
                                SEQUENCE LISTING

<110> Geierstanger, Bernhard
      Cellitti, Susan
      Loew, Andreas
      Boettcher, Brian
      Daniels, Doug
      Caplan, Shari
      Hamamatsu, Norio
      Weldon, Stephen
      Licht, Stuart

<120> DUAL FUNCTION PROTEINS FOR TREATING
  METABOLIC DISORDERS

<130> PAT054621

<160> 132

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 209
<212> PRT
<213> Homo sapiens

<400> 1
Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser
 1               5                  10                  15      
Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro
            20                  25                  30          
Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr
        35                  40                  45              
Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg
    50                  55                  60                  
Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu
65                  70                  75                  80  
Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val
                85                  90                  95      
Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly
            100                 105                 110         
Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu
        115                 120                 125             
Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu
    130                 135                 140                 
His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly
145                 150                 155                 160 
Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu
                165                 170                 175     
Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp
            180                 185                 190         
Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala
        195                 200                 205             
Ser
    


<210> 2
<211> 940
<212> DNA
<213> Homo sapiens

<400> 2
ctgtcagctg aggatccagc cgaaagagga gccaggcact caggccacct gagtctactc 60
acctggacaa ctggaatctg gcaccaattc taaaccactc agcttctccg agctcacacc 120
ccggagatca cctgaggacc cgagccattg atggactcgg acgagaccgg gttcgagcac 180
tcaggactgt gggtttctgt gctggctggt cttctgctgg gagcctgcca ggcacacccc 240
atccctgact ccagtcctct cctgcaattc gggggccaag tccggcagcg gtacctctac 300
acagatgatg cccagcagac agaagcccac ctggagatca gggaggatgg gacggtgggg 360
ggcgctgctg accagagccc cgaaagtctc ctgcagctga aagccttgaa gccgggagtt 420
attcaaatct tgggagtcaa gacatccagg ttcctgtgcc agcggccaga tggggccctg 480
tatggatcgc tccactttga ccctgaggcc tgcagcttcc gggagctgct tcttgaggac 540
ggatacaatg tttaccagtc cgaagcccac ggcctcccgc tgcacctgcc agggaacaag 600
tccccacacc gggaccctgc accccgagga ccagctcgct tcctgccact accaggcctg 660
ccccccgcac tcccggagcc acccggaatc ctggcccccc agccccccga tgtgggctcc 720
tcggaccctc tgagcatggt gggaccttcc cagggccgaa gccccagcta cgcttcctga 780
agccagaggc tgtttactat gacatctcct ctttatttat taggttattt atcttattta 840
tttttttatt tttcttactt gagataataa agagttccag aggagaaaaa aaaaaaaaaa 900
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                       940

<210> 3
<211> 181
<212> PRT
<213> Homo sapiens

<400> 3
His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val
 1               5                  10                  15      
Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His
            20                  25                  30          
Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser
        35                  40                  45              
Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln
    50                  55                  60                  
Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly
65                  70                  75                  80  
Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg
                85                  90                  95      
Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His
            100                 105                 110         
Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro
        115                 120                 125             
Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro
    130                 135                 140                 
Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val
145                 150                 155                 160 
Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser
                165                 170                 175     
Pro Ser Tyr Ala Ser
            180     


<210> 4
<211> 546
<212> DNA
<213> Homo sapiens

<400> 4
caccccatcc ctgactccag tcctctcctg caattcgggg gccaagtccg gcagcggtac 60
ctctacacag atgatgccca gcagacagaa gcccacctgg agatcaggga ggatgggacg 120
gtggggggcg ctgctgacca gagccccgaa agtctcctgc agctgaaagc cttgaagccg 180
ggagttattc aaatcttggg agtcaagaca tccaggttcc tgtgccagcg gccagatggg 240
gccctgtatg gatcgctcca ctttgaccct gaggcctgca gcttccggga gctgcttctt 300
gaggacggat acaatgttta ccagtccgaa gcccacggcc tcccgctgca cctgccaggg 360
aacaagtccc cacaccggga ccctgcaccc cgaggaccag ctcgcttcct gccactacca 420
ggcctgcccc ccgcactccc ggagccaccc ggaatcctgg ccccccagcc ccccgatgtg 480
ggctcctcgg accctctgag catggtggga ccttcccagg gccgaagccc cagctacgct 540
tcctga                                                            546

<210> 5
<211> 180
<212> PRT
<213> Homo sapiens

<400> 5
Met Lys Ser Ile Tyr Phe Val Ala Gly Leu Phe Val Met Leu Val Gln
 1               5                  10                  15      
Gly Ser Trp Gln Arg Ser Leu Gln Asp Thr Glu Glu Lys Ser Arg Ser
            20                  25                  30          
Phe Ser Ala Ser Gln Ala Asp Pro Leu Ser Asp Pro Asp Gln Met Asn
        35                  40                  45              
Glu Asp Lys Arg His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys
    50                  55                  60                  
Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn
65                  70                  75                  80  
Thr Lys Arg Asn Arg Asn Asn Ile Ala Lys Arg His Asp Glu Phe Glu
                85                  90                  95      
Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu
            100                 105                 110         
Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly
        115                 120                 125             
Arg Arg Asp Phe Pro Glu Glu Val Ala Ile Val Glu Glu Leu Gly Arg
    130                 135                 140                 
Arg His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp
145                 150                 155                 160 
Asn Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile
                165                 170                 175     
Thr Asp Arg Lys
            180 


<210> 6
<211> 1298
<212> DNA
<213> Homo sapiens

<400> 6
gcatagaatg cagatgagca aagtgagtgg gagagggaag tcatttgtaa caaaaactca 60
ttatttacag atgagaaatt tatattgtca gcgtaatatc tgtgaggcta aacagagctg 120
gagagtatat aaaagcagtg cgccttggtg cagaagtaca gagcttagga cacagagcac 180
atcaaaagtt cccaaagagg gcttgctctc tcttcacctg ctctgttcta cagcacacta 240
ccagaagaca gcagaaatga aaagcattta ctttgtggct ggattatttg taatgctggt 300
acaaggcagc tggcaacgtt cccttcaaga cacagaggag aaatccagat cattctcagc 360
ttcccaggca gacccactca gtgatcctga tcagatgaac gaggacaagc gccattcaca 420
gggcacattc accagtgact acagcaagta tctggactcc aggcgtgccc aagattttgt 480
gcagtggttg atgaatacca agaggaacag gaataacatt gccaaacgtc acgatgaatt 540
tgagagacat gctgaaggga cctttaccag tgatgtaagt tcttatttgg aaggccaagc 600
tgccaaggaa ttcattgctt ggctggtgaa aggccgagga aggcgagatt tcccagaaga 660
ggtcgccatt gttgaagaac ttggccgcag acatgctgat ggttctttct ctgatgagat 720
gaacaccatt cttgataatc ttgccgccag ggactttata aactggttga ttcagaccaa 780
aatcactgac aggaaataac tatatcacta ttcaagatca tcttcacaac atcacctgct 840
agccacgtgg gatgtttgaa atgttaagtc ctgtaaattt aagaggtgta ttctgaggcc 900
acattgcttt gcatgccaat aaataaattt tcttttagtg ttgtgtagcc aaaaattaca 960
aatggaataa agttttatca aaatattgct aaaatatcag ctttaaaata tgaaagtgct 1020
agattctgtt attttcttct tattttggat gaagtacccc aacctgttta catttagcga 1080
taaaattatt tttctatgat ataatttgta aatgtaaatt attccgatct gacatatctg 1140
cattataata ataggagaat agaagaactg gtagccacag tggtgaaatt ggaaagagaa 1200
ctttcttcct gaaacctttg tcttaaaaat actcagcttt caatgtatca aagatacaat 1260
taaataaaat tttcaagctt ctttaccaaa aaaaaaaa                         1298

<210> 7
<211> 39
<212> PRT
<213> Homo sapiens

<400> 7
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser
            20                  25                  30          
Ser Gly Ala Pro Pro Pro Ser
        35                  


<210> 8
<211> 15
<212> DNA
<213> Homo sapiens

<400> 8
ggggsggggs ggggs                                                  15

<210> 9
<211> 216
<212> PRT
<213> Homo sapiens

<400> 9
His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Glu Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
His Gln Ser Pro Glu Ser Leu Leu Glu Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Lys
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Arg Ser Pro His
145                 150                 155                 160 
Cys Asp Pro Ala Pro Gln Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ala Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 10
<211> 651
<212> DNA
<213> Homo sapiens

<400> 10
cattctgaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgaaa 60
gaattcatcg cgtggctggt taaaggcggt tctggtggtg gtggttctgg cggtggcgat 120
agcagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcaggaaa ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
catcagagcc cggaaagcct gctggaactg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagaaaccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaaccg tagcccgcat 480
tgcgatccgg caccgcaggg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctggcgatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 11
<211> 227
<212> PRT
<213> Homo sapiens

<400> 11
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
        35                  40                  45              
Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln
    50                  55                  60                  
Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Glu Thr Glu Ala His Leu Glu
65                  70                  75                  80  
Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala His Gln Ser Pro Glu
                85                  90                  95      
Ser Leu Leu Glu Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu
            100                 105                 110         
Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Lys Pro Asp Gly Ala Leu
        115                 120                 125             
Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu
    130                 135                 140                 
Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu
145                 150                 155                 160 
Pro Leu His Leu Pro Gly Asn Arg Ser Pro His Cys Asp Pro Ala Pro
                165                 170                 175     
Gln Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu
            180                 185                 190         
Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser
        195                 200                 205             
Ser Asp Pro Leu Ala Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser
    210                 215                 220                 
Tyr Ala Ser
225         


