                         SEQUENCE LISTING

<110>  Institut National de la Sant et de la Recherche Mdicale 
       (INSERM)
       Ecole Normale Suprieure de Lyon
 
<120>  Lentiviral vectors pseudotyped with mutant BaEV glycoproteins

<130>  BET12P2372

<150>  EP 11306247.5
<151>  2011-09-29

<160>  15    

<170>  PatentIn version 3.4

<210>  1
<211>  1692
<212>  DNA
<213>  Baboon endogenous virus

<400>  1
atgggattca caacaaagat aatcttctta tacaacctag tactggtcta cgcggggttt     60

gacgaccctc gcaaagccat agaactagta caaaagcgat atggccgacc atgcgattgc    120

agcggaggac aagtgtccga gcccccgtca gacagggtca gtcaagtgac ttgctcaggc    180

aagacagctt acttaatgcc cgaccaaaga tggaaatgta agtcaattcc aaaagacacc    240

tccccaagcg ggccactcca agagtgcccc tgtaattctt accagtcctc agtacacagt    300

tcttgttata cctcatacca acaatgcaga tcaggcaata agacatatta tacggctact    360

ctgctaaaaa cacaaactgg gggcaccagt gatgtacaag tattaggatc caccaacaaa    420

cttatacaat ctccctgtaa tggcataaaa gggcagtcta tttgctggag cactacagct    480

cctatccacg tctctgatgg aggaggtcca ttagacacca caagaattaa aagtgttcag    540

agaaaactgg aagaaattca taaagcccta tatcctgaac ttcagtatca ccctttggcc    600

atacctaagg ttagagataa cctcatggtc gatgcccaga ctttaaacat tctcaatgcc    660

acttacaact tactcctaat gtccaacacg agcctagtgg acgactgttg gctttgttta    720

aaattaggtc cccctactcc cctcgcaata cctaacttcc tattatccta cgtgactcgc    780

tcctcggata atatctcttg tttaataatt cccccccttc tagttcaacc gatgcagttt    840

tccaattcat cttgcctctt ttccccctcc tacaacagta cagaagaaat agatctaggc    900

catgttgcct tcagcaactg tacctccata accaatgtca ccggtcccat atgcgctgta    960

aatggttcgg tctttctctg tggcaataac atggcataca cttatctacc cacgaactgg   1020

acggggcttt gcgtcctagc aactctcctc cccgacattg acatcattcc cggagatgaa   1080

ccggtcccca tccctgctat tgatcatttt atatatagac ctaaacgggc catacagttt   1140

attcctttac tagcagggct agggatcacc gcagccttca caacaggagc tacaggccta   1200

ggtgtctctg tgacccaata tacaaaatta tctaatcagc taatttctga tgtacaaatc   1260

ttatctagca ccatacaaga tctgcaagat caagtagact cattagccga agtggttctc   1320

cagaacagaa gggggctaga tctacttaca gcagaacaag gaggaatctg tttagccctg   1380

caagaaaaat gctgctttta tgttaacaag tcagggattg tgagagacaa aataaaaacc   1440

ttacaagaag aactagaaag acgtagaaaa gatctagctt ccaacccact ttggactggg   1500

cttcaagggc tcctccctta cctcctgccc tttcttggcc ctctacttac cctcctgctc   1560

ttactcacca ttgggccgtg catttttaac cgtctaaccg cttttattaa tgataagtta   1620

aacataatac acgctatggt gctaacccaa cagtatcagg tgctcagaac cgatgaagaa   1680

gctcaagatt ga                                                       1692


<210>  2
<211>  563
<212>  PRT
<213>  Baboon endogenous virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(506)
<223>  extracellular domain

<220>
<221>  MISC_FEATURE
<222>  (507)..(529)
<223>  transmembrane domain

<220>
<221>  MISC_FEATURE
<222>  (530)..(564)
<223>  cytoplasmic tail

<220>
<221>  MISC_FEATURE
<222>  (547)..(564)
<223>  R peptide

<400>  2

Met Gly Phe Thr Thr Lys Ile Ile Phe Leu Tyr Asn Leu Val Leu Val 
1               5                   10                  15      


