                         SEQUENCE LISTING

<110>  Novozymes, Inc.
       Novozymes A/S
       Tassone, Monica
       De Maria, Leonardo
 
<120>  Dehydrogenase variants and polynucleotides encoding same

<130>  12306-WO-PCT

<150>  US 61/541,363
<151>  2011-09-30

<160>  82    

<170>  PatentIn version 3.5

<210>  1
<211>  747
<212>  DNA
<213>  Escherichia coli

<400>  1
atgatcgttt tggtcaccgg tgcaaccgca ggtttcggcg aatgtatcac cagaagattc       60

atccagcagg gtcacaaggt tatcgctacc ggtagaagac aagagagatt gcaagaattg      120

aaggacgagt tgggtgacaa cttgtacatc gctcaattgg acgttagaaa cagagcagct      180

atcgaagaaa tgttggcatc cttgccagct gaatggtgca acatcgacat cttggtcaac      240

aacgctggtt tggcattggg tatggaacca gctcacaagg ctagtgttga ggactgggag      300

accatgatcg acaccaacaa caagggtttg gtctacatga ccagagcagt tttgcctggt      360

atggttgaaa gaaaccacgg tcacatcatc aacatcggtt ccaccgctgg ttcctggcca      420

tacgctggcg gtaacgtcta cggtgctacc aaggctttcg ttagacagtt ctccttgaac      480

ttgagaaccg acttgcacgg caccgctgtt agagttaccg acatcgaacc aggtttggtt      540

ggtggcaccg aattctccaa cgtcagattc aagggcgacg acggtaaggc tgaaaagacc      600

taccaaaaca ccgtcgcttt gaccccagaa gacgtttcag aggctgtttg gtgggtcagt      660

accttgccag cacacgtcaa catcaacacc ttggaaatga tgccagtcac ccaatcctac      720

gcaggtttga acgttcacag acaataa                                          747


<210>  2
<211>  248
<212>  PRT
<213>  Escherichia coli

<400>  2

Met Ile Val Leu Val Thr Gly Ala Thr Ala Gly Phe Gly Glu Cys Ile 
1               5                   10                  15      


Thr Arg Arg Phe Ile Gln Gln Gly His Lys Val Ile Ala Thr Gly Arg 
            20                  25                  30          


Arg Gln Glu Arg Leu Gln Glu Leu Lys Asp Glu Leu Gly Asp Asn Leu 
        35                  40                  45              


Tyr Ile Ala Gln Leu Asp Val Arg Asn Arg Ala Ala Ile Glu Glu Met 
    50                  55                  60                  


Leu Ala Ser Leu Pro Ala Glu Trp Cys Asn Ile Asp Ile Leu Val Asn 
65                  70                  75                  80  


Asn Ala Gly Leu Ala Leu Gly Met Glu Pro Ala His Lys Ala Ser Val 
                85                  90                  95      


Glu Asp Trp Glu Thr Met Ile Asp Thr Asn Asn Lys Gly Leu Val Tyr 
            100                 105                 110         


Met Thr Arg Ala Val Leu Pro Gly Met Val Glu Arg Asn His Gly His 
        115                 120                 125             


Ile Ile Asn Ile Gly Ser Thr Ala Gly Ser Trp Pro Tyr Ala Gly Gly 
    130                 135                 140                 


Asn Val Tyr Gly Ala Thr Lys Ala Phe Val Arg Gln Phe Ser Leu Asn 
145                 150                 155                 160 


Leu Arg Thr Asp Leu His Gly Thr Ala Val Arg Val Thr Asp Ile Glu 
                165                 170                 175     


Pro Gly Leu Val Gly Gly Thr Glu Phe Ser Asn Val Arg Phe Lys Gly 
            180                 185                 190         


Asp Asp Gly Lys Ala Glu Lys Thr Tyr Gln Asn Thr Val Ala Leu Thr 
        195                 200                 205             


Pro Glu Asp Val Ser Glu Ala Val Trp Trp Val Ser Thr Leu Pro Ala 
    210                 215                 220                 


His Val Asn Ile Asn Thr Leu Glu Met Met Pro Val Thr Gln Ser Tyr 
225                 230                 235                 240 


Ala Gly Leu Asn Val His Arg Gln 
                245             


<210>  3
<211>  813
<212>  DNA
<213>  Issatchenkia orientalis

<400>  3
atgtttggta atatttccca aagacttgca ggcaagaaca tcctaattac aggtgcgtcc       60

actggtatcg gataccatac agcaaagtat tttgcagaag ctgcaaatgg agacttgaag      120

ttggttttgg ctgcaagaag aaaggagaag ctggaggcac taaaggcaga cttgcttgcc      180

aagtatccat ccatcaaagt ccatattgag agtttggatg tctccaaaac ggaaaccatt      240

gcacctttct taaaaggttt acctgaggaa ttttcaattg tcgacgtgtt ggtcaacaat      300

gcaggtaagg cgcttggttt ggatccaatt ggctctgtcg atccaaagga cgtggatgaa      360

atgttccaga ccaatgtttt gggtatgatt caattgaccc agttggttgt acagcaaatg      420

aaggagagaa actccgggga cattgtccaa ctaggttcag tggctggtag aaacccatac      480

ccaggtggtg gtatctactg tgcctccaag gccgcattga gatcttttac acatgtattg      540

agagaggaat tgattaatac caagattaga gtgattgaaa tcgagcctgg aaatgttgca      600

actgaggaat tttctttgac cagattcaaa ggtgataagt ccaaggccga aaaggtctat      660

gagggaaccg agccattgta tggtaccgat attgcagaat tgattctatt tgcagtttct      720

agacctcaaa acactgttat tgcagaaaca cttgtttttg ctagtaacca agcttctgct      780

taccatattt tcagaggatc attagataaa tag                                   813


<210>  4
<211>  270
<212>  PRT
<213>  Issatchenkia orientalis

<400>  4

Met Phe Gly Asn Ile Ser Gln Arg Leu Ala Gly Lys Asn Ile Leu Ile 
1               5                   10                  15      


Thr Gly Ala Ser Thr Gly Ile Gly Tyr His Thr Ala Lys Tyr Phe Ala 
            20                  25                  30          


Glu Ala Ala Asn Gly Asp Leu Lys Leu Val Leu Ala Ala Arg Arg Lys 
        35                  40                  45              


Glu Lys Leu Glu Ala Leu Lys Ala Asp Leu Leu Ala Lys Tyr Pro Ser 
    50                  55                  60                  


Ile Lys Val His Ile Glu Ser Leu Asp Val Ser Lys Thr Glu Thr Ile 
65                  70                  75                  80  


Ala Pro Phe Leu Lys Gly Leu Pro Glu Glu Phe Ser Ile Val Asp Val 
                85                  90                  95      


Leu Val Asn Asn Ala Gly Lys Ala Leu Gly Leu Asp Pro Ile Gly Ser 
            100                 105                 110         


Val Asp Pro Lys Asp Val Asp Glu Met Phe Gln Thr Asn Val Leu Gly 
        115                 120                 125             


Met Ile Gln Leu Thr Gln Leu Val Val Gln Gln Met Lys Glu Arg Asn 
    130                 135                 140                 


Ser Gly Asp Ile Val Gln Leu Gly Ser Val Ala Gly Arg Asn Pro Tyr 
145                 150                 155                 160 


Pro Gly Gly Gly Ile Tyr Cys Ala Ser Lys Ala Ala Leu Arg Ser Phe 
                165                 170                 175     


Thr His Val Leu Arg Glu Glu Leu Ile Asn Thr Lys Ile Arg Val Ile 
            180                 185                 190         


Glu Ile Glu Pro Gly Asn Val Ala Thr Glu Glu Phe Ser Leu Thr Arg 
        195                 200                 205             


Phe Lys Gly Asp Lys Ser Lys Ala Glu Lys Val Tyr Glu Gly Thr Glu 
    210                 215                 220                 


Pro Leu Tyr Gly Thr Asp Ile Ala Glu Leu Ile Leu Phe Ala Val Ser 
225                 230                 235                 240 


Arg Pro Gln Asn Thr Val Ile Ala Glu Thr Leu Val Phe Ala Ser Asn 
                245                 250                 255     


Gln Ala Ser Ala Tyr His Ile Phe Arg Gly Ser Leu Asp Lys 
            260                 265                 270 


<210>  5
<211>  804
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  5
atgtcccaag gtagaaaggc agcagaaaga ttggcaaaga agaccgtctt gatcaccggt       60

gcgtccgctg gtatcggtaa ggctaccgcg ttggagtact tggaagcatc caacggtgac      120

atgaagttga tcttggcagc aagaagattg gagaagttgg aagaattgaa gaagaccatc      180

gaccaagaat tcccaaacgc taaggtccac gttgcacaat tggacatcac ccaagcagag      240

aagatcaagc cattcatcga aaacttgcca caagaattca aggacatcga catcttggtc      300

aacaacgctg gtaaggcgtt gggttccgac agagttggtc aaatcgcaac cgaagacatc      360

caagacgtct tcgacaccaa cgtcaccgct ttgatcaaca tcacccaagc tgttttgcca      420

atcttccaag cgaagaactc cggtgacatc gtcaacttgg gttccatcgc tggtagagac      480

gcatacccaa ccggctccat ctactgcgcc tccaagttcg ctgtcggtgc tttcaccgac      540

tccttgagaa aggaattgat caacaccaag atcagagtca tcttgattgc ccctggtttg      600

gtcgaaaccg aattctcctt ggttagatac agaggtaacg aagaacaagc aaagaacgtt      660

tacaaggaca ctaccccatt gatggccgac gacgttgcag acttgatcgt ttacgctacc      720

tccagaaagc aaaacaccgt tatcgcagac accttgatct tcccaaccaa ccaagcatcc      780

ccacaccaca tcttcagagg ttaa                                             804


<210>  6
<211>  267
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  6

Met Ser Gln Gly Arg Lys Ala Ala Glu Arg Leu Ala Lys Lys Thr Val 
1               5                   10                  15      


Leu Ile Thr Gly Ala Ser Ala Gly Ile Gly Lys Ala Thr Ala Leu Glu 
            20                  25                  30          


Tyr Leu Glu Ala Ser Asn Gly Asp Met Lys Leu Ile Leu Ala Ala Arg 
        35                  40                  45              


Arg Leu Glu Lys Leu Glu Glu Leu Lys Lys Thr Ile Asp Gln Glu Phe 
    50                  55                  60                  


Pro Asn Ala Lys Val His Val Ala Gln Leu Asp Ile Thr Gln Ala Glu 
65                  70                  75                  80  


Lys Ile Lys Pro Phe Ile Glu Asn Leu Pro Gln Glu Phe Lys Asp Ile 
                85                  90                  95      


