                         SEQUENCE LISTING

<110>  New York University
       DUSTIN, Michael
       ZANIN-ZHOROV, Alexandra
 
<120>  CONTROLLING REGULATORY T CELL FUNCTION

<130>  29527.1061

<150>  61/534,272
<151>  2011-09-13

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  831
<212>  PRT
<213>  Homo sapien

<400>  1

Leu Asp Asn Pro Lys Cys Ile Asp Arg Ser Lys Pro Ser Glu Pro Ile 
1               5                   10                  15      


Gln Pro Val Asn Thr Trp Glu Ile Ser Ser Leu Pro Ser Ser Thr Val 
            20                  25                  30          


Thr Ser Glu Thr Leu Pro Ser Ser Leu Ser Pro Ser Val Glu Lys Tyr 
        35                  40                  45              


Arg Tyr Gln Asp Glu Asp Thr Pro Pro Gln Glu His Ile Ser Pro Gln 
    50                  55                  60                  


Ile Thr Asn Glu Val Ile Gly Pro Glu Leu Val His Val Ser Glu Lys 
65                  70                  75                  80  


Asn Leu Ser Glu Ile Glu Asn Val His Gly Phe Val Ser His Ser His 
                85                  90                  95      


Ile Ser Pro Ile Lys Pro Thr Glu Ala Val Leu Pro Ser Pro Pro Thr 
            100                 105                 110         


Val Pro Val Ile Pro Val Leu Pro Val Pro Ala Glu Asn Thr Val Ile 
        115                 120                 125             


Leu Pro Thr Ile Pro Gln Ala Asn Pro Pro Pro Val Leu Val Asn Thr 
    130                 135                 140                 


Asp Ser Leu Glu Thr Pro Thr Tyr Val Asn Gly Thr Asp Ala Asp Tyr 
145                 150                 155                 160 


Glu Tyr Glu Glu Ile Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe 
                165                 170                 175     


Ser Ile Ala Gly Gly Thr Asp Asn Pro His Ile Gly Asp Asp Ser Ser 
            180                 185                 190         


Ile Phe Ile Thr Lys Ile Ile Thr Gly Gly Ala Ala Ala Gln Asp Gly 
        195                 200                 205             


Arg Leu Arg Val Asn Asp Cys Ile Leu Arg Val Asn Glu Val Asp Val 
    210                 215                 220                 


Arg Asp Val Thr His Ser Lys Ala Val Glu Ala Leu Lys Glu Ala Gly 
225                 230                 235                 240 


Ser Ile Val Arg Leu Tyr Val Lys Arg Arg Lys Pro Val Ser Glu Lys 
                245                 250                 255     


Ile Met Glu Ile Lys Leu Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser 
            260                 265                 270         


Ile Ala Gly Gly Val Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile 
        275                 280                 285             


Tyr Val Thr Lys Ile Ile Glu Gly Gly Ala Ala His Lys Asp Gly Lys 
    290                 295                 300                 


Leu Gln Ile Gly Asp Lys Leu Leu Ala Val Asn Asn Val Cys Leu Glu 
305                 310                 315                 320 


Glu Val Thr His Glu Glu Ala Val Thr Ala Leu Lys Asn Thr Ser Asp 
                325                 330                 335     


Phe Val Tyr Leu Lys Val Ala Lys Pro Thr Ser Met Tyr Met Asn Asp 
            340                 345                 350         


Gly Tyr Ala Pro Pro Asp Ile Thr Asn Ser Ser Ser Gln Pro Val Asp 
        355                 360                 365             


Asn His Val Ser Pro Ser Ser Phe Leu Gly Gln Thr Pro Ala Ser Pro 
    370                 375                 380                 


Ala Arg Tyr Ser Pro Val Ser Lys Ala Val Leu Gly Asp Asp Glu Ile 
385                 390                 395                 400 


Thr Arg Glu Pro Arg Lys Val Val Leu His Arg Gly Ser Thr Gly Leu 
                405                 410                 415     


Gly Phe Asn Ile Val Gly Gly Glu Asp Gly Glu Gly Ile Phe Ile Ser 
            420                 425                 430         


Phe Ile Leu Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu Leu Arg Lys 
        435                 440                 445             


Gly Asp Arg Ile Ile Ser Val Asn Ser Val Asp Leu Arg Ala Ala Ser 
    450                 455                 460                 


His Glu Gln Ala Ala Ala Ala Leu Lys Asn Ala Gly Gln Ala Val Thr 
465                 470                 475                 480 


Ile Val Ala Gln Tyr Arg Pro Glu Glu Tyr Ser Arg Phe Glu Ala Lys 
                485                 490                 495     


Ile His Asp Leu Arg Glu Gln Met Met Asn Ser Ser Ile Ser Ser Gly 
            500                 505                 510         


Ser Gly Ser Leu Arg Thr Ser Gln Lys Arg Ser Leu Tyr Val Arg Ala 
        515                 520                 525             


Leu Phe Asp Tyr Asp Lys Thr Lys Asp Ser Gly Leu Pro Ser Gln Gly 
    530                 535                 540                 


Leu Asn Phe Lys Phe Gly Asp Ile Leu His Val Ile Asn Ala Ser Asp 
545                 550                 555                 560 


Asp Glu Trp Trp Gln Ala Arg Gln Val Thr Pro Asp Gly Glu Ser Asp 
                565                 570                 575     


Glu Val Gly Val Ile Pro Ser Lys Arg Arg Val Glu Lys Lys Glu Arg 
            580                 585                 590         


Ala Arg Leu Lys Thr Val Lys Phe Asn Ser Lys Thr Arg Asp Lys Gly 
        595                 600                 605             


Glu Ile Pro Asp Asp Met Gly Ser Lys Gly Leu Lys Arg Gly Gln Glu 
    610                 615                 620                 


Glu Tyr Val Leu Ser Tyr Glu Pro Val Asn Gln Gln Glu Val Asn Tyr 
625                 630                 635                 640 


Thr Arg Pro Val Ile Ile Leu Gly Pro Met Lys Asp Arg Ile Asn Asp 
                645                 650                 655     


Asp Leu Ile Ser Glu Phe Pro Asp Lys Phe Gly Ser Cys Val Pro His 
            660                 665                 670         


Thr Thr Arg Pro Lys Arg Asp Tyr Glu Val Asp Gly Arg Asp Tyr His 
        675                 680                 685             


Phe Val Thr Ser Arg Glu Gln Met Glu Lys Asp Ile Gln Glu His Lys 
    690                 695                 700                 


Phe Ile Glu Ala Gly Gln Tyr Asn Asn His Leu Tyr Gly Thr Ser Val 
705                 710                 715                 720 


Gln Ser Val Arg Glu Val Ala Glu Lys Gly Lys His Cys Ile Leu Asp 
                725                 730                 735     


Val Ser Gly Asn Ala Ile Lys Arg Leu Gln Ile Ala Gln Leu Tyr Pro 
            740                 745                 750         


Ile Ser Ile Phe Ile Lys Pro Lys Ser Met Glu Asn Ile Met Glu Met 
        755                 760                 765             


Asn Lys Arg Leu Thr Glu Glu Gln Ala Arg Lys Thr Phe Glu Arg Ala 
    770                 775                 780                 


Met Lys Leu Glu Gln Glu Phe Thr Glu His Phe Thr Ala Ile Val Gln 
785                 790                 795                 800 


