﻿SEQUENCE LISTING

<110>   NOVARTIS AG

<120>   ESCHERICHIA COLI VACCINE COMBINATION

<130>   P057530WO

<140>   PCT/IB2012/______
<141>   2012-09-14

<150>   GB-1115906.8 
<151>   2011-09-14

<150>   GB-1213251.0 
<151>   2012-07-25

<160>   57

<170>   SeqWin2010, version 1.0

<210>   1
<211>   1242
<212>   DNA
<213>   Escherichia coli

<400>   1
gttgctgatg gtcagcaagc ctacacgctg acactgacag cggtggactc cgagggtaat  60
ccggtgacgg gagaagccag ccgcctgcga cttgttccgc aagacactaa tggtgtaacc  120
gttggtgcca tttcggaaat aaaaccaggg gtttacagcg ccacggtttc ttcgacccgt  180
gccggaaacg ttgttgtgcg tgccttcagc gagcagtatc agctgggcac attacaacaa  240
acgctgaagt ttgttgccgg gccgcttgat gcagcacatt cgtccatcac actgaatcct  300
gataaaccgg tggttggcgg tacagttacg gcaatctgga cggcaaaaga tgctaatgac  360
aaccctgtaa ctggcctcaa tccggatgca ccgtcattat cgggcgcagc tgctgctggt  420
tctacggcat caggctggac ggataatggc gacgggacct ggactgcgca gatttctctc  480
ggcactacgg cgggtgaatt agacgttatg ccgaagctca atgggcagga cgcggcagca  540
aatgcggcaa aagtaaccgt ggtggctgat gcattatctt caaaccagtc gaaagtctct  600
gtcgcagaag atcacgtaaa agccggtgaa agcacaaccg taacgctggt ggcgaaagat  660
gcgcatggca acgctatcag tggtctttcg ttgtcggcaa gtttgacggg gaccgcctct  720
gaaggggcga ccgtttccag ttggaccgaa aaaggtgacg gttcctatgt tgctacgtta  780
actacaggcg gaaagacggg cgagcttcgt gtcatgccgc tcttcaacgg ccagcctgca  840
gccaccgaag ccgcgcagct gactgttatt gccggagaga tgtcatcagc gaactctacg  900
cttgttgcgg acaataaaac tccaacggtt aaaacgacga cggaactcac cttcaccatg  960
aaggatgcgt acgggaatcc ggtcaccggg ctgaagccag atgcaccagt gtttagtggt  1020
gccgccagca cggggagtga gcgtccttca gcaggaaact ggacagagaa aggtaatggg  1080
gtctacgtgt cgaccttaac gctgggatct gccgcgggtc agttgtctgt gatgccgcga  1140
gtgaacggcc aaaatgccgt tgctcagcca ctggtgctga atgttgcagg tgacgcatct  1200
aaggctgaga ttcgtgatat gacagtgaag gttaataacc aa                     1242

<210>   2
<211>   414
<212>   PRT
<213>   Escherichia coli

<400>   2
Val Ala Asp Gly Gln Gln Ala Tyr Thr Leu Thr Leu Thr Ala Val Asp 
1               5                   10                  15      

Ser Glu Gly Asn Pro Val Thr Gly Glu Ala Ser Arg Leu Arg Leu Val 
            20                  25                  30          

Pro Gln Asp Thr Asn Gly Val Thr Val Gly Ala Ile Ser Glu Ile Lys 
        35                  40                  45              

Pro Gly Val Tyr Ser Ala Thr Val Ser Ser Thr Arg Ala Gly Asn Val 
    50                  55                  60                  

Val Val Arg Ala Phe Ser Glu Gln Tyr Gln Leu Gly Thr Leu Gln Gln 
65                  70                  75                  80  

Thr Leu Lys Phe Val Ala Gly Pro Leu Asp Ala Ala His Ser Ser Ile 
                85                  90                  95      

Thr Leu Asn Pro Asp Lys Pro Val Val Gly Gly Thr Val Thr Ala Ile 
            100                 105                 110         

Trp Thr Ala Lys Asp Ala Asn Asp Asn Pro Val Thr Gly Leu Asn Pro 
        115                 120                 125             

Asp Ala Pro Ser Leu Ser Gly Ala Ala Ala Ala Gly Ser Thr Ala Ser 
    130                 135                 140                 

Gly Trp Thr Asp Asn Gly Asp Gly Thr Trp Thr Ala Gln Ile Ser Leu 
145                 150                 155                 160 

Gly Thr Thr Ala Gly Glu Leu Asp Val Met Pro Lys Leu Asn Gly Gln 
                165                 170                 175     

Asp Ala Ala Ala Asn Ala Ala Lys Val Thr Val Val Ala Asp Ala Leu 
            180                 185                 190         

Ser Ser Asn Gln Ser Lys Val Ser Val Ala Glu Asp His Val Lys Ala 
        195                 200                 205             

Gly Glu Ser Thr Thr Val Thr Leu Val Ala Lys Asp Ala His Gly Asn 
    210                 215                 220                 

Ala Ile Ser Gly Leu Ser Leu Ser Ala Ser Leu Thr Gly Thr Ala Ser 
225                 230                 235                 240 

Glu Gly Ala Thr Val Ser Ser Trp Thr Glu Lys Gly Asp Gly Ser Tyr 
                245                 250                 255     

Val Ala Thr Leu Thr Thr Gly Gly Lys Thr Gly Glu Leu Arg Val Met 
            260                 265                 270         

Pro Leu Phe Asn Gly Gln Pro Ala Ala Thr Glu Ala Ala Gln Leu Thr 
        275                 280                 285             

Val Ile Ala Gly Glu Met Ser Ser Ala Asn Ser Thr Leu Val Ala Asp 
    290                 295                 300                 

Asn Lys Thr Pro Thr Val Lys Thr Thr Thr Glu Leu Thr Phe Thr Met 
305                 310                 315                 320 

Lys Asp Ala Tyr Gly Asn Pro Val Thr Gly Leu Lys Pro Asp Ala Pro 
                325                 330                 335     

Val Phe Ser Gly Ala Ala Ser Thr Gly Ser Glu Arg Pro Ser Ala Gly 
            340                 345                 350         

Asn Trp Thr Glu Lys Gly Asn Gly Val Tyr Val Ser Thr Leu Thr Leu 
        355                 360                 365             

Gly Ser Ala Ala Gly Gln Leu Ser Val Met Pro Arg Val Asn Gly Gln 
    370                 375                 380                 

Asn Ala Val Ala Gln Pro Leu Val Leu Asn Val Ala Gly Asp Ala Ser 
385                 390                 395                 400 

Lys Ala Glu Ile Arg Asp Met Thr Val Lys Val Asn Asn Gln 
                405                 410                 

<210>   3
<211>   453
<212>   DNA
<213>   Escherichia coli

<400>   3
atgattcacc tgttcaaaac ctgcatgatt accgccttca ttctggggtt aacgtggtct  60
gccccactcc gggcacagga tcaacgttac atcagtatac gcaatacaga tacgatatgg  120
ctcccgggaa atatttgtgc ttaccagttc cggctggata atggcggaaa cgatgaagga  180
tttggccccc tcaccatcac tctgcaactc aaagacaaat atggtcagac gctggtgacc  240
agaaaaatgg aaacggaagc ctttggtgac agtaatgcca cgcgaaccac agacgcattt  300
ctggaaacgg agtgcgtgga aaatgtcgcc acaaccgaaa tcattaaagc aactgaagaa  360
agtaacggcc atcgtgtcag tctgccgtta tcggttttcg atccccagga ctaccatcca  420
ctgctgatta ccgtttccgg aaaaaacgtt aac                               453

<210>   4
<211>   151
<212>   PRT
<213>   Escherichia coli

<400>   4
Met Ile His Leu Phe Lys Thr Cys Met Ile Thr Ala Phe Ile Leu Gly 
1               5                   10                  15      

Leu Thr Trp Ser Ala Pro Leu Arg Ala Gln Asp Gln Arg Tyr Ile Ser 
            20                  25                  30          

Ile Arg Asn Thr Asp Thr Ile Trp Leu Pro Gly Asn Ile Cys Ala Tyr 
        35                  40                  45              

Gln Phe Arg Leu Asp Asn Gly Gly Asn Asp Glu Gly Phe Gly Pro Leu 
    50                  55                  60                  

Thr Ile Thr Leu Gln Leu Lys Asp Lys Tyr Gly Gln Thr Leu Val Thr 
65                  70                  75                  80  

Arg Lys Met Glu Thr Glu Ala Phe Gly Asp Ser Asn Ala Thr Arg Thr 
                85                  90                  95      

Thr Asp Ala Phe Leu Glu Thr Glu Cys Val Glu Asn Val Ala Thr Thr 
            100                 105                 110         

Glu Ile Ile Lys Ala Thr Glu Glu Ser Asn Gly His Arg Val Ser Leu 
        115                 120                 125             

Pro Leu Ser Val Phe Asp Pro Gln Asp Tyr His Pro Leu Leu Ile Thr 
    130                 135                 140                 

Val Ser Gly Lys Asn Val Asn 
145                 150     

<210>   5
<211>   378
<212>   DNA
<213>   Escherichia coli

<400>   5
caggatcaac gttacatcag tatacgcaat acagatacga tatggctccc gggaaatatt  60
tgtgcttacc agttccggct ggataatggc ggaaacgatg aaggatttgg ccccctcacc  120
atcactctgc aactcaaaga caaatatggt cagacgctgg tgaccagaaa aatggaaacg  180
gaagcctttg gtgacagtaa tgccacgcga accacagacg catttctgga aacggagtgc  240
gtggaaaatg tcgccacaac cgaaatcatt aaagcaactg aagaaagtaa cggccatcgt  300
gtcagtctgc cgttatcggt tttcgatccc caggactacc atccactgct gattaccgtt  360
tccggaaaaa acgttaac                                                378

<210>   6
<211>   126
<212>   PRT
<213>   Escherichia coli

<400>   6
Gln Asp Gln Arg Tyr Ile Ser Ile Arg Asn Thr Asp Thr Ile Trp Leu 
1               5                   10                  15      

Pro Gly Asn Ile Cys Ala Tyr Gln Phe Arg Leu Asp Asn Gly Gly Asn 
            20                  25                  30          

Asp Glu Gly Phe Gly Pro Leu Thr Ile Thr Leu Gln Leu Lys Asp Lys 
        35                  40                  45              

Tyr Gly Gln Thr Leu Val Thr Arg Lys Met Glu Thr Glu Ala Phe Gly 
    50                  55                  60                  

Asp Ser Asn Ala Thr Arg Thr Thr Asp Ala Phe Leu Glu Thr Glu Cys 
65                  70                  75                  80  

Val Glu Asn Val Ala Thr Thr Glu Ile Ile Lys Ala Thr Glu Glu Ser 
                85                  90                  95      

Asn Gly His Arg Val Ser Leu Pro Leu Ser Val Phe Asp Pro Gln Asp 
            100                 105                 110         

Tyr His Pro Leu Leu Ile Thr Val Ser Gly Lys Asn Val Asn 
        115                 120                 125     

<210>   7
<211>   4560
<212>   DNA
<213>   Escherichia coli

<400>   7
atgaataaga aatttaaata taagaaatcg cttttagcgg ctattttaag cgcaaccctg  60
ttagccggtt gtgatggtgg tggttcagga tcgtcctccg atacgccgtc tgtagattct  120
ggatcaggga ctttgccgga agtgaaaccc gatccaacac caaccccgga gccgacacct  180
gagccgacgc cggacccaga acctacgccg gatccaacac ctgatcctga gccgacacca  240
gaaccggagc cagaacctgt tcctacgaaa acgggttatc tgaccctggg cggaagccag  300
cgggtaactg gtgctacctg taatggtgaa tccagcgatg gctttacctt tacgccaggc  360
aataccgtga gttgtgtggt gggcagtacg accattgcaa cattcaacac ccagtcagaa  420
gctgcgcgta gcctgcgtgc ggttgacaaa gtgtcgttta gcctggagga cgcgcaggag  480
ctggcgaatt ctgaaaataa gaaaaccaac gccatctctc tggtgacgtc cagcgacagt  540
tgccccgcag atgcagaaca gctttgtctt actttctcgt cagtggttga tcgcgcgcga  600
tttgaaaaac tgtataagca aattgatctg gcaacagaca atttcagcaa gctggtcaat  660
gaagaggtgg aaaacaatgc tgcgactgat aaagcgccgt ccacccatac ctcaacggta  720
gtgccagtca cgacagaggg aacaaaaccg gatctgaacg cgtccttcgt gtcggctaac  780
gcggaacagt tttatcagta tcaacccact gaaatcattc tttccgaagg ccaactggtg  840
gatagcctgg ggaacggtgt tgctggcgtt gactactaca ccaattcagg ccgtggcgta  900
actgacgaaa acggtaaatt ttcctttagc tggggcgaaa ccatctcctt tggtatcgat  960
acctttgaac tgggctcagt acgtggcaat aagtcgacca ttgcgctgac tgaattgggt  1020
gatgaagttc gcggggcaaa tatcgatcag ctcattcatc gttattcgac gactggtcaa  1080
aataatactc gtgttgttcc ggacgatgta cgcaaggtct ttgccgaata tcccaacgtg  1140
atcaacgaga taatcaatct ttcgttatcc aacggtgcga cgctggatga aggcgatcaa  1200
aacgttgtgc tgcctaacga atttatcgag cagtttaaga cgggtcaggc caaagagatc  1260
gataccgcga tttgtgcgaa aaccgacggt tgtaacgagg ctcgctggtt ctcgctgaca  1320
acgcgcaatg ttaatgacgg ccagattcag ggcgttatta acaagctgtg gggcgtggat  1380
acgaactatc agtctgtcag caagttccac gtcttccatg actctaccaa cttctatggc  1440
agcaccggta acgcgcgcgg tcaggcggtg gtaaatatct ccaactcggc attcccgatt  1500
ctgatggcgc gtaatgataa aaactactgg ctggcgtttg gcgaaaaacg cgcctgggat  1560
aaaaatgagc tggcgtacat tacggaagcg ccttccattg tgcagccaga gaacgttacg  1620
cgcgatactg cgactttcaa cctgccgttt atttcgctgg ggcaagtcgg tgaaggcaaa  1680
ctgatggtta tcggtaaccc gcactacaac agcatcctgc gttgcccgaa cggttacagt  1740
tggggcggtg gtgttaatag taaaggtgag tgtacgctca gcggtgattc tgatgacatg  1800
aagcacttta tgcagaacgt actgcgctac ttgtcaaatg acatctggca gccaaatacc  1860
aagagcatca tgactgtcgg caccaacctg gagaacgttt atttcaaaaa agcgggccag  1920
gtattgggaa atagtgcacc atttgctttc catgaggatt tcactggtat cacggttaaa  1980
cagttgacca gctatggcga tctgaatccg gaagagattc cgttgctgat cctcaacggc  2040
tttgaatatg tgactcagtg gtctggcgat ccctatgctg tgcctctgcg tgcagatacc  2100
agcaaaccga agctgactca gcaggatgtg accgatctga tcgcttatct gaacaaaggt  2160
ggctcggtgc tgatcatgga aaacgtgatg agcaatctta aggaagagag cgcgtccagt  2220
tttgtgcgtc tgctggatgc cgcgggtctg tcaatggctc tgaacaaatc ggtggtgaac  2280
aacgatccgc aagggtatcc ggatcgcgtt cgtcagcgtc gcgcgactgg catttgggtt  2340
tatgaacgtt atcctgctgc agacggcgcg caaccgccgt acaccatcga cccaaataca  2400
ggggaagtga cctggaaata ccagcaagac aacaagcctg atgacaagcc gaaactggaa  2460
gttgcgagct ggcaggagga agttgagggc aaacaggtaa cgcgttatgc ctttattgat  2520
gaagcggaat acacaacaga agaatctctg gaagcggcaa aggcaaaaat ctttgagaag  2580
tttcctgggt tacaggagtg taaggactcg acttaccatt acgagattaa ctgtttggag  2640
cgccgcccag gcacggatgt tccggtaaca ggtggcatgt atgttccgcg ctatacgcaa  2700
ctgaatcttg acgccgacac cgcgaaagcg atggtgcagg cggcggattt aggcaccaac  2760
attcagcgcc tgtatcagca tgagctttat ttccgtacca aaggcagtaa aggtgagcgt  2820
ctgaacagtg ttgatctgga acgtctgtac cagaacatgt cggtctggct gtggaacgat  2880
acgaaatatc gttacgaaga gggcaaggaa gatgagctgg gctttaaaac gttcaccgag  2940
ttcctgaact gctacgccaa tgatgcctat gcaggcggca ccaagtgctc cgcagatctg  3000
aaaaaatcgc tggtcgataa caacatgatc tacggtgacg gtagcagcaa agcgggcatg  3060
atgaacccaa gctatccgct caactatatg gaaaaaccgc tgacgcgtct gatgctgggc  3120
cgttcctggt gggatctgaa cattaaggtt gatgtggaga agtacccagg atccgtatcg  3180
gcaaagggtg agagcgttac ggaaaacatc agcctgtact cgaatccgac caaatggttt  3240
gcgggtaaca tgcagtcaac cggcctgtgg gcaccggccc agcaggacgt caccattaag  3300
tcttcggcgt cagtcccagt gactgttacc gtggcgctgg ctgacgacct gactggacgt  3360
gagaagcatg aagttgcgct gaaccgtccg ccaagagtga ctaaaacgta tactctggag  3420
gctaacggtg aagtgacctt caaggtgcct tatggtggtc tgatttatat caagggcgac  3480
agtaaggatg atgtttctgc taacttcacc tttaccggtg tagtaaaagc gccgttctat  3540
aaagacggcg aatggaaaaa cgatctggac tcaccggcgc cgctgggcga gctggagtct  3600
gcgtcgttcg tctataccac gccgaagaag aaccttgagg ccagcaattt cactggtggt  3660
gtagcagaat tcgctaaaga tctggatacc tttgccagct cgatgaatga cttctacggt  3720
cgtaatgatg aagacggtaa gcaccggatg tttacctata aaaacttgac ggggcacaag  3780
catcgtttca ccaacgatgt gcagatctcc atcggtgatg cgcactcggg ttatccggta  3840
atgaacagca gcttctcgac gaacagcacc acgctgccga cgacgccgct gaacgactgg  3900
ctgatttggc acgaagtcgg tcataacgct gcagaaacac cgctgaacgt accgggtgca  3960
actgaagtgg cgaacaacgt gctggcgctg tacatgcagg atcgctatct cggtaagatg  4020
aaccgtgtcg ctgacgacat taccgtcgcg ccggaatatc tggacgagag caacggtcag  4080
gcctgggcgc gcggcggtgc gggtgaccgt ctgctgatgt acgcacagtt gaaggagtgg  4140
gcagaggaaa actttgatat caaacagtgg tatccagatg gtgagctgcc taagttctac  4200
agcgatcgta aagggatgaa gggctggaac ctgttccagt tgatgcaccg taaagcgcgc  4260
ggcgatgatg ttggtaacag cacctttggt ggcaagaatt actgtgctga atccaatggt  4320
aacgctgccg acacgctgat gctgtgtgca tcctgggtcg ctcaggcgga tctttcggaa  4380
ttctttaaga aatggaatcc gggtgcaagt gcttaccagt tgccgggagc aacggagatg  4440
agtttccagg gcggtgtgag ctcttcggct tacagcacgc tggcgtcact caagctgccg  4500
aaaccggaaa aagggccgga aaccattaac aaggttaccg agcataagat gtctgccgag  4560

