
                                SEQUENCE LISTING

<110> CytoDyn, Inc.

<120> ANTI-CD11A ANTIBODIES AND USES THEREOF

<130> 30583-0002WO1

<150> US 61/534,942
<151> 2011-09-15

<160> 22

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 113
<212> PRT
<213> Mus musculus

<400> 1
Asp Ile Val Ile Thr Gln Ser Thr Lys Phe Met Ser Thr Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Val Gln Ala
65                  70                  75                  80  
Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro
    


<210> 2
<211> 112
<212> PRT
<213> Mus musculus

<400> 2
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Tyr Ile Ser Ser Gly Ser Ser Thr Leu His Tyr Ala Asp Thr Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe
65                  70                  75                  80  
Leu Gln Met Lys Leu Pro Ser Leu Cys Tyr Gly Leu Leu Gly Ser Arg
                85                  90                  95      
Asn Leu Ser His Arg Leu Leu Ser Gln Asn Asp Thr Pro Ile Cys Leu
            100                 105                 110         


<210> 3
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Chimeric light chain

<400> 3
Asp Ile Val Ile Thr Gln Ser Thr Lys Phe Met Ser Thr Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Val Gln Ala
65                  70                  75                  80  
Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Phe Val Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 4
<211> 446
<212> PRT
<213> Artificial Sequence

<220> 
<223> Chimeric heavy chain

<400> 4
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Tyr Ile Ser Ser Gly Ser Ser Thr Leu His Tyr Ala Asp Thr Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe
65                  70                  75                  80  
Leu Gln Met Lys Leu Pro Ser Leu Cys Tyr Gly Leu Leu Gly Ser Arg
                85                  90                  95      
Asn Leu Ser His Arg Leu Leu Ser Gln Asn Asp Thr Pro Ile Cys Leu
            100                 105                 110         
Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala
        115                 120                 125             
Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu
    130                 135                 140                 
Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly
145                 150                 155                 160 
Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
                165                 170                 175     
Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu
            180                 185                 190         
Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr
        195                 200                 205             
Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr
    210                 215                 220                 
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
225                 230                 235                 240 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
                245                 250                 255     
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val
            260                 265                 270         
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
        275                 280                 285             
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val
    290                 295                 300                 
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
305                 310                 315                 320 
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser
                325                 330                 335     
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
            340                 345                 350         
Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
        355                 360                 365             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
    370                 375                 380                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp
385                 390                 395                 400 
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
                405                 410                 415     
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
            420                 425                 430         
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445     


<210> 5
<211> 230
<212> PRT
<213> Artificial Sequence

<220> 
<223> Chimeric light chain

<400> 5
Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu Val Thr Asn Ser
 1               5                  10                  15      
Asp Ile Val Ile Thr Gln Ser Thr Lys Phe Met Ser Thr Ser Val Gly
            20                  25                  30          
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala
        35                  40                  45              
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
    50                  55                  60                  
Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
65                  70                  75                  80  
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Val Gln Ala
                85                  90                  95      
Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Trp
            100                 105                 110         
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala
        115                 120                 125             
Pro Ser Phe Val Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
    130                 135                 140                 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
145                 150                 155                 160 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
                165                 170                 175     
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
            180                 185                 190         
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
        195                 200                 205             
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
    210                 215                 220                 
Phe Asn Arg Gly Glu Cys
225                 230 