Gly Asp Thr Leu Glu Asp Ile Tyr Asn Gln Val Lys Gln Ile Ile Glu 
                805                 810                 815     


Glu Gln Ser Gly Ser Tyr Ile Trp Val Pro Ala Lys Glu Lys Leu 
            820                 825                 830     


<210>  2
<211>  857
<212>  PRT
<213>  Homo sapien

<400>  2

Leu Asp Asn Pro Lys Cys Ile Asp Arg Ser Lys Pro Ser Glu Pro Ile 
1               5                   10                  15      


Gln Pro Val Asn Thr Trp Glu Ile Ser Ser Leu Pro Ser Ser Thr Val 
            20                  25                  30          


Thr Ser Glu Thr Leu Pro Ser Ser Leu Ser Pro Ser Val Glu Lys Tyr 
        35                  40                  45              


Arg Tyr Gln Asp Glu Asp Thr Pro Pro Gln Glu His Ile Ser Pro Gln 
    50                  55                  60                  


Ile Thr Asn Glu Val Ile Gly Pro Glu Leu Val His Val Ser Glu Lys 
65                  70                  75                  80  


Asn Leu Ser Glu Ile Glu Asn Val His Gly Phe Val Ser His Ser His 
                85                  90                  95      


Ile Ser Pro Ile Lys Pro Thr Glu Ala Val Leu Pro Ser Pro Pro Thr 
            100                 105                 110         


Val Pro Val Ile Pro Val Leu Pro Val Pro Ala Glu Asn Thr Val Ile 
        115                 120                 125             


Leu Pro Thr Ile Pro Gln Ala Asn Pro Pro Pro Val Leu Val Asn Thr 
    130                 135                 140                 


Asp Ser Leu Glu Thr Pro Thr Tyr Val Asn Gly Thr Asp Ala Asp Tyr 
145                 150                 155                 160 


Glu Tyr Glu Glu Ile Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe 
                165                 170                 175     


Ser Ile Ala Gly Gly Thr Asp Asn Pro His Ile Gly Asp Asp Ser Ser 
            180                 185                 190         


Ile Phe Ile Thr Lys Ile Ile Thr Gly Gly Ala Ala Ala Gln Asp Gly 
        195                 200                 205             


Arg Leu Arg Val Asn Asp Cys Ile Leu Arg Val Asn Glu Val Asp Val 
    210                 215                 220                 


Arg Asp Val Thr His Ser Lys Ala Val Glu Ala Leu Lys Glu Ala Gly 
225                 230                 235                 240 


Ser Ile Val Arg Leu Tyr Val Lys Arg Arg Lys Pro Val Ser Glu Lys 
                245                 250                 255     


Ile Met Glu Ile Lys Leu Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser 
            260                 265                 270         


Ile Ala Gly Gly Val Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile 
        275                 280                 285             


Tyr Val Thr Lys Ile Ile Glu Gly Gly Ala Ala His Lys Asp Gly Lys 
    290                 295                 300                 


Leu Gln Ile Gly Asp Lys Leu Leu Ala Val Asn Asn Val Cys Leu Glu 
305                 310                 315                 320 


Glu Val Thr His Glu Glu Ala Val Thr Ala Leu Lys Asn Thr Ser Asp 
                325                 330                 335     


Phe Val Tyr Leu Lys Val Ala Lys Pro Thr Ser Met Tyr Met Asn Asp 
            340                 345                 350         


Gly Tyr Ala Pro Pro Asp Ile Thr Asn Ser Ser Ser Gln Pro Val Asp 
        355                 360                 365             


Asn His Val Ser Pro Ser Ser Phe Leu Gly Gln Thr Pro Ala Ser Pro 
    370                 375                 380                 


Ala Arg Tyr Ser Pro Val Ser Lys Ala Val Leu Gly Asp Asp Glu Ile 
385                 390                 395                 400 


Thr Arg Glu Pro Arg Lys Val Val Leu His Arg Gly Ser Thr Gly Leu 
                405                 410                 415     


Gly Phe Asn Ile Val Gly Gly Glu Asp Gly Glu Gly Ile Phe Ile Ser 
            420                 425                 430         


Phe Ile Leu Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu Leu Arg Lys 
        435                 440                 445             


Gly Asp Arg Ile Ile Ser Val Asn Ser Val Asp Leu Arg Ala Ala Ser 
    450                 455                 460                 


His Glu Gln Ala Ala Ala Ala Leu Lys Asn Ala Gly Gln Ala Val Thr 
465                 470                 475                 480 


Ile Val Ala Gln Tyr Arg Pro Glu Glu Tyr Ser Arg Phe Glu Ala Lys 
                485                 490                 495     


Ile His Asp Leu Arg Glu Gln Met Met Asn Ser Ser Ile Ser Ser Gly 
            500                 505                 510         


Ser Gly Ser Leu Arg Thr Ser Gln Lys Arg Ser Leu Tyr Val Arg Ala 
        515                 520                 525             


Leu Phe Asp Tyr Asp Lys Thr Lys Asp Ser Gly Leu Pro Ser Gln Gly 
    530                 535                 540                 


Leu Asn Phe Lys Phe Gly Asp Ile Leu His Val Ile Asn Ala Ser Asp 
545                 550                 555                 560 


Asp Glu Trp Trp Gln Ala Arg Gln Val Thr Pro Asp Gly Glu Ser Asp 
                565                 570                 575     


Glu Val Gly Val Ile Pro Ser Lys Arg Arg Val Glu Lys Lys Glu Arg 
            580                 585                 590         


Ala Arg Leu Lys Thr Val Lys Phe Asn Ser Lys Thr Arg Asp Lys Gly 
        595                 600                 605             


Glu Ile Pro Asp Asp Met Gly Ser Lys Gly Leu Lys His Val Thr Ser 
    610                 615                 620                 


Asn Ala Ser Asp Ser Glu Ser Ser Tyr Leu Ile Leu Ile Thr Asp Glu 
625                 630                 635                 640 


Tyr Gly Cys Ser Lys Gly Arg Gly Gln Glu Glu Tyr Val Leu Ser Tyr 
                645                 650                 655     


Glu Pro Val Asn Gln Gln Glu Val Asn Tyr Thr Arg Pro Val Ile Ile 
            660                 665                 670         


Leu Gly Pro Met Lys Asp Arg Ile Asn Asp Asp Leu Ile Ser Glu Phe 
        675                 680                 685             


Pro Asp Lys Phe Gly Ser Cys Val Pro His Thr Thr Arg Pro Lys Arg 
    690                 695                 700                 


Asp Tyr Glu Val Asp Gly Arg Asp Tyr His Phe Val Thr Ser Arg Glu 
705                 710                 715                 720 


Gln Met Glu Lys Asp Ile Gln Glu His Lys Phe Ile Glu Ala Gly Gln 
                725                 730                 735     


Tyr Asn Asn His Leu Tyr Gly Thr Ser Val Gln Ser Val Arg Glu Val 
            740                 745                 750         


Ala Glu Lys Gly Lys His Cys Ile Leu Asp Val Ser Gly Asn Ala Ile 
        755                 760                 765             


Lys Arg Leu Gln Ile Ala Gln Leu Tyr Pro Ile Ser Ile Phe Ile Lys 
    770                 775                 780                 


