                         SEQUENCE LISTING

<110>  ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
 
<120>  CASPASE 9 INHIBITION AND BRI2 PEPTIDES FOR TREATING DEMENTIA

<130>  96700_1902

<140>  PCT/US2012/058480
<141>  2012-10-02

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  266
<212>  PRT
<213>  HOMO SAPIENS

<400>  1

Met Val Lys Val Thr Phe Asn Ser Ala Leu Ala Gln Lys Glu Ala Lys 
1               5                   10                  15      


Lys Asp Glu Pro Lys Ser Gly Glu Glu Ala Leu Ile Ile Pro Pro Asp 
            20                  25                  30          


Ala Val Ala Val Asp Cys Lys Asp Pro Asp Asp Val Val Pro Val Gly 
        35                  40                  45              


Gln Arg Arg Ala Trp Cys Trp Cys Met Cys Phe Gly Leu Ala Phe Met 
    50                  55                  60                  


Leu Ala Gly Val Ile Leu Gly Gly Ala Tyr Leu Tyr Lys Tyr Phe Ala 
65                  70                  75                  80  


Leu Gln Pro Asp Asp Val Tyr Tyr Cys Gly Ile Lys Tyr Ile Lys Asp 
                85                  90                  95      


Asp Val Ile Leu Asn Glu Pro Ser Ala Asp Ala Pro Ala Ala Leu Tyr 
            100                 105                 110         


Gln Thr Ile Glu Glu Asn Ile Lys Ile Phe Glu Glu Glu Glu Val Glu 
        115                 120                 125             


Phe Ile Ser Val Pro Val Pro Glu Phe Ala Asp Ser Asp Pro Ala Asn 
    130                 135                 140                 


Ile Val His Asp Phe Asn Lys Lys Leu Thr Ala Tyr Leu Asp Leu Asn 
145                 150                 155                 160 


Leu Asp Lys Cys Tyr Val Ile Pro Leu Asn Thr Ser Ile Val Met Pro 
                165                 170                 175     


Pro Arg Asn Leu Leu Glu Leu Leu Ile Asn Ile Lys Ala Gly Thr Tyr 
            180                 185                 190         


Leu Pro Gln Ser Tyr Leu Ile His Glu His Met Val Ile Thr Asp Arg 
        195                 200                 205             


Ile Glu Asn Ile Asp His Leu Gly Phe Phe Ile Tyr Arg Leu Cys His 
    210                 215                 220                 


Asp Lys Glu Thr Tyr Lys Leu Gln Arg Arg Glu Thr Ile Lys Gly Ile 
225                 230                 235                 240 


Gln Lys Arg Glu Ala Ser Asn Cys Phe Ala Ile Arg His Phe Glu Asn 
                245                 250                 255     


Lys Phe Ala Val Glu Thr Leu Ile Cys Ser 
            260                 265     


<210>  2
<211>  10
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  FRAGMENT DIRECTED TO A HOMO SAPIENS PROTEIN

<400>  2

Tyr Leu Tyr Lys Tyr Phe Ala Leu Gln Pro 
1               5                   10  


<210>  3
<211>  10
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  FRAGMENT DIRECTED TO A HOMO SAPIENS PROTEIN

<400>  3

Phe Ala Leu Gln Pro Asp Asp Val Tyr Tyr 
1               5                   10  


<210>  4
<211>  10
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  FRAGMENT DIRECTED TO A HOMO SAPIENS PROTEIN

<400>  4

Asp Asp Val Tyr Tyr Cys Gly Leu Lys Tyr 
1               5                   10  


<210>  5
<211>  10
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  FRAGMENT DIRECTED TO A HOMO SAPIENS PROTEIN

<400>  5

Asp Ala Val Tyr Tyr Cys Gly Leu Lys Tyr 
1               5                   10  


<210>  6
<211>  10
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  FRAGMENT DIRECTED TO A HOMO SAPIENS PROTEIN

<400>  6

Cys Gly Leu Lys Tyr Ile Lys Asp Asp Val 
1               5                   10  


<210>  7
<211>  10
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  FRAGMENT DIRECTED TO HOMO SAPIENS PROTEIN

<400>  7

Ile Lys Asp Asp Val Ile Leu Asn Glu Pro 
1               5                   10  


<210>  8
<211>  10
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  FRAGMENT DIRECTED TO HUMAN PROTEIN