<210>   8
<211>   1520
<212>   PRT
<213>   Escherichia coli

<400>   8
Met Asn Lys Lys Phe Lys Tyr Lys Lys Ser Leu Leu Ala Ala Ile Leu 
1               5                   10                  15      

Ser Ala Thr Leu Leu Ala Gly Cys Asp Gly Gly Gly Ser Gly Ser Ser 
            20                  25                  30          

Ser Asp Thr Pro Ser Val Asp Ser Gly Ser Gly Thr Leu Pro Glu Val 
        35                  40                  45              

Lys Pro Asp Pro Thr Pro Thr Pro Glu Pro Thr Pro Glu Pro Thr Pro 
    50                  55                  60                  

Asp Pro Glu Pro Thr Pro Asp Pro Thr Pro Asp Pro Glu Pro Thr Pro 
65                  70                  75                  80  

Glu Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu 
                85                  90                  95      

Gly Gly Ser Gln Arg Val Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser 
            100                 105                 110         

Asp Gly Phe Thr Phe Thr Pro Gly Asn Thr Val Ser Cys Val Val Gly 
        115                 120                 125             

Ser Thr Thr Ile Ala Thr Phe Asn Thr Gln Ser Glu Ala Ala Arg Ser 
    130                 135                 140                 

Leu Arg Ala Val Asp Lys Val Ser Phe Ser Leu Glu Asp Ala Gln Glu 
145                 150                 155                 160 

Leu Ala Asn Ser Glu Asn Lys Lys Thr Asn Ala Ile Ser Leu Val Thr 
                165                 170                 175     

Ser Ser Asp Ser Cys Pro Ala Asp Ala Glu Gln Leu Cys Leu Thr Phe 
            180                 185                 190         

Ser Ser Val Val Asp Arg Ala Arg Phe Glu Lys Leu Tyr Lys Gln Ile 
        195                 200                 205             

Asp Leu Ala Thr Asp Asn Phe Ser Lys Leu Val Asn Glu Glu Val Glu 
    210                 215                 220                 

Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Thr Val 
225                 230                 235                 240 

Val Pro Val Thr Thr Glu Gly Thr Lys Pro Asp Leu Asn Ala Ser Phe 
                245                 250                 255     

Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu Ile 
            260                 265                 270         

Ile Leu Ser Glu Gly Gln Leu Val Asp Ser Leu Gly Asn Gly Val Ala 
        275                 280                 285             

Gly Val Asp Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Asp Glu Asn 
    290                 295                 300                 

Gly Lys Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile Asp 
305                 310                 315                 320 

Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala Leu 
                325                 330                 335     

Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu Ile 
            340                 345                 350         

His Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val Pro Asp 
        355                 360                 365             

Asp Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu Ile 
    370                 375                 380                 

Ile Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Asp Glu Gly Asp Gln 
385                 390                 395                 400 

Asn Val Val Leu Pro Asn Glu Phe Ile Glu Gln Phe Lys Thr Gly Gln 
                405                 410                 415     

Ala Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly Cys Asn 
            420                 425                 430         

Glu Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly Gln 
        435                 440                 445             

Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn Tyr Gln 
    450                 455                 460                 

Ser Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr Gly 
465                 470                 475                 480 

Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn Ser 
                485                 490                 495     

Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu Ala 
            500                 505                 510         

Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile Thr 
        515                 520                 525             

Glu Ala Pro Ser Ile Val Gln Pro Glu Asn Val Thr Arg Asp Thr Ala 
    530                 535                 540                 

Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Glu Gly Lys 
545                 550                 555                 560 

Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys Pro 
                565                 570                 575     

Asn Gly Tyr Ser Trp Gly Gly Gly Val Asn Ser Lys Gly Glu Cys Thr 
            580                 585                 590         

Leu Ser Gly Asp Ser Asp Asp Met Lys His Phe Met Gln Asn Val Leu 
        595                 600                 605             

Arg Tyr Leu Ser Asn Asp Ile Trp Gln Pro Asn Thr Lys Ser Ile Met 
    610                 615                 620                 

Thr Val Gly Thr Asn Leu Glu Asn Val Tyr Phe Lys Lys Ala Gly Gln 
625                 630                 635                 640 

Val Leu Gly Asn Ser Ala Pro Phe Ala Phe His Glu Asp Phe Thr Gly 
                645                 650                 655     

Ile Thr Val Lys Gln Leu Thr Ser Tyr Gly Asp Leu Asn Pro Glu Glu 
            660                 665                 670         

Ile Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Trp Ser 
        675                 680                 685             

Gly Asp Pro Tyr Ala Val Pro Leu Arg Ala Asp Thr Ser Lys Pro Lys 
    690                 695                 700                 

Leu Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn Lys Gly 
705                 710                 715                 720 

Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu Glu 
                725                 730                 735     

Ser Ala Ser Ser Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser Met 
            740                 745                 750         

Ala Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro Asp 
        755                 760                 765             

Arg Val Arg Gln Arg Arg Ala Thr Gly Ile Trp Val Tyr Glu Arg Tyr 
    770                 775                 780                 

Pro Ala Ala Asp Gly Ala Gln Pro Pro Tyr Thr Ile Asp Pro Asn Thr 
785                 790                 795                 800 

Gly Glu Val Thr Trp Lys Tyr Gln Gln Asp Asn Lys Pro Asp Asp Lys 
                805                 810                 815     

Pro Lys Leu Glu Val Ala Ser Trp Gln Glu Glu Val Glu Gly Lys Gln 
            820                 825                 830         

Val Thr Arg Tyr Ala Phe Ile Asp Glu Ala Glu Tyr Thr Thr Glu Glu 
        835                 840                 845             

Ser Leu Glu Ala Ala Lys Ala Lys Ile Phe Glu Lys Phe Pro Gly Leu 
    850                 855                 860                 

Gln Glu Cys Lys Asp Ser Thr Tyr His Tyr Glu Ile Asn Cys Leu Glu 
865                 870                 875                 880 

Arg Arg Pro Gly Thr Asp Val Pro Val Thr Gly Gly Met Tyr Val Pro 
                885                 890                 895     

Arg Tyr Thr Gln Leu Asn Leu Asp Ala Asp Thr Ala Lys Ala Met Val 
            900                 905                 910         

Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu 
        915                 920                 925             

Leu Tyr Phe Arg Thr Lys Gly Ser Lys Gly Glu Arg Leu Asn Ser Val 
    930                 935                 940                 

Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Asp 
945                 950                 955                 960 

Thr Lys Tyr Arg Tyr Glu Glu Gly Lys Glu Asp Glu Leu Gly Phe Lys 
                965                 970                 975     

Thr Phe Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asp Ala Tyr Ala Gly 
            980                 985                 990         

Gly Thr Lys Cys Ser Ala Asp Leu Lys Lys Ser Leu Val Asp Asn Asn 
        995                 1000                1005            

Met Ile Tyr Gly Asp Gly Ser Ser Lys Ala Gly Met Met Asn Pro Ser 
    1010                1015                1020                

Tyr Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly 
1025                1030                1035                1040

Arg Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro 
                1045                1050                1055    

Gly Ser Val Ser Ala Lys Gly Glu Ser Val Thr Glu Asn Ile Ser Leu 
            1060                1065                1070        

Tyr Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly 
        1075                1080                1085            

Leu Trp Ala Pro Ala Gln Gln Asp Val Thr Ile Lys Ser Ser Ala Ser 
    1090                1095                1100                

Val Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg 
1105                1110                1115                1120

Glu Lys His Glu Val Ala Leu Asn Arg Pro Pro Arg Val Thr Lys Thr 
                1125                1130                1135    

Tyr Thr Leu Glu Ala Asn Gly Glu Val Thr Phe Lys Val Pro Tyr Gly 
            1140                1145                1150        

Gly Leu Ile Tyr Ile Lys Gly Asp Ser Lys Asp Asp Val Ser Ala Asn 
        1155                1160                1165            

Phe Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Glu 
    1170                1175                1180                

Trp Lys Asn Asp Leu Asp Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser 
1185                1190                1195                1200

Ala Ser Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Glu Ala Ser Asn 
                1205                1210                1215    

Phe Thr Gly Gly Val Ala Glu Phe Ala Lys Asp Leu Asp Thr Phe Ala 
            1220                1225                1230        

Ser Ser Met Asn Asp Phe Tyr Gly Arg Asn Asp Glu Asp Gly Lys His 
        1235                1240                1245            

Arg Met Phe Thr Tyr Lys Asn Leu Thr Gly His Lys His Arg Phe Thr 
    1250                1255                1260                

Asn Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val 
1265                1270                1275                1280

Met Asn Ser Ser Phe Ser Thr Asn Ser Thr Thr Leu Pro Thr Thr Pro 
                1285                1290                1295    

Leu Asn Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala Glu 
            1300                1305                1310        

Thr Pro Leu Asn Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu 
        1315                1320                1325            

Ala Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala 
    1330                1335                1340                

Asp Asp Ile Thr Val Ala Pro Glu Tyr Leu Asp Glu Ser Asn Gly Gln 
1345                1350                1355                1360

Ala Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln 
                1365                1370                1375    

Leu Lys Glu Trp Ala Glu Glu Asn Phe Asp Ile Lys Gln Trp Tyr Pro 
            1380                1385                1390        

Asp Gly Glu Leu Pro Lys Phe Tyr Ser Asp Arg Lys Gly Met Lys Gly 
        1395                1400                1405            

Trp Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Asp Val 
    1410                1415                1420                

Gly Asn Ser Thr Phe Gly Gly Lys Asn Tyr Cys Ala Glu Ser Asn Gly 
1425                1430                1435                1440

Asn Ala Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln Ala 
                1445                1450                1455    

Asp Leu Ser Glu Phe Phe Lys Lys Trp Asn Pro Gly Ala Ser Ala Tyr 
            1460                1465                1470        

Gln Leu Pro Gly Ala Thr Glu Met Ser Phe Gln Gly Gly Val Ser Ser 
        1475                1480                1485            

Ser Ala Tyr Ser Thr Leu Ala Ser Leu Lys Leu Pro Lys Pro Glu Lys 
    1490                1495                1500                

Gly Pro Glu Thr Ile Asn Lys Val Thr Glu His Lys Met Ser Ala Glu 
1505                1510                1515                1520

<210>   9
<211>   2214
<212>   DNA
<213>   Escherichia coli

<400>   9
tgtgatggtg gtggttcagg atcgtcctcc gatacgccgt ctgtagattc tggatcaggg  60
actttgccgg aagtgaaacc cgatccaaca ccaaccccgg agccgacacc tgagccgacg  120
ccggacccag aacctacgcc ggatccaaca cctgatcctg agccgacacc agaaccggag  180
ccagaacctg ttcctacgaa aacgggttat ctgaccctgg gcggaagcca gcgggtaact  240
ggtgctacct gtaatggtga atccagcgat ggctttacct ttacgccagg caataccgtg  300
agttgtgtgg tgggcagtac gaccattgca acattcaaca cccagtcaga agctgcgcgt  360
agcctgcgtg cggttgacaa agtgtcgttt agcctggagg acgcgcagga gctggcgaat  420
tctgaaaata agaaaaccaa cgccatctct ctggtgacgt ccagcgacag ttgccccgca  480
gatgcagaac agctttgtct tactttctcg tcagtggttg atcgcgcgcg atttgaaaaa  540
ctgtataagc aaattgatct ggcaacagac aatttcagca agctggtcaa tgaagaggtg  600
gaaaacaatg ctgcgactga taaagcgccg tccacccata cctcaacggt agtgccagtc  660
acgacagagg gaacaaaacc ggatctgaac gcgtccttcg tgtcggctaa cgcggaacag  720
ttttatcagt atcaacccac tgaaatcatt ctttccgaag gccaactggt ggatagcctg  780
gggaacggtg ttgctggcgt tgactactac accaattcag gccgtggcgt aactgacgaa  840
aacggtaaat tttcctttag ctggggcgaa accatctcct ttggtatcga tacctttgaa  900
ctgggctcag tacgtggcaa taagtcgacc attgcgctga ctgaattggg tgatgaagtt  960
cgcggggcaa atatcgatca gctcattcat cgttattcga cgactggtca aaataatact  1020
cgtgttgttc cggacgatgt acgcaaggtc tttgccgaat atcccaacgt gatcaacgag  1080
ataatcaatc tttcgttatc caacggtgcg acgctggatg aaggcgatca aaacgttgtg  1140
ctgcctaacg aatttatcga gcagtttaag acgggtcagg ccaaagagat cgataccgcg  1200
atttgtgcga aaaccgacgg ttgtaacgag gctcgctggt tctcgctgac aacgcgcaat  1260
gttaatgacg gccagattca gggcgttatt aacaagctgt ggggcgtgga tacgaactat  1320
cagtctgtca gcaagttcca cgtcttccat gactctacca acttctatgg cagcaccggt  1380
aacgcgcgcg gtcaggcggt ggtaaatatc tccaactcgg cattcccgat tctgatggcg  1440
cgtaatgata aaaactactg gctggcgttt ggcgaaaaac gcgcctggga taaaaatgag  1500
ctggcgtaca ttacggaagc gccttccatt gtgcagccag agaacgttac gcgcgatact  1560
gcgactttca acctgccgtt tatttcgctg gggcaagtcg gtgaaggcaa actgatggtt  1620
atcggtaacc cgcactacaa cagcatcctg cgttgcccga acggttacag ttggggcggt  1680
ggtgttaata gtaaaggtga gtgtacgctc agcggtgatt ctgatgacat gaagcacttt  1740
atgcagaacg tactgcgcta cttgtcaaat gacatctggc agccaaatac caagagcatc  1800
atgactgtcg gcaccaacct ggagaacgtt tatttcaaaa aagcgggcca ggtattggga  1860
aatagtgcac catttgcttt ccatgaggat ttcactggta tcacggttaa acagttgacc  1920
agctatggcg atctgaatcc ggaagagatt ccgttgctga tcctcaacgg ctttgaatat  1980
gtgactcagt ggtctggcga tccctatgct gtgcctctgc gtgcagatac cagcaaaccg  2040
aagctgactc agcaggatgt gaccgatctg atcgcttatc tgaacaaagg tggctcggtg  2100
ctgatcatgg aaaacgtgat gagcaatctt aaggaagaga gcgcgtccag ttttgtgcgt  2160
ctgctggatg ccgcgggtct gtcaatggct ctgaacaaat cggtggtgaa caac        2214

<210>   10
<211>   738
<212>   PRT
<213>   Escherichia coli

<400>   10
Cys Asp Gly Gly Gly Ser Gly Ser Ser Ser Asp Thr Pro Ser Val Asp 
1               5                   10                  15      

Ser Gly Ser Gly Thr Leu Pro Glu Val Lys Pro Asp Pro Thr Pro Thr 
            20                  25                  30          

Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp Pro Glu Pro Thr Pro Asp 
        35                  40                  45              

Pro Thr Pro Asp Pro Glu Pro Thr Pro Glu Pro Glu Pro Glu Pro Val 
    50                  55                  60                  

Pro Thr Lys Thr Gly Tyr Leu Thr Leu Gly Gly Ser Gln Arg Val Thr 
65                  70                  75                  80  

Gly Ala Thr Cys Asn Gly Glu Ser Ser Asp Gly Phe Thr Phe Thr Pro 
                85                  90                  95      

Gly Asn Thr Val Ser Cys Val Val Gly Ser Thr Thr Ile Ala Thr Phe 
            100                 105                 110         

Asn Thr Gln Ser Glu Ala Ala Arg Ser Leu Arg Ala Val Asp Lys Val 
        115                 120                 125             

Ser Phe Ser Leu Glu Asp Ala Gln Glu Leu Ala Asn Ser Glu Asn Lys 
    130                 135                 140                 

Lys Thr Asn Ala Ile Ser Leu Val Thr Ser Ser Asp Ser Cys Pro Ala 
145                 150                 155                 160 

Asp Ala Glu Gln Leu Cys Leu Thr Phe Ser Ser Val Val Asp Arg Ala 
                165                 170                 175     

Arg Phe Glu Lys Leu Tyr Lys Gln Ile Asp Leu Ala Thr Asp Asn Phe 
            180                 185                 190         

Ser Lys Leu Val Asn Glu Glu Val Glu Asn Asn Ala Ala Thr Asp Lys 
        195                 200                 205             

Ala Pro Ser Thr His Thr Ser Thr Val Val Pro Val Thr Thr Glu Gly 
    210                 215                 220                 

