala  Arg Met His Asp Gly  Thr Thr Pro 
    1985                 1990                 1995             


Leu Ile  Leu Ala Ala Arg Leu  Ala Val Glu Gly Met  Leu Glu Asp 
    2000                 2005                 2010             


Leu Ile  Asn Ser His Ala Asp  Val Asn Ala Val Asp  Asp Leu Gly 
    2015                 2020                 2025             


Lys Ser  Ala Leu His Trp Ala  Ala Ala Val Asn Asn  Val Asp Ala 
    2030                 2035                 2040             


Ala Val  Val Leu Leu Lys Asn  Gly Ala Asn Lys Asp  Met Gln Asn 
    2045                 2050                 2055             


Asn Arg  Glu Glu Thr Pro Leu  Phe Leu Ala Ala Arg  Glu Gly Ser 
    2060                 2065                 2070             


Tyr Glu  Thr Ala Lys Val Leu  Leu Asp His Phe Ala  Asn Arg Asp 
    2075                 2080                 2085             


Ile Thr  Asp His Met Asp Arg  Leu Pro Arg Asp Ile  Ala Gln Glu 
    2090                 2095                 2100             


Arg Met  His His Asp Ile Val  Arg Leu Leu Asp Glu  Tyr Asn Leu 
    2105                 2110                 2115             


Val Arg  Ser Pro Gln Leu His  Gly Ala Pro Leu Gly  Gly Thr Pro 
    2120                 2125                 2130             


Thr Leu  Ser Pro Pro Leu Cys  Ser Pro Asn Gly Tyr  Leu Gly Ser 
    2135                 2140                 2145             


Leu Lys  Pro Gly Val Gln Gly  Lys Lys Val Arg Lys  Pro Ser Ser 
    2150                 2155                 2160             


Lys Gly  Leu Ala Cys Gly Ser  Lys Glu Ala Lys Asp  Leu Lys Ala 
    2165                 2170                 2175             


Arg Arg  Lys Lys Ser Gln Asp  Gly Lys Gly Cys Leu  Leu Asp Ser 
    2180                 2185                 2190             


Ser Gly  Met Leu Ser Pro Val  Asp Ser Leu Glu Ser  Pro His Gly 
    2195                 2200                 2205             


Tyr Leu  Ser Asp Val Ala Ser  Pro Pro Leu Leu Pro  Ser Pro Phe 
    2210                 2215                 2220             


Gln Gln  Ser Pro Ser Val Pro  Leu Asn His Leu Pro  Gly Met Pro 
    2225                 2230                 2235             


Asp Thr  His Leu Gly Ile Gly  His Leu Asn Val Ala  Ala Lys Pro 
    2240                 2245                 2250             


Glu Met  Ala Ala Leu Gly Gly  Gly Gly Arg Leu Ala  Phe Glu Thr 
    2255                 2260                 2265             


Gly Pro  Pro Arg Leu Ser His  Leu Pro Val Ala Ser  Gly Thr Ser 
    2270                 2275                 2280             


Thr Val  Leu Gly Ser Ser Ser  Gly Gly Ala Leu Asn  Phe Thr Val 
    2285                 2290                 2295             


Gly Gly  Ser Thr Ser Leu Asn  Gly Gln Cys Glu Trp  Leu Ser Arg 
    2300                 2305                 2310             


Leu Gln  Ser Gly Met Val Pro  Asn Gln Tyr Asn Pro  Leu Arg Gly 
    2315                 2320                 2325             


Ser Val  Ala Pro Gly Pro Leu  Ser Thr Gln Ala Pro  Ser Leu Gln 
    2330                 2335                 2340             


His Gly  Met Val Gly Pro Leu  His Ser Ser Leu Ala  Ala Ser Ala 
    2345                 2350                 2355             


Leu Ser  Gln Met Met Ser Tyr  Gln Gly Leu Pro Ser  Thr Arg Leu 
    2360                 2365                 2370             


Ala Thr  Gln Pro His Leu Val  Gln Thr Gln Gln Val  Gln Pro Gln 
    2375                 2380                 2385             


Asn Leu  Gln Met Gln Gln Gln  Asn Leu Gln Pro Ala  Asn Ile Gln 
    2390                 2395                 2400             


Gln Gln  Gln Ser Leu Gln Pro  Pro Pro Pro Pro Pro  Gln Pro His 
    2405                 2410                 2415             


Leu Gly  Val Ser Ser Ala Ala  Ser Gly His Leu Gly  Arg Ser Phe 
    2420                 2425                 2430             


Leu Ser  Gly Glu Pro Ser Gln  Ala Asp Val Gln Pro  Leu Gly Pro 
    2435                 2440                 2445             


Ser Ser  Leu Ala Val His Thr  Ile Leu Pro Gln Glu  Ser Pro Ala 
    2450                 2455                 2460             


Leu Pro  Thr Ser Leu Pro Ser  Ser Leu Val Pro Pro  Val Thr Ala 
    2465                 2470                 2475             


Ala Gln  Phe Leu Thr Pro Pro  Ser Gln His Ser Tyr  Ser Ser Pro 
    2480                 2485                 2490             


Val Asp  Asn Thr Pro Ser His  Gln Leu Gln Val Pro  Glu His Pro 
    2495                 2500                 2505             


Phe Leu  Thr Pro Ser Pro Glu  Ser Pro Asp Gln Trp  Ser Ser Ser 
    2510                 2515                 2520             


Ser Pro  His Ser Asn Val Ser  Asp Trp Ser Glu Gly  Val Ser Ser 
    2525                 2530                 2535             


Pro Pro  Thr Ser Met Gln Ser  Gln Ile Ala Arg Ile  Pro Glu Ala 
    2540                 2545                 2550             


Phe Lys  
    2555 


<210>  2
<211>  2502
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Notch1 Decoy 10-24

<400>  2
atgccgccgc tcctggcgcc cctgctctgc ctggcgctgc tgcccgcgct cgccgcacga       60

