                         SEQUENCE LISTING

<110>  Janssen Biotech, Inc.
       
 
<120>  Fibronectin Type III Repeat Based Protein Scaffolds With 
       Alternative Binding Surfaces

<130>  CEN5315WOPCT

<140>  To Be Assigned
<141>  2012-09-27

<150>  61/539670
<151>  2011-09-27

<160>  101   

<170>  PatentIn version 3.5

<210>  1
<211>  87
<212>  PRT
<213>  homo sapiens

<400>  1

Ser Pro Pro Lys Asp Leu Val Val Thr Glu Val Thr Glu Glu Thr Val 
1               5                   10                  15      


Asn Leu Ala Trp Asp Asn Glu Met Arg Val Thr Glu Tyr Leu Val Val 
            20                  25                  30          


Tyr Thr Pro Thr His Glu Gly Gly Leu Glu Met Gln Phe Arg Val Pro 
        35                  40                  45              


Gly Asp Gln Thr Ser Thr Ile Ile Gln Glu Leu Glu Pro Gly Val Glu 
    50                  55                  60                  


Tyr Phe Ile Arg Val Phe Ala Ile Leu Glu Asn Lys Lys Ser Ile Pro 
65                  70                  75                  80  


Val Ser Ala Arg Val Ala Thr 
                85          


<210>  2
<211>  95
<212>  PRT
<213>  homo sapiens

<400>  2

Thr Tyr Leu Pro Ala Pro Glu Gly Leu Lys Phe Lys Ser Ile Lys Glu 
1               5                   10                  15      


Thr Ser Val Glu Val Glu Trp Asp Pro Leu Asp Ile Ala Phe Glu Thr 
            20                  25                  30          


Trp Glu Ile Ile Phe Arg Asn Met Asn Lys Glu Asp Glu Gly Glu Ile 
        35                  40                  45              


Thr Lys Ser Leu Arg Arg Pro Glu Thr Ser Tyr Arg Gln Thr Gly Leu 
    50                  55                  60                  


Ala Pro Gly Gln Glu Tyr Glu Ile Ser Leu His Ile Val Lys Asn Asn 
65                  70                  75                  80  


Thr Arg Gly Pro Gly Leu Lys Arg Val Thr Thr Thr Arg Leu Asp 
                85                  90                  95  


<210>  3
<211>  88
<212>  PRT
<213>  homo sapiens

<400>  3

Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr Thr Ala 
1               5                   10                  15      


Leu Ile Thr Trp Phe Lys Pro Leu Ala Glu Ile Asp Gly Ile Glu Leu 
            20                  25                  30          


Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr Ile Asp Leu 
        35                  40                  45              


Thr Glu Asp Glu Asn Gln Tyr Ser Ile Gly Asn Leu Lys Pro Asp Thr 
    50                  55                  60                  


Glu Tyr Glu Val Ser Leu Ile Ser Arg Arg Gly Asp Met Ser Ser Asn 
65                  70                  75                  80  


Pro Ala Lys Glu Thr Phe Thr Thr 
                85              


<210>  4
<211>  100
<212>  PRT
<213>  homo sapiens

<400>  4

Thr Gly Leu Asp Ala Pro Arg Asn Leu Arg Arg Val Ser Gln Thr Asp 
1               5                   10                  15      


Asn Ser Ile Thr Leu Glu Trp Arg Asn Gly Lys Ala Ala Ile Asp Ser 
            20                  25                  30          


Tyr Arg Ile Lys Tyr Ala Pro Ile Ser Gly Gly Asp His Ala Glu Val 
        35                  40                  45              


Asp Val Pro Lys Ser Gln Gln Ala Thr Thr Lys Thr Thr Leu Thr Gly 
    50                  55                  60                  


Leu Arg Pro Gly Thr Glu Tyr Gly Ile Gly Val Ser Ala Val Lys Glu 
65                  70                  75                  80  


Asp Lys Glu Ser Asn Pro Ala Thr Ile Asn Ala Ala Thr Glu Leu Asp 
                85                  90                  95      


Thr Pro Lys Asp 
            100 


<210>  5
<211>  88
<212>  PRT
<213>  homo sapiens

<400>  5

Asp Thr Pro Lys Asp Leu Gln Val Ser Glu Thr Ala Glu Thr Ser Leu 
1               5                   10                  15      


Thr Leu Leu Trp Lys Thr Pro Leu Ala Lys Phe Asp Arg Tyr Arg Leu 
            20                  25                  30          


Asn Tyr Ser Leu Pro Thr Gly Gln Trp Val Gly Val Gln Leu Pro Arg 
        35                  40                  45              


Asn Thr Thr Ser Tyr Val Leu Arg Gly Leu Glu Pro Gly Gln Glu Tyr 
    50                  55                  60                  


Asn Val Leu Leu Thr Ala Glu Lys Gly Arg His Lys Ser Lys Pro Ala 
65                  70                  75                  80  


Lys Ser Lys Pro Ala Arg Val Lys 
                85              


<210>  6
<211>  92
<212>  PRT
<213>  homo sapiens

<400>  6

Gln Ala Pro Glu Leu Glu Asn Leu Thr Val Thr Glu Val Gly Trp Asp 
1               5                   10                  15      


Gly Leu Arg Leu Asn Trp Thr Ala Ala Asp Gln Ala Tyr Glu His Phe 
            20                  25                  30          


Ile Ile Gln Val Gln Glu Ala Asn Lys Val Glu Ala Ala Arg Asn Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Leu Arg Ala Val Asp Ile Pro Gly Leu Lys Ala 
    50                  55                  60                  


Ala Thr Pro Tyr Thr Val Ser Ile Tyr Gly Val Ile Gln Gly Tyr Arg 
65                  70                  75                  80  


Thr Pro Val Leu Ser Ala Glu Ala Ser Thr Gly Glu 
                85                  90          


<210>  7
<211>  91
<212>  PRT
<213>  homo sapiens

<400>  7

Glu Thr Pro Asn Leu Gly Glu Val Val Val Ala Glu Val Gly Trp Asp 
1               5                   10                  15      


Ala Leu Lys Leu Asn Trp Thr Ala Pro Glu Gly Ala Tyr Glu Tyr Phe 
            20                  25                  30          


Phe Ile Gln Val Gln Glu Ala Asp Thr Val Glu Ala Ala Gln Asn Leu 
        35                  40                  45              


Thr Val Pro Gly Gly Leu Arg Ser Thr Asp Leu Pro Gly Leu Lys Ala 
    50                  55                  60                  


Ala Thr His Tyr Thr Ile Thr Ile Arg Gly Val Thr Gln Asp Phe Ser 
65                  70                  75                  80  


Thr Thr Pro Leu Ser Val Glu Val Leu Thr Glu 
                85                  90      


<210>  8
<211>  91
<212>  PRT
<213>  homo sapiens

<400>  8

Glu Val Pro Asp Met Gly Asn Leu Thr Val Thr Glu Val Ser Trp Asp 
1               5                   10                  15      


Ala Leu Arg Leu Asn Trp Thr Thr Pro Asp Gly Thr Tyr Asp Gln Phe 
            20                  25                  30          


Thr Ile Gln Val Gln Glu Ala Asp Gln Val Glu Glu Ala His Asn Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Leu Arg Ser Met Glu Ile Pro Gly Leu Arg Ala 
    50                  55                  60                  