Thr Lys Pro Asp Leu Asn Ala Ser Phe Val Ser Ala Asn Ala Glu Gln 
225                 230                 235                 240 

Phe Tyr Gln Tyr Gln Pro Thr Glu Ile Ile Leu Ser Glu Gly Gln Leu 
                245                 250                 255     

Val Asp Ser Leu Gly Asn Gly Val Ala Gly Val Asp Tyr Tyr Thr Asn 
            260                 265                 270         

Ser Gly Arg Gly Val Thr Asp Glu Asn Gly Lys Phe Ser Phe Ser Trp 
        275                 280                 285             

Gly Glu Thr Ile Ser Phe Gly Ile Asp Thr Phe Glu Leu Gly Ser Val 
    290                 295                 300                 

Arg Gly Asn Lys Ser Thr Ile Ala Leu Thr Glu Leu Gly Asp Glu Val 
305                 310                 315                 320 

Arg Gly Ala Asn Ile Asp Gln Leu Ile His Arg Tyr Ser Thr Thr Gly 
                325                 330                 335     

Gln Asn Asn Thr Arg Val Val Pro Asp Asp Val Arg Lys Val Phe Ala 
            340                 345                 350         

Glu Tyr Pro Asn Val Ile Asn Glu Ile Ile Asn Leu Ser Leu Ser Asn 
        355                 360                 365             

Gly Ala Thr Leu Asp Glu Gly Asp Gln Asn Val Val Leu Pro Asn Glu 
    370                 375                 380                 

Phe Ile Glu Gln Phe Lys Thr Gly Gln Ala Lys Glu Ile Asp Thr Ala 
385                 390                 395                 400 

Ile Cys Ala Lys Thr Asp Gly Cys Asn Glu Ala Arg Trp Phe Ser Leu 
                405                 410                 415     

Thr Thr Arg Asn Val Asn Asp Gly Gln Ile Gln Gly Val Ile Asn Lys 
            420                 425                 430         

Leu Trp Gly Val Asp Thr Asn Tyr Gln Ser Val Ser Lys Phe His Val 
        435                 440                 445             

Phe His Asp Ser Thr Asn Phe Tyr Gly Ser Thr Gly Asn Ala Arg Gly 
    450                 455                 460                 

Gln Ala Val Val Asn Ile Ser Asn Ser Ala Phe Pro Ile Leu Met Ala 
465                 470                 475                 480 

Arg Asn Asp Lys Asn Tyr Trp Leu Ala Phe Gly Glu Lys Arg Ala Trp 
                485                 490                 495     

Asp Lys Asn Glu Leu Ala Tyr Ile Thr Glu Ala Pro Ser Ile Val Gln 
            500                 505                 510         

Pro Glu Asn Val Thr Arg Asp Thr Ala Thr Phe Asn Leu Pro Phe Ile 
        515                 520                 525             

Ser Leu Gly Gln Val Gly Glu Gly Lys Leu Met Val Ile Gly Asn Pro 
    530                 535                 540                 

His Tyr Asn Ser Ile Leu Arg Cys Pro Asn Gly Tyr Ser Trp Gly Gly 
545                 550                 555                 560 

Gly Val Asn Ser Lys Gly Glu Cys Thr Leu Ser Gly Asp Ser Asp Asp 
                565                 570                 575     

Met Lys His Phe Met Gln Asn Val Leu Arg Tyr Leu Ser Asn Asp Ile 
            580                 585                 590         

Trp Gln Pro Asn Thr Lys Ser Ile Met Thr Val Gly Thr Asn Leu Glu 
        595                 600                 605             

Asn Val Tyr Phe Lys Lys Ala Gly Gln Val Leu Gly Asn Ser Ala Pro 
    610                 615                 620                 

Phe Ala Phe His Glu Asp Phe Thr Gly Ile Thr Val Lys Gln Leu Thr 
625                 630                 635                 640 

Ser Tyr Gly Asp Leu Asn Pro Glu Glu Ile Pro Leu Leu Ile Leu Asn 
                645                 650                 655     

Gly Phe Glu Tyr Val Thr Gln Trp Ser Gly Asp Pro Tyr Ala Val Pro 
            660                 665                 670         

Leu Arg Ala Asp Thr Ser Lys Pro Lys Leu Thr Gln Gln Asp Val Thr 
        675                 680                 685             

Asp Leu Ile Ala Tyr Leu Asn Lys Gly Gly Ser Val Leu Ile Met Glu 
    690                 695                 700                 

Asn Val Met Ser Asn Leu Lys Glu Glu Ser Ala Ser Ser Phe Val Arg 
705                 710                 715                 720 

Leu Leu Asp Ala Ala Gly Leu Ser Met Ala Leu Asn Lys Ser Val Val 
                725                 730                 735     

Asn Asn 
        

<210>   11
<211>   2277
<212>   DNA
<213>   Escherichia coli

<400>   11
gatccgcaag ggtatccgga tcgcgttcgt cagcgtcgcg cgactggcat ttgggtttat  60
gaacgttatc ctgctgcaga cggcgcgcaa ccgccgtaca ccatcgaccc aaatacaggg  120
gaagtgacct ggaaatacca gcaagacaac aagcctgatg acaagccgaa actggaagtt  180
gcgagctggc aggaggaagt tgagggcaaa caggtaacgc gttatgcctt tattgatgaa  240
gcggaataca caacagaaga atctctggaa gcggcaaagg caaaaatctt tgagaagttt  300
cctgggttac aggagtgtaa ggactcgact taccattacg agattaactg tttggagcgc  360
cgcccaggca cggatgttcc ggtaacaggt ggcatgtatg ttccgcgcta tacgcaactg  420
aatcttgacg ccgacaccgc gaaagcgatg gtgcaggcgg cggatttagg caccaacatt  480
cagcgcctgt atcagcatga gctttatttc cgtaccaaag gcagtaaagg tgagcgtctg  540
aacagtgttg atctggaacg tctgtaccag aacatgtcgg tctggctgtg gaacgatacg  600
aaatatcgtt acgaagaggg caaggaagat gagctgggct ttaaaacgtt caccgagttc  660
ctgaactgct acgccaatga tgcctatgca ggcggcacca agtgctccgc agatctgaaa  720
aaatcgctgg tcgataacaa catgatctac ggtgacggta gcagcaaagc gggcatgatg  780
aacccaagct atccgctcaa ctatatggaa aaaccgctga cgcgtctgat gctgggccgt  840
tcctggtggg atctgaacat taaggttgat gtggagaagt acccaggatc cgtatcggca  900
aagggtgaga gcgttacgga aaacatcagc ctgtactcga atccgaccaa atggtttgcg  960
ggtaacatgc agtcaaccgg cctgtgggca ccggcccagc aggacgtcac cattaagtct  1020
tcggcgtcag tcccagtgac tgttaccgtg gcgctggctg acgacctgac tggacgtgag  1080
aagcatgaag ttgcgctgaa ccgtccgcca agagtgacta aaacgtatac tctggaggct  1140
aacggtgaag tgaccttcaa ggtgccttat ggtggtctga tttatatcaa gggcgacagt  1200
aaggatgatg tttctgctaa cttcaccttt accggtgtag taaaagcgcc gttctataaa  1260
gacggcgaat ggaaaaacga tctggactca ccggcgccgc tgggcgagct ggagtctgcg  1320
tcgttcgtct ataccacgcc gaagaagaac cttgaggcca gcaatttcac tggtggtgta  1380
gcagaattcg ctaaagatct ggataccttt gccagctcga tgaatgactt ctacggtcgt  1440
aatgatgaag acggtaagca ccggatgttt acctataaaa acttgacggg gcacaagcat  1500
cgtttcacca acgatgtgca gatctccatc ggtgatgcgc actcgggtta tccggtaatg  1560
aacagcagct tctcgacgaa cagcaccacg ctgccgacga cgccgctgaa cgactggctg  1620
atttggcacg aagtcggtca taacgctgca gaaacaccgc tgaacgtacc gggtgcaact  1680
gaagtggcga acaacgtgct ggcgctgtac atgcaggatc gctatctcgg taagatgaac  1740
cgtgtcgctg acgacattac cgtcgcgccg gaatatctgg acgagagcaa cggtcaggcc  1800
tgggcgcgcg gcggtgcggg tgaccgtctg ctgatgtacg cacagttgaa ggagtgggca  1860
gaggaaaact ttgatatcaa acagtggtat ccagatggtg agctgcctaa gttctacagc  1920
gatcgtaaag ggatgaaggg ctggaacctg ttccagttga tgcaccgtaa agcgcgcggc  1980
gatgatgttg gtaacagcac ctttggtggc aagaattact gtgctgaatc caatggtaac  2040
gctgccgaca cgctgatgct gtgtgcatcc tgggtcgctc aggcggatct ttcggaattc  2100
tttaagaaat ggaatccggg tgcaagtgct taccagttgc cgggagcaac ggagatgagt  2160
ttccagggcg gtgtgagctc ttcggcttac agcacgctgg cgtcactcaa gctgccgaaa  2220
ccggaaaaag ggccggaaac cattaacaag gttaccgagc ataagatgtc tgccgag     2277

<210>   12
<211>   759
<212>   PRT
<213>   Escherichia coli

<400>   12
Asp Pro Gln Gly Tyr Pro Asp Arg Val Arg Gln Arg Arg Ala Thr Gly 
1               5                   10                  15      

Ile Trp Val Tyr Glu Arg Tyr Pro Ala Ala Asp Gly Ala Gln Pro Pro 
            20                  25                  30          

Tyr Thr Ile Asp Pro Asn Thr Gly Glu Val Thr Trp Lys Tyr Gln Gln 
        35                  40                  45              

Asp Asn Lys Pro Asp Asp Lys Pro Lys Leu Glu Val Ala Ser Trp Gln 
    50                  55                  60                  

Glu Glu Val Glu Gly Lys Gln Val Thr Arg Tyr Ala Phe Ile Asp Glu 
65                  70                  75                  80  

Ala Glu Tyr Thr Thr Glu Glu Ser Leu Glu Ala Ala Lys Ala Lys Ile 
                85                  90                  95      

Phe Glu Lys Phe Pro Gly Leu Gln Glu Cys Lys Asp Ser Thr Tyr His 
            100                 105                 110         

Tyr Glu Ile Asn Cys Leu Glu Arg Arg Pro Gly Thr Asp Val Pro Val 
        115                 120                 125             

Thr Gly Gly Met Tyr Val Pro Arg Tyr Thr Gln Leu Asn Leu Asp Ala 
    130                 135                 140                 

Asp Thr Ala Lys Ala Met Val Gln Ala Ala Asp Leu Gly Thr Asn Ile 
145                 150                 155                 160 

Gln Arg Leu Tyr Gln His Glu Leu Tyr Phe Arg Thr Lys Gly Ser Lys 
                165                 170                 175     

Gly Glu Arg Leu Asn Ser Val Asp Leu Glu Arg Leu Tyr Gln Asn Met 
            180                 185                 190         

Ser Val Trp Leu Trp Asn Asp Thr Lys Tyr Arg Tyr Glu Glu Gly Lys 
        195                 200                 205             

Glu Asp Glu Leu Gly Phe Lys Thr Phe Thr Glu Phe Leu Asn Cys Tyr 
    210                 215                 220                 

Ala Asn Asp Ala Tyr Ala Gly Gly Thr Lys Cys Ser Ala Asp Leu Lys 
225                 230                 235                 240 

Lys Ser Leu Val Asp Asn Asn Met Ile Tyr Gly Asp Gly Ser Ser Lys 
                245                 250                 255     

Ala Gly Met Met Asn Pro Ser Tyr Pro Leu Asn Tyr Met Glu Lys Pro 
            260                 265                 270         

Leu Thr Arg Leu Met Leu Gly Arg Ser Trp Trp Asp Leu Asn Ile Lys 
        275                 280                 285             

Val Asp Val Glu Lys Tyr Pro Gly Ser Val Ser Ala Lys Gly Glu Ser 
    290                 295                 300                 

Val Thr Glu Asn Ile Ser Leu Tyr Ser Asn Pro Thr Lys Trp Phe Ala 
305                 310                 315                 320 

Gly Asn Met Gln Ser Thr Gly Leu Trp Ala Pro Ala Gln Gln Asp Val 
                325                 330                 335     

Thr Ile Lys Ser Ser Ala Ser Val Pro Val Thr Val Thr Val Ala Leu 
            340                 345                 350         

Ala Asp Asp Leu Thr Gly Arg Glu Lys His Glu Val Ala Leu Asn Arg 
        355                 360                 365             

Pro Pro Arg Val Thr Lys Thr Tyr Thr Leu Glu Ala Asn Gly Glu Val 
    370                 375                 380                 

Thr Phe Lys Val Pro Tyr Gly Gly Leu Ile Tyr Ile Lys Gly Asp Ser 
385                 390                 395                 400 

Lys Asp Asp Val Ser Ala Asn Phe Thr Phe Thr Gly Val Val Lys Ala 
                405                 410                 415     

Pro Phe Tyr Lys Asp Gly Glu Trp Lys Asn Asp Leu Asp Ser Pro Ala 
            420                 425                 430         

Pro Leu Gly Glu Leu Glu Ser Ala Ser Phe Val Tyr Thr Thr Pro Lys 
        435                 440                 445             

Lys Asn Leu Glu Ala Ser Asn Phe Thr Gly Gly Val Ala Glu Phe Ala 
    450                 455                 460                 

Lys Asp Leu Asp Thr Phe Ala Ser Ser Met Asn Asp Phe Tyr Gly Arg 
465                 470                 475                 480 

Asn Asp Glu Asp Gly Lys His Arg Met Phe Thr Tyr Lys Asn Leu Thr 
                485                 490                 495     

Gly His Lys His Arg Phe Thr Asn Asp Val Gln Ile Ser Ile Gly Asp 
            500                 505                 510         

Ala His Ser Gly Tyr Pro Val Met Asn Ser Ser Phe Ser Thr Asn Ser 
        515                 520                 525             

Thr Thr Leu Pro Thr Thr Pro Leu Asn Asp Trp Leu Ile Trp His Glu 
    530                 535                 540                 

Val Gly His Asn Ala Ala Glu Thr Pro Leu Asn Val Pro Gly Ala Thr 
545                 550                 555                 560 

Glu Val Ala Asn Asn Val Leu Ala Leu Tyr Met Gln Asp Arg Tyr Leu 
                565                 570                 575     

Gly Lys Met Asn Arg Val Ala Asp Asp Ile Thr Val Ala Pro Glu Tyr 
            580                 585                 590         

Leu Asp Glu Ser Asn Gly Gln Ala Trp Ala Arg Gly Gly Ala Gly Asp 
        595                 600                 605             

Arg Leu Leu Met Tyr Ala Gln Leu Lys Glu Trp Ala Glu Glu Asn Phe 
    610                 615                 620                 

Asp Ile Lys Gln Trp Tyr Pro Asp Gly Glu Leu Pro Lys Phe Tyr Ser 
625                 630                 635                 640 

Asp Arg Lys Gly Met Lys Gly Trp Asn Leu Phe Gln Leu Met His Arg 
                645                 650                 655     

Lys Ala Arg Gly Asp Asp Val Gly Asn Ser Thr Phe Gly Gly Lys Asn 
            660                 665                 670         

Tyr Cys Ala Glu Ser Asn Gly Asn Ala Ala Asp Thr Leu Met Leu Cys 
        675                 680                 685             

Ala Ser Trp Val Ala Gln Ala Asp Leu Ser Glu Phe Phe Lys Lys Trp 
    690                 695                 700                 

Asn Pro Gly Ala Ser Ala Tyr Gln Leu Pro Gly Ala Thr Glu Met Ser 
705                 710                 715                 720 

Phe Gln Gly Gly Val Ser Ser Ser Ala Tyr Ser Thr Leu Ala Ser Leu 
                725                 730                 735     

Lys Leu Pro Lys Pro Glu Lys Gly Pro Glu Thr Ile Asn Lys Val Thr 
            740                 745                 750         