Pro Lys Ser Met Glu Asn Ile Met Glu Met Asn Lys Arg Leu Thr Glu 
785                 790                 795                 800 


Glu Gln Ala Arg Lys Thr Phe Glu Arg Ala Met Lys Leu Glu Gln Glu 
                805                 810                 815     


Phe Thr Glu His Phe Thr Ala Ile Val Gln Gly Asp Thr Leu Glu Asp 
            820                 825                 830         


Ile Tyr Asn Gln Val Lys Gln Ile Ile Glu Glu Gln Ser Gly Ser Tyr 
        835                 840                 845             


Ile Trp Val Pro Ala Lys Glu Lys Leu 
    850                 855         


<210>  3
<211>  844
<212>  PRT
<213>  Homo sapien

<400>  3

Leu Asp Asn Pro Lys Cys Ile Asp Arg Ser Lys Pro Ser Glu Pro Ile 
1               5                   10                  15      


Gln Pro Val Asn Thr Trp Glu Ile Ser Ser Leu Pro Ser Ser Thr Val 
            20                  25                  30          


Thr Ser Glu Thr Leu Pro Ser Ser Leu Ser Pro Ser Val Glu Lys Tyr 
        35                  40                  45              


Arg Tyr Gln Asp Glu Asp Thr Pro Pro Gln Glu His Ile Ser Pro Gln 
    50                  55                  60                  


Ile Thr Asn Glu Val Ile Gly Pro Glu Leu Val His Val Ser Glu Lys 
65                  70                  75                  80  


Asn Leu Ser Glu Ile Glu Asn Val His Gly Phe Val Ser His Ser His 
                85                  90                  95      


Ile Ser Pro Ile Lys Pro Thr Glu Ala Val Leu Pro Ser Pro Pro Thr 
            100                 105                 110         


Val Pro Val Ile Pro Val Leu Pro Val Pro Ala Glu Asn Thr Val Ile 
        115                 120                 125             


Leu Pro Thr Ile Pro Gln Ala Asn Pro Pro Pro Val Leu Val Asn Thr 
    130                 135                 140                 


Asp Ser Leu Glu Thr Pro Thr Tyr Val Asn Gly Thr Asp Ala Asp Tyr 
145                 150                 155                 160 


Glu Tyr Glu Glu Ile Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe 
                165                 170                 175     


Ser Ile Ala Gly Gly Thr Asp Asn Pro His Ile Gly Asp Asp Ser Ser 
            180                 185                 190         


Ile Phe Ile Thr Lys Ile Ile Thr Gly Gly Ala Ala Ala Gln Asp Gly 
        195                 200                 205             


Arg Leu Arg Val Asn Asp Cys Ile Leu Arg Val Asn Glu Val Asp Val 
    210                 215                 220                 


Arg Asp Val Thr His Ser Lys Ala Val Glu Ala Leu Lys Glu Ala Gly 
225                 230                 235                 240 


Ser Ile Val Arg Leu Tyr Val Lys Arg Arg Lys Pro Val Ser Glu Lys 
                245                 250                 255     


Ile Met Glu Ile Lys Leu Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser 
            260                 265                 270         


Ile Ala Gly Gly Val Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile 
        275                 280                 285             


Tyr Val Thr Lys Ile Ile Glu Gly Gly Ala Ala His Lys Asp Gly Lys 
    290                 295                 300                 


Leu Gln Ile Gly Asp Lys Leu Leu Ala Val Asn Asn Val Cys Leu Glu 
305                 310                 315                 320 


Glu Val Thr His Glu Glu Ala Val Thr Ala Leu Lys Asn Thr Ser Asp 
                325                 330                 335     


Phe Val Tyr Leu Lys Val Ala Lys Pro Thr Ser Met Tyr Met Asn Asp 
            340                 345                 350         


Gly Tyr Ala Pro Pro Asp Ile Thr Asn Ser Ser Ser Gln Pro Val Asp 
        355                 360                 365             


Asn His Val Ser Pro Ser Ser Phe Leu Gly Gln Thr Pro Ala Ser Pro 
    370                 375                 380                 


Ala Arg Tyr Ser Pro Val Ser Lys Ala Val Leu Gly Asp Asp Glu Ile 
385                 390                 395                 400 


Thr Arg Glu Pro Arg Lys Val Val Leu His Arg Gly Ser Thr Gly Leu 
                405                 410                 415     


Gly Phe Asn Ile Val Gly Gly Glu Asp Gly Glu Gly Ile Phe Ile Ser 
            420                 425                 430         


Phe Ile Leu Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu Leu Arg Lys 
        435                 440                 445             


Gly Asp Arg Ile Ile Ser Val Asn Ser Val Asp Leu Arg Ala Ala Ser 
    450                 455                 460                 


His Glu Gln Ala Ala Ala Ala Leu Lys Asn Ala Gly Gln Ala Val Thr 
465                 470                 475                 480 


Ile Val Ala Gln Tyr Arg Pro Glu Glu Tyr Ser Arg Phe Glu Ala Lys 
                485                 490                 495     


Ile His Asp Leu Arg Glu Gln Met Met Asn Ser Ser Ile Ser Ser Gly 
            500                 505                 510         


Ser Gly Ser Leu Arg Thr Ser Gln Lys Arg Ser Leu Tyr Val Arg Ala 
        515                 520                 525             


Leu Phe Asp Tyr Asp Lys Thr Lys Asp Ser Gly Leu Pro Ser Gln Gly 
    530                 535                 540                 


Leu Asn Phe Lys Phe Gly Asp Ile Leu His Val Ile Asn Ala Ser Asp 
545                 550                 555                 560 


Asp Glu Trp Trp Gln Ala Arg Gln Val Thr Pro Asp Gly Glu Ser Asp 
                565                 570                 575     


Glu Val Gly Val Ile Pro Ser Lys Arg Arg Val Glu Lys Lys Glu Arg 
            580                 585                 590         


Ala Arg Leu Lys Thr Val Lys Phe Asn Ser Lys Thr Arg Asp Lys Gly 
        595                 600                 605             


Glu Ile Pro Asp Asp Met Gly Ser Lys Gly Leu Lys His Val Thr Ser 
    610                 615                 620                 


Asn Ala Ser Asp Ser Glu Ser Ser Tyr Arg Gly Gln Glu Glu Tyr Val 
625                 630                 635                 640 


Leu Ser Tyr Glu Pro Val Asn Gln Gln Glu Val Asn Tyr Thr Arg Pro 
                645                 650                 655     


Val Ile Ile Leu Gly Pro Met Lys Asp Arg Ile Asn Asp Asp Leu Ile 
            660                 665                 670         


Ser Glu Phe Pro Asp Lys Phe Gly Ser Cys Val Pro His Thr Thr Arg 
        675                 680                 685             


Pro Lys Arg Asp Tyr Glu Val Asp Gly Arg Asp Tyr His Phe Val Thr 
    690                 695                 700                 


Ser Arg Glu Gln Met Glu Lys Asp Ile Gln Glu His Lys Phe Ile Glu 
705                 710                 715                 720 


Ala Gly Gln Tyr Asn Asn His Leu Tyr Gly Thr Ser Val Gln Ser Val 
                725                 730                 735     


Arg Glu Val Ala Glu Lys Gly Lys His Cys Ile Leu Asp Val Ser Gly 
            740                 745                 750         