Gly Thr Pro Tyr Thr Val Thr Leu His Gly Glu Val Arg Gly His Ser 
65                  70                  75                  80  


Thr Arg Pro Leu Ala Val Glu Val Val Thr Glu 
                85                  90      


<210>  9
<211>  95
<212>  PRT
<213>  homo sapiens

<400>  9

Asp Leu Pro Gln Leu Gly Asp Leu Ala Val Ser Glu Val Gly Trp Asp 
1               5                   10                  15      


Gly Leu Arg Leu Asn Trp Thr Ala Ala Asp Asn Ala Tyr Glu His Phe 
            20                  25                  30          


Val Ile Gln Val Gln Glu Val Asn Lys Val Glu Ala Ala Gln Asn Leu 
        35                  40                  45              


Thr Leu Pro Gly Ser Leu Arg Ala Val Asp Ile Pro Gly Leu Glu Ala 
    50                  55                  60                  


Ala Thr Pro Tyr Arg Val Ser Ile Tyr Gly Val Ile Arg Gly Tyr Arg 
65                  70                  75                  80  


Thr Pro Val Leu Ser Ala Glu Ala Ser Thr Ala Lys Glu Pro Glu 
                85                  90                  95  


<210>  10
<211>  91
<212>  PRT
<213>  homo sapiens

<400>  10

Lys Glu Pro Glu Ile Gly Asn Leu Asn Val Ser Asp Ile Thr Pro Glu 
1               5                   10                  15      


Ser Phe Asn Leu Ser Trp Met Ala Thr Asp Gly Ile Phe Glu Thr Phe 
            20                  25                  30          


Thr Ile Glu Ile Ile Asp Ser Asn Arg Leu Leu Glu Thr Val Glu Tyr 
        35                  40                  45              


Asn Ile Ser Gly Ala Glu Arg Thr Ala His Ile Ser Gly Leu Pro Pro 
    50                  55                  60                  


Ser Thr Asp Phe Ile Val Tyr Leu Ser Gly Leu Ala Pro Ser Ile Arg 
65                  70                  75                  80  


Thr Lys Thr Ile Ser Ala Thr Ala Thr Thr Glu 
                85                  90      


<210>  11
<211>  91
<212>  PRT
<213>  homo sapiens

<400>  11

Ala Leu Pro Leu Leu Glu Asn Leu Thr Ile Ser Asp Ile Asn Pro Tyr 
1               5                   10                  15      


Gly Phe Thr Val Ser Trp Met Ala Ser Glu Asn Ala Phe Asp Ser Phe 
            20                  25                  30          


Leu Val Thr Val Val Asp Ser Gly Lys Leu Leu Asp Pro Gln Glu Phe 
        35                  40                  45              


Thr Leu Ser Gly Thr Gln Arg Lys Leu Glu Leu Arg Gly Leu Ile Thr 
    50                  55                  60                  


Gly Ile Gly Tyr Glu Val Met Val Ser Gly Phe Thr Gln Gly His Gln 
65                  70                  75                  80  


Thr Lys Pro Leu Arg Ala Glu Ile Val Thr Glu 
                85                  90      


<210>  12
<211>  92
<212>  PRT
<213>  homosapiens

<400>  12

Ala Glu Pro Glu Val Asp Asn Leu Leu Val Ser Asp Ala Thr Pro Asp 
1               5                   10                  15      


Gly Phe Arg Leu Ser Trp Thr Ala Asp Glu Gly Val Phe Asp Asn Phe 
            20                  25                  30          


Val Leu Lys Ile Arg Asp Thr Lys Lys Gln Ser Glu Pro Leu Glu Ile 
        35                  40                  45              


Thr Leu Leu Ala Pro Glu Arg Thr Arg Asp Leu Thr Gly Leu Arg Glu 
    50                  55                  60                  


Ala Thr Glu Tyr Glu Ile Glu Leu Tyr Gly Ile Ser Lys Gly Arg Arg 
65                  70                  75                  80  


Ser Gln Thr Val Ser Ala Ile Ala Thr Thr Ala Met 
                85                  90          


<210>  13
<211>  89
<212>  PRT
<213>  homo sapiens

<400>  13

Gly Ser Pro Lys Glu Val Ile Phe Ser Asp Ile Thr Glu Asn Ser Ala 
1               5                   10                  15      


Thr Val Ser Trp Arg Ala Pro Thr Ala Gln Val Glu Ser Phe Arg Ile 
            20                  25                  30          


Thr Tyr Val Pro Ile Thr Gly Gly Thr Pro Ser Met Val Thr Val Asp 
        35                  40                  45              


Gly Thr Lys Thr Gln Thr Arg Leu Val Lys Leu Ile Pro Gly Val Glu 
    50                  55                  60                  


Tyr Leu Val Ser Ile Ile Ala Met Lys Gly Phe Glu Glu Ser Glu Pro 
65                  70                  75                  80  


Val Ser Gly Ser Phe Thr Thr Ala Leu 
                85                  


<210>  14
<211>  88
<212>  PRT
<213>  homo sapiens

<400>  14

Asp Gly Pro Ser Gly Leu Val Thr Ala Asn Ile Thr Asp Ser Glu Ala 
1               5                   10                  15      


Leu Ala Arg Trp Gln Pro Ala Ile Ala Thr Val Asp Ser Tyr Val Ile 
            20                  25                  30          


Ser Tyr Thr Gly Glu Lys Val Pro Glu Ile Thr Arg Thr Val Ser Gly 
        35                  40                  45              


Asn Thr Val Glu Tyr Ala Leu Thr Asp Leu Glu Pro Ala Thr Glu Tyr 
    50                  55                  60                  


Thr Leu Arg Ile Phe Ala Glu Lys Gly Pro Gln Lys Ser Ser Thr Ile 
65                  70                  75                  80  


Thr Ala Lys Phe Thr Thr Asp Leu 
                85              


<210>  15
<211>  89
<212>  PRT
<213>  homosapiens

<400>  15

Asp Ser Pro Arg Asp Leu Thr Ala Thr Glu Val Gln Ser Glu Thr Ala 
1               5                   10                  15      


Leu Leu Thr Trp Arg Pro Pro Arg Ala Ser Val Thr Gly Tyr Leu Leu 
            20                  25                  30          


Val Tyr Glu Ser Val Asp Gly Thr Val Lys Glu Val Ile Val Gly Pro 
        35                  40                  45              


Asp Thr Thr Ser Tyr Ser Leu Ala Asp Leu Ser Pro Ser Thr His Tyr 
    50                  55                  60                  


Thr Ala Lys Ile Gln Ala Leu Asn Gly Pro Leu Arg Ser Asn Met Ile 
65                  70                  75                  80  


Gln Thr Ile Phe Thr Thr Ile Gly Leu 
                85                  


<210>  16
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus FN3 sequence based on tenascin C FN3 domains

<400>  16

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 
1               5                   10                  15      


Leu Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Asn Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Glu Phe Thr Thr 
                85                  


<210>  17
<211>  89
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Consensus FN3 sequence based on tenascin C FN3 domains with 
       additional mutations improving stability

<400>  17

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 
1               5                   10                  15      


Leu Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Glu Phe Thr Thr 
                85                  


<210>  18
<211>  89
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Consensus FN3 sequence based on tenascin C FN3 domains with 
       additional mutations improving stability

