                         SEQUENCE LISTING

<110>  University of Bremen
 
<120>  WNT4 AND MED12 FOR USE IN THE DIAGNOSIS AND TREATMENT OF TUMOR 
       DISEASES

<130>  UN15A12/P-WO

<150>  EP 11 183 963.5
<151>  2011-10-05

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  6985
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (200)..(6730)
<223>  coding sequence of Med12

<220>
<221>  misc_feature
<222>  (326)..(331)
<223>  Nucleotides c.127 to c.132 (CAA GGT) encoding codons 43 (Q) to 44
       (G) of the Med12-gene

<300>
<308>  NM_005120.2
<309>  2011-09-18
<313>  (1)..(6985)

<400>  1
attgtccgat ggttcccggc gtacctcggc ttccctcggt agtttccggc aatggtcgag       60

agtttctaac gtgccccctt gttgtctctc ggccgccgtc ctctcaacca ccgcccccct      120

tttcggctcc ctctccccct tcccgttccc ccagtcagcc tggccctgct ggtgcctccg      180

gcgctacggg ctgggcaag atg gcg gcc ttc ggg atc ttg agc tac gaa cac       232
                     Met Ala Ala Phe Gly Ile Leu Ser Tyr Glu His          
                     1               5                   10               

cgg ccc ctg aag cgg ccg cgg ctg ggg cct ccc gat gtt tac cct cag        280
Arg Pro Leu Lys Arg Pro Arg Leu Gly Pro Pro Asp Val Tyr Pro Gln           
            15                  20                  25                    

gac ccc aaa cag aag gag gat gaa ctg acg gcc ttg aat gta aaa caa        328
Asp Pro Lys Gln Lys Glu Asp Glu Leu Thr Ala Leu Asn Val Lys Gln           
        30                  35                  40                        

ggt ttc aat aac cag cct gct gtc tct ggg gat gag cat ggc agt gcc        376
Gly Phe Asn Asn Gln Pro Ala Val Ser Gly Asp Glu His Gly Ser Ala           
    45                  50                  55                            

aag aac gtc agc ttc aat cct gcc aag atc agt tcc aac ttc agc agc        424
Lys Asn Val Ser Phe Asn Pro Ala Lys Ile Ser Ser Asn Phe Ser Ser           
60                  65                  70                  75            

att att gca gag aaa tta cgt tgt aat acc ctt cct gac act ggt cgc        472
Ile Ile Ala Glu Lys Leu Arg Cys Asn Thr Leu Pro Asp Thr Gly Arg           
                80                  85                  90                

agg aag ccc caa gtg aac cag aag gat aac ttc tgg ctg gtg act gca        520
Arg Lys Pro Gln Val Asn Gln Lys Asp Asn Phe Trp Leu Val Thr Ala           
            95                  100                 105                   

cga tcc cag agt gcc att aac act tgg ttc act gac ttg gct ggc acc        568
Arg Ser Gln Ser Ala Ile Asn Thr Trp Phe Thr Asp Leu Ala Gly Thr           
        110                 115                 120                       

aag cca ctc acg caa cta gcc aaa aag gtc ccc att ttc agt aag aag        616
Lys Pro Leu Thr Gln Leu Ala Lys Lys Val Pro Ile Phe Ser Lys Lys           
    125                 130                 135                           

gaa gag gtg ttt ggg tac tta gcc aaa tac aca gtg cct gtg atg cgg        664
Glu Glu Val Phe Gly Tyr Leu Ala Lys Tyr Thr Val Pro Val Met Arg           
140                 145                 150                 155           

gct gcc tgg ctc att aag atg acc tgt gcc tac tat gca gca atc tct        712
Ala Ala Trp Leu Ile Lys Met Thr Cys Ala Tyr Tyr Ala Ala Ile Ser           
                160                 165                 170               

gag acc aag gtt aag aag aga cat gtt gac cct ttc atg gaa tgg act        760
Glu Thr Lys Val Lys Lys Arg His Val Asp Pro Phe Met Glu Trp Thr           
            175                 180                 185                   

cag atc atc acc aag tac tta tgg gag cag tta cag aag atg gct gaa        808
Gln Ile Ile Thr Lys Tyr Leu Trp Glu Gln Leu Gln Lys Met Ala Glu           
        190                 195                 200                       

tac tac cgg cca ggg cct gca gga agt ggg ggc tgt ggt tcc acg ata        856
Tyr Tyr Arg Pro Gly Pro Ala Gly Ser Gly Gly Cys Gly Ser Thr Ile           
    205                 210                 215                           

ggg ccc ttg ccc cat gat gta gag gtg gca atc cgg cag tgg gat tac        904
Gly Pro Leu Pro His Asp Val Glu Val Ala Ile Arg Gln Trp Asp Tyr           
220                 225                 230                 235           

acc gag aag ctg gcc atg ttc atg ttt cag gat gga atg ctg gac aga        952
Thr Glu Lys Leu Ala Met Phe Met Phe Gln Asp Gly Met Leu Asp Arg           
                240                 245                 250               

cat gag ttc ctg acc tgg gtg ctt gag tgt ttt gag aag atc cgc cct       1000
His Glu Phe Leu Thr Trp Val Leu Glu Cys Phe Glu Lys Ile Arg Pro           
            255                 260                 265                   

gga gag gat gaa ttg ctt aaa ctg ctg ctg cct ctg ctt ctc cga tac       1048
Gly Glu Asp Glu Leu Leu Lys Leu Leu Leu Pro Leu Leu Leu Arg Tyr           
        270                 275                 280                       

tct ggg gaa ttt gtt cag tct gca tac ctg tcc cgc cgg ctt gcc tac       1096
Ser Gly Glu Phe Val Gln Ser Ala Tyr Leu Ser Arg Arg Leu Ala Tyr           
    285                 290                 295                           

ttc tgt aca cgg aga ctg gcc ctg cag ctg gat ggt gtg agc agt cac       1144
Phe Cys Thr Arg Arg Leu Ala Leu Gln Leu Asp Gly Val Ser Ser His           
300                 305                 310                 315           

tca tct cat gtt ata tct gct cag tca aca agc acg cta ccc acc acc       1192
Ser Ser His Val Ile Ser Ala Gln Ser Thr Ser Thr Leu Pro Thr Thr           
                320                 325                 330               

cct gct cct cag ccc cca act agc agc aca ccc tcg act ccc ttt agt       1240
Pro Ala Pro Gln Pro Pro Thr Ser Ser Thr Pro Ser Thr Pro Phe Ser           
            335                 340                 345                   

gac ctg ctt atg tgc cct cag cac cgg ccc ctg gtt ttt ggc ctc agc       1288
Asp Leu Leu Met Cys Pro Gln His Arg Pro Leu Val Phe Gly Leu Ser           
        350                 355                 360                       

tgt atc cta cag acc atc ctc ctg tgc tgt cct agt gcc ttg gtt tgg       1336
Cys Ile Leu Gln Thr Ile Leu Leu Cys Cys Pro Ser Ala Leu Val Trp           
    365                 370                 375                           

cac tac tca ctg act gat agc aga att aag acc ggc tca cca ctt gac       1384
His Tyr Ser Leu Thr Asp Ser Arg Ile Lys Thr Gly Ser Pro Leu Asp           
380                 385                 390                 395           