ggcccgcgat gcatcagcaa cccctgtaac gagggctcca actgcgacac caaccctgtc      120

aatggcaagg ccatctgcac ctgcccctcg gggtacacgg gcccggcctg cagccaggac      180

gtggatgagt gctcgctggg tgccaacccc tgcgagcatg cgggcaagtg catcaacacg      240

ctgggctcct tcgagtgcca gtgtctgcag ggctacacgg gcccccgatg cgagatcgac      300

gtcaacgagt gcgtctcgaa cccgtgccag aacgacgcca cctgcctgga ccagattggg      360

gagttccagt gcatctgcat gcccggctac gagggtgtgc actgcgaggt caacacagac      420

gagtgtgcca gcagcccctg cctgcacaat ggccgctgcc tggacaagat caatgagttc      480

cagtgcgagt gccccacggg cttcactggg catctgtgcc agtacgatgt ggacgagtgt      540

gccagcaccc cctgcaagaa tggtgccaag tgcctggacg gacccaacac ttacacctgt      600

gtgtgcacgg aagggtacac ggggacgcac tgcgaggtgg acatcgatga gtgcgacccc      660

gacccctgcc actacggctc ctgcaaggac ggcgtcgcca ccttcacctg cctctgccgc      720

ccaggctaca cgggccacca ctgcgagacc aacatcaacg agtgctccag ccagccctgc      780

cgccacgggg gcacctgcca ggaccgcgac aacgcctacc tctgcttctg cctgaagggg      840

accacaggac ccaactgcga gatcaacctg gatgactgtg ccagcagccc ctgcgactcg      900

ggcacctgtc tggacaagat cgatggctac gagtgtgcct gtgagccggg ctacacaggg      960

agcatgtgta acatcaacat cgatgagtgt gcgggcaacc cctgccacaa cgggggcacc     1020

tgcgaggacg gcatcaatgg cttcacctgc cgctgccccg agggctacca cgaccccacc     1080

tgcctgtctg aggtcaatga gtgcaacagc aacccctgcg tccacggggc ctgccgggac     1140

agcctcaacg ggtacaagtg cgactgtgac cctgggtgga gtgggaccaa ctgtgacatc     1200

aacaacaatg agtgtgaatc caacccttgt gtcaacggcg gcacctgcaa agacatgacc     1260

agtggctacg tgtgcacctg ccgggagggc ttcagcggtc ccaactgcca gaccaacatc     1320

aacgagtgtg cgtccaaccc atgtctgaac cagggcacgt gtattgacga cgttgccggg     1380

tacaagtgca actgcctgct gccctacaca ggtgccacgt gtgaggtggt gctggccccg     1440

tgtgccccca gcccctgcag aaacggcggg gagtgcaggc aatccgagga ctatgagagc     1500

ttctcctgtg tctgccccac gggctggcaa gggcagacct gtgaggtcga catcaacgag     1560

tgcgttctga gcccgtgccg gcacggcgca tcctgccaga acacccacgg cggctaccgc     1620

tgccactgcc aggccggcta cagtgggcgc aactgcgaga ccgacatcga cgactgccgg     1680

cccaacccgt gtcacaacgg gggctcctgc acagacggca tcaacacggc cttctgcgac     1740

tgcctgcccg gcttccgggg cactttctgt gaggaggaca tcaacgagga tctgggcccg     1800

ggcgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc     1860

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc     1920

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag     1980

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag     2040

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg     2100

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa     2160

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     2220

cgggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     2280

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     2340

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     2400

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     2460

cactacacgc agaagagcct ctccctgtct ccgggtaaat ga                        2502


<210>  3
<211>  833
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Notch1 Decoy 10-24

<400>  3

Met Pro Pro Leu Leu Ala Pro Leu Leu Cys Leu Ala Leu Leu Pro Ala 
1               5                   10                  15      


Leu Ala Ala Arg Gly Pro Arg Cys Ile Ser Asn Pro Cys Asn Glu Gly 
            20                  25                  30          


Ser Asn Cys Asp Thr Asn Pro Val Asn Gly Lys Ala Ile Cys Thr Cys 
        35                  40                  45              


Pro Ser Gly Tyr Thr Gly Pro Ala Cys Ser Gln Asp Val Asp Glu Cys 
    50                  55                  60                  


Ser Leu Gly Ala Asn Pro Cys Glu His Ala Gly Lys Cys Ile Asn Thr 
65                  70                  75                  80  


Leu Gly Ser Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr Gly Pro Arg 
                85                  90                  95      


Cys Glu Ile Asp Val Asn Glu Cys Val Ser Asn Pro Cys Gln Asn Asp 
            100                 105                 110         


Ala Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys Ile Cys Met Pro 
        115                 120                 125             


Gly Tyr Glu Gly Val His Cys Glu Val Asn Thr Asp Glu Cys Ala Ser 
    130                 135                 140                 


Ser Pro Cys Leu His Asn Gly Arg Cys Leu Asp Lys Ile Asn Glu Phe 
145                 150                 155                 160 


Gln Cys Glu Cys Pro Thr Gly Phe Thr Gly His Leu Cys Gln Tyr Asp 
                165                 170                 175     


Val Asp Glu Cys Ala Ser Thr Pro Cys Lys Asn Gly Ala Lys Cys Leu 
            180                 185                 190         


Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu Gly Tyr Thr Gly 
        195                 200                 205             


Thr His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro Asp Pro Cys His 
    210                 215                 220                 


Tyr Gly Ser Cys Lys Asp Gly Val Ala Thr Phe Thr Cys Leu Cys Arg 
225                 230                 235                 240 


Pro Gly Tyr Thr Gly His His Cys Glu Thr Asn Ile Asn Glu Cys Ser 
                245                 250                 255     


Ser Gln Pro Cys Arg His Gly Gly Thr Cys Gln Asp Arg Asp Asn Ala 
            260                 265                 270         


Tyr Leu Cys Phe Cys Leu Lys Gly Thr Thr Gly Pro Asn Cys Glu Ile 
        275                 280                 285             


Asn Leu Asp Asp Cys Ala Ser Ser Pro Cys Asp Ser Gly Thr Cys Leu 
    290                 295                 300                 


Asp Lys Ile Asp Gly Tyr Glu Cys Ala Cys Glu Pro Gly Tyr Thr Gly 
305                 310                 315                 320 


Ser Met Cys Asn Ile Asn Ile Asp Glu Cys Ala Gly Asn Pro Cys His 
                325                 330                 335     


Asn Gly Gly Thr Cys Glu Asp Gly Ile Asn Gly Phe Thr Cys Arg Cys 
            340                 345                 350         


Pro Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu Val Asn Glu Cys 
        355                 360                 365             


Asn Ser Asn Pro Cys Val His Gly Ala Cys Arg Asp Ser Leu Asn Gly 
    370                 375                 380                 


Tyr Lys Cys Asp Cys Asp Pro Gly Trp Ser Gly Thr Asn Cys Asp Ile 
385                 390                 395                 400 


Asn Asn Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly Gly Thr Cys 
                405                 410                 415     


Lys Asp Met Thr Ser Gly Tyr Val Cys Thr Cys Arg Glu Gly Phe Ser 
            420                 425                 430         


Gly Pro Asn Cys Gln Thr Asn Ile Asn Glu Cys Ala Ser Asn Pro Cys 
        435                 440                 445             


Leu Asn Gln Gly Thr Cys Ile Asp Asp Val Ala Gly Tyr Lys Cys Asn 
    450                 455                 460                 


Cys Leu Leu Pro Tyr Thr Gly Ala Thr Cys Glu Val Val Leu Ala Pro 
465                 470                 475                 480 


Cys Ala Pro Ser Pro Cys Arg Asn Gly Gly Glu Cys Arg Gln Ser Glu 
                485                 490                 495     


Asp Tyr Glu Ser Phe Ser Cys Val Cys Pro Thr Gly Trp Gln Gly Gln 
            500                 505                 510         


Thr Cys Glu Val Asp Ile Asn Glu Cys Val Leu Ser Pro Cys Arg His 
        515                 520                 525             


Gly Ala Ser Cys Gln Asn Thr His Gly Gly Tyr Arg Cys His Cys Gln 
    530                 535                 540                 


