                         SEQUENCE LISTING

<110>  Universitaet Zuerich
 
<120>  APC-mediated tolerance induction for therapy of multiple sclerosis

<130>  uz126wo

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  748
<212>  DNA
<213>  Homo sapiens

<400>  1
atggcctgtt tgtggagctt ctcttggccc agctgcttcc tctcccttct cctcctcctt       60

ctcctccagt tgtcatgcag ctatgcagga caattcagag tgataggacc agggtatccc      120

atccgggctt tagttgggga tgaagcagag ctgccgtgcc gcatctctcc tgggaaaaat      180

gccacgggca tggaggtggg ttggtaccgt tctcccttct caagagtggt tcacctctac      240

cgaaatggca aggaccaaga tgcagagcaa gcacctgaat accggggacg cacagagctt      300

ctgaaagaga ctatcagtga gggaaaggtt acccttagga ttcagaacgt gagattctca      360

gatgaaggag gctacacctg cttcttcaga gaccactctt accaagaaga ggcagcaatg      420

gagttgaaag tggaagatcc cttctattgg gtcaaccccg gtgtgctgac tctcatcgca      480

cttgtgccta cgatcctcct gcaggtctct gtaggccttg tattcctctt cctgcagcac      540

agactgagag gaaaacttcg tgcagaagta gagaatctcc atcggacttt tgatcctcac      600

ttcctgaggg tgccctgctg gaagataaca ctgtttgtta ttgtgcctgt tcttggaccc      660

ctggttgcct tgatcatctg ctacaactgg ctgcaccgaa gactggcagg acagtttctt      720

gaagagctaa gaaacccctt ttgagtga                                         748


<210>  2
<211>  1756
<212>  DNA
<213>  Homo sapiens

<400>  2
gcatcgttct gtgttgtctc tgtctgacgt ggttctgtat tgtctgaaaa tagcggcctg       60

cctctaagga agaaataatt ctgcatagaa atcacttgtg accttgggct ccaaagtcaa      120

ctctttcctg gacccataat ctatcatttc tgtctcatag cttcaacttg ccctcaacag      180

attaaattgc atttaactga atcaaaatga ataaaactcc caaaatttca atgaagaaaa      240

aaattgtgga tgcagatttt ggaattacaa atctacaact gaatgaacca attcattaaa      300

cctgccctgc cttcaaaata tgtgtatgca tgtatatata aatagataca tatatgagtg      360

tatatatata tatgtgcgtg tgtgtgtgtg tgtgtgtgtg tagacatata tatttgtttc      420

tcttataaat tacaagtctt ttaaaatcag aatttggaat tttatttggt ttttacatct      480

ctcagtgtct aagcatttta aagaatttca acaaatacct gttgatctat cagttatttc      540

caaatgaata cttccaaaat tttagggaga caggaaaact gttggcattg ttgaagagtc      600

cagacagcac atatgaaata aataaaagaa acattttgag aagagagaat atcgataatt      660

taatcaggag attaattgta aatgtcactt cttaatgtgt aggtgtgtct ttgaaattct      720

gacaagcttg caaatgcata tgggtaataa ttttgaaaat atgacttgat accttgacat      780

ttctatagct tctcactcag tcatatgatc aaaattgtta ttagtaataa tatttaaggc      840

aacatccttc ttagagacat ttgaatttgc ctagaaattg taaatttttt tgcttttaaa      900

tttttttctt attagatatt ttcttcattt acatttcaaa tgctatcccc aaagtcccct      960

ataccctctc ccagacctgc tctccaaccc acccactccc gcttcctggc cctggcgttc     1020

ccctgtacta gagcgtatga tcttcgcgag accaagggcc tctcctccca atgatggccg     1080

actaagccat ttaacataaa aactttcaca gactgattga ctggctttat acaaagtttt     1140

tgagacttgt ctacatcttt tgaagaacaa tggtcttttc agccagagaa gtaaacttct     1200

aagctgataa gtactatgtg tgcgttggaa tcacctagta gcttcagagc tatgggctca     1260

tccagaaatc tgacttttca gctgtgggtg gggcctgagg gcaagaccaa tctgccctcc     1320

ccatggctgg ggtgagcagg gaggaaaaag ggaaggaaga gaatgggggg gggtcctcat     1380

ttctacaact cattgttttg aaaatatcct attatgttat ttcctagggt taatgtctaa     1440

ggaaagtgct ggaatgaaac ctgtggctcc tttttccagt ttttaccctt gatgacatta     1500

aataacttcg tcactttgtg gaggaaatga gaagattgat tcagggtgat gtggcccacc     1560

taccttctca tgtccagttc ccctttccct gacctatatt aagcctacga gcttccagaa     1620

gggtgtgctt tgtgcttgtg gaggaaccta agcggaactt gtaagtaaac tttcaaatat     1680

aatcttgctt ctaaaattgc ttttaaaaga atccaggaat ccaggaatcc aggaatccag     1740

ccccaggacc agagag                                                     1756


<210>  3
<211>  34
<212>  DNA
<213>  Homo sapiens

<400>  3
gtaccggtgc caccatggcc tgtttgtgga gctt                                   34


