                         SEQUENCE LISTING

<110>  Cephalon Australia Pty Ltd
       Poulton, Lynn
       Clarke, Adam
       Tamvakis, Debra
       Kopsidas, George
       Doyle, Anthony
       Jennings, Philip
       Pollard, Matthew
 
<120>  Antibodies against TL1a and uses thereof

<130>  512500

<150>  61/541590
<151>  2011-09-30

<150>  2011904042
<151>  2011-09-30

<160>  235   

<170>  PatentIn version 3.5

<210>  1
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp Asp Asp Asp Lys Gly Ser His His His His His His His His Gly 
1               5                   10                  15      


Ser Gly Ser Leu Val Pro Arg Gly Ser Gly Ser Leu Lys Gly Gln Glu 
            20                  25                  30          


Phe Ala Pro Ser His Gln Gln Val Tyr Ala Pro Leu Arg Ala Asp Gly 
        35                  40                  45              


Asp Lys Pro Arg Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln 
    50                  55                  60                  


His Phe Lys Asn Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly 
65                  70                  75                  80  


Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu 
                85                  90                  95      


Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg 
            100                 105                 110         


Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn 
        115                 120                 125             


Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr 
    130                 135                 140                 


Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val 
145                 150                 155                 160 


Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu 
                165                 170                 175     


Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val 
            180                 185                 190         


Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu 
        195                 200                 205         


<210>  2
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C336 VH

<400>  2

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Gly Gln Thr His Leu Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  3
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C336 HCDR1

<400>  3

Gly Tyr Tyr Met His 
1               5   


<210>  4
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C336 HCDR2

<400>  4

Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C336 HCDR3

<400>  5

Gly Gly Gln Thr His Leu Asp Val 
1               5               


<210>  6
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C336 VL

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Thr Asp Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Tyr Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
            100                 105             


<210>  7
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C336 LCDR1

<400>  7

Gln Ala Ser Gln Asp Ile Thr Asp Tyr Leu Asn 
1               5                   10      


<210>  8
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C336 LCDR2

<400>  8

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C336 LCDR3

<400>  9

Gln Gln Tyr Asp Asn Leu Pro Ile Thr 
1               5                   


<210>  10
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C334 VH

<400>  10

Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn His Ala Gln Ser Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Thr Asn Ser Tyr Ser Ser Ser Trp Tyr Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  11
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C334 HCDR1

<400>  11

Ser Tyr Thr Ile Ser 
1               5   


<210>  12
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C334 HCDR2

<400>  12

Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn His Ala Gln Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  13
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C334 HCDR3

<400>  13

Asn Ser Tyr Ser Ser Ser Trp Tyr Asp Ala Phe Asp Ile 
1               5                   10              


<210>  14
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C334 VL

<400>  14

Asp Val Val Met Thr Gln Ser Pro Ala Phe Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Met Pro Gly Gln Ala Pro Arg Leu Leu Leu 
        35                  40                  45              


Tyr Asp Ala Ser Thr Arg Ala Thr Asp Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Ser 
65                  70                  75                  80  


Ala Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  15
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C334 LCDR1

<400>  15

Arg Ala Ser Gln Ser Ile Ser Asn Asn Leu Ala 
1               5                   10      


<210>  16
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C334 LCDR2

<400>  16

Asp Ala Ser Thr Arg Ala Thr 
1               5           


<210>  17
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C334 LCDR3

<400>  17

Gln Gln Tyr Asn Asn Trp Pro Leu Thr 
1               5                   


<210>  18
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C333 VH

<400>  18

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Tyr Ala Gln Arg Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ser Thr Asn Ser Tyr Ser Ser Ser Trp Tyr Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  19
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C333 HCDR1

<400>  19

Ser Tyr Thr Ile Ser 
1               5   


<210>  20
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C333 HCDR2

<400>  20

Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Tyr Ala Gln Arg Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  21
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C333 HCDR3

<400>  21

Asn Ser Tyr Ser Ser Ser Trp Tyr Asp Ala Phe Asp Ile 
1               5                   10              


<210>  22
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C333 VL

<400>  22

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Thr Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Leu Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Arg Ala Thr Asp Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Thr Gly Ser Gly Ser Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Ser 
65                  70                  75                  80  


Ala Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys Arg 
            100                 105             


<210>  23
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C333 LCDR1

<400>  23

Arg Ala Ser Gln Ser Ile Thr Asn Asn Leu Ala 
1               5                   10      


<210>  24
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C333 LCDR2

<400>  24

Asp Ala Ser Thr Arg Ala Thr 
1               5           


<210>  25
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C333 LCDR3

<400>  25

Gln Gln Tyr Asn Asn Trp Pro Leu Thr 
1               5                   


<210>  26
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C323 VH

<400>  26

Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Tyr Ala Gln Arg Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ser Thr Asn Ser Tyr Ser Ser Ser Trp Tyr Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  27
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C323 HCDR1

<400>  27

Ser Tyr Thr Ile Ser 
1               5   


<210>  28
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C323 HCDR2

<400>  28

Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Tyr Ala Gln Arg Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  29
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C323 HCDR3

<400>  29

Asn Ser Tyr Ser Ser Ser Trp Tyr Asp Ala Phe Asp Ile 
1               5                   10              


<210>  30
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C323 VL

<400>  30

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Tyr Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Ser Tyr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  31
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C323 LCDR1

<400>  31

Arg Ala Ser Gln Gly Ile Gly Ser Ala Leu Ala 
1               5                   10      


<210>  32
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C323 LCDR2

<400>  32

Asp Ala Ser Ser Leu Gln Ser 
1               5           


<210>  33
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C323 LCDR3

<400>  33

Gln Gln Phe Ser Tyr Tyr Pro Leu Thr 
1               5                   


<210>  34
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C321 VH

<400>  34

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser His Ile Tyr Asp Ile Leu Thr Gly Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  35
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C321 HCDR1

<400>  35

Ser Tyr Gly Ile Ser 
1               5   


<210>  36
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C321 HCDR2

<400>  36

Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  37
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C321 HCDR3

<400>  37

Asp Ser His Ile Tyr Asp Ile Leu Thr Gly Tyr Asp Tyr 
1               5                   10              


<210>  38
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C321 VL

<400>  38

Asp Val Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys His Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Asp 
                85                  90                  95      


Thr Gln Phe Pro Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  39
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C321 LCDR1

<400>  39

His Ser Ser Gln Ser Leu Val His Ser Asp Gly Asn Thr Tyr Leu Ser 
1               5                   10                  15      


<210>  40
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C321 LCDR2

<400>  40

Lys Ile Ser Asn Arg Phe Ser 
1               5           


<210>  41
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C321 LCDR3

<400>  41

Met Gln Asp Thr Gln Phe Pro Gln Thr 
1               5                   


<210>  42
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C320 VH

<400>  42

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Asp Thr Ala Ser Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  43
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C320 HCDR1

<400>  43

Ser Tyr Asp Ile Asn 
1               5   


<210>  44
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C320 HCDR2

<400>  44

Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  45
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C320 HCDR3

<400>  45

Glu Val Pro Asp Thr Ala Ser Phe Glu Tyr 
1               5                   10  


<210>  46
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C320 VL

<400>  46

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ala Gly Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Leu Gly Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Leu Pro Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Thr 
                85                  90                  95      


Leu Ser Ala Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  47
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C320 LCDR1

<400>  47

Ala Gly Ser Ser Ser Asp Ile Gly Ala Gly Leu Gly Val His 
1               5                   10                  


<210>  48
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C320 LCDR2

<400>  48

Gly Tyr Tyr Asn Arg Pro Ser 
1               5           


<210>  49
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C320 LCDR3

<400>  49

Gln Ser Tyr Asp Gly Thr Leu Ser Ala Leu 
1               5                   10  


<210>  50
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C319 VH

<400>  50

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Arg 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Asp Ile Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Glu Ala Gly Gly Thr Tyr Ile Asp Ala Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  51
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C319 HCDR1

<400>  51

Ser Arg Asn Trp Trp Ser 
1               5       


<210>  52
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C319 HCDR2

<400>  52

Glu Ile Tyr His Ser Asp Ile Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  53
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C319 HCDR3

<400>  53

Asp Gly Glu Ala Gly Gly Thr Tyr Ile Asp Ala Phe Asp Val 
1               5                   10                  


<210>  54
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C319 VL

<400>  54

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ile Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Asp Val Ser Glu Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Asp Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Tyr Ala Gly Thr 
                85                  90                  95      


Tyr Thr Ser Leu Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110     


<210>  55
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C319 LCDR1

<400>  55

Thr Gly Thr Ser Ser Asp Val Gly Ile Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  56
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C319 LCDR2

<400>  56

Asp Val Ser Glu Arg Pro Ser 
1               5           


<210>  57
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C319 LCDR3

<400>  57

Tyr Ser Tyr Ala Gly Thr Tyr Thr Ser Leu 
1               5                   10  


<210>  58
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-3 VH

<400>  58

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Asp Thr Ala Ser Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  59
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-3 HCDR1

<400>  59

Ser Tyr Asp Ile Asn 
1               5   


<210>  60
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-3 HCDR2

<400>  60

Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  61
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-3 HCDR3

<400>  61

Glu Val Pro Asp Thr Ala Ser Phe Glu Tyr 
1               5                   10  


<210>  62
<211>  111
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-5 VL

<400>  62

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ala Gly Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Leu Gly Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Thr Ile Thr Gly Leu 
65                  70                  75                  80  


Leu Pro Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Thr 
                85                  90                  95      


Leu Ser Ala Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  63
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-5 LCDR1

<400>  63

Ala Gly Ser Ser Ser Asp Ile Gly Ala Gly Leu Gly Val His 
1               5                   10                  


<210>  64
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-5 LCDR2

<400>  64

Gly Tyr Tyr Asn Arg Pro Ser 
1               5           


<210>  65
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-5 LCDR3

<400>  65

Gln Ser Tyr Asp Gly Thr Leu Ser Ala Leu 
1               5                   10  


<210>  66
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-90 VH

<400>  66

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Asp Asp Ala Ser Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  67
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-90 HCDR1

<400>  67

Ser Tyr Asp Ile Asn 
1               5   


<210>  68
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-90 HCDR2

<400>  68

Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  69
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-90 HCDR3

<400>  69

Glu Val Pro Asp Asp Ala Ser Phe Glu Tyr 
1               5                   10  


<210>  70
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-103 VH

<400>  70

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Asp Thr Ala Ala Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  71
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-103 HCDR1

<400>  71

Ser Tyr Asp Ile Asn 
1               5   


<210>  72
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-103 HCDR2

<400>  72

Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  73
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-103 HCDR3

<400>  73

Glu Val Pro Asp Thr Ala Ala Phe Glu Tyr 
1               5                   10  


<210>  74
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-114 VH

<400>  74

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Asp Thr Ala Ser Phe Leu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  75
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-114 HCDR1