Asp Ile Leu Val Asn Asn Ala Gly Lys Ala Leu Gly Ser Asp Arg Val 
            100                 105                 110         


Gly Gln Ile Ala Thr Glu Asp Ile Gln Asp Val Phe Asp Thr Asn Val 
        115                 120                 125             


Thr Ala Leu Ile Asn Ile Thr Gln Ala Val Leu Pro Ile Phe Gln Ala 
    130                 135                 140                 


Lys Asn Ser Gly Asp Ile Val Asn Leu Gly Ser Ile Ala Gly Arg Asp 
145                 150                 155                 160 


Ala Tyr Pro Thr Gly Ser Ile Tyr Cys Ala Ser Lys Phe Ala Val Gly 
                165                 170                 175     


Ala Phe Thr Asp Ser Leu Arg Lys Glu Leu Ile Asn Thr Lys Ile Arg 
            180                 185                 190         


Val Ile Leu Ile Ala Pro Gly Leu Val Glu Thr Glu Phe Ser Leu Val 
        195                 200                 205             


Arg Tyr Arg Gly Asn Glu Glu Gln Ala Lys Asn Val Tyr Lys Asp Thr 
    210                 215                 220                 


Thr Pro Leu Met Ala Asp Asp Val Ala Asp Leu Ile Val Tyr Ala Thr 
225                 230                 235                 240 


Ser Arg Lys Gln Asn Thr Val Ile Ala Asp Thr Leu Ile Phe Pro Thr 
                245                 250                 255     


Asn Gln Ala Ser Pro His His Ile Phe Arg Gly 
            260                 265         


<210>  7
<211>  247
<212>  PRT
<213>  Escherichia coli

<400>  7

Met Ile Val Leu Val Thr Gly Ala Gly Gly Phe Gly Glu Cys Ile Thr 
1               5                   10                  15      


Arg Arg Phe Ile Gln Gln Gly His Lys Val Ile Ala Thr Asp Leu Asn 
            20                  25                  30          


Pro Ala Ala Leu Gln Glu Leu Lys Asp Glu Leu Gly Asp Asn Leu Tyr 
        35                  40                  45              


Ile Ala Gln Leu Asp Val Arg Asn Arg Ala Ala Ile Glu Glu Met Leu 
    50                  55                  60                  


Ala Ser Leu Pro Ala Glu Trp Cys Asn Ile Asp Ile Leu Val Asn Asn 
65                  70                  75                  80  


Ala Gly Leu Ala Leu Gly Met Glu Pro Ala His Lys Ala Ser Val Glu 
                85                  90                  95      


Asp Trp Glu Thr Met Ile Asp Thr Asn Asn Lys Gly Leu Val Tyr Met 
            100                 105                 110         


Thr Arg Ala Val Leu Pro Gly Met Val Glu Arg Asn His Gly His Ile 
        115                 120                 125             


Ile Asn Ile Gly Ser Thr Ala Gly Ser Trp Pro Tyr Ala Gly Gly Asn 
    130                 135                 140                 


Val Tyr Gly Ala Thr Lys Ala Phe Val Arg Gln Phe Ser Leu Asn Leu 
145                 150                 155                 160 


Arg Thr Asp Leu His Gly Thr Ala Val Arg Val Thr Asp Ile Glu Pro 
                165                 170                 175     


Gly Leu Val Gly Gly Thr Glu Phe Ser Asn Val Arg Phe Lys Gly Asp 
            180                 185                 190         


Asp Gly Lys Ala Glu Lys Thr Tyr Gln Asn Thr Val Ala Leu Thr Pro 
        195                 200                 205             


Glu Asp Val Ser Glu Ala Val Trp Trp Val Ser Thr Leu Pro Ala His 
    210                 215                 220                 


Val Asn Ile Asn Thr Leu Glu Met Met Pro Val Thr Gln Ser Tyr Ala 
225                 230                 235                 240 


Gly Leu Asn Val His Arg Gln 
                245         


<210>  8
<211>  248
<212>  PRT
<213>  Escherichia coli

<400>  8

Met Ile Val Leu Val Thr Gly Ala Gly Ala Gly Phe Gly Glu Cys Ile 
1               5                   10                  15      


Thr Arg Arg Phe Ile Gln Gln Gly His Lys Val Ile Ala Thr Glu Leu 
            20                  25                  30          


Asn Pro Ala Ala Leu Gln Glu Leu Lys Asp Glu Leu Gly Asp Asn Leu 
        35                  40                  45              


Tyr Ile Ala Gln Leu Asp Val Arg Asn Arg Ala Ala Ile Glu Glu Met 
    50                  55                  60                  


Leu Ala Ser Leu Pro Ala Glu Trp Cys Asn Ile Asp Ile Leu Val Asn 
65                  70                  75                  80  


Asn Ala Gly Leu Ala Leu Gly Met Glu Pro Ala His Lys Ala Ser Val 
                85                  90                  95      


Glu Asp Trp Glu Thr Met Ile Asp Thr Asn Asn Lys Gly Leu Val Tyr 
            100                 105                 110         


Met Thr Arg Ala Val Leu Pro Gly Met Val Glu Arg Asn His Gly His 
        115                 120                 125             


Ile Ile Asn Ile Gly Ser Thr Ala Gly Ser Trp Pro Tyr Ala Gly Gly 
    130                 135                 140                 


Asn Val Tyr Gly Ala Thr Lys Ala Phe Val Arg Gln Phe Ser Leu Asn 
145                 150                 155                 160 


Leu Arg Thr Asp Leu His Gly Thr Ala Val Arg Val Thr Asp Ile Glu 
                165                 170                 175     


Pro Gly Leu Val Gly Gly Thr Glu Phe Ser Asn Val Arg Phe Lys Gly 
            180                 185                 190         


Asp Asp Gly Lys Ala Glu Lys Thr Tyr Gln Asn Thr Val Ala Leu Thr 
        195                 200                 205             


Pro Glu Asp Val Ser Glu Ala Val Trp Trp Val Ser Thr Leu Pro Ala 
    210                 215                 220                 


His Val Asn Ile Asn Thr Leu Glu Met Met Pro Val Thr Gln Ser Tyr 
225                 230                 235                 240 


Ala Gly Leu Asn Val His Arg Gln 
                245             


<210>  9
<211>  247
<212>  PRT
<213>  Escherichia coli

<400>  9

Met Ile Val Leu Val Thr Gly Ala Gly Gly Phe Gly Glu Cys Ile Thr 
1               5                   10                  15      


Arg Arg Phe Ile Gln Gln Gly His Lys Val Ile Ala Thr Glu Leu Asn 
            20                  25                  30          


Pro Ala Ala Leu Gln Glu Leu Lys Asp Glu Leu Gly Asp Asn Leu Tyr 
        35                  40                  45              


Ile Ala Gln Leu Asp Val Arg Asn Arg Ala Ala Ile Glu Glu Met Leu 
    50                  55                  60                  


Ala Ser Leu Pro Ala Glu Trp Cys Asn Ile Asp Ile Leu Val Asn Asn 
65                  70                  75                  80  


Ala Gly Leu Ala Leu Gly Met Glu Pro Ala His Lys Ala Ser Val Glu 
                85                  90                  95      


Asp Trp Glu Thr Met Ile Asp Thr Asn Asn Lys Gly Leu Val Tyr Met 
            100                 105                 110         


Thr Arg Ala Val Leu Pro Gly Met Val Glu Arg Asn His Gly His Ile 
        115                 120                 125             


Ile Asn Ile Gly Ser Thr Ala Gly Ser Trp Pro Tyr Ala Gly Gly Asn 
    130                 135                 140                 


Val Tyr Gly Ala Thr Lys Ala Phe Val Arg Gln Phe Ser Leu Asn Leu 
145                 150                 155                 160 


Arg Thr Asp Leu His Gly Thr Ala Val Arg Val Thr Asp Ile Glu Pro 
                165                 170                 175     


Gly Leu Val Gly Gly Thr Glu Phe Ser Asn Val Arg Phe Lys Gly Asp 
            180                 185                 190         


Asp Gly Lys Ala Glu Lys Thr Tyr Gln Asn Thr Val Ala Leu Thr Pro 
        195                 200                 205             


Glu Asp Val Ser Glu Ala Val Trp Trp Val Ser Thr Leu Pro Ala His 
    210                 215                 220                 


Val Asn Ile Asn Thr Leu Glu Met Met Pro Val Thr Gln Ser Tyr Ala 
225                 230                 235                 240 


Gly Leu Asn Val His Arg Gln 
                245         


<210>  10
<211>  248
<212>  PRT
<213>  Escherichia coli

<400>  10

Met Ile Val Leu Val Thr Gly Ala Gly Ala Gly Phe Gly Glu Cys Ile 
1               5                   10                  15      


Thr Arg Arg Phe Ile Gln Gln Gly His Lys Val Ile Ala Thr Asp Leu 
            20                  25                  30          


Ser Ala Asp Ala Leu Gln Glu Leu Lys Asp Glu Leu Gly Asp Asn Leu 
        35                  40                  45              


Tyr Ile Ala Gln Leu Asp Val Arg Asn Arg Ala Ala Ile Glu Glu Met 
    50                  55                  60                  


Leu Ala Ser Leu Pro Ala Glu Trp Cys Asn Ile Asp Ile Leu Val Asn 
65                  70                  75                  80  


Asn Ala Gly Leu Ala Leu Gly Met Glu Pro Ala His Lys Ala Ser Val 
                85                  90                  95      


Glu Asp Trp Glu Thr Met Ile Asp Thr Asn Asn Lys Gly Leu Val Tyr 
            100                 105                 110         


Met Thr Arg Ala Val Leu Pro Gly Met Val Glu Arg Asn His Gly His 
        115                 120                 125             


Ile Ile Asn Ile Gly Ser Thr Ala Gly Ser Trp Pro Tyr Ala Gly Gly 
    130                 135                 140                 


Asn Val Tyr Gly Ala Thr Lys Ala Phe Val Arg Gln Phe Ser Leu Asn 
145                 150                 155                 160 


Leu Arg Thr Asp Leu His Gly Thr Ala Val Arg Val Thr Asp Ile Glu 
                165                 170                 175     


Pro Gly Leu Val Gly Gly Thr Glu Phe Ser Asn Val Arg Phe Lys Gly 
            180                 185                 190         


Asp Asp Gly Lys Ala Glu Lys Thr Tyr Gln Asn Thr Val Ala Leu Thr 
        195                 200                 205             


Pro Glu Asp Val Ser Glu Ala Val Trp Trp Val Ser Thr Leu Pro Ala 
    210                 215                 220                 


His Val Asn Ile Asn Thr Leu Glu Met Met Pro Val Thr Gln Ser Tyr 
225                 230                 235                 240 