<210> 12
<211> 684
<212> DNA
<213> Homo sapiens

<400> 12
catggtgagg gtacgtttac ttctgatctg tctaaacaga tggaagaaga agctgttcgc 60
ctgttcattg aatggctgaa aaatggtggt tctggtggtg gtggttctgg cggtggcggt 120
tctggcggcg gtggtagcgg tggcggcggt gatagcagcc cgctgctgca gtttggcggc 180
caggtgcgtc agcgttatct gtataccgat gatgcgcagg aaaccgaagc gcatctggaa 240
attcgtgaag atggcaccgt gggcggtgcg gcgcatcaga gcccggaaag cctgctggaa 300
ctgaaagcgc tgaaaccggg cgtgattcag attctgggcg tgaaaaccag ccgttttctg 360
tgccagaaac cggatggcgc gctgtatggc agcctgcatt ttgatccgga agcgtgcagc 420
tttcgtgaac tgctgctgga agatggctat aacgtgtatc agagcgaagc gcatggcctg 480
ccgctgcatc tgccgggcaa ccgtagcccg cattgcgatc cggcaccgca gggtccggcg 540
cgttttctgc cgctgccggg tctgccgccg gcactgccgg aaccgccggg tattctggcc 600
ccgcagccgc cggatgttgg tagcagcgat ccgctggcga tggtgggtcc gagccagggt 660
cgtagcccga gctatgcgag ctaa                                        684

<210> 13
<211> 209
<212> PRT
<213> Homo sapiens

<400> 13
His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Ser Gly
            20                  25                  30          
Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr
        35                  40                  45              
Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg
    50                  55                  60                  
Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu
65                  70                  75                  80  
Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val
                85                  90                  95      
Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly
            100                 105                 110         
Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu
        115                 120                 125             
Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu
    130                 135                 140                 
His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly
145                 150                 155                 160 
Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu
                165                 170                 175     
Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp
            180                 185                 190         
Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala
        195                 200                 205             
Ser
    


<210> 14
<211> 630
<212> DNA
<213> Homo sapiens

<400> 14
cattctgaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgaaa 60
gaattcatcg cgtggctggt taaaggcggt tctggtgata gcagcccgct gctgcagttt 120
ggcggccagg tgcgtcagcg ttatctgtat accgatgatg cgcagcagac cgaagcgcat 180
ctggaaattc gtgaagatgg caccgtgggc ggtgcggcgg atcagagccc ggaaagcctg 240
ctgcagctga aagcgctgaa accgggcgtg attcagattc tgggcgtgaa aaccagccgt 300
tttctgtgcc agcgtccgga tggcgcgctg tatggcagcc tgcattttga tccggaagcg 360
tgcagctttc gtgaactgct gctggaagat ggctataacg tgtatcagag cgaagcgcat 420
ggcctgccgc tgcatctgcc gggcaacaaa agcccgcatc gtgatccggc accgcgtggt 480
ccggcgcgtt ttctgccgct gccgggtctg ccgccggcac tgccggaacc gccgggtatt 540
ctggccccgc agccgccgga tgttggtagc agcgatccgc tgtctatggt gggtccgagc 600
cagggtcgta gcccgagcta tgcgagctaa                                  630

<210> 15
<211> 209
<212> PRT
<213> Homo sapiens

<400> 15
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Ser Gly
            20                  25                  30          
Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr
        35                  40                  45              
Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg
    50                  55                  60                  
Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu
65                  70                  75                  80  
Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val
                85                  90                  95      
Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly
            100                 105                 110         
Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu
        115                 120                 125             
Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu
    130                 135                 140                 
His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly
145                 150                 155                 160 
Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu
                165                 170                 175     
Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp
            180                 185                 190         
Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala
        195                 200                 205             
Ser
    


<210> 16
<211> 630
<212> DNA
<213> Homo sapiens

<400> 16
catgcggaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgaaa 60
gaattcatcg cgtggctggt taaaggcggt tctggtgata gcagcccgct gctgcagttt 120
ggcggccagg tgcgtcagcg ttatctgtat accgatgatg cgcagcagac cgaagcgcat 180
ctggaaattc gtgaagatgg caccgtgggc ggtgcggcgg atcagagccc ggaaagcctg 240
ctgcagctga aagcgctgaa accgggcgtg attcagattc tgggcgtgaa aaccagccgt 300
tttctgtgcc agcgtccgga tggcgcgctg tatggcagcc tgcattttga tccggaagcg 360
tgcagctttc gtgaactgct gctggaagat ggctataacg tgtatcagag cgaagcgcat 420
ggcctgccgc tgcatctgcc gggcaacaaa agcccgcatc gtgatccggc accgcgtggt 480
ccggcgcgtt ttctgccgct gccgggtctg ccgccggcac tgccggaacc gccgggtatt 540
ctggccccgc agccgccgga tgttggtagc agcgatccgc tgtctatggt gggtccgagc 600
cagggtcgta gcccgagcta tgcgagctaa                                  630

<210> 17
<211> 219
<212> PRT
<213> Homo sapiens

<400> 17
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser
            20                  25                  30          
Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu
        35                  40                  45              
Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala
    50                  55                  60                  
Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly
65                  70                  75                  80  
Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu
                85                  90                  95      
Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu
            100                 105                 110         
Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro
        115                 120                 125             
Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val
    130                 135                 140                 
Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys
145                 150                 155                 160 
Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro
                165                 170                 175     
Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala
            180                 185                 190         
Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly
        195                 200                 205             
Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215                 


<210> 18
<211> 660
<212> DNA
<213> Homo sapiens

<400> 18
catggtgagg gtacgtttac ttctgatctg tctaaacaga tggaagaaga agctgttcgc 60
ctgttcattg aatggctgaa aaatggtggt ccgtcctccg gcgctcctcc gccttctggt 120
ggtggcgact cgagcccgct gctgcagttt ggcggccagg tgcgtcagcg ttatctgtat 180
accgatgatg cgcagcagac cgaagcgcat ctggaaattc gtgaagatgg caccgtgggc 240
ggtgcggcgg atcagagccc ggaaagcctg ctgcagctga aagcgctgaa accgggcgtg 300
attcagattc tgggcgtgaa aaccagccgt tttctgtgcc agcgtccgga tggcgcgctg 360
tatggcagcc tgcattttga tccggaagcg tgcagctttc gtgaactgct gctggaagat 420
ggctataacg tgtatcagag cgaagcgcat ggcctgccgc tgcatctgcc gggcaacaaa 480
agcccgcatc gtgatccggc accgcgtggt ccggcgcgtt ttctgccgct gccgggtctg 540
ccgccggcac tgccggaacc gccgggtatt ctggccccgc agccgccgga tgttggtagc 600
agcgatccgc tgtctatggt gggtccgagc cagggtcgta gcccgagcta tgcgagctaa 660


<210> 19
<211> 216
<212> PRT
<213> Homo sapiens

<400> 19
His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His
145                 150                 155                 160 
Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 20
<211> 651
<212> DNA
<213> Homo sapiens

<400> 20
cattctgaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgaaa 60
gaattcatcg cgtggctggt taaaggcggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcagcaga ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
gatcagagcc cggaaagcct gctgcagctg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagcgtccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaacaa aagcccgcat 480
cgtgatccgg caccgcgtgg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctgtctatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 21
<211> 216
<212> PRT
<213> Homo sapiens

<400> 21
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His
145                 150                 155                 160 
Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 22
<211> 651
<212> DNA
<213> Homo sapiens

<400> 22
catgcggaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgaaa 60
gaattcatcg cgtggctggt taaaggcggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcagcaga ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
gatcagagcc cggaaagcct gctgcagctg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagcgtccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaacaa aagcccgcat 480
cgtgatccgg caccgcgtgg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctgtctatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 23
<211> 224
<212> PRT
<213> Homo sapiens

<400> 23
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser
            20                  25                  30          
Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Asp
        35                  40                  45              
Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu
    50                  55                  60                  
Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu
65                  70                  75                  80  
Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu
                85                  90                  95      
Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys
            100                 105                 110         
Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser
        115                 120                 125             
Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu
    130                 135                 140                 
Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His
145                 150                 155                 160 
Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro
                165                 170                 175     
Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu Pro
            180                 185                 190         
Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro
        195                 200                 205             
Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215                 220                 


<210> 24
<211> 675
<212> DNA
<213> Homo sapiens

<400> 24
catggtgagg gtacgtttac ttctgatctg tctaaacaga tggaagaaga agctgttcgc 60
ctgttcattg aatggctgaa aaatggtggt ccgtcctccg gcgctcctcc gccttctggt 120
ggtggtggtt ctggcggtgg cgactcgagc ccgctgctgc agtttggcgg ccaggtgcgt 180
cagcgttatc tgtataccga tgatgcgcag cagaccgaag cgcatctgga aattcgtgaa 240
gatggcaccg tgggcggtgc ggcggatcag agcccggaaa gcctgctgca gctgaaagcg 300
ctgaaaccgg gcgtgattca gattctgggc gtgaaaacca gccgttttct gtgccagcgt 360
ccggatggcg cgctgtatgg cagcctgcat tttgatccgg aagcgtgcag ctttcgtgaa 420
ctgctgctgg aagatggcta taacgtgtat cagagcgaag cgcatggcct gccgctgcat 480
ctgccgggca acaaaagccc gcatcgtgat ccggcaccgc gtggtccggc gcgttttctg 540
ccgctgccgg gtctgccgcc ggcactgccg gaaccgccgg gtattctggc cccgcagccg 600
ccggatgttg gtagcagcga tccgctgtct atggtgggtc cgagccaggg tcgtagcccg 660
agctatgcga gctaa                                                  675