Asn Ala Ile Lys Arg Leu Gln Ile Ala Gln Leu Tyr Pro Ile Ser Ile 
        755                 760                 765             


Phe Ile Lys Pro Lys Ser Met Glu Asn Ile Met Glu Met Asn Lys Arg 
    770                 775                 780                 


Leu Thr Glu Glu Gln Ala Arg Lys Thr Phe Glu Arg Ala Met Lys Leu 
785                 790                 795                 800 


Glu Gln Glu Phe Thr Glu His Phe Thr Ala Ile Val Gln Gly Asp Thr 
                805                 810                 815     


Leu Glu Asp Ile Tyr Asn Gln Val Lys Gln Ile Ile Glu Glu Gln Ser 
            820                 825                 830         


Gly Ser Tyr Ile Trp Val Pro Ala Lys Glu Lys Leu 
        835                 840                 


<210>  4
<211>  793
<212>  PRT
<213>  Homo sapien

<400>  4

Leu Asp Asn Pro Lys Cys Ile Asp Arg Ser Lys Pro Ser Glu Pro Ile 
1               5                   10                  15      


Gln Pro Val Asn Thr Trp Glu Ile Ser Ser Leu Pro Ser Ser Thr Val 
            20                  25                  30          


Thr Ser Glu Thr Leu Pro Ser Ser Leu Ser Pro Ser Val Glu Lys Tyr 
        35                  40                  45              


Arg Tyr Gln Asp Glu Asp Thr Pro Pro Gln Glu His Ile Ser Pro Gln 
    50                  55                  60                  


Ile Thr Asn Glu Val Ile Gly Pro Glu Leu Val His Val Ser Glu Lys 
65                  70                  75                  80  


Asn Leu Ser Glu Ile Glu Asn Val His Gly Phe Val Ser His Ser His 
                85                  90                  95      


Ile Ser Pro Ile Lys Val Asn Gly Thr Asp Ala Asp Tyr Glu Tyr Glu 
            100                 105                 110         


Glu Ile Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala 
        115                 120                 125             


Gly Gly Thr Asp Asn Pro His Ile Gly Asp Asp Ser Ser Ile Phe Ile 
    130                 135                 140                 


Thr Lys Ile Ile Thr Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg 
145                 150                 155                 160 


Val Asn Asp Cys Ile Leu Arg Val Asn Glu Val Asp Val Arg Asp Val 
                165                 170                 175     


Thr His Ser Lys Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val 
            180                 185                 190         


Arg Leu Tyr Val Lys Arg Arg Lys Pro Val Ser Glu Lys Ile Met Glu 
        195                 200                 205             


Ile Lys Leu Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly 
    210                 215                 220                 


Gly Val Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr 
225                 230                 235                 240 


Lys Ile Ile Glu Gly Gly Ala Ala His Lys Asp Gly Lys Leu Gln Ile 
                245                 250                 255     


Gly Asp Lys Leu Leu Ala Val Asn Asn Val Cys Leu Glu Glu Val Thr 
            260                 265                 270         


His Glu Glu Ala Val Thr Ala Leu Lys Asn Thr Ser Asp Phe Val Tyr 
        275                 280                 285             


Leu Lys Val Ala Lys Pro Thr Ser Met Tyr Met Asn Asp Gly Tyr Ala 
    290                 295                 300                 


Pro Pro Asp Ile Thr Asn Ser Ser Ser Gln Pro Val Asp Asn His Val 
305                 310                 315                 320 


Ser Pro Ser Ser Phe Leu Gly Gln Thr Pro Ala Ser Pro Ala Arg Tyr 
                325                 330                 335     


Ser Pro Val Ser Lys Ala Val Leu Gly Asp Asp Glu Ile Thr Arg Glu 
            340                 345                 350         


Pro Arg Lys Val Val Leu His Arg Gly Ser Thr Gly Leu Gly Phe Asn 
        355                 360                 365             


Ile Val Gly Gly Glu Asp Gly Glu Gly Ile Phe Ile Ser Phe Ile Leu 
    370                 375                 380                 


Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu Leu Arg Lys Gly Asp Arg 
385                 390                 395                 400 


Ile Ile Ser Val Asn Ser Val Asp Leu Arg Ala Ala Ser His Glu Gln 
                405                 410                 415     


Ala Ala Ala Ala Leu Lys Asn Ala Gly Gln Ala Val Thr Ile Val Ala 
            420                 425                 430         


Gln Tyr Arg Pro Glu Glu Tyr Ser Arg Phe Glu Ala Lys Ile His Asp 
        435                 440                 445             


Leu Arg Glu Gln Met Met Asn Ser Ser Ile Ser Ser Gly Ser Gly Ser 
    450                 455                 460                 


Leu Arg Thr Ser Gln Lys Arg Ser Leu Tyr Val Arg Ala Leu Phe Asp 
465                 470                 475                 480 


Tyr Asp Lys Thr Lys Asp Ser Gly Leu Pro Ser Gln Gly Leu Asn Phe 
                485                 490                 495     


Lys Phe Gly Asp Ile Leu His Val Ile Asn Ala Ser Asp Asp Glu Trp 
            500                 505                 510         


Trp Gln Ala Arg Gln Val Thr Pro Asp Gly Glu Ser Asp Glu Val Gly 
        515                 520                 525             


Val Ile Pro Ser Lys Arg Arg Val Glu Lys Lys Glu Arg Ala Arg Leu 
    530                 535                 540                 


Lys Thr Val Lys Phe Asn Ser Lys Thr Arg Asp Lys Gly Glu Ile Pro 
545                 550                 555                 560 


Asp Asp Met Gly Ser Lys Gly Leu Lys His Val Thr Ser Asn Ala Ser 
                565                 570                 575     


Asp Ser Glu Ser Ser Tyr Arg Gly Gln Glu Glu Tyr Val Leu Ser Tyr 
            580                 585                 590         


Glu Pro Val Asn Gln Gln Glu Val Asn Tyr Thr Arg Pro Val Ile Ile 
        595                 600                 605             


Leu Gly Pro Met Lys Asp Arg Ile Asn Asp Asp Leu Ile Ser Glu Phe 
    610                 615                 620                 


Pro Asp Lys Phe Gly Ser Cys Val Pro His Thr Thr Arg Pro Lys Arg 
625                 630                 635                 640 


Asp Tyr Glu Val Asp Gly Arg Asp Tyr His Phe Val Thr Ser Arg Glu 
                645                 650                 655     


Gln Met Glu Lys Asp Ile Gln Glu His Lys Phe Ile Glu Ala Gly Gln 
            660                 665                 670         


Tyr Asn Asn His Leu Tyr Gly Thr Ser Val Gln Ser Val Arg Glu Val 
        675                 680                 685             


Ala Glu Lys Gly Lys His Cys Ile Leu Asp Val Ser Gly Asn Ala Ile 
    690                 695                 700                 


Lys Arg Leu Gln Ile Ala Gln Leu Tyr Pro Ile Ser Ile Phe Ile Lys 
705                 710                 715                 720 


Pro Lys Ser Met Glu Asn Ile Met Glu Met Asn Lys Arg Leu Thr Glu 
                725                 730                 735     


Glu Gln Ala Arg Lys Thr Phe Glu Arg Ala Met Lys Leu Glu Gln Glu 
            740                 745                 750         