cac ttg cct att gcc ccg tcc aac ctg ccc atg cca gag ggt aac agt       1432
His Leu Pro Ile Ala Pro Ser Asn Leu Pro Met Pro Glu Gly Asn Ser           
                400                 405                 410               

gcc ttc act cag cag gtc cgt gca aag ttg cgg gag atc gag cag cag       1480
Ala Phe Thr Gln Gln Val Arg Ala Lys Leu Arg Glu Ile Glu Gln Gln           
            415                 420                 425                   

atc aag gag cgg gga cag gca gtt gaa gtt cgc tgg tct ttc gat aaa       1528
Ile Lys Glu Arg Gly Gln Ala Val Glu Val Arg Trp Ser Phe Asp Lys           
        430                 435                 440                       

tgc cag gaa gct act gca ggc ttc acc att gga cgg gta ctt cat act       1576
Cys Gln Glu Ala Thr Ala Gly Phe Thr Ile Gly Arg Val Leu His Thr           
    445                 450                 455                           

ttg gaa gtg ctg gac agc cat agt ttt gaa cgc tct gac ttc agc aac       1624
Leu Glu Val Leu Asp Ser His Ser Phe Glu Arg Ser Asp Phe Ser Asn           
460                 465                 470                 475           

tct ctt gac tcc ctt tgt aac cga atc ttt gga ttg gga cct agc aag       1672
Ser Leu Asp Ser Leu Cys Asn Arg Ile Phe Gly Leu Gly Pro Ser Lys           
                480                 485                 490               

gat ggg cat gag atc tcc tca gat gat gat gct gtg gtg tca ttg cta       1720
Asp Gly His Glu Ile Ser Ser Asp Asp Asp Ala Val Val Ser Leu Leu           
            495                 500                 505                   

tgt gaa tgg gct gtc agc tgc aag cgt tct ggt cgg cat cgt gct atg       1768
Cys Glu Trp Ala Val Ser Cys Lys Arg Ser Gly Arg His Arg Ala Met           
        510                 515                 520                       

gtg gta gcc aag ctc ctg gag aag aga cag gcg gag att gag gct gag       1816
Val Val Ala Lys Leu Leu Glu Lys Arg Gln Ala Glu Ile Glu Ala Glu           
    525                 530                 535                           

cgt tgt gga gaa tca gaa gcc gca gat gag aag ggt tcc atc gcc tct       1864
Arg Cys Gly Glu Ser Glu Ala Ala Asp Glu Lys Gly Ser Ile Ala Ser           
540                 545                 550                 555           

ggc tcc ctt tct gct ccc agt gct ccc att ttc cag gat gtc ctc ctg       1912
Gly Ser Leu Ser Ala Pro Ser Ala Pro Ile Phe Gln Asp Val Leu Leu           
                560                 565                 570               

cag ttt ctg gat aca cag gct ccc atg ctg acg gac cct cga agt gag       1960
Gln Phe Leu Asp Thr Gln Ala Pro Met Leu Thr Asp Pro Arg Ser Glu           
            575                 580                 585                   

agt gag cgg gtg gaa ttc ttt aac tta gta ctg ctg ttc tgt gaa ctg       2008
Ser Glu Arg Val Glu Phe Phe Asn Leu Val Leu Leu Phe Cys Glu Leu           
        590                 595                 600                       

att cga cat gat gtt ttc tcc cac aac atg tat act tgc act ctc atc       2056
Ile Arg His Asp Val Phe Ser His Asn Met Tyr Thr Cys Thr Leu Ile           
    605                 610                 615                           

tcc cga ggg gac ctt gcc ttt gga gcc cct ggt ccc cgg cct ccc tct       2104
Ser Arg Gly Asp Leu Ala Phe Gly Ala Pro Gly Pro Arg Pro Pro Ser           
620                 625                 630                 635           

ccc ttt gat gat cct gcc gat gac cca gag cac aag gag gct gaa ggc       2152
Pro Phe Asp Asp Pro Ala Asp Asp Pro Glu His Lys Glu Ala Glu Gly           
                640                 645                 650               

agc agc agc agc aag ctg gaa gat cca ggg ctc tca gaa tct atg gac       2200
Ser Ser Ser Ser Lys Leu Glu Asp Pro Gly Leu Ser Glu Ser Met Asp           
            655                 660                 665                   

att gac cct agt tcc agt gtt ctc ttt gag gac atg gag aag cct gat       2248
Ile Asp Pro Ser Ser Ser Val Leu Phe Glu Asp Met Glu Lys Pro Asp           
        670                 675                 680                       

ttc tca ttg ttc tcc cct act atg ccc tgt gag ggg aag ggc agt cca       2296
Phe Ser Leu Phe Ser Pro Thr Met Pro Cys Glu Gly Lys Gly Ser Pro           
    685                 690                 695                           

tcc cct gag aag cca gat gtc gag aag gag gtg aag ccc cca ccc aag       2344
Ser Pro Glu Lys Pro Asp Val Glu Lys Glu Val Lys Pro Pro Pro Lys           
700                 705                 710                 715           

gag aag att gaa ggg acc ctt ggg gtt ctt tac gac cag cca cga cac       2392
Glu Lys Ile Glu Gly Thr Leu Gly Val Leu Tyr Asp Gln Pro Arg His           
                720                 725                 730               

gtg cag tac gcc acc cat ttt ccc atc ccc cag gag gag tca tgc agc       2440
Val Gln Tyr Ala Thr His Phe Pro Ile Pro Gln Glu Glu Ser Cys Ser           
            735                 740                 745                   

cat gag tgc aac cag cgg ttg gtc gta ctg ttt ggg gtg gga aag cag       2488
His Glu Cys Asn Gln Arg Leu Val Val Leu Phe Gly Val Gly Lys Gln           
        750                 755                 760                       

cga gat gat gcc cgc cat gcc atc aag aaa atc acc aag gat atc ttg       2536
Arg Asp Asp Ala Arg His Ala Ile Lys Lys Ile Thr Lys Asp Ile Leu           
    765                 770                 775                           

aag gtt ctg aac cgc aaa ggg aca gca gaa act gac cag ctt gct cct       2584
Lys Val Leu Asn Arg Lys Gly Thr Ala Glu Thr Asp Gln Leu Ala Pro           
780                 785                 790                 795           

att gtg cct ctg aat cct gga gac ctg aca ttc tta ggt ggg gag gat       2632
Ile Val Pro Leu Asn Pro Gly Asp Leu Thr Phe Leu Gly Gly Glu Asp           
                800                 805                 810               

ggg cag aag cgg cga cgc aac cgg cct gaa gcc ttc ccc act gct gaa       2680
Gly Gln Lys Arg Arg Arg Asn Arg Pro Glu Ala Phe Pro Thr Ala Glu           
            815                 820                 825                   

gat atc ttt gct aag ttc cag cac ctt tca cat tat gac caa cac cag       2728
Asp Ile Phe Ala Lys Phe Gln His Leu Ser His Tyr Asp Gln His Gln           
        830                 835                 840                       

gtc acg gct cag gtc tcc cgg aat gtt ctg gag cag atc acg agc ttt       2776
Val Thr Ala Gln Val Ser Arg Asn Val Leu Glu Gln Ile Thr Ser Phe           
    845                 850                 855                           

gcc ctt ggc atg tca tac cac ttg cct ctg gtg cag cat gtg cag ttc       2824
Ala Leu Gly Met Ser Tyr His Leu Pro Leu Val Gln His Val Gln Phe           
860                 865                 870                 875           