<210> 25
<211> 486
<212> PRT
<213> Homo sapiens

<400> 25
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser
            20                  25                  30          
Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys
        35                  40                  45              
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
    50                  55                  60                  
Gly Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
65                  70                  75                  80  
Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
                85                  90                  95      
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
            100                 105                 110         
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
        115                 120                 125             
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
    130                 135                 140                 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
145                 150                 155                 160 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
                165                 170                 175     
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
            180                 185                 190         
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
        195                 200                 205             
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
    210                 215                 220                 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
225                 230                 235                 240 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
                245                 250                 255     
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
            260                 265                 270         
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
        275                 280                 285             
Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
    290                 295                 300                 
Gly Gly Gly Gly Ser Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln
305                 310                 315                 320 
Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr Glu Ala
                325                 330                 335     
His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln
            340                 345                 350         
Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile
        355                 360                 365             
Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Lys Pro Asp
    370                 375                 380                 
Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe
385                 390                 395                 400 
Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala
                405                 410                 415     
His Gly Leu Pro Leu His Leu Pro Cys Asn Arg Ser Pro His Arg Asp
            420                 425                 430         
Pro Ala Ser Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro
        435                 440                 445             
Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp
    450                 455                 460                 
Val Gly Ser Ser Asp Pro Leu Ala Met Val Gly Gly Ser Gln Ala Arg
465                 470                 475                 480 
Ser Pro Ser Tyr Ala Ser
                485     


<210> 26
<211> 486
<212> PRT
<213> Homo sapiens

<400> 26
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser
            20                  25                  30          
Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys
        35                  40                  45              
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
    50                  55                  60                  
Gly Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
65                  70                  75                  80  
Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
                85                  90                  95      
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
            100                 105                 110         
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
        115                 120                 125             
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
    130                 135                 140                 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
145                 150                 155                 160 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
                165                 170                 175     
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
            180                 185                 190         
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
        195                 200                 205             
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
    210                 215                 220                 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
225                 230                 235                 240 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
                245                 250                 255     
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
            260                 265                 270         
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
        275                 280                 285             
Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
    290                 295                 300                 
Gly Gly Gly Gly Ser Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln
305                 310                 315                 320 
Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr Glu Ala
                325                 330                 335     
His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln
            340                 345                 350         
Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile
        355                 360                 365             
Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Lys Pro Asp
    370                 375                 380                 
Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe
385                 390                 395                 400 
Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala
                405                 410                 415     
His Gly Leu Pro Leu His Leu Pro Cys Asn Arg Ser Pro His Arg Asp
            420                 425                 430         
Pro Ala Ser Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro
        435                 440                 445             
Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp
    450                 455                 460                 
Val Gly Ser Ser Asp Pro Leu Ala Met Val Gly Pro Ser Gln Ala Arg
465                 470                 475                 480 
Ser Pro Ser Tyr Glu Ser
                485     


<210> 27
<211> 486
<212> PRT
<213> Homo sapiens

<400> 27
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser
            20                  25                  30          
Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys
        35                  40                  45              
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
    50                  55                  60                  
Gly Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
65                  70                  75                  80  
Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
                85                  90                  95      
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
            100                 105                 110         
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
        115                 120                 125             
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
    130                 135                 140                 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
145                 150                 155                 160 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
                165                 170                 175     
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
            180                 185                 190         
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
        195                 200                 205             
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
    210                 215                 220                 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
225                 230                 235                 240 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
                245                 250                 255     
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
            260                 265                 270         
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
        275                 280                 285             
Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
    290                 295                 300                 
Gly Gly Gly Gly Ser Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln
305                 310                 315                 320 
Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr Glu Ala
                325                 330                 335     
His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln
            340                 345                 350         
Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile
        355                 360                 365             
Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Lys Pro Asp
    370                 375                 380                 
Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe
385                 390                 395                 400 
Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala
                405                 410                 415     
His Gly Leu Pro Leu His Leu Pro Cys Asn Arg Ser Pro His Arg Asp
            420                 425                 430         
Pro Ala Ser Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro
        435                 440                 445             
Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp
    450                 455                 460                 
Val Gly Ser Ser Asp Pro Leu Ala Met Val Gly Pro Ser Gln Ala Arg
465                 470                 475                 480 
Ser Pro Ser Tyr Asp Ser
                485     


<210> 28
<211> 216
<212> PRT
<213> Homo sapiens

<400> 28
His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Glu Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
His Gln Ser Pro Glu Ser Leu Leu Glu Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Lys
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Arg Ser Pro His
145                 150                 155                 160 
Cys Asp Pro Ala Pro Gln Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ala Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 29
<211> 651
<212> DNA
<213> Homo sapiens

<400> 29
catggtgaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgaaa 60
gaattcatcg cgtggctggt taaaggcggt tctggtggtg gtggttctgg cggtggcgat 120
agcagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcaggaaa ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
catcagagcc cggaaagcct gctggaactg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagaaaccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaaccg tagcccgcat 480
tgcgatccgg caccgcaggg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctggcgatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 30
<211> 216
<212> PRT
<213> Homo sapiens

<400> 30
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Gly
 1               5                  10                  15      
Gln Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Glu Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
His Gln Ser Pro Glu Ser Leu Leu Glu Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Lys
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Arg Ser Pro His
145                 150                 155                 160 
Cys Asp Pro Ala Pro Gln Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ala Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 31
<211> 651
<212> DNA
<213> Homo sapiens

<400> 31
catggtgagg gtacgtttac ttctgatctg tctaaacaga tggaagggca agctgttcgc 60
ctgttcattg aatggctgaa aaatggtggt tctggtggtg gtggttctgg cggtggcgat 120
agcagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcaggaaa ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
catcagagcc cggaaagcct gctggaactg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagaaaccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaaccg tagcccgcat 480
tgcgatccgg caccgcaggg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctggcgatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 32
<211> 216
<212> PRT
<213> Homo sapiens

<400> 32
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Glu Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
His Gln Ser Pro Glu Ser Leu Leu Glu Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Lys
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Arg Ser Pro His
145                 150                 155                 160 
Cys Asp Pro Ala Pro Gln Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ala Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 33
<211> 651
<212> DNA
<213> Homo sapiens

<400> 33
catggtgagg gtacgtttac ttctgatctg tctaaacaga tggaagaaga agctgttcgc 60
ctgttcattg aatggctgaa aaatggtggt tctggtggtg gtggttctgg cggtggcgat 120
agcagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcaggaaa ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
catcagagcc cggaaagcct gctggaactg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagaaaccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaaccg tagcccgcat 480
tgcgatccgg caccgcaggg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctggcgatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 34
<211> 216
<212> PRT
<213> Homo sapiens

<220> 
<223> Non-natural amino acid

<400> 34
His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His
145                 150                 155                 160 
Xaa Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 35
<211> 651
<212> DNA
<213> Homo sapiens

<400> 35
cattctgaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgaaa 60
gaattcatcg cgtggctggt taaaggcggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcagcaga ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
gatcagagcc cggaaagcct gctgcagctg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagcgtccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaacaa aagcccgcat 480
taggatccgg caccgcgtgg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctgtctatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 36
<211> 216
<212> PRT
<213> Homo sapiens

<220> 
<223> Non-natural amino acid

<400> 36
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His
145                 150                 155                 160 
Xaa Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 37
<211> 651
<212> DNA
<213> Homo sapiens

<400> 37
catgcggaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgaaa 60
gaattcatcg cgtggctggt taaaggcggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcagcaga ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
gatcagagcc cggaaagcct gctgcagctg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagcgtccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaacaa aagcccgcat 480
taggatccgg caccgcgtgg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctgtctatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 38
<211> 224
<212> PRT
<213> Homo sapiens

<220> 
<223> Non-natural amino acid

<400> 38
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser
            20                  25                  30          
Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Asp
        35                  40                  45              
Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu
    50                  55                  60                  
Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu
65                  70                  75                  80  
Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu
                85                  90                  95      
Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys
            100                 105                 110         
Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser
        115                 120                 125             
Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu
    130                 135                 140                 
Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His
145                 150                 155                 160 
Leu Pro Gly Asn Lys Ser Pro His Xaa Asp Pro Ala Pro Arg Gly Pro
                165                 170                 175     
Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu Pro
            180                 185                 190         
Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro
        195                 200                 205             
Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215                 220                 


<210> 39
<211> 675
<212> DNA
<213> Homo sapiens

<400> 39
catggtgagg gtacgtttac ttctgatctg tctaaacaga tggaagaaga agctgttcgc 60
ctgttcattg aatggctgaa aaatggtggt ccgtcctccg gcgctcctcc gccttctggt 120
ggtggtggtt ctggcggtgg cgactcgagc ccgctgctgc agtttggcgg ccaggtgcgt 180
cagcgttatc tgtataccga tgatgcgcag cagaccgaag cgcatctgga aattcgtgaa 240
gatggcaccg tgggcggtgc ggcggatcag agcccggaaa gcctgctgca gctgaaagcg 300
ctgaaaccgg gcgtgattca gattctgggc gtgaaaacca gccgttttct gtgccagcgt 360
ccggatggcg cgctgtatgg cagcctgcat tttgatccgg aagcgtgcag ctttcgtgaa 420
ctgctgctgg aagatggcta taacgtgtat cagagcgaag cgcatggcct gccgctgcat 480
ctgccgggca acaaaagccc gcattaggat ccggcaccgc gtggtccggc gcgttttctg 540
ccgctgccgg gtctgccgcc ggcactgccg gaaccgccgg gtattctggc cccgcagccg 600
ccggatgttg gtagcagcga tccgctgtct atggtgggtc cgagccaggg tcgtagcccg 660
agctatgcga gctaa                                                  675

<210> 40
<211> 216
<212> PRT
<213> Homo sapiens

<400> 40
His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His
145                 150                 155                 160 
Cys Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 41
<211> 651
<212> DNA
<213> Homo sapiens

<400> 41
cattctgaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgaaa 60
gaattcatcg cgtggctggt taaaggcggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcagcaga ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
gatcagagcc cggaaagcct gctgcagctg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagcgtccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaacaa aagcccgcat 480
tgcgatccgg caccgcgtgg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctgtctatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 42
<211> 216
<212> PRT
<213> Homo sapiens

<400> 42
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His
145                 150                 155                 160 
Cys Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 43
<211> 651
<212> DNA
<213> Homo sapiens

<400> 43
catgcggaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgaaa 60
gaattcatcg cgtggctggt taaaggcggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcagcaga ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
gatcagagcc cggaaagcct gctgcagctg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagcgtccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaacaa aagcccgcat 480
tgcgatccgg caccgcgtgg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctgtctatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 44
<211> 224
<212> PRT
<213> Homo sapiens