Ala Gly Leu Asn Val His Arg Gln 
                245             


<210>  11
<211>  247
<212>  PRT
<213>  Escherichia coli

<400>  11

Met Ile Val Leu Val Thr Gly Ala Gly Gly Phe Gly Glu Cys Ile Thr 
1               5                   10                  15      


Arg Arg Phe Ile Gln Gln Gly His Lys Val Ile Ala Thr Asp Leu Ser 
            20                  25                  30          


Ala Asp Ala Leu Gln Glu Leu Lys Asp Glu Leu Gly Asp Asn Leu Tyr 
        35                  40                  45              


Ile Ala Gln Leu Asp Val Arg Asn Arg Ala Ala Ile Glu Glu Met Leu 
    50                  55                  60                  


Ala Ser Leu Pro Ala Glu Trp Cys Asn Ile Asp Ile Leu Val Asn Asn 
65                  70                  75                  80  


Ala Gly Leu Ala Leu Gly Met Glu Pro Ala His Lys Ala Ser Val Glu 
                85                  90                  95      


Asp Trp Glu Thr Met Ile Asp Thr Asn Asn Lys Gly Leu Val Tyr Met 
            100                 105                 110         


Thr Arg Ala Val Leu Pro Gly Met Val Glu Arg Asn His Gly His Ile 
        115                 120                 125             


Ile Asn Ile Gly Ser Thr Ala Gly Ser Trp Pro Tyr Ala Gly Gly Asn 
    130                 135                 140                 


Val Tyr Gly Ala Thr Lys Ala Phe Val Arg Gln Phe Ser Leu Asn Leu 
145                 150                 155                 160 


Arg Thr Asp Leu His Gly Thr Ala Val Arg Val Thr Asp Ile Glu Pro 
                165                 170                 175     


Gly Leu Val Gly Gly Thr Glu Phe Ser Asn Val Arg Phe Lys Gly Asp 
            180                 185                 190         


Asp Gly Lys Ala Glu Lys Thr Tyr Gln Asn Thr Val Ala Leu Thr Pro 
        195                 200                 205             


Glu Asp Val Ser Glu Ala Val Trp Trp Val Ser Thr Leu Pro Ala His 
    210                 215                 220                 


Val Asn Ile Asn Thr Leu Glu Met Met Pro Val Thr Gln Ser Tyr Ala 
225                 230                 235                 240 


Gly Leu Asn Val His Arg Gln 
                245         


<210>  12
<211>  248
<212>  PRT
<213>  Escherichia coli

<400>  12

Met Ile Val Leu Val Thr Gly Ala Gly Ala Gly Phe Gly Glu Cys Ile 
1               5                   10                  15      


Thr Arg Arg Phe Ile Gln Gln Gly His Lys Val Ile Ala Thr Asp Leu 
            20                  25                  30          


Asn Pro Ala Ala Leu Gln Glu Leu Lys Asp Glu Leu Gly Asp Asn Leu 
        35                  40                  45              


Tyr Ile Ala Gln Leu Asp Val Arg Asn Arg Ala Ala Ile Glu Glu Met 
    50                  55                  60                  


Leu Ala Ser Leu Pro Ala Glu Trp Cys Asn Ile Asp Ile Leu Val Asn 
65                  70                  75                  80  


Asn Ala Gly Leu Ala Leu Gly Met Glu Pro Ala His Lys Ala Ser Val 
                85                  90                  95      


Glu Asp Trp Glu Thr Met Ile Asp Thr Asn Asn Lys Gly Leu Val Tyr 
            100                 105                 110         


Met Thr Arg Ala Val Leu Pro Gly Met Val Glu Arg Asn His Gly His 
        115                 120                 125             


Ile Ile Asn Ile Gly Ser Thr Ala Gly Ser Trp Pro Tyr Ala Gly Gly 
    130                 135                 140                 


Asn Val Tyr Gly Ala Thr Lys Ala Phe Val Arg Gln Phe Ser Leu Asn 
145                 150                 155                 160 


Leu Arg Thr Asp Leu His Gly Thr Ala Val Arg Val Thr Asp Ile Glu 
                165                 170                 175     


Pro Gly Leu Val Gly Gly Thr Glu Phe Ser Asn Val Arg Phe Lys Gly 
            180                 185                 190         


Asp Asp Gly Lys Ala Glu Lys Thr Tyr Gln Asn Thr Val Ala Leu Thr 
        195                 200                 205             


Pro Glu Asp Val Ser Glu Ala Val Trp Trp Val Ser Thr Leu Pro Ala 
    210                 215                 220                 


His Val Asn Ile Asn Thr Leu Glu Met Met Pro Val Thr Gln Ser Tyr 
225                 230                 235                 240 


Ala Gly Leu Asn Val His Arg Gln 
                245             


<210>  13
<211>  247
<212>  PRT
<213>  Escherichia coli

<400>  13

Met Ile Val Leu Val Thr Gly Ala Gly Gly Phe Gly Glu Cys Ile Thr 
1               5                   10                  15      


Arg Arg Phe Ile Gln Gln Gly His Lys Val Ile Ala Thr Glu Leu Ser 
            20                  25                  30          


Ala Asp Ala Leu Gln Glu Leu Lys Asp Glu Leu Gly Asp Asn Leu Tyr 
        35                  40                  45              


Ile Ala Gln Leu Asp Val Arg Asn Arg Ala Ala Ile Glu Glu Met Leu 
    50                  55                  60                  


Ala Ser Leu Pro Ala Glu Trp Cys Asn Ile Asp Ile Leu Val Asn Asn 
65                  70                  75                  80  


Ala Gly Leu Ala Leu Gly Met Glu Pro Ala His Lys Ala Ser Val Glu 
                85                  90                  95      


Asp Trp Glu Thr Met Ile Asp Thr Asn Asn Lys Gly Leu Val Tyr Met 
            100                 105                 110         


Thr Arg Ala Val Leu Pro Gly Met Val Glu Arg Asn His Gly His Ile 
        115                 120                 125             


Ile Asn Ile Gly Ser Thr Ala Gly Ser Trp Pro Tyr Ala Gly Gly Asn 
    130                 135                 140                 


Val Tyr Gly Ala Thr Lys Ala Phe Val Arg Gln Phe Ser Leu Asn Leu 
145                 150                 155                 160 


Arg Thr Asp Leu His Gly Thr Ala Val Arg Val Thr Asp Ile Glu Pro 
                165                 170                 175     


Gly Leu Val Gly Gly Thr Glu Phe Ser Asn Val Arg Phe Lys Gly Asp 
            180                 185                 190         


Asp Gly Lys Ala Glu Lys Thr Tyr Gln Asn Thr Val Ala Leu Thr Pro 
        195                 200                 205             


Glu Asp Val Ser Glu Ala Val Trp Trp Val Ser Thr Leu Pro Ala His 
    210                 215                 220                 


Val Asn Ile Asn Thr Leu Glu Met Met Pro Val Thr Gln Ser Tyr Ala 
225                 230                 235                 240 


Gly Leu Asn Val His Arg Gln 
                245         


<210>  14
<211>  248
<212>  PRT
<213>  Escherichia coli

<400>  14

Met Ile Val Leu Val Thr Gly Ala Gly Ala Gly Phe Gly Glu Cys Ile 
1               5                   10                  15      


Thr Arg Arg Phe Ile Gln Gln Gly His Lys Val Ile Ala Thr Glu Leu 
            20                  25                  30          


Ser Ala Asp Ala Leu Gln Glu Leu Lys Asp Glu Leu Gly Asp Asn Leu 
        35                  40                  45              


Tyr Ile Ala Gln Leu Asp Val Arg Asn Arg Ala Ala Ile Glu Glu Met 
    50                  55                  60                  


Leu Ala Ser Leu Pro Ala Glu Trp Cys Asn Ile Asp Ile Leu Val Asn 
65                  70                  75                  80  


Asn Ala Gly Leu Ala Leu Gly Met Glu Pro Ala His Lys Ala Ser Val 
                85                  90                  95      


Glu Asp Trp Glu Thr Met Ile Asp Thr Asn Asn Lys Gly Leu Val Tyr 
            100                 105                 110         


Met Thr Arg Ala Val Leu Pro Gly Met Val Glu Arg Asn His Gly His 
        115                 120                 125             


Ile Ile Asn Ile Gly Ser Thr Ala Gly Ser Trp Pro Tyr Ala Gly Gly 
    130                 135                 140                 


Asn Val Tyr Gly Ala Thr Lys Ala Phe Val Arg Gln Phe Ser Leu Asn 
145                 150                 155                 160 


Leu Arg Thr Asp Leu His Gly Thr Ala Val Arg Val Thr Asp Ile Glu 
                165                 170                 175     


Pro Gly Leu Val Gly Gly Thr Glu Phe Ser Asn Val Arg Phe Lys Gly 
            180                 185                 190         


Asp Asp Gly Lys Ala Glu Lys Thr Tyr Gln Asn Thr Val Ala Leu Thr 
        195                 200                 205             


Pro Glu Asp Val Ser Glu Ala Val Trp Trp Val Ser Thr Leu Pro Ala 
    210                 215                 220                 


His Val Asn Ile Asn Thr Leu Glu Met Met Pro Val Thr Gln Ser Tyr 
225                 230                 235                 240 


Ala Gly Leu Asn Val His Arg Gln 
                245             


<210>  15
<211>  31
<212>  DNA
<213>  Escherichia coli

<400>  15
cggaattcat gatcgtttta gtaactggag c                                      31


<210>  16
<211>  29
<212>  DNA
<213>  Escherichia coli

<400>  16
cgggatcctt actgacggtg gacattcag                                         29


<210>  17
<211>  248
<212>  PRT
<213>  Escherichia coli

<400>  17

Met Ile Val Leu Val Thr Gly Ala Thr Ala Gly Phe Gly Glu Cys Ile 
1               5                   10                  15      


Thr Arg Arg Phe Ile Gln Gln Gly His Lys Val Ile Ala Thr Asp Leu 
            20                  25                  30          


Asn Pro Ala Ala Leu Gln Glu Leu Lys Asp Glu Leu Gly Asp Asn Leu 
        35                  40                  45              


Tyr Ile Ala Gln Leu Asp Val Arg Asn Arg Ala Ala Ile Glu Glu Met 
    50                  55                  60                  


Leu Ala Ser Leu Pro Ala Glu Trp Cys Asn Ile Asp Ile Leu Val Asn 
65                  70                  75                  80  


Asn Ala Gly Leu Ala Leu Gly Met Glu Pro Ala His Lys Ala Ser Val 
                85                  90                  95      


Glu Asp Trp Glu Thr Met Ile Asp Thr Asn Asn Lys Gly Leu Val Tyr 
            100                 105                 110         


Met Thr Arg Ala Val Leu Pro Gly Met Val Glu Arg Asn His Gly His 
        115                 120                 125             