<400>  75

Ser Tyr Asp Ile Asn 
1               5   


<210>  76
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-114 HCDR2

<400>  76

Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  77
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-114 HCDR3

<400>  77

Glu Val Pro Asp Thr Ala Ser Phe Leu Tyr 
1               5                   10  


<210>  78
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-115 VH

<400>  78

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Asp Thr Ala Ser Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  79
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-115 HCDR1

<400>  79

Ser Tyr Asp Ile Asn 
1               5   


<210>  80
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-115 HCDR2

<400>  80

Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  81
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-115 HCDR3

<400>  81

Glu Val Pro Asp Thr Ala Ser Phe Asp Tyr 
1               5                   10  


<210>  82
<211>  111
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-120 VL

<400>  82

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Leu Gly Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Leu Pro Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Thr 
                85                  90                  95      


Leu Ser Ala Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  83
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-120 LCDR1

<400>  83

Thr Gly Ser Ser Ser Asp Ile Gly Ala Gly Leu Gly Val His 
1               5                   10                  


<210>  84
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-120 LCDR2

<400>  84

Gly Tyr Tyr Asn Arg Pro Ser 
1               5           


<210>  85
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-120 LCDR3

<400>  85

Gln Ser Tyr Asp Gly Thr Leu Ser Ala Leu 
1               5                   10  


<210>  86
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-129 VH

<400>  86

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Glu Thr Ala Ser Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  87
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-129 HCDR1

<400>  87

Ser Tyr Asp Ile Asn 
1               5   


<210>  88
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-129 HCDR2

<400>  88

Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  89
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-129 HCDR3

<400>  89

Glu Val Pro Glu Thr Ala Ser Phe Glu Tyr 
1               5                   10  


<210>  90
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-130 VH

<400>  90

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Asp Thr Ala Ser Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  91
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-130 HCDR1

<400>  91

Ser Tyr Asp Ile Asn 
1               5   


<210>  92
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of C320-130 HCDR2

<400>  92

Trp Leu Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  93
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of C320-130 HCDR3

<400>  93

Glu Val Pro Asp Thr Ala Ser Phe Glu Tyr 
1               5                   10  


<210>  94
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of VH consensus sequence of C320 and 
       derivatives


<220>
<221>  VARIANT
<222>  (41)..(41)
<223>  X=T or P

<220>
<221>  VARIANT
<222>  (51)..(51)
<223>  X=M or L

<220>
<221>  VARIANT
<222>  (102)..(102)
<223>  X=E or D

<220>
<221>  VARIANT
<222>  (103)..(103)
<223>  X=T or D

<220>
<221>  VARIANT
<222>  (105)..(105)
<223>  X=S or A

<220>
<221>  VARIANT
<222>  (107)..(107)
<223>  X=L or D or E

<400>  94

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Xaa Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Xaa Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Xaa Xaa Ala Xaa Phe Xaa Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  95
<211>  111
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of VL consensus sequence of C320 and 
       derivatives


<220>
<221>  VARIANT
<222>  (23)..(23)
<223>  X=A or T

<220>
<221>  VARIANT
<222>  (76)..(76)
<223>  X=A or T

<400>  95

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Xaa Gly Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Leu Gly Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Xaa Ile Thr Gly Leu 
65                  70                  75                  80  


Leu Pro Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Thr 
                85                  90                  95      


Leu Ser Ala Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  96
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding VH of C336

<400>  96
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc ggctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaacccta acagtggtgg cacaaactat      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc gagtgggggc      300

cagacccacc tggacgtctg gggccaaggg accacggtca ccgtctcctc a               351


<210>  97
<211>  324
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding VL of C336

<400>  97
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattacc gactatttaa attggtatca gcagagacca      120

gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggttccatca      180

aggttcagtg gaagtggatc tgggacatat tttactttca ccatcagcag cctgcagcct      240

gaagattttg cgacatatta ctgtcaacag tatgataatc tcccgatcac cttcggccag      300

gggacacgac tggagattaa acgt                                             324


<210>  98
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding VH of C334

<400>  98
caaatgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatacta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaaccac      180

gcacagagct tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtat attattgttc aaccaactcg      300

tatagcagca gctggtatga tgcttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcttca                                                                 366


<210>  99
<211>  324
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding VL of C334

<400>  99
gatgttgtga tgacacagtc tccagctttc ctctctgtgt ctcctgggga aagagccacc       60

ctctcctgca gggccagtca gagtattagc aacaacttag cctggtatca gcaaatgcct      120

ggccaggctc ccaggctcct tctttatgat gcatccacca gggccactga tatcccagcc      180

aggttcagtg gcagtgggtc tgggtcagag ttcactctca ccatcagcgg cctgcagtct      240

gcagattttg cagtttatta ctgtcaacaa tacaataact ggcctctcac tttcggcgga      300

gggaccaagc tggagatcaa acgt                                             324


<210>  100
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding VH of C333

<400>  100
caggtccagc ttgtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatacta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac aacaaactac      180

gcacagaggt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccatat attactgttc aaccaactcc      300

tatagcagca gctggtatga tgcttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcttca                                                                 366


<210>  101
<211>  324
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding VL of C333

<400>  101
gaaattgtgt tgacgcagtc tccagccacc ctgtctgtgt ctcctgggga aagagccacc       60

ctctcctgca gggccagtca gagtattacc aacaacttag cctggtatca acaactgcct      120

ggccaggctc ccaggctcct tatttacgat gcatccacca gggccactga tatcccagcc      180

aggttcagtg gcactgggtc tgggtcagag ttcactctca ccatcagcgg cctgcagtct      240

gcggattttg cagtttatta ctgtcaacaa tacaataact ggcctctcac tttcggcgga      300

gggaccaaag tggatatcaa acgt                                             324


<210>  102
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding VH of C323

<400>  102
caaatgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatacta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac aacaaactac      180

gcacagaggt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccatat attactgttc aaccaactcc      300

tatagcagca gctggtatga tgcttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcttca                                                                 366


<210>  103
<211>  324
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding VL of C323

<400>  103
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gcgcaagtca gggcattggc agtgctttag cctggtatca gcagaaacca      120

gggaaagctc ctaagctcct gatctatgat gcctccagtt tgcaaagtgg ggtcccatca      180

aggtacagcg gcagtggatc tgggacagat ttcactctca ccatcagcgg cctgcagcct      240

gaagattttg caacttatta ctgtcaacag tttagttatt acccgctcac tttcggcgga      300

gggaccaagc tggagatcaa acgt                                             324


<210>  104
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding VH of C321

<400>  104
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc agctatggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatggtaa cacaaactat      180

gcacagaagc tccagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagactcc      300

catatttacg atattttgac tggttatgac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  105
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding VL of C321

<400>  105
gatgttgtga tgacacagac tccactctcc tcacctgtca cccttggaca gccggcctcc       60

atctcctgcc actctagtca aagcctcgta cacagtgatg gaaacaccta cttgagttgg      120

cttcagcaga ggcccggcca gcctccaaga ctcctaattt ataagatttc taaccggttc      180

tctggggtcc cagacagatt cagtggcagt ggggcaggga cagatttcac actgaaaatc      240

agcagggtgg aagctgagga tgtcggggtt tattactgca tgcaagatac acaatttcct      300

cagacgttcg gccaagggac caaggtggaa atcaaacgt                             339


<210>  106
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding VH of C320

<400>  106
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc agttatgata tcaactgggt gcgacaggcc      120

actggacaag ggcttgagtg gatgggatgg atgaacccta acagtggtaa cacaggctat      180

gcacagaagt tccagggcag agtcaccatg accaggaaca cctccataag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagaagtg      300

cctgatacgg cctcctttga gtactggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  107
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding VL of C320

<400>  107
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcgctg ggagtagttc cgacatcggg gcaggtcttg gcgtgcactg gtatcagcag      120

cttccaggaa cagcccccaa actcctcatc tatggttact acaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

ctgcctgagg atgagggtga ttattactgc cagtcctatg acggcactct gagtgcccta      300

ttcggcggag ggaccaagct gaccgtccta ggt                                   333


<210>  108
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding VH of C319

<400>  108
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggggac cctgtccctc       60

acctgcgctg tctctggtgg ctccatcagc agtagaaact ggtggagttg ggtccgccag      120

tccccaggga aggggctgga gtggattggg gaaatctatc acagtgatat aaccaactat      180

aacccgtccc tcaagagtcg agtcaccatt tcagtagaca agtccaagaa ccagttctcc      240

ctgaagctga gctctgtgac cgccgcggac acggccgtgt attactgtgc gaaggacggg      300

gaggcgggcg ggacctacat tgatgctttt gatgtctggg gccaagggac aatggtcacc      360

gtctcttca                                                              369


<210>  109
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding VL of C319

<400>  109
cagtctgccc tgactcagcc tcgctcagtg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gaaccagcag tgatgttggt atttataact atgtctcctg gtaccaacaa      120

cacccaggca aagcccccaa actcataatt tatgatgtca gtgagcggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctgac aacacggcct ccctgaccat ctctgggctc      240

caggctgagg atgaggctga ttattactgc tactcatatg caggcaccta cacttcctta      300

ttcggcggag ggaccaaggt caccgtccta ggt                                   333


<210>  110
<211>  357
<212>  DNA
<213>  artificial

<220>
<223>  nucleotide sequence encoding VH of C320-3

<400>  110
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc agttatgata tcaactgggt gcgacaggcc      120

cccggacaag ggcttgagtg gatgggatgg atgaacccta acagtggtaa cacaggctat      180

gcacagaagt tccagggcag agtcaccatg accaggaaca cctccataag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagaagtg      300

cctgatacgg cctcctttga gtactggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  111
<211>  333
<212>  DNA
<213>  artificial