Glu His Lys Met Ser Ala Glu 
        755                 

<210>   13
<211>   4461
<212>   DNA
<213>   Escherichia coli

<400>   13
gatacgccgt ctgtagattc tggatcaggg actttgccgg aagtgaaacc cgatccaaca  60
ccaaccccgg agccgacacc tgagccgacg ccggacccag aacctacgcc ggatccaaca  120
cctgatcctg agccgacacc agaaccggag ccagaacctg ttcctacgaa aacgggttat  180
ctgaccctgg gcggaagcca gcgggtaact ggtgctacct gtaatggtga atccagcgat  240
ggctttacct ttacgccagg caataccgtg agttgtgtgg tgggcagtac gaccattgca  300
acattcaaca cccagtcaga agctgcgcgt agcctgcgtg cggttgacaa agtgtcgttt  360
agcctggagg acgcgcagga gctggcgaat tctgaaaata agaaaaccaa cgccatctct  420
ctggtgacgt ccagcgacag ttgccccgca gatgcagaac agctttgtct tactttctcg  480
tcagtggttg atcgcgcgcg atttgaaaaa ctgtataagc aaattgatct ggcaacagac  540
aatttcagca agctggtcaa tgaagaggtg gaaaacaatg ctgcgactga taaagcgccg  600
tccacccata cctcaacggt agtgccagtc acgacagagg gaacaaaacc ggatctgaac  660
gcgtccttcg tgtcggctaa cgcggaacag ttttatcagt atcaacccac tgaaatcatt  720
ctttccgaag gccaactggt ggatagcctg gggaacggtg ttgctggcgt tgactactac  780
accaattcag gccgtggcgt aactgacgaa aacggtaaat tttcctttag ctggggcgaa  840
accatctcct ttggtatcga tacctttgaa ctgggctcag tacgtggcaa taagtcgacc  900
attgcgctga ctgaattggg tgatgaagtt cgcggggcaa atatcgatca gctcattcat  960
cgttattcga cgactggtca aaataatact cgtgttgttc cggacgatgt acgcaaggtc  1020
tttgccgaat atcccaacgt gatcaacgag ataatcaatc tttcgttatc caacggtgcg  1080
acgctggatg aaggcgatca aaacgttgtg ctgcctaacg aatttatcga gcagtttaag  1140
acgggtcagg ccaaagagat cgataccgcg atttgtgcga aaaccgacgg ttgtaacgag  1200
gctcgctggt tctcgctgac aacgcgcaat gttaatgacg gccagattca gggcgttatt  1260
aacaagctgt ggggcgtgga tacgaactat cagtctgtca gcaagttcca cgtcttccat  1320
gactctacca acttctatgg cagcaccggt aacgcgcgcg gtcaggcggt ggtaaatatc  1380
tccaactcgg cattcccgat tctgatggcg cgtaatgata aaaactactg gctggcgttt  1440
ggcgaaaaac gcgcctggga taaaaatgag ctggcgtaca ttacggaagc gccttccatt  1500
gtgcagccag agaacgttac gcgcgatact gcgactttca acctgccgtt tatttcgctg  1560
gggcaagtcg gtgaaggcaa actgatggtt atcggtaacc cgcactacaa cagcatcctg  1620
cgttgcccga acggttacag ttggggcggt ggtgttaata gtaaaggtga gtgtacgctc  1680
agcggtgatt ctgatgacat gaagcacttt atgcagaacg tactgcgcta cttgtcaaat  1740
gacatctggc agccaaatac caagagcatc atgactgtcg gcaccaacct ggagaacgtt  1800
tatttcaaaa aagcgggcca ggtattggga aatagtgcac catttgcttt ccatgaggat  1860
ttcactggta tcacggttaa acagttgacc agctatggcg atctgaatcc ggaagagatt  1920
ccgttgctga tcctcaacgg ctttgaatat gtgactcagt ggtctggcga tccctatgct  1980
gtgcctctgc gtgcagatac cagcaaaccg aagctgactc agcaggatgt gaccgatctg  2040
atcgcttatc tgaacaaagg tggctcggtg ctgatcatgg aaaacgtgat gagcaatctt  2100
aaggaagaga gcgcgtccag ttttgtgcgt ctgctggatg ccgcgggtct gtcaatggct  2160
ctgaacaaat cggtggtgaa caacgatccg caagggtatc cggatcgcgt tcgtcagcgt  2220
cgcgcgactg gcatttgggt ttatgaacgt tatcctgctg cagacggcgc gcaaccgccg  2280
tacaccatcg acccaaatac aggggaagtg acctggaaat accagcaaga caacaagcct  2340
gatgacaagc cgaaactgga agttgcgagc tggcaggagg aagttgaggg caaacaggta  2400
acgcgttatg cctttattga tgaagcggaa tacacaacag aagaatctct ggaagcggca  2460
aaggcaaaaa tctttgagaa gtttcctggg ttacaggagt gtaaggactc gacttaccat  2520
tacgagatta actgtttgga gcgccgccca ggcacggatg ttccggtaac aggtggcatg  2580
tatgttccgc gctatacgca actgaatctt gacgccgaca ccgcgaaagc gatggtgcag  2640
gcggcggatt taggcaccaa cattcagcgc ctgtatcagc atgagcttta tttccgtacc  2700
aaaggcagta aaggtgagcg tctgaacagt gttgatctgg aacgtctgta ccagaacatg  2760
tcggtctggc tgtggaacga tacgaaatat cgttacgaag agggcaagga agatgagctg  2820
ggctttaaaa cgttcaccga gttcctgaac tgctacgcca atgatgccta tgcaggcggc  2880
accaagtgct ccgcagatct gaaaaaatcg ctggtcgata acaacatgat ctacggtgac  2940
ggtagcagca aagcgggcat gatgaaccca agctatccgc tcaactatat ggaaaaaccg  3000
ctgacgcgtc tgatgctggg ccgttcctgg tgggatctga acattaaggt tgatgtggag  3060
aagtacccag gatccgtatc ggcaaagggt gagagcgtta cggaaaacat cagcctgtac  3120
tcgaatccga ccaaatggtt tgcgggtaac atgcagtcaa ccggcctgtg ggcaccggcc  3180
cagcaggacg tcaccattaa gtcttcggcg tcagtcccag tgactgttac cgtggcgctg  3240
gctgacgacc tgactggacg tgagaagcat gaagttgcgc tgaaccgtcc gccaagagtg  3300
actaaaacgt atactctgga ggctaacggt gaagtgacct tcaaggtgcc ttatggtggt  3360
ctgatttata tcaagggcga cagtaaggat gatgtttctg ctaacttcac ctttaccggt  3420
gtagtaaaag cgccgttcta taaagacggc gaatggaaaa acgatctgga ctcaccggcg  3480
ccgctgggcg agctggagtc tgcgtcgttc gtctatacca cgccgaagaa gaaccttgag  3540
gccagcaatt tcactggtgg tgtagcagaa ttcgctaaag atctggatac ctttgccagc  3600
tcgatgaatg acttctacgg tcgtaatgat gaagacggta agcaccggat gtttacctat  3660
aaaaacttga cggggcacaa gcatcgtttc accaacgatg tgcagatctc catcggtgat  3720
gcgcactcgg gttatccggt aatgaacagc agcttctcga cgaacagcac cacgctgccg  3780
acgacgccgc tgaacgactg gctgatttgg cacgaagtcg gtcataacgc tgcagaaaca  3840
ccgctgaacg taccgggtgc aactgaagtg gcgaacaacg tgctggcgct gtacatgcag  3900
gatcgctatc tcggtaagat gaaccgtgtc gctgacgaca ttaccgtcgc gccggaatat  3960
ctggacgaga gcaacggtca ggcctgggcg cgcggcggtg cgggtgaccg tctgctgatg  4020
tacgcacagt tgaaggagtg ggcagaggaa aactttgata tcaaacagtg gtatccagat  4080
ggtgagctgc ctaagttcta cagcgatcgt aaagggatga agggctggaa cctgttccag  4140
ttgatgcacc gtaaagcgcg cggcgatgat gttggtaaca gcacctttgg tggcaagaat  4200
tactgtgctg aatccaatgg taacgctgcc gacacgctga tgctgtgtgc atcctgggtc  4260
gctcaggcgg atctttcgga attctttaag aaatggaatc cgggtgcaag tgcttaccag  4320
ttgccgggag caacggagat gagtttccag ggcggtgtga gctcttcggc ttacagcacg  4380
ctggcgtcac tcaagctgcc gaaaccggaa aaagggccgg aaaccattaa caaggttacc  4440
gagcataaga tgtctgccga g                                            4461

<210>   14
<211>   1487
<212>   PRT
<213>   Escherichia coli

<400>   14
Asp Thr Pro Ser Val Asp Ser Gly Ser Gly Thr Leu Pro Glu Val Lys 
1               5                   10                  15      

Pro Asp Pro Thr Pro Thr Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp 
            20                  25                  30          

Pro Glu Pro Thr Pro Asp Pro Thr Pro Asp Pro Glu Pro Thr Pro Glu 
        35                  40                  45              

Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu Gly 
    50                  55                  60                  

Gly Ser Gln Arg Val Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser Asp 
65                  70                  75                  80  

Gly Phe Thr Phe Thr Pro Gly Asn Thr Val Ser Cys Val Val Gly Ser 
                85                  90                  95      

Thr Thr Ile Ala Thr Phe Asn Thr Gln Ser Glu Ala Ala Arg Ser Leu 
            100                 105                 110         

Arg Ala Val Asp Lys Val Ser Phe Ser Leu Glu Asp Ala Gln Glu Leu 
        115                 120                 125             

Ala Asn Ser Glu Asn Lys Lys Thr Asn Ala Ile Ser Leu Val Thr Ser 
    130                 135                 140                 

Ser Asp Ser Cys Pro Ala Asp Ala Glu Gln Leu Cys Leu Thr Phe Ser 
145                 150                 155                 160 

Ser Val Val Asp Arg Ala Arg Phe Glu Lys Leu Tyr Lys Gln Ile Asp 
                165                 170                 175     

Leu Ala Thr Asp Asn Phe Ser Lys Leu Val Asn Glu Glu Val Glu Asn 
            180                 185                 190         

Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Thr Val Val 
        195                 200                 205             

Pro Val Thr Thr Glu Gly Thr Lys Pro Asp Leu Asn Ala Ser Phe Val 
    210                 215                 220                 

Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu Ile Ile 
225                 230                 235                 240 

Leu Ser Glu Gly Gln Leu Val Asp Ser Leu Gly Asn Gly Val Ala Gly 
                245                 250                 255     

Val Asp Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Asp Glu Asn Gly 
            260                 265                 270         

Lys Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile Asp Thr 
        275                 280                 285             

Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala Leu Thr 
    290                 295                 300                 

Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu Ile His 
305                 310                 315                 320 

Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val Pro Asp Asp 
                325                 330                 335     

Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu Ile Ile 
            340                 345                 350         

Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Asp Glu Gly Asp Gln Asn 
        355                 360                 365             

Val Val Leu Pro Asn Glu Phe Ile Glu Gln Phe Lys Thr Gly Gln Ala 
    370                 375                 380                 

Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly Cys Asn Glu 
385                 390                 395                 400 

Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly Gln Ile 
                405                 410                 415     

Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn Tyr Gln Ser 
            420                 425                 430         

Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr Gly Ser 
        435                 440                 445             

Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn Ser Ala 
    450                 455                 460                 

Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu Ala Phe 
465                 470                 475                 480 

Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile Thr Glu 
                485                 490                 495     

Ala Pro Ser Ile Val Gln Pro Glu Asn Val Thr Arg Asp Thr Ala Thr 
            500                 505                 510         

Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Glu Gly Lys Leu 
        515                 520                 525             

Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys Pro Asn 
    530                 535                 540                 

Gly Tyr Ser Trp Gly Gly Gly Val Asn Ser Lys Gly Glu Cys Thr Leu 
545                 550                 555                 560 

Ser Gly Asp Ser Asp Asp Met Lys His Phe Met Gln Asn Val Leu Arg 
                565                 570                 575     

Tyr Leu Ser Asn Asp Ile Trp Gln Pro Asn Thr Lys Ser Ile Met Thr 
            580                 585                 590         

Val Gly Thr Asn Leu Glu Asn Val Tyr Phe Lys Lys Ala Gly Gln Val 
        595                 600                 605             

Leu Gly Asn Ser Ala Pro Phe Ala Phe His Glu Asp Phe Thr Gly Ile 
    610                 615                 620                 

Thr Val Lys Gln Leu Thr Ser Tyr Gly Asp Leu Asn Pro Glu Glu Ile 
625                 630                 635                 640 

Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Trp Ser Gly 
                645                 650                 655     

Asp Pro Tyr Ala Val Pro Leu Arg Ala Asp Thr Ser Lys Pro Lys Leu 
            660                 665                 670         

Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn Lys Gly Gly 
        675                 680                 685             

Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu Glu Ser 
    690                 695                 700                 

Ala Ser Ser Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser Met Ala 
705                 710                 715                 720 

Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro Asp Arg 
                725                 730                 735     

Val Arg Gln Arg Arg Ala Thr Gly Ile Trp Val Tyr Glu Arg Tyr Pro 
            740                 745                 750         

Ala Ala Asp Gly Ala Gln Pro Pro Tyr Thr Ile Asp Pro Asn Thr Gly 
        755                 760                 765             

Glu Val Thr Trp Lys Tyr Gln Gln Asp Asn Lys Pro Asp Asp Lys Pro 
    770                 775                 780                 

Lys Leu Glu Val Ala Ser Trp Gln Glu Glu Val Glu Gly Lys Gln Val 
785                 790                 795                 800 

Thr Arg Tyr Ala Phe Ile Asp Glu Ala Glu Tyr Thr Thr Glu Glu Ser 
                805                 810                 815     

Leu Glu Ala Ala Lys Ala Lys Ile Phe Glu Lys Phe Pro Gly Leu Gln 
            820                 825                 830         

Glu Cys Lys Asp Ser Thr Tyr His Tyr Glu Ile Asn Cys Leu Glu Arg 
        835                 840                 845             

Arg Pro Gly Thr Asp Val Pro Val Thr Gly Gly Met Tyr Val Pro Arg 
    850                 855                 860                 

Tyr Thr Gln Leu Asn Leu Asp Ala Asp Thr Ala Lys Ala Met Val Gln 
865                 870                 875                 880 

Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu Leu 
                885                 890                 895     

Tyr Phe Arg Thr Lys Gly Ser Lys Gly Glu Arg Leu Asn Ser Val Asp 
            900                 905                 910         

Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Asp Thr 
        915                 920                 925             

Lys Tyr Arg Tyr Glu Glu Gly Lys Glu Asp Glu Leu Gly Phe Lys Thr 
    930                 935                 940                 

Phe Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asp Ala Tyr Ala Gly Gly 
945                 950                 955                 960 

Thr Lys Cys Ser Ala Asp Leu Lys Lys Ser Leu Val Asp Asn Asn Met 
                965                 970                 975     

Ile Tyr Gly Asp Gly Ser Ser Lys Ala Gly Met Met Asn Pro Ser Tyr 
            980                 985                 990         

Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly Arg 
        995                 1000                1005            

Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro Gly 
    1010                1015                1020                

Ser Val Ser Ala Lys Gly Glu Ser Val Thr Glu Asn Ile Ser Leu Tyr 
1025                1030                1035                1040

Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly Leu 
                1045                1050                1055    

Trp Ala Pro Ala Gln Gln Asp Val Thr Ile Lys Ser Ser Ala Ser Val 
            1060                1065                1070        

Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg Glu 
        1075                1080                1085            

Lys His Glu Val Ala Leu Asn Arg Pro Pro Arg Val Thr Lys Thr Tyr 
    1090                1095                1100                

Thr Leu Glu Ala Asn Gly Glu Val Thr Phe Lys Val Pro Tyr Gly Gly 
1105                1110                1115                1120

Leu Ile Tyr Ile Lys Gly Asp Ser Lys Asp Asp Val Ser Ala Asn Phe 
                1125                1130                1135    

Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Glu Trp 
            1140                1145                1150        

Lys Asn Asp Leu Asp Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser Ala 
        1155                1160                1165            

Ser Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Glu Ala Ser Asn Phe 
    1170                1175                1180                

Thr Gly Gly Val Ala Glu Phe Ala Lys Asp Leu Asp Thr Phe Ala Ser 
1185                1190                1195                1200

Ser Met Asn Asp Phe Tyr Gly Arg Asn Asp Glu Asp Gly Lys His Arg 
                1205                1210                1215    

Met Phe Thr Tyr Lys Asn Leu Thr Gly His Lys His Arg Phe Thr Asn 
            1220                1225                1230        

Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val Met 
        1235                1240                1245            

Asn Ser Ser Phe Ser Thr Asn Ser Thr Thr Leu Pro Thr Thr Pro Leu 
    1250                1255                1260                

Asn Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala Glu Thr 
1265                1270                1275                1280

Pro Leu Asn Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu Ala 
                1285                1290                1295    

Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala Asp 
            1300                1305                1310        

Asp Ile Thr Val Ala Pro Glu Tyr Leu Asp Glu Ser Asn Gly Gln Ala 
        1315                1320                1325            

Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln Leu 
    1330                1335                1340                

Lys Glu Trp Ala Glu Glu Asn Phe Asp Ile Lys Gln Trp Tyr Pro Asp 
1345                1350                1355                1360

Gly Glu Leu Pro Lys Phe Tyr Ser Asp Arg Lys Gly Met Lys Gly Trp 
                1365                1370                1375    

Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Asp Val Gly 
            1380                1385                1390        

Asn Ser Thr Phe Gly Gly Lys Asn Tyr Cys Ala Glu Ser Asn Gly Asn 
        1395                1400                1405            

Ala Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln Ala Asp 
    1410                1415                1420                

Leu Ser Glu Phe Phe Lys Lys Trp Asn Pro Gly Ala Ser Ala Tyr Gln 
1425                1430                1435                1440

Leu Pro Gly Ala Thr Glu Met Ser Phe Gln Gly Gly Val Ser Ser Ser 
                1445                1450                1455    

Ala Tyr Ser Thr Leu Ala Ser Leu Lys Leu Pro Lys Pro Glu Lys Gly 
            1460                1465                1470        

Pro Glu Thr Ile Asn Lys Val Thr Glu His Lys Met Ser Ala Glu 
        1475                1480                1485        