<400> 44
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser
            20                  25                  30          
Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Asp
        35                  40                  45              
Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu
    50                  55                  60                  
Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu
65                  70                  75                  80  
Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu
                85                  90                  95      
Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys
            100                 105                 110         
Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser
        115                 120                 125             
Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu
    130                 135                 140                 
Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His
145                 150                 155                 160 
Leu Pro Gly Asn Lys Ser Pro His Cys Asp Pro Ala Pro Arg Gly Pro
                165                 170                 175     
Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu Pro
            180                 185                 190         
Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro
        195                 200                 205             
Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215                 220                 


<210> 45
<211> 675
<212> DNA
<213> Homo sapiens

<400> 45
catggtgagg gtacgtttac ttctgatctg tctaaacaga tggaagaaga agctgttcgc 60
ctgttcattg aatggctgaa aaatggtggt ccgtcctccg gcgctcctcc gccttctggt 120
ggtggtggtt ctggcggtgg cgactcgagc ccgctgctgc agtttggcgg ccaggtgcgt 180
cagcgttatc tgtataccga tgatgcgcag cagaccgaag cgcatctgga aattcgtgaa 240
gatggcaccg tgggcggtgc ggcggatcag agcccggaaa gcctgctgca gctgaaagcg 300
ctgaaaccgg gcgtgattca gattctgggc gtgaaaacca gccgttttct gtgccagcgt 360
ccggatggcg cgctgtatgg cagcctgcat tttgatccgg aagcgtgcag ctttcgtgaa 420
ctgctgctgg aagatggcta taacgtgtat cagagcgaag cgcatggcct gccgctgcat 480
ctgccgggca acaaaagccc gcattgcgat ccggcaccgc gtggtccggc gcgttttctg 540
ccgctgccgg gtctgccgcc ggcactgccg gaaccgccgg gtattctggc cccgcagccg 600
ccggatgttg gtagcagcga tccgctgtct atggtgggtc cgagccaggg tcgtagcccg 660
agctatgcga gctaa                                                  675

<210> 46
<211> 216
<212> PRT
<213> Homo sapiens

<400> 46
His Ala Pro Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His
145                 150                 155                 160 
Cys Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 47
<211> 651
<212> DNA
<213> Homo sapiens

<400> 47
catgcgccgg gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgaaa 60
gaattcatcg cgtggctggt taaaggcggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcagcaga ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
gatcagagcc cggaaagcct gctgcagctg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagcgtccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaacaa aagcccgcat 480
tgcgatccgg caccgcgtgg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctgtctatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 48
<211> 217
<212> PRT
<213> Homo sapiens

<400> 48
Gly His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu
 1               5                  10                  15      
Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Ser
            20                  25                  30          
Gly Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe
        35                  40                  45              
Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln
    50                  55                  60                  
Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala
65                  70                  75                  80  
Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro
                85                  90                  95      
Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln
            100                 105                 110         
Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala
        115                 120                 125             
Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln
    130                 135                 140                 
Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro
145                 150                 155                 160 
His Cys Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro
                165                 170                 175     
Gly Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln
            180                 185                 190         
Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser
        195                 200                 205             
Gln Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215         


<210> 49
<211> 654
<212> DNA
<213> Homo sapiens

<400> 49
ggtcatgcgg aaggcacttt tactagcgat gtttctagct acctggaagg ccaggctgcg 60
aaagaattca tcgcgtggct ggttaaaggc ggttctggtg gtggtggttc tggcggtggc 120
gactcgagcc cgctgctgca gtttggcggc caggtgcgtc agcgttatct gtataccgat 180
gatgcgcagc agaccgaagc gcatctggaa attcgtgaag atggcaccgt gggcggtgcg 240
gcggatcaga gcccggaaag cctgctgcag ctgaaagcgc tgaaaccggg cgtgattcag 300
attctgggcg tgaaaaccag ccgttttctg tgccagcgtc cggatggcgc gctgtatggc 360
agcctgcatt ttgatccgga agcgtgcagc tttcgtgaac tgctgctgga agatggctat 420
aacgtgtatc agagcgaagc gcatggcctg ccgctgcatc tgccgggcaa caaaagcccg 480
cattgcgatc cggcaccgcg tggtccggcg cgttttctgc cgctgccggg tctgccgccg 540
gcactgccgg aaccgccggg tattctggcc ccgcagccgc cggatgttgg tagcagcgat 600
ccgctgtcta tggtgggtcc gagccagggt cgtagcccga gctatgcgag ctaa       654

<210> 50
<211> 216
<212> PRT
<213> Homo sapiens

<400> 50
His Ser Glu Gly Thr Phe Thr Ala Asp Ala Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His
145                 150                 155                 160 
Cys Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 51
<211> 651
<212> DNA
<213> Homo sapiens

<400> 51
cattctgaag gcacttttac tgctgatgct tctagctacc tggaaggcca ggctgcgaaa 60
gaattcatcg cgtggctggt taaaggcggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcagcaga ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
gatcagagcc cggaaagcct gctgcagctg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagcgtccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaacaa aagcccgcat 480
tgcgatccgg caccgcgtgg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctgtctatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 52
<211> 216
<212> PRT
<213> Homo sapiens

<400> 52
His Ser Glu Gly Thr Phe Thr Ser Asp Ala Ala Ala Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His
145                 150                 155                 160 
Cys Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 53
<211> 651
<212> DNA
<213> Homo sapiens

<400> 53
cattctgaag gcacttttac tagcgatgct gctgcttacc tggaaggcca ggctgcgaaa 60
gaattcatcg cgtggctggt taaaggcggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcagcaga ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
gatcagagcc cggaaagcct gctgcagctg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagcgtccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaacaa aagcccgcat 480
tgcgatccgg caccgcgtgg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctgtctatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 54
<211> 216
<212> PRT
<213> Homo sapiens

<400> 54
His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Ala Glu Gly
 1               5                  10                  15      
Ala Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His
145                 150                 155                 160 
Cys Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 55
<211> 651
<212> DNA
<213> Homo sapiens

<400> 55
cattctgaag gcacttttac tagcgatgtt tctagctacg ctgaaggcgc tgctgcgaaa 60
gaattcatcg cgtggctggt taaaggcggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcagcaga ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
gatcagagcc cggaaagcct gctgcagctg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagcgtccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaacaa aagcccgcat 480
tgcgatccgg caccgcgtgg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctgtctatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 56
<211> 216
<212> PRT
<213> Homo sapiens

<400> 56
His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Ala Ile Ala Ala Leu Val Lys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His
145                 150                 155                 160 
Cys Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 57
<211> 651
<212> DNA
<213> Homo sapiens

<400> 57
cattctgaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgaaa 60
gaagctatcg cggctctggt taaaggcggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcagcaga ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
gatcagagcc cggaaagcct gctgcagctg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagcgtccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaacaa aagcccgcat 480
tgcgatccgg caccgcgtgg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctgtctatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 58
<211> 185
<212> PRT
<213> Homo sapiens

<400> 58
His Ser Glu Gly Thr Phe Thr Ser Asp Ser Ser Pro Leu Leu Gln Phe
 1               5                  10                  15      
Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln
            20                  25                  30          
Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala
        35                  40                  45              
Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro
    50                  55                  60                  
Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln
65                  70                  75                  80  
Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala
                85                  90                  95      
Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln
            100                 105                 110         
Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro
        115                 120                 125             
His Cys Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro
    130                 135                 140                 
Gly Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln
145                 150                 155                 160 
Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser
                165                 170                 175     
Gln Gly Arg Ser Pro Ser Tyr Ala Ser
            180                 185 


<210> 59
<211> 558
<212> DNA
<213> Homo sapiens

<400> 59
cattctgaag gcacttttac tagcgatagc agcccgctgc tgcagtttgg cggccaggtg 60
cgtcagcgtt atctgtatac cgatgatgcg cagcagaccg aagcgcatct ggaaattcgt 120
gaagatggca ccgtgggcgg tgcggcggat cagagcccgg aaagcctgct gcagctgaaa 180
gcgctgaaac cgggcgtgat tcagattctg ggcgtgaaaa ccagccgttt tctgtgccag 240
cgtccggatg gcgcgctgta tggcagcctg cattttgatc cggaagcgtg cagctttcgt 300
gaactgctgc tggaagatgg ctataacgtg tatcagagcg aagcgcatgg cctgccgctg 360
catctgccgg gcaacaaaag cccgcattgc gatccggcac cgcgtggtcc ggcgcgtttt 420
ctgccgctgc cgggtctgcc gccggcactg ccggaaccgc cgggtattct ggccccgcag 480
ccgccggatg ttggtagcag cgatccgctg tctatggtgg gtccgagcca gggtcgtagc 540
ccgagctatg cgagctaa                                               558

<210> 60
<211> 197
<212> PRT
<213> Homo sapiens

<400> 60
His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Gly Gly Gly Gly
 1               5                  10                  15      
Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val
            20                  25                  30          
Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His
        35                  40                  45              
Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser
    50                  55                  60                  
Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln
65                  70                  75                  80  
Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly
                85                  90                  95      
Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg
            100                 105                 110         
Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His
        115                 120                 125             
Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Cys Asp Pro
    130                 135                 140                 
Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro
145                 150                 155                 160 
Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val
                165                 170                 175     
Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser
            180                 185                 190         
Pro Ser Tyr Ala Ser
        195         