<220>
<223>  nucleotide sequence encoding VL of C320-5

<400>  111
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcgctg ggagtagttc cgacatcggg gcaggtcttg gcgtgcactg gtatcagcag      120

cttccaggaa cagcccccaa actcctcatc tatggttact acaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctgaccat cactgggctc      240

ctgcctgagg atgagggtga ttattactgc cagtcctatg acggcactct gagtgcccta      300

ttcggcggag ggaccaagct gaccgtccta ggt                                   333


<210>  112
<211>  357
<212>  DNA
<213>  artificial

<220>
<223>  nucleotide sequence encoding VH of C320-90

<400>  112
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcgccag cgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc agctacgaca tcaactgggt ccgacaggcc      120

accggccagg gcctggaatg gatgggctgg atgaacccca acagcggcaa caccggctac      180

gcccagaaat tccagggcag agtgaccatg acccggaaca ccagcatcag caccgcctac      240

atggaactga gcagcctgcg gagcgaggac accgccgtgt actactgcgc cagagaggtg      300

cccgacgacg ccagcttcga gtattggggc cagggcaccc tggtcaccgt gtctagc         357


<210>  113
<211>  357
<212>  DNA
<213>  artificial

<220>
<223>  nucleotide sequence encoding VH of C320-103

<400>  113
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcgccag cgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc agctacgaca tcaactgggt ccgacaggcc      120

accggccagg gcctggaatg gatgggctgg atgaacccca acagcggcaa caccggctac      180

gcccagaaat tccagggcag agtgaccatg acccggaaca ccagcatcag caccgcctac      240

atggaactga gcagcctgcg gagcgaggac accgccgtgt actactgcgc cagagaggtg      300

cccgacaccg ccgccttcga gtattggggc cagggcaccc tggtcaccgt gtctagc         357


<210>  114
<211>  357
<212>  DNA
<213>  artificial

<220>
<223>  nucleotide sequence encoding VH of C320-114

<400>  114
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcgccag cgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc agctacgaca tcaactgggt ccgacaggcc      120

accggccagg gcctggaatg gatgggctgg atgaacccca acagcggcaa caccggctac      180

gcccagaaat tccagggcag agtgaccatg acccggaaca ccagcatcag caccgcctac      240

atggaactga gcagcctgcg gagcgaggac accgccgtgt actactgcgc cagagaggtg      300

cccgacaccg ccagcttcct gtattggggc cagggcaccc tggtcaccgt gtctagc         357


<210>  115
<211>  357
<212>  DNA
<213>  artificial

<220>
<223>  nucleotide sequence encoding VH of C320-115

<400>  115
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcgccag cgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc agctacgaca tcaactgggt ccgacaggcc      120

accggccagg gcctggaatg gatgggctgg atgaacccca acagcggcaa caccggctac      180

gcccagaaat tccagggcag agtgaccatg acccggaaca ccagcatcag caccgcctac      240

atggaactga gcagcctgcg gagcgaggac accgccgtgt actactgcgc cagagaggtg      300

cccgacaccg ccagcttcga ctattggggc cagggcaccc tggtcaccgt gtctagc         357


<210>  116
<211>  333
<212>  DNA
<213>  artificial

<220>
<223>  nucleotide sequence encoding VL of C320-120

<400>  116
cagagcgtgc tgacacagcc ccctagcgtg tcaggcgccc ctggccagag agtgaccatc       60

tcttgcaccg gcagcagcag cgacatcgga gctggactgg gcgtgcactg gtatcagcag      120

ctgcctggca ccgcccccaa gctgctgatc tacggctact acaaccggcc cagcggcgtg      180

cccgacagat tcagcggcag caagagcggc accagcgcca gcctggccat cactggactg      240

ctgcccgagg acgagggcga ctactactgc cagagctacg acggcaccct gagcgccctg      300

tttggcggag gcaccaagct gaccgtccta ggt                                   333


<210>  117
<211>  357
<212>  DNA
<213>  artificial

<220>
<223>  nucleotide sequence encoding VH of C320-129

<400>  117
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc agttatgata tcaactgggt gcgacaggcc      120

actggacaag ggcttgagtg gatgggatgg atgaacccta acagtggtaa cacaggctat      180

gcacagaagt tccagggcag agtcaccatg accaggaaca cctccataag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagaagtg      300

cctgagacgg cctcctttga gtactggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  118
<211>  357
<212>  DNA
<213>  artificial

<220>
<223>  nucleotide sequence encoding VH of C320-130

<400>  118
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc agttatgata tcaactgggt gcgacaggcc      120

actggacaag ggcttgagtg gatgggatgg ctgaacccta acagtggtaa cacaggctat      180

gcacagaagt tccagggcag agtcaccatg accaggaaca cctccataag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagaagtg      300

cctgatacgg cctcctttga gtactggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  119
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of VH of humanized antibody 1B4

<400>  119

Gln Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Asn Met Gly Val Val Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Leu Trp Asp Asp Arg Glu Tyr Ser Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met Ser Arg Asn Tyr Tyr Gly Ser Ser Tyr Val Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  120
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of VL of humanized antibody 1B4

<400>  120

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Asn Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Trp Asn Asn Tyr Gly Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105     


<210>  121
<211>  372
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding VH of humanized antibody 1B4

<400>  121
caggtcacac tgaaagagtc cggccctgcc ctggtcaagc ccacccagac cctgaccctg       60

acatgcacct tcagcggctt cagcctgagc accagcaaca tgggcgtcgt gtggatcaga      120

cagccccctg gcaaggccct ggaatggctg gcccacatcc tgtgggacga cagagagtac      180

agcaaccccg ccctgaagtc ccggctgacc atcagcaagg acaccagcaa gaaccaggtg      240

gtgctgacca tgaccaacat ggaccccgtg gacaccgcca cctactactg cgcccggatg      300

agccggaact actacggcag cagctacgtg atggactact ggggccaggg caccctggtc      360

accgtgtcct ca                                                          372


<210>  122
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding VL of humanized antibody 1B4

<400>  122
gacatccagc tgacccagag ccccagcttc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgta gcgccagcag cagcgtgaac tacatgcact ggtatcagca gaagcccggc      120

aaggccccca agctgctgat ctacagcacc agcaacctgg ccagcggcgt gcccagcaga      180

ttttctggca gcggcagcgg caccgagttc accctgacca tcagcagcct gcagcccgag      240

gacttcgcca cctactactg ccaccagtgg aacaactacg gcaccttcgg ccagggcacc      300

aaggtggaaa tcaagcgt                                                    318


<210>  123
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Ala Glu Asp Leu Gly Leu Ser Phe Gly Glu Thr Ala Ser Val Glu 
1               5                   10                  15      


Met Leu Pro Glu His Gly Ser Cys Arg Pro Lys Ala Arg Ser Ser Ser 
            20                  25                  30          


Ala Arg Trp Ala Leu Thr Cys Cys Leu Val Leu Leu Pro Phe Leu Ala 
        35                  40                  45              


Gly Leu Thr Thr Tyr Leu Leu Val Ser Gln Leu Arg Ala Gln Gly Glu 
    50                  55                  60                  


Ala Cys Val Gln Phe Gln Ala Leu Lys Gly Gln Glu Phe Ala Pro Ser 
65                  70                  75                  80  


His Gln Gln Val Tyr Ala Pro Leu Arg Ala Asp Gly Asp Lys Pro Arg 
                85                  90                  95      


Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln His Phe Lys Asn 
            100                 105                 110         


Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly Leu Ala Phe Thr 
        115                 120                 125             


Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser 
    130                 135                 140                 


Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser 
145                 150                 155                 160 


Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser 
                165                 170                 175     


Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr 
            180                 185                 190         


Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val Gly Ser Asn Trp 
        195                 200                 205             


Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu Gln Glu Gly Asp 
    210                 215                 220                 


Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys 
225                 230                 235                 240 


Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu 
                245                 250     


<210>  124
<211>  177
<212>  PRT
<213>  Mus musculus

<400>  124

Ile Thr Glu Glu Arg Ser Glu Pro Ser Pro Gln Gln Val Tyr Ser Pro 
1               5                   10                  15      


Pro Arg Gly Lys Pro Arg Ala His Leu Thr Ile Lys Lys Gln Thr Pro 
            20                  25                  30          


Ala Pro His Leu Lys Asn Gln Leu Ser Ala Leu His Trp Glu His Asp 
        35                  40                  45              


Leu Gly Met Ala Phe Thr Lys Asn Gly Met Lys Tyr Ile Asn Lys Ser 
    50                  55                  60                  


Leu Val Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln Ile Thr 
65                  70                  75                  80  


Phe Arg Gly Thr Thr Ser Val Cys Gly Asp Ile Ser Arg Gly Arg Arg 
                85                  90                  95      


Pro Asn Lys Pro Asp Ser Ile Thr Met Val Ile Thr Lys Val Ala Asp 
            100                 105                 110         


Ser Tyr Pro Glu Pro Ala Arg Leu Leu Thr Gly Ser Lys Ser Val Cys 
        115                 120                 125             


Glu Ile Ser Asn Asn Trp Phe Gln Ser Leu Tyr Leu Gly Ala Thr Phe 
    130                 135                 140                 


Ser Leu Glu Glu Gly Asp Arg Leu Met Val Asn Val Ser Asp Ile Ser 
145                 150                 155                 160 


Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu 
                165                 170                 175     


Leu 
    


<210>  125
<211>  180
<212>  PRT
<213>  Macaca mulatta

<400>  125

Leu Lys Gly Gln Glu Phe Ala Pro Ser His Gln Gln Val Tyr Ala Pro 
1               5                   10                  15      


Leu Arg Ala Asp Gly Asp Lys Pro Arg Ala His Leu Thr Val Val Arg 
            20                  25                  30          


Gln Thr Pro Thr Gln His Leu Lys Asn Gln Phe Pro Ala Leu His Trp 
        35                  40                  45              


Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr 
    50                  55                  60                  


Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Val Tyr Ser 
65                  70                  75                  80  


Gln Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln 
                85                  90                  95      


Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys 
            100                 105                 110         


Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys 
        115                 120                 125             


Ser Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly 
    130                 135                 140                 


Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser 
145                 150                 155                 160 


Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly 
                165                 170                 175     


Ala Phe Leu Leu 
            180 


<210>  126
<211>  177
<212>  PRT
<213>  Rattus rattus

<400>  126

Val Thr Glu Glu Arg Ser Ala Pro Ser Ala Gln Pro Val Tyr Thr Pro 
1               5                   10                  15      


Ser Arg Asp Lys Pro Lys Ala His Leu Thr Ile Met Arg Gln Thr Pro 
            20                  25                  30          


Val Pro His Leu Lys Asn Glu Leu Ala Ala Leu His Trp Glu Asn Asn 
        35                  40                  45              


Leu Gly Met Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe 
    50                  55                  60                  


Leu Val Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln Ile Thr 
65                  70                  75                  80  


Phe Arg Gly Thr Thr Ser Glu Cys Gly Asp Ile Ser Arg Val Arg Arg 
                85                  90                  95      


Pro Lys Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys Val Ala Asp 
            100                 105                 110         


Ser Tyr Pro Glu Pro Ala His Leu Leu Thr Gly Thr Lys Ser Val Cys 
        115                 120                 125             


Glu Ile Ser Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe 
    130                 135                 140                 


Ser Leu Glu Glu Gly Asp Arg Leu Met Val Asn Val Ser Asp Ile Ser 
145                 150                 155                 160 


Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu 
                165                 170                 175     


Ile 
    


<210>  127
<211>  179
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  127

Leu Lys Gly Arg Glu Phe Gly Pro Ser Gln Gln Arg Ala Tyr Met Pro 
1               5                   10                  15      