Ile Ile Asn Ile Gly Ser Thr Ala Gly Ser Trp Pro Tyr Ala Gly Gly 
    130                 135                 140                 


Asn Val Tyr Gly Ala Thr Lys Ala Phe Val Arg Gln Phe Ser Leu Asn 
145                 150                 155                 160 


Leu Arg Thr Asp Leu His Gly Thr Ala Val Arg Val Thr Asp Ile Glu 
                165                 170                 175     


Pro Gly Leu Val Gly Gly Thr Glu Phe Ser Asn Val Arg Phe Lys Gly 
            180                 185                 190         


Asp Asp Gly Lys Ala Glu Lys Thr Tyr Gln Asn Thr Val Ala Leu Thr 
        195                 200                 205             


Pro Glu Asp Val Ser Glu Ala Val Trp Trp Val Ser Thr Leu Pro Ala 
    210                 215                 220                 


His Val Asn Ile Asn Thr Leu Glu Met Met Pro Val Thr Gln Ser Tyr 
225                 230                 235                 240 


Ala Gly Leu Asn Val His Arg Gln 
                245             


<210>  18
<211>  248
<212>  PRT
<213>  Escherichia coli

<400>  18

Met Ile Val Leu Val Thr Gly Ala Gly Ala Gly Phe Gly Glu Cys Ile 
1               5                   10                  15      


Thr Arg Arg Phe Ile Gln Gln Gly His Lys Val Ile Ala Thr Gly Leu 
            20                  25                  30          


Asn Pro Ala Ala Leu Gln Glu Leu Lys Asp Glu Leu Gly Asp Asn Leu 
        35                  40                  45              


Tyr Ile Ala Gln Leu Asp Val Arg Asn Arg Ala Ala Ile Glu Glu Met 
    50                  55                  60                  


Leu Ala Ser Leu Pro Ala Glu Trp Cys Asn Ile Asp Ile Leu Val Asn 
65                  70                  75                  80  


Asn Ala Gly Leu Ala Leu Gly Met Glu Pro Ala His Lys Ala Ser Val 
                85                  90                  95      


Glu Asp Trp Glu Thr Met Ile Asp Thr Asn Asn Lys Gly Leu Val Tyr 
            100                 105                 110         


Met Thr Arg Ala Val Leu Pro Gly Met Val Glu Arg Asn His Gly His 
        115                 120                 125             


Ile Ile Asn Ile Gly Ser Thr Ala Gly Ser Trp Pro Tyr Ala Gly Gly 
    130                 135                 140                 


Asn Val Tyr Gly Ala Thr Lys Ala Phe Val Arg Gln Phe Ser Leu Asn 
145                 150                 155                 160 


Leu Arg Thr Asp Leu His Gly Thr Ala Val Arg Val Thr Asp Ile Glu 
                165                 170                 175     


Pro Gly Leu Val Gly Gly Thr Glu Phe Ser Asn Val Arg Phe Lys Gly 
            180                 185                 190         


Asp Asp Gly Lys Ala Glu Lys Thr Tyr Gln Asn Thr Val Ala Leu Thr 
        195                 200                 205             


Pro Glu Asp Val Ser Glu Ala Val Trp Trp Val Ser Thr Leu Pro Ala 
    210                 215                 220                 


His Val Asn Ile Asn Thr Leu Glu Met Met Pro Val Thr Gln Ser Tyr 
225                 230                 235                 240 


Ala Gly Leu Asn Val His Arg Gln 
                245             


<210>  19
<211>  248
<212>  PRT
<213>  Escherichia coli

<400>  19

Met Ile Val Leu Val Thr Gly Ala Gly Ala Gly Phe Gly Glu Cys Ile 
1               5                   10                  15      


Thr Arg Arg Phe Ile Gln Gln Gly His Lys Val Ile Ala Thr Asp Arg 
            20                  25                  30          


Asn Pro Ala Ala Leu Gln Glu Leu Lys Asp Glu Leu Gly Asp Asn Leu 
        35                  40                  45              


Tyr Ile Ala Gln Leu Asp Val Arg Asn Arg Ala Ala Ile Glu Glu Met 
    50                  55                  60                  


Leu Ala Ser Leu Pro Ala Glu Trp Cys Asn Ile Asp Ile Leu Val Asn 
65                  70                  75                  80  


Asn Ala Gly Leu Ala Leu Gly Met Glu Pro Ala His Lys Ala Ser Val 
                85                  90                  95      


Glu Asp Trp Glu Thr Met Ile Asp Thr Asn Asn Lys Gly Leu Val Tyr 
            100                 105                 110         


Met Thr Arg Ala Val Leu Pro Gly Met Val Glu Arg Asn His Gly His 
        115                 120                 125             


Ile Ile Asn Ile Gly Ser Thr Ala Gly Ser Trp Pro Tyr Ala Gly Gly 
    130                 135                 140                 


Asn Val Tyr Gly Ala Thr Lys Ala Phe Val Arg Gln Phe Ser Leu Asn 
145                 150                 155                 160 


Leu Arg Thr Asp Leu His Gly Thr Ala Val Arg Val Thr Asp Ile Glu 
                165                 170                 175     


Pro Gly Leu Val Gly Gly Thr Glu Phe Ser Asn Val Arg Phe Lys Gly 
            180                 185                 190         


Asp Asp Gly Lys Ala Glu Lys Thr Tyr Gln Asn Thr Val Ala Leu Thr 
        195                 200                 205             


Pro Glu Asp Val Ser Glu Ala Val Trp Trp Val Ser Thr Leu Pro Ala 
    210                 215                 220                 


His Val Asn Ile Asn Thr Leu Glu Met Met Pro Val Thr Gln Ser Tyr 
225                 230                 235                 240 


Ala Gly Leu Asn Val His Arg Gln 
                245             


<210>  20
<211>  248
<212>  PRT
<213>  Escherichia coli

<400>  20

Met Ile Val Leu Val Thr Gly Ala Gly Ala Gly Phe Gly Glu Cys Ile 
1               5                   10                  15      


Thr Arg Arg Phe Ile Gln Gln Gly His Lys Val Ile Ala Thr Asp Leu 
            20                  25                  30          


Arg Pro Ala Ala Leu Gln Glu Leu Lys Asp Glu Leu Gly Asp Asn Leu 
        35                  40                  45              


Tyr Ile Ala Gln Leu Asp Val Arg Asn Arg Ala Ala Ile Glu Glu Met 
    50                  55                  60                  


Leu Ala Ser Leu Pro Ala Glu Trp Cys Asn Ile Asp Ile Leu Val Asn 
65                  70                  75                  80  


Asn Ala Gly Leu Ala Leu Gly Met Glu Pro Ala His Lys Ala Ser Val 
                85                  90                  95      


Glu Asp Trp Glu Thr Met Ile Asp Thr Asn Asn Lys Gly Leu Val Tyr 
            100                 105                 110         


Met Thr Arg Ala Val Leu Pro Gly Met Val Glu Arg Asn His Gly His 
        115                 120                 125             


Ile Ile Asn Ile Gly Ser Thr Ala Gly Ser Trp Pro Tyr Ala Gly Gly 
    130                 135                 140                 


Asn Val Tyr Gly Ala Thr Lys Ala Phe Val Arg Gln Phe Ser Leu Asn 
145                 150                 155                 160 


Leu Arg Thr Asp Leu His Gly Thr Ala Val Arg Val Thr Asp Ile Glu 
                165                 170                 175     


Pro Gly Leu Val Gly Gly Thr Glu Phe Ser Asn Val Arg Phe Lys Gly 
            180                 185                 190         


Asp Asp Gly Lys Ala Glu Lys Thr Tyr Gln Asn Thr Val Ala Leu Thr 
        195                 200                 205             


Pro Glu Asp Val Ser Glu Ala Val Trp Trp Val Ser Thr Leu Pro Ala 
    210                 215                 220                 


His Val Asn Ile Asn Thr Leu Glu Met Met Pro Val Thr Gln Ser Tyr 
225                 230                 235                 240 


Ala Gly Leu Asn Val His Arg Gln 
                245             


<210>  21
<211>  248
<212>  PRT
<213>  Escherichia coli

<400>  21

Met Ile Val Leu Val Thr Gly Ala Gly Ala Gly Phe Gly Glu Cys Ile 
1               5                   10                  15      


Thr Arg Arg Phe Ile Gln Gln Gly His Lys Val Ile Ala Thr Asp Leu 
            20                  25                  30          


Asn Gln Ala Ala Leu Gln Glu Leu Lys Asp Glu Leu Gly Asp Asn Leu 
        35                  40                  45              


Tyr Ile Ala Gln Leu Asp Val Arg Asn Arg Ala Ala Ile Glu Glu Met 
    50                  55                  60                  


Leu Ala Ser Leu Pro Ala Glu Trp Cys Asn Ile Asp Ile Leu Val Asn 
65                  70                  75                  80  


Asn Ala Gly Leu Ala Leu Gly Met Glu Pro Ala His Lys Ala Ser Val 
                85                  90                  95      


Glu Asp Trp Glu Thr Met Ile Asp Thr Asn Asn Lys Gly Leu Val Tyr 
            100                 105                 110         


Met Thr Arg Ala Val Leu Pro Gly Met Val Glu Arg Asn His Gly His 
        115                 120                 125             


Ile Ile Asn Ile Gly Ser Thr Ala Gly Ser Trp Pro Tyr Ala Gly Gly 
    130                 135                 140                 


Asn Val Tyr Gly Ala Thr Lys Ala Phe Val Arg Gln Phe Ser Leu Asn 
145                 150                 155                 160 


Leu Arg Thr Asp Leu His Gly Thr Ala Val Arg Val Thr Asp Ile Glu 
                165                 170                 175     


Pro Gly Leu Val Gly Gly Thr Glu Phe Ser Asn Val Arg Phe Lys Gly 
            180                 185                 190         


Asp Asp Gly Lys Ala Glu Lys Thr Tyr Gln Asn Thr Val Ala Leu Thr 
        195                 200                 205             


Pro Glu Asp Val Ser Glu Ala Val Trp Trp Val Ser Thr Leu Pro Ala 
    210                 215                 220                 


His Val Asn Ile Asn Thr Leu Glu Met Met Pro Val Thr Gln Ser Tyr 
225                 230                 235                 240 


Ala Gly Leu Asn Val His Arg Gln 
                245             


<210>  22
<211>  248
<212>  PRT
<213>  Escherichia coli

<400>  22

Met Ile Val Leu Val Thr Gly Ala Gly Ala Gly Phe Gly Glu Cys Ile 
1               5                   10                  15      


Thr Arg Arg Phe Ile Gln Gln Gly His Lys Val Ile Ala Thr Asp Leu 
            20                  25                  30          


Asn Pro Glu Ala Leu Gln Glu Leu Lys Asp Glu Leu Gly Asp Asn Leu 
        35                  40                  45              