<210> 6
<211> 4175
<212> DNA
<213> Artificial Sequence

<220> 
<223> Chimeric light chain

<400> 6
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg 60
agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa 120
actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt 180
atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac 240
agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc 300
gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg 360
cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc 420
cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac 480
tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc 540
ctacctgaga tcaacatgta caggatgcaa ctcctgtctt gcattgcact aagtcttgca 600
cttgtcacga attcagacat agttattacc caaagtacaa aattcatgtc tacatccgtg 660
ggtgaccggg tttcaatcac ctgtaaggcc agccaggatg tgtcaacagc agttgcttgg 720
taccagcaga agcctggaca gagccctaag ctcctgatat attgggcttc cacccggcat 780
acaggtgtcc cagataggtt cacaggctcc ggaagtggta ctgactacac actgactatc 840
agccgcgtgc aggcagaaga cctcgctctg tattattgtc agcagcatta tacaactccc 900
tggaccttcg gaggaggaac aaagctggag attaagcgta cggtggctgc accatctgtc 960
ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg 1020
ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa 1080
tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc 1140
agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa 1200
gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag 1260
agggagctag ctcgacatga taagatacat tgatgagttt ggacaaacca caactagaat 1320
gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtgaaatt 1380
tgtgatgcta ttgctttatt tgtaaccatt ataagctgca ataaacaagt taacaacaac 1440
aattgcattc attttatgtt tcaggttcag ggggaggtgt gggaggtttt ttaaagcaag 1500
taaaacctct acaaatgtgg tatggaatta attctaaaat acagcatagc aaaactttaa 1560
cctccaaatc aagcctctac ttgaatcctt ttctgaggga tgaataaggc ataggcatca 1620
ggggctgttg ccaatgtgca ttagctgttt gcagcctcac cttctttcat ggagtttaag 1680
atatagtgta ttttcccaag gtttgaacta gctcttcatt tctttatgtt ttaaatgcac 1740
tgacctccca cattcccttt ttagtaaaat attcagaaat aatttaaata catcattgca 1800
atgaaaataa atgtttttta ttaggcagaa tccagatgct caaggccctt cataatatcc 1860
cccagtttag tagttggact tagggaacaa aggaaccttt aatagaaatt ggacagcaag 1920
aaagcgagct tctagcttta gttcctggtg tacttgaggg ggatgagttc ctcaatggtg 1980
gttttgacca gcttgccatt catctcaatg agcacaaagc agtcaggagc atagtcagag 2040
atgagctctc tgcacatgcc acaggggctg accaccctga tggatctgtc cacctcatca 2100
gagtaggggt gcctgacagc cacaatggtg tcaaagtcct tctgcccgtt gctcacagca 2160
gacccaatgg caatggcttc agcacagaca gtgaccctgc caatgtaggc ctcaatgtgg 2220
acagcagaga tgatctcccc agtcttggtc ctgatggccg ccccgacatg gtgcttgttg 2280
tcctcataga gcatggtgat cttctcagtg gcgacctcca ccagctccag atcctgctga 2340
gagatgttga aggtcttcat gatggctcct cctgtcagga gaggaaagag aagaaggtta 2400
gtacaattgc tatagtgagt tgtattatac tatgcttatg attaattgtc aaactagggc 2460
tgcagggttc atagtgccac ttttcctgca ctgccccatc tcctgcccac cctttcccag 2520
gcatagacag tcagtgactt accaaactca caggagggag aaggcagaag cttgagacag 2580
acccgcggga ccgccgaact gcgaggggac gtggctaggg cggcttcttt tatggtgcgc 2640
cggccctcgg aggcagggcg ctcggggagg cctagcggcc aatctgcggt ggcaggaggc 2700
ggggccgaag gccgtgcctg accaatccgg agcacatagg agtctcagcc ccccgcccca 2760
aagcaagggg aagtcacgcg cctgtagcgc cagcgtgttg tgaaatgggg gcttgggggg 2820
gttggggccc tgactagtca aaacaaactc ccattgacgt caatggggtg gagacttgga 2880
aatccccgtg agtcaaaccg ctatccacgc ccattgatgt actgccaaaa ccgcatcatc 2940
atggtaatag cgatgactaa tacgtagatg tactgccaag taggaaagtc ccataaggtc 3000
atgtactggg cataatgcca ggcgggccat ttaccgtcat tgacgtcaat agggggcgta 3060
cttggcatat gatacacttg atgtactgcc aagtgggcag tttaccgtaa atactccacc 3120
cattgacgtc aatggaaagt ccctattggc gttactatgg gaacatacgt cattattgac 3180
gtcaatgggc gggggtcgtt gggcggtcag ccaggcgggc catttaccgt aagttatgta 3240
acgcctgcag gttaattaag aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta 3300
aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag catcacaaaa 3360
atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac caggcgtttc 3420
cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc ggatacctgt 3480
ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt aggtatctca 3540
gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc gttcagcccg 3600
accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga cacgacttat 3660
cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta ggcggtgcta 3720
cagagttctt gaagtggtgg cctaactacg gctacactag aagaacagta tttggtatct 3780
gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga tccggcaaac 3840
aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg cgcagaaaaa 3900
aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag tggaacgaaa 3960
actcacgtta agggattttg gtcatggcta gttaattaac atttaaatca gcggccgcaa 4020
taaaatatct ttattttcat tacatctgtg tgttggtttt ttgtgtgaat cgtaactaac 4080
atacgctctc catcaaaaca aaacgaaaca aaacaaacta gcaaaatagg ctgtccccag 4140
tgcaagtgca ggtgccagaa catttctcta tcgaa                            4175