Phe Thr Glu His Phe Thr Ala Ile Val Gln Gly Asp Thr Leu Glu Asp 
        755                 760                 765             


Ile Tyr Asn Gln Val Lys Gln Ile Ile Glu Glu Gln Ser Gly Ser Tyr 
    770                 775                 780                 


Ile Trp Val Pro Ala Lys Glu Lys Leu 
785                 790             


<210>  5
<211>  811
<212>  PRT
<213>  Homo sapien

<400>  5

Leu Asp Asn Pro Lys Cys Ile Asp Arg Ser Lys Pro Ser Glu Pro Ile 
1               5                   10                  15      


Gln Pro Val Asn Thr Trp Glu Ile Ser Ser Leu Pro Ser Ser Thr Val 
            20                  25                  30          


Thr Ser Glu Thr Leu Pro Ser Ser Leu Ser Pro Ser Val Glu Lys Tyr 
        35                  40                  45              


Arg Tyr Gln Asp Glu Asp Thr Pro Pro Gln Glu His Ile Ser Pro Gln 
    50                  55                  60                  


Ile Thr Asn Glu Val Ile Gly Pro Glu Leu Val His Val Ser Glu Lys 
65                  70                  75                  80  


Asn Leu Ser Glu Ile Glu Asn Val His Gly Phe Val Ser His Ser His 
                85                  90                  95      


Ile Ser Pro Ile Lys Ala Asn Pro Pro Pro Val Leu Val Asn Thr Asp 
            100                 105                 110         


Ser Leu Glu Thr Pro Thr Tyr Val Asn Gly Thr Asp Ala Asp Tyr Glu 
        115                 120                 125             


Tyr Glu Glu Ile Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser 
    130                 135                 140                 


Ile Ala Gly Gly Thr Asp Asn Pro His Ile Gly Asp Asp Ser Ser Ile 
145                 150                 155                 160 


Phe Ile Thr Lys Ile Ile Thr Gly Gly Ala Ala Ala Gln Asp Gly Arg 
                165                 170                 175     


Leu Arg Val Asn Asp Cys Ile Leu Arg Val Asn Glu Val Asp Val Arg 
            180                 185                 190         


Asp Val Thr His Ser Lys Ala Val Glu Ala Leu Lys Glu Ala Gly Ser 
        195                 200                 205             


Ile Val Arg Leu Tyr Val Lys Arg Arg Lys Pro Val Ser Glu Lys Ile 
    210                 215                 220                 


Met Glu Ile Lys Leu Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile 
225                 230                 235                 240 


Ala Gly Gly Val Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr 
                245                 250                 255     


Val Thr Lys Ile Ile Glu Gly Gly Ala Ala His Lys Asp Gly Lys Leu 
            260                 265                 270         


Gln Ile Gly Asp Lys Leu Leu Ala Val Asn Asn Val Cys Leu Glu Glu 
        275                 280                 285             


Val Thr His Glu Glu Ala Val Thr Ala Leu Lys Asn Thr Ser Asp Phe 
    290                 295                 300                 


Val Tyr Leu Lys Val Ala Lys Pro Thr Ser Met Tyr Met Asn Asp Gly 
305                 310                 315                 320 


Tyr Ala Pro Pro Asp Ile Thr Asn Ser Ser Ser Gln Pro Val Asp Asn 
                325                 330                 335     


His Val Ser Pro Ser Ser Phe Leu Gly Gln Thr Pro Ala Ser Pro Ala 
            340                 345                 350         


Arg Tyr Ser Pro Val Ser Lys Ala Val Leu Gly Asp Asp Glu Ile Thr 
        355                 360                 365             


Arg Glu Pro Arg Lys Val Val Leu His Arg Gly Ser Thr Gly Leu Gly 
    370                 375                 380                 


Phe Asn Ile Val Gly Gly Glu Asp Gly Glu Gly Ile Phe Ile Ser Phe 
385                 390                 395                 400 


Ile Leu Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu Leu Arg Lys Gly 
                405                 410                 415     


Asp Arg Ile Ile Ser Val Asn Ser Val Asp Leu Arg Ala Ala Ser His 
            420                 425                 430         


Glu Gln Ala Ala Ala Ala Leu Lys Asn Ala Gly Gln Ala Val Thr Ile 
        435                 440                 445             


Val Ala Gln Tyr Arg Pro Glu Glu Tyr Ser Arg Phe Glu Ala Lys Ile 
    450                 455                 460                 


His Asp Leu Arg Glu Gln Met Met Asn Ser Ser Ile Ser Ser Gly Ser 
465                 470                 475                 480 


Gly Ser Leu Arg Thr Ser Gln Lys Arg Ser Leu Tyr Val Arg Ala Leu 
                485                 490                 495     


Phe Asp Tyr Asp Lys Thr Lys Asp Ser Gly Leu Pro Ser Gln Gly Leu 
            500                 505                 510         


Asn Phe Lys Phe Gly Asp Ile Leu His Val Ile Asn Ala Ser Asp Asp 
        515                 520                 525             


Glu Trp Trp Gln Ala Arg Gln Val Thr Pro Asp Gly Glu Ser Asp Glu 
    530                 535                 540                 


Val Gly Val Ile Pro Ser Lys Arg Arg Val Glu Lys Lys Glu Arg Ala 
545                 550                 555                 560 


Arg Leu Lys Thr Val Lys Phe Asn Ser Lys Thr Arg Asp Lys Gly Glu 
                565                 570                 575     


Ile Pro Asp Asp Met Gly Ser Lys Gly Leu Lys His Val Thr Ser Asn 
            580                 585                 590         


Ala Ser Asp Ser Glu Ser Ser Tyr Arg Gly Gln Glu Glu Tyr Val Leu 
        595                 600                 605             


Ser Tyr Glu Pro Val Asn Gln Gln Glu Val Asn Tyr Thr Arg Pro Val 
    610                 615                 620                 


Ile Ile Leu Gly Pro Met Lys Asp Arg Ile Asn Asp Asp Leu Ile Ser 
625                 630                 635                 640 


Glu Phe Pro Asp Lys Phe Gly Ser Cys Val Pro His Thr Thr Arg Pro 
                645                 650                 655     


Lys Arg Asp Tyr Glu Val Asp Gly Arg Asp Tyr His Phe Val Thr Ser 
            660                 665                 670         


Arg Glu Gln Met Glu Lys Asp Ile Gln Glu His Lys Phe Ile Glu Ala 
        675                 680                 685             


Gly Gln Tyr Asn Asn His Leu Tyr Gly Thr Ser Val Gln Ser Val Arg 
    690                 695                 700                 


Glu Val Ala Glu Lys Gly Lys His Cys Ile Leu Asp Val Ser Gly Asn 
705                 710                 715                 720 


Ala Ile Lys Arg Leu Gln Ile Ala Gln Leu Tyr Pro Ile Ser Ile Phe 
                725                 730                 735     


Ile Lys Pro Lys Ser Met Glu Asn Ile Met Glu Met Asn Lys Arg Leu 
            740                 745                 750         


Thr Glu Glu Gln Ala Arg Lys Thr Phe Glu Arg Ala Met Lys Leu Glu 
        755                 760                 765             


Gln Glu Phe Thr Glu His Phe Thr Ala Ile Val Gln Gly Asp Thr Leu 
    770                 775                 780                 