atc ttc gac ctc atg gaa tat tca ctc agc atc agt ggc ctc atc gac       2872
Ile Phe Asp Leu Met Glu Tyr Ser Leu Ser Ile Ser Gly Leu Ile Asp           
                880                 885                 890               

ttt gcc att cag ctg ctg aat gaa ctg agt gta gtt gag gct gag ctg       2920
Phe Ala Ile Gln Leu Leu Asn Glu Leu Ser Val Val Glu Ala Glu Leu           
            895                 900                 905                   

ctt ctc aaa tcc tcg gat ctg gtg ggc agc tac act act agc ctg tgc       2968
Leu Leu Lys Ser Ser Asp Leu Val Gly Ser Tyr Thr Thr Ser Leu Cys           
        910                 915                 920                       

ctg tgc atc gtg gct gtc ctg cgg cac tat cat gcc tgc ctc atc ctc       3016
Leu Cys Ile Val Ala Val Leu Arg His Tyr His Ala Cys Leu Ile Leu           
    925                 930                 935                           

aac cag gac cag atg gca cag gtc ttt gag ggg ctg tgt ggc gtc gtg       3064
Asn Gln Asp Gln Met Ala Gln Val Phe Glu Gly Leu Cys Gly Val Val           
940                 945                 950                 955           

aag cat ggg atg aac cgg tcc gat ggc tcc tct gca gag cgc tgt atc       3112
Lys His Gly Met Asn Arg Ser Asp Gly Ser Ser Ala Glu Arg Cys Ile           
                960                 965                 970               

ctt gct tat ctc tat gat ctg tac acc tcc tgt agc cat tta aag aac       3160
Leu Ala Tyr Leu Tyr Asp Leu Tyr Thr Ser Cys Ser His Leu Lys Asn           
            975                 980                 985                   

aaa ttt ggg gag ctc ttc agc gac ttt tgc tca aag gtg  aag aac acc      3208
Lys Phe Gly Glu Leu Phe Ser Asp Phe Cys Ser Lys Val  Lys Asn Thr          
        990                 995                 1000                      

atc tac  tgc aac gtg gag cca  tcg gaa tca aat atg  cgc tgg gca        3253
Ile Tyr  Cys Asn Val Glu Pro  Ser Glu Ser Asn Met  Arg Trp Ala            
    1005                 1010                 1015                        

cct gag  ttc atg atc gac act  cta gag aac cct gca  gct cac acc        3298
Pro Glu  Phe Met Ile Asp Thr  Leu Glu Asn Pro Ala  Ala His Thr            
    1020                 1025                 1030                        

ttc acc  tac acg ggg cta ggc  aag agt ctt agt gag  aac cct gct        3343
Phe Thr  Tyr Thr Gly Leu Gly  Lys Ser Leu Ser Glu  Asn Pro Ala            
    1035                 1040                 1045                        

aac cgc  tac agc ttt gtc tgc  aat gcc ctt atg cac  gtc tgt gtg        3388
Asn Arg  Tyr Ser Phe Val Cys  Asn Ala Leu Met His  Val Cys Val            
    1050                 1055                 1060                        

ggg cac  cat gat ccc gat agg  gtg aat gac atc gca  atc ctg tgt        3433
Gly His  His Asp Pro Asp Arg  Val Asn Asp Ile Ala  Ile Leu Cys            
    1065                 1070                 1075                        

gca gag  ctg acc ggc tat tgc  aag tca ctg agt gca  gaa tgg cta        3478
Ala Glu  Leu Thr Gly Tyr Cys  Lys Ser Leu Ser Ala  Glu Trp Leu            
    1080                 1085                 1090                        

gga gtg  ctt aag gcc ttg tgc  tgc tcc tct aac aat  ggc act tgt        3523
Gly Val  Leu Lys Ala Leu Cys  Cys Ser Ser Asn Asn  Gly Thr Cys            
    1095                 1100                 1105                        

ggt ttc  aac gat ctc ctc tgc  aat gtt gat gtc agt  gac cta tct        3568
Gly Phe  Asn Asp Leu Leu Cys  Asn Val Asp Val Ser  Asp Leu Ser            
    1110                 1115                 1120                        

ttt cat  gac tcg ctg gct act  ttt gtt gcc atc ctc  atc gct cgg        3613
Phe His  Asp Ser Leu Ala Thr  Phe Val Ala Ile Leu  Ile Ala Arg            
    1125                 1130                 1135                        

cag tgt  ttg ctc ctg gaa gat  ctg att cgc tgt gct  gcc atc cct        3658
Gln Cys  Leu Leu Leu Glu Asp  Leu Ile Arg Cys Ala  Ala Ile Pro            
    1140                 1145                 1150                        

tca ctc  ctt aat gct gct tgt  agt gaa cag gac tct  gag cca ggg        3703
Ser Leu  Leu Asn Ala Ala Cys  Ser Glu Gln Asp Ser  Glu Pro Gly            
    1155                 1160                 1165                        

gcc cgg  ctt acc tgc cgc atc  ctc ctt cac ctt ttc  aag aca ccg        3748
Ala Arg  Leu Thr Cys Arg Ile  Leu Leu His Leu Phe  Lys Thr Pro            
    1170                 1175                 1180                        

cag ctc  aat cct tgc cag tct  gat gga aac aag cct  aca gta gga        3793
Gln Leu  Asn Pro Cys Gln Ser  Asp Gly Asn Lys Pro  Thr Val Gly            
    1185                 1190                 1195                        

atc cgc  tcc tcc tgc gac cgc  cac ctg ctg gct gcc  tcc cag aac        3838
Ile Arg  Ser Ser Cys Asp Arg  His Leu Leu Ala Ala  Ser Gln Asn            
    1200                 1205                 1210                        

cgc atc  gtg gat gga gcc gtg  ttt gct gtt ctc aag  gct gtg ttt        3883
Arg Ile  Val Asp Gly Ala Val  Phe Ala Val Leu Lys  Ala Val Phe            
    1215                 1220                 1225                        

gta ctt  ggg gat gcg gaa ctg  aaa ggt tca ggc ttc  act gtg aca        3928
Val Leu  Gly Asp Ala Glu Leu  Lys Gly Ser Gly Phe  Thr Val Thr            
    1230                 1235                 1240                        

gga gga  aca gaa gaa ctt cca  gag gag gag gga gga  ggt ggc agt        3973
Gly Gly  Thr Glu Glu Leu Pro  Glu Glu Glu Gly Gly  Gly Gly Ser            
    1245                 1250                 1255                        

ggt ggt  cgg agg cag ggt ggc  cgc aac atc tct gtg  gag aca gcc        4018
Gly Gly  Arg Arg Gln Gly Gly  Arg Asn Ile Ser Val  Glu Thr Ala            
    1260                 1265                 1270                        

agt ctg  gat gtc tat gcc aag  tac gtg ctg cgc agc  atc tgc caa        4063
Ser Leu  Asp Val Tyr Ala Lys  Tyr Val Leu Arg Ser  Ile Cys Gln            
    1275                 1280                 1285                        

cag gaa  tgg gta gga gaa cgt  tgc ctt aag tct ctg  tgt gag gac        4108
Gln Glu  Trp Val Gly Glu Arg  Cys Leu Lys Ser Leu  Cys Glu Asp            
    1290                 1295                 1300                        