<210> 61
<211> 594
<212> DNA
<213> Homo sapiens

<400> 61
cattctgaag gcacttttac tagcgatgtt tcttctggtg gtggtggttc tggcggtggc 60
gactcgagcc cgctgctgca gtttggcggc caggtgcgtc agcgttatct gtataccgat 120
gatgcgcagc agaccgaagc gcatctggaa attcgtgaag atggcaccgt gggcggtgcg 180
gcggatcaga gcccggaaag cctgctgcag ctgaaagcgc tgaaaccggg cgtgattcag 240
attctgggcg tgaaaaccag ccgttttctg tgccagcgtc cggatggcgc gctgtatggc 300
agcctgcatt ttgatccgga agcgtgcagc tttcgtgaac tgctgctgga agatggctat 360
aacgtgtatc agagcgaagc gcatggcctg ccgctgcatc tgccgggcaa caaaagcccg 420
cattgcgatc cggcaccgcg tggtccggcg cgttttctgc cgctgccggg tctgccgccg 480
gcactgccgg aaccgccggg tattctggcc ccgcagccgc cggatgttgg tagcagcgat 540
ccgctgtcta tggtgggtcc gagccagggt cgtagcccga gctatgcgag ctaa       594

<210> 62
<211> 201
<212> PRT
<213> Homo sapiens

<400> 62
His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Ser
 1               5                  10                  15      
Gly Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe
            20                  25                  30          
Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln
        35                  40                  45              
Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala
    50                  55                  60                  
Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro
65                  70                  75                  80  
Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln
                85                  90                  95      
Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala
            100                 105                 110         
Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln
        115                 120                 125             
Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro
    130                 135                 140                 
His Cys Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro
145                 150                 155                 160 
Gly Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln
                165                 170                 175     
Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser
            180                 185                 190         
Gln Gly Arg Ser Pro Ser Tyr Ala Ser
        195                 200     


<210> 63
<211> 606
<212> DNA
<213> Homo sapiens

<400> 63
cattctgaag gcacttttac tagcgatgtt tctagctacc tggaatctgg tggtggtggt 60
tctggcggtg gcgactcgag cccgctgctg cagtttggcg gccaggtgcg tcagcgttat 120
ctgtataccg atgatgcgca gcagaccgaa gcgcatctgg aaattcgtga agatggcacc 180
gtgggcggtg cggcggatca gagcccggaa agcctgctgc agctgaaagc gctgaaaccg 240
ggcgtgattc agattctggg cgtgaaaacc agccgttttc tgtgccagcg tccggatggc 300
gcgctgtatg gcagcctgca ttttgatccg gaagcgtgca gctttcgtga actgctgctg 360
gaagatggct ataacgtgta tcagagcgaa gcgcatggcc tgccgctgca tctgccgggc 420
aacaaaagcc cgcattgcga tccggcaccg cgtggtccgg cgcgttttct gccgctgccg 480
ggtctgccgc cggcactgcc ggaaccgccg ggtattctgg ccccgcagcc gccggatgtt 540
ggtagcagcg atccgctgtc tatggtgggt ccgagccagg gtcgtagccc gagctatgcg 600
agctaa                                                            606

<210> 64
<211> 197
<212> PRT
<213> Homo sapiens

<400> 64
His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val
            20                  25                  30          
Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His
        35                  40                  45              
Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser
    50                  55                  60                  
Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln
65                  70                  75                  80  
Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly
                85                  90                  95      
Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg
            100                 105                 110         
Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His
        115                 120                 125             
Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Cys Asp Pro
    130                 135                 140                 
Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro
145                 150                 155                 160 
Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val
                165                 170                 175     
Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser
            180                 185                 190         
Pro Ser Tyr Ala Ser
        195         


<210> 65
<211> 594
<212> DNA
<213> Homo sapiens

<400> 65
cattctgaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgaaa 60
gatagcagcc cgctgctgca gtttggcggc caggtgcgtc agcgttatct gtataccgat 120
gatgcgcagc agaccgaagc gcatctggaa attcgtgaag atggcaccgt gggcggtgcg 180
gcggatcaga gcccggaaag cctgctgcag ctgaaagcgc tgaaaccggg cgtgattcag 240
attctgggcg tgaaaaccag ccgttttctg tgccagcgtc cggatggcgc gctgtatggc 300
agcctgcatt ttgatccgga agcgtgcagc tttcgtgaac tgctgctgga agatggctat 360
aacgtgtatc agagcgaagc gcatggcctg ccgctgcatc tgccgggcaa caaaagcccg 420
cattgcgatc cggcaccgcg tggtccggcg cgttttctgc cgctgccggg tctgccgccg 480
gcactgccgg aaccgccggg tattctggcc ccgcagccgc cggatgttgg tagcagcgat 540
ccgctgtcta tggtgggtcc gagccagggt cgtagcccga gctatgcgag ctaa       594

<210> 66
<211> 209
<212> PRT
<213> Homo sapiens

<400> 66
His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ser Gly Gly Gly Gly Ser Gly Gly Gly
            20                  25                  30          
Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr
        35                  40                  45              
Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg
    50                  55                  60                  
Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu
65                  70                  75                  80  
Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val
                85                  90                  95      
Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly
            100                 105                 110         
Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu
        115                 120                 125             
Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu
    130                 135                 140                 
His Leu Pro Gly Asn Lys Ser Pro His Cys Asp Pro Ala Pro Arg Gly
145                 150                 155                 160 
Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu
                165                 170                 175     
Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp
            180                 185                 190         
Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala
        195                 200                 205             
Ser
    


<210> 67
<211> 630
<212> DNA
<213> Homo sapiens

<400> 67
cattctgaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgaaa 60
gaattcatct ctggtggtgg tggttctggc ggtggcgact cgagcccgct gctgcagttt 120
ggcggccagg tgcgtcagcg ttatctgtat accgatgatg cgcagcagac cgaagcgcat 180
ctggaaattc gtgaagatgg caccgtgggc ggtgcggcgg atcagagccc ggaaagcctg 240
ctgcagctga aagcgctgaa accgggcgtg attcagattc tgggcgtgaa aaccagccgt 300
tttctgtgcc agcgtccgga tggcgcgctg tatggcagcc tgcattttga tccggaagcg 360
tgcagctttc gtgaactgct gctggaagat ggctataacg tgtatcagag cgaagcgcat 420
ggcctgccgc tgcatctgcc gggcaacaaa agcccgcatt gcgatccggc accgcgtggt 480
ccggcgcgtt ttctgccgct gccgggtctg ccgccggcac tgccggaacc gccgggtatt 540
ctggccccgc agccgccgga tgttggtagc agcgatccgc tgtctatggt gggtccgagc 600
cagggtcgta gcccgagcta tgcgagctaa                                  630

<210> 68
<211> 212
<212> PRT
<213> Homo sapiens

<400> 68
His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Ser Gly Gly Gly Gly Ser
            20                  25                  30          
Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg
        35                  40                  45              
Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu
    50                  55                  60                  
Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro
65                  70                  75                  80  
Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile
                85                  90                  95      
Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala
            100                 105                 110         
Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu
        115                 120                 125             
Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly
    130                 135                 140                 
Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Cys Asp Pro Ala
145                 150                 155                 160 
Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala
                165                 170                 175     
Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly
            180                 185                 190         
Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro
        195                 200                 205             
Ser Tyr Ala Ser
    210         


<210> 69
<211> 639
<212> DNA
<213> Homo sapiens

<400> 69
cattctgaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgaaa 60
gaattcatcg cgtggctgtc tggtggtggt ggttctggcg gtggcgactc gagcccgctg 120
ctgcagtttg gcggccaggt gcgtcagcgt tatctgtata ccgatgatgc gcagcagacc 180
gaagcgcatc tggaaattcg tgaagatggc accgtgggcg gtgcggcgga tcagagcccg 240
gaaagcctgc tgcagctgaa agcgctgaaa ccgggcgtga ttcagattct gggcgtgaaa 300
accagccgtt ttctgtgcca gcgtccggat ggcgcgctgt atggcagcct gcattttgat 360
ccggaagcgt gcagctttcg tgaactgctg ctggaagatg gctataacgt gtatcagagc 420
gaagcgcatg gcctgccgct gcatctgccg ggcaacaaaa gcccgcattg cgatccggca 480
ccgcgtggtc cggcgcgttt tctgccgctg ccgggtctgc cgccggcact gccggaaccg 540
ccgggtattc tggccccgca gccgccggat gttggtagca gcgatccgct gtctatggtg 600
ggtccgagcc agggtcgtag cccgagctat gcgagctaa                        639

<210> 70
<211> 216
<212> PRT
<213> Homo sapiens

<400> 70
His Ser Glu Gly Thr Phe Thr Ser Asp Val Cys Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His
145                 150                 155                 160 
Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 71
<211> 651
<212> DNA
<213> Homo sapiens

<400> 71
cattctgaag gcacttttac tagcgatgtt tgtagctacc tggaaggcca ggctgcgaaa 60
gaattcatcg cgtggctggt taaaggcggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcagcaga ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
gatcagagcc cggaaagcct gctgcagctg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagcgtccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaacaa aagcccgcat 480
cgtgatccgg caccgcgtgg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctgtctatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 72
<211> 216
<212> PRT
<213> Homo sapiens

<400> 72
His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Cys Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His
145                 150                 155                 160 
Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 73
<211> 651
<212> DNA
<213> Homo sapiens

<400> 73
cattctgaag gcacttttac tagcgatgtt tctagctacc tggaaggctg tgctgcgaaa 60
gaattcatcg cgtggctggt taaaggcggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcagcaga ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
gatcagagcc cggaaagcct gctgcagctg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagcgtccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaacaa aagcccgcat 480
cgtgatccgg caccgcgtgg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctgtctatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 74
<211> 216
<212> PRT
<213> Homo sapiens

<400> 74
His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Cys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His
145                 150                 155                 160 
Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 75
<211> 651
<212> DNA
<213> Homo sapiens

<400> 75
cattctgaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgtgt 60
gaattcatcg cgtggctggt taaaggcggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcagcaga ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
gatcagagcc cggaaagcct gctgcagctg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagcgtccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaacaa aagcccgcat 480
cgtgatccgg caccgcgtgg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctgtctatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 76
<211> 216
<212> PRT
<213> Homo sapiens

