﻿               SEQUENCE LISTING

<110> Universität Stuttgart

<120> Serum half-life extension using IgBD

<130> 762-1 PCT

<150>  US 61/538,310
<151>  2011-09-23

<150>  EP 11 007 788.0
<151>  2011-09-23

<160> 17

<170> BiSSAP 1.0

<210> 1
<211> 55
<212> PRT
<213> Streptococcus

<220> 
<221> SOURCE
<222> 1..55
<223> /mol_type="protein"
      /organism="Streptococcus"

<400> 1
Thr Tyr Lys Leu Val Ile Asn Gly Lys Thr Leu Lys Gly Glu Thr Thr 
1               5                   10                   15    
Thr Lys Ala Val Asp Ala Glu Thr Ala Glu Lys Ala Phe Lys Gln Tyr 
            20                   25                  30        
Ala Asn Asp Asn Gly Val Asp Gly Val Trp Thr Tyr Asp Asp Ala Thr 
        35                   40                  45            
Lys Thr Phe Thr Val Thr Glu 
    50                   55

<210> 2
<211> 55
<212> PRT
<213> Streptococcus

<220> 
<221> SOURCE
<222> 1..55
<223> /mol_type="protein"
      /organism="Streptococcus"

<400> 2
Thr Tyr Lys Leu Val Ile Asn Gly Lys Ala Leu Ala Gly Ala Thr Thr 
1               5                   10                   15    
Thr Lys Ala Val Asp Ala Glu Thr Ala Glu Lys Ala Phe Lys Gln Tyr 
            20                   25                  30        
Ala Asn Asp Asn Gly Val Asp Gly Val Trp Thr Tyr Asp Asp Ala Thr 
        35                   40                  45            
Lys Thr Phe Thr Val Thr Glu 
    50                   55

<210> 3
<211> 55
<212> PRT
<213> Streptococcus

<220> 
<221> SOURCE
<222> 1..55
<223> /mol_type="protein"
      /organism="Streptococcus"

<400> 3
Thr Tyr Lys Leu Val Ile Asn Gly Lys Thr Leu Lys Gly Glu Thr Thr 
1               5                   10                   15    
Thr Lys Ala Val Asp Ala Glu Thr Ala Ala Ala Ala Phe Ala Gln Tyr 
            20                   25                  30        
Ala Asn Asp Asn Gly Val Asp Gly Val Trp Thr Tyr Asp Asp Ala Thr 
        35                   40                  45            
Lys Thr Phe Thr Val Thr Glu 
    50                   55

<210> 4
<211> 330
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..330
<223> /mol_type="protein"
      /organism="Homo sapiens"

<220> 
<221> BINDING
<222> 5..10
<223> /note="SpG-C3 binding epitope"

<220> 
<221> BINDING
<222> 90..97
<223> /note="SpG-C3 binding epitope"

<400> 4
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                   15    
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                   25                  30        
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                   40                  45            
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                   55                  60                
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                   70                  75                  80
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                   90                  95    
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                  105                110        
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                  120                125            
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                  135                140                
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                  150                155                  160
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                  170                175    
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                  185                190        
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                  200                205            
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                  215                220                
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                  230                235                  240
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                  250                255    
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                  265                270        
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                  280                285            
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                  295                300                
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                  310                315                  320
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                  330

<210> 5
<211> 326
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..326
<223> /mol_type="protein"
      /organism="Homo sapiens"

<220> 
<221> BINDING
<222> 5..10
<223> /note="SpG-C3 binding epitope"

<220> 
<221> BINDING
<222> 90..97
<223> /note="SpG-C3 binding epitope"

<400> 5
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                   15    
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                   25                  30        
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                   40                  45            
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                   55                  60                
Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                   70                  75                  80
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                   90                  95    
Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                  105                110        
Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                  120                125            
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                  135                140                
Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                  150                155                  160
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                  170                175    
Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                  185                190        
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                  200                205            
Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                  215                220                
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                  230                235                  240
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                  250                255    
Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                  265                270        
Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                  280                285            
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                  295                300                
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                  310                315                  320
Ser Leu Ser Pro Gly Lys 
                325    