Glu Asp Ile Tyr Asn Gln Val Lys Gln Ile Ile Glu Glu Gln Ser Gly 
785                 790                 795                 800 


Ser Tyr Ile Trp Val Pro Ala Lys Glu Lys Leu 
                805                 810     


<210>  6
<211>  866
<212>  PRT
<213>  Homo sapien

<400>  6

Leu Asp Asn Pro Lys Cys Ile Asp Arg Ser Lys Pro Ser Glu Pro Ile 
1               5                   10                  15      


Gln Pro Val Asn Thr Trp Glu Ile Ser Ser Leu Pro Ser Ser Thr Val 
            20                  25                  30          


Thr Ser Glu Thr Leu Pro Ser Ser Leu Ser Pro Ser Val Glu Lys Tyr 
        35                  40                  45              


Arg Tyr Gln Asp Glu Asp Thr Pro Pro Gln Glu His Ile Ser Pro Gln 
    50                  55                  60                  


Ile Thr Asn Glu Val Ile Gly Pro Glu Leu Val His Val Ser Glu Lys 
65                  70                  75                  80  


Asn Leu Ser Glu Ile Glu Asn Val His Gly Phe Val Ser His Ser His 
                85                  90                  95      


Ile Ser Pro Ile Lys Pro Thr Glu Ala Val Leu Pro Ser Pro Pro Thr 
            100                 105                 110         


Val Pro Val Ile Pro Val Leu Pro Val Pro Ala Glu Asn Thr Val Ile 
        115                 120                 125             


Leu Pro Thr Ile Pro Gln Ala Asn Pro Pro Pro Val Leu Val Asn Thr 
    130                 135                 140                 


Asp Ser Leu Glu Thr Pro Thr Tyr Val Asn Gly Thr Asp Ala Asp Tyr 
145                 150                 155                 160 


Glu Tyr Glu Glu Ile Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe 
                165                 170                 175     


Ser Ile Ala Gly Gly Thr Asp Asn Pro His Ile Gly Asp Asp Ser Ser 
            180                 185                 190         


Ile Phe Ile Thr Lys Ile Ile Thr Gly Gly Ala Ala Ala Gln Asp Gly 
        195                 200                 205             


Arg Leu Arg Val Asn Asp Cys Ile Leu Arg Val Asn Glu Val Asp Val 
    210                 215                 220                 


Arg Asp Val Thr His Ser Lys Ala Val Glu Ala Leu Lys Glu Ala Gly 
225                 230                 235                 240 


Ser Ile Val Arg Leu Tyr Val Lys Arg Arg Lys Pro Val Ser Glu Lys 
                245                 250                 255     


Ile Met Glu Ile Lys Leu Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser 
            260                 265                 270         


Ile Ala Gly Gly Val Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile 
        275                 280                 285             


Tyr Val Thr Lys Ile Ile Glu Gly Gly Ala Ala His Lys Asp Gly Lys 
    290                 295                 300                 


Leu Gln Ile Gly Asp Lys Leu Leu Ala Val Asn Asn Val Cys Leu Glu 
305                 310                 315                 320 


Glu Val Thr His Glu Glu Ala Val Thr Ala Leu Lys Asn Thr Ser Asp 
                325                 330                 335     


Phe Val Tyr Leu Lys Val Ala Lys Pro Thr Ser Met Tyr Met Asn Asp 
            340                 345                 350         


Gly Tyr Ala Pro Pro Asp Ile Thr Asn Ser Ser Ser Gln Pro Val Asp 
        355                 360                 365             


Asn His Val Ser Pro Ser Ser Phe Leu Gly Gln Thr Pro Ala Ser Pro 
    370                 375                 380                 


Ala Arg Tyr Ser Pro Val Ser Lys Ala Val Leu Gly Asp Asp Glu Ile 
385                 390                 395                 400 


Thr Arg Glu Pro Arg Lys Val Val Leu His Arg Gly Ser Thr Gly Leu 
                405                 410                 415     


Gly Phe Asn Ile Val Gly Gly Glu Asp Gly Glu Gly Ile Phe Ile Ser 
            420                 425                 430         


Phe Ile Leu Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu Leu Arg Lys 
        435                 440                 445             


Gly Asp Arg Ile Ile Ser Val Asn Ser Val Asp Leu Arg Ala Ala Ser 
    450                 455                 460                 


His Glu Gln Ala Ala Ala Ala Leu Lys Asn Ala Gly Gln Ala Val Thr 
465                 470                 475                 480 


Ile Val Ala Gln Tyr Arg Pro Glu Glu Tyr Ser Arg Phe Glu Ala Lys 
                485                 490                 495     


Ile His Asp Leu Arg Glu Gln Met Met Asn Ser Ser Ile Ser Ser Gly 
            500                 505                 510         


Ser Gly Ser Leu Arg Thr Ser Gln Lys Arg Ser Leu Tyr Val Arg Ala 
        515                 520                 525             


Leu Phe Asp Tyr Asp Lys Thr Lys Asp Ser Gly Leu Pro Ser Gln Gly 
    530                 535                 540                 


Leu Asn Phe Lys Phe Gly Asp Ile Leu His Val Ile Asn Ala Ser Asp 
545                 550                 555                 560 


Asp Glu Trp Trp Gln Ala Arg Gln Val Thr Pro Asp Gly Glu Ser Asp 
                565                 570                 575     


Glu Val Gly Val Ile Pro Ser Lys Arg Arg Val Glu Lys Lys Glu Arg 
            580                 585                 590         


Ala Arg Leu Lys Thr Val Lys Phe Asn Ser Lys Thr Arg Asp Lys Gly 
        595                 600                 605             


Gln Ser Phe Asn Asp Lys Arg Lys Lys Asn Leu Phe Ser Arg Lys Phe 
    610                 615                 620                 


Pro Phe Tyr Lys Asn Lys Asp Gln Ser Glu Gln Glu Thr Ser Asp Ala 
625                 630                 635                 640 


Asp Gln His Val Thr Ser Asn Ala Ser Asp Ser Glu Ser Ser Tyr Arg 
                645                 650                 655     


Gly Gln Glu Glu Tyr Val Leu Ser Tyr Glu Pro Val Asn Gln Gln Glu 
            660                 665                 670         


Val Asn Tyr Thr Arg Pro Val Ile Ile Leu Gly Pro Met Lys Asp Arg 
        675                 680                 685             


Ile Asn Asp Asp Leu Ile Ser Glu Phe Pro Asp Lys Phe Gly Ser Cys 
    690                 695                 700                 


Val Pro His Thr Thr Arg Pro Lys Arg Asp Tyr Glu Val Asp Gly Arg 
705                 710                 715                 720 


Asp Tyr His Phe Val Thr Ser Arg Glu Gln Met Glu Lys Asp Ile Gln 
                725                 730                 735     


Glu His Lys Phe Ile Glu Ala Gly Gln Tyr Asn Asn His Leu Tyr Gly 
            740                 745                 750         


Thr Ser Val Gln Ser Val Arg Glu Val Ala Glu Lys Gly Lys His Cys 
        755                 760                 765             


Ile Leu Asp Val Ser Gly Asn Ala Ile Lys Arg Leu Gln Ile Ala Gln 
    770                 775                 780                 


Leu Tyr Pro Ile Ser Ile Phe Ile Lys Pro Lys Ser Met Glu Asn Ile 
785                 790                 795                 800 