<400> 76
His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Cys Phe Ile Ala Trp Leu Val Lys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His
145                 150                 155                 160 
Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 77
<211> 651
<212> DNA
<213> Homo sapiens

<400> 77
cattctgaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgaaa 60
tgtttcatcg cgtggctggt taaaggcggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcagcaga ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
gatcagagcc cggaaagcct gctgcagctg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagcgtccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaacaa aagcccgcat 480
cgtgatccgg caccgcgtgg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctgtctatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 78
<211> 216
<212> PRT
<213> Homo sapiens

<400> 78
His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Cys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His
145                 150                 155                 160 
Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 79
<211> 651
<212> DNA
<213> Homo sapiens

<400> 79
cattctgaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgaaa 60
gaattcatcg cgtggctggt ttgtggcggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcagcaga ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
gatcagagcc cggaaagcct gctgcagctg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagcgtccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaacaa aagcccgcat 480
cgtgatccgg caccgcgtgg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctgtctatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 80
<211> 216
<212> PRT
<213> Homo sapiens

<400> 80
His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Cys Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His
145                 150                 155                 160 
Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 81
<211> 651
<212> DNA
<213> Homo sapiens

<400> 81
cattctgaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgaaa 60
gaattcatcg cgtggctggt taaaggcggt tctggtggtg gtggttgtgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcagcaga ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
gatcagagcc cggaaagcct gctgcagctg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagcgtccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaacaa aagcccgcat 480
cgtgatccgg caccgcgtgg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctgtctatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 82
<211> 216
<212> PRT
<213> Homo sapiens

<400> 82
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Cys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His
145                 150                 155                 160 
Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 83
<211> 651
<212> DNA
<213> Homo sapiens

<400> 83
catgcggaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgtgt 60
gaattcatcg cgtggctggt taaaggcggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcagcaga ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
gatcagagcc cggaaagcct gctgcagctg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagcgtccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaacaa aagcccgcat 480
cgtgatccgg caccgcgtgg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctgtctatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 84
<211> 216
<212> PRT
<213> Homo sapiens

<400> 84
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Cys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His
145                 150                 155                 160 
Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 85
<211> 651
<212> DNA
<213> Homo sapiens

<400> 85
catgcggaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgaaa 60
gaattcatcg cgtggctggt ttgtggcggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcagcaga ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
gatcagagcc cggaaagcct gctgcagctg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagcgtccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaacaa aagcccgcat 480
cgtgatccgg caccgcgtgg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctgtctatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 86
<211> 216
<212> PRT
<213> Homo sapiens

<400> 86
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Cys Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His
145                 150                 155                 160 
Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 87
<211> 651
<212> DNA
<213> Homo sapiens

<400> 87
catgcggaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgaaa 60
gaattcatcg cgtggctggt taaaggcggt tctggtggtg gtggttgtgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcagcaga ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
gatcagagcc cggaaagcct gctgcagctg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagcgtccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaacaa aagcccgcat 480
cgtgatccgg caccgcgtgg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctgtctatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 88
<211> 216
<212> PRT
<213> Homo sapiens

<400> 88
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His
145                 150                 155                 160 
Cys Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 89
<211> 651
<212> DNA
<213> Homo sapiens

<400> 89
catggtgagg gtacgtttac ttctgatctg tctaaacaga tggaagaaga agctgttcgc 60
ctgttcattg aatggctgaa aaatggtggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcagcaga ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
gatcagagcc cggaaagcct gctgcagctg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagcgtccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaacaa aagcccgcat 480
tgcgatccgg caccgcgtgg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctgtctatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 90
<211> 216
<212> PRT
<213> Homo sapiens

<400> 90
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Gly
 1               5                  10                  15      
Gln Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His
145                 150                 155                 160 
Cys Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 91
<211> 651
<212> DNA
<213> Homo sapiens

<400> 91
catggtgagg gtacgtttac ttctgatctg tctaaacaga tggaagggca agctgttcgc 60
ctgttcattg aatggctgaa aaatggtggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcagcaga ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
gatcagagcc cggaaagcct gctgcagctg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagcgtccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaacaa aagcccgcat 480
tgcgatccgg caccgcgtgg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctgtctatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 92
<211> 216
<212> PRT
<213> Homo sapiens

<220> 
<223> Non-natural amino acid

<400> 92
His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Cys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His
145                 150                 155                 160 
Xaa Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 93
<211> 651
<212> DNA
<213> Homo sapiens

<400> 93
cattctgaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgaaa 60
gaattcatcg cgtggctggt ttgtggcggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcagcaga ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
gatcagagcc cggaaagcct gctgcagctg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagcgtccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaacaa aagcccgcat 480
taggatccgg caccgcgtgg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctgtctatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 94
<211> 216
<212> PRT
<213> Homo sapiens

<220> 
<223> Non-natural amino acid

<400> 94
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Cys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His
145                 150                 155                 160 
Xaa Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 95
<211> 651
<212> DNA
<213> Homo sapiens

<400> 95
catgcggaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgaaa 60
gaattcatcg cgtggctggt ttgtggcggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcagcaga ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
gatcagagcc cggaaagcct gctgcagctg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagcgtccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaacaa aagcccgcat 480
taggatccgg caccgcgtgg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctgtctatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 96
<211> 216
<212> PRT
<213> Homo sapiens

<220> 
<223> Non-natural amino acid

<400> 96
His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Xaa Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His
145                 150                 155                 160 
Cys Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 97
<211> 651
<212> DNA
<213> Homo sapiens

<400> 97
cattctgaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgaaa 60
gaattcatcg cgtggctggt ttagggcggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcagcaga ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
gatcagagcc cggaaagcct gctgcagctg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagcgtccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaacaa aagcccgcat 480
tgcgatccgg caccgcgtgg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctgtctatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 98
<211> 216
<212> PRT
<213> Homo sapiens

<400> 98
His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Glu Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
His Gln Ser Pro Glu Ser Leu Leu Glu Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Lys
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Arg Ser Pro His
145                 150                 155                 160 
Arg Asp Pro Ala Pro Gln Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ala Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 99
<211> 651
<212> DNA
<213> Homo sapiens

<400> 99
cattctgaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgaaa 60
gaattcatcg cgtggctggt taaaggcggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcaggaaa ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
catcagagcc cggaaagcct gctggaactg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagaaaccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaaccg tagcccgcat 480
cgtgatccgg caccgcaggg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctggcgatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 100
<211> 216
<212> PRT
<213> Homo sapiens

<400> 100
His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Glu Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
His Gln Ser Pro Glu Ser Leu Leu Glu Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Lys
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Glu Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Arg Ser Pro His
145                 150                 155                 160 
Arg Asp Pro Ala Pro Gln Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ala Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 101
<211> 651
<212> DNA
<213> Homo sapiens

<400> 101
cattctgaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgaaa 60
gaattcatcg cgtggctggt taaaggcggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcaggaaa ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
catcagagcc cggaaagcct gctggaactg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagaaaccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga aggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaaccg tagcccgcat 480
cgtgatccgg caccgcaggg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctggcgatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 102
<211> 216
<212> PRT
<213> Homo sapiens

<400> 102
His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Cys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Glu Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
His Gln Ser Pro Glu Ser Leu Leu Glu Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Lys
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Glu Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Arg Ser Pro His
145                 150                 155                 160 
Arg Asp Pro Ala Pro Gln Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ala Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 103
<211> 651
<212> DNA
<213> Homo sapiens

<400> 103
cattctgaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgaaa 60
gaattcatcg cgtggctggt ttgtggcggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcaggaaa ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
catcagagcc cggaaagcct gctggaactg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagaaaccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga aggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaaccg tagcccgcat 480
cgtgatccgg caccgcaggg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctggcgatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 104
<211> 216
<212> PRT
<213> Homo sapiens

<400> 104
His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Cys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Glu Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
His Gln Ser Pro Glu Ser Leu Leu Glu Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Lys
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Arg Ser Pro His
145                 150                 155                 160 
Arg Asp Pro Ala Pro Gln Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ala Met Val Gly Pro Ser Gln
        195                 200                 205             
Ala Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 105
<211> 651
<212> DNA
<213> Homo sapiens

<400> 105
cattctgaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgaaa 60
gaattcatcg cgtggctggt ttgtggcggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcaggaaa ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
catcagagcc cggaaagcct gctggaactg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagaaaccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaaccg tagcccgcat 480
cgtgatccgg caccgcaggg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctggcgatgg tgggtccgag ccaggcgcgt agcccgagct atgcgagcta a          651

<210> 106
<211> 216
<212> PRT
<213> Homo sapiens

<400> 106
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Glu Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
His Gln Ser Pro Glu Ser Leu Leu Glu Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Lys
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Arg Ser Pro His
145                 150                 155                 160 
Arg Asp Pro Ala Pro Gln Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ala Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 107
<211> 651
<212> DNA
<213> Homo sapiens

<400> 107
catggtgagg gtacgtttac ttctgatctg tctaaacaga tggaagaaga agctgttcgc 60
ctgttcattg aatggctgaa aaatggtggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcaggaaa ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
catcagagcc cggaaagcct gctggaactg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagaaaccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaaccg tagcccgcat 480
cgtgatccgg caccgcaggg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctggcgatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 108
<211> 216
<212> PRT
<213> Homo sapiens

<400> 108
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Glu Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
His Gln Ser Pro Glu Ser Leu Leu Glu Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Lys
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Glu Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Arg Ser Pro His
145                 150                 155                 160 
Arg Asp Pro Ala Pro Gln Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ala Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 109
<211> 651
<212> DNA
<213> Homo sapiens

<400> 109
catggtgagg gtacgtttac ttctgatctg tctaaacaga tggaagaaga agctgttcgc 60
ctgttcattg aatggctgaa aaatggtggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcaggaaa ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
catcagagcc cggaaagcct gctggaactg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagaaaccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga aggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaaccg tagcccgcat 480
cgtgatccgg caccgcaggg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctggcgatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 110
<211> 216
<212> PRT
<213> Homo sapiens