<210> 6
<211> 377
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..377
<223> /mol_type="protein"
      /organism="Homo sapiens"

<220> 
<221> BINDING
<222> 5..10
<223> /note="SpG-C3 binding epitope"

<220> 
<221> BINDING
<222> 90..97
<223> /note="SpG-C3 binding epitope"

<400> 6
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                   15    
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                   25                  30        
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                   40                  45            
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                   55                  60                
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                   70                  75                  80
Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                   90                  95    
Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                  105                110        
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                  120                125            
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                  135                140                
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                  150                155                  160
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                  170                175    
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                  185                190        
Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                  200                205            
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                  215                220                
Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                  230                235                  240
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                  250                255    
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                  265                270        
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                  280                285            
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                  295                300                
Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                  310                315                  320
Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                  330                335    
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                  345                350        
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                  360                365            
Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                  375        

<210> 7
<211> 327
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..327
<223> /mol_type="protein"
      /organism="Homo sapiens"

<220> 
<221> BINDING
<222> 5..10
<223> /note="SpG-C3 binding epitope"

<220> 
<221> BINDING
<222> 90..97
<223> /note="SpG-C3 binding epitope"

<400> 7
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                   15    
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                   25                  30        
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                   40                  45            
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                   55                  60                
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                   70                  75                  80
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                   90                  95    
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                  105                110        
Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                  120                125            
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                  135                140                
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                  150                155                  160
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                  170                175    
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                  185                190        
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                  200                205            
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                  215                220                
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                  230                235                  240
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                  250                255    
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                  265                270        
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                  280                285            
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                  295                300                
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                  310                315                  320
Leu Ser Leu Ser Leu Gly Lys 
                325        

<210> 8
<211> 324
<212> PRT
<213> Mus <mouse, genus>

<220> 
<221> SOURCE
<222> 1..324
<223> /mol_type="protein"
      /organism="Mus <mouse, genus>"

<220> 
<221> BINDING
<222> 5..10
<223> /note="SpG-C3 binding epitope"

<220> 
<221> BINDING
<222> 89..96
<223> /note="SpG-C3 binding epitope"

<400> 8
Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
1               5                   10                   15    
Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                   25                  30        
Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                   40                  45            
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                   55                  60                
Ser Ser Ser Val Thr Val Pro Ser Ser Pro Arg Pro Ser Glu Thr Val 
65                   70                  75                  80
Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                   90                  95    
Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
            100                  105                110        
Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
        115                  120                125            
Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 
    130                  135                140                
Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
145                  150                155                  160
Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                165                  170                175    
Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
            180                  185                190        
Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
        195                  200                205            
Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
    210                  215                220                
Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
225                  230                235                  240
Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 
                245                  250                255    
Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
            260                  265                270        
Pro Ile Met Asn Thr Asn Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
        275                  280                285            
Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
    290                  295                300                
Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
305                  310                315                  320
Ser Pro Gly Lys 
                

<210> 9
<211> 330
<212> PRT
<213> Mus <mouse, genus>

<220> 
<221> SOURCE
<222> 1..330
<223> /mol_type="protein"
      /organism="Mus <mouse, genus>"

<220> 
<221> BINDING
<222> 5..10
<223> /note="SpG-C3 binding epitope"

<220> 
<221> BINDING
<222> 89..96
<223> /note="SpG-C3 binding epitope"

<400> 9
Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly 
1               5                   10                   15    
Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                   25                  30        
Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                   40                  45            
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                   55                  60                
Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile 
65                   70                  75                  80
Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                   90                  95    
Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys 
            100                  105                110        
Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
        115                  120                125            
Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys 
    130                  135                140                
Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 
145                  150                155                  160
Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 
                165                  170                175    
Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 
            180                  185                190        
His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
        195                  200                205            
Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
    210                  215                220                
Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 
225                  230                235                  240
Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 
                245                  250                255    
Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
            260                  265                270        
Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 
        275                  280                285            
Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 
    290                  295                300                
Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 
305                  310                315                  320
Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                325                  330