Tyr Ala Gly Phe Asp Asp Pro Arg Lys Ala Ile Glu Leu Val Gln Lys 
            20                  25                  30          


Arg Tyr Gly Arg Pro Cys Asp Cys Ser Gly Gly Gln Val Ser Glu Pro 
        35                  40                  45              


Pro Ser Asp Arg Val Ser Gln Val Thr Cys Ser Gly Lys Thr Ala Tyr 
    50                  55                  60                  


Leu Met Pro Asp Gln Arg Trp Lys Cys Lys Ser Ile Pro Lys Asp Thr 
65                  70                  75                  80  


Ser Pro Ser Gly Pro Leu Gln Glu Cys Pro Cys Asn Ser Tyr Gln Ser 
                85                  90                  95      


Ser Val His Ser Ser Cys Tyr Thr Ser Tyr Gln Gln Cys Arg Ser Gly 
            100                 105                 110         


Asn Lys Thr Tyr Tyr Thr Ala Thr Leu Leu Lys Thr Gln Thr Gly Gly 
        115                 120                 125             


Thr Ser Asp Val Gln Val Leu Gly Ser Thr Asn Lys Leu Ile Gln Ser 
    130                 135                 140                 


Pro Cys Asn Gly Ile Lys Gly Gln Ser Ile Cys Trp Ser Thr Thr Ala 
145                 150                 155                 160 


Pro Ile His Val Ser Asp Gly Gly Gly Pro Leu Asp Thr Thr Arg Ile 
                165                 170                 175     


Lys Ser Val Gln Arg Lys Leu Glu Glu Ile His Lys Ala Leu Tyr Pro 
            180                 185                 190         


Glu Leu Gln Tyr His Pro Leu Ala Ile Pro Lys Val Arg Asp Asn Leu 
        195                 200                 205             


Met Val Asp Ala Gln Thr Leu Asn Ile Leu Asn Ala Thr Tyr Asn Leu 
    210                 215                 220                 


Leu Leu Met Ser Asn Thr Ser Leu Val Asp Asp Cys Trp Leu Cys Leu 
225                 230                 235                 240 


Lys Leu Gly Pro Pro Thr Pro Leu Ala Ile Pro Asn Phe Leu Leu Ser 
                245                 250                 255     


Tyr Val Thr Arg Ser Ser Asp Asn Ile Ser Cys Leu Ile Ile Pro Pro 
            260                 265                 270         


Leu Leu Val Gln Pro Met Gln Phe Ser Asn Ser Ser Cys Leu Phe Ser 
        275                 280                 285             


Pro Ser Tyr Asn Ser Thr Glu Glu Ile Asp Leu Gly His Val Ala Phe 
    290                 295                 300                 


Ser Asn Cys Thr Ser Ile Thr Asn Val Thr Gly Pro Ile Cys Ala Val 
305                 310                 315                 320 


Asn Gly Ser Val Phe Leu Cys Gly Asn Asn Met Ala Tyr Thr Tyr Leu 
                325                 330                 335     


Pro Thr Asn Trp Thr Gly Leu Cys Val Leu Ala Thr Leu Leu Pro Asp 
            340                 345                 350         


Ile Asp Ile Ile Pro Gly Asp Glu Pro Val Pro Ile Pro Ala Ile Asp 
        355                 360                 365             


His Phe Ile Tyr Arg Pro Lys Arg Ala Ile Gln Phe Ile Pro Leu Leu 
    370                 375                 380                 


Ala Gly Leu Gly Ile Thr Ala Ala Phe Thr Thr Gly Ala Thr Gly Leu 
385                 390                 395                 400 


Gly Val Ser Val Thr Gln Tyr Thr Lys Leu Ser Asn Gln Leu Ile Ser 
                405                 410                 415     


Asp Val Gln Ile Leu Ser Ser Thr Ile Gln Asp Leu Gln Asp Gln Val 
            420                 425                 430         


Asp Ser Leu Ala Glu Val Val Leu Gln Asn Arg Arg Gly Leu Asp Leu 
        435                 440                 445             