Ala Gly Tyr Ser Gly Arg Asn Cys Glu Thr Asp Ile Asp Asp Cys Arg 
545                 550                 555                 560 


Pro Asn Pro Cys His Asn Gly Gly Ser Cys Thr Asp Gly Ile Asn Thr 
                565                 570                 575     


Ala Phe Cys Asp Cys Leu Pro Gly Phe Arg Gly Thr Phe Cys Glu Glu 
            580                 585                 590         


Asp Ile Asn Glu Asp Leu Gly Pro Gly Glu Pro Lys Ser Cys Asp Lys 
        595                 600                 605             


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
    610                 615                 620                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
625                 630                 635                 640 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                645                 650                 655     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            660                 665                 670         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        675                 680                 685             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    690                 695                 700                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
705                 710                 715                 720 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                725                 730                 735     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            740                 745                 750         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        755                 760                 765             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    770                 775                 780                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
785                 790                 795                 800 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                805                 810                 815     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            820                 825                 830         


Lys 
    


<210>  4
<211>  3957
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Notch1 Decoy 10-36

<400>  4
atgccgccgc tcctggcgcc cctgctctgc ctggcgctgc tgcccgcgct cgccgcacga       60

ggcccgcgat gcatcagcaa cccctgtaac gagggctcca actgcgacac caaccctgtc      120

aatggcaagg ccatctgcac ctgcccctcg gggtacacgg gcccggcctg cagccaggac      180

gtggatgagt gctcgctggg tgccaacccc tgcgagcatg cgggcaagtg catcaacacg      240

ctgggctcct tcgagtgcca gtgtctgcag ggctacacgg gcccccgatg cgagatcgac      300

gtcaacgagt gcgtctcgaa cccgtgccag aacgacgcca cctgcctgga ccagattggg      360

gagttccagt gcatctgcat gcccggctac gagggtgtgc actgcgaggt caacacagac      420

gagtgtgcca gcagcccctg cctgcacaat ggccgctgcc tggacaagat caatgagttc      480

cagtgcgagt gccccacggg cttcactggg catctgtgcc agtacgatgt ggacgagtgt      540

gccagcaccc cctgcaagaa tggtgccaag tgcctggacg gacccaacac ttacacctgt      600

gtgtgcacgg aagggtacac ggggacgcac tgcgaggtgg acatcgatga gtgcgacccc      660

gacccctgcc actacggctc ctgcaaggac ggcgtcgcca ccttcacctg cctctgccgc      720

ccaggctaca cgggccacca ctgcgagacc aacatcaacg agtgctccag ccagccctgc      780

cgccacgggg gcacctgcca ggaccgcgac aacgcctacc tctgcttctg cctgaagggg      840

accacaggac ccaactgcga gatcaacctg gatgactgtg ccagcagccc ctgcgactcg      900

ggcacctgtc tggacaagat cgatggctac gagtgtgcct gtgagccggg ctacacaggg      960

agcatgtgta acatcaacat cgatgagtgt gcgggcaacc cctgccacaa cgggggcacc     1020

tgcgaggacg gcatcaatgg cttcacctgc cgctgccccg agggctacca cgaccccacc     1080

tgcctgtctg aggtcaatga gtgcaacagc aacccctgcg tccacggggc ctgccgggac     1140

agcctcaacg ggtacaagtg cgactgtgac cctgggtgga gtgggaccaa ctgtgacatc     1200

aacaacaatg agtgtgaatc caacccttgt gtcaacggcg gcacctgcaa agacatgacc     1260

agtggctacg tgtgcacctg ccgggagggc ttcagcggtc ccaactgcca gaccaacatc     1320

aacgagtgtg cgtccaaccc atgtctgaac cagggcacgt gtattgacga cgttgccggg     1380

tacaagtgca actgcctgct gccctacaca ggtgccacgt gtgaggtggt gctggccccg     1440

tgtgccccca gcccctgcag aaacggcggg gagtgcaggc aatccgagga ctatgagagc     1500

ttctcctgtg tctgccccac gggctggcaa gggcagacct gtgaggtcga catcaacgag     1560

tgcgttctga gcccgtgccg gcacggcgca tcctgccaga acacccacgg cggctaccgc     1620

tgccactgcc aggccggcta cagtgggcgc aactgcgaga ccgacatcga cgactgccgg     1680

cccaacccgt gtcacaacgg gggctcctgc acagacggca tcaacacggc cttctgcgac     1740

tgcctgcccg gcttccgggg cactttctgt gaggaggaca tcaacgagtg tgccagtgac     1800

ccctgccgca acggggccaa ctgcacggac tgcgtggaca gctacacgtg cacctgcccc     1860

gcaggcttca gcgggatcca ctgtgagaac aacacgcctg actgcacaga gagctcctgc     1920

ttcaacggtg gcacctgcgt ggacggcatc aactcgttca cctgcctgtg tccacccggc     1980

ttcacgggca gctactgcca gcacgatgtc aatgagtgcg actcacagcc ctgcctgcat     2040

ggcggcacct gtcaggacgg ctgcggctcc tacaggtgca cctgccccca gggctacact     2100

ggccccaact gccagaacct tgtgcactgg tgtgactcct cgccctgcaa gaacggcggc     2160

aaatgctggc agacccacac ccagtaccgc tgcgagtgcc ccagcggctg gaccggcctt     2220

tactgcgacg tgcccagcgt gtcctgtgag gtggctgcgc agcgacaagg tgttgacgtt     2280

gcccgcctgt gccagcatgg agggctctgt gtggacgcgg gcaacacgca ccactgccgc     2340

tgccaggcgg gctacacagg cagctactgt gaggacctgg tggacgagtg ctcacccagc     2400

ccctgccaga acggggccac ctgcacggac tacctgggcg gctactcctg caagtgcgtg     2460

gccggctacc acggggtgaa ctgctctgag gagatcgacg agtgcctctc ccacccctgc     2520

cagaacgggg gcacctgcct cgacctcccc aacacctaca agtgctcctg cccacggggc     2580

actcagggtg tgcactgtga gatcaacgtg gacgactgca atccccccgt tgaccccgtg     2640

tcccggagcc ccaagtgctt taacaacggc acctgcgtgg accaggtggg cggctacagc     2700

tgcacctgcc cgccgggctt cgtgggtgag cgctgtgagg gggatgtcaa cgagtgcctg     2760

tccaatccct gcgacgcccg tggcacccag aactgcgtgc agcgcgtcaa tgacttccac     2820

tgcgagtgcc gtgctggtca caccgggcgc cgctgcgagt ccgtcatcaa tggctgcaaa     2880

ggcaagccct gcaagaatgg gggcacctgc gccgtggcct ccaacaccgc ccgcgggttc     2940

atctgcaagt gccctgcggg cttcgagggc gccacgtgtg agaatgacgc tcgtacctgc     3000

ggcagcctgc gctgcctcaa cggcggcaca tgcatctccg gcccgcgcag ccccacctgc     3060

ctgtgcctgg gccccttcac gggccccgaa tgccagttcc cggccagcag cccctgcctg     3120

ggcggcaacc cctgctacaa ccaggggacc tgtgagccca catccgagag ccccttctac     3180

cgttgcctgt gccccgccaa attcaacggg ctcttgtgcc acatcctgga ctacagcttc     3240

ggagatctgg gcccgggcga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc     3300