<210> 10
<211> 335
<212> PRT
<213> Mus <mouse, genus>

<220> 
<221> SOURCE
<222> 1..335
<223> /mol_type="protein"
      /organism="Mus <mouse, genus>"

<220> 
<221> BINDING
<222> 4..9
<223> /note="SpG-C3 binding epitope"

<220> 
<221> BINDING
<222> 88..95
<223> /note="SpG-C3 binding epitope"

<400> 10
Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Cys Gly Asp 
1               5                   10                   15    
Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe 
            20                   25                  30        
Pro Glu Ser Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Ser 
        35                   40                  45            
Val His Thr Phe Pro Ala Leu Leu Gln Ser Gly Leu Tyr Thr Met Ser 
    50                   55                  60                
Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val Thr 
65                   70                  75                  80
Cys Ser Val Ala His Pro Ala Ser Ser Thr Thr Val Asp Lys Lys Leu 
                85                   90                  95    
Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Cys Pro Pro Cys Lys 
            100                  105                110        
Glu Cys His Lys Cys Pro Ala Pro Asn Leu Glu Gly Gly Pro Ser Val 
        115                  120                125            
Phe Ile Phe Pro Pro Asn Ile Lys Asp Val Leu Met Ile Ser Leu Thr 
    130                  135                140                
Pro Lys Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp 
145                  150                155                  160
Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln 
                165                  170                175    
Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Ile Arg Val Val Ser 
            180                  185                190        
Thr Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys 
        195                  200                205            
Cys Lys Val Asn Asn Lys Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile 
    210                  215                220                
Ser Lys Ile Lys Gly Leu Val Arg Ala Pro Gln Val Tyr Ile Leu Pro 
225                  230                235                  240
Pro Pro Ala Glu Gln Leu Ser Arg Lys Asp Val Ser Leu Thr Cys Leu 
                245                  250                255    
Val Val Gly Phe Asn Pro Gly Asp Ile Ser Val Glu Trp Thr Ser Asn 
            260                  265                270        
Gly His Thr Glu Glu Asn Tyr Lys Asp Thr Ala Pro Val Leu Asp Ser 
        275                  280                285            
Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Met Lys Thr Ser Lys 
    290                  295                300                
Trp Glu Lys Thr Asp Ser Phe Ser Cys Asn Val Arg His Glu Gly Leu 
305                  310                315                  320
Lys Asn Tyr Tyr Leu Lys Lys Thr Ile Ser Arg Ser Pro Gly Lys 
                325                  330                335

<210> 11
<211> 398
<212> PRT
<213> Mus <mouse, genus>

<220> 
<221> SOURCE
<222> 1..398
<223> /mol_type="protein"
      /organism="Mus <mouse, genus>"

<220> 
<221> BINDING
<222> 4..9
<223> /note="SpG-C3 binding epitope"

<220> 
<221> BINDING
<222> 88..95
<223> /note="SpG-C3 binding epitope"