<210> 7
<211> 4768
<212> DNA
<213> Artificial Sequence

<220> 
<223> Chimeric heavy chain

<400> 7
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg 60
agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa 120
actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt 180
atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac 240
agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc 300
gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg 360
cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc 420
cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac 480
tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc 540
ctacctgaga tcaccggtga attcactatg gaagttaagc tggaagaatc tggtggtggg 600
ctcgttcaac ccggaggaag caggaagctc tcctgcgctg catcaggctt taccttctcc 660
agtttcggaa tgcattgggt taggcaggct cccgagaagg gactggagtg ggtggcatac 720
attagtagcg gcagtagcac cctgcattac gcagacacag tcaagggccg gttcacaata 780
tcacgggata accctaagaa cacactgttt ctgcagatga agctgccctc tctctgttac 840
ggcctcctgg gcagccggaa tctgtcacat agactgctct cccagaacga tacacccatt 900
tgcctgacag ttagcagcgc tagcaccaag ggcccatcgg tcttccccct ggcaccctcc 960
tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc 1020
gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg 1080
gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc 1140
agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg 1200
gacaagaaag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca 1260
cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc 1320
atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct 1380
gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg 1440
cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag 1500
gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc 1560
atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg 1620
cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc 1680
ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac 1740
aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc 1800
gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct 1860
ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaatg agtcctagct 1920
ggccagacat gataagatac attgatgagt ttggacaaac cacaactaga atgcagtgaa 1980
aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct 2040
gcaataaaca agttaacaac aacaattgca ttcattttat gtttcaggtt cagggggagg 2100
tgtgggaggt tttttaaagc aagtaaaacc tctacaaatg tggtatggaa ttaattctaa 2160
aatacagcat agcaaaactt taacctccaa atcaagcctc tacttgaatc cttttctgag 2220
ggatgaataa ggcataggca tcaggggctg ttgccaatgt gcattagctg tttgcagcct 2280
caccttcttt catggagttt aagatatagt gtattttccc aaggtttgaa ctagctcttc 2340
atttctttat gttttaaatg cactgacctc ccacattccc tttttagtaa aatattcaga 2400
aataatttaa atacatcatt gcaatgaaaa taaatgtttt ttattaggca gaatccagat 2460
gctcaaggcc cttcataata tcccccagtt tagtagttgg acttagggaa caaaggaacc 2520
tttaatagaa attggacagc aagaaagcga gcttctagct tatcctcagt cctgctcctc 2580
tgccacaaag tgcacgcagt tgccggccgg gtcgcgcagg gcgaactccc gcccccacgg 2640
ctgctcgccg atctcggtca tggccggccc ggaggcgtcc cggaagttcg tggacacgac 2700
ctccgaccac tcggcgtaca gctcgtccag gccgcgcacc cacacccagg ccagggtgtt 2760
gtccggcacc acctggtcct ggaccgcgct gatgaacagg gtcacgtcgt cccggaccac 2820
accggcgaag tcgtcctcca cgaagtcccg ggagaacccg agccggtcgg tccagaactc 2880
gaccgctccg gcgacgtcgc gcgcggtgag caccggaacg gcactggtca acttggccat 2940
gatggctcct cctgtcagga gaggaaagag aagaaggtta gtacaattgc tatagtgagt 3000
tgtattatac tatgcagata tactatgcca atgattaatt gtcaaactag ggctgcaggg 3060
ttcatagtgc cacttttcct gcactgcccc atctcctgcc caccctttcc caggcataga 3120
cagtcagtga cttaccaaac tcacaggagg gagaaggcag aagcttgaga cagacccgcg 3180
ggaccgccga actgcgaggg gacgtggcta gggcggcttc ttttatggtg cgccggccct 3240
cggaggcagg gcgctcgggg aggcctagcg gccaatctgc ggtggcagga ggcggggccg 3300
aaggccgtgc ctgaccaatc cggagcacat aggagtctca gccccccgcc ccaaagcaag 3360
gggaagtcac gcgcctgtag cgccagcgtg ttgtgaaatg ggggcttggg ggggttgggg 3420
ccctgactag tcaaaacaaa ctcccattga cgtcaatggg gtggagactt ggaaatcccc 3480
gtgagtcaaa ccgctatcca cgcccattga tgtactgcca aaaccgcatc atcatggtaa 3540
tagcgatgac taatacgtag atgtactgcc aagtaggaaa gtcccataag gtcatgtact 3600
gggcataatg ccaggcgggc catttaccgt cattgacgtc aatagggggc gtacttggca 3660
tatgatacac ttgatgtact gccaagtggg cagtttaccg taaatactcc acccattgac 3720
gtcaatggaa agtccctatt ggcgttacta tgggaacata cgtcattatt gacgtcaatg 3780
ggcgggggtc gttgggcggt cagccaggcg ggccatttac cgtaagttat gtaacgcctg 3840
caggttaatt aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc 3900
cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg 3960
ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg 4020
aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt 4080
tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt 4140
gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg 4200
cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact 4260
ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt 4320
cttgaagtgg tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct 4380
gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac 4440
cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc 4500
tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg 4560
ttaagggatt ttggtcatgg ctagttaatt aacatttaaa tcagcggccg caataaaata 4620
tctttatttt cattacatct gtgtgttggt tttttgtgtg aatcgtaact aacatacgct 4680
ctccatcaaa acaaaacgaa acaaaacaaa ctagcaaaat aggctgtccc cagtgcaagt 4740
gcaggtgcca gaacatttct ctatcgaa                                    4768