Leu Thr Ala Glu Gln Gly Gly Ile Cys Leu Ala Leu Gln Glu Lys Cys 
    450                 455                 460                 


Cys Phe Tyr Val Asn Lys Ser Gly Ile Val Arg Asp Lys Ile Lys Thr 
465                 470                 475                 480 


Leu Gln Glu Glu Leu Glu Arg Arg Arg Lys Asp Leu Ala Ser Asn Pro 
                485                 490                 495     


Leu Trp Thr Gly Leu Gln Gly Leu Leu Pro Tyr Leu Leu Pro Phe Leu 
            500                 505                 510         


Gly Pro Leu Leu Thr Leu Leu Leu Leu Leu Thr Ile Gly Pro Cys Ile 
        515                 520                 525             


Phe Asn Arg Leu Thr Ala Phe Ile Asn Asp Lys Leu Asn Ile Ile His 
    530                 535                 540                 


Ala Met Val Leu Thr Gln Gln Tyr Gln Val Leu Arg Thr Asp Glu Glu 
545                 550                 555                 560 


Ala Gln Asp 
            


<210>  3
<211>  34
<212>  PRT
<213>  Baboon endogenous virus

<400>  3

Asn Arg Leu Thr Ala Phe Ile Asn Asp Lys Leu Asn Ile Ile His Ala 
1               5                   10                  15      


Met Val Leu Thr Gln Gln Tyr Gln Val Leu Arg Thr Asp Glu Glu Ala 
            20                  25                  30          


Gln Asp 
        


<210>  4
<211>  23
<212>  PRT
<213>  Baboon endogenous virus

<400>  4

Tyr Leu Leu Pro Phe Leu Gly Pro Leu Leu Thr Leu Leu Leu Leu Leu 
1               5                   10                  15      


Thr Ile Gly Pro Cys Ile Phe 
            20              


<210>  5
<211>  506
<212>  PRT
<213>  Baboon endogenous virus

<400>  5

Met Gly Phe Thr Thr Lys Ile Ile Phe Leu Tyr Asn Leu Val Leu Val 
1               5                   10                  15      


Tyr Ala Gly Phe Asp Asp Pro Arg Lys Ala Ile Glu Leu Val Gln Lys 
            20                  25                  30          


Arg Tyr Gly Arg Pro Cys Asp Cys Ser Gly Gly Gln Val Ser Glu Pro 
        35                  40                  45              


Pro Ser Asp Arg Val Ser Gln Val Thr Cys Ser Gly Lys Thr Ala Tyr 
    50                  55                  60                  


Leu Met Pro Asp Gln Arg Trp Lys Cys Lys Ser Ile Pro Lys Asp Thr 
65                  70                  75                  80  


Ser Pro Ser Gly Pro Leu Gln Glu Cys Pro Cys Asn Ser Tyr Gln Ser 
                85                  90                  95      


Ser Val His Ser Ser Cys Tyr Thr Ser Tyr Gln Gln Cys Arg Ser Gly 
            100                 105                 110         


Asn Lys Thr Tyr Tyr Thr Ala Thr Leu Leu Lys Thr Gln Thr Gly Gly 
        115                 120                 125             


Thr Ser Asp Val Gln Val Leu Gly Ser Thr Asn Lys Leu Ile Gln Ser 
    130                 135                 140                 


Pro Cys Asn Gly Ile Lys Gly Gln Ser Ile Cys Trp Ser Thr Thr Ala 
145                 150                 155                 160 


Pro Ile His Val Ser Asp Gly Gly Gly Pro Leu Asp Thr Thr Arg Ile 
                165                 170                 175     


Lys Ser Val Gln Arg Lys Leu Glu Glu Ile His Lys Ala Leu Tyr Pro 
            180                 185                 190         


Glu Leu Gln Tyr His Pro Leu Ala Ile Pro Lys Val Arg Asp Asn Leu 
        195                 200                 205             


Met Val Asp Ala Gln Thr Leu Asn Ile Leu Asn Ala Thr Tyr Asn Leu 
    210                 215                 220                 