<400>  18

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Pro Asp Ser 
1               5                   10                  15      


Leu Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Asn Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Glu Phe Thr Thr 
                85                  


<210>  19
<211>  89
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Consensus FN3 sequence based on tenascin C FN3 domains with 
       additional mutations improving stability

<400>  19

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Asn Val Thr Glu Asp Ser 
1               5                   10                  15      


Leu Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Asn Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Glu Phe Thr Thr 
                85                  


<210>  20
<211>  89
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Consensus FN3 sequence based on tenascin C FN3 domains with 
       additional mutations improving stability

<400>  20

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 
1               5                   10                  15      


Leu Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Pro Ser Glu Lys Val Gly Glu Ala Ile Asn Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Glu Phe Thr Thr 
                85                  


<210>  21
<211>  89
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Consensus FN3 sequence based on tenascin C FN3 domains with 
       additional mutations improving stability

<400>  21

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 
1               5                   10                  15      


Leu Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Asn Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Tyr Val Lys Gly Gly His Arg Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Glu Phe Thr Thr 
                85                  


<210>  22
<211>  89
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Consensus FN3 sequence based on tenascin C FN3 domains with 
       additional mutations improving stability

<400>  22

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 
1               5                   10                  15      


Leu Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Asn Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  23
<211>  89
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Consensus FN3 sequence based on tenascin C FN3 domains with 
       additional mutations improving stability

<400>  23

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 
1               5                   10                  15      


Leu Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  24
<211>  89
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Consensus FN3 sequence based on tenascin C FN3 domains with 
       additional mutations improving stability

<400>  24

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Pro Asp Ser 
1               5                   10                  15      


Leu Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  25
<211>  89
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Consensus FN3 sequence based on tenascin C FN3 domains with 
       additional mutations improving stability

<400>  25

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  26
<211>  89
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Consensus FN3 sequence based on tenascin C FN3 domains with 
       additional mutations improving stability

<400>  26

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Asn Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Glu Phe Thr Thr 
                85                  


<210>  27
<211>  89
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Consensus FN3 sequence based on tenascin C FN3 domains with 
       additional mutations improving stability

<400>  27

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  28
<211>  89
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TCL14 library based on tencon27 scaffold with randomized 
       C-CD-F-FG surface


<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (38)..(41)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (78)..(79)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (81)..(81)
<223>  Xaa can be any naturally occurring amino acid

<400>  28

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Xaa 
            20                  25                  30          


Ile Xaa Tyr Xaa Glu Xaa Xaa Xaa Xaa Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Xaa Val Xaa Ile Xaa Gly Val Lys Gly Gly Xaa Xaa Ser 
65                  70                  75                  80  


Xaa Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  29
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Tencon27 scaffold A strand sequence

<400>  29

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
1               5                   10          


<210>  30
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Tencon27 scaffold AB loop

<400>  30

Thr Glu Asp Ser 
1               


<210>  31
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Tencon27 scaffold B strand

<400>  31

Ala Arg Leu Ser Trp 
1               5   


<210>  32
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Tencon27 scaffold BC loop

<400>  32

Thr Ala Pro Asp Ala Ala Phe 
1               5           


<210>  33
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Tencon27 scaffold C strand

<400>  33

Asp Ser Phe Leu Ile Gln Tyr Gln Glu 
1               5                   


<210>  34
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Tencon27 scaffold CD loop

<400>  34

Ser Glu Lys Val Gly Glu 
1               5       


<210>  35
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Tencon27 scaffold D strand

<400>  35

Ala Ile Val Leu Thr Val Pro 
1               5           


<210>  36
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Tencon27 scaffold DE loop

<400>  36

Gly Ser Glu Arg 
1               


<210>  37
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Tencon27 scaffold E strand

<400>  37

Ser Tyr Asp Leu Thr 
1               5   


<210>  38
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Tencon27 scaffold EF loop

<400>  38

Gly Leu Lys Pro Gly 
1               5   


<210>  39
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Tencon27 scaffold F strand

<400>  39

Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val 
1               5                   10  


<210>  40
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Tencon27 scaffold FG loop

<400>  40

Lys Gly Gly His Arg Ser Asn 
1               5           


<210>  41
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Tencon27 scaffold G strand

<400>  41

Pro Leu Ser Ala Ile Phe Thr Thr 
1               5               


<210>  42
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Tencon27 scaffold C strand and CD loop

<400>  42

Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu 
1               5                   10                  15  


<210>  43
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Tencon27 scaffold F strand and FG loop

<400>  43

Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser 
1               5                   10                  15      


Asn 
    


<210>  44
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Tencon27 scaffold A strand, AB loop, B strand and BC loop

<400>  44

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
            20                  25              


<210>  45
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TCL14 library C strand


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  45

Asp Ser Phe Xaa Ile Xaa Tyr Xaa Glu 
1               5                   


<210>  46
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TCL14 library F strand


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  46

Thr Glu Tyr Xaa Val Xaa Ile Xaa Gly Val 
1               5                   10  


<210>  47
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TCL14 library C strand and CD loop


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(13)
<223>  Xaa can be any naturally occurring amino acid

<400>  47

Asp Ser Phe Xaa Ile Xaa Tyr Xaa Glu Xaa Xaa Xaa Xaa Gly Glu 
1               5                   10                  15  


<210>  48
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TCL14 library F strand and FG loop


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  48

Thr Glu Tyr Xaa Val Xaa Ile Xaa Gly Val Lys Gly Gly Xaa Xaa Ser 
1               5                   10                  15      


Xaa 
    


<210>  49
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TCL15 library A strand, AB loop, B strand and BC loop


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<400>  49

Leu Pro Ala Pro Lys Xaa Leu Xaa Val Xaa Xaa Val Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Ala Xaa Leu Xaa Trp Xaa Ala Pro Asp Ala Ala Phe 
            20                  25              


<210>  50
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TCL15 library E strand


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  50

Xaa Tyr Xaa Leu Thr 
1               5   


<210>  51
<211>  126
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer


<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  s is g or c

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  s is g or c

<220>
<221>  misc_feature
<222>  (31)..(32)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  s is g or c

<220>
<221>  misc_feature
<222>  (37)..(38)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  s is g or c

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  s is g or c

<220>
<221>  misc_feature
<222>  (43)..(44)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  s is g or c

<220>
<221>  misc_feature
<222>  (46)..(47)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  s is g or c

<400>  51
gcggcgttcg actctttcnn satcnnstac nnsgaannsn nsnnsnnsgg tgaagcgatc       60

ggtctgaccg ttccgggttc tgaacgttct tacgacctga ccggtctgaa accgggtacc      120

gaatac                                                                 126


<210>  52
<211>  102
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer


<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  s is c or g

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  s is c or g

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  s is c or g

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  s is c or g

<220>
<221>  misc_feature
<222>  (53)..(54)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  s is c or g

<220>
<221>  misc_feature
<222>  (59)..(60)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  s is c or g

<220>
<221>  misc_feature
<222>  (65)..(66)
<223>  n is a, c, g, or t

<400>  52
ggtggtgaag atcgcagaca gcggsnnaga snnsnnacca cctttaacac csnngatsnn       60

aacsnngtat tcggtacccg gtttcagacc ggtcaggtcg ta                         102


<210>  53
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  53
gaacgcggct acaattaata cataacc                                           27