<210> 8
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> Forward primer

<400> 8
atatcatatg tacaacctgg acgtgcgggg cgcgcgg                          37

<210> 9
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reverse primer

<400> 9
atatgcggcc gccatctgct tctcatacac cacgtcaacc                       40

<210> 10
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> Forward primer

<400> 10
atatcatatg tcccggcccg tggtggatat ggtcacc                          37

<210> 11
<211> 961
<212> PRT
<213> Homo sapiens

<400> 11
Phe Gly Tyr Arg Val Leu Gln Val Gly Asn Gly Val Ile Val Gly Ala
 1               5                  10                  15      
Pro Gly Glu Gly Asn Ser Thr Gly Ser Leu Tyr Gln Cys Gln Ser Gly
            20                  25                  30          
Thr Gly His Cys Leu Pro Val Thr Leu Arg Gly Ser Asn Tyr Thr Ser
        35                  40                  45              
Lys Tyr Leu Gly Met Thr Leu Ala Thr Asp Pro Thr Asp Gly Ser Ile
    50                  55                  60                  
Leu Phe Ala Ala Val Gln Phe Ser Thr Ser Tyr Lys Thr Glu Phe Asp
65                  70                  75                  80  
Phe Ser Asp Tyr Val Lys Arg Lys Asp Pro Asp Ala Leu Leu Lys His
                85                  90                  95      
Val Lys His Met Leu Leu Leu Thr Asn Thr Phe Gly Ala Ile Asn Tyr
            100                 105                 110         
Val Ala Thr Glu Val Phe Arg Glu Glu Leu Gly Ala Arg Pro Asp Ala
        115                 120                 125             
Thr Lys Val Leu Ile Ile Ile Thr Asp Gly Glu Ala Thr Asp Ser Gly
    130                 135                 140                 
Asn Ile Asp Ala Ala Lys Asp Ile Ile Arg Tyr Ile Ile Gly Ile Gly
145                 150                 155                 160 
Lys His Phe Gln Thr Lys Glu Ser Gln Glu Thr Leu His Lys Phe Ala
                165                 170                 175     
Ser Lys Pro Ala Ser Glu Phe Val Lys Ile Leu Asp Thr Phe Glu Lys
            180                 185                 190         
Leu Lys Asp Leu Phe Thr Glu Leu Gln Lys Lys Ile Tyr Val Ile Glu
        195                 200                 205             
Gly Thr Ser Lys Gln Asp Leu Thr Ser Phe Asn Met Glu Leu Ser Ser
    210                 215                 220                 
Ser Gly Ile Ser Ala Asp Leu Ser Arg Gly His Ala Val Val Gly Ala
225                 230                 235                 240 
Val Gly Ala Lys Asp Trp Ala Gly Gly Phe Leu Asp Leu Lys Ala Asp
                245                 250                 255     
Leu Gln Asp Asp Thr Phe Ile Gly Asn Glu Pro Leu Thr Pro Glu Val
            260                 265                 270         
Arg Ala Gly Tyr Leu Gly Tyr Thr Val Thr Trp Leu Pro Ser Arg Gln
        275                 280                 285             
Lys Thr Ser Leu Leu Ala Ser Gly Ala Pro Arg Tyr Gln His Met Gly
    290                 295                 300                 
Arg Val Leu Leu Phe Gln Glu Pro Gln Gly Gly Gly His Trp Ser Gln
305                 310                 315                 320 
Val Gln Thr Ile His Gly Thr Gln Ile Gly Ser Tyr Phe Gly Gly Glu
                325                 330                 335     
Leu Cys Gly Val Asp Val Asp Gln Asp Gly Glu Thr Glu Leu Leu Leu
            340                 345                 350         
Ile Gly Ala Pro Leu Phe Tyr Gly Glu Gln Arg Gly Gly Arg Val Phe
        355                 360                 365             
Ile Tyr Gln Arg Arg Gln Leu Gly Phe Glu Glu Val Ser Glu Leu Gln
    370                 375                 380                 
Gly Asp Pro Gly Tyr Pro Leu Gly Arg Phe Gly Glu Ala Ile Thr Ala
385                 390                 395                 400 
Leu Thr Asp Ile Asn Gly Asp Gly Leu Val Asp Val Ala Val Gly Ala
                405                 410                 415     
Pro Leu Glu Glu Gln Gly Ala Val Tyr Ile Phe Asn Gly Arg His Gly
            420                 425                 430         
Gly Leu Ser Pro Gln Pro Ser Gln Arg Ile Glu Gly Thr Gln Val Leu
        435                 440                 445             