<210>   15
<211>   4293
<212>   DNA
<213>   Escherichia coli

<400>   15
aaaacgggtt atctgaccct gggcggaagc cagcgggtaa ctggtgctac ctgtaatggt  60
gaatccagcg atggctttac ctttacgcca ggcaataccg tgagttgtgt ggtgggcagt  120
acgaccattg caacattcaa cacccagtca gaagctgcgc gtagcctgcg tgcggttgac  180
aaagtgtcgt ttagcctgga ggacgcgcag gagctggcga attctgaaaa taagaaaacc  240
aacgccatct ctctggtgac gtccagcgac agttgccccg cagatgcaga acagctttgt  300
cttactttct cgtcagtggt tgatcgcgcg cgatttgaaa aactgtataa gcaaattgat  360
ctggcaacag acaatttcag caagctggtc aatgaagagg tggaaaacaa tgctgcgact  420
gataaagcgc cgtccaccca tacctcaacg gtagtgccag tcacgacaga gggaacaaaa  480
ccggatctga acgcgtcctt cgtgtcggct aacgcggaac agttttatca gtatcaaccc  540
actgaaatca ttctttccga aggccaactg gtggatagcc tggggaacgg tgttgctggc  600
gttgactact acaccaattc aggccgtggc gtaactgacg aaaacggtaa attttccttt  660
agctggggcg aaaccatctc ctttggtatc gatacctttg aactgggctc agtacgtggc  720
aataagtcga ccattgcgct gactgaattg ggtgatgaag ttcgcggggc aaatatcgat  780
cagctcattc atcgttattc gacgactggt caaaataata ctcgtgttgt tccggacgat  840
gtacgcaagg tctttgccga atatcccaac gtgatcaacg agataatcaa tctttcgtta  900
tccaacggtg cgacgctgga tgaaggcgat caaaacgttg tgctgcctaa cgaatttatc  960
gagcagttta agacgggtca ggccaaagag atcgataccg cgatttgtgc gaaaaccgac  1020
ggttgtaacg aggctcgctg gttctcgctg acaacgcgca atgttaatga cggccagatt  1080
cagggcgtta ttaacaagct gtggggcgtg gatacgaact atcagtctgt cagcaagttc  1140
cacgtcttcc atgactctac caacttctat ggcagcaccg gtaacgcgcg cggtcaggcg  1200
gtggtaaata tctccaactc ggcattcccg attctgatgg cgcgtaatga taaaaactac  1260
tggctggcgt ttggcgaaaa acgcgcctgg gataaaaatg agctggcgta cattacggaa  1320
gcgccttcca ttgtgcagcc agagaacgtt acgcgcgata ctgcgacttt caacctgccg  1380
tttatttcgc tggggcaagt cggtgaaggc aaactgatgg ttatcggtaa cccgcactac  1440
aacagcatcc tgcgttgccc gaacggttac agttggggcg gtggtgttaa tagtaaaggt  1500
gagtgtacgc tcagcggtga ttctgatgac atgaagcact ttatgcagaa cgtactgcgc  1560
tacttgtcaa atgacatctg gcagccaaat accaagagca tcatgactgt cggcaccaac  1620
ctggagaacg tttatttcaa aaaagcgggc caggtattgg gaaatagtgc accatttgct  1680
ttccatgagg atttcactgg tatcacggtt aaacagttga ccagctatgg cgatctgaat  1740
ccggaagaga ttccgttgct gatcctcaac ggctttgaat atgtgactca gtggtctggc  1800
gatccctatg ctgtgcctct gcgtgcagat accagcaaac cgaagctgac tcagcaggat  1860
gtgaccgatc tgatcgctta tctgaacaaa ggtggctcgg tgctgatcat ggaaaacgtg  1920
atgagcaatc ttaaggaaga gagcgcgtcc agttttgtgc gtctgctgga tgccgcgggt  1980
ctgtcaatgg ctctgaacaa atcggtggtg aacaacgatc cgcaagggta tccggatcgc  2040
gttcgtcagc gtcgcgcgac tggcatttgg gtttatgaac gttatcctgc tgcagacggc  2100
gcgcaaccgc cgtacaccat cgacccaaat acaggggaag tgacctggaa ataccagcaa  2160
gacaacaagc ctgatgacaa gccgaaactg gaagttgcga gctggcagga ggaagttgag  2220
ggcaaacagg taacgcgtta tgcctttatt gatgaagcgg aatacacaac agaagaatct  2280
ctggaagcgg caaaggcaaa aatctttgag aagtttcctg ggttacagga gtgtaaggac  2340
tcgacttacc attacgagat taactgtttg gagcgccgcc caggcacgga tgttccggta  2400
acaggtggca tgtatgttcc gcgctatacg caactgaatc ttgacgccga caccgcgaaa  2460
gcgatggtgc aggcggcgga tttaggcacc aacattcagc gcctgtatca gcatgagctt  2520
tatttccgta ccaaaggcag taaaggtgag cgtctgaaca gtgttgatct ggaacgtctg  2580
taccagaaca tgtcggtctg gctgtggaac gatacgaaat atcgttacga agagggcaag  2640
gaagatgagc tgggctttaa aacgttcacc gagttcctga actgctacgc caatgatgcc  2700
tatgcaggcg gcaccaagtg ctccgcagat ctgaaaaaat cgctggtcga taacaacatg  2760
atctacggtg acggtagcag caaagcgggc atgatgaacc caagctatcc gctcaactat  2820
atggaaaaac cgctgacgcg tctgatgctg ggccgttcct ggtgggatct gaacattaag  2880
gttgatgtgg agaagtaccc aggatccgta tcggcaaagg gtgagagcgt tacggaaaac  2940
atcagcctgt actcgaatcc gaccaaatgg tttgcgggta acatgcagtc aaccggcctg  3000
tgggcaccgg cccagcagga cgtcaccatt aagtcttcgg cgtcagtccc agtgactgtt  3060
accgtggcgc tggctgacga cctgactgga cgtgagaagc atgaagttgc gctgaaccgt  3120
ccgccaagag tgactaaaac gtatactctg gaggctaacg gtgaagtgac cttcaaggtg  3180
ccttatggtg gtctgattta tatcaagggc gacagtaagg atgatgtttc tgctaacttc  3240
acctttaccg gtgtagtaaa agcgccgttc tataaagacg gcgaatggaa aaacgatctg  3300
gactcaccgg cgccgctggg cgagctggag tctgcgtcgt tcgtctatac cacgccgaag  3360
aagaaccttg aggccagcaa tttcactggt ggtgtagcag aattcgctaa agatctggat  3420
acctttgcca gctcgatgaa tgacttctac ggtcgtaatg atgaagacgg taagcaccgg  3480
atgtttacct ataaaaactt gacggggcac aagcatcgtt tcaccaacga tgtgcagatc  3540
tccatcggtg atgcgcactc gggttatccg gtaatgaaca gcagcttctc gacgaacagc  3600
accacgctgc cgacgacgcc gctgaacgac tggctgattt ggcacgaagt cggtcataac  3660
gctgcagaaa caccgctgaa cgtaccgggt gcaactgaag tggcgaacaa cgtgctggcg  3720
ctgtacatgc aggatcgcta tctcggtaag atgaaccgtg tcgctgacga cattaccgtc  3780
gcgccggaat atctggacga gagcaacggt caggcctggg cgcgcggcgg tgcgggtgac  3840
cgtctgctga tgtacgcaca gttgaaggag tgggcagagg aaaactttga tatcaaacag  3900
tggtatccag atggtgagct gcctaagttc tacagcgatc gtaaagggat gaagggctgg  3960
aacctgttcc agttgatgca ccgtaaagcg cgcggcgatg atgttggtaa cagcaccttt  4020
ggtggcaaga attactgtgc tgaatccaat ggtaacgctg ccgacacgct gatgctgtgt  4080
gcatcctggg tcgctcaggc ggatctttcg gaattcttta agaaatggaa tccgggtgca  4140
agtgcttacc agttgccggg agcaacggag atgagtttcc agggcggtgt gagctcttcg  4200
gcttacagca cgctggcgtc actcaagctg ccgaaaccgg aaaaagggcc ggaaaccatt  4260
aacaaggtta ccgagcataa gatgtctgcc gag                               4293

<210>   16
<211>   1431
<212>   PRT
<213>   Escherichia coli

<400>   16
Lys Thr Gly Tyr Leu Thr Leu Gly Gly Ser Gln Arg Val Thr Gly Ala 
1               5                   10                  15      

Thr Cys Asn Gly Glu Ser Ser Asp Gly Phe Thr Phe Thr Pro Gly Asn 
            20                  25                  30          

Thr Val Ser Cys Val Val Gly Ser Thr Thr Ile Ala Thr Phe Asn Thr 
        35                  40                  45              

Gln Ser Glu Ala Ala Arg Ser Leu Arg Ala Val Asp Lys Val Ser Phe 
    50                  55                  60                  

Ser Leu Glu Asp Ala Gln Glu Leu Ala Asn Ser Glu Asn Lys Lys Thr 
65                  70                  75                  80  

Asn Ala Ile Ser Leu Val Thr Ser Ser Asp Ser Cys Pro Ala Asp Ala 
                85                  90                  95      

Glu Gln Leu Cys Leu Thr Phe Ser Ser Val Val Asp Arg Ala Arg Phe 
            100                 105                 110         

Glu Lys Leu Tyr Lys Gln Ile Asp Leu Ala Thr Asp Asn Phe Ser Lys 
        115                 120                 125             

Leu Val Asn Glu Glu Val Glu Asn Asn Ala Ala Thr Asp Lys Ala Pro 
    130                 135                 140                 

Ser Thr His Thr Ser Thr Val Val Pro Val Thr Thr Glu Gly Thr Lys 
145                 150                 155                 160 

Pro Asp Leu Asn Ala Ser Phe Val Ser Ala Asn Ala Glu Gln Phe Tyr 
                165                 170                 175     

Gln Tyr Gln Pro Thr Glu Ile Ile Leu Ser Glu Gly Gln Leu Val Asp 
            180                 185                 190         

Ser Leu Gly Asn Gly Val Ala Gly Val Asp Tyr Tyr Thr Asn Ser Gly 
        195                 200                 205             

Arg Gly Val Thr Asp Glu Asn Gly Lys Phe Ser Phe Ser Trp Gly Glu 
    210                 215                 220                 

Thr Ile Ser Phe Gly Ile Asp Thr Phe Glu Leu Gly Ser Val Arg Gly 
225                 230                 235                 240 

Asn Lys Ser Thr Ile Ala Leu Thr Glu Leu Gly Asp Glu Val Arg Gly 
                245                 250                 255     

Ala Asn Ile Asp Gln Leu Ile His Arg Tyr Ser Thr Thr Gly Gln Asn 
            260                 265                 270         

Asn Thr Arg Val Val Pro Asp Asp Val Arg Lys Val Phe Ala Glu Tyr 
        275                 280                 285             

Pro Asn Val Ile Asn Glu Ile Ile Asn Leu Ser Leu Ser Asn Gly Ala 
    290                 295                 300                 

Thr Leu Asp Glu Gly Asp Gln Asn Val Val Leu Pro Asn Glu Phe Ile 
305                 310                 315                 320 

Glu Gln Phe Lys Thr Gly Gln Ala Lys Glu Ile Asp Thr Ala Ile Cys 
                325                 330                 335     

Ala Lys Thr Asp Gly Cys Asn Glu Ala Arg Trp Phe Ser Leu Thr Thr 
            340                 345                 350         

Arg Asn Val Asn Asp Gly Gln Ile Gln Gly Val Ile Asn Lys Leu Trp 
        355                 360                 365             

Gly Val Asp Thr Asn Tyr Gln Ser Val Ser Lys Phe His Val Phe His 
    370                 375                 380                 

Asp Ser Thr Asn Phe Tyr Gly Ser Thr Gly Asn Ala Arg Gly Gln Ala 
385                 390                 395                 400 

Val Val Asn Ile Ser Asn Ser Ala Phe Pro Ile Leu Met Ala Arg Asn 
                405                 410                 415     

Asp Lys Asn Tyr Trp Leu Ala Phe Gly Glu Lys Arg Ala Trp Asp Lys 
            420                 425                 430         

Asn Glu Leu Ala Tyr Ile Thr Glu Ala Pro Ser Ile Val Gln Pro Glu 
        435                 440                 445             

Asn Val Thr Arg Asp Thr Ala Thr Phe Asn Leu Pro Phe Ile Ser Leu 
    450                 455                 460                 

Gly Gln Val Gly Glu Gly Lys Leu Met Val Ile Gly Asn Pro His Tyr 
465                 470                 475                 480 

Asn Ser Ile Leu Arg Cys Pro Asn Gly Tyr Ser Trp Gly Gly Gly Val 
                485                 490                 495     

Asn Ser Lys Gly Glu Cys Thr Leu Ser Gly Asp Ser Asp Asp Met Lys 
            500                 505                 510         

His Phe Met Gln Asn Val Leu Arg Tyr Leu Ser Asn Asp Ile Trp Gln 
        515                 520                 525             

Pro Asn Thr Lys Ser Ile Met Thr Val Gly Thr Asn Leu Glu Asn Val 
    530                 535                 540                 

Tyr Phe Lys Lys Ala Gly Gln Val Leu Gly Asn Ser Ala Pro Phe Ala 
545                 550                 555                 560 

Phe His Glu Asp Phe Thr Gly Ile Thr Val Lys Gln Leu Thr Ser Tyr 
                565                 570                 575     

Gly Asp Leu Asn Pro Glu Glu Ile Pro Leu Leu Ile Leu Asn Gly Phe 
            580                 585                 590         

Glu Tyr Val Thr Gln Trp Ser Gly Asp Pro Tyr Ala Val Pro Leu Arg 
        595                 600                 605             

Ala Asp Thr Ser Lys Pro Lys Leu Thr Gln Gln Asp Val Thr Asp Leu 
    610                 615                 620                 

Ile Ala Tyr Leu Asn Lys Gly Gly Ser Val Leu Ile Met Glu Asn Val 
625                 630                 635                 640 

Met Ser Asn Leu Lys Glu Glu Ser Ala Ser Ser Phe Val Arg Leu Leu 
                645                 650                 655     

Asp Ala Ala Gly Leu Ser Met Ala Leu Asn Lys Ser Val Val Asn Asn 
            660                 665                 670         

Asp Pro Gln Gly Tyr Pro Asp Arg Val Arg Gln Arg Arg Ala Thr Gly 
        675                 680                 685             

Ile Trp Val Tyr Glu Arg Tyr Pro Ala Ala Asp Gly Ala Gln Pro Pro 
    690                 695                 700                 

Tyr Thr Ile Asp Pro Asn Thr Gly Glu Val Thr Trp Lys Tyr Gln Gln 
705                 710                 715                 720 

Asp Asn Lys Pro Asp Asp Lys Pro Lys Leu Glu Val Ala Ser Trp Gln 
                725                 730                 735     

Glu Glu Val Glu Gly Lys Gln Val Thr Arg Tyr Ala Phe Ile Asp Glu 
            740                 745                 750         

Ala Glu Tyr Thr Thr Glu Glu Ser Leu Glu Ala Ala Lys Ala Lys Ile 
        755                 760                 765             

Phe Glu Lys Phe Pro Gly Leu Gln Glu Cys Lys Asp Ser Thr Tyr His 
    770                 775                 780                 

Tyr Glu Ile Asn Cys Leu Glu Arg Arg Pro Gly Thr Asp Val Pro Val 
785                 790                 795                 800 

Thr Gly Gly Met Tyr Val Pro Arg Tyr Thr Gln Leu Asn Leu Asp Ala 
                805                 810                 815     

Asp Thr Ala Lys Ala Met Val Gln Ala Ala Asp Leu Gly Thr Asn Ile 
            820                 825                 830         

Gln Arg Leu Tyr Gln His Glu Leu Tyr Phe Arg Thr Lys Gly Ser Lys 
        835                 840                 845             

Gly Glu Arg Leu Asn Ser Val Asp Leu Glu Arg Leu Tyr Gln Asn Met 
    850                 855                 860                 

Ser Val Trp Leu Trp Asn Asp Thr Lys Tyr Arg Tyr Glu Glu Gly Lys 
865                 870                 875                 880 

Glu Asp Glu Leu Gly Phe Lys Thr Phe Thr Glu Phe Leu Asn Cys Tyr 
                885                 890                 895     

Ala Asn Asp Ala Tyr Ala Gly Gly Thr Lys Cys Ser Ala Asp Leu Lys 
            900                 905                 910         

Lys Ser Leu Val Asp Asn Asn Met Ile Tyr Gly Asp Gly Ser Ser Lys 
        915                 920                 925             

Ala Gly Met Met Asn Pro Ser Tyr Pro Leu Asn Tyr Met Glu Lys Pro 
    930                 935                 940                 

Leu Thr Arg Leu Met Leu Gly Arg Ser Trp Trp Asp Leu Asn Ile Lys 
945                 950                 955                 960 

Val Asp Val Glu Lys Tyr Pro Gly Ser Val Ser Ala Lys Gly Glu Ser 
                965                 970                 975     

Val Thr Glu Asn Ile Ser Leu Tyr Ser Asn Pro Thr Lys Trp Phe Ala 
            980                 985                 990         

Gly Asn Met Gln Ser Thr Gly Leu Trp Ala Pro Ala Gln Gln Asp Val 
        995                 1000                1005            

Thr Ile Lys Ser Ser Ala Ser Val Pro Val Thr Val Thr Val Ala Leu 
    1010                1015                1020                

Ala Asp Asp Leu Thr Gly Arg Glu Lys His Glu Val Ala Leu Asn Arg 
1025                1030                1035                1040

Pro Pro Arg Val Thr Lys Thr Tyr Thr Leu Glu Ala Asn Gly Glu Val 
                1045                1050                1055    

Thr Phe Lys Val Pro Tyr Gly Gly Leu Ile Tyr Ile Lys Gly Asp Ser 
            1060                1065                1070        

Lys Asp Asp Val Ser Ala Asn Phe Thr Phe Thr Gly Val Val Lys Ala 
        1075                1080                1085            

Pro Phe Tyr Lys Asp Gly Glu Trp Lys Asn Asp Leu Asp Ser Pro Ala 
    1090                1095                1100                

Pro Leu Gly Glu Leu Glu Ser Ala Ser Phe Val Tyr Thr Thr Pro Lys 
1105                1110                1115                1120

Lys Asn Leu Glu Ala Ser Asn Phe Thr Gly Gly Val Ala Glu Phe Ala 
                1125                1130                1135    

Lys Asp Leu Asp Thr Phe Ala Ser Ser Met Asn Asp Phe Tyr Gly Arg 
            1140                1145                1150        

Asn Asp Glu Asp Gly Lys His Arg Met Phe Thr Tyr Lys Asn Leu Thr 
        1155                1160                1165            

Gly His Lys His Arg Phe Thr Asn Asp Val Gln Ile Ser Ile Gly Asp 
    1170                1175                1180                

Ala His Ser Gly Tyr Pro Val Met Asn Ser Ser Phe Ser Thr Asn Ser 
1185                1190                1195                1200

Thr Thr Leu Pro Thr Thr Pro Leu Asn Asp Trp Leu Ile Trp His Glu 
                1205                1210                1215    

Val Gly His Asn Ala Ala Glu Thr Pro Leu Asn Val Pro Gly Ala Thr 
            1220                1225                1230        

Glu Val Ala Asn Asn Val Leu Ala Leu Tyr Met Gln Asp Arg Tyr Leu 
        1235                1240                1245            

