                         SEQUENCE LISTING

<110>  ST GEORGE'S HOSPITAL MEDICAL SCHOOL
 
<120>  TREATMENT FOR MITOCHONDRIAL NEUROGASTROINTESTINAL 
       ENCEPHALOMYOPATHY (MNGIE)

<130>  N.114006A

<150>  GB 1116767.3
<151>  2011-09-28

<160>  1     

<170>  PatentIn version 3.5

<210>  1
<211>  440
<212>  PRT
<213>  Escherichia coli

<400>  1

Met Phe Leu Ala Gln Glu Ile Ile Arg Lys Lys Arg Asp Gly His Ala 
1               5                   10                  15      


Leu Ser Asp Glu Glu Ile Arg Phe Phe Ile Asn Gly Ile Arg Asp Asn 
            20                  25                  30          


Thr Ile Ser Glu Gly Gln Ile Ala Ala Leu Ala Met Thr Ile Phe Phe 
        35                  40                  45              


His Asp Met Thr Met Pro Glu Arg Val Ser Leu Thr Met Ala Met Arg 
    50                  55                  60                  


Asp Ser Gly Thr Val Leu Asp Trp Lys Ser Leu His Leu Asn Gly Pro 
65                  70                  75                  80  


Ile Val Asp Lys His Ser Thr Gly Gly Val Gly Asp Val Thr Ser Leu 
                85                  90                  95      


Met Leu Gly Pro Met Val Ala Ala Cys Gly Gly Tyr Ile Pro Met Ile 
            100                 105                 110         


Ser Gly Arg Gly Leu Gly His Thr Gly Gly Thr Leu Asp Lys Leu Glu 
        115                 120                 125             


Ser Ile Pro Gly Phe Asp Ile Phe Pro Asp Asp Asn Arg Phe Arg Glu 
    130                 135                 140                 


Ile Ile Lys Asp Val Gly Val Ala Ile Ile Gly Gln Thr Ser Ser Leu 
145                 150                 155                 160 


Ala Pro Ala Asp Lys Arg Phe Tyr Ala Thr Arg Asp Ile Thr Ala Thr 
                165                 170                 175     


Val Asp Ser Ile Pro Leu Ile Thr Ala Ser Ile Leu Ala Lys Lys Leu 
            180                 185                 190         


Ala Glu Gly Leu Asp Ala Leu Val Met Asp Val Lys Val Gly Ser Gly 
        195                 200                 205             


Ala Phe Met Pro Thr Tyr Glu Leu Ser Glu Ala Leu Ala Glu Ala Ile 
    210                 215                 220                 


Val Gly Val Ala Asn Gly Ala Gly Val Arg Thr Thr Ala Leu Leu Thr 
225                 230                 235                 240 


Asp Met Asn Gln Val Leu Ala Ser Ser Ala Gly Asn Ala Val Glu Val 
                245                 250                 255     


Arg Glu Ala Val Gln Phe Leu Thr Gly Glu Tyr Arg Asn Pro Arg Leu 
            260                 265                 270         


Phe Asp Val Thr Met Ala Leu Cys Val Glu Met Leu Ile Ser Gly Lys 
        275                 280                 285             


Leu Ala Lys Asp Asp Ala Glu Ala Arg Ala Lys Leu Gln Ala Val Leu 
    290                 295                 300                 


Asp Asn Gly Lys Ala Ala Glu Val Phe Gly Arg Met Val Ala Ala Gln 
305                 310                 315                 320 


Lys Gly Pro Thr Asp Phe Val Glu Asn Tyr Ala Lys Tyr Leu Pro Thr 
                325                 330                 335     


Ala Met Leu Thr Lys Ala Val Tyr Ala Asp Thr Glu Gly Phe Val Ser 
            340                 345                 350         


Glu Met Asp Thr Arg Ala Leu Gly Met Ala Val Val Ala Met Gly Gly 
        355                 360                 365             


Gly Arg Arg Gln Ala Ser Asp Thr Ile Asp Tyr Ser Val Gly Phe Thr 
    370                 375                 380                 


Asp Met Ala Arg Leu Gly Asp Gln Val Asp Gly Gln Arg Pro Leu Ala 
385                 390                 395                 400 


Val Ile His Ala Lys Asp Glu Asn Asn Trp Gln Glu Ala Ala Lys Ala 
                405                 410                 415     


Val Lys Ala Ala Ile Lys Leu Ala Asp Lys Ala Pro Glu Ser Thr Pro 
            420                 425                 430         


Thr Val Tyr Arg Arg Ile Ser Glu 
        435                 440 