Ser Gly Ile Gln Trp Phe Gly Arg Ser Ile His Gly Val Lys Asp Leu
    450                 455                 460                 
Glu Gly Asp Gly Leu Ala Asp Val Ala Val Gly Ala Glu Ser Gln Met
465                 470                 475                 480 
Ile Val Leu Ser Ser Arg Pro Val Val Asp Met Val Thr Leu Met Ser
                485                 490                 495     
Phe Ser Pro Ala Glu Ile Pro Val His Glu Val Glu Cys Ser Tyr Ser
            500                 505                 510         
Thr Ser Asn Lys Met Lys Glu Gly Val Asn Ile Thr Ile Cys Phe Gln
        515                 520                 525             
Ile Lys Ser Leu Ile Pro Gln Phe Gln Gly Arg Leu Val Ala Asn Leu
    530                 535                 540                 
Thr Tyr Thr Leu Gln Leu Asp Gly His Arg Thr Arg Arg Arg Gly Leu
545                 550                 555                 560 
Phe Pro Gly Gly Arg His Glu Leu Arg Arg Asn Ile Ala Val Thr Thr
                565                 570                 575     
Ser Met Ser Cys Thr Asp Phe Ser Phe His Phe Pro Val Cys Val Gln
            580                 585                 590         
Asp Leu Ile Ser Pro Ile Asn Val Ser Leu Asn Phe Ser Leu Trp Glu
        595                 600                 605             
Glu Glu Gly Thr Pro Arg Asp Gln Arg Ala Gly Lys Asp Ile Pro Pro
    610                 615                 620                 
Ile Leu Arg Pro Ser Leu His Ser Glu Thr Trp Glu Ile Pro Phe Glu
625                 630                 635                 640 
Lys Asn Cys Gly Glu Asp Lys Lys Cys Glu Ala Asn Leu Arg Val Ser
                645                 650                 655     
Phe Ser Pro Ala Arg Ser Arg Ala Leu Arg Leu Thr Ala Phe Ala Ser
            660                 665                 670         
Leu Ser Val Glu Leu Ser Leu Ser Asn Leu Glu Glu Asp Ala Tyr Trp
        675                 680                 685             
Val Gln Leu Asp Leu His Phe Pro Pro Gly Leu Ser Phe Arg Lys Val
    690                 695                 700                 
Glu Met Leu Lys Pro His Ser Gln Ile Pro Val Ser Cys Glu Glu Leu
705                 710                 715                 720 
Pro Glu Glu Ser Arg Leu Leu Ser Arg Ala Leu Ser Cys Asn Val Ser
                725                 730                 735     
Ser Pro Ile Phe Lys Ala Gly His Ser Val Ala Leu Gln Met Met Phe
            740                 745                 750         
Asn Thr Leu Val Asn Ser Ser Trp Gly Asp Ser Val Glu Leu His Ala
        755                 760                 765             
Asn Val Thr Cys Asn Asn Glu Asp Ser Asp Leu Leu Glu Asp Asn Ser
    770                 775                 780                 
Ala Thr Thr Ile Ile Pro Ile Leu Tyr Pro Ile Asn Ile Leu Ile Gln
785                 790                 795                 800 
Asp Gln Glu Asp Ser Thr Leu Tyr Val Ser Phe Thr Pro Lys Gly Pro
                805                 810                 815     
Lys Ile His Gln Val Lys His Met Tyr Gln Val Arg Ile Gln Pro Ser
            820                 825                 830         
Ile His Asp His Asn Ile Pro Thr Leu Glu Ala Val Val Gly Val Pro
        835                 840                 845             
Gln Pro Pro Ser Glu Gly Pro Ile Thr His Gln Trp Ser Val Gln Met
    850                 855                 860                 
Glu Pro Pro Val Pro Cys His Tyr Glu Asp Leu Glu Arg Leu Pro Asp
865                 870                 875                 880 
Ala Ala Glu Pro Cys Leu Pro Gly Ala Leu Phe Arg Cys Pro Val Val
                885                 890                 895     
Phe Arg Gln Glu Ile Leu Val Gln Val Ile Gly Thr Leu Glu Leu Val
            900                 905                 910         
Gly Glu Ile Glu Ala Ser Ser Met Phe Ser Leu Cys Ser Ser Leu Ser
        915                 920                 925             
Ile Ser Phe Asn Ser Ser Lys His Phe His Leu Tyr Gly Ser Asn Ala
    930                 935                 940                 
Ser Leu Ala Gln Val Val Met Lys Val Asp Val Val Tyr Glu Lys Gln
945                 950                 955                 960 
Met
    