Gly Lys Met Asn Arg Val Ala Asp Asp Ile Thr Val Ala Pro Glu Tyr 
    1250                1255                1260                

Leu Asp Glu Ser Asn Gly Gln Ala Trp Ala Arg Gly Gly Ala Gly Asp 
1265                1270                1275                1280

Arg Leu Leu Met Tyr Ala Gln Leu Lys Glu Trp Ala Glu Glu Asn Phe 
                1285                1290                1295    

Asp Ile Lys Gln Trp Tyr Pro Asp Gly Glu Leu Pro Lys Phe Tyr Ser 
            1300                1305                1310        

Asp Arg Lys Gly Met Lys Gly Trp Asn Leu Phe Gln Leu Met His Arg 
        1315                1320                1325            

Lys Ala Arg Gly Asp Asp Val Gly Asn Ser Thr Phe Gly Gly Lys Asn 
    1330                1335                1340                

Tyr Cys Ala Glu Ser Asn Gly Asn Ala Ala Asp Thr Leu Met Leu Cys 
1345                1350                1355                1360

Ala Ser Trp Val Ala Gln Ala Asp Leu Ser Glu Phe Phe Lys Lys Trp 
                1365                1370                1375    

Asn Pro Gly Ala Ser Ala Tyr Gln Leu Pro Gly Ala Thr Glu Met Ser 
            1380                1385                1390        

Phe Gln Gly Gly Val Ser Ser Ser Ala Tyr Ser Thr Leu Ala Ser Leu 
        1395                1400                1405            

Lys Leu Pro Lys Pro Glu Lys Gly Pro Glu Thr Ile Asn Lys Val Thr 
    1410                1415                1420                

Glu His Lys Met Ser Ala Glu 
1425                1430    

<210>   17
<211>   4491
<212>   DNA
<213>   Escherichia coli

<400>   17
tgtgatggtg gtggttcagg atcgtcctcc gatacgccgt ctgtagattc tggatcaggg  60
actttgccgg aagtgaaacc cgatccaaca ccaaccccgg agccgacacc tgagccgacg  120
ccggacccag aacctacgcc ggatccaaca cctgatcctg agccgacacc agaaccggag  180
ccagaacctg ttcctacgaa aacgggttat ctgaccctgg gcggaagcca gcgggtaact  240
ggtgctacct gtaatggtga atccagcgat ggctttacct ttacgccagg caataccgtg  300
agttgtgtgg tgggcagtac gaccattgca acattcaaca cccagtcaga agctgcgcgt  360
agcctgcgtg cggttgacaa agtgtcgttt agcctggagg acgcgcagga gctggcgaat  420
tctgaaaata agaaaaccaa cgccatctct ctggtgacgt ccagcgacag ttgccccgca  480
gatgcagaac agctttgtct tactttctcg tcagtggttg atcgcgcgcg atttgaaaaa  540
ctgtataagc aaattgatct ggcaacagac aatttcagca agctggtcaa tgaagaggtg  600
gaaaacaatg ctgcgactga taaagcgccg tccacccata cctcaacggt agtgccagtc  660
acgacagagg gaacaaaacc ggatctgaac gcgtccttcg tgtcggctaa cgcggaacag  720
ttttatcagt atcaacccac tgaaatcatt ctttccgaag gccaactggt ggatagcctg  780
gggaacggtg ttgctggcgt tgactactac accaattcag gccgtggcgt aactgacgaa  840
aacggtaaat tttcctttag ctggggcgaa accatctcct ttggtatcga tacctttgaa  900
ctgggctcag tacgtggcaa taagtcgacc attgcgctga ctgaattggg tgatgaagtt  960
cgcggggcaa atatcgatca gctcattcat cgttattcga cgactggtca aaataatact  1020
cgtgttgttc cggacgatgt acgcaaggtc tttgccgaat atcccaacgt gatcaacgag  1080
ataatcaatc tttcgttatc caacggtgcg acgctggatg aaggcgatca aaacgttgtg  1140
ctgcctaacg aatttatcga gcagtttaag acgggtcagg ccaaagagat cgataccgcg  1200
atttgtgcga aaaccgacgg ttgtaacgag gctcgctggt tctcgctgac aacgcgcaat  1260
gttaatgacg gccagattca gggcgttatt aacaagctgt ggggcgtgga tacgaactat  1320
cagtctgtca gcaagttcca cgtcttccat gactctacca acttctatgg cagcaccggt  1380
aacgcgcgcg gtcaggcggt ggtaaatatc tccaactcgg cattcccgat tctgatggcg  1440
cgtaatgata aaaactactg gctggcgttt ggcgaaaaac gcgcctggga taaaaatgag  1500
ctggcgtaca ttacggaagc gccttccatt gtgcagccag agaacgttac gcgcgatact  1560
gcgactttca acctgccgtt tatttcgctg gggcaagtcg gtgaaggcaa actgatggtt  1620
atcggtaacc cgcactacaa cagcatcctg cgttgcccga acggttacag ttggggcggt  1680
ggtgttaata gtaaaggtga gtgtacgctc agcggtgatt ctgatgacat gaagcacttt  1740
atgcagaacg tactgcgcta cttgtcaaat gacatctggc agccaaatac caagagcatc  1800
atgactgtcg gcaccaacct ggagaacgtt tatttcaaaa aagcgggcca ggtattggga  1860
aatagtgcac catttgcttt ccatgaggat ttcactggta tcacggttaa acagttgacc  1920
agctatggcg atctgaatcc ggaagagatt ccgttgctga tcctcaacgg ctttgaatat  1980
gtgactcagt ggtctggcga tccctatgct gtgcctctgc gtgcagatac cagcaaaccg  2040
aagctgactc agcaggatgt gaccgatctg atcgcttatc tgaacaaagg tggctcggtg  2100
ctgatcatgg aaaacgtgat gagcaatctt aaggaagaga gcgcgtccag ttttgtgcgt  2160
ctgctggatg ccgcgggtct gtcaatggct ctgaacaaat cggtggtgaa caacgatccg  2220
caagggtatc cggatcgcgt tcgtcagcgt cgcgcgactg gcatttgggt ttatgaacgt  2280
tatcctgctg cagacggcgc gcaaccgccg tacaccatcg acccaaatac aggggaagtg  2340
acctggaaat accagcaaga caacaagcct gatgacaagc cgaaactgga agttgcgagc  2400
tggcaggagg aagttgaggg caaacaggta acgcgttatg cctttattga tgaagcggaa  2460
tacacaacag aagaatctct ggaagcggca aaggcaaaaa tctttgagaa gtttcctggg  2520
ttacaggagt gtaaggactc gacttaccat tacgagatta actgtttgga gcgccgccca  2580
ggcacggatg ttccggtaac aggtggcatg tatgttccgc gctatacgca actgaatctt  2640
gacgccgaca ccgcgaaagc gatggtgcag gcggcggatt taggcaccaa cattcagcgc  2700
ctgtatcagc atgagcttta tttccgtacc aaaggcagta aaggtgagcg tctgaacagt  2760
gttgatctgg aacgtctgta ccagaacatg tcggtctggc tgtggaacga tacgaaatat  2820
cgttacgaag agggcaagga agatgagctg ggctttaaaa cgttcaccga gttcctgaac  2880
tgctacgcca atgatgccta tgcaggcggc accaagtgct ccgcagatct gaaaaaatcg  2940
ctggtcgata acaacatgat ctacggtgac ggtagcagca aagcgggcat gatgaaccca  3000
agctatccgc tcaactatat ggaaaaaccg ctgacgcgtc tgatgctggg ccgttcctgg  3060
tgggatctga acattaaggt tgatgtggag aagtacccag gatccgtatc ggcaaagggt  3120
gagagcgtta cggaaaacat cagcctgtac tcgaatccga ccaaatggtt tgcgggtaac  3180
atgcagtcaa ccggcctgtg ggcaccggcc cagcaggacg tcaccattaa gtcttcggcg  3240
tcagtcccag tgactgttac cgtggcgctg gctgacgacc tgactggacg tgagaagcat  3300
gaagttgcgc tgaaccgtcc gccaagagtg actaaaacgt atactctgga ggctaacggt  3360
gaagtgacct tcaaggtgcc ttatggtggt ctgatttata tcaagggcga cagtaaggat  3420
gatgtttctg ctaacttcac ctttaccggt gtagtaaaag cgccgttcta taaagacggc  3480
gaatggaaaa acgatctgga ctcaccggcg ccgctgggcg agctggagtc tgcgtcgttc  3540
gtctatacca cgccgaagaa gaaccttgag gccagcaatt tcactggtgg tgtagcagaa  3600
ttcgctaaag atctggatac ctttgccagc tcgatgaatg acttctacgg tcgtaatgat  3660
gaagacggta agcaccggat gtttacctat aaaaacttga cggggcacaa gcatcgtttc  3720
accaacgatg tgcagatctc catcggtgat gcgcactcgg gttatccggt aatgaacagc  3780
agcttctcga cgaacagcac cacgctgccg acgacgccgc tgaacgactg gctgatttgg  3840
cacgaagtcg gtcataacgc tgcagaaaca ccgctgaacg taccgggtgc aactgaagtg  3900
gcgaacaacg tgctggcgct gtacatgcag gatcgctatc tcggtaagat gaaccgtgtc  3960
gctgacgaca ttaccgtcgc gccggaatat ctggacgaga gcaacggtca ggcctgggcg  4020
cgcggcggtg cgggtgaccg tctgctgatg tacgcacagt tgaaggagtg ggcagaggaa  4080
aactttgata tcaaacagtg gtatccagat ggtgagctgc ctaagttcta cagcgatcgt  4140
aaagggatga agggctggaa cctgttccag ttgatgcacc gtaaagcgcg cggcgatgat  4200
gttggtaaca gcacctttgg tggcaagaat tactgtgctg aatccaatgg taacgctgcc  4260
gacacgctga tgctgtgtgc atcctgggtc gctcaggcgg atctttcgga attctttaag  4320
aaatggaatc cgggtgcaag tgcttaccag ttgccgggag caacggagat gagtttccag  4380
ggcggtgtga gctcttcggc ttacagcacg ctggcgtcac tcaagctgcc gaaaccggaa  4440
aaagggccgg aaaccattaa caaggttacc gagcataaga tgtctgccga g           4491

<210>   18
<211>   1497
<212>   PRT
<213>   Escherichia coli

<400>   18
Cys Asp Gly Gly Gly Ser Gly Ser Ser Ser Asp Thr Pro Ser Val Asp 
1               5                   10                  15      

Ser Gly Ser Gly Thr Leu Pro Glu Val Lys Pro Asp Pro Thr Pro Thr 
            20                  25                  30          

Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp Pro Glu Pro Thr Pro Asp 
        35                  40                  45              

Pro Thr Pro Asp Pro Glu Pro Thr Pro Glu Pro Glu Pro Glu Pro Val 
    50                  55                  60                  

Pro Thr Lys Thr Gly Tyr Leu Thr Leu Gly Gly Ser Gln Arg Val Thr 
65                  70                  75                  80  

Gly Ala Thr Cys Asn Gly Glu Ser Ser Asp Gly Phe Thr Phe Thr Pro 
                85                  90                  95      

Gly Asn Thr Val Ser Cys Val Val Gly Ser Thr Thr Ile Ala Thr Phe 
            100                 105                 110         

Asn Thr Gln Ser Glu Ala Ala Arg Ser Leu Arg Ala Val Asp Lys Val 
        115                 120                 125             

Ser Phe Ser Leu Glu Asp Ala Gln Glu Leu Ala Asn Ser Glu Asn Lys 
    130                 135                 140                 

Lys Thr Asn Ala Ile Ser Leu Val Thr Ser Ser Asp Ser Cys Pro Ala 
145                 150                 155                 160 

Asp Ala Glu Gln Leu Cys Leu Thr Phe Ser Ser Val Val Asp Arg Ala 
                165                 170                 175     

Arg Phe Glu Lys Leu Tyr Lys Gln Ile Asp Leu Ala Thr Asp Asn Phe 
            180                 185                 190         

Ser Lys Leu Val Asn Glu Glu Val Glu Asn Asn Ala Ala Thr Asp Lys 
        195                 200                 205             

Ala Pro Ser Thr His Thr Ser Thr Val Val Pro Val Thr Thr Glu Gly 
    210                 215                 220                 

Thr Lys Pro Asp Leu Asn Ala Ser Phe Val Ser Ala Asn Ala Glu Gln 
225                 230                 235                 240 

Phe Tyr Gln Tyr Gln Pro Thr Glu Ile Ile Leu Ser Glu Gly Gln Leu 
                245                 250                 255     

Val Asp Ser Leu Gly Asn Gly Val Ala Gly Val Asp Tyr Tyr Thr Asn 
            260                 265                 270         

Ser Gly Arg Gly Val Thr Asp Glu Asn Gly Lys Phe Ser Phe Ser Trp 
        275                 280                 285             

Gly Glu Thr Ile Ser Phe Gly Ile Asp Thr Phe Glu Leu Gly Ser Val 
    290                 295                 300                 

Arg Gly Asn Lys Ser Thr Ile Ala Leu Thr Glu Leu Gly Asp Glu Val 
305                 310                 315                 320 

Arg Gly Ala Asn Ile Asp Gln Leu Ile His Arg Tyr Ser Thr Thr Gly 
                325                 330                 335     

Gln Asn Asn Thr Arg Val Val Pro Asp Asp Val Arg Lys Val Phe Ala 
            340                 345                 350         

Glu Tyr Pro Asn Val Ile Asn Glu Ile Ile Asn Leu Ser Leu Ser Asn 
        355                 360                 365             

Gly Ala Thr Leu Asp Glu Gly Asp Gln Asn Val Val Leu Pro Asn Glu 
    370                 375                 380                 

Phe Ile Glu Gln Phe Lys Thr Gly Gln Ala Lys Glu Ile Asp Thr Ala 
385                 390                 395                 400 

Ile Cys Ala Lys Thr Asp Gly Cys Asn Glu Ala Arg Trp Phe Ser Leu 
                405                 410                 415     

Thr Thr Arg Asn Val Asn Asp Gly Gln Ile Gln Gly Val Ile Asn Lys 
            420                 425                 430         

Leu Trp Gly Val Asp Thr Asn Tyr Gln Ser Val Ser Lys Phe His Val 
        435                 440                 445             

Phe His Asp Ser Thr Asn Phe Tyr Gly Ser Thr Gly Asn Ala Arg Gly 
    450                 455                 460                 

Gln Ala Val Val Asn Ile Ser Asn Ser Ala Phe Pro Ile Leu Met Ala 
465                 470                 475                 480 

Arg Asn Asp Lys Asn Tyr Trp Leu Ala Phe Gly Glu Lys Arg Ala Trp 
                485                 490                 495     

Asp Lys Asn Glu Leu Ala Tyr Ile Thr Glu Ala Pro Ser Ile Val Gln 
            500                 505                 510         

Pro Glu Asn Val Thr Arg Asp Thr Ala Thr Phe Asn Leu Pro Phe Ile 
        515                 520                 525             

Ser Leu Gly Gln Val Gly Glu Gly Lys Leu Met Val Ile Gly Asn Pro 
    530                 535                 540                 

His Tyr Asn Ser Ile Leu Arg Cys Pro Asn Gly Tyr Ser Trp Gly Gly 
545                 550                 555                 560 

Gly Val Asn Ser Lys Gly Glu Cys Thr Leu Ser Gly Asp Ser Asp Asp 
                565                 570                 575     

Met Lys His Phe Met Gln Asn Val Leu Arg Tyr Leu Ser Asn Asp Ile 
            580                 585                 590         

Trp Gln Pro Asn Thr Lys Ser Ile Met Thr Val Gly Thr Asn Leu Glu 
        595                 600                 605             

Asn Val Tyr Phe Lys Lys Ala Gly Gln Val Leu Gly Asn Ser Ala Pro 
    610                 615                 620                 

Phe Ala Phe His Glu Asp Phe Thr Gly Ile Thr Val Lys Gln Leu Thr 
625                 630                 635                 640 

Ser Tyr Gly Asp Leu Asn Pro Glu Glu Ile Pro Leu Leu Ile Leu Asn 
                645                 650                 655     

Gly Phe Glu Tyr Val Thr Gln Trp Ser Gly Asp Pro Tyr Ala Val Pro 
            660                 665                 670         

Leu Arg Ala Asp Thr Ser Lys Pro Lys Leu Thr Gln Gln Asp Val Thr 
        675                 680                 685             

Asp Leu Ile Ala Tyr Leu Asn Lys Gly Gly Ser Val Leu Ile Met Glu 
    690                 695                 700                 

Asn Val Met Ser Asn Leu Lys Glu Glu Ser Ala Ser Ser Phe Val Arg 
705                 710                 715                 720 

Leu Leu Asp Ala Ala Gly Leu Ser Met Ala Leu Asn Lys Ser Val Val 
                725                 730                 735     

Asn Asn Asp Pro Gln Gly Tyr Pro Asp Arg Val Arg Gln Arg Arg Ala 
            740                 745                 750         

Thr Gly Ile Trp Val Tyr Glu Arg Tyr Pro Ala Ala Asp Gly Ala Gln 
        755                 760                 765             

Pro Pro Tyr Thr Ile Asp Pro Asn Thr Gly Glu Val Thr Trp Lys Tyr 
    770                 775                 780                 

Gln Gln Asp Asn Lys Pro Asp Asp Lys Pro Lys Leu Glu Val Ala Ser 
785                 790                 795                 800 

Trp Gln Glu Glu Val Glu Gly Lys Gln Val Thr Arg Tyr Ala Phe Ile 
                805                 810                 815     

Asp Glu Ala Glu Tyr Thr Thr Glu Glu Ser Leu Glu Ala Ala Lys Ala 
            820                 825                 830         

Lys Ile Phe Glu Lys Phe Pro Gly Leu Gln Glu Cys Lys Asp Ser Thr 
        835                 840                 845             

Tyr His Tyr Glu Ile Asn Cys Leu Glu Arg Arg Pro Gly Thr Asp Val 
    850                 855                 860                 