<210>  54
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  54
catgattacg ccaagctcag aa                                                22


<210>  55
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  55
aagaaggaga accggtatgc tgccggcgcc gaaaaac                                37


<210>  56
<211>  65
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  56
gagccgccgc caccggttta atggtgatgg tgatggtgac caccggtggt gaagatcgca       60

gacag                                                                   65


<210>  57
<211>  2201
<212>  PRT
<213>  homo sapiens

<400>  57

Met Gly Ala Met Thr Gln Leu Leu Ala Gly Val Phe Leu Ala Phe Leu 
1               5                   10                  15      


Ala Leu Ala Thr Glu Gly Gly Val Leu Lys Lys Val Ile Arg His Lys 
            20                  25                  30          


Arg Gln Ser Gly Val Asn Ala Thr Leu Pro Glu Glu Asn Gln Pro Val 
        35                  40                  45              


Val Phe Asn His Val Tyr Asn Ile Lys Leu Pro Val Gly Ser Gln Cys 
    50                  55                  60                  


Ser Val Asp Leu Glu Ser Ala Ser Gly Glu Lys Asp Leu Ala Pro Pro 
65                  70                  75                  80  


Ser Glu Pro Ser Glu Ser Phe Gln Glu His Thr Val Asp Gly Glu Asn 
                85                  90                  95      


Gln Ile Val Phe Thr His Arg Ile Asn Ile Pro Arg Arg Ala Cys Gly 
            100                 105                 110         


Cys Ala Ala Ala Pro Asp Val Lys Glu Leu Leu Ser Arg Leu Glu Glu 
        115                 120                 125             


Leu Glu Asn Leu Val Ser Ser Leu Arg Glu Gln Cys Thr Ala Gly Ala 
    130                 135                 140                 


Gly Cys Cys Leu Gln Pro Ala Thr Gly Arg Leu Asp Thr Arg Pro Phe 
145                 150                 155                 160 


Cys Ser Gly Arg Gly Asn Phe Ser Thr Glu Gly Cys Gly Cys Val Cys 
                165                 170                 175     


Glu Pro Gly Trp Lys Gly Pro Asn Cys Ser Glu Pro Glu Cys Pro Gly 
            180                 185                 190         


Asn Cys His Leu Arg Gly Arg Cys Ile Asp Gly Gln Cys Ile Cys Asp 
        195                 200                 205             


Asp Gly Phe Thr Gly Glu Asp Cys Ser Gln Leu Ala Cys Pro Ser Asp 
    210                 215                 220                 


Cys Asn Asp Gln Gly Lys Cys Val Asn Gly Val Cys Ile Cys Phe Glu 
225                 230                 235                 240 


Gly Tyr Ala Gly Ala Asp Cys Ser Arg Glu Ile Cys Pro Val Pro Cys 
                245                 250                 255     


Ser Glu Glu His Gly Thr Cys Val Asp Gly Leu Cys Val Cys His Asp 
            260                 265                 270         


Gly Phe Ala Gly Asp Asp Cys Asn Lys Pro Leu Cys Leu Asn Asn Cys 
        275                 280                 285             


Tyr Asn Arg Gly Arg Cys Val Glu Asn Glu Cys Val Cys Asp Glu Gly 
    290                 295                 300                 


Phe Thr Gly Glu Asp Cys Ser Glu Leu Ile Cys Pro Asn Asp Cys Phe 
305                 310                 315                 320 


Asp Arg Gly Arg Cys Ile Asn Gly Thr Cys Tyr Cys Glu Glu Gly Phe 
                325                 330                 335     


Thr Gly Glu Asp Cys Gly Lys Pro Thr Cys Pro His Ala Cys His Thr 
            340                 345                 350         


Gln Gly Arg Cys Glu Glu Gly Gln Cys Val Cys Asp Glu Gly Phe Ala 
        355                 360                 365             


Gly Val Asp Cys Ser Glu Lys Arg Cys Pro Ala Asp Cys His Asn Arg 
    370                 375                 380                 


Gly Arg Cys Val Asp Gly Arg Cys Glu Cys Asp Asp Gly Phe Thr Gly 
385                 390                 395                 400 


Ala Asp Cys Gly Glu Leu Lys Cys Pro Asn Gly Cys Ser Gly His Gly 
                405                 410                 415     


Arg Cys Val Asn Gly Gln Cys Val Cys Asp Glu Gly Tyr Thr Gly Glu 
            420                 425                 430         


Asp Cys Ser Gln Leu Arg Cys Pro Asn Asp Cys His Ser Arg Gly Arg 
        435                 440                 445             


Cys Val Glu Gly Lys Cys Val Cys Glu Gln Gly Phe Lys Gly Tyr Asp 
    450                 455                 460                 


Cys Ser Asp Met Ser Cys Pro Asn Asp Cys His Gln His Gly Arg Cys 
465                 470                 475                 480 


Val Asn Gly Met Cys Val Cys Asp Asp Gly Tyr Thr Gly Glu Asp Cys 
                485                 490                 495     


Arg Asp Arg Gln Cys Pro Arg Asp Cys Ser Asn Arg Gly Leu Cys Val 
            500                 505                 510         


Asp Gly Gln Cys Val Cys Glu Asp Gly Phe Thr Gly Pro Asp Cys Ala 
        515                 520                 525             


Glu Leu Ser Cys Pro Asn Asp Cys His Gly Gln Gly Arg Cys Val Asn 
    530                 535                 540                 


Gly Gln Cys Val Cys His Glu Gly Phe Met Gly Lys Asp Cys Lys Glu 
545                 550                 555                 560 


Gln Arg Cys Pro Ser Asp Cys His Gly Gln Gly Arg Cys Val Asp Gly 
                565                 570                 575     


Gln Cys Ile Cys His Glu Gly Phe Thr Gly Leu Asp Cys Gly Gln His 
            580                 585                 590         


Ser Cys Pro Ser Asp Cys Asn Asn Leu Gly Gln Cys Val Ser Gly Arg 
        595                 600                 605             


Cys Ile Cys Asn Glu Gly Tyr Ser Gly Glu Asp Cys Ser Glu Val Ser 
    610                 615                 620                 


Pro Pro Lys Asp Leu Val Val Thr Glu Val Thr Glu Glu Thr Val Asn 
625                 630                 635                 640 


Leu Ala Trp Asp Asn Glu Met Arg Val Thr Glu Tyr Leu Val Val Tyr 
                645                 650                 655     


Thr Pro Thr His Glu Gly Gly Leu Glu Met Gln Phe Arg Val Pro Gly 
            660                 665                 670         


Asp Gln Thr Ser Thr Ile Ile Gln Glu Leu Glu Pro Gly Val Glu Tyr 
        675                 680                 685             


Phe Ile Arg Val Phe Ala Ile Leu Glu Asn Lys Lys Ser Ile Pro Val 
    690                 695                 700                 


Ser Ala Arg Val Ala Thr Tyr Leu Pro Ala Pro Glu Gly Leu Lys Phe 
705                 710                 715                 720 


Lys Ser Ile Lys Glu Thr Ser Val Glu Val Glu Trp Asp Pro Leu Asp 
                725                 730                 735     


Ile Ala Phe Glu Thr Trp Glu Ile Ile Phe Arg Asn Met Asn Lys Glu 
            740                 745                 750         