<210> 12
<211> 476
<212> PRT
<213> Homo sapiens

<400> 12
Arg Pro Val Val Asp Met Val Thr Leu Met Ser Phe Ser Pro Ala Glu
 1               5                  10                  15      
Ile Pro Val His Glu Val Glu Cys Ser Tyr Ser Thr Ser Asn Lys Met
            20                  25                  30          
Lys Glu Gly Val Asn Ile Thr Ile Cys Phe Gln Ile Lys Ser Leu Ile
        35                  40                  45              
Pro Gln Phe Gln Gly Arg Leu Val Ala Asn Leu Thr Tyr Thr Leu Gln
    50                  55                  60                  
Leu Asp Gly His Arg Thr Arg Arg Arg Gly Leu Phe Pro Gly Gly Arg
65                  70                  75                  80  
His Glu Leu Arg Arg Asn Ile Ala Val Thr Thr Ser Met Ser Cys Thr
                85                  90                  95      
Asp Phe Ser Phe His Phe Pro Val Cys Val Gln Asp Leu Ile Ser Pro
            100                 105                 110         
Ile Asn Val Ser Leu Asn Phe Ser Leu Trp Glu Glu Glu Gly Thr Pro
        115                 120                 125             
Arg Asp Gln Arg Ala Gly Lys Asp Ile Pro Pro Ile Leu Arg Pro Ser
    130                 135                 140                 
Leu His Ser Glu Thr Trp Glu Ile Pro Phe Glu Lys Asn Cys Gly Glu
145                 150                 155                 160 
Asp Lys Lys Cys Glu Ala Asn Leu Arg Val Ser Phe Ser Pro Ala Arg
                165                 170                 175     
Ser Arg Ala Leu Arg Leu Thr Ala Phe Ala Ser Leu Ser Val Glu Leu
            180                 185                 190         
Ser Leu Ser Asn Leu Glu Glu Asp Ala Tyr Trp Val Gln Leu Asp Leu
        195                 200                 205             
His Phe Pro Pro Gly Leu Ser Phe Arg Lys Val Glu Met Leu Lys Pro
    210                 215                 220                 
His Ser Gln Ile Pro Val Ser Cys Glu Glu Leu Pro Glu Glu Ser Arg
225                 230                 235                 240 
Leu Leu Ser Arg Ala Leu Ser Cys Asn Val Ser Ser Pro Ile Phe Lys
                245                 250                 255     
Ala Gly His Ser Val Ala Leu Gln Met Met Phe Asn Thr Leu Val Asn
            260                 265                 270         
Ser Ser Trp Gly Asp Ser Val Glu Leu His Ala Asn Val Thr Cys Asn
        275                 280                 285             
Asn Glu Asp Ser Asp Leu Leu Glu Asp Asn Ser Ala Thr Thr Ile Ile
    290                 295                 300                 
Pro Ile Leu Tyr Pro Ile Asn Ile Leu Ile Gln Asp Gln Glu Asp Ser
305                 310                 315                 320 
Thr Leu Tyr Val Ser Phe Thr Pro Lys Gly Pro Lys Ile His Gln Val
                325                 330                 335     
Lys His Met Tyr Gln Val Arg Ile Gln Pro Ser Ile His Asp His Asn
            340                 345                 350         
Ile Pro Thr Leu Glu Ala Val Val Gly Val Pro Gln Pro Pro Ser Glu
        355                 360                 365             
Gly Pro Ile Thr His Gln Trp Ser Val Gln Met Glu Pro Pro Val Pro
    370                 375                 380                 