<210>  4
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  4
aggaattccc aggaagacac aaccatcac                                         29


<210>  5
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gly Asn His Ala Gly Lys Arg Glu Leu Asn Ala Glu Lys Ala Ser 
1               5                   10                  15      


Thr Asn Ser Glu Thr Asn Arg Gly Glu Ser Glu Lys Lys Arg Asn Leu 
            20                  25                  30          


Gly Glu Leu Ser Arg Thr Thr Ser Glu Asp Asn Glu Val Phe Gly Glu 
        35                  40                  45              


Ala Asp Ala Asn Gln Asn Asn Gly Thr Ser Ser Gln Asp Thr Ala Val 
    50                  55                  60                  


Thr Asp Ser Lys Arg Thr Ala Asp Pro Lys Asn Ala Trp Gln Asp Ala 
65                  70                  75                  80  


His Pro Ala Asp Pro Gly Ser Arg Pro His Leu Ile Arg Leu Phe Ser 
                85                  90                  95      


Arg Asp Ala Pro Gly Arg Glu Asp Asn Thr Phe Lys Asp Arg Pro Ser 
            100                 105                 110         


Glu Ser Asp Glu Leu Gln Thr Ile Gln Glu Asp Ser Ala Ala Thr Ser 
        115                 120                 125             


Glu Ser Leu Asp Val Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His 
    130                 135                 140                 


Gly Ser Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His 
145                 150                 155                 160 


Gly Phe Leu Pro Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly 
                165                 170                 175     


Arg Phe Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys 
            180                 185                 190         


Asp Ser His His Pro Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln 
        195                 200                 205             


Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro Val Val His Phe Phe 
    210                 215                 220                 


Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly 
225                 230                 235                 240 


Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg 
                245                 250                 255     


Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His 
            260                 265                 270         


Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe 
        275                 280                 285             


Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser Pro 
    290                 295                 300 


<210>  6
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 
1               5                   10                  15      


Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 
            20                  25                  30          


His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 
        35                  40                  45              


Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Val Pro Trp Leu Lys 
    50                  55                  60                  


Pro Gly Arg Ser Pro Leu Pro Ser His Ala Arg Ser Gln Pro Gly Leu 
65                  70                  75                  80  


Cys Asn Met Tyr Lys Asp Ser His His Pro Ala Arg Thr Ala His Tyr 
                85                  90                  95      


Gly Ser Leu Pro Gln Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro 
            100                 105                 110         


Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro 
        115                 120                 125             


Ser Gln Gly Lys Gly Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr Gly 
    130                 135                 140                 


Gly Arg Ala Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val 
145                 150                 155                 160 


Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp 
                165                 170                 175     


Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 
            180                 185     


<210>  7
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gly Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe 
1               5                   10                  15      


Ala Ser Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe 
            20                  25                  30          


Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu 
        35                  40                  45              


Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val 
    50                  55                  60                  


Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe 
65                  70                  75                  80  


Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala 
                85                  90                  95      


Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly 
            100                 105                 110         


Leu Ser Ala Thr Val Thr Gly Gly Gln Lys Gly Arg Gly Ser Arg Gly 
        115                 120                 125             


Gln His Gln Ala His Ser Leu Glu Arg Val Cys His Cys Leu Gly Lys 
    130                 135                 140                 


Trp Leu Gly His Pro Asp Lys Phe Val Gly Ile Thr Tyr Ala Leu Thr 
145                 150                 155                 160 


Val Val Trp Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile 
                165                 170                 175     


Tyr Phe Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys 
            180                 185                 190         


Thr Ser Ala Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly 
        195                 200                 205             


Val Leu Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu 
    210                 215                 220                 


Leu Ser Ile Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe 
225                 230                 235                 240 


Ile Ala Ala Phe Val Gly Ala Ala Ala Thr Leu Val Ser Leu Leu Thr 
                245                 250                 255     


Phe Met Ile Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly 
            260                 265                 270         


Arg Gly Thr Lys Phe 
        275         


<210>  8
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gly Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe 
1               5                   10                  15      


Ala Ser Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe 
            20                  25                  30          


Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu 
        35                  40                  45              


Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val 
    50                  55                  60                  


Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe 
65                  70                  75                  80  


Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala 
                85                  90                  95      


Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly 
            100                 105                 110         


Leu Ser Ala Thr Phe Val Gly Ile Thr Tyr Ala Leu Thr Val Val Trp 
        115                 120                 125             


Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile Tyr Phe Asn 
    130                 135                 140                 


Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala 
145                 150                 155                 160 


Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly Val Leu Pro 
                165                 170                 175     


Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu Leu Ser Ile 
            180                 185                 190         


Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe Ile Ala Ala 
        195                 200                 205             


Phe Val Gly Ala Ala Ala Thr Leu Val Ser Leu Leu Thr Phe Met Ile 
    210                 215                 220                 


Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly Arg Gly Thr 
225                 230                 235                 240 


Lys Phe 
        


<210>  9
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys 
        195                 200                 205             


Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu 
    210                 215                 220                 


Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu 
225                 230                 235                 240 


Glu Glu Leu Arg Asn Pro Phe 
                245         


<210>  10
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Gly Gln Phe Leu Glu Glu Leu Arg Asn Pro Phe 
        195                 200                 205             


<210>  11
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Glu Ser Phe Gly Val Leu Gly Pro Gln Val Lys 
        195                 200                 205             


Glu Pro Lys Lys Thr Gly Gln Phe Leu Glu Glu Leu Arg Asn Pro Phe 
    210                 215                 220                 


<210>  12
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Asp Pro Phe 
            20                  25                  30          


Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala Val Leu Pro Val 
        35                  40                  45              


Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu Cys Leu Gln Tyr 
    50                  55                  60                  


Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn Leu His Arg Thr 
65                  70                  75                  80  


Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys Ile Thr Leu Phe 
                85                  90                  95      


Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu Ile Ile Cys Tyr 
            100                 105                 110         


Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu Glu Glu Leu Arg 
        115                 120                 125             


Asn Pro Phe 
    130     


<210>  13
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Asp Pro Phe 
            20                  25                  30          


Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala Val Leu Pro Val 
        35                  40                  45              


Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu Cys Leu Gln Tyr 
    50                  55                  60                  


Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn Leu His Arg Thr 
65                  70                  75                  80  


Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys Ile Thr Leu Phe 
                85                  90                  95      


Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu Ile Ile Cys Tyr 
            100                 105                 110         


Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu Glu Glu Leu Arg 
        115                 120                 125             


Asn Pro Phe 
    130     


<210>  14
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Gly Gln Phe Leu Glu Glu Leu Leu Phe His Leu 
        195                 200                 205             


Glu Ala Leu Ser Gly 
    210             


<210>  15
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Glu Ser Phe Gly Val Leu Gly Pro Gln Val Lys 
        195                 200                 205             


Glu Pro Lys Lys Thr Gly Gln Phe Leu Glu Glu Leu Leu Phe His Leu 
    210                 215                 220                 


Glu Ala Leu Ser Gly 
225                 


<210>  16
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Leu Phe His Leu Glu Ala Leu Ser Gly 
        195                 200                 205     


<210>  17
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Gly Lys Phe Arg His Val 
        195                 200             


<210>  18
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Val Ser His Ser Val Thr Gln Asp Trp Leu Gln Trp His Asp His 
145                 150                 155                 160 


Gly Ser Leu Gln Pro Pro Pro Pro Arg Leu Lys 
                165                 170     


<210>  19
<211>  51
<212>  DNA
<213>  Homo sapiens

<400>  19
tggcatttct gcattcgaag aagaatctga gagaaacctg acgcagggag c                51


<210>  20
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 
1               5                   10                  15      


Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 
            20                  25                  30          


His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 
        35                  40                  45              


Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Val Pro Trp Leu Lys 
    50                  55                  60                  


Pro Gly Arg Ser Pro Leu Pro Ser His Ala Arg Ser Gln Pro Gly Leu 
65                  70                  75                  80  


Cys Asn Met Tyr Lys Asp Ser His His Pro Ala Arg Thr Ala His Tyr 
                85                  90                  95      


Gly Ser Leu Pro Gln Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro 
            100                 105                 110         


Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro 
        115                 120                 125             


Ser Gln Gly Lys Gly Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly 
    130                 135                 140                 


Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp 
145                 150                 155                 160 


Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr 
                165                 170                 175     


Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser 
            180                 185                 190         


Pro Met Ala Arg Arg 
        195         


<210>  21
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  21

Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg 
1               5                   10                  15  


<210>  22
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  22

Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln Lys Ser His Gly 
1               5                   10                  15  


<210>  23
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  23

Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg 
1               5                   10                  15      


Thr Pro Pro 
            


<210>  24
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  24

Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg Pro Gly Phe Gly 
1               5                   10                  15      


Tyr Gly Gly 
            


<210>  25
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  25

His Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser 
1               5                   10                  


<210>  26
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  26

Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu 
1               5                   10                  15      


Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val 
            20                  25                  30          