Asp Glu Gly Glu Ile Thr Lys Ser Leu Arg Arg Pro Glu Thr Ser Tyr 
        755                 760                 765             


Arg Gln Thr Gly Leu Ala Pro Gly Gln Glu Tyr Glu Ile Ser Leu His 
    770                 775                 780                 


Ile Val Lys Asn Asn Thr Arg Gly Pro Gly Leu Lys Arg Val Thr Thr 
785                 790                 795                 800 


Thr Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp 
                805                 810                 815     


Thr Thr Ala Leu Ile Thr Trp Phe Lys Pro Leu Ala Glu Ile Asp Gly 
            820                 825                 830         


Ile Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr 
        835                 840                 845             


Ile Asp Leu Thr Glu Asp Glu Asn Gln Tyr Ser Ile Gly Asn Leu Lys 
    850                 855                 860                 


Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Arg Arg Gly Asp Met 
865                 870                 875                 880 


Ser Ser Asn Pro Ala Lys Glu Thr Phe Thr Thr Gly Leu Asp Ala Pro 
                885                 890                 895     


Arg Asn Leu Arg Arg Val Ser Gln Thr Asp Asn Ser Ile Thr Leu Glu 
            900                 905                 910         


Trp Arg Asn Gly Lys Ala Ala Ile Asp Ser Tyr Arg Ile Lys Tyr Ala 
        915                 920                 925             


Pro Ile Ser Gly Gly Asp His Ala Glu Val Asp Val Pro Lys Ser Gln 
    930                 935                 940                 


Gln Ala Thr Thr Lys Thr Thr Leu Thr Gly Leu Arg Pro Gly Thr Glu 
945                 950                 955                 960 


Tyr Gly Ile Gly Val Ser Ala Val Lys Glu Asp Lys Glu Ser Asn Pro 
                965                 970                 975     


Ala Thr Ile Asn Ala Ala Thr Glu Leu Asp Thr Pro Lys Asp Leu Gln 
            980                 985                 990         


Val Ser Glu Thr Ala Glu Thr Ser  Leu Thr Leu Leu Trp  Lys Thr Pro 
        995                 1000                 1005             


Leu Ala  Lys Phe Asp Arg Tyr  Arg Leu Asn Tyr Ser  Leu Pro Thr 
    1010                 1015                 1020             


Gly Gln  Trp Val Gly Val Gln  Leu Pro Arg Asn Thr  Thr Ser Tyr 
    1025                 1030                 1035             


Val Leu  Arg Gly Leu Glu Pro  Gly Gln Glu Tyr Asn  Val Leu Leu 
    1040                 1045                 1050             


Thr Ala  Glu Lys Gly Arg His  Lys Ser Lys Pro Ala  Arg Val Lys 
    1055                 1060                 1065             


Ala Ser  Thr Glu Gln Ala Pro  Glu Leu Glu Asn Leu  Thr Val Thr 
    1070                 1075                 1080             


Glu Val  Gly Trp Asp Gly Leu  Arg Leu Asn Trp Thr  Ala Ala Asp 
    1085                 1090                 1095             


Gln Ala  Tyr Glu His Phe Ile  Ile Gln Val Gln Glu  Ala Asn Lys 
    1100                 1105                 1110             


Val Glu  Ala Ala Arg Asn Leu  Thr Val Pro Gly Ser  Leu Arg Ala 
    1115                 1120                 1125             


Val Asp  Ile Pro Gly Leu Lys  Ala Ala Thr Pro Tyr  Thr Val Ser 
    1130                 1135                 1140             


Ile Tyr  Gly Val Ile Gln Gly  Tyr Arg Thr Pro Val  Leu Ser Ala 
    1145                 1150                 1155             


Glu Ala  Ser Thr Gly Glu Thr  Pro Asn Leu Gly Glu  Val Val Val 
    1160                 1165                 1170             


Ala Glu  Val Gly Trp Asp Ala  Leu Lys Leu Asn Trp  Thr Ala Pro 
    1175                 1180                 1185             


Glu Gly  Ala Tyr Glu Tyr Phe  Phe Ile Gln Val Gln  Glu Ala Asp 
    1190                 1195                 1200             


Thr Val  Glu Ala Ala Gln Asn  Leu Thr Val Pro Gly  Gly Leu Arg 
    1205                 1210                 1215             


Ser Thr  Asp Leu Pro Gly Leu  Lys Ala Ala Thr His  Tyr Thr Ile 
    1220                 1225                 1230             


Thr Ile  Arg Gly Val Thr Gln  Asp Phe Ser Thr Thr  Pro Leu Ser 
    1235                 1240                 1245             


Val Glu  Val Leu Thr Glu Glu  Val Pro Asp Met Gly  Asn Leu Thr 
    1250                 1255                 1260             


Val Thr  Glu Val Ser Trp Asp  Ala Leu Arg Leu Asn  Trp Thr Thr 
    1265                 1270                 1275             


Pro Asp  Gly Thr Tyr Asp Gln  Phe Thr Ile Gln Val  Gln Glu Ala 
    1280                 1285                 1290             


Asp Gln  Val Glu Glu Ala His  Asn Leu Thr Val Pro  Gly Ser Leu 
    1295                 1300                 1305             


Arg Ser  Met Glu Ile Pro Gly  Leu Arg Ala Gly Thr  Pro Tyr Thr 
    1310                 1315                 1320             


Val Thr  Leu His Gly Glu Val  Arg Gly His Ser Thr  Arg Pro Leu 
    1325                 1330                 1335             


Ala Val  Glu Val Val Thr Glu  Asp Leu Pro Gln Leu  Gly Asp Leu 
    1340                 1345                 1350             


Ala Val  Ser Glu Val Gly Trp  Asp Gly Leu Arg Leu  Asn Trp Thr 
    1355                 1360                 1365             


Ala Ala  Asp Asn Ala Tyr Glu  His Phe Val Ile Gln  Val Gln Glu 
    1370                 1375                 1380             


Val Asn  Lys Val Glu Ala Ala  Gln Asn Leu Thr Leu  Pro Gly Ser 
    1385                 1390                 1395             


Leu Arg  Ala Val Asp Ile Pro  Gly Leu Glu Ala Ala  Thr Pro Tyr 
    1400                 1405                 1410             


Arg Val  Ser Ile Tyr Gly Val  Ile Arg Gly Tyr Arg  Thr Pro Val 
    1415                 1420                 1425             


Leu Ser  Ala Glu Ala Ser Thr  Ala Lys Glu Pro Glu  Ile Gly Asn 
    1430                 1435                 1440             


Leu Asn  Val Ser Asp Ile Thr  Pro Glu Ser Phe Asn  Leu Ser Trp 
    1445                 1450                 1455             


Met Ala  Thr Asp Gly Ile Phe  Glu Thr Phe Thr Ile  Glu Ile Ile 
    1460                 1465                 1470             


Asp Ser  Asn Arg Leu Leu Glu  Thr Val Glu Tyr Asn  Ile Ser Gly 
    1475                 1480                 1485             


Ala Glu  Arg Thr Ala His Ile  Ser Gly Leu Pro Pro  Ser Thr Asp 
    1490                 1495                 1500             


Phe Ile  Val Tyr Leu Ser Gly  Leu Ala Pro Ser Ile  Arg Thr Lys 
    1505                 1510                 1515             