<400> 11
Thr Thr Thr Ala Pro Ser Val Tyr Pro Leu Val Pro Gly Cys Ser Asp 
1               5                   10                   15    
Thr Ser Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe 
            20                   25                  30        
Pro Glu Pro Val Thr Val Lys Trp Asn Tyr Gly Ala Leu Ser Ser Gly 
        35                   40                  45            
Val Arg Thr Val Ser Ser Val Leu Gln Ser Gly Phe Tyr Ser Leu Ser 
    50                   55                  60                
Ser Leu Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val Ile 
65                   70                  75                  80
Cys Asn Val Ala His Pro Ala Ser Lys Thr Glu Leu Ile Lys Arg Ile 
                85                   90                  95    
Glu Pro Arg Ile Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Cys Pro 
            100                  105                110        
Pro Gly Asn Ile Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
        115                  120                125            
Pro Lys Asp Ala Leu Met Ile Ser Leu Thr Pro Lys Val Thr Cys Val 
    130                  135                140                
Val Val Asp Val Ser Glu Asp Asp Pro Asp Val His Val Ser Trp Phe 
145                  150                155                  160
Val Asp Asn Lys Glu Val His Thr Ala Trp Thr Gln Pro Arg Glu Ala 
                165                  170                175    
Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Ala Leu Pro Ile Gln His 
            180                  185                190        
Gln Asp Trp Met Arg Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
        195                  200                205            
Ala Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Arg 
    210                  215                220                
Ala Gln Thr Pro Gln Val Tyr Thr Ile Pro Pro Pro Arg Glu Gln Met 
225                  230                235                  240
Ser Lys Lys Lys Val Ser Leu Thr Cys Leu Val Thr Asn Phe Phe Ser 
                245                  250                255    
Glu Ala Ile Ser Val Glu Trp Glu Arg Asn Gly Glu Leu Glu Gln Asp 
            260                  265                270        
Tyr Lys Asn Thr Pro Pro Ile Leu Asp Ser Asp Gly Thr Tyr Phe Leu 
        275                  280                285            
Tyr Ser Lys Leu Thr Val Asp Thr Asp Ser Trp Leu Gln Gly Glu Ile 
    290                  295                300                
Phe Thr Cys Ser Val Val His Glu Ala Leu His Asn His His Thr Gln 
305                  310                315                  320
Lys Asn Leu Ser Arg Ser Pro Glu Leu Glu Leu Asn Glu Thr Cys Ala 
                325                  330                335    
Glu Ala Gln Asp Gly Glu Leu Asp Gly Leu Trp Thr Thr Ile Thr Ile 
            340                  345                350        
Phe Ile Ser Leu Phe Leu Leu Ser Val Cys Tyr Ser Ala Ser Val Thr 
        355                  360                365            
Leu Phe Lys Val Lys Trp Ile Phe Ser Ser Val Val Gln Val Lys Gln 
    370                  375                380                
Thr Ala Ile Pro Asp Tyr Arg Asn Met Ile Gly Gln Gly Ala 
385                  390                395            

<210> 12
<211> 326
<212> PRT
<213> Rattus

<220> 
<221> SOURCE
<222> 1..326
<223> /mol_type="protein"
      /organism="Rattus"

<220> 
<221> BINDING
<222> 5..10
<223> /note="SpG-C3 binding epitope"

<220> 
<221> BINDING
<222> 89..96
<223> /note="SpG-C3 binding epitope"

<400> 12
Ala Glu Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Gly Thr Ala 
1               5                   10                   15    
Leu Lys Ser Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                   25                  30        
Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ala Leu Ser Ser 
        35                   40                  45            
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Gly Leu Tyr Thr Leu 
    50                   55                  60                
Thr Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val 
65                   70                  75                  80
Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                   90                  95    
Ile Val Pro Arg Asn Cys Gly Gly Asp Cys Lys Pro Cys Ile Cys Thr 
            100                  105                110        
Gly Ser Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
        115                  120                125            
Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp 
    130                  135                140                
Ile Ser Gln Asp Asp Pro Glu Val His Phe Ser Trp Phe Val Asp Asp 
145                  150                155                  160
Val Glu Val His Thr Ala Gln Thr Arg Pro Pro Glu Glu Gln Phe Asn 
                165                  170                175    
Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Leu His Gln Asp Trp 
            180                  185                190        
Leu Asn Gly Arg Thr Phe Arg Cys Lys Val Thr Ser Ala Ala Phe Pro 
        195                  200                205            
Ser Pro Ile Glu Lys Thr Ile Ser Lys Pro Glu Gly Arg Thr Gln Val 
    210                  215                220                
Pro His Val Tyr Thr Met Ser Pro Thr Lys Glu Glu Met Thr Gln Asn 
225                  230                235                  240
Glu Val Ser Ile Thr Cys Met Val Lys Gly Phe Tyr Pro Pro Asp Ile 
                245                  250                255    
Tyr Val Glu Trp Gln Met Asn Gly Gln Pro Gln Glu Asn Tyr Lys Asn 
            260                  265                270        
Thr Pro Pro Thr Met Asp Thr Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
        275                  280                285            
Leu Asn Val Lys Lys Glu Lys Trp Gln Gln Gly Asn Thr Phe Thr Cys 
    290                  295                300                
Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu 
305                  310                315                  320
Ser His Ser Pro Gly Lys 
                325    