Leu Arg Ala Asp Gly Asn Lys Pro Arg Ala His Leu Thr Ala Val Lys 
            20                  25                  30          


Gln Thr Pro Thr Gln Pro Leu Arg Asn His Phe Pro Ala Leu His Trp 
        35                  40                  45              


Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr 
    50                  55                  60                  


Asn Lys Phe Leu Val Ile Pro Glu Ser Gly Asp Tyr Phe Val Tyr Ser 
65                  70                  75                  80  


Gln Val Thr Phe Arg Gly Thr Thr Ser Glu Cys Gly Val Ile Asn Gln 
                85                  90                  95      


Arg Arg Arg Gln Thr Lys Pro Asp Ser Ile Val Val Val Ile Thr Lys 
            100                 105                 110         


Val Thr Asp Asn Tyr Pro Glu Pro Ala Gln Leu Leu Thr Gly Thr Lys 
        115                 120                 125             


Ser Val Cys Glu Met Gly Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala 
    130                 135                 140                 


Met Phe Ser Leu Glu Glu Gly Asp Lys Leu Met Val Asn Val Ser Asp 
145                 150                 155                 160 


Val Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala 
                165                 170                 175     


Phe Leu Leu 
            


<210>  128
<211>  180
<212>  PRT
<213>  Cavia porcellus

<400>  128

Thr Ile Asn Glu Gln Arg Phe Gly Pro Ser Tyr Gln Arg Val Tyr Thr 
1               5                   10                  15      


Pro Leu Arg Asp Asp Arg Asp Lys Pro Arg Ala His Leu Thr Val Val 
            20                  25                  30          


Arg Gln Thr Pro Thr Gln His Leu Lys Asn Gln Phe Pro Ala Leu His 
        35                  40                  45              


Trp Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr 
    50                  55                  60                  


Thr Asn Lys Phe Leu Val Ile Pro Glu Thr Gly Asp Tyr Phe Val Tyr 
65                  70                  75                  80  


Ser Gln Ile Thr Phe Arg Gly Thr Thr Ser Glu Cys Gly Ile Ser Pro 
                85                  90                  95      


Gly Arg Gln Gln Asn Lys Pro Asp Ser Ile Phe Val Val Ile Thr Lys 
            100                 105                 110         


Val Thr Asp Ser Tyr Pro Glu Pro Ser Gln Leu Leu Thr Gly Thr Lys 
        115                 120                 125             


Ser Val Cys Glu Ile Ser Ser Asn Trp Phe Gln Pro Leu Tyr Leu Gly 
    130                 135                 140                 


Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser 
145                 150                 155                 160 


Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly 
                165                 170                 175     


Ala Phe Leu Leu 
            180 


<210>  129
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Glu Gln Arg Pro Arg Gly Cys Ala Ala Val Ala Ala Ala Leu Leu 
1               5                   10                  15      


Leu Val Leu Leu Gly Ala Arg Ala Gln Gly Gly Thr Arg Ser Pro Arg 
            20                  25                  30          


Cys Asp Cys Ala Gly Asp Phe His Lys Lys Ile Gly Leu Phe Cys Cys 
        35                  40                  45              


Arg Gly Cys Pro Ala Gly His Tyr Leu Lys Ala Pro Cys Thr Glu Pro 
    50                  55                  60                  


Cys Gly Asn Ser Thr Cys Leu Val Cys Pro Gln Asp Thr Phe Leu Ala 
65                  70                  75                  80  


Trp Glu Asn His His Asn Ser Glu Cys Ala Arg Cys Gln Ala Cys Asp 
                85                  90                  95      


Glu Gln Ala Ser Gln Val Ala Leu Glu Asn Cys Ser Ala Val Ala Asp 
            100                 105                 110         


Thr Arg Cys Gly Cys Lys Pro Gly Trp Phe Val Glu Cys Gln Val Ser 
        115                 120                 125             


Gln Cys Val Ser Ser Ser Pro Phe Tyr Cys Gln Pro Cys Leu Asp Cys 
    130                 135                 140                 


Gly Ala Leu His Arg His Thr Arg Leu Leu Cys Ser Arg Arg Gly Thr 
145                 150                 155                 160 


Asp Cys Gly Thr Cys Leu Pro Gly Phe Tyr Glu His Gly Asp Gly Cys 
                165                 170                 175     


Val Ser Cys Pro Thr Ser Thr Leu Gly Ser Cys Pro Glu Arg Cys Ala 
            180                 185                 190         


Ala Val Cys Gly Trp Arg Gln Met Phe Trp Val Gln Val Leu Leu Ala 
        195                 200                 205             


Gly Leu Val Val Pro Leu Leu Leu Gly Ala Thr Leu Thr Tyr Thr Tyr 
    210                 215                 220                 


Arg His Cys Trp Pro His Lys Pro Leu Val Thr Ala Asp Glu Ala Gly 
225                 230                 235                 240 


Met Glu Ala Leu Thr Pro Pro Pro Ala Thr His Leu Ser Pro Leu Asp 
                245                 250                 255     


Ser Ala His Thr Leu Leu Ala Pro Pro Asp Ser Ser Glu Lys Ile Cys 
            260                 265                 270         


Thr Val Gln Leu Val Gly Asn Ser Trp Thr Pro Gly Tyr Pro Glu Thr 
        275                 280                 285             


Gln Glu Ala Leu Cys Pro Gln Val Thr Trp Ser Trp Asp Gln Leu Pro 
    290                 295                 300                 


Ser Arg Ala Leu Gly Pro Ala Ala Ala Pro Thr Leu Ser Pro Glu Ser 
305                 310                 315                 320 


Pro Ala Gly Ser Pro Ala Met Met Leu Gln Pro Gly Pro Gln Leu Tyr 
                325                 330                 335     


Asp Val Met Asp Ala Val Pro Ala Arg Arg Trp Lys Glu Phe Val Arg 
            340                 345                 350         


Thr Leu Gly Leu Arg Glu Ala Glu Ile Glu Ala Val Glu Val Glu Ile 
        355                 360                 365             


Gly Arg Phe Arg Asp Gln Gln Tyr Glu Met Leu Lys Arg Trp Arg Gln 
    370                 375                 380                 


Gln Gln Pro Ala Gly Leu Gly Ala Val Tyr Ala Ala Leu Glu Arg Met 
385                 390                 395                 400 


Gly Leu Asp Gly Cys Val Glu Asp Leu Arg Ser Arg Leu Gln Arg Gly 
                405                 410                 415     


Pro 
    


<210>  130
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Arg Ala Leu Glu Gly Pro Gly Leu Ser Leu Leu Cys Leu Val Leu 
1               5                   10                  15      


Ala Leu Pro Ala Leu Leu Pro Val Pro Ala Val Arg Gly Val Ala Glu 
            20                  25                  30          


Thr Pro Thr Tyr Pro Trp Arg Asp Ala Glu Thr Gly Glu Arg Leu Val 
        35                  40                  45              


Cys Ala Gln Cys Pro Pro Gly Thr Phe Val Gln Arg Pro Cys Arg Arg 
    50                  55                  60                  


Asp Ser Pro Thr Thr Cys Gly Pro Cys Pro Pro Arg His Tyr Thr Gln 
65                  70                  75                  80  


Phe Trp Asn Tyr Leu Glu Arg Cys Arg Tyr Cys Asn Val Leu Cys Gly 
                85                  90                  95      


Glu Arg Glu Glu Glu Ala Arg Ala Cys His Ala Thr His Asn Arg Ala 
            100                 105                 110         


Cys Arg Cys Arg Thr Gly Phe Phe Ala His Ala Gly Phe Cys Leu Glu 
        115                 120                 125             


His Ala Ser Cys Pro Pro Gly Ala Gly Val Ile Ala Pro Gly Thr Pro 
    130                 135                 140                 


Ser Gln Asn Thr Gln Cys Gln Pro Cys Pro Pro Gly Thr Phe Ser Ala 
145                 150                 155                 160 


Ser Ser Ser Ser Ser Glu Gln Cys Gln Pro His Arg Asn Cys Thr Ala 
                165                 170                 175     


Leu Gly Leu Ala Leu Asn Val Pro Gly Ser Ser Ser His Asp Thr Leu 
            180                 185                 190         


Cys Thr Ser Cys Thr Gly Phe Pro Leu Ser Thr Arg Val Pro Gly Ala 
        195                 200                 205             


Glu Glu Cys Glu Arg Ala Val Ile Asp Phe Val Ala Phe Gln Asp Ile 
    210                 215                 220                 


Ser Ile Lys Arg Leu Gln Arg Leu Leu Gln Ala Leu Glu Ala Pro Glu 
225                 230                 235                 240 


Gly Trp Gly Pro Thr Pro Arg Ala Gly Arg Ala Ala Leu Gln Leu Lys 
                245                 250                 255     


Leu Arg Arg Arg Leu Thr Glu Leu Leu Gly Ala Gln Asp Gly Ala Leu 
            260                 265                 270         


Leu Val Arg Leu Leu Gln Ala Leu Arg Val Ala Arg Met Pro Gly Leu 
        275                 280                 285             


Glu Arg Ser Val Arg Glu Arg Phe Leu Pro Val His 
    290                 295                 300 


<210>  131
<211>  2
<212>  PRT
<213>  Artificial

<220>
<223>  sequence from TL1a

<400>  131

Leu Ala 
1       


<210>  132
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  sequence from TL1a

<400>  132

Gln Pro Ile Tyr 
1               


<210>  133
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  sequence from TL1a

<400>  133

Asn Val Ser Asp Ile Ser Leu 
1               5           


<210>  134
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  134

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  135
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  135

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  136
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  136

Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
            20                  25                  30          


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
        35                  40                  45              


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
    50                  55                  60                  


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
65                  70                  75                  80  


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
                85                  90                  95      


Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105 


<210>  137
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH consensus sequence of C320 and derivatives