Thr Ile  Ser Ala Thr Ala Thr  Thr Glu Ala Leu Pro  Leu Leu Glu 
    1520                 1525                 1530             


Asn Leu  Thr Ile Ser Asp Ile  Asn Pro Tyr Gly Phe  Thr Val Ser 
    1535                 1540                 1545             


Trp Met  Ala Ser Glu Asn Ala  Phe Asp Ser Phe Leu  Val Thr Val 
    1550                 1555                 1560             


Val Asp  Ser Gly Lys Leu Leu  Asp Pro Gln Glu Phe  Thr Leu Ser 
    1565                 1570                 1575             


Gly Thr  Gln Arg Lys Leu Glu  Leu Arg Gly Leu Ile  Thr Gly Ile 
    1580                 1585                 1590             


Gly Tyr  Glu Val Met Val Ser  Gly Phe Thr Gln Gly  His Gln Thr 
    1595                 1600                 1605             


Lys Pro  Leu Arg Ala Glu Ile  Val Thr Glu Ala Glu  Pro Glu Val 
    1610                 1615                 1620             


Asp Asn  Leu Leu Val Ser Asp  Ala Thr Pro Asp Gly  Phe Arg Leu 
    1625                 1630                 1635             


Ser Trp  Thr Ala Asp Glu Gly  Val Phe Asp Asn Phe  Val Leu Lys 
    1640                 1645                 1650             


Ile Arg  Asp Thr Lys Lys Gln  Ser Glu Pro Leu Glu  Ile Thr Leu 
    1655                 1660                 1665             


Leu Ala  Pro Glu Arg Thr Arg  Asp Ile Thr Gly Leu  Arg Glu Ala 
    1670                 1675                 1680             


Thr Glu  Tyr Glu Ile Glu Leu  Tyr Gly Ile Ser Lys  Gly Arg Arg 
    1685                 1690                 1695             


Ser Gln  Thr Val Ser Ala Ile  Ala Thr Thr Ala Met  Gly Ser Pro 
    1700                 1705                 1710             


Lys Glu  Val Ile Phe Ser Asp  Ile Thr Glu Asn Ser  Ala Thr Val 
    1715                 1720                 1725             


Ser Trp  Arg Ala Pro Thr Ala  Gln Val Glu Ser Phe  Arg Ile Thr 
    1730                 1735                 1740             


Tyr Val  Pro Ile Thr Gly Gly  Thr Pro Ser Met Val  Thr Val Asp 
    1745                 1750                 1755             


Gly Thr  Lys Thr Gln Thr Arg  Leu Val Lys Leu Ile  Pro Gly Val 
    1760                 1765                 1770             


Glu Tyr  Leu Val Ser Ile Ile  Ala Met Lys Gly Phe  Glu Glu Ser 
    1775                 1780                 1785             


Glu Pro  Val Ser Gly Ser Phe  Thr Thr Ala Leu Asp  Gly Pro Ser 
    1790                 1795                 1800             


Gly Leu  Val Thr Ala Asn Ile  Thr Asp Ser Glu Ala  Leu Ala Arg 
    1805                 1810                 1815             


Trp Gln  Pro Ala Ile Ala Thr  Val Asp Ser Tyr Val  Ile Ser Tyr 
    1820                 1825                 1830             


Thr Gly  Glu Lys Val Pro Glu  Ile Thr Arg Thr Val  Ser Gly Asn 
    1835                 1840                 1845             


Thr Val  Glu Tyr Ala Leu Thr  Asp Leu Glu Pro Ala  Thr Glu Tyr 
    1850                 1855                 1860             


Thr Leu  Arg Ile Phe Ala Glu  Lys Gly Pro Gln Lys  Ser Ser Thr 
    1865                 1870                 1875             


Ile Thr  Ala Lys Phe Thr Thr  Asp Leu Asp Ser Pro  Arg Asp Leu 
    1880                 1885                 1890             


Thr Ala  Thr Glu Val Gln Ser  Glu Thr Ala Leu Leu  Thr Trp Arg 
    1895                 1900                 1905             


Pro Pro  Arg Ala Ser Val Thr  Gly Tyr Leu Leu Val  Tyr Glu Ser 
    1910                 1915                 1920             


Val Asp  Gly Thr Val Lys Glu  Val Ile Val Gly Pro  Asp Thr Thr 
    1925                 1930                 1935             


Ser Tyr  Ser Leu Ala Asp Leu  Ser Pro Ser Thr His  Tyr Thr Ala 
    1940                 1945                 1950             


Lys Ile  Gln Ala Leu Asn Gly  Pro Leu Arg Ser Asn  Met Ile Gln 
    1955                 1960                 1965             


Thr Ile  Phe Thr Thr Ile Gly  Leu Leu Tyr Pro Phe  Pro Lys Asp 
    1970                 1975                 1980             


Cys Ser  Gln Ala Met Leu Asn  Gly Asp Thr Thr Ser  Gly Leu Tyr 
    1985                 1990                 1995             


Thr Ile  Tyr Leu Asn Gly Asp  Lys Ala Glu Ala Leu  Glu Val Phe 
    2000                 2005                 2010             


Cys Asp  Met Thr Ser Asp Gly  Gly Gly Trp Ile Val  Phe Leu Arg 
    2015                 2020                 2025             


Arg Lys  Asn Gly Arg Glu Asn  Phe Tyr Gln Asn Trp  Lys Ala Tyr 
    2030                 2035                 2040             


Ala Ala  Gly Phe Gly Asp Arg  Arg Glu Glu Phe Trp  Leu Gly Leu 
    2045                 2050                 2055             


Asp Asn  Leu Asn Lys Ile Thr  Ala Gln Gly Gln Tyr  Glu Leu Arg 
    2060                 2065                 2070             


Val Asp  Leu Arg Asp His Gly  Glu Thr Ala Phe Ala  Val Tyr Asp 
    2075                 2080                 2085             


Lys Phe  Ser Val Gly Asp Ala  Lys Thr Arg Tyr Lys  Leu Lys Val 
    2090                 2095                 2100             


Glu Gly  Tyr Ser Gly Thr Ala  Gly Asp Ser Met Ala  Tyr His Asn 
    2105                 2110                 2115             


Gly Arg  Ser Phe Ser Thr Phe  Asp Lys Asp Thr Asp  Ser Ala Ile 
    2120                 2125                 2130             


Thr Asn  Cys Ala Leu Ser Tyr  Lys Gly Ala Phe Trp  Tyr Arg Asn 
    2135                 2140                 2145             


Cys His  Arg Val Asn Leu Met  Gly Arg Tyr Gly Asp  Asn Asn His 
    2150                 2155                 2160             


Ser Gln  Gly Val Asn Trp Phe  His Trp Lys Gly His  Glu His Ser 
    2165                 2170                 2175             


Ile Gln  Phe Ala Glu Met Lys  Leu Arg Pro Ser Asn  Phe Arg Asn 
    2180                 2185                 2190             


Leu Glu  Gly Arg Arg Lys Arg  Ala 
    2195                 2200     


<210>  58
<211>  89
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FN3 scaffold based on consensuns fibronecting FN3 domains

<400>  58

Leu Asp Ala Pro Thr Asp Leu Gln Val Thr Asn Val Thr Asp Thr Ser 
1               5                   10                  15      