<210> 13
<211> 343
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..343
<223> /mol_type="protein"
      /note="scFv-SpG-C3 (anti-CEA)"
      /organism="artificial sequences"

<400> 13
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                   15    
Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Met Ala Gln Val Lys Leu 
            20                   25                  30        
Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu 
        35                   40                  45            
Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp 
    50                   55                  60                
Leu Arg Gln Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp 
65                   70                  75                  80
Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala 
                85                   90                  95    
Thr Phe Thr Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser 
            100                  105                110        
Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr 
        115                  120                125            
Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val 
    130                  135                140                
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                  150                155                  160
Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
                165                  170                175    
Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val 
            180                  185                190        
Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu 
        195                  200                205            
Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe 
    210                  215                220                
Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met 
225                  230                235                  240
Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr 
                245                  250                255    
Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala 
            260                  265                270        
Ala Gly Gly Ser Gly Gly Thr Thr Tyr Lys Leu Val Ile Asn Gly Lys 
        275                  280                285            
Thr Leu Lys Gly Glu Thr Thr Thr Lys Ala Val Asp Ala Glu Thr Ala 
    290                  295                300                
Glu Lys Ala Phe Lys Gln Tyr Ala Asn Asp Asn Gly Val Asp Gly Val 
305                  310                315                  320
Trp Thr Tyr Asp Asp Ala Thr Lys Thr Phe Thr Val Thr Glu Gly Gly 
                325                  330                335    
Ser His His His His His His 
            340            

<210> 14
<211> 583
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..583
<223> /mol_type="protein"
      /note="scDb-SpG-C3 (anti-CEA x anti-CD3)"
      /organism="artificial sequences"

<400> 14
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                   15    
Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Met Ala Gln Val Lys Leu 
            20                   25                  30        
Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu 
        35                   40                  45            
Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp 
    50                   55                  60                
Leu Arg Gln Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp 
65                   70                  75                  80
Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala 
                85                   90                  95    
Thr Phe Thr Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser 
            100                  105                110        
Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr 
        115                  120                125            
Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val 
    130                  135                140                
Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
145                  150                155                  160
Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                165                  170                175    
Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys 
            180                  185                190        
Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Glu 
        195                  200                205            
Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
    210                  215                220                
Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
225                  230                235                  240
Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys 
                245                  250                255    
Val Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Arg Ala Ser Gly 
            260                  265                270        
Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
        275                  280                285            
Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser 
    290                  295                300                
Phe Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
305                  310                315                  320
Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr 
                325                  330                335    
Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys 
            340                  345                350        
Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
        355                  360                365            
Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr 
    370                  375                380                
Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
385                  390                395                  400
Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
                405                  410                415    
Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val 
            420                  425                430        
Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu 
        435                  440                445            
Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe 
    450                  455                460                
Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met 
465                  470                475                  480
Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr 
                485                  490                495    
Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala 
            500                  505                510        
Ala Gly Gly Ser Gly Gly Thr Thr Tyr Lys Leu Val Ile Asn Gly Lys 
        515                  520                525            
Thr Leu Lys Gly Glu Thr Thr Thr Lys Ala Val Asp Ala Glu Thr Ala 
    530                  535                540                
Glu Lys Ala Phe Lys Gln Tyr Ala Asn Asp Asn Gly Val Asp Gly Val 
545                  550                555                  560
Trp Thr Tyr Asp Asp Ala Thr Lys Thr Phe Thr Val Thr Glu Gly Gly 
                565                  570                575    
Ser His His His His His His 
            580            

<210> 15
<211> 925
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..925
<223> /mol_type="protein"
      /note="SpG-C3-Db-scTRAIL (anti-human EGFR)"
      /organism="artificial sequences"