Leu Leu Met Ser Asn Thr Ser Leu Val Asp Asp Cys Trp Leu Cys Leu 
225                 230                 235                 240 


Lys Leu Gly Pro Pro Thr Pro Leu Ala Ile Pro Asn Phe Leu Leu Ser 
                245                 250                 255     


Tyr Val Thr Arg Ser Ser Asp Asn Ile Ser Cys Leu Ile Ile Pro Pro 
            260                 265                 270         


Leu Leu Val Gln Pro Met Gln Phe Ser Asn Ser Ser Cys Leu Phe Ser 
        275                 280                 285             


Pro Ser Tyr Asn Ser Thr Glu Glu Ile Asp Leu Gly His Val Ala Phe 
    290                 295                 300                 


Ser Asn Cys Thr Ser Ile Thr Asn Val Thr Gly Pro Ile Cys Ala Val 
305                 310                 315                 320 


Asn Gly Ser Val Phe Leu Cys Gly Asn Asn Met Ala Tyr Thr Tyr Leu 
                325                 330                 335     


Pro Thr Asn Trp Thr Gly Leu Cys Val Leu Ala Thr Leu Leu Pro Asp 
            340                 345                 350         


Ile Asp Ile Ile Pro Gly Asp Glu Pro Val Pro Ile Pro Ala Ile Asp 
        355                 360                 365             


His Phe Ile Tyr Arg Pro Lys Arg Ala Ile Gln Phe Ile Pro Leu Leu 
    370                 375                 380                 


Ala Gly Leu Gly Ile Thr Ala Ala Phe Thr Thr Gly Ala Thr Gly Leu 
385                 390                 395                 400 


Gly Val Ser Val Thr Gln Tyr Thr Lys Leu Ser Asn Gln Leu Ile Ser 
                405                 410                 415     


Asp Val Gln Ile Leu Ser Ser Thr Ile Gln Asp Leu Gln Asp Gln Val 
            420                 425                 430         


Asp Ser Leu Ala Glu Val Val Leu Gln Asn Arg Arg Gly Leu Asp Leu 
        435                 440                 445             


Leu Thr Ala Glu Gln Gly Gly Ile Cys Leu Ala Leu Gln Glu Lys Cys 
    450                 455                 460                 


Cys Phe Tyr Val Asn Lys Ser Gly Ile Val Arg Asp Lys Ile Lys Thr 
465                 470                 475                 480 


Leu Gln Glu Glu Leu Glu Arg Arg Arg Lys Asp Leu Ala Ser Asn Pro 
                485                 490                 495     


Leu Trp Thr Gly Leu Gln Gly Leu Leu Pro 
            500                 505     


<210>  6
<211>  17
<212>  PRT
<213>  Baboon endogenous virus

<400>  6

Val Leu Thr Gln Gln Tyr Gln Val Leu Arg Thr Asp Glu Glu Ala Gln 
1               5                   10                  15      


Asp 
    


<210>  7
<211>  546
<212>  PRT
<213>  Artificial

<220>
<223>  BaEVRLess

<400>  7

Met Gly Phe Thr Thr Lys Ile Ile Phe Leu Tyr Asn Leu Val Leu Val 
1               5                   10                  15      


Tyr Ala Gly Phe Asp Asp Pro Arg Lys Ala Ile Glu Leu Val Gln Lys 
            20                  25                  30          


Arg Tyr Gly Arg Pro Cys Asp Cys Ser Gly Gly Gln Val Ser Glu Pro 
        35                  40                  45              


Pro Ser Asp Arg Val Ser Gln Val Thr Cys Ser Gly Lys Thr Ala Tyr 
    50                  55                  60                  


Leu Met Pro Asp Gln Arg Trp Lys Cys Lys Ser Ile Pro Lys Asp Thr 
65                  70                  75                  80  


Ser Pro Ser Gly Pro Leu Gln Glu Cys Pro Cys Asn Ser Tyr Gln Ser 
                85                  90                  95      


Ser Val His Ser Ser Cys Tyr Thr Ser Tyr Gln Gln Cys Arg Ser Gly 
            100                 105                 110         