<220>
<221>  X
<222>  (1)..(1)
<223>  X=Q or E

<220>
<221>  X
<222>  (4)..(4)
<223>  X=L or V

<220>
<221>  X
<222>  (5)..(5)
<223>  X=V or L or Q

<220>
<221>  X
<222>  (6)..(6)
<223>  X=L or absent

<220>
<221>  X
<222>  (7)..(7)
<223>  X=Q or E

<220>
<221>  X
<222>  (13)..(13)
<223>  X=K or R

<220>
<221>  X
<222>  (14)..(14)
<223>  X=K or R or A

<220>
<221>  X
<222>  (17)..(17)
<223>  X=A or S

<220>
<221>  X
<222>  (20)..(20)
<223>  X=K or T or Q or R

<220>
<221>  X
<222>  (24)..(24)
<223>  X=K or T

<220>
<221>  X
<222>  (25)..(25)
<223>  X=A or S or V

<220>
<221>  X
<222>  (42)..(42)
<223>  X=T or P

<220>
<221>  X
<222>  (44)..(44)
<223>  X=Q or R or H or K

<220>
<221>  X
<222>  (46)..(46)
<223>  X=L or P

<220>
<221>  X
<222>  (47)..(47)
<223>  X=E or Q

<220>
<221>  X
<222>  (49)..(49)
<223>  X=M or L

<220>
<221>  X
<222>  (52)..(52)
<223>  X=M or L

<220>
<221>  X
<222>  (69)..(69)
<223>  X=V or I or L

<220>
<221>  X
<222>  (70)..(70)
<223>  X=T or S

<220>
<221>  X
<222>  (71)..(71)
<223>  X=M or I or F

<220>
<221>  X
<222>  (73)..(73)
<223>  X=R or A or T or E

<220>
<221>  X
<222>  (74)..(74)
<223>  X=N or D

<220>
<221>  X
<222>  (75)..(75)
<223>  X=T or R or Q or E or D

<220>
<221>  X
<222>  (76)..(76)
<223>  X=S or A or F

<220>
<221>  X
<222>  (77)..(77)
<223>  X=I ot T or A

<220>
<221>  X
<222>  (78)..(78)
<223>  X=S or R or G or N

<220>
<221>  X
<222>  (80)..(80)
<223>  X=A or V

<220>
<221>  X
<222>  (82)..(82)
<223>  X=M or L

<220>
<221>  X
<222>  (83)..(83)
<223>  X=E or D

<220>
<221>  X
<222>  (85)..(85)
<223>  X=S or N or T or R

<220>
<221>  X
<222>  (86)..(86)
<223>  X=S or N

<220>
<221>  X
<222>  (89)..(89)
<223>  X=S or P or Y

<220>
<221>  X
<222>  (90)..(90)
<223>  X=E or D

<220>
<221>  X
<222>  (94)..(94)
<223>  X=V or M

<220>
<221>  X
<222>  (98)..(98)
<223>  X=A or T

<220>
<221>  X
<222>  (99)..(99)
<223>  X=R or K or T

<220>
<221>  X
<222>  (101)..(101)
<223>  X=V or A or S or H or L or D or Y or P or Q or K

<220>
<221>  X
<222>  (103)..(103)
<223>  X=E or D or A or S or H or K

<220>
<221>  X
<222>  (104)..(104)
<223>  X=T or D or A or S or D or Y

<220>
<221>  X
<222>  (106)..(106)
<223>  X=S or A or H or L or D or Y

<220>
<221>  X
<222>  (108)..(108)
<223>  X=L or D or E or A or S or H or P or Q or K

<220>
<221>  X
<222>  (112)..(112)
<223>  X=Q or K

<220>
<221>  X
<222>  (115)..(115)
<223>  X=L or T

<400>  137

Xaa Val Gln Xaa Xaa Xaa Xaa Ser Gly Ala Glu Val Xaa Xaa Pro Gly 
1               5                   10                  15      


Xaa Ser Val Xaa Val Ser Cys Xaa Xaa Ser Gly Tyr Thr Phe Thr Ser 
            20                  25                  30          


Tyr Asp Ile Asn Trp Val Arg Gln Ala Xaa Gly Xaa Gly Xaa Xaa Trp 
        35                  40                  45              


Xaa Gly Trp Xaa Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys 
    50                  55                  60                  


Phe Gln Gly Arg Xaa Xaa Xaa Thr Xaa Xaa Xaa Xaa Xaa Xaa Thr Xaa 
65                  70                  75                  80  


Tyr Xaa Xaa Leu Xaa Xaa Leu Arg Xaa Xaa Asp Thr Ala Xaa Tyr Tyr 
                85                  90                  95      


Cys Xaa Xaa Glu Xaa Pro Xaa Xaa Ala Xaa Phe Xaa Tyr Trp Gly Xaa 
            100                 105                 110         


Gly Thr Xaa Val Thr Val Ser Ser 
        115                 120 


<210>  138
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence of C320 and derivatives


<220>
<221>  X
<222>  (1)..(1)
<223>  X=Q or S or D or E

<220>
<221>  X
<222>  (2)..(2)
<223>  X=S or I or Y or P or L

<220>
<221>  X
<222>  (3)..(3)
<223>  X=V or A or G

<220>
<221>  X
<222>  (7)..(7)
<223>  X=P or S

<220>
<221>  X
<222>  (8)..(8)
<223>  X=P or S or A

<220>
<221>  X
<222>  (9)..(9)
<223>  X=absent or G

<220>
<221>  X
<222>  (10)..(10)
<223>  X=S or T

<220>
<221>  X
<222>  (11)..(11)
<223>  X=V or Q or L

<220>
<221>  X
<222>  (13)..(13)
<223>  X=G or V or K or A or L

<220>
<221>  X
<222>  (14)..(14)
<223>  X=A or G or T or S

<220>
<221>  X
<222>  (15)..(15)
<223>  X=P or L or A

<220>
<221>  X
<222>  (16)..(16)
<223>  X=G or R

<220>
<221>  X
<222>  (17)..(17)
<223>  X=Q or K or E

<220>
<221>  X
<222>  (18)..(18)
<223>  X=R or S or K or T

<220>
<221>  X
<222>  (19)..(19)
<223>  X=V or I or A

<220>
<221>  X
<222>  (20)..(20)
<223>  X=T or R

<220>
<221>  X
<222>  (21)..(21)
<223>  X=I or S

<220>
<221>  X
<222>  (22)..(22)
<223>  X=S

<220>
<221>  X
<222>  (24)..(24)
<223>  X=A or T

<220>
<221>  X
<222>  (25)..(25)
<223>  X=G or S

<220>
<221>  X
<222>  (39)..(39)
<223>  X=Y or L

<220>
<221>  X
<222>  (42)..(42)
<223>  X=L or K or R or H

<220>
<221>  X
<222>  (43)..(43)
<223>  X=P or Q

<220>
<221>  X
<222>  (45)..(45)
<223>  X=T or Q or K or H

<220>
<221>  X
<222>  (46)..(46)
<223>  X=A or P

<220>
<221>  X
<222>  (48)..(48)
<223>  X=K or R or V

<220>
<221>  X
<222>  (50)..(50)
<223>  X=L or V or M

<220>
<221>  X
<222>  (51)..(51)
<223>  X=I or V or S

<220>
<221>  X
<222>  (52)..(52)
<223>  X=P or E or G or Y

<220>
<221>  X
<222>  (54)..(54)
<223>  X=Y

<220>
<221>  X
<222>  (55)..(55)
<223>  X=Y

<220>
<221>  X
<222>  (60)..(60)
<223>  X=G or I

<220>
<221>  X
<222>  (61)..(61)
<223>  X=V or A or S

<220>
<221>  X
<222>  (62)..(62)
<223>  X=P or E or N

<220>
<221>  X
<222>  (66)..(66)
<223>  X=S or A

<220>
<221>  X
<222>  (68)..(68)
<223>  X=S or G or N or R

<220>
<221>  X
<222>  (71)..(71)
<223>  X=G or N

<220>
<221>  X
<222>  (72)..(72)
<223>  X=T or D

<220>
<221>  X
<222>  (73)..(73)
<223>  X=S or F

<220>
<221>  X
<222>  (74)..(74)
<223>  X=A or T

<220>
<221>  X
<222>  (76)..(76)
<223>  X=L or T or G

<220>
<221>  X
<222>  (77)..(77)
<223>  X=A or T

<220>
<221>  X
<222>  (78)..(78)
<223>  X=I or G or S

<220>
<221>  X
<222>  (79)..(79)
<223>  X=T or R

<220>
<221>  X
<222>  (80)..(80)
<223>  X=G or V

<220>
<221>  X
<222>  (81)..(81)
<223>  X=L or E or Q or R

<220>
<221>  X
<222>  (82)..(82)
<223>  X=L or A or T or S or Q

<220>
<221>  X
<222>  (83)..(83)
<223>  X=P or G or A

<220>
<221>  X
<222>  (85)..(85)
<223>  X=D or L or F

<220>
<221>  X
<222>  (86)..(86)
<223>  X=E or A

<220>
<221>  X
<222>  (87)..(87)
<223>  X=G or V or N or A

<220>
<221>  X
<222>  (96)..(96)
<223>  X=G

<220>
<221>  X
<222>  (97)..(97)
<223>  X=T

<220>
<221>  X
<222>  (103)..(103)
<223>  X=G or Q or T or A

<220>
<221>  X
<222>  (107)..(107)
<223>  X=K or V

<220>
<221>  X
<222>  (108)..(108)
<223>  X=L or E

<220>
<221>  X
<222>  (109)..(109)
<223>  X=T or I

<220>
<221>  X
<222>  (110)..(110)
<223>  X=V or K

<220>
<221>  X
<222>  (111)..(111)
<223>  X=L or R

<400>  138

Xaa Xaa Xaa Leu Thr Gln Xaa Xaa Xaa Xaa Xaa Ser Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Ser Ser Ser Asp Ile Gly Ala 
            20                  25                  30          


Gly Leu Gly Val His Trp Xaa Gln Gln Xaa Xaa Gly Xaa Xaa Pro Xaa 
        35                  40                  45              


Leu Xaa Xaa Xaa Gly Xaa Xaa Asn Arg Pro Ser Xaa Xaa Xaa Asp Arg 
    50                  55                  60                  


Phe Xaa Gly Xaa Lys Ser Xaa Xaa Xaa Xaa Ser Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Glu Xaa Xaa Xaa Asp Tyr Tyr Cys Gln Ser Tyr Asp Xaa 
                85                  90                  95      


Xaa Leu Ser Ala Leu Phe Xaa Gly Gly Thr Xaa Xaa Xaa Xaa Xaa Gly 
            100                 105                 110         


<210>  139
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  LCDR1 consensus sequence of C320 and derivatives


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  X at position 1 is A or T

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  X at position 2 is G or S

<400>  139

Xaa Xaa Ser Ser Ser Asp Ile Gly Ala Gly Leu Gly Val His 
1               5                   10                  


<210>  140
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  LCDR2 consensus sequence of C320 and derivatives

<400>  140

Gly Tyr Tyr Asn Arg Pro Ser 
1               5           


<210>  141
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  LCDR3 consensus sequence of C320 and derivatives

<400>  141

Gln Ser Tyr Asp Gly Thr Leu Ser Ala Leu 
1               5                   10  


<210>  142
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  HCDR2 consensus sequence of C320 and derivatives


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X at position 2 is methionine or leucine

<400>  142

Trp Xaa Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  143
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  HCDR3 consensus sequence of C320 and derivatives


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X = A or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = G or S