Tyr Ile Ala Gln Leu Asp Val Arg Asn Arg Ala Ala Ile Glu Glu Met 
    50                  55                  60                  


Leu Ala Ser Leu Pro Ala Glu Trp Cys Asn Ile Asp Ile Leu Val Asn 
65                  70                  75                  80  


Asn Ala Gly Leu Ala Leu Gly Met Glu Pro Ala His Lys Ala Ser Val 
                85                  90                  95      


Glu Asp Trp Glu Thr Met Ile Asp Thr Asn Asn Lys Gly Leu Val Tyr 
            100                 105                 110         


Met Thr Arg Ala Val Leu Pro Gly Met Val Glu Arg Asn His Gly His 
        115                 120                 125             


Ile Ile Asn Ile Gly Ser Thr Ala Gly Ser Trp Pro Tyr Ala Gly Gly 
    130                 135                 140                 


Asn Val Tyr Gly Ala Thr Lys Ala Phe Val Arg Gln Phe Ser Leu Asn 
145                 150                 155                 160 


Leu Arg Thr Asp Leu His Gly Thr Ala Val Arg Val Thr Asp Ile Glu 
                165                 170                 175     


Pro Gly Leu Val Gly Gly Thr Glu Phe Ser Asn Val Arg Phe Lys Gly 
            180                 185                 190         


Asp Asp Gly Lys Ala Glu Lys Thr Tyr Gln Asn Thr Val Ala Leu Thr 
        195                 200                 205             


Pro Glu Asp Val Ser Glu Ala Val Trp Trp Val Ser Thr Leu Pro Ala 
    210                 215                 220                 


His Val Asn Ile Asn Thr Leu Glu Met Met Pro Val Thr Gln Ser Tyr 
225                 230                 235                 240 


Ala Gly Leu Asn Val His Arg Gln 
                245             


<210>  23
<211>  248
<212>  PRT
<213>  Escherichia coli

<400>  23

Met Ile Val Leu Val Thr Gly Ala Gly Ala Gly Phe Gly Glu Cys Ile 
1               5                   10                  15      


Thr Arg Arg Phe Ile Gln Gln Gly His Lys Val Ile Ala Thr Asp Leu 
            20                  25                  30          


Asn Pro Ala Arg Leu Gln Glu Leu Lys Asp Glu Leu Gly Asp Asn Leu 
        35                  40                  45              


Tyr Ile Ala Gln Leu Asp Val Arg Asn Arg Ala Ala Ile Glu Glu Met 
    50                  55                  60                  


Leu Ala Ser Leu Pro Ala Glu Trp Cys Asn Ile Asp Ile Leu Val Asn 
65                  70                  75                  80  


Asn Ala Gly Leu Ala Leu Gly Met Glu Pro Ala His Lys Ala Ser Val 
                85                  90                  95      


Glu Asp Trp Glu Thr Met Ile Asp Thr Asn Asn Lys Gly Leu Val Tyr 
            100                 105                 110         


Met Thr Arg Ala Val Leu Pro Gly Met Val Glu Arg Asn His Gly His 
        115                 120                 125             


Ile Ile Asn Ile Gly Ser Thr Ala Gly Ser Trp Pro Tyr Ala Gly Gly 
    130                 135                 140                 


Asn Val Tyr Gly Ala Thr Lys Ala Phe Val Arg Gln Phe Ser Leu Asn 
145                 150                 155                 160 


Leu Arg Thr Asp Leu His Gly Thr Ala Val Arg Val Thr Asp Ile Glu 
                165                 170                 175     


Pro Gly Leu Val Gly Gly Thr Glu Phe Ser Asn Val Arg Phe Lys Gly 
            180                 185                 190         


Asp Asp Gly Lys Ala Glu Lys Thr Tyr Gln Asn Thr Val Ala Leu Thr 
        195                 200                 205             


Pro Glu Asp Val Ser Glu Ala Val Trp Trp Val Ser Thr Leu Pro Ala 
    210                 215                 220                 


His Val Asn Ile Asn Thr Leu Glu Met Met Pro Val Thr Gln Ser Tyr 
225                 230                 235                 240 


Ala Gly Leu Asn Val His Arg Gln 
                245             


<210>  24
<211>  248
<212>  PRT
<213>  Escherichia coli

<400>  24

Met Ile Val Leu Val Thr Gly Ala Gly Ala Gly Phe Gly Glu Cys Ile 
1               5                   10                  15      


Thr Arg Arg Phe Ile Gln Gln Gly His Lys Val Ile Ala Thr Asp Leu 
            20                  25                  30          


Arg Gln Glu Ala Leu Gln Glu Leu Lys Asp Glu Leu Gly Asp Asn Leu 
        35                  40                  45              


Tyr Ile Ala Gln Leu Asp Val Arg Asn Arg Ala Ala Ile Glu Glu Met 
    50                  55                  60                  


Leu Ala Ser Leu Pro Ala Glu Trp Cys Asn Ile Asp Ile Leu Val Asn 
65                  70                  75                  80  


Asn Ala Gly Leu Ala Leu Gly Met Glu Pro Ala His Lys Ala Ser Val 
                85                  90                  95      


Glu Asp Trp Glu Thr Met Ile Asp Thr Asn Asn Lys Gly Leu Val Tyr 
            100                 105                 110         


Met Thr Arg Ala Val Leu Pro Gly Met Val Glu Arg Asn His Gly His 
        115                 120                 125             


Ile Ile Asn Ile Gly Ser Thr Ala Gly Ser Trp Pro Tyr Ala Gly Gly 
    130                 135                 140                 


Asn Val Tyr Gly Ala Thr Lys Ala Phe Val Arg Gln Phe Ser Leu Asn 
145                 150                 155                 160 


Leu Arg Thr Asp Leu His Gly Thr Ala Val Arg Val Thr Asp Ile Glu 
                165                 170                 175     


Pro Gly Leu Val Gly Gly Thr Glu Phe Ser Asn Val Arg Phe Lys Gly 
            180                 185                 190         


Asp Asp Gly Lys Ala Glu Lys Thr Tyr Gln Asn Thr Val Ala Leu Thr 
        195                 200                 205             


Pro Glu Asp Val Ser Glu Ala Val Trp Trp Val Ser Thr Leu Pro Ala 
    210                 215                 220                 


His Val Asn Ile Asn Thr Leu Glu Met Met Pro Val Thr Gln Ser Tyr 
225                 230                 235                 240 


Ala Gly Leu Asn Val His Arg Gln 
                245             


<210>  25
<211>  248
<212>  PRT
<213>  Escherichia coli

<400>  25

Met Ile Val Leu Val Thr Gly Ala Gly Ala Gly Phe Gly Glu Cys Ile 
1               5                   10                  15      


Thr Arg Arg Phe Ile Gln Gln Gly His Lys Val Ile Ala Thr Asp Leu 
            20                  25                  30          


Arg Gln Ala Ala Leu Gln Glu Leu Lys Asp Glu Leu Gly Asp Asn Leu 
        35                  40                  45              


Tyr Ile Ala Gln Leu Asp Val Arg Asn Arg Ala Ala Ile Glu Glu Met 
    50                  55                  60                  


Leu Ala Ser Leu Pro Ala Glu Trp Cys Asn Ile Asp Ile Leu Val Asn 
65                  70                  75                  80  


Asn Ala Gly Leu Ala Leu Gly Met Glu Pro Ala His Lys Ala Ser Val 
                85                  90                  95      


Glu Asp Trp Glu Thr Met Ile Asp Thr Asn Asn Lys Gly Leu Val Tyr 
            100                 105                 110         


Met Thr Arg Ala Val Leu Pro Gly Met Val Glu Arg Asn His Gly His 
        115                 120                 125             


Ile Ile Asn Ile Gly Ser Thr Ala Gly Ser Trp Pro Tyr Ala Gly Gly 
    130                 135                 140                 


Asn Val Tyr Gly Ala Thr Lys Ala Phe Val Arg Gln Phe Ser Leu Asn 
145                 150                 155                 160 


Leu Arg Thr Asp Leu His Gly Thr Ala Val Arg Val Thr Asp Ile Glu 
                165                 170                 175     


Pro Gly Leu Val Gly Gly Thr Glu Phe Ser Asn Val Arg Phe Lys Gly 
            180                 185                 190         


Asp Asp Gly Lys Ala Glu Lys Thr Tyr Gln Asn Thr Val Ala Leu Thr 
        195                 200                 205             


Pro Glu Asp Val Ser Glu Ala Val Trp Trp Val Ser Thr Leu Pro Ala 
    210                 215                 220                 


His Val Asn Ile Asn Thr Leu Glu Met Met Pro Val Thr Gln Ser Tyr 
225                 230                 235                 240 


Ala Gly Leu Asn Val His Arg Gln 
                245             


<210>  26
<211>  248
<212>  PRT
<213>  Escherichia coli

<400>  26

Met Ile Val Leu Val Thr Gly Ala Gly Ala Gly Phe Gly Glu Cys Ile 
1               5                   10                  15      


Thr Arg Arg Phe Ile Gln Gln Gly His Lys Val Ile Ala Thr Asp Leu 
            20                  25                  30          


Arg Pro Glu Ala Leu Gln Glu Leu Lys Asp Glu Leu Gly Asp Asn Leu 
        35                  40                  45              


Tyr Ile Ala Gln Leu Asp Val Arg Asn Arg Ala Ala Ile Glu Glu Met 
    50                  55                  60                  


Leu Ala Ser Leu Pro Ala Glu Trp Cys Asn Ile Asp Ile Leu Val Asn 
65                  70                  75                  80  


Asn Ala Gly Leu Ala Leu Gly Met Glu Pro Ala His Lys Ala Ser Val 
                85                  90                  95      


Glu Asp Trp Glu Thr Met Ile Asp Thr Asn Asn Lys Gly Leu Val Tyr 
            100                 105                 110         


Met Thr Arg Ala Val Leu Pro Gly Met Val Glu Arg Asn His Gly His 
        115                 120                 125             


Ile Ile Asn Ile Gly Ser Thr Ala Gly Ser Trp Pro Tyr Ala Gly Gly 
    130                 135                 140                 


Asn Val Tyr Gly Ala Thr Lys Ala Phe Val Arg Gln Phe Ser Leu Asn 
145                 150                 155                 160 


Leu Arg Thr Asp Leu His Gly Thr Ala Val Arg Val Thr Asp Ile Glu 
                165                 170                 175     


Pro Gly Leu Val Gly Gly Thr Glu Phe Ser Asn Val Arg Phe Lys Gly 
            180                 185                 190         


Asp Asp Gly Lys Ala Glu Lys Thr Tyr Gln Asn Thr Val Ala Leu Thr 
        195                 200                 205             


Pro Glu Asp Val Ser Glu Ala Val Trp Trp Val Ser Thr Leu Pro Ala 
    210                 215                 220                 