Asn Lys Thr Tyr Tyr Thr Ala Thr Leu Leu Lys Thr Gln Thr Gly Gly 
        115                 120                 125             


Thr Ser Asp Val Gln Val Leu Gly Ser Thr Asn Lys Leu Ile Gln Ser 
    130                 135                 140                 


Pro Cys Asn Gly Ile Lys Gly Gln Ser Ile Cys Trp Ser Thr Thr Ala 
145                 150                 155                 160 


Pro Ile His Val Ser Asp Gly Gly Gly Pro Leu Asp Thr Thr Arg Ile 
                165                 170                 175     


Lys Ser Val Gln Arg Lys Leu Glu Glu Ile His Lys Ala Leu Tyr Pro 
            180                 185                 190         


Glu Leu Gln Tyr His Pro Leu Ala Ile Pro Lys Val Arg Asp Asn Leu 
        195                 200                 205             


Met Val Asp Ala Gln Thr Leu Asn Ile Leu Asn Ala Thr Tyr Asn Leu 
    210                 215                 220                 


Leu Leu Met Ser Asn Thr Ser Leu Val Asp Asp Cys Trp Leu Cys Leu 
225                 230                 235                 240 


Lys Leu Gly Pro Pro Thr Pro Leu Ala Ile Pro Asn Phe Leu Leu Ser 
                245                 250                 255     


Tyr Val Thr Arg Ser Ser Asp Asn Ile Ser Cys Leu Ile Ile Pro Pro 
            260                 265                 270         


Leu Leu Val Gln Pro Met Gln Phe Ser Asn Ser Ser Cys Leu Phe Ser 
        275                 280                 285             


Pro Ser Tyr Asn Ser Thr Glu Glu Ile Asp Leu Gly His Val Ala Phe 
    290                 295                 300                 


Ser Asn Cys Thr Ser Ile Thr Asn Val Thr Gly Pro Ile Cys Ala Val 
305                 310                 315                 320 


Asn Gly Ser Val Phe Leu Cys Gly Asn Asn Met Ala Tyr Thr Tyr Leu 
                325                 330                 335     


Pro Thr Asn Trp Thr Gly Leu Cys Val Leu Ala Thr Leu Leu Pro Asp 
            340                 345                 350         


Ile Asp Ile Ile Pro Gly Asp Glu Pro Val Pro Ile Pro Ala Ile Asp 
        355                 360                 365             


His Phe Ile Tyr Arg Pro Lys Arg Ala Ile Gln Phe Ile Pro Leu Leu 
    370                 375                 380                 


Ala Gly Leu Gly Ile Thr Ala Ala Phe Thr Thr Gly Ala Thr Gly Leu 
385                 390                 395                 400 


Gly Val Ser Val Thr Gln Tyr Thr Lys Leu Ser Asn Gln Leu Ile Ser 
                405                 410                 415     


Asp Val Gln Ile Leu Ser Ser Thr Ile Gln Asp Leu Gln Asp Gln Val 
            420                 425                 430         


Asp Ser Leu Ala Glu Val Val Leu Gln Asn Arg Arg Gly Leu Asp Leu 
        435                 440                 445             


Leu Thr Ala Glu Gln Gly Gly Ile Cys Leu Ala Leu Gln Glu Lys Cys 
    450                 455                 460                 


Cys Phe Tyr Val Asn Lys Ser Gly Ile Val Arg Asp Lys Ile Lys Thr 
465                 470                 475                 480 


Leu Gln Glu Glu Leu Glu Arg Arg Arg Lys Asp Leu Ala Ser Asn Pro 
                485                 490                 495     


Leu Trp Thr Gly Leu Gln Gly Leu Leu Pro Tyr Leu Leu Pro Phe Leu 
            500                 505                 510         


Gly Pro Leu Leu Thr Leu Leu Leu Leu Leu Thr Ile Gly Pro Cys Ile 
        515                 520                 525             


Phe Asn Arg Leu Thr Ala Phe Ile Asn Asp Lys Leu Asn Ile Ile His 
    530                 535                 540                 