Ile Thr Val Ser Trp Thr Pro Pro Ser Ala Thr Ile Thr Gly Tyr Arg 
            20                  25                  30          


Ile Thr Tyr Thr Pro Ser Asn Gly Pro Gly Glu Pro Lys Glu Leu Thr 
        35                  40                  45              


Val Pro Pro Ser Ser Thr Ser Val Thr Ile Thr Gly Leu Thr Pro Gly 
    50                  55                  60                  


Val Glu Tyr Val Val Ser Leu Tyr Ala Leu Lys Asp Asn Gln Glu Ser 
65                  70                  75                  80  


Pro Pro Leu Val Gly Thr Gln Thr Thr 
                85                  


<210>  59
<211>  267
<212>  DNA
<213>  Artificial sequence

<220>
<223>  cDNA encoding tencon scaffold

<400>  59
ctgccggcgc cgaaaaacct ggttgtttct gaagttaccg aagactctct gcgtctgtct       60

tggaccgcgc cggacgcggc gttcgactct ttcctgatcc agtaccagga atctgaaaaa      120

gttggtgaag cgatcaacct gaccgttccg ggttctgaac gttcttacga cctgaccggt      180

ctgaaaccgg gtaccgaata caccgtttct atctacggtg ttaaaggtgg tcaccgttct      240

aacccgctgt ctgcggaatt caccacc                                          267


<210>  60
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  60

Thr Ser Gly Gly Gly Gly Ser 
1               5           


<210>  61
<211>  89
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TCL15 library on tencon27 having randomized A-AB-B-BC-E surface


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  Xaa can be any naturally occurring amino acid

<400>  61

Leu Pro Ala Pro Lys Xaa Leu Xaa Val Xaa Xaa Val Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Ala Xaa Leu Xaa Trp Xaa Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Xaa Tyr Xaa Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  62
<211>  89
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fibcon library with randomized C-CD-F-FG surface


<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (38)..(41)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (78)..(79)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (81)..(81)
<223>  Xaa can be any naturally occurring amino acid

<400>  62

Leu Asp Ala Pro Thr Asp Leu Gln Val Thr Asn Val Thr Asp Thr Ser 
1               5                   10                  15      


Ile Thr Val Ser Trp Thr Pro Pro Ser Ala Thr Ile Thr Gly Tyr Xaa 
            20                  25                  30          


Ile Xaa Tyr Xaa Pro Xaa Xaa Xaa Xaa Gly Glu Pro Lys Glu Leu Thr 
        35                  40                  45              


Val Pro Pro Ser Ser Thr Ser Val Thr Ile Thr Gly Leu Thr Pro Gly 
    50                  55                  60                  


Val Glu Tyr Xaa Val Xaa Leu Xaa Ala Leu Lys Asp Asn Xaa Xaa Ser 
65                  70                  75                  80  


Xaa Pro Leu Val Gly Thr Gln Thr Thr 
                85                  


<210>  63
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C strand sequence of scaffold TP1KR9P61-A2

<400>  63

Asp Ser Phe Ala Ile Glu Tyr Phe Glu 
1               5                   


<210>  64
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C strand sequence of clone TP1KR9P62-A2

<400>  64

Asp Ser Phe Ala Ile Glu Tyr Ser Glu 
1               5                   


<210>  65
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C strand sequence of clone TP1KR9P62-D4

<400>  65

Asp Ser Phe Gly Ile Ile Tyr Phe Glu 
1               5                   


<210>  66
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C strand sequence of clone TP1KR9P62-E3

<400>  66

Asp Ser Phe Gly Ile Glu Tyr Phe Glu 
1               5                   


<210>  67
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>   CD loop of TP1KR9P61-A2

<400>  67

Asp Trp Trp Ser Gly Glu 
1               5       


<210>  68
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD loop of TP1KR9P62-A2

<400>  68

Asp Tyr Trp Leu Gly Glu 
1               5       


<210>  69
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD loop of TP1KR9P62-D4

<400>  69

Asp Trp Trp Ala Gly Glu 
1               5       


<210>  70
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD loop of TP1KR9P62-E3

<400>  70

Asp Tyr Trp Thr Gly Glu 
1               5       


<210>  71
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  F strand of TP1KR9P61-A2

<400>  71

Thr Glu Tyr Ala Val Ser Ile Arg Gly Val 
1               5                   10  


<210>  72
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  F strand of TP1KR9P61-A7

<400>  72

Thr Glu Tyr Ser Val Ser Ile Arg Gly Val 
1               5                   10  


<210>  73
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TP1KR9P62-A2

<400>  73

Thr Glu Tyr Gly Val Ser Ile Arg Gly Val 
1               5                   10  


<210>  74
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  F strand of TP1KR9P62-C3

<400>  74

Thr Glu Tyr Ser Val Thr Ile Arg Gly Val 
1               5                   10  


<210>  75
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FG loop of TP1KR9P61-A2

<400>  75

Lys Gly Gly Met Pro Ser Ala 
1               5           


<210>  76
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FG loop of TP1KR9P61-A7

<400>  76

Lys Gly Gly Tyr Pro Ser Ser 
1               5           


<210>  77
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FG loop of TP1KR9P61-E2

<400>  77

Lys Gly Gly Met Pro Ser Pro 
1               5           


<210>  78
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FG loop of TP1KR9P61-G4

<400>  78

Lys Gly Gly Tyr Pro Ser Ala 
1               5           


<210>  79
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FG loop of TP1KR9P62-A2

<400>  79

Lys Gly Gly Tyr Pro Ser Pro 
1               5           


<210>  80
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FG loop of TP1KR9P62-C3

<400>  80

Lys Gly Gly Pro Pro Ser Ser 
1               5           


<210>  81
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FG loop of TP1KR9P62-C6

<400>  81

Lys Gly Gly Tyr Pro Ser Ser 
1               5           


<210>  82
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FG loop of TP1KR9P62-D4

<400>  82

Lys Gly Gly Pro Pro Ser Arg 
1               5           


<210>  83
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FG loop of TP1KR9P62-D8

<400>  83

Lys Gly Gly Leu Ala Ser Pro 
1               5           


<210>  84
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FG loop of TP1KR9P62-H10

<400>  84

Lys Gly Gly His Pro Ser Val 
1               5           


<210>  85
<211>  90
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mIL-17A binding scaffold TP1KR9P61-A2

<400>  85

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Phe Glu Asp Trp Trp Ser Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ala Val Ser Ile Arg Gly Val Lys Gly Gly Met Pro 
65                  70                  75                  80  


Ser Ala Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90  


<210>  86
<211>  90
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mIL-17A binding scaffold TP1KR9P61-A7

<400>  86

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Phe Glu Asp Trp Trp Ser Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ser Val Ser Ile Arg Gly Val Lys Gly Gly Tyr Pro 
65                  70                  75                  80  


Ser Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90  


<210>  87
<211>  90
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mIL-17A binding scaffold TP1KR9P61-E2

<400>  87

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Phe Glu Asp Trp Trp Ser Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ala Val Ser Ile Arg Gly Val Lys Gly Gly Met Pro 
65                  70                  75                  80  


Ser Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90  


<210>  88
<211>  90
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mIL-17A binding scaffold TP1KR9P61-G4

<400>  88

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Phe Glu Asp Trp Trp Ser Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ala Val Ser Ile Arg Gly Val Lys Gly Gly Tyr Pro 
65                  70                  75                  80  