agc aat  gac ctg caa gac cca  gtg ttg agt agt gcc  cag gcg cag        4153
Ser Asn  Asp Leu Gln Asp Pro  Val Leu Ser Ser Ala  Gln Ala Gln            
    1305                 1310                 1315                        

cgc ctc  atg cag ctc att tgc  tat cca cat cga ctg  ctg gac aat        4198
Arg Leu  Met Gln Leu Ile Cys  Tyr Pro His Arg Leu  Leu Asp Asn            
    1320                 1325                 1330                        

gag gat  ggg gaa aac ccc cag  cgg cag cgc ata aag  cgc att ctc        4243
Glu Asp  Gly Glu Asn Pro Gln  Arg Gln Arg Ile Lys  Arg Ile Leu            
    1335                 1340                 1345                        

cag aac  ttg gac cag tgg acc  atg cgc cag tct tcc  ttg gag ctg        4288
Gln Asn  Leu Asp Gln Trp Thr  Met Arg Gln Ser Ser  Leu Glu Leu            
    1350                 1355                 1360                        

cag ctc  atg atc aag cag acc  cct aac aat gag atg  aac tcc ctc        4333
Gln Leu  Met Ile Lys Gln Thr  Pro Asn Asn Glu Met  Asn Ser Leu            
    1365                 1370                 1375                        

ttg gag  aac atc gcc aag gcc  aca atc gag gtt ttc  caa cag tca        4378
Leu Glu  Asn Ile Ala Lys Ala  Thr Ile Glu Val Phe  Gln Gln Ser            
    1380                 1385                 1390                        

gca gag  aca ggg tca tct tct  gga agt act gca agc  aac atg ccc        4423
Ala Glu  Thr Gly Ser Ser Ser  Gly Ser Thr Ala Ser  Asn Met Pro            
    1395                 1400                 1405                        

agc agc  agc aag acc aag cct  gtg ctc agc tct cta  gag cgc tct        4468
Ser Ser  Ser Lys Thr Lys Pro  Val Leu Ser Ser Leu  Glu Arg Ser            
    1410                 1415                 1420                        

ggt gta  tgg ctg gtg gcc ccc  ctc att gct aaa ctg  ccc acc tca        4513
Gly Val  Trp Leu Val Ala Pro  Leu Ile Ala Lys Leu  Pro Thr Ser            
    1425                 1430                 1435                        

gtc cag  gga cat gtg tta aag  gct gct ggg gaa gaa  ttg gag aag        4558
Val Gln  Gly His Val Leu Lys  Ala Ala Gly Glu Glu  Leu Glu Lys            
    1440                 1445                 1450                        

ggt cag  cac ctg ggt tcc tct  tca cgc aaa gaa cgt  gat cga caa        4603
Gly Gln  His Leu Gly Ser Ser  Ser Arg Lys Glu Arg  Asp Arg Gln            
    1455                 1460                 1465                        

aag cag  aag agc atg tcc cta  ttg agc cag cag ccc  ttc tta tcg        4648
Lys Gln  Lys Ser Met Ser Leu  Leu Ser Gln Gln Pro  Phe Leu Ser            
    1470                 1475                 1480                        

ctg gtg  cta aca tgt ctg aaa  ggg cag gat gaa caa  cgc gag gga        4693
Leu Val  Leu Thr Cys Leu Lys  Gly Gln Asp Glu Gln  Arg Glu Gly            
    1485                 1490                 1495                        

ctc ctt  acc tcc ctc tac agc  cag gtg cac cag att  gtg aat aat        4738
Leu Leu  Thr Ser Leu Tyr Ser  Gln Val His Gln Ile  Val Asn Asn            
    1500                 1505                 1510                        

tgg cga  gat gac cag tac tta  gat gat tgc aaa cca  aag cag ctt        4783
Trp Arg  Asp Asp Gln Tyr Leu  Asp Asp Cys Lys Pro  Lys Gln Leu            
    1515                 1520                 1525                        

atg cat  gag gca ctc aaa ctg  cgg ctc aac ctg gtg  ggg ggc atg        4828
Met His  Glu Ala Leu Lys Leu  Arg Leu Asn Leu Val  Gly Gly Met            
    1530                 1535                 1540                        

ttt gac  acg gtg cag cgc agc  acc cag cag acc acg  gag tgg gcc        4873
Phe Asp  Thr Val Gln Arg Ser  Thr Gln Gln Thr Thr  Glu Trp Ala            
    1545                 1550                 1555                        

atg ctc  ctc ctg gag atc atc  atc agc ggc act gtc  gac atg cag        4918
Met Leu  Leu Leu Glu Ile Ile  Ile Ser Gly Thr Val  Asp Met Gln            
    1560                 1565                 1570                        

tcc aac  aat gag ctc ttc act  act gtg ttg gac atg  ctg agc gtg        4963
Ser Asn  Asn Glu Leu Phe Thr  Thr Val Leu Asp Met  Leu Ser Val            
    1575                 1580                 1585                        

ctc atc  aat ggg aca ttg gct  gca gac atg tct agc  atc tcg caa        5008
Leu Ile  Asn Gly Thr Leu Ala  Ala Asp Met Ser Ser  Ile Ser Gln            
    1590                 1595                 1600                        

ggt agc  atg gag gaa aac aag  cgt gca tac atg aac  ctg gcg aag        5053
Gly Ser  Met Glu Glu Asn Lys  Arg Ala Tyr Met Asn  Leu Ala Lys            
    1605                 1610                 1615                        

aag ttg  cag aag gag ttg ggg  gag cgc cag tca gac  agt ctg gaa        5098
Lys Leu  Gln Lys Glu Leu Gly  Glu Arg Gln Ser Asp  Ser Leu Glu            
    1620                 1625                 1630                        

aag gtt  cgc cag ctg ctg cca  ctg ccc aag cag acc  cga gat gtc        5143
Lys Val  Arg Gln Leu Leu Pro  Leu Pro Lys Gln Thr  Arg Asp Val            
    1635                 1640                 1645                        

atc acg  tgt gag cca cag ggc  tcc ctt atc gat acc  aag ggc aac        5188
Ile Thr  Cys Glu Pro Gln Gly  Ser Leu Ile Asp Thr  Lys Gly Asn            
    1650                 1655                 1660                        

aag att  gct ggc ttc gat tcc  atc ttc aag aag gag  ggt cta cag        5233
Lys Ile  Ala Gly Phe Asp Ser  Ile Phe Lys Lys Glu  Gly Leu Gln            
    1665                 1670                 1675                        

gtt tcc  acc aaa cag aag atc  tcg ccc tgg gat ctt  ttt gag ggg        5278
Val Ser  Thr Lys Gln Lys Ile  Ser Pro Trp Asp Leu  Phe Glu Gly            
    1680                 1685                 1690                        

ttg aag  ccg tca gca cca ctc  tct tgg ggc tgg ttt  gga aca gtc        5323
Leu Lys  Pro Ser Ala Pro Leu  Ser Trp Gly Trp Phe  Gly Thr Val            
    1695                 1700                 1705                        

cga gtg  gac cgg cga gtg gct  cga gga gag gag cag  cag cgg ttg        5368
Arg Val  Asp Arg Arg Val Ala  Arg Gly Glu Glu Gln  Gln Arg Leu            
    1710                 1715                 1720                        

ctg ctc  tac cac aca cac ctg  agg ccc cgg ccc cgc  gcc tat tac        5413
Leu Leu  Tyr His Thr His Leu  Arg Pro Arg Pro Arg  Ala Tyr Tyr            
    1725                 1730                 1735                        