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac     3360

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa     3420

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca     3480

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     3540

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     3600

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     3660

accctgcccc catcccggga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc     3720

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     3780

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     3840

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     3900

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaatga        3957


<210>  5
<211>  1318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Notch1 Decoy 10-36

<400>  5

Met Pro Pro Leu Leu Ala Pro Leu Leu Cys Leu Ala Leu Leu Pro Ala 
1               5                   10                  15      


Leu Ala Ala Arg Gly Pro Arg Cys Ile Ser Asn Pro Cys Asn Glu Gly 
            20                  25                  30          


Ser Asn Cys Asp Thr Asn Pro Val Asn Gly Lys Ala Ile Cys Thr Cys 
        35                  40                  45              


Pro Ser Gly Tyr Thr Gly Pro Ala Cys Ser Gln Asp Val Asp Glu Cys 
    50                  55                  60                  


Ser Leu Gly Ala Asn Pro Cys Glu His Ala Gly Lys Cys Ile Asn Thr 
65                  70                  75                  80  


Leu Gly Ser Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr Gly Pro Arg 
                85                  90                  95      


Cys Glu Ile Asp Val Asn Glu Cys Val Ser Asn Pro Cys Gln Asn Asp 
            100                 105                 110         


Ala Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys Ile Cys Met Pro 
        115                 120                 125             


Gly Tyr Glu Gly Val His Cys Glu Val Asn Thr Asp Glu Cys Ala Ser 
    130                 135                 140                 


Ser Pro Cys Leu His Asn Gly Arg Cys Leu Asp Lys Ile Asn Glu Phe 
145                 150                 155                 160 


Gln Cys Glu Cys Pro Thr Gly Phe Thr Gly His Leu Cys Gln Tyr Asp 
                165                 170                 175     


Val Asp Glu Cys Ala Ser Thr Pro Cys Lys Asn Gly Ala Lys Cys Leu 
            180                 185                 190         


Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu Gly Tyr Thr Gly 
        195                 200                 205             


Thr His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro Asp Pro Cys His 
    210                 215                 220                 


Tyr Gly Ser Cys Lys Asp Gly Val Ala Thr Phe Thr Cys Leu Cys Arg 
225                 230                 235                 240 


Pro Gly Tyr Thr Gly His His Cys Glu Thr Asn Ile Asn Glu Cys Ser 
                245                 250                 255     


Ser Gln Pro Cys Arg His Gly Gly Thr Cys Gln Asp Arg Asp Asn Ala 
            260                 265                 270         


Tyr Leu Cys Phe Cys Leu Lys Gly Thr Thr Gly Pro Asn Cys Glu Ile 
        275                 280                 285             


Asn Leu Asp Asp Cys Ala Ser Ser Pro Cys Asp Ser Gly Thr Cys Leu 
    290                 295                 300                 


Asp Lys Ile Asp Gly Tyr Glu Cys Ala Cys Glu Pro Gly Tyr Thr Gly 
305                 310                 315                 320 


Ser Met Cys Asn Ile Asn Ile Asp Glu Cys Ala Gly Asn Pro Cys His 
                325                 330                 335     


Asn Gly Gly Thr Cys Glu Asp Gly Ile Asn Gly Phe Thr Cys Arg Cys 
            340                 345                 350         


Pro Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu Val Asn Glu Cys 
        355                 360                 365             


Asn Ser Asn Pro Cys Val His Gly Ala Cys Arg Asp Ser Leu Asn Gly 
    370                 375                 380                 


Tyr Lys Cys Asp Cys Asp Pro Gly Trp Ser Gly Thr Asn Cys Asp Ile 
385                 390                 395                 400 


Asn Asn Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly Gly Thr Cys 
                405                 410                 415     


Lys Asp Met Thr Ser Gly Tyr Val Cys Thr Cys Arg Glu Gly Phe Ser 
            420                 425                 430         


Gly Pro Asn Cys Gln Thr Asn Ile Asn Glu Cys Ala Ser Asn Pro Cys 
        435                 440                 445             


Leu Asn Gln Gly Thr Cys Ile Asp Asp Val Ala Gly Tyr Lys Cys Asn 
    450                 455                 460                 


Cys Leu Leu Pro Tyr Thr Gly Ala Thr Cys Glu Val Val Leu Ala Pro 
465                 470                 475                 480 


Cys Ala Pro Ser Pro Cys Arg Asn Gly Gly Glu Cys Arg Gln Ser Glu 
                485                 490                 495     


Asp Tyr Glu Ser Phe Ser Cys Val Cys Pro Thr Gly Trp Gln Gly Gln 
            500                 505                 510         


Thr Cys Glu Val Asp Ile Asn Glu Cys Val Leu Ser Pro Cys Arg His 
        515                 520                 525             


Gly Ala Ser Cys Gln Asn Thr His Gly Gly Tyr Arg Cys His Cys Gln 
    530                 535                 540                 


Ala Gly Tyr Ser Gly Arg Asn Cys Glu Thr Asp Ile Asp Asp Cys Arg 
545                 550                 555                 560 


Pro Asn Pro Cys His Asn Gly Gly Ser Cys Thr Asp Gly Ile Asn Thr 
                565                 570                 575     


Ala Phe Cys Asp Cys Leu Pro Gly Phe Arg Gly Thr Phe Cys Glu Glu 
            580                 585                 590         


Asp Ile Asn Glu Cys Ala Ser Asp Pro Cys Arg Asn Gly Ala Asn Cys 
        595                 600                 605             


Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro Ala Gly Phe Ser 
    610                 615                 620                 


Gly Ile His Cys Glu Asn Asn Thr Pro Asp Cys Thr Glu Ser Ser Cys 
625                 630                 635                 640 


Phe Asn Gly Gly Thr Cys Val Asp Gly Ile Asn Ser Phe Thr Cys Leu 
                645                 650                 655     


Cys Pro Pro Gly Phe Thr Gly Ser Tyr Cys Gln His Asp Val Asn Glu 
            660                 665                 670         


Cys Asp Ser Gln Pro Cys Leu His Gly Gly Thr Cys Gln Asp Gly Cys 
        675                 680                 685             


Gly Ser Tyr Arg Cys Thr Cys Pro Gln Gly Tyr Thr Gly Pro Asn Cys 
    690                 695                 700                 


Gln Asn Leu Val His Trp Cys Asp Ser Ser Pro Cys Lys Asn Gly Gly 
705                 710                 715                 720 


Lys Cys Trp Gln Thr His Thr Gln Tyr Arg Cys Glu Cys Pro Ser Gly 
                725                 730                 735     


Trp Thr Gly Leu Tyr Cys Asp Val Pro Ser Val Ser Cys Glu Val Ala 
            740                 745                 750         


Ala Gln Arg Gln Gly Val Asp Val Ala Arg Leu Cys Gln His Gly Gly 
        755                 760                 765             