Met Glu Met Asn Lys Arg Leu Thr Glu Glu Gln Ala Arg Lys Thr Phe 
                805                 810                 815     


Glu Arg Ala Met Lys Leu Glu Gln Glu Phe Thr Glu His Phe Thr Ala 
            820                 825                 830         


Ile Val Gln Gly Asp Thr Leu Glu Asp Ile Tyr Asn Gln Val Lys Gln 
        835                 840                 845             


Ile Ile Glu Glu Gln Ser Gly Ser Tyr Ile Trp Val Pro Ala Lys Glu 
    850                 855                 860                 


Lys Leu 
865     


<210>  7
<211>  833
<212>  PRT
<213>  Homo sapien

<400>  7

Leu Asp Asn Pro Lys Cys Ile Asp Arg Ser Lys Pro Ser Glu Pro Ile 
1               5                   10                  15      


Gln Pro Val Asn Thr Trp Glu Ile Ser Ser Leu Pro Ser Ser Thr Val 
            20                  25                  30          


Thr Ser Glu Thr Leu Pro Ser Ser Leu Ser Pro Ser Val Glu Lys Tyr 
        35                  40                  45              


Arg Tyr Gln Asp Glu Asp Thr Pro Pro Gln Glu His Ile Ser Pro Gln 
    50                  55                  60                  


Ile Thr Asn Glu Val Ile Gly Pro Glu Leu Val His Val Ser Glu Lys 
65                  70                  75                  80  


Asn Leu Ser Glu Ile Glu Asn Val His Gly Phe Val Ser His Ser His 
                85                  90                  95      


Ile Ser Pro Ile Lys Ala Asn Pro Pro Pro Val Leu Val Asn Thr Asp 
            100                 105                 110         


Ser Leu Glu Thr Pro Thr Tyr Val Asn Gly Thr Asp Ala Asp Tyr Glu 
        115                 120                 125             


Tyr Glu Glu Ile Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser 
    130                 135                 140                 


Ile Ala Gly Gly Thr Asp Asn Pro His Ile Gly Asp Asp Ser Ser Ile 
145                 150                 155                 160 


Phe Ile Thr Lys Ile Ile Thr Gly Gly Ala Ala Ala Gln Asp Gly Arg 
                165                 170                 175     


Leu Arg Val Asn Asp Cys Ile Leu Arg Val Asn Glu Val Asp Val Arg 
            180                 185                 190         


Asp Val Thr His Ser Lys Ala Val Glu Ala Leu Lys Glu Ala Gly Ser 
        195                 200                 205             


Ile Val Arg Leu Tyr Val Lys Arg Arg Lys Pro Val Ser Glu Lys Ile 
    210                 215                 220                 


Met Glu Ile Lys Leu Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile 
225                 230                 235                 240 


Ala Gly Gly Val Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr 
                245                 250                 255     


Val Thr Lys Ile Ile Glu Gly Gly Ala Ala His Lys Asp Gly Lys Leu 
            260                 265                 270         


Gln Ile Gly Asp Lys Leu Leu Ala Val Asn Asn Val Cys Leu Glu Glu 
        275                 280                 285             


Val Thr His Glu Glu Ala Val Thr Ala Leu Lys Asn Thr Ser Asp Phe 
    290                 295                 300                 


Val Tyr Leu Lys Val Ala Lys Pro Thr Ser Met Tyr Met Asn Asp Gly 
305                 310                 315                 320 


Tyr Ala Pro Pro Asp Ile Thr Asn Ser Ser Ser Gln Pro Val Asp Asn 
                325                 330                 335     


His Val Ser Pro Ser Ser Phe Leu Gly Gln Thr Pro Ala Ser Pro Ala 
            340                 345                 350         


Arg Tyr Ser Pro Val Ser Lys Ala Val Leu Gly Asp Asp Glu Ile Thr 
        355                 360                 365             


Arg Glu Pro Arg Lys Val Val Leu His Arg Gly Ser Thr Gly Leu Gly 
    370                 375                 380                 


Phe Asn Ile Val Gly Gly Glu Asp Gly Glu Gly Ile Phe Ile Ser Phe 
385                 390                 395                 400 


Ile Leu Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu Leu Arg Lys Gly 
                405                 410                 415     


Asp Arg Ile Ile Ser Val Asn Ser Val Asp Leu Arg Ala Ala Ser His 
            420                 425                 430         


Glu Gln Ala Ala Ala Ala Leu Lys Asn Ala Gly Gln Ala Val Thr Ile 
        435                 440                 445             


Val Ala Gln Tyr Arg Pro Glu Glu Tyr Ser Arg Phe Glu Ala Lys Ile 
    450                 455                 460                 


His Asp Leu Arg Glu Gln Met Met Asn Ser Ser Ile Ser Ser Gly Ser 
465                 470                 475                 480 


Gly Ser Leu Arg Thr Ser Gln Lys Arg Ser Leu Tyr Val Arg Ala Leu 
                485                 490                 495     


Phe Asp Tyr Asp Lys Thr Lys Asp Ser Gly Leu Pro Ser Gln Gly Leu 
            500                 505                 510         


Asn Phe Lys Phe Gly Asp Ile Leu His Val Ile Asn Ala Ser Asp Asp 
        515                 520                 525             


Glu Trp Trp Gln Ala Arg Gln Val Thr Pro Asp Gly Glu Ser Asp Glu 
    530                 535                 540                 


Val Gly Val Ile Pro Ser Lys Arg Arg Val Glu Lys Lys Glu Arg Ala 
545                 550                 555                 560 


Arg Leu Lys Thr Val Lys Phe Asn Ser Lys Thr Arg Asp Lys Gly Gln 
                565                 570                 575     


Ser Phe Asn Asp Lys Arg Lys Lys Asn Leu Phe Ser Arg Lys Phe Pro 
            580                 585                 590         


Phe Tyr Lys Asn Lys Asp Gln Ser Glu Gln Glu Thr Ser Asp Ala Asp 
        595                 600                 605             


Gln His Val Thr Ser Asn Ala Ser Asp Ser Glu Ser Ser Tyr Arg Gly 
    610                 615                 620                 


Gln Glu Glu Tyr Val Leu Ser Tyr Glu Pro Val Asn Gln Gln Glu Val 
625                 630                 635                 640 


Asn Tyr Thr Arg Pro Val Ile Ile Leu Gly Pro Met Lys Asp Arg Ile 
                645                 650                 655     


Asn Asp Asp Leu Ile Ser Glu Phe Pro Asp Lys Phe Gly Ser Cys Val 
            660                 665                 670         


Pro His Thr Thr Arg Pro Lys Arg Asp Tyr Glu Val Asp Gly Arg Asp 
        675                 680                 685             


Tyr His Phe Val Thr Ser Arg Glu Gln Met Glu Lys Asp Ile Gln Glu 
    690                 695                 700                 


His Lys Phe Ile Glu Ala Gly Gln Tyr Asn Asn His Leu Tyr Gly Thr 
705                 710                 715                 720 


Ser Val Gln Ser Val Arg Glu Val Ala Glu Lys Gly Lys His Cys Ile 
                725                 730                 735     


Leu Asp Val Ser Gly Asn Ala Ile Lys Arg Leu Gln Ile Ala Gln Leu 
            740                 745                 750         