<400>  8

Ile Leu Asn Glu Pro Ser Ala Asp Ala Pro 
1               5                   10  


<210>  9
<211>  14
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  FRAGMENT DIRECTED TO HUMAN PROTEIN

<400>  9

Asp Asp Val Tyr Tyr Cys Gly Leu Lys Tyr Ile Lys Asp Asp 
1               5                   10                  


<210>  10
<211>  10
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  FRAGMENT DIRECTED TO HUMAN PROTEIN


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X = D or A

<400>  10

Asp Xaa Val Tyr Tyr Cys Gly Leu Lys Tyr 
1               5                   10  


<210>  11
<211>  4
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CHEMICALLY SYNTHESIZED

<400>  11

Leu Glu His Asp 
1               


<210>  12
<211>  10
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  FRAGMENT DIRECTED TO HOMO SAPIENS PROTEIN

<400>  12

Ala Asp Val Tyr Tyr Cys Gly Leu Lys Tyr 
1               5                   10  


<210>  13
<211>  4
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CHEMICALLY SYNTHESIZED


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  OMe attached

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  OMe attached

<400>  13

Leu Glu His Asp 
1               


<210>  14
<211>  4
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CHEMICALLY SYNTHESIZED


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  OMe attached

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  OMe attached

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  OMe attached

<400>  14

Asp Glu Val Asp 
1               


<210>  15
<211>  116
<212>  PRT
<213>  HOMO SAPIENS

<400>  15

Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 
1               5                   10                  15      


Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 
            20                  25                  30          


Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 
        35                  40                  45              


Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 
    50                  55                  60                  


Gly Gly Leu Thr Asp Trp Lys Pro Ser Glu Asp Pro Trp Glu Gln His 
65                  70                  75                  80  


Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 
                85                  90                  95      


Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser Leu Glu Glu Cys Leu 
            100                 105                 110         


Val Arg Thr Thr 
        115     


<210>  16
<211>  497
<212>  PRT
<213>  HOMO SAPIENS

<400>  16

Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp 
1               5                   10                  15      


Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 
            20                  25                  30          


Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 
        35                  40                  45              


Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 
    50                  55                  60                  


Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val 
65                  70                  75                  80  


Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly Phe 
                85                  90                  95      


Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile Gln Asn 
            100                 105                 110         


Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala 
        115                 120                 125             


Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 
    130                 135                 140                 


Gln Val Val Asp Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met 
145                 150                 155                 160 


Tyr Ser Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 
                165                 170                 175     


Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 
            180                 185                 190         


Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 
        195                 200                 205             


Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg His Phe 
    210                 215                 220                 


Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg Ser Glu 
225                 230                 235                 240 


Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 
                245                 250                 255     


Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 
            260                 265                 270         


Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 
        275                 280                 285             


Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 
    290                 295                 300                 


Gly Gly Leu Thr Asp Trp Lys Pro Ser Glu Asp Pro Trp Glu Gln His 
305                 310                 315                 320 


Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 
                325                 330                 335     


Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser Leu Glu Glu Cys Leu 
            340                 345                 350         


Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp 
        355                 360                 365             


Thr Ile Phe Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 
    370                 375                 380                 


Ser Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser 
385                 390                 395                 400 


Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 
                405                 410                 415     


Ala Gln Lys Asp Ser Met Gln Asp Glu Ser Ser Gln Thr Ser Leu Gln 
            420                 425                 430         


Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 
        435                 440                 445             


Leu Cys Lys Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe Val Pro 
    450                 455                 460                 


Cys Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu Ala Val Asp Lys 
465                 470                 475                 480 


Cys Pro Met Cys Tyr Thr Val Ile Thr Phe Lys Gln Lys Ile Phe Met 
                485                 490                 495     


Ser 
    


<210>  17
<211>  116
<212>  PRT
<213>  HOMO SAPIENS

<400>  17

Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 
1               5                   10                  15      


Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 
            20                  25                  30          


Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 
        35                  40                  45              


Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 
    50                  55                  60                  


Gly Gly Leu Thr Asp Trp Lys Pro Ser Glu Asp Pro Trp Glu Gln His 
65                  70                  75                  80  


Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 
                85                  90                  95      


Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser Leu Glu Glu Cys Leu 
            100                 105                 110         


Val Arg Thr Thr 
        115     


<210>  18
<211>  16
<212>  PRT
<213>  DROSOPHILA

<400>  18

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