Leu Cys Val Asp Ala Gly Asn Thr His His Cys Arg Cys Gln Ala Gly 
    770                 775                 780                 


Tyr Thr Gly Ser Tyr Cys Glu Asp Leu Val Asp Glu Cys Ser Pro Ser 
785                 790                 795                 800 


Pro Cys Gln Asn Gly Ala Thr Cys Thr Asp Tyr Leu Gly Gly Tyr Ser 
                805                 810                 815     


Cys Lys Cys Val Ala Gly Tyr His Gly Val Asn Cys Ser Glu Glu Ile 
            820                 825                 830         


Asp Glu Cys Leu Ser His Pro Cys Gln Asn Gly Gly Thr Cys Leu Asp 
        835                 840                 845             


Leu Pro Asn Thr Tyr Lys Cys Ser Cys Pro Arg Gly Thr Gln Gly Val 
    850                 855                 860                 


His Cys Glu Ile Asn Val Asp Asp Cys Asn Pro Pro Val Asp Pro Val 
865                 870                 875                 880 


Ser Arg Ser Pro Lys Cys Phe Asn Asn Gly Thr Cys Val Asp Gln Val 
                885                 890                 895     


Gly Gly Tyr Ser Cys Thr Cys Pro Pro Gly Phe Val Gly Glu Arg Cys 
            900                 905                 910         


Glu Gly Asp Val Asn Glu Cys Leu Ser Asn Pro Cys Asp Ala Arg Gly 
        915                 920                 925             


Thr Gln Asn Cys Val Gln Arg Val Asn Asp Phe His Cys Glu Cys Arg 
    930                 935                 940                 


Ala Gly His Thr Gly Arg Arg Cys Glu Ser Val Ile Asn Gly Cys Lys 
945                 950                 955                 960 


Gly Lys Pro Cys Lys Asn Gly Gly Thr Cys Ala Val Ala Ser Asn Thr 
                965                 970                 975     


Ala Arg Gly Phe Ile Cys Lys Cys Pro Ala Gly Phe Glu Gly Ala Thr 
            980                 985                 990         


Cys Glu Asn Asp Ala Arg Thr Cys  Gly Ser Leu Arg Cys  Leu Asn Gly 
        995                 1000                 1005             


Gly Thr  Cys Ile Ser Gly Pro  Arg Ser Pro Thr Cys  Leu Cys Leu 
    1010                 1015                 1020             


Gly Pro  Phe Thr Gly Pro Glu  Cys Gln Phe Pro Ala  Ser Ser Pro 
    1025                 1030                 1035             


Cys Leu  Gly Gly Asn Pro Cys  Tyr Asn Gln Gly Thr  Cys Glu Pro 
    1040                 1045                 1050             


Thr Ser  Glu Ser Pro Phe Tyr  Arg Cys Leu Cys Pro  Ala Lys Phe 
    1055                 1060                 1065             


Asn Gly  Leu Leu Cys His Ile  Leu Asp Tyr Ser Phe  Gly Asp Leu 
    1070                 1075                 1080             


Gly Pro  Gly Glu Pro Lys Ser  Cys Asp Lys Thr His  Thr Cys Pro 
    1085                 1090                 1095             


Pro Cys  Pro Ala Pro Glu Leu  Leu Gly Gly Pro Ser  Val Phe Leu 
    1100                 1105                 1110             


Phe Pro  Pro Lys Pro Lys Asp  Thr Leu Met Ile Ser  Arg Thr Pro 
    1115                 1120                 1125             


Glu Val  Thr Cys Val Val Val  Asp Val Ser His Glu  Asp Pro Glu 
    1130                 1135                 1140             


Val Lys  Phe Asn Trp Tyr Val  Asp Gly Val Glu Val  His Asn Ala 
    1145                 1150                 1155             


Lys Thr  Lys Pro Arg Glu Glu  Gln Tyr Asn Ser Thr  Tyr Arg Val 
    1160                 1165                 1170             


Val Ser  Val Leu Thr Val Leu  His Gln Asp Trp Leu  Asn Gly Lys 
    1175                 1180                 1185             


Glu Tyr  Lys Cys Lys Val Ser  Asn Lys Ala Leu Pro  Ala Pro Ile 
    1190                 1195                 1200             


Glu Lys  Thr Ile Ser Lys Ala  Lys Gly Gln Pro Arg  Glu Pro Gln 
    1205                 1210                 1215             


Val Tyr  Thr Leu Pro Pro Ser  Arg Glu Glu Met Thr  Lys Asn Gln 
    1220                 1225                 1230             


Val Ser  Leu Thr Cys Leu Val  Lys Gly Phe Tyr Pro  Ser Asp Ile 
    1235                 1240                 1245             


Ala Val  Glu Trp Glu Ser Asn  Gly Gln Pro Glu Asn  Asn Tyr Lys 
    1250                 1255                 1260             


Thr Thr  Pro Pro Val Leu Asp  Ser Asp Gly Ser Phe  Phe Leu Tyr 
    1265                 1270                 1275             


Ser Lys  Leu Thr Val Asp Lys  Ser Arg Trp Gln Gln  Gly Asn Val 
    1280                 1285                 1290             


Phe Ser  Cys Ser Val Met His  Glu Ala Leu His Asn  His Tyr Thr 
    1295                 1300                 1305             


Gln Lys  Ser Leu Ser Leu Ser  Pro Gly Lys 
    1310                 1315             


<210>  6
<211>  2034
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Notch1 Decoy 14-24

<400>  6
atgccgccgc tcctggcgcc cctgctctgc ctggcgctgc tgcccgcgct cgccgcacga       60

ggcccgcgat gtgccagcac cccctgcaag aatggtgcca agtgcctgga cggacccaac      120

acttacacct gtgtgtgcac ggaagggtac acggggacgc actgcgaggt ggacatcgat      180

gagtgcgacc ccgacccctg ccactacggc tcctgcaagg acggcgtcgc caccttcacc      240

tgcctctgcc gcccaggcta cacgggccac cactgcgaga ccaacatcaa cgagtgctcc      300

agccagccct gccgccacgg gggcacctgc caggaccgcg acaacgccta cctctgcttc      360

tgcctgaagg ggaccacagg acccaactgc gagatcaacc tggatgactg tgccagcagc      420

ccctgcgact cgggcacctg tctggacaag atcgatggct acgagtgtgc ctgtgagccg      480

ggctacacag ggagcatgtg taacatcaac atcgatgagt gtgcgggcaa cccctgccac      540

aacgggggca cctgcgagga cggcatcaat ggcttcacct gccgctgccc cgagggctac      600

cacgacccca cctgcctgtc tgaggtcaat gagtgcaaca gcaacccctg cgtccacggg      660

gcctgccggg acagcctcaa cgggtacaag tgcgactgtg accctgggtg gagtgggacc      720

aactgtgaca tcaacaacaa tgagtgtgaa tccaaccctt gtgtcaacgg cggcacctgc      780

aaagacatga ccagtggcta cgtgtgcacc tgccgggagg gcttcagcgg tcccaactgc      840

cagaccaaca tcaacgagtg tgcgtccaac ccatgtctga accagggcac gtgtattgac      900

gacgttgccg ggtacaagtg caactgcctg ctgccctaca caggtgccac gtgtgaggtg      960

gtgctggccc cgtgtgcccc cagcccctgc agaaacggcg gggagtgcag gcaatccgag     1020

gactatgaga gcttctcctg tgtctgcccc acgggctggc aagggcagac ctgtgaggtc     1080

gacatcaacg agtgcgttct gagcccgtgc cggcacggcg catcctgcca gaacacccac     1140

ggcggctacc gctgccactg ccaggccggc tacagtgggc gcaactgcga gaccgacatc     1200

gacgactgcc ggcccaaccc gtgtcacaac gggggctcct gcacagacgg catcaacacg     1260

gccttctgcg actgcctgcc cggcttccgg ggcactttct gtgaggagga catcaacgag     1320

gatctgggcc cgggcgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca     1380

