                         SEQUENCE LISTING

<110>  University of North Carolina at Chapel Hill
       Tarran, Robert
       Stutts, Monroe
       Donaldson, Scott
 
<120>  REGULATION OF SODIUM CHANNELS BY PLUNC PROTEINS

<130>  5470-527WO2

<150>  US 61/536,647
<151>  2011-09-20

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Phe Gln Thr Gly Gly Leu Ile Val Phe Tyr Gly Leu Leu Ala Gln 
1               5                   10                  15      


Thr Met Ala Gln Phe Gly Gly Leu Pro Val Pro Leu Asp Gln Thr Leu 
            20                  25                  30          


Pro Leu Asn Val Asn Pro Ala Leu Pro Leu Ser Pro Thr Gly Leu Ala 
        35                  40                  45              


Gly Ser Leu Thr Asn Ala Leu Ser Asn Gly Leu Leu Ser Gly Gly Leu 
    50                  55                  60                  


Leu Gly Ile Leu Glu Asn Leu Pro Leu Leu Asp Ile Leu Lys Pro Gly 
65                  70                  75                  80  


Gly Gly Thr Ser Gly Gly Leu Leu Gly Gly Leu Leu Gly Lys Val Thr 
                85                  90                  95      


Ser Val Ile Pro Gly Leu Asn Asn Ile Ile Asp Ile Lys Val Thr Asp 
            100                 105                 110         


Pro Gln Leu Leu Glu Leu Gly Leu Val Gln Ser Pro Asp Gly His Arg 
        115                 120                 125             


Leu Tyr Val Thr Ile Pro Leu Gly Ile Lys Leu Gln Val Asn Thr Pro 
    130                 135                 140                 


Leu Val Gly Ala Ser Leu Leu Arg Leu Ala Val Lys Leu Asp Ile Thr 
145                 150                 155                 160 


Ala Glu Ile Leu Ala Val Arg Asp Lys Gln Glu Arg Ile His Leu Val 
                165                 170                 175     


Leu Gly Asp Cys Thr His Ser Pro Gly Ser Leu Gln Ile Ser Leu Leu 
            180                 185                 190         


Asp Gly Leu Gly Pro Leu Pro Ile Gln Gly Leu Leu Asp Ser Leu Thr 
        195                 200                 205             


Gly Ile Leu Asn Lys Val Leu Pro Glu Leu Val Gln Gly Asn Val Cys 
    210                 215                 220                 


Pro Leu Val Asn Glu Val Leu Arg Gly Leu Asp Ile Thr Leu Val His 
225                 230                 235                 240 


Asp Ile Val Asn Met Leu Ile His Gly Leu Gln Phe Val Ile Lys Val 
                245                 250                 255     


<210>  2
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Gln Leu Trp Lys Leu Val Leu Leu Cys Gly Val Leu Thr Gly 
1               5                   10                  15      


Thr Ser Glu Ser Leu Leu Asp Asn Leu Gly Asn Asp Leu Ser Asn Val 
            20                  25                  30          


Val Asp Lys Leu Glu Pro Val Leu His Glu Gly Leu Glu Thr Val Asp 
        35                  40                  45              


Asn Thr Leu Lys Gly Ile Leu Glu Lys Leu Lys Val Asp Leu Gly Val 
    50                  55                  60                  


Leu Gln Lys Ser Ser Ala Trp Gln Leu Ala Lys Gln Lys Ala Gln Glu 
65                  70                  75                  80  


Ala Glu Lys Leu Leu Asn Asn Val Ile Ser Lys Leu Leu Pro Thr Asn 
                85                  90                  95      


Thr Asp Ile Phe Gly Leu Lys Ile Ser Asn Ser Leu Ile Leu Asp Val 
            100                 105                 110         


Lys Ala Glu Pro Ile Asp Asp Gly Lys Gly Leu Asn Leu Ser Phe Pro 
        115                 120                 125             


Val Thr Ala Asn Val Thr Val Ala Gly Pro Ile Ile Gly Gln Ile Ile 
    130                 135                 140                 


Asn Leu Lys Ala Ser Leu Asp Leu Leu Thr Ala Val Thr Ile Glu Thr 
145                 150                 155                 160 


Asp Pro Gln Thr His Gln Pro Val Ala Val Leu Gly Glu Cys Ala Ser 
                165                 170                 175     


Asp Pro Thr Ser Ile Ser Leu Ser Leu Leu Asp Lys His Ser Gln Ile 
            180                 185                 190         


Ile Asn Lys Phe Val Asn Ser Val Ile Asn Thr Leu Lys Ser Thr Val 
        195                 200                 205             


Ser Ser Leu Leu Gln Lys Glu Ile Cys Pro Leu Ile Arg Ile Phe Ile 
    210                 215                 220                 


His Ser Leu Asp Val Asn Val Ile Gln Gln Val Val Asp Asn Pro Gln 
225                 230                 235                 240 


His Lys Thr Gln Leu Gln Thr Leu Ile 
                245                 


<210>  3
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  3
ctgatggcca ccgtcctat                                                    19


<210>  4
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  4
aggtggatcc tctcctgctt                                                   20


<210>  5
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  Anti-SPLUNC1 shRNA sequence

<400>  5
auaaaguccu gccugaguuu u                                                 21


<210>  6
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  Anti-SPLUNC1 shRNA sequence

<400>  6
aacucaggca ggacuuuauu u                                                 21


<210>  7
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  Anti-SPLUNC1 shRNA sequence

<400>  7
gcaggaagcu ugacaaaugu u                                                 21


<210>  8
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  Anti-SPLUNC1 shRNA sequence

<400>  8
cauuugucaa gcuuccugcu u                                                 21


<210>  9
<211>  19
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Amino acids 4-22 of the alpha 26 subunit of ENaC

<400>  9

Gly Ala Leu Pro His Pro Leu Gln Arg Leu Arg Thr Pro Pro Pro Pro 
1               5                   10                  15      


Asn Pro Ala 
            


<210>  10
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  Amino acids 11-24 of the gamma 43 subunit of ENaC

<400>  10

Gly Thr Pro Pro Arg Phe Leu Asn Leu Ile Pro Leu Leu Val 
1               5                   10                  


<210>  11
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  11

Gly Gly Leu Pro Val Pro Leu Asp Gln Thr Leu Pro Leu Asn Val Asn 
1               5                   10                  15      


Pro Ala 
        


<210>  12
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  12

Gly Gly Leu Pro Val Pro Leu Asp Gln Thr Leu Pro Leu Asn Val Asn 
1               5                   10                  15      


Pro Ala Leu Pro Leu Ser Pro Thr Gly Leu Ala Gly Ser Leu Thr Asn 
            20                  25                  30          


Ala Leu Ser Asn Gly Leu Leu Ser Gly Gly Leu Leu Gly Ile Leu Glu 
        35                  40                  45              


Asn Leu Pro Leu Leu Asp Ile Leu Lys Pro Gly Gly Gly Thr Ser Gly 
    50                  55                  60                  


Gly Leu Leu Gly Gly Leu Leu Gly 
65                  70          


<210>  13
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Control peptide sequence

<400>  13

Ala Asp Gly Gly Leu Leu Leu Leu Asn Asn Pro Pro Pro Pro Gln Thr 
1               5                   10                  15      


Val Val 
        


<210>  14
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  14

Leu Pro Val Pro Leu Asp Gln Thr 
1               5               