Ser Ala Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90  


<210>  89
<211>  90
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mIL-17A binding scaffold TP1KR9P62-A2

<400>  89

Met Leu Pro Ala Leu Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala His Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Ser Glu Asp Tyr Trp Leu Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Gly Val Ser Ile Arg Gly Val Lys Gly Gly Tyr Pro 
65                  70                  75                  80  


Ser Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90  


<210>  90
<211>  90
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mIL-17A binding scaffold TP1KR9P62-C3

<400>  90

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Phe Glu Asp Trp Trp Ser Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ser Val Thr Ile Arg Gly Val Lys Gly Gly Pro Pro 
65                  70                  75                  80  


Ser Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90  


<210>  91
<211>  90
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mIL-17A binding scaffold TP1KR9P62-C6

<400>  91

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Phe Glu Asp Trp Trp Ser Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Cys Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ser Val Thr Ile Arg Gly Val Lys Gly Gly Tyr Pro 
65                  70                  75                  80  


Ser Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90  


<210>  92
<211>  89
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mIL-17A binding scaffold TP1KR9P62-D3

<400>  92

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Phe Glu Asp Trp Trp Ser Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ser Val Ser Ile Arg Gly Val Lys Gly Gly Tyr Pro Ser 
65                  70                  75                  80  


Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  93
<211>  90
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mIL-17A binding scaffold TP1KR9P62-D4

<400>  93

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Gly Ile Ile Tyr Phe Glu Asp Trp Trp Ala Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Gly Val Ser Ile Arg Gly Val Lys Gly Gly Pro Pro 
65                  70                  75                  80  


Ser Arg Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90  


<210>  94
<211>  90
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mIL-17A binding scaffold TP1KR9P62-D8

<400>  94

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Phe Glu Asp Trp Trp Ser Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Gly Val Ser Ile Arg Gly Val Lys Gly Gly Leu Ala 
65                  70                  75                  80  


Ser Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90  


<210>  95
<211>  90
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mIL-17A binding scaffold TP1KR9P62-E3

<400>  95

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Gly Ile Glu Tyr Phe Glu Asp Tyr Trp Thr Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ala Val Ser Ile Arg Gly Val Lys Gly Gly Tyr Pro 
65                  70                  75                  80  


Ser Ala Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90  


<210>  96
<211>  90
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mIL-17A binding scaffold TP1KR9P62-H10

<400>  96

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Phe Glu Asp Trp Trp Ser Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ser Val Ser Ile Arg Gly Val Lys Gly Gly His Pro 
65                  70                  75                  80  


Ser Val Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90  


<210>  97
<211>  94
<212>  PRT
<213>  homo sapiens

<400>  97

Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 
1               5                   10                  15      


Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr 
            20                  25                  30          


Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 
        35                  40                  45              


Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 
    50                  55                  60                  


Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Asp 
65                  70                  75                  80  


Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  


<210>  98
<211>  94
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FN10 based scaffold library with randomized C-CD-F-FG surface


<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (39)..(42)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (83)..(84)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  Xaa can be any naturally occurring amino acid

<400>  98

Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 
1               5                   10                  15      


Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr 
            20                  25                  30          


Xaa Ile Xaa Tyr Xaa Glu Xaa Xaa Xaa Xaa Ser Pro Val Gln Glu Phe 
        35                  40                  45              


Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 
    50                  55                  60                  


Gly Val Asp Tyr Xaa Ile Xaa Val Xaa Ala Val Thr Gly Arg Gly Asp 
65                  70                  75                  80  


Ser Pro Xaa Xaa Ser Xaa Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  


<210>  99
<211>  88
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TN3 based scaffodl library with randomized C-CD-F-FG surface


<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (37)..(40)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (77)..(78)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa can be any naturally occurring amino acid

<400>  99

Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr Thr Ala 
1               5                   10                  15      


Leu Ile Thr Trp Phe Lys Pro Leu Ala Glu Ile Asp Gly Ile Xaa Leu 
            20                  25                  30          


Xaa Tyr Xaa Ile Xaa Xaa Xaa Xaa Gly Asp Arg Thr Thr Ile Asp Leu 
        35                  40                  45              


Thr Glu Asp Glu Asn Gln Tyr Ser Ile Gly Asn Leu Lys Pro Asp Thr 
    50                  55                  60                  


Glu Tyr Xaa Val Xaa Leu Xaa Ser Arg Arg Gly Asp Xaa Xaa Ser Xaa 
65                  70                  75                  80  


Pro Ala Lys Glu Thr Phe Thr Thr 
                85              


<210>  100
<211>  270
<212>  DNA
<213>  Artificial sequence

<220>
<223>  cDNA encoding tencon27

<400>  100
atgctgccgg cgccgaaaaa cctggttgtt tctcgtgtta ccgaagactc tgcgcgtctg       60

tcttggaccg cgccggacgc ggcgttcgac tctttcctga tccagtacca ggaatctgaa      120

aaagttggtg aagcgatcgt tctgaccgtt ccgggttctg aacgttctta cgacctgacc      180

ggtctgaaac cgggtaccga atacaccgtt tctatctacg gtgttaaagg tggtcaccgt      240

tctaacccgc tgtctgcgat cttcaccacc                                       270


<210>  101
<211>  270
<212>  DNA
<213>  Artificial sequence

<220>
<223>  cDNA encoding TCL14 library




<220>
<221>  misc_feature
<222>  (97)..(98)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (99)..(99)
<223>  s is c or g

<220>
<221>  misc_feature
<222>  (103)..(104)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  s is c or g

<220>
<221>  misc_feature
<222>  (109)..(110)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (111)..(111)
<223>  s is c or g

<220>
<221>  misc_feature
<222>  (115)..(116)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (117)..(117)
<223>  s is c or g

<220>
<221>  misc_feature
<222>  (118)..(119)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (120)..(120)
<223>  s is c or g

<220>
<221>  misc_feature
<222>  (121)..(122)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (123)..(123)
<223>  s is c or g

<220>
<221>  misc_feature
<222>  (124)..(125)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (126)..(126)
<223>  s is c or g

<220>
<221>  misc_feature
<222>  (205)..(206)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (207)..(207)
<223>  s is c or g

<220>
<221>  misc_feature
<222>  (211)..(212)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (213)..(213)
<223>  s is c or g

<220>
<221>  misc_feature
<222>  (217)..(218)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (219)..(219)
<223>  s is c or g

<220>
<221>  misc_feature
<222>  (235)..(236)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (237)..(237)
<223>  s is c or g

<220>
<221>  misc_feature
<222>  (238)..(239)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (240)..(240)
<223>  s is c or g

<220>
<221>  misc_feature
<222>  (244)..(245)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (246)..(246)
<223>  s is c or g

<400>  101
atgctgccgg cgccgaaaaa cctggttgtt tctcgtgtta ccgaagactc tgcgcgtctg       60

tcttggaccg cgccggacgc ggcgttcgac tctttcnnsa tcnnstacnn sgaannsnns      120

nnsnnsggtg aagcgatcgt tctgaccgtt ccgggttctg aacgttctta cgacctgacc      180

ggtctgaaac cgggtaccga atacnnsgtt nnsatcnnsg gtgttaaagg tggtnnsnns      240

tctnnsccgc tgtctgcgat cttcaccacc                                       270