Ala Met 
545     


<210>  8
<211>  33
<212>  PRT
<213>  Murine leukemia virus

<400>  8

Asn Arg Leu Val Gln Phe Val Lys Asp Arg Ile Ser Val Val Gln Ala 
1               5                   10                  15      


Leu Val Leu Thr Gln Gln Tyr His Gln Leu Lys Pro Leu Glu Tyr Glu 
            20                  25                  30          


Pro 
    


<210>  9
<211>  562
<212>  PRT
<213>  Artificial

<220>
<223>  BaEV/TR

<400>  9

Met Gly Phe Thr Thr Lys Ile Ile Phe Leu Tyr Asn Leu Val Leu Val 
1               5                   10                  15      


Tyr Ala Gly Phe Asp Asp Pro Arg Lys Ala Ile Glu Leu Val Gln Lys 
            20                  25                  30          


Arg Tyr Gly Arg Pro Cys Asp Cys Ser Gly Gly Gln Val Ser Glu Pro 
        35                  40                  45              


Pro Ser Asp Arg Val Ser Gln Val Thr Cys Ser Gly Lys Thr Ala Tyr 
    50                  55                  60                  


Leu Met Pro Asp Gln Arg Trp Lys Cys Lys Ser Ile Pro Lys Asp Thr 
65                  70                  75                  80  


Ser Pro Ser Gly Pro Leu Gln Glu Cys Pro Cys Asn Ser Tyr Gln Ser 
                85                  90                  95      


Ser Val His Ser Ser Cys Tyr Thr Ser Tyr Gln Gln Cys Arg Ser Gly 
            100                 105                 110         


Asn Lys Thr Tyr Tyr Thr Ala Thr Leu Leu Lys Thr Gln Thr Gly Gly 
        115                 120                 125             


Thr Ser Asp Val Gln Val Leu Gly Ser Thr Asn Lys Leu Ile Gln Ser 
    130                 135                 140                 


Pro Cys Asn Gly Ile Lys Gly Gln Ser Ile Cys Trp Ser Thr Thr Ala 
145                 150                 155                 160 


Pro Ile His Val Ser Asp Gly Gly Gly Pro Leu Asp Thr Thr Arg Ile 
                165                 170                 175     


Lys Ser Val Gln Arg Lys Leu Glu Glu Ile His Lys Ala Leu Tyr Pro 
            180                 185                 190         


Glu Leu Gln Tyr His Pro Leu Ala Ile Pro Lys Val Arg Asp Asn Leu 
        195                 200                 205             


Met Val Asp Ala Gln Thr Leu Asn Ile Leu Asn Ala Thr Tyr Asn Leu 
    210                 215                 220                 


Leu Leu Met Ser Asn Thr Ser Leu Val Asp Asp Cys Trp Leu Cys Leu 
225                 230                 235                 240 


Lys Leu Gly Pro Pro Thr Pro Leu Ala Ile Pro Asn Phe Leu Leu Ser 
                245                 250                 255     


Tyr Val Thr Arg Ser Ser Asp Asn Ile Ser Cys Leu Ile Ile Pro Pro 
            260                 265                 270         


Leu Leu Val Gln Pro Met Gln Phe Ser Asn Ser Ser Cys Leu Phe Ser 
        275                 280                 285             


Pro Ser Tyr Asn Ser Thr Glu Glu Ile Asp Leu Gly His Val Ala Phe 
    290                 295                 300                 


Ser Asn Cys Thr Ser Ile Thr Asn Val Thr Gly Pro Ile Cys Ala Val 
305                 310                 315                 320 


Asn Gly Ser Val Phe Leu Cys Gly Asn Asn Met Ala Tyr Thr Tyr Leu 
                325                 330                 335     


Pro Thr Asn Trp Thr Gly Leu Cys Val Leu Ala Thr Leu Leu Pro Asp 
            340                 345                 350         


Ile Asp Ile Ile Pro Gly Asp Glu Pro Val Pro Ile Pro Ala Ile Asp 
        355                 360                 365             


His Phe Ile Tyr Arg Pro Lys Arg Ala Ile Gln Phe Ile Pro Leu Leu 
    370                 375                 380                 