<400>  143

Glu Val Pro Xaa Thr Ala Xaa Phe Glu Tyr 
1               5                   10  


<210>  144
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of HFR1 consesnys seq od C320 and der

<400>  144

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  145
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR2 consensus sequence of C320 and derivatives


<220>
<221>  X
<222>  (6)..(6)
<223>  X= T or P

<400>  145

Trp Val Arg Gln Ala Xaa Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  146
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR3 consensus sequence of C320 and derivatives


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X = R or A

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = N or D

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X = T or R

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = S or A

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X = I or T

<400>  146

Arg Val Thr Met Thr Xaa Xaa Xaa Xaa Xaa Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  147
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR4 consensus sequence of C320 and derivatives

<400>  147

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  148
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR1 consensus sequence of C320 and derivatives

<400>  148

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys 
            20          


<210>  149
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR2 consensus sequence of C320 and derivatives


<220>
<221>  X
<222>  (15)..(15)
<223>  X = Y or E or G

<400>  149

Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Xaa 
1               5                   10                  15  


<210>  150
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR3 consensus sequence of C320 and derivatives


<220>
<221>  X
<222>  (18)..(18)
<223>  X=A or T

<400>  150

Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
1               5                   10                  15      


Leu Xaa Ile Thr Gly Leu Leu Pro Glu Asp Glu Gly Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  151
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR4 consensus sequence of C320 and derivatives


<220>
<221>  X
<222>  (3)..(3)
<223>  X=Q or K

<220>
<221>  X
<222>  (3)..(3)
<223>  X=L or T

<400>  151

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
1               5                   10      


<210>  152
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH consensus sequence of C320 and derivatives


<220>
<221>  X
<222>  (41)..(41)
<223>  X=T or P

<220>
<221>  X
<222>  (51)..(51)
<223>  X=M or L

<220>
<221>  X
<222>  (102)..(102)
<223>  X=E or D

<220>
<221>  X
<222>  (103)..(103)
<223>  X=T or D

<220>
<221>  X
<222>  (105)..(105)
<223>  X=S or A

<220>
<221>  X
<222>  (107)..(107)
<223>  X=L or D or E

<400>  152

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Xaa Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Xaa Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Xaa Xaa Ala Xaa Phe Xaa Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  153
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Vl consensus sequence of C320 and derivatives


<220>
<221>  X
<222>  (23)..(23)
<223>  X=A or T

<220>
<221>  X
<222>  (76)..(76)
<223>  X=A or T

<400>  153

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Xaa Gly Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Leu Gly Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Xaa Ile Thr Gly Leu 
65                  70                  75                  80  


Leu Pro Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Thr 
                85                  90                  95      


Leu Ser Ala Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  154
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH comprising CDRs from C320 grafted onto FRs of antibody 1TZG

<400>  154

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ile Thr Ile Thr Ala Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Asp Thr Ala Ser Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  155
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH comprising CDRs from C320 grafted onto FRs of antibody 1RHH

<400>  155

Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
1               5                   10                  15      


Ser Ser Val Gln Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
            20                  25                  30          


Tyr Asp Ile Asn Trp Val Arg Gln Ala Pro Gly His Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys 
    50                  55                  60                  


Phe Gln Gly Arg Val Thr Phe Thr Ala Asp Gln Ala Thr Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Thr Asn Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Val Pro Asp Thr Ala Ser Phe Glu Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  156
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH comprising CDRs from C320 grafted onto FRs of antibody 2DD8

<400>  156

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Thr Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Asp Thr Ala Ser Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  157
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH comprising CDRs from C320 grafted onto FRs of antibody 2JB5

<400>  157

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Asp Thr Ala Ser Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  158
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH comprising CDRs from C320 grafted onto FRs of antibody 3FKU

<400>  158

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Thr Ser Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Gln Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Asp Thr Ala Ser Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  159
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH comprising CDRs from C320 grafted onto FRs of antibody 3GBM

<400>  159

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Asp Phe Ala Gly Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Val Pro Asp Thr Ala Ser Phe Glu Tyr Trp Gly Lys Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  160
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH comprising CDRs from C320 grafted onto FRs of antibody 3LMJ

<400>  160

Gln Val Gln Val Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Lys Arg Val Ser Met Thr Glu Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Glu Val Pro Asp Thr Ala Ser Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  161
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH comprising CDRs from C320 grafted onto FRs of antibody 3P30

<400>  161

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Ala Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Gln Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Tyr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Val Pro Asp Thr Ala Ser Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  162
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VH consensus sequence of C320 and 
       derivatives


<220>
<221>  X
<222>  (1)..(1)
<223>  X=Q or E

<220>
<221>  X
<222>  (4)..(4)
<223>  X=L or V

<220>
<221>  X
<222>  (5)..(5)
<223>  X=V or L or Q

<220>
<221>  X
<222>  (6)..(6)
<223>  X=L or absent

<220>
<221>  X
<222>  (7)..(7)
<223>  X=Q or E

<220>
<221>  X
<222>  (13)..(13)
<223>  X=K or R

<220>
<221>  X
<222>  (14)..(14)
<223>  X=K or R or A

<220>
<221>  X
<222>  (17)..(17)
<223>  X=A or S

<220>
<221>  X
<222>  (20)..(20)
<223>  X=K or T or Q or R

<220>
<221>  X
<222>  (24)..(24)
<223>  X=K or T

<220>
<221>  X
<222>  (25)..(25)
<223>  X=A or S or V

<220>
<221>  X
<222>  (42)..(42)
<223>  X=T or P

<220>
<221>  X
<222>  (44)..(44)
<223>  X=Q or R or H or K

<220>
<221>  X
<222>  (46)..(46)
<223>  X=L or P

<220>
<221>  X
<222>  (47)..(47)
<223>  X=E or Q

<220>
<221>  X
<222>  (49)..(49)
<223>  X=M or L

<220>
<221>  X
<222>  (69)..(69)
<223>  X=V or I or L

<220>
<221>  X
<222>  (70)..(70)
<223>  X=T or S

<220>
<221>  X
<222>  (71)..(71)
<223>  X=M or I or F

<220>
<221>  X
<222>  (73)..(73)
<223>  X=R or A or T or E

<220>
<221>  X
<222>  (74)..(74)
<223>  X=N or D

<220>
<221>  X
<222>  (75)..(75)
<223>  X=T or R or Q or E or D

<220>
<221>  X
<222>  (76)..(76)
<223>  X=S or A or F

<220>
<221>  X
<222>  (77)..(77)
<223>  X=I or T or A

<220>
<221>  X
<222>  (78)..(78)
<223>  X=S or R or G or N

<220>
<221>  X
<222>  (80)..(80)
<223>  X=A or V

<220>
<221>  X
<222>  (82)..(82)
<223>  X=M or L

<220>
<221>  X
<222>  (83)..(83)
<223>  X=E or D

<220>
<221>  X
<222>  (85)..(85)
<223>  X=S or N or T or R

<220>
<221>  X
<222>  (86)..(86)
<223>  X=S or N

<220>
<221>  X
<222>  (89)..(89)
<223>  X=S or P or Y

<220>
<221>  X
<222>  (90)..(90)
<223>  X=E or D

<220>
<221>  X
<222>  (94)..(94)
<223>  X=V or M

<220>
<221>  X
<222>  (98)..(98)
<223>  X=A or T

<220>
<221>  X
<222>  (99)..(99)
<223>  X=R or K or T

<220>
<221>  X
<222>  (112)..(112)
<223>  X=Q or K

<220>
<221>  X
<222>  (115)..(115)
<223>  X=L or T

<400>  162

Xaa Val Gln Xaa Xaa Xaa Xaa Ser Gly Ala Glu Val Xaa Xaa Pro Gly 
1               5                   10                  15      


Xaa Ser Val Xaa Val Ser Cys Xaa Xaa Ser Gly Tyr Thr Phe Thr Ser 
            20                  25                  30          


Tyr Asp Ile Asn Trp Val Arg Gln Ala Xaa Gly Xaa Gly Xaa Xaa Trp 
        35                  40                  45              


Xaa Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys 
    50                  55                  60                  


Phe Gln Gly Arg Xaa Xaa Xaa Thr Xaa Xaa Xaa Xaa Xaa Xaa Thr Xaa 
65                  70                  75                  80  


Tyr Xaa Xaa Leu Xaa Xaa Leu Arg Xaa Xaa Asp Thr Ala Xaa Tyr Tyr 
                85                  90                  95      


Cys Xaa Xaa Glu Val Pro Asp Thr Ala Ser Phe Glu Tyr Trp Gly Xaa 
            100                 105                 110         


Gly Thr Xaa Val Thr Val Ser Ser 
        115                 120 


<210>  163
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL comprising CDRs from C320 grafted onto FRs of antibody 1RHH

<400>  163

Glu Leu Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Ala Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ala Gly Ser Ser Ser Asp Ile Gly Ala 
            20                  25                  30          


Gly Leu Gly Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Gly Tyr Tyr Asn Arg Pro Ser Gly Ile Pro Asp Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Gly Arg 
65                  70                  75                  80  


Leu Glu Pro Glu Asp Leu Ala Val Tyr Tyr Cys Gln Ser Tyr Asp Gly 
                85                  90                  95      


Thr Leu Ser Ala Leu Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  164
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL comprising CDRs from C320 grafted onto FRs of antibody 1TZGL

<400>  164

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Gln Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ala Gly Ser Ser Ser Asp Ile Gly Ala 
            20                  25                  30          


Gly Leu Gly Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Gly Tyr Tyr Asn Arg Pro Ser Gly Val Ala Asp Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg 
65                  70                  75                  80  


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Ser Tyr Asp Gly 
                85                  90                  95      


Thr Leu Ser Ala Leu Phe Gly Gln Gly Thr Lys Val Glu Val Lys Arg 
            100                 105                 110         


<210>  165
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL comprising CDRs from C320 grafted onto FRs of antibody 2DD8

<400>  165

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ala Gly Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Leu Gly Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu 
        35                  40                  45              


Val Val Tyr Gly Tyr Tyr Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe 
    50                  55                  60                  


Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val 
65                  70                  75                  80  


Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Thr 
                85                  90                  95      


Leu Ser Ala Leu Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110     


<210>  166
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL comprising CDRs from C320 grafted onto FRs of antibody 2JB5

<400>  166

Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ala Gly Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Leu Gly Val His Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Tyr Tyr Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Thr 
                85                  90                  95      


Leu Ser Ala Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  167
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL comprising CDRs from C320 grafted onto FRs of antibody 3FKU

<400>  167

Gln Pro Gly Leu Thr Gln Pro Pro Ser Val Ser Lys Gly Leu Arg Gln 
1               5                   10                  15      


Thr Ala Thr Leu Thr Cys Ala Gly Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Leu Gly Val His Trp Leu Gln Gln His Gln Gly His Pro Pro Lys Leu 
        35                  40                  45              