His Val Asn Ile Asn Thr Leu Glu Met Met Pro Val Thr Gln Ser Tyr 
225                 230                 235                 240 


Ala Gly Leu Asn Val His Arg Gln 
                245             


<210>  27
<211>  248
<212>  PRT
<213>  Escherichia coli

<400>  27

Met Ile Val Leu Val Thr Gly Ala Gly Ala Gly Phe Gly Glu Cys Ile 
1               5                   10                  15      


Thr Arg Arg Phe Ile Gln Gln Gly His Lys Val Ile Ala Thr Asp Leu 
            20                  25                  30          


Asn Gln Glu Ala Leu Gln Glu Leu Lys Asp Glu Leu Gly Asp Asn Leu 
        35                  40                  45              


Tyr Ile Ala Gln Leu Asp Val Arg Asn Arg Ala Ala Ile Glu Glu Met 
    50                  55                  60                  


Leu Ala Ser Leu Pro Ala Glu Trp Cys Asn Ile Asp Ile Leu Val Asn 
65                  70                  75                  80  


Asn Ala Gly Leu Ala Leu Gly Met Glu Pro Ala His Lys Ala Ser Val 
                85                  90                  95      


Glu Asp Trp Glu Thr Met Ile Asp Thr Asn Asn Lys Gly Leu Val Tyr 
            100                 105                 110         


Met Thr Arg Ala Val Leu Pro Gly Met Val Glu Arg Asn His Gly His 
        115                 120                 125             


Ile Ile Asn Ile Gly Ser Thr Ala Gly Ser Trp Pro Tyr Ala Gly Gly 
    130                 135                 140                 


Asn Val Tyr Gly Ala Thr Lys Ala Phe Val Arg Gln Phe Ser Leu Asn 
145                 150                 155                 160 


Leu Arg Thr Asp Leu His Gly Thr Ala Val Arg Val Thr Asp Ile Glu 
                165                 170                 175     


Pro Gly Leu Val Gly Gly Thr Glu Phe Ser Asn Val Arg Phe Lys Gly 
            180                 185                 190         


Asp Asp Gly Lys Ala Glu Lys Thr Tyr Gln Asn Thr Val Ala Leu Thr 
        195                 200                 205             


Pro Glu Asp Val Ser Glu Ala Val Trp Trp Val Ser Thr Leu Pro Ala 
    210                 215                 220                 


His Val Asn Ile Asn Thr Leu Glu Met Met Pro Val Thr Gln Ser Tyr 
225                 230                 235                 240 


Ala Gly Leu Asn Val His Arg Gln 
                245             


<210>  28
<211>  248
<212>  PRT
<213>  Escherichia coli

<400>  28

Met Ile Val Leu Val Thr Gly Ala Thr Ala Gly Phe Gly Glu Cys Ile 
1               5                   10                  15      


Thr Arg Arg Phe Ile Gln Gln Gly His Lys Val Ile Ala Thr Asp Arg 
            20                  25                  30          


Arg Gln Glu Arg Leu Gln Glu Leu Lys Asp Glu Leu Gly Asp Asn Leu 
        35                  40                  45              


Tyr Ile Ala Gln Leu Asp Val Arg Asn Arg Ala Ala Ile Glu Glu Met 
    50                  55                  60                  


Leu Ala Ser Leu Pro Ala Glu Trp Cys Asn Ile Asp Ile Leu Val Asn 
65                  70                  75                  80  


Asn Ala Gly Leu Ala Leu Gly Met Glu Pro Ala His Lys Ala Ser Val 
                85                  90                  95      


Glu Asp Trp Glu Thr Met Ile Asp Thr Asn Asn Lys Gly Leu Val Tyr 
            100                 105                 110         


Met Thr Arg Ala Val Leu Pro Gly Met Val Glu Arg Asn His Gly His 
        115                 120                 125             


Ile Ile Asn Ile Gly Ser Thr Ala Gly Ser Trp Pro Tyr Ala Gly Gly 
    130                 135                 140                 


Asn Val Tyr Gly Ala Thr Lys Ala Phe Val Arg Gln Phe Ser Leu Asn 
145                 150                 155                 160 


Leu Arg Thr Asp Leu His Gly Thr Ala Val Arg Val Thr Asp Ile Glu 
                165                 170                 175     


Pro Gly Leu Val Gly Gly Thr Glu Phe Ser Asn Val Arg Phe Lys Gly 
            180                 185                 190         


Asp Asp Gly Lys Ala Glu Lys Thr Tyr Gln Asn Thr Val Ala Leu Thr 
        195                 200                 205             


Pro Glu Asp Val Ser Glu Ala Val Trp Trp Val Ser Thr Leu Pro Ala 
    210                 215                 220                 


His Val Asn Ile Asn Thr Leu Glu Met Met Pro Val Thr Gln Ser Tyr 
225                 230                 235                 240 


Ala Gly Leu Asn Val His Arg Gln 
                245             


<210>  29
<211>  248
<212>  PRT
<213>  Escherichia coli

<400>  29

Met Ile Val Leu Val Thr Gly Ala Gly Ala Gly Phe Gly Glu Cys Ile 
1               5                   10                  15      


Thr Arg Arg Phe Ile Gln Gln Gly His Lys Val Ile Ala Thr Asp Arg 
            20                  25                  30          


Arg Gln Glu Ala Leu Gln Glu Leu Lys Asp Glu Leu Gly Asp Asn Leu 
        35                  40                  45              


Tyr Ile Ala Gln Leu Asp Val Arg Asn Arg Ala Ala Ile Glu Glu Met 
    50                  55                  60                  


Leu Ala Ser Leu Pro Ala Glu Trp Cys Asn Ile Asp Ile Leu Val Asn 
65                  70                  75                  80  


Asn Ala Gly Leu Ala Leu Gly Met Glu Pro Ala His Lys Ala Ser Val 
                85                  90                  95      


Glu Asp Trp Glu Thr Met Ile Asp Thr Asn Asn Lys Gly Leu Val Tyr 
            100                 105                 110         


Met Thr Arg Ala Val Leu Pro Gly Met Val Glu Arg Asn His Gly His 
        115                 120                 125             


Ile Ile Asn Ile Gly Ser Thr Ala Gly Ser Trp Pro Tyr Ala Gly Gly 
    130                 135                 140                 


Asn Val Tyr Gly Ala Thr Lys Ala Phe Val Arg Gln Phe Ser Leu Asn 
145                 150                 155                 160 


Leu Arg Thr Asp Leu His Gly Thr Ala Val Arg Val Thr Asp Ile Glu 
                165                 170                 175     


Pro Gly Leu Val Gly Gly Thr Glu Phe Ser Asn Val Arg Phe Lys Gly 
            180                 185                 190         


Asp Asp Gly Lys Ala Glu Lys Thr Tyr Gln Asn Thr Val Ala Leu Thr 
        195                 200                 205             


Pro Glu Asp Val Ser Glu Ala Val Trp Trp Val Ser Thr Leu Pro Ala 
    210                 215                 220                 


His Val Asn Ile Asn Thr Leu Glu Met Met Pro Val Thr Gln Ser Tyr 
225                 230                 235                 240 


Ala Gly Leu Asn Val His Arg Gln 
                245             


<210>  30
<211>  248
<212>  PRT
<213>  Escherichia coli

<400>  30

Met Ile Val Leu Val Thr Gly Ala Gly Ala Gly Phe Gly Glu Cys Ile 
1               5                   10                  15      


Thr Arg Arg Phe Ile Gln Gln Gly His Lys Val Ile Ala Thr Asp Leu 
            20                  25                  30          


Arg Gln Glu Arg Leu Gln Glu Leu Lys Asp Glu Leu Gly Asp Asn Leu 
        35                  40                  45              


Tyr Ile Ala Gln Leu Asp Val Arg Asn Arg Ala Ala Ile Glu Glu Met 
    50                  55                  60                  


Leu Ala Ser Leu Pro Ala Glu Trp Cys Asn Ile Asp Ile Leu Val Asn 
65                  70                  75                  80  


Asn Ala Gly Leu Ala Leu Gly Met Glu Pro Ala His Lys Ala Ser Val 
                85                  90                  95      


Glu Asp Trp Glu Thr Met Ile Asp Thr Asn Asn Lys Gly Leu Val Tyr 
            100                 105                 110         


Met Thr Arg Ala Val Leu Pro Gly Met Val Glu Arg Asn His Gly His 
        115                 120                 125             


Ile Ile Asn Ile Gly Ser Thr Ala Gly Ser Trp Pro Tyr Ala Gly Gly 
    130                 135                 140                 


Asn Val Tyr Gly Ala Thr Lys Ala Phe Val Arg Gln Phe Ser Leu Asn 
145                 150                 155                 160 


Leu Arg Thr Asp Leu His Gly Thr Ala Val Arg Val Thr Asp Ile Glu 
                165                 170                 175     


Pro Gly Leu Val Gly Gly Thr Glu Phe Ser Asn Val Arg Phe Lys Gly 
            180                 185                 190         


Asp Asp Gly Lys Ala Glu Lys Thr Tyr Gln Asn Thr Val Ala Leu Thr 
        195                 200                 205             


Pro Glu Asp Val Ser Glu Ala Val Trp Trp Val Ser Thr Leu Pro Ala 
    210                 215                 220                 


His Val Asn Ile Asn Thr Leu Glu Met Met Pro Val Thr Gln Ser Tyr 
225                 230                 235                 240 


Ala Gly Leu Asn Val His Arg Gln 
                245             


<210>  31
<211>  248
<212>  PRT
<213>  Escherichia coli

<400>  31

Met Ile Val Leu Val Thr Gly Ala Gly Ala Gly Phe Gly Glu Cys Ile 
1               5                   10                  15      


Thr Arg Arg Phe Ile Gln Gln Gly His Lys Val Ile Ala Thr Gly Arg 
            20                  25                  30          


Arg Gln Glu Arg Leu Gln Glu Leu Lys Asp Glu Leu Gly Asp Asn Leu 
        35                  40                  45              


Tyr Ile Ala Gln Leu Asp Val Arg Asn Arg Ala Ala Ile Glu Glu Met 
    50                  55                  60                  


Leu Ala Ser Leu Pro Ala Glu Trp Cys Asn Ile Asp Ile Leu Val Asn 
65                  70                  75                  80  


Asn Ala Gly Leu Ala Leu Gly Met Glu Pro Ala His Lys Ala Ser Val 
                85                  90                  95      


Glu Asp Trp Glu Thr Met Ile Asp Thr Asn Asn Lys Gly Leu Val Tyr 
            100                 105                 110         


Met Thr Arg Ala Val Leu Pro Gly Met Val Glu Arg Asn His Gly His 
        115                 120                 125             


