                         SEQUENCE LISTING

<110>  Eli Lilly and Company
 
<120>  Antibodies to PCSK9 and Uses Thereof

<130>  X19477

<150>  61/535625
<151>  2011-09-16

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Gly Phe Pro Phe Ser Lys Leu Gly Met Val 
1               5                   10  


<210>  2
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2

Thr Ile Ser Ser Gly Gly Gly Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3

Glu Gly Ile Ser Phe Gln Gly Gly Thr Tyr Thr Tyr Val Met Asp Tyr 
1               5                   10                  15      


<210>  4
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  4

Arg Ser Ser Lys Ser Leu Leu His Arg Asn Gly Ile Thr Tyr Ser Tyr 
1               5                   10                  15      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  5

Gln Leu Ser Asn Leu Ala Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  6

Tyr Gln Asn Leu Glu Leu Pro Leu Thr 
1               5                   


<210>  7
<211>  125
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Ser Lys Leu 
            20                  25                  30          


Gly Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Gly Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Ile Ser Phe Gln Gly Gly Thr Tyr Thr Tyr Val Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  8
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  8

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Arg 
            20                  25                  30          


Asn Gly Ile Thr Tyr Ser Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Leu Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Tyr Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  9
<211>  451
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Ser Lys Leu 
            20                  25                  30          


Gly Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Gly Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Ile Ser Phe Gln Gly Gly Thr Tyr Thr Tyr Val Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    130                 135                 140                 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
        195                 200                 205             


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Leu Gly 
    450     


<210>  10
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  10

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Arg 
            20                  25                  30          


Asn Gly Ile Thr Tyr Ser Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Leu Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Tyr Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  11
<211>  1356
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  11
gaggtgcagc tggtggagtc tgggggaggc ttggtaaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cccgttcagt aagctcggca tggtttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gtggtggtta cacatactat      180

ccagacagtg tgaaggggcg gttcaccatc tccagagaca atgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gagagaagga      300

attagctttc agggtggcac ctacacttat gttatggact actggggcca gggcaccctg      360

gtcaccgtct cctcagcctc caccaagggc ccatcggtct tcccgctagc gccctgctcc      420

aggagcacct ccgagagcac agccgccctg ggctgcctgg tcaaggacta cttccccgaa      480

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600

ttgggcacga agacctacac ctgcaacgta gatcacaagc ccagcaacac caaggtggac      660

aagagagttg agtccaaata tggtccccca tgcccaccct gcccagcacc tgaggccgcc      720

gggggaccat cagtcttcct gttcccccca aaacccaagg acactctcat gatctcccgg      780

acccctgagg tcacgtgcgt ggtggtggac gtgagccagg aagaccccga ggtccagttc      840

aactggtacg tggatggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      900

ttcaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaac      960

ggcaaggagt acaagtgcaa ggtctccaac aaaggcctcc cgtcctccat cgagaaaacc     1020

atctccaaag ccaaagggca gccccgagag ccacaggtgt acaccctgcc cccatcccag     1080

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctaccccagc     1140

gacatcgccg tggagtggga aagcaatggg cagccggaga acaactacaa gaccacgcct     1200

cccgtgctgg actccgacgg ctccttcttc ctctacagca ggctaaccgt ggacaagagc     1260

aggtggcagg aggggaatgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1320

tacacacaga agagcctctc cctgtctctg ggttga                               1356


<210>  12
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  12
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtaa gagtctctta catcgtaatg gcatcactta ttcgtattgg      120

tacctgcaga agccagggca gtctccacag ctcctgatct atcagctgtc caaccttgcc      180

tcaggagtcc cagacaggtt cagtggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggagtt tattactgct atcaaaatct agaacttccg      300

ctcacgttcg gccagggcac caaggtggaa atcaaacgga ctgtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgctaa      660


<210>  13
<211>  672
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  13

Arg Ala Gln Glu Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala 
1               5                   10                  15      


Leu Arg Ser Glu Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr 
            20                  25                  30          


Thr Ala Thr Phe His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly 
        35                  40                  45              


Thr Tyr Val Val Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu 
    50                  55                  60                  