Leu Ser Tyr Gly Tyr Tyr Asn Arg Pro Ser Gly Ile Ser Glu Arg Phe 
    50                  55                  60                  


Ser Ala Ser Arg Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Thr 
                85                  90                  95      


Leu Ser Ala Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  168
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL comprising CDRs from C320 grafted onto FRs of antibody 3GBM

<400>  168

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ala Gly Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Leu Gly Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Tyr Tyr Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Thr Gly Asp Glu Ala Asn Tyr Tyr Cys Gln Ser Tyr Asp Gly Thr 
                85                  90                  95      


Leu Ser Ala Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  169
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL comprising CDRs from C320 grafted onto FRs of antibody 3LMJ

<400>  169

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ala Gly Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Leu Gly Val His Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Phe Gly Tyr Tyr Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Thr 
                85                  90                  95      


Leu Ser Ala Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  170
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL comprising CDRs from C320 grafted onto FRs of antibody 3P30

<400>  170

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ala Gly Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Leu Gly Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Thr 
                85                  90                  95      


Leu Ser Ala Leu Phe Gly Ala Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  171
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL comprising CDRs from C320 grafted onto FRs of antibody 3IYW

<400>  171

Gln Ser Val Leu Thr Gln Pro Ser Ser Val Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ala Gly Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Leu Gly Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Thr 
                85                  90                  95      


Leu Ser Ala Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  172
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL consensus sequence of C320 and derivatives


<220>
<221>  X
<222>  (1)..(1)
<223>  X=Q or E or S or D

<220>
<221>  X
<222>  (2)..(2)
<223>  X=S or L or I or Y

<220>
<221>  X
<222>  (3)..(3)
<223>  X=V or E or A or G

<220>
<221>  X
<222>  (7)..(7)
<223>  X=P or S

<220>
<221>  X
<222>  (8)..(8)
<223>  X=P or A or S

<220>
<221>  X
<222>  (9)..(9)
<223>  X=G or absent

<220>
<221>  X
<222>  (10)..(10)
<223>  X=S or T

<220>
<221>  X
<222>  (11)..(11)
<223>  X=V or L or Q

<220>
<221>  X
<222>  (13)..(13)
<223>  X=G or L or V or K or A

<220>
<221>  X
<222>  (14)..(14)
<223>  X=A or S or G or T

<220>
<221>  X
<222>  (15)..(15)
<223>  X=P or A or L

<220>
<221>  X
<222>  (16)..(16)
<223>  X=G or R

<220>
<221>  X
<222>  (17)..(17)
<223>  X=Q or E or K

<220>
<221>  X
<222>  (18)..(18)
<223>  X=R or T or S or K

<220>
<221>  X
<222>  (19)..(19)
<223>  X=V or A or I

<220>
<221>  X
<222>  (20)..(20)
<223>  X=T or R

<220>
<221>  X
<222>  (21)..(21)
<223>  X=I or L

<220>
<221>  X
<222>  (22)..(22)
<223>  X=S or T

<220>
<221>  X
<222>  (39)..(39)
<223>  X=Y or L

<220>
<221>  X
<222>  (42)..(42)
<223>  X=L or K or R or H

<220>
<221>  X
<222>  (43)..(43)
<223>  X=P or Q

<220>
<221>  X
<222>  (45)..(45)
<223>  X=T or Q or K or H

<220>
<221>  X
<222>  (46)..(46)
<223>  X=A or P

<220>
<221>  X
<222>  (48)..(48)
<223>  X=K or R or V

<220>
<221>  X
<222>  (50)..(50)
<223>  X=L or V or M

<220>
<221>  X
<222>  (51)..(51)
<223>  X=I or V or S

<220>
<221>  X
<222>  (60)..(60)
<223>  X=G or I

<220>
<221>  X
<222>  (61)..(61)
<223>  X=V or A or S

<220>
<221>  X
<222>  (62)..(62)
<223>  X=P or E or N

<220>
<221>  X
<222>  (66)..(66)
<223>  X=S or A

<220>
<221>  X
<222>  (68)..(68)
<223>  X=S or G or N or R

<220>
<221>  X
<222>  (71)..(71)
<223>  X=G or N

<220>
<221>  X
<222>  (72)..(72)
<223>  X=T or D

<220>
<221>  X
<222>  (73)..(73)
<223>  X=S or F

<220>
<221>  X
<222>  (74)..(74)
<223>  X=A or T

<220>
<221>  X
<222>  (76)..(76)
<223>  X=L or T or G

<220>
<221>  X
<222>  (78)..(78)
<223>  X=I or G or S

<220>
<221>  X
<222>  (79)..(79)
<223>  X=T or R

<220>
<221>  X
<222>  (80)..(80)
<223>  X=G or V

<220>
<221>  X
<222>  (81)..(81)
<223>  X=L or E or Q or R

<220>
<221>  X
<222>  (82)..(82)
<223>  X=L or A or T or S

<220>
<221>  X
<222>  (83)..(83)
<223>  X=P or G

<220>
<221>  X
<222>  (85)..(85)
<223>  X=D or L or F

<220>
<221>  X
<222>  (86)..(86)
<223>  X=E or A

<220>
<221>  X
<222>  (87)..(87)
<223>  X=G or V or N

<220>
<221>  X
<222>  (103)..(103)
<223>  X=G or Q or T or A

<220>
<221>  X
<222>  (107)..(107)
<223>  X=K or V

<220>
<221>  X
<222>  (108)..(108)
<223>  X=L or E

<220>
<221>  X
<222>  (109)..(109)
<223>  X=T or I

<220>
<221>  X
<222>  (110)..(110)
<223>  X=V or K

<220>
<221>  X
<222>  (111)..(111)
<223>  X=L or R

<400>  172

Xaa Xaa Xaa Leu Thr Gln Xaa Xaa Xaa Xaa Xaa Ser Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Cys Ala Gly Ser Ser Ser Asp Ile Gly Ala 
            20                  25                  30          


Gly Leu Gly Val His Trp Xaa Gln Gln Xaa Xaa Gly Xaa Xaa Pro Xaa 
        35                  40                  45              


Leu Xaa Xaa Tyr Gly Tyr Tyr Asn Arg Pro Ser Xaa Xaa Pro Asp Arg 
    50                  55                  60                  


Phe Xaa Gly Xaa Lys Ser Xaa Xaa Xaa Xaa Ser Xaa Ala Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Glu Xaa Xaa Xaa Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly 
                85                  90                  95      


Thr Leu Ser Ala Leu Phe Xaa Gly Gly Thr Xaa Xaa Xaa Xaa Xaa Gly 
            100                 105                 110         


<210>  173
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH consensus sequence of C320 and derivatives


<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  X= T or P

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  X= M or L

<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  X= R or A

<220>
<221>  MISC_FEATURE
<222>  (73)..(73)
<223>  X= N or D

<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  X= T or R

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  X= S or A

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  X=I or T

<220>
<221>  MISC_FEATURE
<222>  (102)..(102)
<223>  X= D or E

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  X= S or A

<400>  173

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Xaa Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Xaa Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Xaa Xaa Xaa Xaa Xaa Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Xaa Thr Ala Xaa Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  174
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL consensus sequence of C320 and derivatives


<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  X = A or T

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  X = G or S

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  X = Y or P or E or G

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  X = A or T

<400>  174

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Xaa Xaa Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Leu Gly Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Xaa Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Xaa Ile Thr Gly Leu 
65                  70                  75                  80  


Leu Pro Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Thr 
                85                  90                  95      


Leu Ser Ala Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  175
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VH of antibody C320-162

<400>  175

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ala Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Glu Thr Ala Ser Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  176
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VH of antibody C320-163

<400>  176

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Asp Thr Ala Ser Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  177
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VH of antibody C320-164

<400>  177

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Glu Thr Ala Ser Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  178
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VH of antibody C320-165

<400>  178

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Glu Thr Ala Ser Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  179
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VH of antibody C320-166

<400>  179

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Glu Thr Ala Ser Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  180
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VH of antibody C320-167

<400>  180

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Glu Thr Ala Ser Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  181
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VH of antibody C320-168

<400>  181

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Glu Thr Ala Ala Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  182
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VH of antibody C320-169

<400>  182

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Glu Thr Ala Ala Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  183
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VH of antibody C320-170

<400>  183

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Asp Thr Ala Ser Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  184
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VH of antibody C320-171

<400>  184

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Asp Thr Ala Ser Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  185
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VH of antibody C320-172

<400>  185

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Asp Thr Ala Ser Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  186
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VH of antibody C320-179

<400>  186

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Glu Thr Ala Ala Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  187
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VH of antibody C320-183

<400>  187

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Glu Thr Ala Ala Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  188
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VL of antibody C320-162

<400>  188

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ala Gly Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Leu Gly Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Thr Ile Thr Gly Leu 
65                  70                  75                  80  


Leu Pro Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Thr 
                85                  90                  95      


Leu Ser Ala Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  189
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VL of antibody C320-163

<400>  189

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ala Gly Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Leu Gly Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Thr Ile Thr Gly Leu 
65                  70                  75                  80  


Leu Pro Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Thr 
                85                  90                  95      


Leu Ser Ala Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  190
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VL of antibody C320-164

<400>  190

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ala Ser Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Leu Gly Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Thr Ile Thr Gly Leu 
65                  70                  75                  80  


Leu Pro Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Thr 
                85                  90                  95      


Leu Ser Ala Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  191
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VL of antibody C320-165

<400>  191

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Ser Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Leu Gly Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Thr Ile Thr Gly Leu 
65                  70                  75                  80  


Leu Pro Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Thr 
                85                  90                  95      


Leu Ser Ala Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  192
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VL of antibody C320-166

<400>  192

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Leu Gly Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Thr Ile Thr Gly Leu 
65                  70                  75                  80  


Leu Pro Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Thr 
                85                  90                  95      


Leu Ser Ala Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  193
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VL of antibody C320-167

<400>  193

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ala Gly Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Leu Gly Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Thr Ile Thr Gly Leu 
65                  70                  75                  80  


Leu Pro Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Thr 
                85                  90                  95      


Leu Ser Ala Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  194
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VL of antibody C320-168

<400>  194

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Ser Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Leu Gly Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Thr Ile Thr Gly Leu 
65                  70                  75                  80  


Leu Pro Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Thr 
                85                  90                  95      


Leu Ser Ala Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  195
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VL of antibody C320-169

<400>  195

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ala Gly Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Leu Gly Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Thr Ile Thr Gly Leu 
65                  70                  75                  80  


Leu Pro Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Thr 
                85                  90                  95      


Leu Ser Ala Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  196
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VL of antibody C320-170

<400>  196

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Ser Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Leu Gly Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Thr Ile Thr Gly Leu 
65                  70                  75                  80  


Leu Pro Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Thr 
                85                  90                  95      


Leu Ser Ala Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  197
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VL of antibody C320-171

<400>  197

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Ser Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Leu Gly Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Pro Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Thr Ile Thr Gly Leu 
65                  70                  75                  80  