Ile Ile Asn Ile Gly Ser Thr Ala Gly Ser Trp Pro Tyr Ala Gly Gly 
    130                 135                 140                 


Asn Val Tyr Gly Ala Thr Lys Ala Phe Val Arg Gln Phe Ser Leu Asn 
145                 150                 155                 160 


Leu Arg Thr Asp Leu His Gly Thr Ala Val Arg Val Thr Asp Ile Glu 
                165                 170                 175     


Pro Gly Leu Val Gly Gly Thr Glu Phe Ser Asn Val Arg Phe Lys Gly 
            180                 185                 190         


Asp Asp Gly Lys Ala Glu Lys Thr Tyr Gln Asn Thr Val Ala Leu Thr 
        195                 200                 205             


Pro Glu Asp Val Ser Glu Ala Val Trp Trp Val Ser Thr Leu Pro Ala 
    210                 215                 220                 


His Val Asn Ile Asn Thr Leu Glu Met Met Pro Val Thr Gln Ser Tyr 
225                 230                 235                 240 


Ala Gly Leu Asn Val His Arg Gln 
                245             


<210>  32
<211>  248
<212>  PRT
<213>  Escherichia coli

<400>  32

Met Ile Val Leu Val Thr Gly Ala Gly Ala Gly Phe Gly Glu Cys Ile 
1               5                   10                  15      


Thr Arg Arg Phe Ile Gln Gln Gly His Lys Val Ile Ala Thr Asp Arg 
            20                  25                  30          


Arg Gln Glu Arg Leu Gln Glu Leu Lys Asp Glu Leu Gly Asp Asn Leu 
        35                  40                  45              


Tyr Ile Ala Gln Leu Asp Val Arg Asn Arg Ala Ala Ile Glu Glu Met 
    50                  55                  60                  


Leu Ala Ser Leu Pro Ala Glu Trp Cys Asn Ile Asp Ile Leu Val Asn 
65                  70                  75                  80  


Asn Ala Gly Leu Ala Leu Gly Met Glu Pro Ala His Lys Ala Ser Val 
                85                  90                  95      


Glu Asp Trp Glu Thr Met Ile Asp Thr Asn Asn Lys Gly Leu Val Tyr 
            100                 105                 110         


Met Thr Arg Ala Val Leu Pro Gly Met Val Glu Arg Asn His Gly His 
        115                 120                 125             


Ile Ile Asn Ile Gly Ser Thr Ala Gly Ser Trp Pro Tyr Ala Gly Gly 
    130                 135                 140                 


Asn Val Tyr Gly Ala Thr Lys Ala Phe Val Arg Gln Phe Ser Leu Asn 
145                 150                 155                 160 


Leu Arg Thr Asp Leu His Gly Thr Ala Val Arg Val Thr Asp Ile Glu 
                165                 170                 175     


Pro Gly Leu Val Gly Gly Thr Glu Phe Ser Asn Val Arg Phe Lys Gly 
            180                 185                 190         


Asp Asp Gly Lys Ala Glu Lys Thr Tyr Gln Asn Thr Val Ala Leu Thr 
        195                 200                 205             


Pro Glu Asp Val Ser Glu Ala Val Trp Trp Val Ser Thr Leu Pro Ala 
    210                 215                 220                 


His Val Asn Ile Asn Thr Leu Glu Met Met Pro Val Thr Gln Ser Tyr 
225                 230                 235                 240 


Ala Gly Leu Asn Val His Arg Gln 
                245             


<210>  33
<211>  248
<212>  PRT
<213>  Escherichia coli

<400>  33

Met Ile Val Leu Val Thr Gly Ala Thr Ala Gly Phe Gly Glu Cys Ile 
1               5                   10                  15      


Thr Arg Arg Phe Ile Gln Gln Gly His Lys Val Ile Ala Thr Asp Leu 
            20                  25                  30          


Arg Gln Glu Arg Leu Gln Glu Leu Lys Asp Glu Leu Gly Asp Asn Leu 
        35                  40                  45              


Tyr Ile Ala Gln Leu Asp Val Arg Asn Arg Ala Ala Ile Glu Glu Met 
    50                  55                  60                  


Leu Ala Ser Leu Pro Ala Glu Trp Cys Asn Ile Asp Ile Leu Val Asn 
65                  70                  75                  80  


Asn Ala Gly Leu Ala Leu Gly Met Glu Pro Ala His Lys Ala Ser Val 
                85                  90                  95      


Glu Asp Trp Glu Thr Met Ile Asp Thr Asn Asn Lys Gly Leu Val Tyr 
            100                 105                 110         


Met Thr Arg Ala Val Leu Pro Gly Met Val Glu Arg Asn His Gly His 
        115                 120                 125             


Ile Ile Asn Ile Gly Ser Thr Ala Gly Ser Trp Pro Tyr Ala Gly Gly 
    130                 135                 140                 


Asn Val Tyr Gly Ala Thr Lys Ala Phe Val Arg Gln Phe Ser Leu Asn 
145                 150                 155                 160 


Leu Arg Thr Asp Leu His Gly Thr Ala Val Arg Val Thr Asp Ile Glu 
                165                 170                 175     


Pro Gly Leu Val Gly Gly Thr Glu Phe Ser Asn Val Arg Phe Lys Gly 
            180                 185                 190         


Asp Asp Gly Lys Ala Glu Lys Thr Tyr Gln Asn Thr Val Ala Leu Thr 
        195                 200                 205             


Pro Glu Asp Val Ser Glu Ala Val Trp Trp Val Ser Thr Leu Pro Ala 
    210                 215                 220                 


His Val Asn Ile Asn Thr Leu Glu Met Met Pro Val Thr Gln Ser Tyr 
225                 230                 235                 240 


Ala Gly Leu Asn Val His Arg Gln 
                245             


<210>  34
<211>  43
<212>  DNA
<213>  Escherichia coli

<400>  34
tcgccactga tctgaacccg gaagcgttgc aggagttaaa aga                         43


<210>  35
<211>  43
<212>  DNA
<213>  Escherichia coli

<400>  35
tcttttaact cctgcaacgc ttccgggttc agatcagtgg cga                         43


<210>  36
<211>  43
<212>  DNA
<213>  Escherichia coli

<400>  36
ccactgatct gaacccggcc cggttgcagg agttaaaaga cga                         43


<210>  37
<211>  43
<212>  DNA
<213>  Escherichia coli

<400>  37
tcgtctttta actcctgcaa ccgggccggg ttcagatcag tgg                         43


<210>  38
<211>  43
<212>  DNA
<213>  Escherichia coli

<400>  38
ggcataaagt tatcgccact ggcctgaacc cggccgcgtt gca                         43


<210>  39
<211>  43
<212>  DNA
<213>  Escherichia coli

<400>  39
tgcaacgcgg ccgggttcag gccagtggcg ataactttat gcc                         43


<210>  40
<211>  44
<212>  DNA
<213>  Escherichia coli

<400>  40
tcgttttagt aactggagca acggcaggtt ttggtgaatg catt                        44


<210>  41
<211>  44
<212>  DNA
<213>  Escherichia coli

<400>  41
aatgcattca ccaaaacctg ccgttgctcc agttactaaa acga                        44


<210>  42
<211>  43
<212>  DNA
<213>  Escherichia coli

<400>  42
ataaagttat cgccactgat cgtaacccgg ccgcgttgca gga                         43


<210>  43
<211>  43
<212>  DNA
<213>  Escherichia coli

<400>  43
tcctgcaacg cggccgggtt acgatcagtg gcgataactt tat                         43


<210>  44
<211>  43
<212>  DNA
<213>  Escherichia coli

<400>  44
aactcctgca acgcggccgg gcgcagatca gtggcgataa ctt                         43


<210>  45
<211>  43
<212>  DNA
<213>  Escherichia coli

<400>  45
aagttatcgc cactgatctg cgcccggccg cgttgcagga gtt                         43


<210>  46
<211>  43
<212>  DNA
<213>  Escherichia coli

<400>  46
ttatcgccac tgatctgaac caggccgcgt tgcaggagtt aaa                         43


<210>  47
<211>  43
<212>  DNA
<213>  Escherichia coli

<400>  47
tttaactcct gcaacgcggc ctggttcaga tcagtggcga taa                         43


<210>  48
<211>  53
<212>  DNA
<213>  Escherichia coli

<400>  48
taaagttatc gccactgatc tgcgcccgga agcgttgcag gagttaaaag acg              53


<210>  49
<211>  53
<212>  DNA
<213>  Escherichia coli

<400>  49
cgtcttttaa ctcctgcaac gcttccgggc gcagatcagt ggcgataact tta              53


<210>  50
<211>  53
<212>  DNA
<213>  Escherichia coli

<400>  50
agttatcgcc actgatctgc gccaggccgc gttgcaggag ttaaaagacg aac              53


<210>  51
<211>  53
<212>  DNA
<213>  Escherichia coli

<400>  51
gttcgtcttt taactcctgc aacgcggcct ggcgcagatc agtggcgata act              53


<210>  52
<211>  59
<212>  DNA
<213>  Escherichia coli

<400>  52
gcataaagtt atcgccactg atctgcgcca ggaagcgttg caggagttaa aagacgaac        59


<210>  53
<211>  59
<212>  DNA
<213>  Escherichia coli

<400>  53
gttcgtcttt taactcctgc aacgcttcct ggcgcagatc agtggcgata actttatgc        59


<210>  54
<211>  53
<212>  DNA
<213>  Escherichia coli

<400>  54
gcataaagtt atcgccactg atctgaacca ggaagcgttg caggagttaa aag              53


<210>  55
<211>  53
<212>  DNA
<213>  Escherichia coli

<400>  55
cttttaactc ctgcaacgct tcctggttca gatcagtggc gataacttta tgc              53


<210>  56
<211>  40
<212>  DNA
<213>  Escherichia coli

<400>  56
gtcatcgtag tctagataaa atgatcgttt tggtcaccgg                             40


<210>  57
<211>  28
<212>  DNA
<213>  Escherichia coli

<400>  57
gtgctccatt aattaattat tgtctgtg                                          28


<210>  58
<211>  30
<212>  DNA
<213>  Escherichia coli

<400>  58
gcggaattca tgtttggtaa tatttcccaa                                        30


<210>  59
<211>  29
<212>  DNA
<213>  Escherichia coli

<400>  59
gatcccgggc tatttatcta atgatcctc                                         29


<210>  60
<211>  39
<212>  DNA
<213>  Escherichia coli

<400>  60
gttttagtaa ctggagcagg cgcaggtttt ggtgaatgc                              39


<210>  61
<211>  39
<212>  DNA
<213>  Escherichia coli

<400>  61
gcattcacca aaacctgcgc ctgctccagt tactaaaac                              39


<210>  62
<211>  39
<212>  DNA
<213>  Escherichia coli

<400>  62
cataaagtta tcgccactga tcgtcgccag gaacggttg                              39