<400> 15
Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                   15    
Ala His Ser Leu Glu Ala Ser Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
            20                   25                  30        
Ala Thr Thr Tyr Lys Leu Val Ile Asn Gly Lys Thr Leu Lys Gly Glu 
        35                   40                  45            
Thr Thr Thr Lys Ala Val Asp Ala Glu Thr Ala Glu Lys Ala Phe Lys 
    50                   55                  60                
Gln Tyr Ala Asn Asp Asn Gly Val Asp Gly Val Trp Thr Tyr Asp Asp 
65                   70                  75                  80
Ala Thr Lys Thr Phe Thr Val Thr Glu Gly Gly Ser Gly Gly Gly Gly 
                85                   90                  95    
Ser Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            100                  105                110        
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu 
        115                  120                125            
Thr Asn Tyr Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    130                  135                140                
Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr 
145                  150                155                  160
Pro Phe Thr Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                165                  170                175    
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            180                  185                190        
Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp 
        195                  200                205            
Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
    210                  215                220                
Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly Asp 
225                  230                235                  240
Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile 
                245                  250                255    
His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Lys 
            260                  265                270        
Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
        275                  280                285            
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
    290                  295                300                
Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr Thr 
305                  310                315                  320
Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Gly Asn 
                325                  330                335    
Gly Thr Ser Asn Gly Thr Ser Glu Phe Thr Arg Gly Thr Ser Glu Glu 
            340                  345                350        
Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro Leu Val 
        355                  360                365            
Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg 
    370                  375                380                
Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
385                  390                395                  400
Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
                405                  410                415    
Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
            420                  425                430        
Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
        435                  440                445            
Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
    450                  455                460                
Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
465                  470                475                  480
Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
                485                  490                495    
Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
            500                  505                510        
Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
        515                  520                525            
Phe Gly Ala Phe Leu Val Gly Gly Gly Gly Ser Gly Gly Gly Ser Thr 
    530                  535                540                
Ser Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser 
545                  550                555                  560
Pro Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr 
                565                  570                575    
Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn 
            580                  585                590        
Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser 
        595                  600                605            
Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val 
    610                  615                620                
Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg 
625                  630                635                  640
Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val 
                645                  650                655    
Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met 
            660                  665                670        
Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu 
        675                  680                685            
Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg 
    690                  695                700                
Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu 
705                  710                715                  720
Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Gly Gly Ser Gly Gly 
                725                  730                735    
Gly Ser Thr Ser Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln 
            740                  745                750        
Asn Ile Ser Pro Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala 
        755                  760                765            
His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn 
    770                  775                780                
Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser 
785                  790                795                  800
Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly 
                805                  810                815    
Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr 
            820                  825                830        
Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys 
        835                  840                845            
Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile 
    850                  855                860                
Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu 
865                  870                875                  880
Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu 
                885                  890                895    
Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met 
            900                  905                910        
Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
        915                  920                925

<210> 16
<211> 55
<212> PRT
<213> Streptococcus

<220> 
<221> SOURCE
<222> 1..55
<223> /mol_type="protein"
      /organism="Streptococcus"

<400> 16
Thr Tyr Lys Leu Ile Leu Asn Gly Lys Thr Leu Lys Gly Glu Thr Thr 
1               5                   10                   15    
Thr Glu Ala Val Asp Ala Ala Thr Ala Glu Lys Val Phe Lys Gln Tyr 
            20                   25                  30        
Ala Asn Asp Asn Gly Val Asp Gly Glu Trp Thr Tyr Asp Asp Ala Thr 
        35                   40                  45            
Lys Thr Phe Thr Val Thr Glu 
    50                   55

<210> 17
<211> 55
<212> PRT
<213> Streptococcus

<220> 
<221> SOURCE
<222> 1..55
<223> /mol_type="protein"
      /organism="Streptococcus"

<400> 17
Thr Tyr Lys Leu Val Ile Asn Gly Lys Thr Leu Lys Gly Glu Thr Thr 
1               5                   10                   15    
Thr Glu Ala Val Asp Ala Ala Thr Ala Glu Lys Val Phe Lys Gln Tyr 
            20                   25                  30        
Ala Asn Asp Asn Gly Val Asp Gly Glu Trp Thr Tyr Asp Asp Ala Thr 
        35                   40                  45            
Lys Thr Phe Thr Val Thr Glu 
    50                   55