<400> 110
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Cys Asn Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Glu Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
His Gln Ser Pro Glu Ser Leu Leu Glu Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Lys
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Glu Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Arg Ser Pro His
145                 150                 155                 160 
Arg Asp Pro Ala Pro Gln Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ala Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 111
<211> 651
<212> DNA
<213> Homo sapiens

<400> 111
catggtgagg gtacgtttac ttctgatctg tctaaacaga tggaagaaga agctgttcgc 60
ctgttcattg aatggctgtg taatggtggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcaggaaa ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
catcagagcc cggaaagcct gctggaactg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagaaaccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga aggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaaccg tagcccgcat 480
cgtgatccgg caccgcaggg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctggcgatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 112
<211> 216
<212> PRT
<213> Homo sapiens

<400> 112
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Cys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Glu Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
His Gln Ser Pro Glu Ser Leu Leu Glu Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Lys
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Glu Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Arg Ser Pro His
145                 150                 155                 160 
Arg Asp Pro Ala Pro Gln Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ala Met Val Gly Pro Ser Gln
        195                 200                 205             
Gly Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 113
<211> 651
<212> DNA
<213> Homo sapiens

<400> 113
catggtgagg gtacgtttac ttctgatctg tctaaacaga tggaagaaga agctgttcgc 60
ctgttcattg aatggctgaa atgtggtggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcaggaaa ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
catcagagcc cggaaagcct gctggaactg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagaaaccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga aggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaaccg tagcccgcat 480
cgtgatccgg caccgcaggg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctggcgatgg tgggtccgag ccagggtcgt agcccgagct atgcgagcta a          651

<210> 114
<211> 216
<212> PRT
<213> Homo sapiens

<400> 114
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Cys Asn Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Glu Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
His Gln Ser Pro Glu Ser Leu Leu Glu Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Lys
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Arg Ser Pro His
145                 150                 155                 160 
Arg Asp Pro Ala Pro Gln Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ala Met Val Gly Pro Ser Gln
        195                 200                 205             
Ala Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 115
<211> 651
<212> DNA
<213> Homo sapiens

<400> 115
catggtgagg gtacgtttac ttctgatctg tctaaacaga tggaagaaga agctgttcgc 60
ctgttcattg aatggctgtg taatggtggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcaggaaa ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
catcagagcc cggaaagcct gctggaactg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagaaaccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaaccg tagcccgcat 480
cgtgatccgg caccgcaggg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctggcgatgg tgggtccgag ccaggcgcgt agcccgagct atgcgagcta a          651

<210> 116
<211> 216
<212> PRT
<213> Homo sapiens

<400> 116
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Cys Gly Gly Ser Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly
        35                  40                  45              
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Glu Thr
    50                  55                  60                  
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
65                  70                  75                  80  
His Gln Ser Pro Glu Ser Leu Leu Glu Leu Lys Ala Leu Lys Pro Gly
                85                  90                  95      
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Lys
            100                 105                 110         
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys
        115                 120                 125             
Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser
    130                 135                 140                 
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Arg Ser Pro His
145                 150                 155                 160 
Arg Asp Pro Ala Pro Gln Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly
                165                 170                 175     
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro
            180                 185                 190         
Pro Asp Val Gly Ser Ser Asp Pro Leu Ala Met Val Gly Pro Ser Gln
        195                 200                 205             
Ala Arg Ser Pro Ser Tyr Ala Ser
    210                 215     


<210> 117
<211> 651
<212> DNA
<213> Homo sapiens

<400> 117
catggtgagg gtacgtttac ttctgatctg tctaaacaga tggaagaaga agctgttcgc 60
ctgttcattg aatggctgaa atgtggtggt tctggtggtg gtggttctgg cggtggcgac 120
tcgagcccgc tgctgcagtt tggcggccag gtgcgtcagc gttatctgta taccgatgat 180
gcgcaggaaa ccgaagcgca tctggaaatt cgtgaagatg gcaccgtggg cggtgcggcg 240
catcagagcc cggaaagcct gctggaactg aaagcgctga aaccgggcgt gattcagatt 300
ctgggcgtga aaaccagccg ttttctgtgc cagaaaccgg atggcgcgct gtatggcagc 360
ctgcattttg atccggaagc gtgcagcttt cgtgaactgc tgctggaaga tggctataac 420
gtgtatcaga gcgaagcgca tggcctgccg ctgcatctgc cgggcaaccg tagcccgcat 480
cgtgatccgg caccgcaggg tccggcgcgt tttctgccgc tgccgggtct gccgccggca 540
ctgccggaac cgccgggtat tctggccccg cagccgccgg atgttggtag cagcgatccg 600
ctggcgatgg tgggtccgag ccaggcgcgt agcccgagct atgcgagcta a          651

<210> 118
<211> 227
<212> PRT
<213> Homo sapiens

<400> 118
His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
 1               5                  10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Ser
            20                  25                  30          
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
        35                  40                  45              
Gly Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln
    50                  55                  60                  
Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Glu Thr Glu Ala His Leu Glu
65                  70                  75                  80  
Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala His Gln Ser Pro Glu
                85                  90                  95      
Ser Leu Leu Glu Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu
            100                 105                 110         
Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Lys Pro Asp Gly Ala Leu
        115                 120                 125             
Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu
    130                 135                 140                 
Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu
145                 150                 155                 160 
Pro Leu His Leu Pro Gly Asn Arg Ser Pro His Cys Asp Pro Ala Pro
                165                 170                 175     
Gln Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu
            180                 185                 190         
Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser
        195                 200                 205             
Ser Asp Pro Leu Ala Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser
    210                 215                 220                 
Tyr Ala Ser
225         


<210> 119
<211> 684
<212> DNA
<213> Homo sapiens

<400> 119
cattctgaag gcacttttac tagcgatgtt tctagctacc tggaaggcca ggctgcgaaa 60
gaattcatcg cgtggctggt taaaggcggt ggtagcggtg gcggcggttc tggtggtggt 120
ggttctggcg gtggcggtag cggtggcggc gatagcagcc cgctgctgca gtttggcggc 180
caggtgcgtc agcgttatct gtataccgat gatgcgcagg aaaccgaagc gcatctggaa 240
attcgtgaag atggcaccgt gggcggtgcg gcgcatcaga gcccggaaag cctgctggaa 300
ctgaaagcgc tgaaaccggg cgtgattcag attctgggcg tgaaaaccag ccgttttctg 360
tgccagaaac cggatggcgc gctgtatggc agcctgcatt ttgatccgga agcgtgcagc 420
tttcgtgaac tgctgctgga agatggctat aacgtgtatc agagcgaagc gcatggcctg 480
ccgctgcatc tgccgggcaa ccgtagcccg cattgcgatc cggcaccgca gggtccggcg 540
cgttttctgc cgctgccggg tctgccgccg gcactgccgg aaccgccggg tattctggcc 600
ccgcagccgc cggatgttgg tagcagcgat ccgctggcga tggtgggtcc gagccagggt 660
cgtagcccga gctatgcgag ctaa                                        684

<210> 120
<211> 474
<212> PRT
<213> Homo sapiens

<400> 120
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys
            20                  25                  30          
Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn
        35                  40                  45              
Gly Gly Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys
    50                  55                  60                  
Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
65                  70                  75                  80  
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
                85                  90                  95      
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
            100                 105                 110         
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
        115                 120                 125             
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
    130                 135                 140                 
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
145                 150                 155                 160 
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
                165                 170                 175     
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
            180                 185                 190         
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
        195                 200                 205             
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
    210                 215                 220                 
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
225                 230                 235                 240 
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
                245                 250                 255     
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
            260                 265                 270         
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly
        275                 280                 285             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ser Ser Pro Leu Leu Gln
    290                 295                 300                 
Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys
305                 310                 315                 320 
Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly
                325                 330                 335     
Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys
            340                 345                 350         
Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys
        355                 360                 365             
Gln Lys Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu
    370                 375                 380                 
Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr
385                 390                 395                 400 
Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Cys Asn Arg Ser
                405                 410                 415     
Pro His Arg Asp Pro Ala Ser Arg Gly Pro Ala Arg Phe Leu Pro Leu
            420                 425                 430         
Pro Gly Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro
        435                 440                 445             
Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ala Met Val Gly Gly
    450                 455                 460                 
Ser Gln Ala Arg Ser Pro Ser Tyr Ala Ser
465                 470                 


<210> 121
<211> 484
<212> PRT
<213> Homo sapiens

<400> 121
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys
            20                  25                  30          
Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn
        35                  40                  45              
Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
    50                  55                  60                  
Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala
65                  70                  75                  80  
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
                85                  90                  95      
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
            100                 105                 110         
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
        115                 120                 125             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
    130                 135                 140                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
145                 150                 155                 160 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
                165                 170                 175     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
            180                 185                 190         
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val
        195                 200                 205             
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
    210                 215                 220                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
225                 230                 235                 240 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
                245                 250                 255     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
            260                 265                 270         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
        275                 280                 285             
Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
    290                 295                 300                 
Gly Gly Ser Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg
305                 310                 315                 320 
Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr Glu Ala His Leu
                325                 330                 335     
Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro
            340                 345                 350         
Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile
        355                 360                 365             
Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Lys Pro Asp Gly Ala
    370                 375                 380                 
Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu
385                 390                 395                 400 
Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly
                405                 410                 415     
Leu Pro Leu His Leu Pro Cys Asn Arg Ser Pro His Arg Asp Pro Ala
            420                 425                 430         
Ser Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala
        435                 440                 445             
Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly
    450                 455                 460                 
Ser Ser Asp Pro Leu Ala Met Val Gly Gly Ser Gln Ala Arg Ser Pro
465                 470                 475                 480 
Ser Tyr Ala Ser
                