<210>  63
<211>  39
<212>  DNA
<213>  Escherichia coli

<400>  63
caaccgttcc tggcgacgat cagtggcgat aactttatg                              39


<210>  64
<211>  40
<212>  DNA
<213>  Escherichia coli

<400>  64
taaagttatc gccactgatc gtcgccagga agcgttgcag                             40


<210>  65
<211>  40
<212>  DNA
<213>  Escherichia coli

<400>  65
ctgcaacgct tcctggcgac gatcagtggc gataacttta                             40


<210>  66
<211>  39
<212>  DNA
<213>  Escherichia coli

<400>  66
actgatctgc gccaggaacg gttgcaggag ttaaaagac                              39


<210>  67
<211>  39
<212>  DNA
<213>  Escherichia coli

<400>  67
gtcttttaac tcctgcaacc gttcctggcg cagatcagt                              39


<210>  68
<211>  39
<212>  DNA
<213>  Escherichia coli

<400>  68
atcctaatta caggtgcggg tactggtatc ggataccat                              39


<210>  69
<211>  39
<212>  DNA
<213>  Escherichia coli

<400>  69
atggtatccg ataccagtac ccgcacctgt aattaggat                              39


<210>  70
<211>  42
<212>  DNA
<213>  Escherichia coli

<400>  70
ttgaagttgg ttttggctga tttaagaaag gagaagctgg ag                          42


<210>  71
<211>  42
<212>  DNA
<213>  Escherichia coli

<400>  71
ctccagcttc tcctttctta aatcagccaa aaccaacttc aa                          42


<210>  72
<211>  31
<212>  DNA
<213>  Escherichia coli

<400>  72
ttgcaggcaa gaacatccta attacaggtg c                                      31


<210>  73
<211>  31
<212>  DNA
<213>  Escherichia coli

<400>  73
gcacctgtaa ttaggatgtt cttgcctgca a                                      31


<210>  74
<211>  33
<212>  DNA
<213>  Escherichia coli

<400>  74
gtagctagct aaaatgtttg gtaatatttc cca                                    33


<210>  75
<211>  31
<212>  DNA
<213>  Escherichia coli

<400>  75
tgcttaatta actatttatc taatgatcct c                                      31


<210>  76
<211>  33
<212>  DNA
<213>  Escherichia coli

<400>  76
ttggtcaccg gtgcaggtgc aggtttcggc gaa                                    33


<210>  77
<211>  33
<212>  DNA
<213>  Escherichia coli

<400>  77
ttcgccgaaa cctgcacctg caccggtgac caa                                    33


<210>  78
<211>  40
<212>  DNA
<213>  Escherichia coli

<400>  78
acaaggttat cgctaccgac ttgagacaag agagattgca                             40


<210>  79
<211>  40
<212>  DNA
<213>  Escherichia coli

<400>  79
tgcaatctct cttgtctcaa gtcggtagcg ataaccttgt                             40


<210>  80
<211>  270
<212>  PRT
<213>  Issatchenkia orientalis

<400>  80

Met Phe Gly Asn Ile Ser Gln Arg Leu Ala Gly Lys Asn Ile Leu Ile 
1               5                   10                  15      


Thr Gly Ala Ser Thr Gly Ile Gly Tyr His Thr Ala Lys Tyr Phe Ala 
            20                  25                  30          


Glu Ala Ala Asn Gly Asp Leu Lys Leu Val Leu Ala Asp Leu Arg Lys 
        35                  40                  45              


Glu Lys Leu Glu Ala Leu Lys Ala Asp Leu Leu Ala Lys Tyr Pro Ser 
    50                  55                  60                  


Ile Lys Val His Ile Glu Ser Leu Asp Val Ser Lys Thr Glu Thr Ile 
65                  70                  75                  80  


Ala Pro Phe Leu Lys Gly Leu Pro Glu Glu Phe Ser Ile Val Asp Val 
                85                  90                  95      


Leu Val Asn Asn Ala Gly Lys Ala Leu Gly Leu Asp Pro Ile Gly Ser 
            100                 105                 110         


Val Asp Pro Lys Asp Val Asp Glu Met Phe Gln Thr Asn Val Leu Gly 
        115                 120                 125             


Met Ile Gln Leu Thr Gln Leu Val Val Gln Gln Met Lys Glu Arg Asn 
    130                 135                 140                 


Ser Gly Asp Ile Val Gln Leu Gly Ser Val Ala Gly Arg Asn Pro Tyr 
145                 150                 155                 160 


Pro Gly Gly Gly Ile Tyr Cys Ala Ser Lys Ala Ala Leu Arg Ser Phe 
                165                 170                 175     


Thr His Val Leu Arg Glu Glu Leu Ile Asn Thr Lys Ile Arg Val Ile 
            180                 185                 190         


Glu Ile Glu Pro Gly Asn Val Ala Thr Glu Glu Phe Ser Leu Thr Arg 
        195                 200                 205             


Phe Lys Gly Asp Lys Ser Lys Ala Glu Lys Val Tyr Glu Gly Thr Glu 
    210                 215                 220                 


Pro Leu Tyr Gly Thr Asp Ile Ala Glu Leu Ile Leu Phe Ala Val Ser 
225                 230                 235                 240 


Arg Pro Gln Asn Thr Val Ile Ala Glu Thr Leu Val Phe Ala Ser Asn 
                245                 250                 255     


Gln Ala Ser Ala Tyr His Ile Phe Arg Gly Ser Leu Asp Lys 
            260                 265                 270 


<210>  81
<211>  270
<212>  PRT
<213>  Issatchenkia orientalis

<400>  81

Met Phe Gly Asn Ile Ser Gln Arg Leu Ala Gly Lys Asn Ile Leu Ile 
1               5                   10                  15      


Thr Gly Ala Gly Thr Gly Ile Gly Tyr His Thr Ala Lys Tyr Phe Ala 
            20                  25                  30          


Glu Ala Ala Asn Gly Asp Leu Lys Leu Val Leu Ala Asp Leu Arg Lys 
        35                  40                  45              


Glu Lys Leu Glu Ala Leu Lys Ala Asp Leu Leu Ala Lys Tyr Pro Ser 
    50                  55                  60                  


Ile Lys Val His Ile Glu Ser Leu Asp Val Ser Lys Thr Glu Thr Ile 
65                  70                  75                  80  


Ala Pro Phe Leu Lys Gly Leu Pro Glu Glu Phe Ser Ile Val Asp Val 
                85                  90                  95      


Leu Val Asn Asn Ala Gly Lys Ala Leu Gly Leu Asp Pro Ile Gly Ser 
            100                 105                 110         


Val Asp Pro Lys Asp Val Asp Glu Met Phe Gln Thr Asn Val Leu Gly 
        115                 120                 125             


Met Ile Gln Leu Thr Gln Leu Val Val Gln Gln Met Lys Glu Arg Asn 
    130                 135                 140                 


Ser Gly Asp Ile Val Gln Leu Gly Ser Val Ala Gly Arg Asn Pro Tyr 
145                 150                 155                 160 


Pro Gly Gly Gly Ile Tyr Cys Ala Ser Lys Ala Ala Leu Arg Ser Phe 
                165                 170                 175     


Thr His Val Leu Arg Glu Glu Leu Ile Asn Thr Lys Ile Arg Val Ile 
            180                 185                 190         


Glu Ile Glu Pro Gly Asn Val Ala Thr Glu Glu Phe Ser Leu Thr Arg 
        195                 200                 205             


Phe Lys Gly Asp Lys Ser Lys Ala Glu Lys Val Tyr Glu Gly Thr Glu 
    210                 215                 220                 


Pro Leu Tyr Gly Thr Asp Ile Ala Glu Leu Ile Leu Phe Ala Val Ser 
225                 230                 235                 240 


Arg Pro Gln Asn Thr Val Ile Ala Glu Thr Leu Val Phe Ala Ser Asn 
                245                 250                 255     


Gln Ala Ser Ala Tyr His Ile Phe Arg Gly Ser Leu Asp Lys 
            260                 265                 270 


<210>  82
<211>  295
<212>  PRT
<213>  Issatchenkia orientalis

<400>  82

Met Arg Ile Ala Phe Ile Gly Leu Gly Asn Met Gly Ala Pro Met Ala 
1               5                   10                  15      


Arg Asn Leu Ile Lys Ala Gly His Gln Leu Asn Leu Phe Asp Leu Asn 
            20                  25                  30          


Lys Ala Val Leu Ala Glu Leu Ala Glu Leu Gly Gly Gln Ile Ser Pro 
        35                  40                  45              


Ser Pro Lys Asp Ala Ala Ala Asn Ser Glu Leu Val Ile Thr Met Leu 
    50                  55                  60                  


Pro Ala Ala Ala His Val Arg Ser Val Tyr Leu Asn Glu Asp Gly Val 
65                  70                  75                  80  


Leu Ala Gly Ile Arg Pro Gly Thr Pro Thr Val Asp Cys Ser Thr Ile 
                85                  90                  95      


Asp Pro Gln Thr Ala Arg Asp Val Ser Lys Ala Ala Ala Ala Lys Gly 
            100                 105                 110         


Val Asp Met Gly Asp Ala Pro Val Ser Gly Gly Thr Gly Gly Ala Ala 
        115                 120                 125             


Ala Gly Thr Leu Thr Phe Met Val Gly Ala Ser Thr Glu Leu Phe Ala 
    130                 135                 140                 


Ser Leu Lys Pro Val Leu Glu Gln Met Gly Arg Asn Ile Val His Cys 
145                 150                 155                 160 


Gly Glu Val Gly Thr Gly Gln Ile Ala Lys Ile Cys Asn Asn Leu Leu 
                165                 170                 175     


Leu Gly Ile Ser Met Ile Gly Val Ser Glu Ala Met Ala Leu Gly Asn 
            180                 185                 190         


Ala Leu Gly Ile Asp Thr Lys Val Leu Ala Gly Ile Ile Asn Ser Ser 
        195                 200                 205             


Thr Gly Arg Cys Trp Ser Ser Asp Thr Tyr Asn Pro Trp Pro Gly Ile 
    210                 215                 220                 


Ile Glu Thr Ala Pro Ala Ser Arg Gly Tyr Thr Gly Gly Phe Gly Ala 
225                 230                 235                 240 


Glu Leu Met Leu Lys Asp Leu Gly Leu Ala Thr Glu Ala Ala Arg Gln 
                245                 250                 255     


Ala His Gln Pro Val Ile Leu Gly Ala Val Ala Gln Gln Leu Tyr Gln 
            260                 265                 270         


Ala Met Ser Leu Arg Gly Glu Gly Gly Lys Asp Phe Ser Ala Ile Val 
        275                 280                 285             


Glu Gly Tyr Arg Lys Lys Asp 
    290                 295 