ctg gag  cca ctg cca ctg ccc  cca gaa gat gag gag  ccg cct gct        5458
Leu Glu  Pro Leu Pro Leu Pro  Pro Glu Asp Glu Glu  Pro Pro Ala            
    1740                 1745                 1750                        

cct acc  ctg cta gag cct gag  aaa aag gct cca gag  ccc ccc aaa        5503
Pro Thr  Leu Leu Glu Pro Glu  Lys Lys Ala Pro Glu  Pro Pro Lys            
    1755                 1760                 1765                        

act gac  aaa ccg ggg gct gct  cca ccc agt act gag  gaa cgc aag        5548
Thr Asp  Lys Pro Gly Ala Ala  Pro Pro Ser Thr Glu  Glu Arg Lys            
    1770                 1775                 1780                        

aag aag  tcc acc aag ggc aag  aaa cgc agc cag cca  gct acc aag        5593
Lys Lys  Ser Thr Lys Gly Lys  Lys Arg Ser Gln Pro  Ala Thr Lys            
    1785                 1790                 1795                        

aca gag  gac tat gga atg ggc  ccg ggt cgg agc ggc  cct tat ggt        5638
Thr Glu  Asp Tyr Gly Met Gly  Pro Gly Arg Ser Gly  Pro Tyr Gly            
    1800                 1805                 1810                        

gtg aca  gtg cct ccg gac ctc  ctg cac cac cca aac  cct ggt tct        5683
Val Thr  Val Pro Pro Asp Leu  Leu His His Pro Asn  Pro Gly Ser            
    1815                 1820                 1825                        

ata aca  cac ctt aac tac agg  caa ggc tcc ata ggc  ctg tac acc        5728
Ile Thr  His Leu Asn Tyr Arg  Gln Gly Ser Ile Gly  Leu Tyr Thr            
    1830                 1835                 1840                        

cag aac  cag cca cta cct gca  ggt ggc cct cgt gtg  gac cca tac        5773
Gln Asn  Gln Pro Leu Pro Ala  Gly Gly Pro Arg Val  Asp Pro Tyr            
    1845                 1850                 1855                        

cgt cct  gtg cgc tta cca atg  cag aag ctg ccc acc  cga cca act        5818
Arg Pro  Val Arg Leu Pro Met  Gln Lys Leu Pro Thr  Arg Pro Thr            
    1860                 1865                 1870                        

tac cct  gga gtg ctg ccc aca  acc atg act ggc gtc  atg ggt tta        5863
Tyr Pro  Gly Val Leu Pro Thr  Thr Met Thr Gly Val  Met Gly Leu            
    1875                 1880                 1885                        

gaa ccc  tcc tct tat aag acc  tct gtg tac cgg cag  cag caa cct        5908
Glu Pro  Ser Ser Tyr Lys Thr  Ser Val Tyr Arg Gln  Gln Gln Pro            
    1890                 1895                 1900                        

gcg gtg  ccc caa gga cag cgc  ctt cgc caa cag ctc  cag cag agt        5953
Ala Val  Pro Gln Gly Gln Arg  Leu Arg Gln Gln Leu  Gln Gln Ser            
    1905                 1910                 1915                        

cag ggc  atg ttg gga cag tca  tct gtc cat cag atg  act ccc agc        5998
Gln Gly  Met Leu Gly Gln Ser  Ser Val His Gln Met  Thr Pro Ser            
    1920                 1925                 1930                        

tct tcc  tac ggt ttg cag act  tcc cag ggc tat act  cct tat gtt        6043
Ser Ser  Tyr Gly Leu Gln Thr  Ser Gln Gly Tyr Thr  Pro Tyr Val            
    1935                 1940                 1945                        

tct cat  gtg gga ttg cag caa  cac aca ggc cct gca  ggt acc atg        6088
Ser His  Val Gly Leu Gln Gln  His Thr Gly Pro Ala  Gly Thr Met            
    1950                 1955                 1960                        

gtg ccc  ccc agc tac tcc agc  cag cct tac cag agc  acc cac cct        6133
Val Pro  Pro Ser Tyr Ser Ser  Gln Pro Tyr Gln Ser  Thr His Pro            
    1965                 1970                 1975                        

tct acc  aat cct act ctt gta  gat cct acc cgc cac  ctg caa cag        6178
Ser Thr  Asn Pro Thr Leu Val  Asp Pro Thr Arg His  Leu Gln Gln            
    1980                 1985                 1990                        

cgg ccc  agt ggc tat gtg cac  cag cag gcc ccc acc  tat gga cat        6223
Arg Pro  Ser Gly Tyr Val His  Gln Gln Ala Pro Thr  Tyr Gly His            
    1995                 2000                 2005                        

gga ctg  acc tcc act caa agg  ttt tca cac cag aca  ctg cag cag        6268
Gly Leu  Thr Ser Thr Gln Arg  Phe Ser His Gln Thr  Leu Gln Gln            
    2010                 2015                 2020                        

aca ccc  atg ata agt acc atg  act cca atg agt gcc  cag ggc gtc        6313
Thr Pro  Met Ile Ser Thr Met  Thr Pro Met Ser Ala  Gln Gly Val            
    2025                 2030                 2035                        

cag gca  ggc gtc cgt tca aca  gcc atc cta cct gag  cag cag cag        6358
Gln Ala  Gly Val Arg Ser Thr  Ala Ile Leu Pro Glu  Gln Gln Gln            
    2040                 2045                 2050                        

cag cag  caa cag cag caa cag  caa cag cag cag cag  cag caa cag        6403
Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln            
    2055                 2060                 2065                        

caa cag  cag cag cag cag cag  cag tac cac atc cgg  cag cag cag        6448
Gln Gln  Gln Gln Gln Gln Gln  Gln Tyr His Ile Arg  Gln Gln Gln            
    2070                 2075                 2080                        

cag cag  cag atc ctg cgg cag  cag cag caa cag caa  cag cag cag        6493
Gln Gln  Gln Ile Leu Arg Gln  Gln Gln Gln Gln Gln  Gln Gln Gln            
    2085                 2090                 2095                        

cag cag  cag cag caa cag caa  cag cag cag cag caa  cag caa caa        6538
Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln            
    2100                 2105                 2110                        

cag caa  cac cag cag caa cag  cag caa cag gcg gct  cct ccc caa        6583
Gln Gln  His Gln Gln Gln Gln  Gln Gln Gln Ala Ala  Pro Pro Gln            
    2115                 2120                 2125                        

ccc cag  ccc cag tcc cag ccc  cag ttc cag cgc cag  ggg ctt cag        6628
Pro Gln  Pro Gln Ser Gln Pro  Gln Phe Gln Arg Gln  Gly Leu Gln            
    2130                 2135                 2140                        

cag acc  cag cag cag caa cag  aca gca gct ttg gtc  cgg caa ctt        6673
Gln Thr  Gln Gln Gln Gln Gln  Thr Ala Ala Leu Val  Arg Gln Leu            
    2145                 2150                 2155                        

caa caa  cag ctc tct aat acc  cag cca cag ccc agt  acc aac ata        6718
Gln Gln  Gln Leu Ser Asn Thr  Gln Pro Gln Pro Ser  Thr Asn Ile            
    2160                 2165                 2170                        

ttt gga  cgc tac tgagccacct ggaggaactg cttgtgcact ggatgtggcc          6770
Phe Gly  Arg Tyr                                                          
    2175                                                                  

ccaccctttc ctcttaattc ccaatcccat tcctgggcta gcaccagtag tggttggggc     6830

cctcccctca ggctccattt ttaataagtt tttagtattt ttgttaatgt gaggcattga     6890

gctgttgggt tttgtatatt atttatatag agaccccaga gctgttgcac ccaatacaca     6950

gagcttcttt gcaaagggaa aaaaaaaaaa aaaaa                                6985


<210>  2
<211>  2177
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Phe Gly Ile Leu Ser Tyr Glu His Arg Pro Leu Lys Arg 
1               5                   10                  15      