Leu Pro Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Thr 
                85                  90                  95      


Leu Ser Ala Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  198
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VL of antibody C320-172

<400>  198

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Ser Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Leu Gly Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Glu Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Thr Ile Thr Gly Leu 
65                  70                  75                  80  


Leu Pro Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Thr 
                85                  90                  95      


Leu Ser Ala Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  199
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VL of antibody C320-179

<400>  199

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Ser Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Leu Gly Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Glu Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Thr Ile Thr Gly Leu 
65                  70                  75                  80  


Leu Pro Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Thr 
                85                  90                  95      


Leu Ser Ala Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  200
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VL of antibody C320-183

<400>  200

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Ser Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Leu Gly Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Gly Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Thr Ile Thr Gly Leu 
65                  70                  75                  80  


Leu Pro Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Thr 
                85                  90                  95      


Leu Ser Ala Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  201
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VL of germline sequence IGLV1-40*1


<220>
<221>  misc_feature
<222>  (100)..(111)
<223>  Xaa can be any naturally occurring amino acid

<400>  201

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110     


<210>  202
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of soluble hTL1a

<400>  202

Leu Lys Gly Gln Glu Phe Ala Pro Ser His Gln Gln Val Tyr Ala Pro 
1               5                   10                  15      


Leu Arg Ala Asp Gly Asp Lys Pro Arg Ala His Leu Thr Val Val Arg 
            20                  25                  30          


Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His Trp 
        35                  40                  45              


Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr 
    50                  55                  60                  


Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser 
65                  70                  75                  80  


Gln Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln 
                85                  90                  95      


Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys 
            100                 105                 110         


Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys 
        115                 120                 125             


Ser Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly 
    130                 135                 140                 


Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser 
145                 150                 155                 160 


Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly 
                165                 170                 175     


Ala Phe Leu Leu 
            180 


<210>  203
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of N-linked glycosylation site in VH of C320

<400>  203

Arg Asn Thr Ser Ile 
1               5   


<210>  204
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence from VH of 1TZG corresponding to N-linked 
       glycosylation site in VH of C320

<400>  204

Ala Asp Arg Ser Thr 
1               5   


<210>  205
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of peptide from VH of C320-168

<400>  205

Gly Leu Glu Trp Met Gly Trp Leu Asn Pro Asn Ser Gly Asn Thr 
1               5                   10                  15  


<210>  206
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of peptide from VL of C320-168

<400>  206

Leu Leu Ile Tyr Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp 
1               5                   10                  15  


<210>  207
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of influenza peptide

<400>  207

Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr 
1               5                   10              


<210>  208
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of mutant peptide from VL of C320-168

<400>  208

Leu Leu Ile Glu Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp 
1               5                   10                  15  


<210>  209
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of mutant peptide from VL of C320-168

<400>  209

Leu Leu Ile Gly Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp 
1               5                   10                  15  


<210>  210
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of mutant peptide from VL of C320-168

<400>  210

Leu Leu Ile Pro Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp 
1               5                   10                  15  


<210>  211
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of mutant peptide from VL of C320-168

<400>  211

Leu Leu Ile Lys Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp 
1               5                   10                  15  


<210>  212
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of mutant peptide from VL of C320-168

<400>  212

Leu Leu Ile Tyr Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp 
1               5                   10                  15  


<210>  213
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of mutant peptide from VL of C320-168

<400>  213

Leu Leu Ile Glu Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp 
1               5                   10                  15  


<210>  214
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of mutant peptide from VL of C320-168

<400>  214

Leu Leu Ile Gly Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp 
1               5                   10                  15  


<210>  215
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of mutant peptide from VL of C320-168

<400>  215

Leu Leu Ile Pro Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp 
1               5                   10                  15  


<210>  216
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of mutant peptide from VL of C320-168

<400>  216

Leu Leu Ile Lys Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp 
1               5                   10                  15  


<210>  217
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of mutant peptide from VL of C320-168

<400>  217

Leu Leu Ile Tyr Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp 
1               5                   10                  15  


<210>  218
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of mutant peptide from VL of C320-168

<400>  218

Leu Leu Ile Glu Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp 
1               5                   10                  15  


<210>  219
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of mutant peptide from VL of C320-168

<400>  219

Leu Leu Ile Gly Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp 
1               5                   10                  15  


<210>  220
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of mutant peptide from VL of C320-168

<400>  220

Leu Leu Ile Pro Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp 
1               5                   10                  15  


<210>  221
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of mutant peptide from VL of C320-168

<400>  221

Leu Leu Ile Lys Gly Tyr Tyr Asn Arg Pro Ser Gly Val Pro Asp 
1               5                   10                  15  


<210>  222
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding VH of antibody C320-162

<400>  222
caggtgcagc tggtgcagtc tggggccgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc agttatgata tcaactgggt gcgacaggcc      120

cccggacaag ggcttgagtg gatgggatgg ctgaacccta acagtggtaa cacaggctat      180

gcacagaagt tccagggcag agtcaccatg accaggaaca ccgccataag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagaagtg      300

cctgagacgg cctcctttga gtactggggc cagggaaccc tggtgacagt gtcctca         357


<210>  223
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding VH of antibody C320-163

<400>  223
caggtgcagc tggtgcagtc tggggcggag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc agttatgata tcaactgggt gcgacaggcc      120

cccggacaag ggcttgagtg gatgggatgg atgaacccta acagtggtaa cacaggctat      180

gcacagaagt tccagggcag agtcaccatg accgcagatc gttccaccag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagaagtg      300

cctgatacgg cctcctttga gtactggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  224
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding VH of antibodies C320-164, C320-165,
       C320-166 and C320-167

<400>  224
caggtgcagc tggtgcagtc tggggccgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc agttatgata tcaactgggt gcgacaggcc      120

cccggacaag ggcttgagtg gatgggatgg ctgaacccta acagtggtaa cacaggctat      180

gcacagaagt tccagggcag agtcaccatg accaggaaca cctccataag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagaagtg      300

cctgagacgg cctcctttga gtactggggc cagggaaccc tggtgacagt gtcctca         357


<210>  225
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding VH of antibodies C320-168 and 
       C320-169

<400>  225
caggtgcagc tggtgcagtc tggggccgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc agttatgata tcaactgggt gcgacaggcc      120

cccggacaag ggcttgagtg gatgggatgg ctgaacccta acagtggtaa cacaggctat      180

gcacagaagt tccagggcag agtcaccatg accaggaaca cctccataag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagaagtg      300

cctgagacgg ccgcctttga gtactggggc cagggaaccc tggtgacagt gtcctca         357


<210>  226
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding VH of antibodies C320-170 and 
       C320-172

<400>  226
caggtgcagc tggtgcagtc tggggcggag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc agttatgata tcaactgggt gcgacaggcc      120

cccggacaag ggcttgagtg gatgggatgg atgaacccta acagtggtaa cacaggctat      180

gcacagaagt tccagggcag agtcaccatg accgcagatc gttccaccag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagaagtg      300

cctgatacgg cctcctttga gtactggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  227
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding VH of antibodies C320-179 and 
       C320-183

<400>  227
caggtgcagc tggtgcagtc tggggcggag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc agttatgata tcaactgggt gcgacaggcc      120

cccggacaag ggcttgagtg gatgggatgg ctgaacccta acagtggtaa cacaggctat      180

gcacagaagt tccagggcag agtcaccatg accgcagatc gttccaccag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagaagtg      300

cctgagacgg ccgcctttga gtactggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  228
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding VL of antibodies C320-162, C320-163,
       C320-167 and C320-169

<400>  228
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcgctg ggagtagttc cgacatcggg gcaggtcttg gcgtgcactg gtatcagcag      120

cttccaggaa cagcccccaa actcctcatc tatggttact acaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctgaccat cactgggctc      240

ctgcctgagg atgagggtga ttattactgc cagtcctatg acggcactct gagtgcccta      300

ttcggcggag ggaccaagct gaccgtccta ggt                                   333


<210>  229
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding VL of antibody C320-164

<400>  229
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcgcta gcagtagttc cgacatcggg gcaggtcttg gcgtgcactg gtatcagcag      120

cttccaggaa cagcccccaa actcctcatc tatggttact acaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctgaccat cactgggctc      240

ctgcctgagg atgagggtga ttattactgc cagtcctatg acggcactct gagtgcccta      300

ttcggcggag ggaccaagct gaccgtccta ggt                                   333


<210>  230
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding VL of antibodies C320-165, C320-168 
       and C320-170

<400>  230
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcacta gcagtagttc cgacatcggg gcaggtcttg gcgtgcactg gtatcagcag      120

cttccaggaa cagcccccaa actcctcatc tatggttact acaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctgaccat cactgggctc      240

ctgcctgagg atgagggtga ttattactgc cagtcctatg acggcactct gagtgcccta      300

ttcggcggag ggaccaagct gaccgtccta ggt                                   333


<210>  231
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding VL of antibody C320-166

<400>  231
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagtagttc cgacatcggg gcaggtcttg gcgtgcactg gtatcagcag      120

cttccaggaa cagcccccaa actcctcatc tatggttact acaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctgaccat cactgggctc      240

ctgcctgagg atgagggtga ttattactgc cagtcctatg acggcactct gagtgcccta      300

ttcggcggag ggaccaagct gaccgtccta ggt                                   333


<210>  232
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding VL of antibodies C320-172 and 
       C320-179

<400>  232
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcacta gcagtagttc cgacatcggg gcaggtcttg gcgtgcactg gtatcagcag      120

cttccaggaa cagcccccaa actcctcatc gaaggttact acaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctgaccat cactgggctc      240

ctgcctgagg atgagggtga ttattactgc cagtcctatg acggcactct gagtgcccta      300

ttcggcggag ggaccaagct gaccgtccta ggt                                   333


<210>  233
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding VL of antibody C320-183

<400>  233
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcacta gcagtagttc cgacatcggg gcaggtcttg gcgtgcactg gtatcagcag      120

cttccaggaa cagcccccaa actcctcatc ggaggttact acaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctgaccat cactgggctc      240

ctgcctgagg atgagggtga ttattactgc cagtcctatg acggcactct gagtgcccta      300

ttcggcggag ggaccaagct gaccgtccta ggt                                   333


<210>  234
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of VH of antibody C320-12 and C320-22

<400>  234

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Thr Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Pro Asp Thr Ala Ser Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  235
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  consensus of HCDR3 of C320 and derivatives


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X = V or A or S or H or D or L or Y or P or Q or K

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X = A or S or H or K or E or D

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X = A or S or D or Y or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = A or S or H or L or D or Y

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = A or S or H or L or D or P or Q or E or K

<400>  235

Glu Xaa Pro Xaa Xaa Ala Xaa Phe Xaa Tyr 
1               5                   10  