Ala Gly Leu Gly Ile Thr Ala Ala Phe Thr Thr Gly Ala Thr Gly Leu 
385                 390                 395                 400 


Gly Val Ser Val Thr Gln Tyr Thr Lys Leu Ser Asn Gln Leu Ile Ser 
                405                 410                 415     


Asp Val Gln Ile Leu Ser Ser Thr Ile Gln Asp Leu Gln Asp Gln Val 
            420                 425                 430         


Asp Ser Leu Ala Glu Val Val Leu Gln Asn Arg Arg Gly Leu Asp Leu 
        435                 440                 445             


Leu Thr Ala Glu Gln Gly Gly Ile Cys Leu Ala Leu Gln Glu Lys Cys 
    450                 455                 460                 


Cys Phe Tyr Val Asn Lys Ser Gly Ile Val Arg Asp Lys Ile Lys Thr 
465                 470                 475                 480 


Leu Gln Glu Glu Leu Glu Arg Arg Arg Lys Asp Leu Ala Ser Asn Pro 
                485                 490                 495     


Leu Trp Thr Gly Leu Gln Gly Leu Leu Pro Tyr Leu Leu Pro Phe Leu 
            500                 505                 510         


Gly Pro Leu Leu Thr Leu Leu Leu Leu Leu Thr Ile Gly Pro Cys Ile 
        515                 520                 525             


Phe Asn Arg Leu Val Gln Phe Val Lys Asp Arg Ile Ser Val Val Gln 
    530                 535                 540                 


Ala Leu Val Leu Thr Gln Gln Tyr His Gln Leu Lys Pro Leu Glu Tyr 
545                 550                 555                 560 


Glu Pro 
        


<210>  10
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Lys Lys Thr Gln Thr Trp Ile Leu Thr Cys Ile Tyr Leu Gln Leu 
1               5                   10                  15      


Leu Leu Phe Asn Pro Leu Val Lys Thr Glu Gly Ile Cys Arg Asn Arg 
            20                  25                  30          


Val Thr Asn Asn Val Lys Asp Val Thr Lys Leu Val Ala Asn Leu Pro 
        35                  40                  45              


Lys Asp Tyr Met Ile Thr Leu Lys Tyr Val Pro Gly Met Asp Val Leu 
    50                  55                  60                  


Pro Ser His Cys Trp Ile Ser Glu Met Val Val Gln Leu Ser Asp Ser 
65                  70                  75                  80  


Leu Thr Asp Leu Leu Asp Lys Phe Ser Asn Ile Ser Glu Gly Leu Ser 
                85                  90                  95      


Asn Tyr Ser Ile Ile Asp Lys Leu Val Asn Ile Val Asp Asp Leu Val 
            100                 105                 110         


Glu Cys Val Lys Glu Asn Ser Ser Lys Asp Leu Lys Lys Ser Phe Lys 
        115                 120                 125             


Ser Pro Glu Pro Arg Leu Phe Thr Pro Glu Glu Phe Phe Arg Ile Phe 
    130                 135                 140                 


Asn Arg Ser Ile Asp Ala Phe Lys Asp Phe Val Val Ala Ser Glu Thr 
145                 150                 155                 160 


Ser Asp Cys Val Val Ser Ser Thr Leu Ser Pro Glu Lys Asp Ser Arg 
                165                 170                 175     


Val Ser Val Thr Lys Pro Phe Met Leu Pro Pro Val Ala Ala Ser Ser 
            180                 185                 190         


Leu Arg Asn Asp Ser Ser Ser Ser Asn Arg Lys Ala Lys Asn Pro Pro 
        195                 200                 205             


Gly Asp Ser Ser Leu His Trp Ala Ala Met Ala Leu Pro Ala Leu Phe 
    210                 215                 220                 


Ser Leu Ile Ile Gly Phe Ala Phe Gly Ala Leu Tyr Trp Lys Lys Arg 
225                 230                 235                 240 


Gln Pro Ser Leu Thr Arg Ala Val Glu Asn Ile Gln Ile Asn Glu Glu 
                245                 250                 255     