Pro Arg Leu Gly Pro Pro Asp Val Tyr Pro Gln Asp Pro Lys Gln Lys 
            20                  25                  30          


Glu Asp Glu Leu Thr Ala Leu Asn Val Lys Gln Gly Phe Asn Asn Gln 
        35                  40                  45              


Pro Ala Val Ser Gly Asp Glu His Gly Ser Ala Lys Asn Val Ser Phe 
    50                  55                  60                  


Asn Pro Ala Lys Ile Ser Ser Asn Phe Ser Ser Ile Ile Ala Glu Lys 
65                  70                  75                  80  


Leu Arg Cys Asn Thr Leu Pro Asp Thr Gly Arg Arg Lys Pro Gln Val 
                85                  90                  95      


Asn Gln Lys Asp Asn Phe Trp Leu Val Thr Ala Arg Ser Gln Ser Ala 
            100                 105                 110         


Ile Asn Thr Trp Phe Thr Asp Leu Ala Gly Thr Lys Pro Leu Thr Gln 
        115                 120                 125             


Leu Ala Lys Lys Val Pro Ile Phe Ser Lys Lys Glu Glu Val Phe Gly 
    130                 135                 140                 


Tyr Leu Ala Lys Tyr Thr Val Pro Val Met Arg Ala Ala Trp Leu Ile 
145                 150                 155                 160 


Lys Met Thr Cys Ala Tyr Tyr Ala Ala Ile Ser Glu Thr Lys Val Lys 
                165                 170                 175     


Lys Arg His Val Asp Pro Phe Met Glu Trp Thr Gln Ile Ile Thr Lys 
            180                 185                 190         


Tyr Leu Trp Glu Gln Leu Gln Lys Met Ala Glu Tyr Tyr Arg Pro Gly 
        195                 200                 205             


Pro Ala Gly Ser Gly Gly Cys Gly Ser Thr Ile Gly Pro Leu Pro His 
    210                 215                 220                 


Asp Val Glu Val Ala Ile Arg Gln Trp Asp Tyr Thr Glu Lys Leu Ala 
225                 230                 235                 240 


Met Phe Met Phe Gln Asp Gly Met Leu Asp Arg His Glu Phe Leu Thr 
                245                 250                 255     


Trp Val Leu Glu Cys Phe Glu Lys Ile Arg Pro Gly Glu Asp Glu Leu 
            260                 265                 270         


Leu Lys Leu Leu Leu Pro Leu Leu Leu Arg Tyr Ser Gly Glu Phe Val 
        275                 280                 285             


Gln Ser Ala Tyr Leu Ser Arg Arg Leu Ala Tyr Phe Cys Thr Arg Arg 
    290                 295                 300                 


Leu Ala Leu Gln Leu Asp Gly Val Ser Ser His Ser Ser His Val Ile 
305                 310                 315                 320 


Ser Ala Gln Ser Thr Ser Thr Leu Pro Thr Thr Pro Ala Pro Gln Pro 
                325                 330                 335     


Pro Thr Ser Ser Thr Pro Ser Thr Pro Phe Ser Asp Leu Leu Met Cys 
            340                 345                 350         


Pro Gln His Arg Pro Leu Val Phe Gly Leu Ser Cys Ile Leu Gln Thr 
        355                 360                 365             


Ile Leu Leu Cys Cys Pro Ser Ala Leu Val Trp His Tyr Ser Leu Thr 
    370                 375                 380                 


Asp Ser Arg Ile Lys Thr Gly Ser Pro Leu Asp His Leu Pro Ile Ala 
385                 390                 395                 400 


Pro Ser Asn Leu Pro Met Pro Glu Gly Asn Ser Ala Phe Thr Gln Gln 
                405                 410                 415     


Val Arg Ala Lys Leu Arg Glu Ile Glu Gln Gln Ile Lys Glu Arg Gly 
            420                 425                 430         


Gln Ala Val Glu Val Arg Trp Ser Phe Asp Lys Cys Gln Glu Ala Thr 
        435                 440                 445             


Ala Gly Phe Thr Ile Gly Arg Val Leu His Thr Leu Glu Val Leu Asp 
    450                 455                 460                 


Ser His Ser Phe Glu Arg Ser Asp Phe Ser Asn Ser Leu Asp Ser Leu 
465                 470                 475                 480 


Cys Asn Arg Ile Phe Gly Leu Gly Pro Ser Lys Asp Gly His Glu Ile 
                485                 490                 495     


Ser Ser Asp Asp Asp Ala Val Val Ser Leu Leu Cys Glu Trp Ala Val 
            500                 505                 510         


Ser Cys Lys Arg Ser Gly Arg His Arg Ala Met Val Val Ala Lys Leu 
        515                 520                 525             


Leu Glu Lys Arg Gln Ala Glu Ile Glu Ala Glu Arg Cys Gly Glu Ser 
    530                 535                 540                 


Glu Ala Ala Asp Glu Lys Gly Ser Ile Ala Ser Gly Ser Leu Ser Ala 
545                 550                 555                 560 


Pro Ser Ala Pro Ile Phe Gln Asp Val Leu Leu Gln Phe Leu Asp Thr 
                565                 570                 575     


Gln Ala Pro Met Leu Thr Asp Pro Arg Ser Glu Ser Glu Arg Val Glu 
            580                 585                 590         


Phe Phe Asn Leu Val Leu Leu Phe Cys Glu Leu Ile Arg His Asp Val 
        595                 600                 605             


Phe Ser His Asn Met Tyr Thr Cys Thr Leu Ile Ser Arg Gly Asp Leu 
    610                 615                 620                 


Ala Phe Gly Ala Pro Gly Pro Arg Pro Pro Ser Pro Phe Asp Asp Pro 
625                 630                 635                 640 


Ala Asp Asp Pro Glu His Lys Glu Ala Glu Gly Ser Ser Ser Ser Lys 
                645                 650                 655     


Leu Glu Asp Pro Gly Leu Ser Glu Ser Met Asp Ile Asp Pro Ser Ser 
            660                 665                 670         


Ser Val Leu Phe Glu Asp Met Glu Lys Pro Asp Phe Ser Leu Phe Ser 
        675                 680                 685             


Pro Thr Met Pro Cys Glu Gly Lys Gly Ser Pro Ser Pro Glu Lys Pro 
    690                 695                 700                 


Asp Val Glu Lys Glu Val Lys Pro Pro Pro Lys Glu Lys Ile Glu Gly 
705                 710                 715                 720 


Thr Leu Gly Val Leu Tyr Asp Gln Pro Arg His Val Gln Tyr Ala Thr 
                725                 730                 735     


His Phe Pro Ile Pro Gln Glu Glu Ser Cys Ser His Glu Cys Asn Gln 
            740                 745                 750         