Arg Thr Ala Arg Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu 
65                  70                  75                  80  


Thr Lys Ile Leu His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val 
                85                  90                  95      


Lys Met Ser Gly Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val 
            100                 105                 110         


Asp Tyr Ile Glu Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp 
        115                 120                 125             


Asn Leu Glu Arg Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln 
    130                 135                 140                 


Pro Pro Asp Gly Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser 
145                 150                 155                 160 


Ile Gln Ser Asp His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp 
                165                 170                 175     


Phe Glu Asn Val Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala 
            180                 185                 190         


Ser Lys Cys Asp Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly 
        195                 200                 205             


Arg Asp Ala Gly Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val 
    210                 215                 220                 


Leu Asn Cys Gln Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu 
225                 230                 235                 240 


Glu Phe Ile Arg Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val 
                245                 250                 255     


Val Leu Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala 
            260                 265                 270         


Cys Gln Arg Leu Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly 
        275                 280                 285             


Asn Phe Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu 
    290                 295                 300                 


Val Ile Thr Val Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu 
305                 310                 315                 320 


Gly Thr Leu Gly Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro 
                325                 330                 335     


Gly Glu Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val 
            340                 345                 350         


Ser Gln Ser Gly Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala 
        355                 360                 365             


Ala Met Met Leu Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg 
    370                 375                 380                 


Gln Arg Leu Ile His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp 
385                 390                 395                 400 


Phe Pro Glu Asp Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu 
                405                 410                 415     


Pro Pro Ser Thr His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val 
            420                 425                 430         


Trp Ser Ala His Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg 
        435                 440                 445             


Cys Ala Pro Asp Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser 
    450                 455                 460                 


Gly Lys Arg Arg Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val 
465                 470                 475                 480 


Cys Arg Ala His Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala 
                485                 490                 495     


Arg Cys Cys Leu Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro 
            500                 505                 510         


Pro Ala Glu Ala Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly 
        515                 520                 525             


His Val Leu Thr Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly 
    530                 535                 540                 


Thr His Lys Pro Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys 
545                 550                 555                 560 


Val Gly His Arg Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro 
                565                 570                 575     


Gly Leu Glu Cys Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu 
            580                 585                 590         


Gln Val Thr Val Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser 
        595                 600                 605             


Ala Leu Pro Gly Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn 
    610                 615                 620                 


Thr Cys Val Val Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser 
625                 630                 635                 640 


Glu Gly Ala Val Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu 
                645                 650                 655     


Ala Gln Ala Ser Gln Glu Leu Gln Asp Val His His His His His His 
            660                 665                 670         


<210>  14
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  14

Arg Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp 
1               5                   10                  15      


Gly Gly Ser Leu Val Glu 
            20          


<210>  15
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  15

Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly Gly Ser Leu Val Glu 
1               5                   10                  15      


<210>  16
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  16

Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro 
1               5                   10          


<210>  17
<211>  376
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  17

Gln Glu Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg 
1               5                   10                  15      


Ser Glu Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala 
            20                  25                  30          


Thr Phe His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr 
        35                  40                  45              


Val Val Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr 
    50                  55                  60                  


Ala Arg Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys 
65                  70                  75                  80  


Ile Leu His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met 
                85                  90                  95      


Ser Gly Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr 
            100                 105                 110         


Ile Glu Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu 
        115                 120                 125             


Glu Arg Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro 
    130                 135                 140                 


Asp Gly Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln 
145                 150                 155                 160 


Ser Asp His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu 
                165                 170                 175     


Asn Val Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys 
            180                 185                 190         


Cys Asp Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp 
        195                 200                 205             


Ala Gly Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn 
    210                 215                 220                 


Cys Gln Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe 
225                 230                 235                 240 


Ile Arg Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu 
                245                 250                 255     


Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln 
            260                 265                 270         


Arg Leu Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe 
        275                 280                 285             


Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile 
    290                 295                 300                 


Thr Val Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr 
305                 310                 315                 320 


Leu Gly Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu 
                325                 330                 335     


Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln 
            340                 345                 350         


Ser Gly Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met 
        355                 360                 365             


Met Leu Ser Ala Glu Pro Glu Leu 
    370                 375     