Pro Val Thr Gly Gly Met Tyr Val Pro Arg Tyr Thr Gln Leu Asn Leu 
865                 870                 875                 880 

Asp Ala Asp Thr Ala Lys Ala Met Val Gln Ala Ala Asp Leu Gly Thr 
                885                 890                 895     

Asn Ile Gln Arg Leu Tyr Gln His Glu Leu Tyr Phe Arg Thr Lys Gly 
            900                 905                 910         

Ser Lys Gly Glu Arg Leu Asn Ser Val Asp Leu Glu Arg Leu Tyr Gln 
        915                 920                 925             

Asn Met Ser Val Trp Leu Trp Asn Asp Thr Lys Tyr Arg Tyr Glu Glu 
    930                 935                 940                 

Gly Lys Glu Asp Glu Leu Gly Phe Lys Thr Phe Thr Glu Phe Leu Asn 
945                 950                 955                 960 

Cys Tyr Ala Asn Asp Ala Tyr Ala Gly Gly Thr Lys Cys Ser Ala Asp 
                965                 970                 975     

Leu Lys Lys Ser Leu Val Asp Asn Asn Met Ile Tyr Gly Asp Gly Ser 
            980                 985                 990         

Ser Lys Ala Gly Met Met Asn Pro Ser Tyr Pro Leu Asn Tyr Met Glu 
        995                 1000                1005            

Lys Pro Leu Thr Arg Leu Met Leu Gly Arg Ser Trp Trp Asp Leu Asn 
    1010                1015                1020                

Ile Lys Val Asp Val Glu Lys Tyr Pro Gly Ser Val Ser Ala Lys Gly 
1025                1030                1035                1040

Glu Ser Val Thr Glu Asn Ile Ser Leu Tyr Ser Asn Pro Thr Lys Trp 
                1045                1050                1055    

Phe Ala Gly Asn Met Gln Ser Thr Gly Leu Trp Ala Pro Ala Gln Gln 
            1060                1065                1070        

Asp Val Thr Ile Lys Ser Ser Ala Ser Val Pro Val Thr Val Thr Val 
        1075                1080                1085            

Ala Leu Ala Asp Asp Leu Thr Gly Arg Glu Lys His Glu Val Ala Leu 
    1090                1095                1100                

Asn Arg Pro Pro Arg Val Thr Lys Thr Tyr Thr Leu Glu Ala Asn Gly 
1105                1110                1115                1120

Glu Val Thr Phe Lys Val Pro Tyr Gly Gly Leu Ile Tyr Ile Lys Gly 
                1125                1130                1135    

Asp Ser Lys Asp Asp Val Ser Ala Asn Phe Thr Phe Thr Gly Val Val 
            1140                1145                1150        

Lys Ala Pro Phe Tyr Lys Asp Gly Glu Trp Lys Asn Asp Leu Asp Ser 
        1155                1160                1165            

Pro Ala Pro Leu Gly Glu Leu Glu Ser Ala Ser Phe Val Tyr Thr Thr 
    1170                1175                1180                

Pro Lys Lys Asn Leu Glu Ala Ser Asn Phe Thr Gly Gly Val Ala Glu 
1185                1190                1195                1200

Phe Ala Lys Asp Leu Asp Thr Phe Ala Ser Ser Met Asn Asp Phe Tyr 
                1205                1210                1215    

Gly Arg Asn Asp Glu Asp Gly Lys His Arg Met Phe Thr Tyr Lys Asn 
            1220                1225                1230        

Leu Thr Gly His Lys His Arg Phe Thr Asn Asp Val Gln Ile Ser Ile 
        1235                1240                1245            

Gly Asp Ala His Ser Gly Tyr Pro Val Met Asn Ser Ser Phe Ser Thr 
    1250                1255                1260                

Asn Ser Thr Thr Leu Pro Thr Thr Pro Leu Asn Asp Trp Leu Ile Trp 
1265                1270                1275                1280

His Glu Val Gly His Asn Ala Ala Glu Thr Pro Leu Asn Val Pro Gly 
                1285                1290                1295    

Ala Thr Glu Val Ala Asn Asn Val Leu Ala Leu Tyr Met Gln Asp Arg 
            1300                1305                1310        

Tyr Leu Gly Lys Met Asn Arg Val Ala Asp Asp Ile Thr Val Ala Pro 
        1315                1320                1325            

Glu Tyr Leu Asp Glu Ser Asn Gly Gln Ala Trp Ala Arg Gly Gly Ala 
    1330                1335                1340                

Gly Asp Arg Leu Leu Met Tyr Ala Gln Leu Lys Glu Trp Ala Glu Glu 
1345                1350                1355                1360

Asn Phe Asp Ile Lys Gln Trp Tyr Pro Asp Gly Glu Leu Pro Lys Phe 
                1365                1370                1375    

Tyr Ser Asp Arg Lys Gly Met Lys Gly Trp Asn Leu Phe Gln Leu Met 
            1380                1385                1390        

His Arg Lys Ala Arg Gly Asp Asp Val Gly Asn Ser Thr Phe Gly Gly 
        1395                1400                1405            

Lys Asn Tyr Cys Ala Glu Ser Asn Gly Asn Ala Ala Asp Thr Leu Met 
    1410                1415                1420                

Leu Cys Ala Ser Trp Val Ala Gln Ala Asp Leu Ser Glu Phe Phe Lys 
1425                1430                1435                1440

Lys Trp Asn Pro Gly Ala Ser Ala Tyr Gln Leu Pro Gly Ala Thr Glu 
                1445                1450                1455    

Met Ser Phe Gln Gly Gly Val Ser Ser Ser Ala Tyr Ser Thr Leu Ala 
            1460                1465                1470        

Ser Leu Lys Leu Pro Lys Pro Glu Lys Gly Pro Glu Thr Ile Asn Lys 
        1475                1480                1485            

Val Thr Glu His Lys Met Ser Ala Glu 
    1490                1495        

<210>   19
<211>   4491
<212>   DNA
<213>   Escherichia coli

<400>   19
tgtgatggtg gtggttcagg atcgtcctcc gatacgccgt ctgtagattc tggatcaggg  60
actttgccgg aagtgaaacc cgatccaaca ccaaccccgg agccgacacc tgagccgacg  120
ccggacccag aacctacgcc ggatccaaca cctgatcctg agccgacacc agaaccggag  180
ccagaacctg ttcctacgaa aacgggttat ctgaccctgg gcggaagcca gcgggtaact  240
ggtgctacct gtaatggtga atccagcgat ggctttacct ttacgccagg caataccgtg  300
agttgtgtgg tgggcagtac gaccattgca acattcaaca cccagtcaga agctgcgcgt  360
agcctgcgtg cggttgacaa agtgtcgttt agcctggagg acgcgcagga gctggcgaat  420
tctgaaaata agaaaaccaa cgccatctct ctggtgacgt ccagcgacag ttgccccgca  480
gatgcagaac agctttgtct tactttctcg tcagtggttg atcgcgcgcg atttgaaaaa  540
ctgtataagc aaattgatct ggcaacagac aatttcagca agctggtcaa tgaagaggtg  600
gaaaacaatg ctgcgactga taaagcgccg tccacccata cctcaacggt agtgccagtc  660
acgacagagg gaacaaaacc ggatctgaac gcgtccttcg tgtcggctaa cgcggaacag  720
ttttatcagt atcaacccac tgaaatcatt ctttccgaag gccaactggt ggatagcctg  780
gggaacggtg ttgctggcgt tgactactac accaattcag gccgtggcgt aactgacgaa  840
aacggtaaat tttcctttag ctggggcgaa accatctcct ttggtatcga tacctttgaa  900
ctgggctcag tacgtggcaa taagtcgacc attgcgctga ctgaattggg tgatgaagtt  960
cgcggggcaa atatcgatca gctcattcat cgttattcga cgactggtca aaataatact  1020
cgtgttgttc cggacgatgt acgcaaggtc tttgccgaat atcccaacgt gatcaacgag  1080
ataatcaatc tttcgttatc caacggtgcg acgctggatg aaggcgatca aaacgttgtg  1140
ctgcctaacg aatttatcga gcagtttaag acgggtcagg ccaaagagat cgataccgcg  1200
atttgtgcga aaaccgacgg ttgtaacgag gctcgctggt tctcgctgac aacgcgcaat  1260
gttaatgacg gccagattca gggcgttatt aacaagctgt ggggcgtgga tacgaactat  1320
cagtctgtca gcaagttcca cgtcttccat gactctacca acttctatgg cagcaccggt  1380
aacgcgcgcg gtcaggcggt ggtaaatatc tccaactcgg cattcccgat tctgatggcg  1440
cgtaatgata aaaactactg gctggcgttt ggcgaaaaac gcgcctggga taaaaatgag  1500
ctggcgtaca ttacggaagc gccttccatt gtgcagccag agaacgttac gcgcgatact  1560
gcgactttca acctgccgtt tatttcgctg gggcaagtcg gtgaaggcaa actgatggtt  1620
atcggtaacc cgcactacaa cagcatcctg cgttgcccga acggttacag ttggggcggt  1680
ggtgttaata gtaaaggtga gtgtacgctc agcggtgatt ctgatgacat gaagcacttt  1740
atgcagaacg tactgcgcta cttgtcaaat gacatctggc agccaaatac caagagcatc  1800
atgactgtcg gcaccaacct ggagaacgtt tatttcaaaa aagcgggcca ggtattggga  1860
aatagtgcac catttgcttt ccatgaggat ttcactggta tcacggttaa acagttgacc  1920
agctatggcg atctgaatcc ggaagagatt ccgttgctga tcctcaacgg ctttgaatat  1980
gtgactcagt ggtctggcga tccctatgct gtgcctctgc gtgcagatac cagcaaaccg  2040
aagctgactc agcaggatgt gaccgatctg atcgcttatc tgaacaaagg tggctcggtg  2100
ctgatcatgg aaaacgtgat gagcaatctt aaggaagaga gcgcgtccag ttttgtgcgt  2160
ctgctggatg ccgcgggtct gtcaatggct ctgaacaaat cggtggtgaa caacgatccg  2220
caagggtatc cggatcgcgt tcgtcagcgt cgcgcgactg gcatttgggt ttatgaacgt  2280
tatcctgctg cagacggcgc gcaaccgccg tacaccatcg acccaaatac aggggaagtg  2340
acctggaaat accagcaaga caacaagcct gatgacaagc cgaaactgga agttgcgagc  2400
tggcaggagg aagttgaggg caaacaggta acgcgttatg cctttattga tgaagcggaa  2460
tacacaacag aagaatctct ggaagcggca aaggcaaaaa tctttgagaa gtttcctggg  2520
ttacaggagt gtaaggactc gacttaccat tacgagatta actgtttgga gcgccgccca  2580
ggcacggatg ttccggtaac aggtggcatg tatgttccgc gctatacgca actgaatctt  2640
gacgccgaca ccgcgaaagc gatggtgcag gcggcggatt taggcaccaa cattcagcgc  2700
ctgtatcagc atgagcttta tttccgtacc aaaggcagta aaggtgagcg tctgaacagt  2760
gttgatctgg aacgtctgta ccagaacatg tcggtctggc tgtggaacga tacgaaatat  2820
cgttacgaag agggcaagga agatgagctg ggctttaaaa cgttcaccga gttcctgaac  2880
tgctacgcca atgatgccta tgcaggcggc accaagtgct ccgcagatct gaaaaaatcg  2940
ctggtcgata acaacatgat ctacggtgac ggtagcagca aagcgggcat gatgaaccca  3000
agctatccgc tcaactatat ggaaaaaccg ctgacgcgtc tgatgctggg ccgttcctgg  3060
tgggatctga acattaaggt tgatgtggag aagtacccag gatccgtatc ggcaaagggt  3120
gagagcgtta cggaaaacat cagcctgtac tcgaatccga ccaaatggtt tgcgggtaac  3180
atgcagtcaa ccggcctgtg ggcaccggcc cagcaggacg tcaccattaa gtcttcggcg  3240
tcagtcccag tgactgttac cgtggcgctg gctgacgacc tgactggacg tgagaagcat  3300
gaagttgcgc tgaaccgtcc gccaagagtg actaaaacgt atactctgga ggctaacggt  3360
gaagtgacct tcaaggtgcc ttatggtggt ctgatttata tcaagggcga cagtaaggat  3420
gatgtttctg ctaacttcac ctttaccggt gtagtaaaag cgccgttcta taaagacggc  3480
gaatggaaaa acgatctgga ctcaccggcg ccgctgggcg agctggagtc tgcgtcgttc  3540
gtctatacca cgccgaagaa gaaccttgag gccagcaatt tcactggtgg tgtagcagaa  3600
ttcgctaaag atctggatac ctttgccagc tcgatgaatg acttctacgg tcgtaatgat  3660
gaagacggta agcaccggat gtttacctat aaaaacttga cggggcacaa gcatcgtttc  3720
accaacgatg tgcagatctc catcggtgat gcgcactcgg gttatccggt aatgaacagc  3780
agcttctcga cgaacagcac cacgctgccg acgacgccgc tgaacgactg gctgatttgg  3840
cacgcagtcg gtcataacgc tgcagaaaca ccgctgaacg taccgggtgc aactgaagtg  3900
gcgaacaacg tgctggcgct gtacatgcag gatcgctatc tcggtaagat gaaccgtgtc  3960
gctgacgaca ttaccgtcgc gccggaatat ctggacgaga gcaacggtca ggcctgggcg  4020
cgcggcggtg cgggtgaccg tctgctgatg tacgcacagt tgaaggagtg ggcagaggaa  4080
aactttgata tcaaacagtg gtatccagat ggtgagctgc ctaagttcta cagcgatcgt  4140
aaagggatga agggctggaa cctgttccag ttgatgcacc gtaaagcgcg cggcgatgat  4200
gttggtaaca gcacctttgg tggcaagaat tactgtgctg aatccaatgg taacgctgcc  4260
gacacgctga tgctgtgtgc atcctgggtc gctcaggcgg atctttcgga attctttaag  4320
aaatggaatc cgggtgcaag tgcttaccag ttgccgggag caacggagat gagtttccag  4380
ggcggtgtga gctcttcggc ttacagcacg ctggcgtcac tcaagctgcc gaaaccggaa  4440
aaagggccgg aaaccattaa caaggttacc gagcataaga tgtctgccga g           4491

<210>   20
<211>   1497
<212>   PRT
<213>   Escherichia coli

<400>   20
Cys Asp Gly Gly Gly Ser Gly Ser Ser Ser Asp Thr Pro Ser Val Asp 
1               5                   10                  15      

Ser Gly Ser Gly Thr Leu Pro Glu Val Lys Pro Asp Pro Thr Pro Thr 
            20                  25                  30          

Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp Pro Glu Pro Thr Pro Asp 
        35                  40                  45              

Pro Thr Pro Asp Pro Glu Pro Thr Pro Glu Pro Glu Pro Glu Pro Val 
    50                  55                  60                  

Pro Thr Lys Thr Gly Tyr Leu Thr Leu Gly Gly Ser Gln Arg Val Thr 
65                  70                  75                  80  

Gly Ala Thr Cys Asn Gly Glu Ser Ser Asp Gly Phe Thr Phe Thr Pro 
                85                  90                  95      

Gly Asn Thr Val Ser Cys Val Val Gly Ser Thr Thr Ile Ala Thr Phe 
            100                 105                 110         

Asn Thr Gln Ser Glu Ala Ala Arg Ser Leu Arg Ala Val Asp Lys Val 
        115                 120                 125             

Ser Phe Ser Leu Glu Asp Ala Gln Glu Leu Ala Asn Ser Glu Asn Lys 
    130                 135                 140                 

Lys Thr Asn Ala Ile Ser Leu Val Thr Ser Ser Asp Ser Cys Pro Ala 
145                 150                 155                 160 

Asp Ala Glu Gln Leu Cys Leu Thr Phe Ser Ser Val Val Asp Arg Ala 
                165                 170                 175     

Arg Phe Glu Lys Leu Tyr Lys Gln Ile Asp Leu Ala Thr Asp Asn Phe 
            180                 185                 190         

Ser Lys Leu Val Asn Glu Glu Val Glu Asn Asn Ala Ala Thr Asp Lys 
        195                 200                 205             

Ala Pro Ser Thr His Thr Ser Thr Val Val Pro Val Thr Thr Glu Gly 
    210                 215                 220                 

Thr Lys Pro Asp Leu Asn Ala Ser Phe Val Ser Ala Asn Ala Glu Gln 
225                 230                 235                 240 

Phe Tyr Gln Tyr Gln Pro Thr Glu Ile Ile Leu Ser Glu Gly Gln Leu 
                245                 250                 255     

Val Asp Ser Leu Gly Asn Gly Val Ala Gly Val Asp Tyr Tyr Thr Asn 
            260                 265                 270         

Ser Gly Arg Gly Val Thr Asp Glu Asn Gly Lys Phe Ser Phe Ser Trp 
        275                 280                 285             

Gly Glu Thr Ile Ser Phe Gly Ile Asp Thr Phe Glu Leu Gly Ser Val 
    290                 295                 300                 

Arg Gly Asn Lys Ser Thr Ile Ala Leu Thr Glu Leu Gly Asp Glu Val 
305                 310                 315                 320 

Arg Gly Ala Asn Ile Asp Gln Leu Ile His Arg Tyr Ser Thr Thr Gly 
                325                 330                 335     

Gln Asn Asn Thr Arg Val Val Pro Asp Asp Val Arg Lys Val Phe Ala 
            340                 345                 350         

Glu Tyr Pro Asn Val Ile Asn Glu Ile Ile Asn Leu Ser Leu Ser Asn 
        355                 360                 365             

Gly Ala Thr Leu Asp Glu Gly Asp Gln Asn Val Val Leu Pro Asn Glu 
    370                 375                 380                 

Phe Ile Glu Gln Phe Lys Thr Gly Gln Ala Lys Glu Ile Asp Thr Ala 
385                 390                 395                 400 