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc     1440

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac     1500

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag     1560

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1620

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1680

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1740

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1800

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1860

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1920

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1980

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa atga           2034


<210>  7
<211>  677
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Notch1 Decoy 14-24

<400>  7

Met Pro Pro Leu Leu Ala Pro Leu Leu Cys Leu Ala Leu Leu Pro Ala 
1               5                   10                  15      


Leu Ala Ala Arg Gly Pro Arg Cys Ala Ser Thr Pro Cys Lys Asn Gly 
            20                  25                  30          


Ala Lys Cys Leu Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu 
        35                  40                  45              


Gly Tyr Thr Gly Thr His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro 
    50                  55                  60                  


Asp Pro Cys His Tyr Gly Ser Cys Lys Asp Gly Val Ala Thr Phe Thr 
65                  70                  75                  80  


Cys Leu Cys Arg Pro Gly Tyr Thr Gly His His Cys Glu Thr Asn Ile 
                85                  90                  95      


Asn Glu Cys Ser Ser Gln Pro Cys Arg His Gly Gly Thr Cys Gln Asp 
            100                 105                 110         


Arg Asp Asn Ala Tyr Leu Cys Phe Cys Leu Lys Gly Thr Thr Gly Pro 
        115                 120                 125             


Asn Cys Glu Ile Asn Leu Asp Asp Cys Ala Ser Ser Pro Cys Asp Ser 
    130                 135                 140                 


Gly Thr Cys Leu Asp Lys Ile Asp Gly Tyr Glu Cys Ala Cys Glu Pro 
145                 150                 155                 160 


Gly Tyr Thr Gly Ser Met Cys Asn Ile Asn Ile Asp Glu Cys Ala Gly 
                165                 170                 175     


Asn Pro Cys His Asn Gly Gly Thr Cys Glu Asp Gly Ile Asn Gly Phe 
            180                 185                 190         


Thr Cys Arg Cys Pro Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu 
        195                 200                 205             


Val Asn Glu Cys Asn Ser Asn Pro Cys Val His Gly Ala Cys Arg Asp 
    210                 215                 220                 


Ser Leu Asn Gly Tyr Lys Cys Asp Cys Asp Pro Gly Trp Ser Gly Thr 
225                 230                 235                 240 


Asn Cys Asp Ile Asn Asn Asn Glu Cys Glu Ser Asn Pro Cys Val Asn 
                245                 250                 255     


Gly Gly Thr Cys Lys Asp Met Thr Ser Gly Tyr Val Cys Thr Cys Arg 
            260                 265                 270         


Glu Gly Phe Ser Gly Pro Asn Cys Gln Thr Asn Ile Asn Glu Cys Ala 
        275                 280                 285             


Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Ile Asp Asp Val Ala Gly 
    290                 295                 300                 


Tyr Lys Cys Asn Cys Leu Leu Pro Tyr Thr Gly Ala Thr Cys Glu Val 
305                 310                 315                 320 


Val Leu Ala Pro Cys Ala Pro Ser Pro Cys Arg Asn Gly Gly Glu Cys 
                325                 330                 335     


Arg Gln Ser Glu Asp Tyr Glu Ser Phe Ser Cys Val Cys Pro Thr Gly 
            340                 345                 350         


Trp Gln Gly Gln Thr Cys Glu Val Asp Ile Asn Glu Cys Val Leu Ser 
        355                 360                 365             


Pro Cys Arg His Gly Ala Ser Cys Gln Asn Thr His Gly Gly Tyr Arg 
    370                 375                 380                 


Cys His Cys Gln Ala Gly Tyr Ser Gly Arg Asn Cys Glu Thr Asp Ile 
385                 390                 395                 400 


Asp Asp Cys Arg Pro Asn Pro Cys His Asn Gly Gly Ser Cys Thr Asp 
                405                 410                 415     


Gly Ile Asn Thr Ala Phe Cys Asp Cys Leu Pro Gly Phe Arg Gly Thr 
            420                 425                 430         


Phe Cys Glu Glu Asp Ile Asn Glu Asp Leu Gly Pro Gly Glu Pro Lys 
        435                 440                 445             


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
    450                 455                 460                 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
465                 470                 475                 480 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                485                 490                 495     


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            500                 505                 510         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        515                 520                 525             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    530                 535                 540                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
545                 550                 555                 560 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                565                 570                 575     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
            580                 585                 590         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        595                 600                 605             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    610                 615                 620                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
625                 630                 635                 640 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                645                 650                 655     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            660                 665                 670         


Leu Ser Pro Gly Lys 
        675         


<210>  8
<211>  3489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Notch1 Decoy 14-36

<400>  8
atgccgccgc tcctggcgcc cctgctctgc ctggcgctgc tgcccgcgct cgccgcacga       60