Tyr Pro Ile Ser Ile Phe Ile Lys Pro Lys Ser Met Glu Asn Ile Met 
        755                 760                 765             


Glu Met Asn Lys Arg Leu Thr Glu Glu Gln Ala Arg Lys Thr Phe Glu 
    770                 775                 780                 


Arg Ala Met Lys Leu Glu Gln Glu Phe Thr Glu His Phe Thr Ala Ile 
785                 790                 795                 800 


Val Gln Gly Asp Thr Leu Glu Asp Ile Tyr Asn Gln Val Lys Gln Ile 
                805                 810                 815     


Ile Glu Glu Gln Ser Gly Ser Tyr Ile Trp Val Pro Ala Lys Glu Lys 
            820                 825                 830         


Leu 
    


<210>  8
<211>  770
<212>  PRT
<213>  Homo sapien

<400>  8

Leu Asp Asn Pro Lys Cys Ile Asp Arg Ser Lys Pro Ser Glu Pro Ile 
1               5                   10                  15      


Gln Pro Val Asn Thr Trp Glu Ile Ser Ser Leu Pro Ser Ser Thr Val 
            20                  25                  30          


Thr Ser Glu Thr Leu Pro Ser Ser Leu Ser Pro Ser Val Glu Lys Tyr 
        35                  40                  45              


Arg Tyr Gln Asp Glu Asp Thr Pro Pro Gln Glu His Ile Ser Pro Gln 
    50                  55                  60                  


Ile Thr Asn Glu Val Ile Gly Pro Glu Leu Val His Val Ser Glu Lys 
65                  70                  75                  80  


Asn Leu Ser Glu Ile Glu Asn Val His Gly Phe Val Ser His Ser His 
                85                  90                  95      


Ile Ser Pro Ile Lys Val Asn Gly Thr Asp Ala Asp Tyr Glu Tyr Glu 
            100                 105                 110         


Glu Ile Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala 
        115                 120                 125             


Gly Gly Thr Asp Asn Pro His Ile Gly Asp Asp Ser Ser Ile Phe Ile 
    130                 135                 140                 


Thr Lys Ile Ile Thr Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg 
145                 150                 155                 160 


Val Asn Asp Cys Ile Leu Arg Val Asn Glu Val Asp Val Arg Asp Val 
                165                 170                 175     


Thr His Ser Lys Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val 
            180                 185                 190         


Arg Leu Tyr Val Lys Arg Arg Lys Pro Val Ser Glu Lys Ile Met Glu 
        195                 200                 205             


Ile Lys Leu Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly 
    210                 215                 220                 


Gly Val Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr 
225                 230                 235                 240 


Lys Ile Ile Glu Gly Gly Ala Ala His Lys Asp Gly Lys Leu Gln Ile 
                245                 250                 255     


Gly Asp Lys Leu Leu Ala Val Asn Asn Val Cys Leu Glu Glu Val Thr 
            260                 265                 270         


His Glu Glu Ala Val Thr Ala Leu Lys Asn Thr Ser Asp Phe Val Tyr 
        275                 280                 285             


Leu Lys Val Ala Lys Pro Thr Ser Met Tyr Met Asn Asp Gly Tyr Ala 
    290                 295                 300                 


Pro Pro Asp Ile Thr Asn Ser Ser Ser Gln Pro Val Asp Asn His Val 
305                 310                 315                 320 


Ser Pro Ser Ser Phe Leu Gly Gln Thr Pro Ala Ser Pro Ala Arg Tyr 
                325                 330                 335     


Ser Pro Val Ser Lys Ala Val Leu Gly Asp Asp Glu Ile Thr Arg Glu 
            340                 345                 350         


Pro Arg Lys Val Val Leu His Arg Gly Ser Thr Gly Leu Gly Phe Asn 
        355                 360                 365             


Ile Val Gly Gly Glu Asp Gly Glu Gly Ile Phe Ile Ser Phe Ile Leu 
    370                 375                 380                 


Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu Leu Arg Lys Gly Asp Arg 
385                 390                 395                 400 


Ile Ile Ser Val Asn Ser Val Asp Leu Arg Ala Ala Ser His Glu Gln 
                405                 410                 415     


Ala Ala Ala Ala Leu Lys Asn Ala Gly Gln Ala Val Thr Ile Val Ala 
            420                 425                 430         


Gln Tyr Arg Pro Glu Glu Tyr Ser Arg Phe Glu Ala Lys Ile His Asp 
        435                 440                 445             


Leu Arg Glu Gln Met Met Asn Ser Ser Ile Ser Ser Gly Ser Gly Ser 
    450                 455                 460                 


Leu Arg Thr Ser Gln Lys Arg Ser Leu Tyr Val Arg Ala Leu Phe Asp 
465                 470                 475                 480 


Tyr Asp Lys Thr Lys Asp Ser Gly Leu Pro Ser Gln Gly Leu Asn Phe 
                485                 490                 495     


Lys Phe Gly Asp Ile Leu His Val Ile Asn Ala Ser Asp Asp Glu Trp 
            500                 505                 510         


Trp Gln Ala Arg Gln Val Thr Pro Asp Gly Glu Ser Asp Glu Val Gly 
        515                 520                 525             


Val Ile Pro Ser Lys Arg Arg Val Glu Lys Lys Glu Arg Ala Arg Leu 
    530                 535                 540                 


Lys Thr Val Lys Phe Asn Ser Lys Thr Arg Asp Lys Gly Asp Ser Arg 
545                 550                 555                 560 


Gly Gln Glu Glu Tyr Val Leu Ser Tyr Glu Pro Val Asn Gln Gln Glu 
                565                 570                 575     


Val Asn Tyr Thr Arg Pro Val Ile Ile Leu Gly Pro Met Lys Asp Arg 
            580                 585                 590         


Ile Asn Asp Asp Leu Ile Ser Glu Phe Pro Asp Lys Phe Gly Ser Cys 
        595                 600                 605             


Val Pro His Thr Thr Arg Pro Lys Arg Asp Tyr Glu Val Asp Gly Arg 
    610                 615                 620                 


Asp Tyr His Phe Val Thr Ser Arg Glu Gln Met Glu Lys Asp Ile Gln 
625                 630                 635                 640 


Glu His Lys Phe Ile Glu Ala Gly Gln Tyr Asn Asn His Leu Tyr Gly 
                645                 650                 655     


Thr Ser Val Gln Ser Val Arg Glu Val Ala Glu Lys Gly Lys His Cys 
            660                 665                 670         


Ile Leu Asp Val Ser Gly Asn Ala Ile Lys Arg Leu Gln Ile Ala Gln 
        675                 680                 685             


Leu Tyr Pro Ile Ser Ile Phe Ile Lys Pro Lys Ser Met Glu Asn Ile 
    690                 695                 700                 


Met Glu Met Asn Lys Arg Leu Thr Glu Glu Gln Ala Arg Lys Thr Phe 
705                 710                 715                 720 


Glu Arg Ala Met Lys Leu Glu Gln Glu Phe Thr Glu His Phe Thr Ala 
                725                 730                 735     


Ile Val Gln Gly Asp Thr Leu Glu Asp Ile Tyr Asn Gln Val Lys Gln 
            740                 745                 750         


Ile Ile Glu Glu Gln Ser Gly Ser Tyr Ile Trp Val Pro Ala Lys Glu 
        755                 760                 765             


Lys Leu 
    770 