Asp Asn Glu Ile Ser Met Leu Gln Glu Lys Glu Arg Glu Phe Gln Glu 
            260                 265                 270         


Val 
    


<210>  11
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Glu Leu Thr Glu Leu Leu Leu Val Val Met Leu Leu Leu Thr Ala 
1               5                   10                  15      


Arg Leu Thr Leu Ser Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val 
            20                  25                  30          


Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser 
        35                  40                  45              


Gln Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala 
    50                  55                  60                  


Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys 
65                  70                  75                  80  


Ala Gln Asp Ile Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met 
                85                  90                  95      


Ala Ala Arg Gly Gln Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly 
            100                 105                 110         


Gln Leu Ser Gly Gln Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu 
        115                 120                 125             


Leu Gly Thr Gln Leu Pro Pro Gln Gly Arg Thr Thr Ala His Lys Asp 
    130                 135                 140                 


Pro Asn Ala Ile Phe Leu Ser Phe Gln His Leu Leu Arg Gly Lys Val 
145                 150                 155                 160 


Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Arg Ala 
                165                 170                 175     


Pro Pro Thr Thr Ala Val Pro Ser Arg Thr Ser Leu Val Leu Thr Leu 
            180                 185                 190         


Asn Glu Leu Pro Asn Arg Thr Ser Gly Leu Leu Glu Thr Asn Phe Thr 
        195                 200                 205             


Ala Ser Ala Arg Thr Thr Gly Ser Gly Leu Leu Lys Trp Gln Gln Gly 
    210                 215                 220                 


Phe Arg Ala Lys Ile Pro Gly Leu Leu Asn Gln Thr Ser Arg Ser Leu 
225                 230                 235                 240 


Asp Gln Ile Pro Gly Tyr Leu Asn Arg Ile His Glu Leu Leu Asn Gly 
                245                 250                 255     


Thr Arg Gly Leu Phe Pro Gly Pro Ser Arg Arg Thr Leu Gly Ala Pro 
            260                 265                 270         


Asp Ile Ser Ser Gly Thr Ser Asp Thr Gly Ser Leu Pro Pro Asn Leu 
        275                 280                 285             


Gln Pro Gly Tyr Ser Pro Ser Pro Thr His Pro Pro Thr Gly Gln Tyr 
    290                 295                 300                 


Thr Leu Phe Pro Leu Pro Pro Thr Leu Pro Thr Pro Val Val Gln Leu 
305                 310                 315                 320 


His Pro Leu Leu Pro Asp Pro Ser Ala Pro Thr Pro Thr Pro Thr Ser 
                325                 330                 335     


Pro Leu Leu Asn Thr Ser Tyr Thr His Ser Gln Asn Leu Ser Gln Glu 
            340                 345                 350         


Gly 
    


<210>  12
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  13
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His 
    


<210>  14
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys 
            20                  25                  30          


Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr 
        35                  40                  45              


Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys 
    50                  55                  60                  


Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser 
65                  70                  75                  80  


Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu 
                85                  90                  95      


Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu 
            100                 105                 110         


Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile 
        115                 120                 125             


Val Gln Met Phe Ile Asn Thr Ser 
    130                 135     


<210>  15
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ser Gly Leu Ser Gly Thr Gln Asp Cys Ser Phe 
            20                  25                  30          


Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 
        35                  40                  45              


Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 
    50                  55                  60                  


Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 
65                  70                  75                  80  


Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 
                85                  90                  95      


Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 
            100                 105                 110         


Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        115                 120                 125             


Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 
    130                 135                 140                 


Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala 
                165                 170                 175     


Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu Leu Leu Leu Leu Leu Leu 
            180                 185                 190         


Pro Val Gly Leu Leu Leu Leu Ala Ala Ala Trp Cys Leu His Trp Gln 
        195                 200                 205             


Arg Thr Arg Arg Arg Thr Pro Arg Pro Gly Glu Gln Val Pro Pro Val 
    210                 215                 220                 


Pro Ser Pro Gln Asp Leu Leu Leu Val Glu His 
225                 230                 235 