Arg Leu Val Val Leu Phe Gly Val Gly Lys Gln Arg Asp Asp Ala Arg 
        755                 760                 765             


His Ala Ile Lys Lys Ile Thr Lys Asp Ile Leu Lys Val Leu Asn Arg 
    770                 775                 780                 


Lys Gly Thr Ala Glu Thr Asp Gln Leu Ala Pro Ile Val Pro Leu Asn 
785                 790                 795                 800 


Pro Gly Asp Leu Thr Phe Leu Gly Gly Glu Asp Gly Gln Lys Arg Arg 
                805                 810                 815     


Arg Asn Arg Pro Glu Ala Phe Pro Thr Ala Glu Asp Ile Phe Ala Lys 
            820                 825                 830         


Phe Gln His Leu Ser His Tyr Asp Gln His Gln Val Thr Ala Gln Val 
        835                 840                 845             


Ser Arg Asn Val Leu Glu Gln Ile Thr Ser Phe Ala Leu Gly Met Ser 
    850                 855                 860                 


Tyr His Leu Pro Leu Val Gln His Val Gln Phe Ile Phe Asp Leu Met 
865                 870                 875                 880 


Glu Tyr Ser Leu Ser Ile Ser Gly Leu Ile Asp Phe Ala Ile Gln Leu 
                885                 890                 895     


Leu Asn Glu Leu Ser Val Val Glu Ala Glu Leu Leu Leu Lys Ser Ser 
            900                 905                 910         


Asp Leu Val Gly Ser Tyr Thr Thr Ser Leu Cys Leu Cys Ile Val Ala 
        915                 920                 925             


Val Leu Arg His Tyr His Ala Cys Leu Ile Leu Asn Gln Asp Gln Met 
    930                 935                 940                 


Ala Gln Val Phe Glu Gly Leu Cys Gly Val Val Lys His Gly Met Asn 
945                 950                 955                 960 


Arg Ser Asp Gly Ser Ser Ala Glu Arg Cys Ile Leu Ala Tyr Leu Tyr 
                965                 970                 975     


Asp Leu Tyr Thr Ser Cys Ser His Leu Lys Asn Lys Phe Gly Glu Leu 
            980                 985                 990         


Phe Ser Asp Phe Cys Ser Lys Val  Lys Asn Thr Ile Tyr  Cys Asn Val 
        995                 1000                 1005             


Glu Pro  Ser Glu Ser Asn Met  Arg Trp Ala Pro Glu  Phe Met Ile 
    1010                 1015                 1020             


Asp Thr  Leu Glu Asn Pro Ala  Ala His Thr Phe Thr  Tyr Thr Gly 
    1025                 1030                 1035             


Leu Gly  Lys Ser Leu Ser Glu  Asn Pro Ala Asn Arg  Tyr Ser Phe 
    1040                 1045                 1050             


Val Cys  Asn Ala Leu Met His  Val Cys Val Gly His  His Asp Pro 
    1055                 1060                 1065             


Asp Arg  Val Asn Asp Ile Ala  Ile Leu Cys Ala Glu  Leu Thr Gly 
    1070                 1075                 1080             


Tyr Cys  Lys Ser Leu Ser Ala  Glu Trp Leu Gly Val  Leu Lys Ala 
    1085                 1090                 1095             


Leu Cys  Cys Ser Ser Asn Asn  Gly Thr Cys Gly Phe  Asn Asp Leu 
    1100                 1105                 1110             


Leu Cys  Asn Val Asp Val Ser  Asp Leu Ser Phe His  Asp Ser Leu 
    1115                 1120                 1125             


Ala Thr  Phe Val Ala Ile Leu  Ile Ala Arg Gln Cys  Leu Leu Leu 
    1130                 1135                 1140             


Glu Asp  Leu Ile Arg Cys Ala  Ala Ile Pro Ser Leu  Leu Asn Ala 
    1145                 1150                 1155             


Ala Cys  Ser Glu Gln Asp Ser  Glu Pro Gly Ala Arg  Leu Thr Cys 
    1160                 1165                 1170             


Arg Ile  Leu Leu His Leu Phe  Lys Thr Pro Gln Leu  Asn Pro Cys 
    1175                 1180                 1185             


Gln Ser  Asp Gly Asn Lys Pro  Thr Val Gly Ile Arg  Ser Ser Cys 
    1190                 1195                 1200             


Asp Arg  His Leu Leu Ala Ala  Ser Gln Asn Arg Ile  Val Asp Gly 
    1205                 1210                 1215             


Ala Val  Phe Ala Val Leu Lys  Ala Val Phe Val Leu  Gly Asp Ala 
    1220                 1225                 1230             


Glu Leu  Lys Gly Ser Gly Phe  Thr Val Thr Gly Gly  Thr Glu Glu 
    1235                 1240                 1245             


Leu Pro  Glu Glu Glu Gly Gly  Gly Gly Ser Gly Gly  Arg Arg Gln 
    1250                 1255                 1260             


Gly Gly  Arg Asn Ile Ser Val  Glu Thr Ala Ser Leu  Asp Val Tyr 
    1265                 1270                 1275             


Ala Lys  Tyr Val Leu Arg Ser  Ile Cys Gln Gln Glu  Trp Val Gly 
    1280                 1285                 1290             


Glu Arg  Cys Leu Lys Ser Leu  Cys Glu Asp Ser Asn  Asp Leu Gln 
    1295                 1300                 1305             


Asp Pro  Val Leu Ser Ser Ala  Gln Ala Gln Arg Leu  Met Gln Leu 
    1310                 1315                 1320             


Ile Cys  Tyr Pro His Arg Leu  Leu Asp Asn Glu Asp  Gly Glu Asn 
    1325                 1330                 1335             


Pro Gln  Arg Gln Arg Ile Lys  Arg Ile Leu Gln Asn  Leu Asp Gln 
    1340                 1345                 1350             


Trp Thr  Met Arg Gln Ser Ser  Leu Glu Leu Gln Leu  Met Ile Lys 
    1355                 1360                 1365             


Gln Thr  Pro Asn Asn Glu Met  Asn Ser Leu Leu Glu  Asn Ile Ala 
    1370                 1375                 1380             


Lys Ala  Thr Ile Glu Val Phe  Gln Gln Ser Ala Glu  Thr Gly Ser 
    1385                 1390                 1395             


Ser Ser  Gly Ser Thr Ala Ser  Asn Met Pro Ser Ser  Ser Lys Thr 
    1400                 1405                 1410             


Lys Pro  Val Leu Ser Ser Leu  Glu Arg Ser Gly Val  Trp Leu Val 
    1415                 1420                 1425             


Ala Pro  Leu Ile Ala Lys Leu  Pro Thr Ser Val Gln  Gly His Val 
    1430                 1435                 1440             


Leu Lys  Ala Ala Gly Glu Glu  Leu Glu Lys Gly Gln  His Leu Gly 
    1445                 1450                 1455             


Ser Ser  Ser Arg Lys Glu Arg  Asp Arg Gln Lys Gln  Lys Ser Met 
    1460                 1465                 1470             


Ser Leu  Leu Ser Gln Gln Pro  Phe Leu Ser Leu Val  Leu Thr Cys 
    1475                 1480                 1485             


Leu Lys  Gly Gln Asp Glu Gln  Arg Glu Gly Leu Leu  Thr Ser Leu 
    1490                 1495                 1500             