ggcccgcgat gtgccagcac cccctgcaag aatggtgcca agtgcctgga cggacccaac      120

acttacacct gtgtgtgcac ggaagggtac acggggacgc actgcgaggt ggacatcgat      180

gagtgcgacc ccgacccctg ccactacggc tcctgcaagg acggcgtcgc caccttcacc      240

tgcctctgcc gcccaggcta cacgggccac cactgcgaga ccaacatcaa cgagtgctcc      300

agccagccct gccgccacgg gggcacctgc caggaccgcg acaacgccta cctctgcttc      360

tgcctgaagg ggaccacagg acccaactgc gagatcaacc tggatgactg tgccagcagc      420

ccctgcgact cgggcacctg tctggacaag atcgatggct acgagtgtgc ctgtgagccg      480

ggctacacag ggagcatgtg taacatcaac atcgatgagt gtgcgggcaa cccctgccac      540

aacgggggca cctgcgagga cggcatcaat ggcttcacct gccgctgccc cgagggctac      600

cacgacccca cctgcctgtc tgaggtcaat gagtgcaaca gcaacccctg cgtccacggg      660

gcctgccggg acagcctcaa cgggtacaag tgcgactgtg accctgggtg gagtgggacc      720

aactgtgaca tcaacaacaa tgagtgtgaa tccaaccctt gtgtcaacgg cggcacctgc      780

aaagacatga ccagtggcta cgtgtgcacc tgccgggagg gcttcagcgg tcccaactgc      840

cagaccaaca tcaacgagtg tgcgtccaac ccatgtctga accagggcac gtgtattgac      900

gacgttgccg ggtacaagtg caactgcctg ctgccctaca caggtgccac gtgtgaggtg      960

gtgctggccc cgtgtgcccc cagcccctgc agaaacggcg gggagtgcag gcaatccgag     1020

gactatgaga gcttctcctg tgtctgcccc acgggctggc aagggcagac ctgtgaggtc     1080

gacatcaacg agtgcgttct gagcccgtgc cggcacggcg catcctgcca gaacacccac     1140

ggcggctacc gctgccactg ccaggccggc tacagtgggc gcaactgcga gaccgacatc     1200

gacgactgcc ggcccaaccc gtgtcacaac gggggctcct gcacagacgg catcaacacg     1260

gccttctgcg actgcctgcc cggcttccgg ggcactttct gtgaggagga catcaacgag     1320

tgtgccagtg acccctgccg caacggggcc aactgcacgg actgcgtgga cagctacacg     1380

tgcacctgcc ccgcaggctt cagcgggatc cactgtgaga acaacacgcc tgactgcaca     1440

gagagctcct gcttcaacgg tggcacctgc gtggacggca tcaactcgtt cacctgcctg     1500

tgtccacccg gcttcacggg cagctactgc cagcacgatg tcaatgagtg cgactcacag     1560

ccctgcctgc atggcggcac ctgtcaggac ggctgcggct cctacaggtg cacctgcccc     1620

cagggctaca ctggccccaa ctgccagaac cttgtgcact ggtgtgactc ctcgccctgc     1680

aagaacggcg gcaaatgctg gcagacccac acccagtacc gctgcgagtg ccccagcggc     1740

tggaccggcc tttactgcga cgtgcccagc gtgtcctgtg aggtggctgc gcagcgacaa     1800

ggtgttgacg ttgcccgcct gtgccagcat ggagggctct gtgtggacgc gggcaacacg     1860

caccactgcc gctgccaggc gggctacaca ggcagctact gtgaggacct ggtggacgag     1920

tgctcaccca gcccctgcca gaacggggcc acctgcacgg actacctggg cggctactcc     1980

tgcaagtgcg tggccggcta ccacggggtg aactgctctg aggagatcga cgagtgcctc     2040

tcccacccct gccagaacgg gggcacctgc ctcgacctcc ccaacaccta caagtgctcc     2100

tgcccacggg gcactcaggg tgtgcactgt gagatcaacg tggacgactg caatcccccc     2160

gttgaccccg tgtcccggag ccccaagtgc tttaacaacg gcacctgcgt ggaccaggtg     2220

ggcggctaca gctgcacctg cccgccgggc ttcgtgggtg agcgctgtga gggggatgtc     2280

aacgagtgcc tgtccaatcc ctgcgacgcc cgtggcaccc agaactgcgt gcagcgcgtc     2340

aatgacttcc actgcgagtg ccgtgctggt cacaccgggc gccgctgcga gtccgtcatc     2400

aatggctgca aaggcaagcc ctgcaagaat gggggcacct gcgccgtggc ctccaacacc     2460

gcccgcgggt tcatctgcaa gtgccctgcg ggcttcgagg gcgccacgtg tgagaatgac     2520

gctcgtacct gcggcagcct gcgctgcctc aacggcggca catgcatctc cggcccgcgc     2580

agccccacct gcctgtgcct gggccccttc acgggccccg aatgccagtt cccggccagc     2640

agcccctgcc tgggcggcaa cccctgctac aaccagggga cctgtgagcc cacatccgag     2700

agccccttct accgttgcct gtgccccgcc aaattcaacg ggctcttgtg ccacatcctg     2760

gactacagct tcggagatct gggcccgggc gagcccaaat cttgtgacaa aactcacaca     2820

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca     2880

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac     2940

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     3000

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     3060

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     3120

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     3180

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg     3240

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     3300

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     3360

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     3420

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     3480

ggtaaatga                                                             3489


<210>  9
<211>  1162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Notch1 Decoy 14-36

<400>  9

Met Pro Pro Leu Leu Ala Pro Leu Leu Cys Leu Ala Leu Leu Pro Ala 
1               5                   10                  15      


Leu Ala Ala Arg Gly Pro Arg Cys Ala Ser Thr Pro Cys Lys Asn Gly 
            20                  25                  30          


Ala Lys Cys Leu Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu 
        35                  40                  45              


Gly Tyr Thr Gly Thr His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro 
    50                  55                  60                  


Asp Pro Cys His Tyr Gly Ser Cys Lys Asp Gly Val Ala Thr Phe Thr 
65                  70                  75                  80  


Cys Leu Cys Arg Pro Gly Tyr Thr Gly His His Cys Glu Thr Asn Ile 
                85                  90                  95      


Asn Glu Cys Ser Ser Gln Pro Cys Arg His Gly Gly Thr Cys Gln Asp 
            100                 105                 110         


Arg Asp Asn Ala Tyr Leu Cys Phe Cys Leu Lys Gly Thr Thr Gly Pro 
        115                 120                 125             


Asn Cys Glu Ile Asn Leu Asp Asp Cys Ala Ser Ser Pro Cys Asp Ser 
    130                 135                 140                 


Gly Thr Cys Leu Asp Lys Ile Asp Gly Tyr Glu Cys Ala Cys Glu Pro 
145                 150                 155                 160 


Gly Tyr Thr Gly Ser Met Cys Asn Ile Asn Ile Asp Glu Cys Ala Gly 
                165                 170                 175     


Asn Pro Cys His Asn Gly Gly Thr Cys Glu Asp Gly Ile Asn Gly Phe 
            180                 185                 190         


Thr Cys Arg Cys Pro Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu 
        195                 200                 205             


Val Asn Glu Cys Asn Ser Asn Pro Cys Val His Gly Ala Cys Arg Asp 
    210                 215                 220                 


Ser Leu Asn Gly Tyr Lys Cys Asp Cys Asp Pro Gly Trp Ser Gly Thr 
225                 230                 235                 240 


Asn Cys Asp Ile Asn Asn Asn Glu Cys Glu Ser Asn Pro Cys Val Asn 
                245                 250                 255     


Gly Gly Thr Cys Lys Asp Met Thr Ser Gly Tyr Val Cys Thr Cys Arg 
            260                 265                 270         


Glu Gly Phe Ser Gly Pro Asn Cys Gln Thr Asn Ile Asn Glu Cys Ala 
        275                 280                 285             


Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Ile Asp Asp Val Ala Gly 
    290                 295                 300                 


Tyr Lys Cys Asn Cys Leu Leu Pro Tyr Thr Gly Ala Thr Cys Glu Val 
305                 310                 315                 320 


Val Leu Ala Pro Cys Ala Pro Ser Pro Cys Arg Asn Gly Gly Glu Cys 
                325                 330                 335     


Arg Gln Ser Glu Asp Tyr Glu Ser Phe Ser Cys Val Cys Pro Thr Gly 
            340                 345                 350         