Ile His Ala Phe Gln Tyr Val Ile 
        35                  40  


<210>  27
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  27

Gly Thr Glu Lys Leu Ile Glu Thr Tyr Phe Ser Lys Asn Tyr Gln Asp 
1               5                   10                  15      


Tyr Glu Tyr Leu Ile 
            20      


<210>  28
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  28

Tyr Thr Thr Gly Ala Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr 
1               5                   10                  15      


Ile Cys Gly Lys Gly Leu Ser Ala Thr Val Thr Gly Gly Gln 
            20                  25                  30  


<210>  29
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  29

Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser 
1               5                   10                  15      


Ala Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly Val Leu 
            20                  25                  30          


Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu Leu Ser 
        35                  40                  45              


Ile Cys Lys 
    50      


<210>  30
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  30

Phe Phe Arg Asp His Ser Tyr Gln Glu 
1               5                   


<210>  31
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  31

Leu Val Gly Asp Glu Val Glu Leu Pro 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  32

Leu Arg Ile Arg Asn Val Arg Phe Ser 
1               5                   


<210>  33
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  33

Tyr Trp Val Ser Pro Gly Val Leu Val 
1               5                   


<210>  34
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  34

Tyr Arg Pro Pro Phe Ser Arg Val Val 
1               5                   


<210>  35
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Gly Asn His Ala Gly Lys Arg Glu Leu Asn Ala Glu Lys Ala Ser 
1               5                   10                  15      


Thr Asn Ser Glu Thr Asn Arg Gly Glu Ser Glu Lys Lys Arg Asn Leu 
            20                  25                  30          


Gly Glu Leu Ser Arg Thr Thr Ser Glu Asp Asn Glu Val Phe Gly Glu 
        35                  40                  45              


Ala Asp Ala Asn Gln Asn Asn Gly Thr Ser Ser Gln Asp Thr Ala Val 
    50                  55                  60                  


Thr Asp Ser Lys Arg Thr Ala Asp Pro Lys Asn Ala Trp Gln Asp Ala 
65                  70                  75                  80  


His Pro Ala Asp Pro Gly Ser Arg Pro His Leu Ile Arg Leu Phe Ser 
                85                  90                  95      


Arg Asp Ala Pro Gly Arg Glu Asp Asn Thr Phe Lys Asp Arg Pro Ser 
            100                 105                 110         


Glu Ser Asp Glu Leu Gln Thr Ile Gln Glu Asp Ser Ala Ala Thr Ser 
        115                 120                 125             


Glu Ser Leu Asp Val Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His 
    130                 135                 140                 


Gly Ser Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His 
145                 150                 155                 160 


Gly Phe Leu Pro Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly 
                165                 170                 175     


Arg Phe Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys 
            180                 185                 190         


Val Ser Ser Glu Glu 
        195         


<210>  36
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 
1               5                   10                  15      


Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 
            20                  25                  30          


His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 
        35                  40                  45              


Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Val Pro Trp Leu Lys 
    50                  55                  60                  


Pro Gly Arg Ser Pro Leu Pro Ser His Ala Arg Ser Gln Pro Gly Leu 
65                  70                  75                  80  


Cys Asn Met Tyr Lys Asp Ser His His Pro Ala Arg Thr Ala His Tyr 
                85                  90                  95      


Gly Ser Leu Pro Gln Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro 
            100                 105                 110         


Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro 
        115                 120                 125             


Ser Gln Gly Lys Gly Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly 
    130                 135                 140                 


Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp 
145                 150                 155                 160 


Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr 
                165                 170                 175     


Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser 
            180                 185                 190         


Pro Met Ala Arg Arg 
        195         


<210>  37
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 
1               5                   10                  15      


Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 
            20                  25                  30          


His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 
        35                  40                  45              


Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Asp Ser His His Pro 
    50                  55                  60                  


Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln Lys Ser His Gly Arg 
65                  70                  75                  80  


Thr Gln Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr 
                85                  90                  95      


Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly Arg Gly Leu Ser Leu 
            100                 105                 110         


Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr 
        115                 120                 125             


Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly 
    130                 135                 140                 


Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg 
145                 150                 155                 160 


Asp Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 
                165                 170     


<210>  38
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 
1               5                   10                  15      


Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 
            20                  25                  30          


His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 
        35                  40                  45              


Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Asp Ser His His Pro 
    50                  55                  60                  


Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln Lys Ser His Gly Arg 
65                  70                  75                  80  


Thr Gln Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr 
                85                  90                  95      


Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly Ala Glu Gly Gln Arg 
            100                 105                 110         


Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His 
        115                 120                 125             


Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe 
    130                 135                 140                 


Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 
145                 150                 155                 160 


<210>  39
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 
1               5                   10                  15      


Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Ser Leu Pro Gln 
            20                  25                  30          


Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro Val Val His Phe Phe 
        35                  40                  45              


Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly 
    50                  55                  60                  


Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp 
65                  70                  