<210> 122
<211> 483
<212> PRT
<213> Homo sapiens

<400> 122
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys
            20                  25                  30          
Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn
        35                  40                  45              
Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser
    50                  55                  60                  
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly
65                  70                  75                  80  
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                85                  90                  95      
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
            100                 105                 110         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
        115                 120                 125             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
    130                 135                 140                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
145                 150                 155                 160 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
                165                 170                 175     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
            180                 185                 190         
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
        195                 200                 205             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    210                 215                 220                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
225                 230                 235                 240 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                245                 250                 255     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            260                 265                 270         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        275                 280                 285             
Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
    290                 295                 300                 
Gly Ser Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln
305                 310                 315                 320 
Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr Glu Ala His Leu Glu
                325                 330                 335     
Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu
            340                 345                 350         
Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu
        355                 360                 365             
Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Lys Pro Asp Gly Ala Leu
    370                 375                 380                 
Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu
385                 390                 395                 400 
Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu
                405                 410                 415     
Pro Leu His Leu Pro Cys Asn Arg Ser Pro His Arg Asp Pro Ala Ser
            420                 425                 430         
Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu
        435                 440                 445             
Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser
    450                 455                 460                 
Ser Asp Pro Leu Ala Met Val Gly Gly Ser Gln Ala Arg Ser Pro Ser
465                 470                 475                 480 
Tyr Ala Ser
            


<210> 123
<211> 493
<212> PRT
<213> Homo sapiens

<400> 123
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys
            20                  25                  30          
Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn
        35                  40                  45              
Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser
    50                  55                  60                  
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys
65                  70                  75                  80  
Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu
                85                  90                  95      
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
            100                 105                 110         
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
        115                 120                 125             
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
    130                 135                 140                 
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
145                 150                 155                 160 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
                165                 170                 175     
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
            180                 185                 190         
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
        195                 200                 205             
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
    210                 215                 220                 
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
225                 230                 235                 240 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
                245                 250                 255     
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
            260                 265                 270         
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
        275                 280                 285             
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly
    290                 295                 300                 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ser Ser Pro
305                 310                 315                 320 
Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp
                325                 330                 335     
Asp Ala Cys Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr
            340                 345                 350         
Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys
        355                 360                 365             
Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg
    370                 375                 380                 
Phe Leu Cys Gln Lys Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe
385                 390                 395                 400 
Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr
                405                 410                 415     
Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Cys
            420                 425                 430         
Asn Arg Ser Pro His Arg Asp Pro Ala Ser Arg Gly Pro Ala Arg Phe
        435                 440                 445             
Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile
    450                 455                 460                 
Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ala Met
465                 470                 475                 480 
Val Gly Gly Ser Gln Ala Arg Ser Pro Ser Tyr Ala Ser
                485                 490             


<210> 124
<211> 473
<212> PRT
<213> Homo sapiens

<400> 124
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser
            20                  25                  30          
Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys
        35                  40                  45              
Gly Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro
    50                  55                  60                  
Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
65                  70                  75                  80  
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
                85                  90                  95      
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
            100                 105                 110         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
        115                 120                 125             
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
    130                 135                 140                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
145                 150                 155                 160 
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
                165                 170                 175     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met
            180                 185                 190         
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
        195                 200                 205             
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
    210                 215                 220                 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
225                 230                 235                 240 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
                245                 250                 255     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
            260                 265                 270         
Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly
        275                 280                 285             
Gly Gly Ser Gly Gly Gly Gly Ser Asp Ser Ser Pro Leu Leu Gln Phe
    290                 295                 300                 
Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln
305                 310                 315                 320 
Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala
                325                 330                 335     
Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro
            340                 345                 350         
Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln
        355                 360                 365             
Lys Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala
    370                 375                 380                 
Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln
385                 390                 395                 400 
Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Cys Asn Arg Ser Pro
                405                 410                 415     
His Arg Asp Pro Ala Ser Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro
            420                 425                 430         
Gly Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln
        435                 440                 445             
Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ala Met Val Gly Gly Ser
    450                 455                 460                 
Gln Ala Arg Ser Pro Ser Tyr Ala Ser
465                 470             


<210> 125
<211> 483
<212> PRT
<213> Homo sapiens

<400> 125
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser
            20                  25                  30          
Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys
        35                  40                  45              
Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
    50                  55                  60                  
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly
65                  70                  75                  80  
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                85                  90                  95      
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
            100                 105                 110         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
        115                 120                 125             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
    130                 135                 140                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
145                 150                 155                 160 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
                165                 170                 175     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
            180                 185                 190         
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
        195                 200                 205             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    210                 215                 220                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
225                 230                 235                 240 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                245                 250                 255     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            260                 265                 270         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        275                 280                 285             
Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
    290                 295                 300                 
Gly Ser Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln
305                 310                 315                 320 
Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr Glu Ala His Leu Glu
                325                 330                 335     
Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu
            340                 345                 350         
Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu
        355                 360                 365             
Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Lys Pro Asp Gly Ala Leu
    370                 375                 380                 
Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu
385                 390                 395                 400 
Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu
                405                 410                 415     
Pro Leu His Leu Pro Cys Asn Arg Ser Pro His Arg Asp Pro Ala Ser
            420                 425                 430         
Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu
        435                 440                 445             
Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser
    450                 455                 460                 
Ser Asp Pro Leu Ala Met Val Gly Gly Ser Gln Ala Arg Ser Pro Ser
465                 470                 475                 480 
Tyr Ala Ser
            


<210> 126
<211> 235
<212> PRT
<213> Homo sapiens

<400> 126
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
 1               5                  10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser
            20                  25                  30          
Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
        35                  40                  45              
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Asp Ser Ser Pro Leu Leu
    50                  55                  60                  
Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala
65                  70                  75                  80  
Gln Glu Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly
                85                  90                  95      
Gly Ala Ala His Gln Ser Pro Glu Ser Leu Leu Glu Leu Lys Ala Leu
            100                 105                 110         
Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu
        115                 120                 125             
Cys Gln Lys Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro
    130                 135                 140                 
Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val
145                 150                 155                 160 
Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Arg
                165                 170                 175     
Ser Pro His Cys Asp Pro Ala Pro Gln Gly Pro Ala Arg Phe Leu Pro
            180                 185                 190         
Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala
        195                 200                 205             
Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ala Met Val Gly
    210                 215                 220                 
Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser
225                 230                 235 


<210> 127
<211> 708
<212> DNA
<213> Homo sapiens

<400> 127
catggtgagg gtacgtttac ttctgatctg tctaaacaga tggaagaaga agctgttcgc 60
ctgttcattg aatggctgaa aaatggtggt ccgtcctccg gcgctcctcc gccttctggt 120
ggtggtggtt ctggcggtgg cggttctggc ggcggtggta gcggtggcgg cggtgatagc 180
agcccgctgc tgcagtttgg cggccaggtg cgtcagcgtt atctgtatac cgatgatgcg 240
caggaaaccg aagcgcatct ggaaattcgt gaagatggca ccgtgggcgg tgcggcgcat 300
cagagcccgg aaagcctgct ggaactgaaa gcgctgaaac cgggcgtgat tcagattctg 360
ggcgtgaaaa ccagccgttt tctgtgccag aaaccggatg gcgcgctgta tggcagcctg 420
cattttgatc cggaagcgtg cagctttcgt gaactgctgc tggaagatgg ctataacgtg 480
tatcagagcg aagcgcatgg cctgccgctg catctgccgg gcaaccgtag cccgcattgc 540
gatccggcac cgcagggtcc ggcgcgtttt ctgccgctgc cgggtctgcc gccggcactg 600
ccggaaccgc cgggtattct ggccccgcag ccgccggatg ttggtagcag cgatccgctg 660
gcgatggtgg gtccgagcca gggtcgtagc ccgagctatg cgagctaa              708

<210> 128
<211> 9
<212> DNA
<213> Homo sapiens

<400> 128
sggggsggg                                                         9

<210> 129
<211> 37
<212> PRT
<213> Homo sapiens

<400> 129
His Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val
 1               5                  10                  15      
Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu
            20                  25                  30          
Val Lys Gly Arg Gly
        35          


<210> 130
<211> 177
<212> PRT
<213> Homo sapiens

<400> 130
Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr
 1               5                  10                  15      
Leu Tyr Thr Asp Asp Ala Gln Glu Thr Glu Ala His Leu Glu Ile Arg
            20                  25                  30          
Glu Asp Gly Thr Val Gly Gly Ala Ala His Gln Ser Pro Glu Ser Leu
        35                  40                  45              
Leu Glu Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val
    50                  55                  60                  
Lys Thr Ser Arg Phe Leu Cys Gln Lys Pro Asp Gly Ala Leu Tyr Gly
65                  70                  75                  80  
Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu
                85                  90                  95      
Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu
            100                 105                 110         
His Leu Pro Gly Asn Arg Ser Pro His Cys Asp Pro Ala Pro Gln Gly
        115                 120                 125             
Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu
    130                 135                 140                 
Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp
145                 150                 155                 160 
Pro Leu Ala Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala
                165                 170                 175     
Ser
    


<210> 131
<211> 177
<212> PRT
<213> Homo sapiens

<400> 131
Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr
 1               5                  10                  15      
Leu Tyr Thr Asp Asp Ala Gln Glu Thr Glu Ala His Leu Glu Ile Arg
            20                  25                  30          
Glu Asp Gly Thr Val Gly Gly Ala Ala His Gln Ser Pro Glu Ser Leu
        35                  40                  45              
Leu Glu Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val
    50                  55                  60                  
Lys Thr Ser Arg Phe Leu Cys Gln Lys Pro Asp Gly Ala Leu Tyr Gly
65                  70                  75                  80  
Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu
                85                  90                  95      
Glu Glu Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu
            100                 105                 110         
His Leu Pro Gly Asn Arg Ser Pro His Arg Asp Pro Ala Pro Gln Gly
        115                 120                 125             
Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu
    130                 135                 140                 
Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp
145                 150                 155                 160 
Pro Leu Ala Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala
                165                 170                 175     
Ser
    


<210> 132
<211> 28
<212> PRT
<213> Homo sapiens

<400> 132
Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser
 1               5                  10                  15      
Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala
            20                  25              