Trp Gln Gly Gln Thr Cys Glu Val Asp Ile Asn Glu Cys Val Leu Ser 
        355                 360                 365             


Pro Cys Arg His Gly Ala Ser Cys Gln Asn Thr His Gly Gly Tyr Arg 
    370                 375                 380                 


Cys His Cys Gln Ala Gly Tyr Ser Gly Arg Asn Cys Glu Thr Asp Ile 
385                 390                 395                 400 


Asp Asp Cys Arg Pro Asn Pro Cys His Asn Gly Gly Ser Cys Thr Asp 
                405                 410                 415     


Gly Ile Asn Thr Ala Phe Cys Asp Cys Leu Pro Gly Phe Arg Gly Thr 
            420                 425                 430         


Phe Cys Glu Glu Asp Ile Asn Glu Cys Ala Ser Asp Pro Cys Arg Asn 
        435                 440                 445             


Gly Ala Asn Cys Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro 
    450                 455                 460                 


Ala Gly Phe Ser Gly Ile His Cys Glu Asn Asn Thr Pro Asp Cys Thr 
465                 470                 475                 480 


Glu Ser Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly Ile Asn Ser 
                485                 490                 495     


Phe Thr Cys Leu Cys Pro Pro Gly Phe Thr Gly Ser Tyr Cys Gln His 
            500                 505                 510         


Asp Val Asn Glu Cys Asp Ser Gln Pro Cys Leu His Gly Gly Thr Cys 
        515                 520                 525             


Gln Asp Gly Cys Gly Ser Tyr Arg Cys Thr Cys Pro Gln Gly Tyr Thr 
    530                 535                 540                 


Gly Pro Asn Cys Gln Asn Leu Val His Trp Cys Asp Ser Ser Pro Cys 
545                 550                 555                 560 


Lys Asn Gly Gly Lys Cys Trp Gln Thr His Thr Gln Tyr Arg Cys Glu 
                565                 570                 575     


Cys Pro Ser Gly Trp Thr Gly Leu Tyr Cys Asp Val Pro Ser Val Ser 
            580                 585                 590         


Cys Glu Val Ala Ala Gln Arg Gln Gly Val Asp Val Ala Arg Leu Cys 
        595                 600                 605             


Gln His Gly Gly Leu Cys Val Asp Ala Gly Asn Thr His His Cys Arg 
    610                 615                 620                 


Cys Gln Ala Gly Tyr Thr Gly Ser Tyr Cys Glu Asp Leu Val Asp Glu 
625                 630                 635                 640 


Cys Ser Pro Ser Pro Cys Gln Asn Gly Ala Thr Cys Thr Asp Tyr Leu 
                645                 650                 655     


Gly Gly Tyr Ser Cys Lys Cys Val Ala Gly Tyr His Gly Val Asn Cys 
            660                 665                 670         


Ser Glu Glu Ile Asp Glu Cys Leu Ser His Pro Cys Gln Asn Gly Gly 
        675                 680                 685             


Thr Cys Leu Asp Leu Pro Asn Thr Tyr Lys Cys Ser Cys Pro Arg Gly 
    690                 695                 700                 


Thr Gln Gly Val His Cys Glu Ile Asn Val Asp Asp Cys Asn Pro Pro 
705                 710                 715                 720 


Val Asp Pro Val Ser Arg Ser Pro Lys Cys Phe Asn Asn Gly Thr Cys 
                725                 730                 735     


Val Asp Gln Val Gly Gly Tyr Ser Cys Thr Cys Pro Pro Gly Phe Val 
            740                 745                 750         


Gly Glu Arg Cys Glu Gly Asp Val Asn Glu Cys Leu Ser Asn Pro Cys 
        755                 760                 765             


Asp Ala Arg Gly Thr Gln Asn Cys Val Gln Arg Val Asn Asp Phe His 
    770                 775                 780                 


Cys Glu Cys Arg Ala Gly His Thr Gly Arg Arg Cys Glu Ser Val Ile 
785                 790                 795                 800 


Asn Gly Cys Lys Gly Lys Pro Cys Lys Asn Gly Gly Thr Cys Ala Val 
                805                 810                 815     


Ala Ser Asn Thr Ala Arg Gly Phe Ile Cys Lys Cys Pro Ala Gly Phe 
            820                 825                 830         


Glu Gly Ala Thr Cys Glu Asn Asp Ala Arg Thr Cys Gly Ser Leu Arg 
        835                 840                 845             


Cys Leu Asn Gly Gly Thr Cys Ile Ser Gly Pro Arg Ser Pro Thr Cys 
    850                 855                 860                 


Leu Cys Leu Gly Pro Phe Thr Gly Pro Glu Cys Gln Phe Pro Ala Ser 
865                 870                 875                 880 


Ser Pro Cys Leu Gly Gly Asn Pro Cys Tyr Asn Gln Gly Thr Cys Glu 
                885                 890                 895     


Pro Thr Ser Glu Ser Pro Phe Tyr Arg Cys Leu Cys Pro Ala Lys Phe 
            900                 905                 910         


Asn Gly Leu Leu Cys His Ile Leu Asp Tyr Ser Phe Gly Asp Leu Gly 
        915                 920                 925             


Pro Gly Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    930                 935                 940                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
945                 950                 955                 960 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                965                 970                 975     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            980                 985                 990         


Tyr Val Asp Gly Val Glu Val His  Asn Ala Lys Thr Lys  Pro Arg Glu 
        995                 1000                 1005             


Glu Gln  Tyr Asn Ser Thr Tyr  Arg Val Val Ser Val  Leu Thr Val 
    1010                 1015                 1020             


Leu His  Gln Asp Trp Leu Asn  Gly Lys Glu Tyr Lys  Cys Lys Val 
    1025                 1030                 1035             


Ser Asn  Lys Ala Leu Pro Ala  Pro Ile Glu Lys Thr  Ile Ser Lys 
    1040                 1045                 1050             


Ala Lys  Gly Gln Pro Arg Glu  Pro Gln Val Tyr Thr  Leu Pro Pro 
    1055                 1060                 1065             


Ser Arg  Glu Glu Met Thr Lys  Asn Gln Val Ser Leu  Thr Cys Leu 
    1070                 1075                 1080             


Val Lys  Gly Phe Tyr Pro Ser  Asp Ile Ala Val Glu  Trp Glu Ser 
    1085                 1090                 1095             


Asn Gly  Gln Pro Glu Asn Asn  Tyr Lys Thr Thr Pro  Pro Val Leu 
    1100                 1105                 1110             


Asp Ser  Asp Gly Ser Phe Phe  Leu Tyr Ser Lys Leu  Thr Val Asp 
    1115                 1120                 1125             


Lys Ser  Arg Trp Gln Gln Gly  Asn Val Phe Ser Cys  Ser Val Met 
    1130                 1135                 1140             


His Glu  Ala Leu His Asn His  Tyr Thr Gln Lys Ser  Leu Ser Leu 
    1145                 1150                 1155             


Ser Pro  Gly Lys 
    1160         