Tyr Ser  Gln Val His Gln Ile  Val Asn Asn Trp Arg  Asp Asp Gln 
    1505                 1510                 1515             


Tyr Leu  Asp Asp Cys Lys Pro  Lys Gln Leu Met His  Glu Ala Leu 
    1520                 1525                 1530             


Lys Leu  Arg Leu Asn Leu Val  Gly Gly Met Phe Asp  Thr Val Gln 
    1535                 1540                 1545             


Arg Ser  Thr Gln Gln Thr Thr  Glu Trp Ala Met Leu  Leu Leu Glu 
    1550                 1555                 1560             


Ile Ile  Ile Ser Gly Thr Val  Asp Met Gln Ser Asn  Asn Glu Leu 
    1565                 1570                 1575             


Phe Thr  Thr Val Leu Asp Met  Leu Ser Val Leu Ile  Asn Gly Thr 
    1580                 1585                 1590             


Leu Ala  Ala Asp Met Ser Ser  Ile Ser Gln Gly Ser  Met Glu Glu 
    1595                 1600                 1605             


Asn Lys  Arg Ala Tyr Met Asn  Leu Ala Lys Lys Leu  Gln Lys Glu 
    1610                 1615                 1620             


Leu Gly  Glu Arg Gln Ser Asp  Ser Leu Glu Lys Val  Arg Gln Leu 
    1625                 1630                 1635             


Leu Pro  Leu Pro Lys Gln Thr  Arg Asp Val Ile Thr  Cys Glu Pro 
    1640                 1645                 1650             


Gln Gly  Ser Leu Ile Asp Thr  Lys Gly Asn Lys Ile  Ala Gly Phe 
    1655                 1660                 1665             


Asp Ser  Ile Phe Lys Lys Glu  Gly Leu Gln Val Ser  Thr Lys Gln 
    1670                 1675                 1680             


Lys Ile  Ser Pro Trp Asp Leu  Phe Glu Gly Leu Lys  Pro Ser Ala 
    1685                 1690                 1695             


Pro Leu  Ser Trp Gly Trp Phe  Gly Thr Val Arg Val  Asp Arg Arg 
    1700                 1705                 1710             


Val Ala  Arg Gly Glu Glu Gln  Gln Arg Leu Leu Leu  Tyr His Thr 
    1715                 1720                 1725             


His Leu  Arg Pro Arg Pro Arg  Ala Tyr Tyr Leu Glu  Pro Leu Pro 
    1730                 1735                 1740             


Leu Pro  Pro Glu Asp Glu Glu  Pro Pro Ala Pro Thr  Leu Leu Glu 
    1745                 1750                 1755             


Pro Glu  Lys Lys Ala Pro Glu  Pro Pro Lys Thr Asp  Lys Pro Gly 
    1760                 1765                 1770             


Ala Ala  Pro Pro Ser Thr Glu  Glu Arg Lys Lys Lys  Ser Thr Lys 
    1775                 1780                 1785             


Gly Lys  Lys Arg Ser Gln Pro  Ala Thr Lys Thr Glu  Asp Tyr Gly 
    1790                 1795                 1800             


Met Gly  Pro Gly Arg Ser Gly  Pro Tyr Gly Val Thr  Val Pro Pro 
    1805                 1810                 1815             


Asp Leu  Leu His His Pro Asn  Pro Gly Ser Ile Thr  His Leu Asn 
    1820                 1825                 1830             


Tyr Arg  Gln Gly Ser Ile Gly  Leu Tyr Thr Gln Asn  Gln Pro Leu 
    1835                 1840                 1845             


Pro Ala  Gly Gly Pro Arg Val  Asp Pro Tyr Arg Pro  Val Arg Leu 
    1850                 1855                 1860             


Pro Met  Gln Lys Leu Pro Thr  Arg Pro Thr Tyr Pro  Gly Val Leu 
    1865                 1870                 1875             


Pro Thr  Thr Met Thr Gly Val  Met Gly Leu Glu Pro  Ser Ser Tyr 
    1880                 1885                 1890             


Lys Thr  Ser Val Tyr Arg Gln  Gln Gln Pro Ala Val  Pro Gln Gly 
    1895                 1900                 1905             


Gln Arg  Leu Arg Gln Gln Leu  Gln Gln Ser Gln Gly  Met Leu Gly 
    1910                 1915                 1920             


Gln Ser  Ser Val His Gln Met  Thr Pro Ser Ser Ser  Tyr Gly Leu 
    1925                 1930                 1935             


Gln Thr  Ser Gln Gly Tyr Thr  Pro Tyr Val Ser His  Val Gly Leu 
    1940                 1945                 1950             


Gln Gln  His Thr Gly Pro Ala  Gly Thr Met Val Pro  Pro Ser Tyr 
    1955                 1960                 1965             


Ser Ser  Gln Pro Tyr Gln Ser  Thr His Pro Ser Thr  Asn Pro Thr 
    1970                 1975                 1980             


Leu Val  Asp Pro Thr Arg His  Leu Gln Gln Arg Pro  Ser Gly Tyr 
    1985                 1990                 1995             


Val His  Gln Gln Ala Pro Thr  Tyr Gly His Gly Leu  Thr Ser Thr 
    2000                 2005                 2010             


Gln Arg  Phe Ser His Gln Thr  Leu Gln Gln Thr Pro  Met Ile Ser 
    2015                 2020                 2025             


Thr Met  Thr Pro Met Ser Ala  Gln Gly Val Gln Ala  Gly Val Arg 
    2030                 2035                 2040             


Ser Thr  Ala Ile Leu Pro Glu  Gln Gln Gln Gln Gln  Gln Gln Gln 
    2045                 2050                 2055             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    2060                 2065                 2070             


Gln Gln  Gln Tyr His Ile Arg  Gln Gln Gln Gln Gln  Gln Ile Leu 
    2075                 2080                 2085             


Arg Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    2090                 2095                 2100             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  His Gln Gln 
    2105                 2110                 2115             


Gln Gln  Gln Gln Gln Ala Ala  Pro Pro Gln Pro Gln  Pro Gln Ser 
    2120                 2125                 2130             


Gln Pro  Gln Phe Gln Arg Gln  Gly Leu Gln Gln Thr  Gln Gln Gln 
    2135                 2140                 2145             


Gln Gln  Thr Ala Ala Leu Val  Arg Gln Leu Gln Gln  Gln Leu Ser 
    2150                 2155                 2160             


Asn Thr  Gln Pro Gln Pro Ser  Thr Asn Ile Phe Gly  Arg Tyr 
    2165                 2170                 2175         


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward 1 - primer used to amplify the desired PCR fragment of 
       the genomic template DNA

<400>  3
ccccttcccc taaggaaaaa                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse 1 -  primer used to amplify the desired PCR fragment of 
       the genomic template DNA and for the amplification of the target 
       cDNA-fragment

<400>  4
atgctcatcc ccagagacag                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward 2 - primer used for amplification of the target 
       cDNA-fragment

<400>  5
cttcgggatc ttgagctacg                                                   20


<210>  6
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide used to amplify the desired PCR fragment of the 
       canine template DNA as well as the canine target cDNA-fragment

<400>  6
gatgaactga cagccttgaa tg                                                22


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide used to amplify the desired PCR fragment of the 
       canine template DNA as well as the canine target cDNA-fragment

<400>  7
cttggcagga ttgaagttga c                                                 21