Cys His Tyr Glu Asp Leu Glu Arg Leu Pro Asp Ala Ala Glu Pro Cys
385                 390                 395                 400 
Leu Pro Gly Ala Leu Phe Arg Cys Pro Val Val Phe Arg Gln Glu Ile
                405                 410                 415     
Leu Val Gln Val Ile Gly Thr Leu Glu Leu Val Gly Glu Ile Glu Ala
            420                 425                 430         
Ser Ser Met Phe Ser Leu Cys Ser Ser Leu Ser Ile Ser Phe Asn Ser
        435                 440                 445             
Ser Lys His Phe His Leu Tyr Gly Ser Asn Ala Ser Leu Ala Gln Val
    450                 455                 460                 
Val Met Lys Val Asp Val Val Tyr Glu Lys Gln Met
465                 470                 475     


<210> 13
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Complementary Determining Region

<400> 13
Ser Phe Gly Met His
 1               5  


<210> 14
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Complementary Determining Region

<400> 14
Tyr Ile Ser Ser Gly Ser Ser Thr Leu His Tyr Ala Asp Thr Val Lys
 1               5                  10                  15      
Gly
    


<210> 15
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Complementary Determining Region

<400> 15
Gly Ser Arg Asn Leu Ser His Arg Leu Leu Ser
 1               5                  10      


<210> 16
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Complementary Determining Region

<400> 16
Lys Ala Ser Gln Asp Val Ser Thr Ala Val Ala
 1               5                  10      


<210> 17
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Complementary Determining Region

<400> 17
Trp Ala Ser Thr Arg His Thr
 1               5          


<210> 18
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Complementary Determining Region

<400> 18
Gln Gln His Tyr Thr Thr Pro Trp Thr
 1               5                  


<210> 19
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Chimeric light chain variable domain

<400> 19
Asp Ile Val Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 20
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Chimeric light chain variable domain

<400> 20
Asp Ile Leu Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Thr Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln Ala
65                  70                  75                  80  
Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 21
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> Chimeric heavy chain variable domain

<400> 21
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Ser Ser Gly Ser Ser Thr Leu His Tyr Ala Asp Thr Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Ser Arg Asn Leu Ser His Arg Leu Leu Ser Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120     


<210> 22
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> Chimeric heavy chain variable domain

<400> 22
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Tyr Ile Ser Ser Gly Ser Ser Thr Leu His Tyr Ala Asp Thr Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Leu Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Ser Arg Asn Leu Ser His Arg Leu Leu Ser Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120     