Ile Cys Ala Lys Thr Asp Gly Cys Asn Glu Ala Arg Trp Phe Ser Leu 
                405                 410                 415     

Thr Thr Arg Asn Val Asn Asp Gly Gln Ile Gln Gly Val Ile Asn Lys 
            420                 425                 430         

Leu Trp Gly Val Asp Thr Asn Tyr Gln Ser Val Ser Lys Phe His Val 
        435                 440                 445             

Phe His Asp Ser Thr Asn Phe Tyr Gly Ser Thr Gly Asn Ala Arg Gly 
    450                 455                 460                 

Gln Ala Val Val Asn Ile Ser Asn Ser Ala Phe Pro Ile Leu Met Ala 
465                 470                 475                 480 

Arg Asn Asp Lys Asn Tyr Trp Leu Ala Phe Gly Glu Lys Arg Ala Trp 
                485                 490                 495     

Asp Lys Asn Glu Leu Ala Tyr Ile Thr Glu Ala Pro Ser Ile Val Gln 
            500                 505                 510         

Pro Glu Asn Val Thr Arg Asp Thr Ala Thr Phe Asn Leu Pro Phe Ile 
        515                 520                 525             

Ser Leu Gly Gln Val Gly Glu Gly Lys Leu Met Val Ile Gly Asn Pro 
    530                 535                 540                 

His Tyr Asn Ser Ile Leu Arg Cys Pro Asn Gly Tyr Ser Trp Gly Gly 
545                 550                 555                 560 

Gly Val Asn Ser Lys Gly Glu Cys Thr Leu Ser Gly Asp Ser Asp Asp 
                565                 570                 575     

Met Lys His Phe Met Gln Asn Val Leu Arg Tyr Leu Ser Asn Asp Ile 
            580                 585                 590         

Trp Gln Pro Asn Thr Lys Ser Ile Met Thr Val Gly Thr Asn Leu Glu 
        595                 600                 605             

Asn Val Tyr Phe Lys Lys Ala Gly Gln Val Leu Gly Asn Ser Ala Pro 
    610                 615                 620                 

Phe Ala Phe His Glu Asp Phe Thr Gly Ile Thr Val Lys Gln Leu Thr 
625                 630                 635                 640 

Ser Tyr Gly Asp Leu Asn Pro Glu Glu Ile Pro Leu Leu Ile Leu Asn 
                645                 650                 655     

Gly Phe Glu Tyr Val Thr Gln Trp Ser Gly Asp Pro Tyr Ala Val Pro 
            660                 665                 670         

Leu Arg Ala Asp Thr Ser Lys Pro Lys Leu Thr Gln Gln Asp Val Thr 
        675                 680                 685             

Asp Leu Ile Ala Tyr Leu Asn Lys Gly Gly Ser Val Leu Ile Met Glu 
    690                 695                 700                 

Asn Val Met Ser Asn Leu Lys Glu Glu Ser Ala Ser Ser Phe Val Arg 
705                 710                 715                 720 

Leu Leu Asp Ala Ala Gly Leu Ser Met Ala Leu Asn Lys Ser Val Val 
                725                 730                 735     

Asn Asn Asp Pro Gln Gly Tyr Pro Asp Arg Val Arg Gln Arg Arg Ala 
            740                 745                 750         

Thr Gly Ile Trp Val Tyr Glu Arg Tyr Pro Ala Ala Asp Gly Ala Gln 
        755                 760                 765             

Pro Pro Tyr Thr Ile Asp Pro Asn Thr Gly Glu Val Thr Trp Lys Tyr 
    770                 775                 780                 

Gln Gln Asp Asn Lys Pro Asp Asp Lys Pro Lys Leu Glu Val Ala Ser 
785                 790                 795                 800 

Trp Gln Glu Glu Val Glu Gly Lys Gln Val Thr Arg Tyr Ala Phe Ile 
                805                 810                 815     

Asp Glu Ala Glu Tyr Thr Thr Glu Glu Ser Leu Glu Ala Ala Lys Ala 
            820                 825                 830         

Lys Ile Phe Glu Lys Phe Pro Gly Leu Gln Glu Cys Lys Asp Ser Thr 
        835                 840                 845             

Tyr His Tyr Glu Ile Asn Cys Leu Glu Arg Arg Pro Gly Thr Asp Val 
    850                 855                 860                 

Pro Val Thr Gly Gly Met Tyr Val Pro Arg Tyr Thr Gln Leu Asn Leu 
865                 870                 875                 880 

Asp Ala Asp Thr Ala Lys Ala Met Val Gln Ala Ala Asp Leu Gly Thr 
                885                 890                 895     

Asn Ile Gln Arg Leu Tyr Gln His Glu Leu Tyr Phe Arg Thr Lys Gly 
            900                 905                 910         

Ser Lys Gly Glu Arg Leu Asn Ser Val Asp Leu Glu Arg Leu Tyr Gln 
        915                 920                 925             

Asn Met Ser Val Trp Leu Trp Asn Asp Thr Lys Tyr Arg Tyr Glu Glu 
    930                 935                 940                 

Gly Lys Glu Asp Glu Leu Gly Phe Lys Thr Phe Thr Glu Phe Leu Asn 
945                 950                 955                 960 

Cys Tyr Ala Asn Asp Ala Tyr Ala Gly Gly Thr Lys Cys Ser Ala Asp 
                965                 970                 975     

Leu Lys Lys Ser Leu Val Asp Asn Asn Met Ile Tyr Gly Asp Gly Ser 
            980                 985                 990         

Ser Lys Ala Gly Met Met Asn Pro Ser Tyr Pro Leu Asn Tyr Met Glu 
        995                 1000                1005            

Lys Pro Leu Thr Arg Leu Met Leu Gly Arg Ser Trp Trp Asp Leu Asn 
    1010                1015                1020                

Ile Lys Val Asp Val Glu Lys Tyr Pro Gly Ser Val Ser Ala Lys Gly 
1025                1030                1035                1040

Glu Ser Val Thr Glu Asn Ile Ser Leu Tyr Ser Asn Pro Thr Lys Trp 
                1045                1050                1055    

Phe Ala Gly Asn Met Gln Ser Thr Gly Leu Trp Ala Pro Ala Gln Gln 
            1060                1065                1070        

Asp Val Thr Ile Lys Ser Ser Ala Ser Val Pro Val Thr Val Thr Val 
        1075                1080                1085            

Ala Leu Ala Asp Asp Leu Thr Gly Arg Glu Lys His Glu Val Ala Leu 
    1090                1095                1100                

Asn Arg Pro Pro Arg Val Thr Lys Thr Tyr Thr Leu Glu Ala Asn Gly 
1105                1110                1115                1120

Glu Val Thr Phe Lys Val Pro Tyr Gly Gly Leu Ile Tyr Ile Lys Gly 
                1125                1130                1135    

Asp Ser Lys Asp Asp Val Ser Ala Asn Phe Thr Phe Thr Gly Val Val 
            1140                1145                1150        

Lys Ala Pro Phe Tyr Lys Asp Gly Glu Trp Lys Asn Asp Leu Asp Ser 
        1155                1160                1165            

Pro Ala Pro Leu Gly Glu Leu Glu Ser Ala Ser Phe Val Tyr Thr Thr 
    1170                1175                1180                

Pro Lys Lys Asn Leu Glu Ala Ser Asn Phe Thr Gly Gly Val Ala Glu 
1185                1190                1195                1200

Phe Ala Lys Asp Leu Asp Thr Phe Ala Ser Ser Met Asn Asp Phe Tyr 
                1205                1210                1215    

Gly Arg Asn Asp Glu Asp Gly Lys His Arg Met Phe Thr Tyr Lys Asn 
            1220                1225                1230        

Leu Thr Gly His Lys His Arg Phe Thr Asn Asp Val Gln Ile Ser Ile 
        1235                1240                1245            

Gly Asp Ala His Ser Gly Tyr Pro Val Met Asn Ser Ser Phe Ser Thr 
    1250                1255                1260                

Asn Ser Thr Thr Leu Pro Thr Thr Pro Leu Asn Asp Trp Leu Ile Trp 
1265                1270                1275                1280

His Ala Val Gly His Asn Ala Ala Glu Thr Pro Leu Asn Val Pro Gly 
                1285                1290                1295    

Ala Thr Glu Val Ala Asn Asn Val Leu Ala Leu Tyr Met Gln Asp Arg 
            1300                1305                1310        

Tyr Leu Gly Lys Met Asn Arg Val Ala Asp Asp Ile Thr Val Ala Pro 
        1315                1320                1325            

Glu Tyr Leu Asp Glu Ser Asn Gly Gln Ala Trp Ala Arg Gly Gly Ala 
    1330                1335                1340                

Gly Asp Arg Leu Leu Met Tyr Ala Gln Leu Lys Glu Trp Ala Glu Glu 
1345                1350                1355                1360

Asn Phe Asp Ile Lys Gln Trp Tyr Pro Asp Gly Glu Leu Pro Lys Phe 
                1365                1370                1375    

Tyr Ser Asp Arg Lys Gly Met Lys Gly Trp Asn Leu Phe Gln Leu Met 
            1380                1385                1390        

His Arg Lys Ala Arg Gly Asp Asp Val Gly Asn Ser Thr Phe Gly Gly 
        1395                1400                1405            

Lys Asn Tyr Cys Ala Glu Ser Asn Gly Asn Ala Ala Asp Thr Leu Met 
    1410                1415                1420                

Leu Cys Ala Ser Trp Val Ala Gln Ala Asp Leu Ser Glu Phe Phe Lys 
1425                1430                1435                1440

Lys Trp Asn Pro Gly Ala Ser Ala Tyr Gln Leu Pro Gly Ala Thr Glu 
                1445                1450                1455    

Met Ser Phe Gln Gly Gly Val Ser Ser Ser Ala Tyr Ser Thr Leu Ala 
            1460                1465                1470        

Ser Leu Lys Leu Pro Lys Pro Glu Lys Gly Pro Glu Thr Ile Asn Lys 
        1475                1480                1485            

Val Thr Glu His Lys Met Ser Ala Glu 
    1490                1495        

<210>   21
<211>   4491
<212>   DNA
<213>   Escherichia coli

<400>   21
tgtgatggtg gtggttcagg atcgtcctcc gatacgccgt ctgtagattc tggatcaggg  60
actttgccgg aagtgaaacc cgatccaaca ccaaccccgg agccgacacc tgagccgacg  120
ccggacccag aacctacgcc ggatccaaca cctgatcctg agccgacacc agaaccggag  180
ccagaacctg ttcctacgaa aacgggttat ctgaccctgg gcggaagcca gcgggtaact  240
ggtgctacct gtaatggtga atccagcgat ggctttacct ttacgccagg caataccgtg  300
agttgtgtgg tgggcagtac gaccattgca acattcaaca cccagtcaga agctgcgcgt  360
agcctgcgtg cggttgacaa agtgtcgttt agcctggagg acgcgcagga gctggcgaat  420
tctgaaaata agaaaaccaa cgccatctct ctggtgacgt ccagcgacag ttgccccgca  480
gatgcagaac agctttgtct tactttctcg tcagtggttg atcgcgcgcg atttgaaaaa  540
ctgtataagc aaattgatct ggcaacagac aatttcagca agctggtcaa tgaagaggtg  600
gaaaacaatg ctgcgactga taaagcgccg tccacccata cctcaacggt agtgccagtc  660
acgacagagg gaacaaaacc ggatctgaac gcgtccttcg tgtcggctaa cgcggaacag  720
ttttatcagt atcaacccac tgaaatcatt ctttccgaag gccaactggt ggatagcctg  780
gggaacggtg ttgctggcgt tgactactac accaattcag gccgtggcgt aactgacgaa  840
aacggtaaat tttcctttag ctggggcgaa accatctcct ttggtatcga tacctttgaa  900
ctgggctcag tacgtggcaa taagtcgacc attgcgctga ctgaattggg tgatgaagtt  960
cgcggggcaa atatcgatca gctcattcat cgttattcga cgactggtca aaataatact  1020
cgtgttgttc cggacgatgt acgcaaggtc tttgccgaat atcccaacgt gatcaacgag  1080
ataatcaatc tttcgttatc caacggtgcg acgctggatg aaggcgatca aaacgttgtg  1140
ctgcctaacg aatttatcga gcagtttaag acgggtcagg ccaaagagat cgataccgcg  1200
atttgtgcga aaaccgacgg ttgtaacgag gctcgctggt tctcgctgac aacgcgcaat  1260
gttaatgacg gccagattca gggcgttatt aacaagctgt ggggcgtgga tacgaactat  1320
cagtctgtca gcaagttcca cgtcttccat gactctacca acttctatgg cagcaccggt  1380
aacgcgcgcg gtcaggcggt ggtaaatatc tccaactcgg cattcccgat tctgatggcg  1440
cgtaatgata aaaactactg gctggcgttt ggcgaaaaac gcgcctggga taaaaatgag  1500
ctggcgtaca ttacggaagc gccttccatt gtgcagccag agaacgttac gcgcgatact  1560
gcgactttca acctgccgtt tatttcgctg gggcaagtcg gtgaaggcaa actgatggtt  1620
atcggtaacc cgcactacaa cagcatcctg cgttgcccga acggttacag ttggggcggt  1680
ggtgttaata gtaaaggtga gtgtacgctc agcggtgatt ctgatgacat gaagcacttt  1740
atgcagaacg tactgcgcta cttgtcaaat gacatctggc agccaaatac caagagcatc  1800
atgactgtcg gcaccaacct ggagaacgtt tatttcaaaa aagcgggcca ggtattggga  1860
aatagtgcac catttgcttt ccatgaggat ttcactggta tcacggttaa acagttgacc  1920
agctatggcg atctgaatcc ggaagagatt ccgttgctga tcctcaacgg ctttgaatat  1980
gtgactcagt ggtctggcga tccctatgct gtgcctctgc gtgcagatac cagcaaaccg  2040
aagctgactc agcaggatgt gaccgatctg atcgcttatc tgaacaaagg tggctcggtg  2100
ctgatcatgg aaaacgtgat gagcaatctt aaggaagaga gcgcgtccag ttttgtgcgt  2160
ctgctggatg ccgcgggtct gtcaatggct ctgaacaaat cggtggtgaa caacgatccg  2220
caagggtatc cggatcgcgt tcgtcagcgt cgcgcgactg gcatttgggt ttatgaacgt  2280
tatcctgctg cagacggcgc gcaaccgccg tacaccatcg acccaaatac aggggaagtg  2340
acctggaaat accagcaaga caacaagcct gatgacaagc cgaaactgga agttgcgagc  2400
tggcaggagg aagttgaggg caaacaggta acgcgttatg cctttattga tgaagcggaa  2460
tacacaacag aagaatctct ggaagcggca aaggcaaaaa tctttgagaa gtttcctggg  2520
ttacaggagt gtaaggactc gacttaccat tacgagatta actgtttgga gcgccgccca  2580
ggcacggatg ttccggtaac aggtggcatg tatgttccgc gctatacgca actgaatctt  2640
gacgccgaca ccgcgaaagc gatggtgcag gcggcggatt taggcaccaa cattcagcgc  2700
ctgtatcagc atgagcttta tttccgtacc aaaggcagta aaggtgagcg tctgaacagt  2760
gttgatctgg aacgtctgta ccagaacatg tcggtctggc tgtggaacga tacgaaatat  2820
cgttacgaag agggcaagga agatgagctg ggctttaaaa cgttcaccga gttcctgaac  2880
tgctacgcca atgatgccta tgcaggcggc accaagtgct ccgcagatct gaaaaaatcg  2940
ctggtcgata acaacatgat ctacggtgac ggtagcagca aagcgggcat gatgaaccca  3000
agctatccgc tcaactatat ggaaaaaccg ctgacgcgtc tgatgctggg ccgttcctgg  3060
tgggatctga acattaaggt tgatgtggag aagtacccag gatccgtatc ggcaaagggt  3120
gagagcgtta cggaaaacat cagcctgtac tcgaatccga ccaaatggtt tgcgggtaac  3180
atgcagtcaa ccggcctgtg ggcaccggcc cagcaggacg tcaccattaa gtcttcggcg  3240
tcagtcccag tgactgttac cgtggcgctg gctgacgacc tgactggacg tgagaagcat  3300
gaagttgcgc tgaaccgtcc gccaagagtg actaaaacgt atactctgga ggctaacggt  3360
gaagtgacct tcaaggtgcc ttatggtggt ctgatttata tcaagggcga cagtaaggat  3420
gatgtttctg ctaacttcac ctttaccggt gtagtaaaag cgccgttcta taaagacggc  3480
gaatggaaaa acgatctgga ctcaccggcg ccgctgggcg agctggagtc tgcgtcgttc  3540
gtctatacca cgccgaagaa gaaccttgag gccagcaatt tcactggtgg tgtagcagaa  3600
ttcgctaaag atctggatac ctttgccagc tcgatgaatg acttctacgg tcgtaatgat  3660
gaagacggta agcaccggat gtttacctat aaaaacttga cggggcacaa gcatcgtttc  3720
accaacgatg tgcagatctc catcggtgat gcgcactcgg gttatccggt aatgaacagc  3780
agcttctcga cgaacagcac cacgctgccg acgacgccgc tgaacgactg gctgatttgg  3840
cacgaagtcg gtcataacgc tgcagaaaca ccgctgaacg taccgggtgc aactgaagtg  3900
gcgaacaacg tgctggcgct gtacatgcag gatcgctatc tcggtaagat gaaccgtgtc  3960
gctgacgaca ttaccgtcgc gccggaatat ctggacgaga gcaacggtca ggcctgggcg  4020
cgcggcggtg cgggtgaccg tctgctgatg tacgcacagt tgaaggagtg ggcagaggaa  4080
aactttgata tcaaacagtg gtatccagat ggtgagctgc ctaagttcta cagcgatcgt  4140
aaagggatga agggctggaa cctgttccag ttgatgcacc gtaaagcgcg cggcgctgat  4200
gttggtaaca gcacctttgg tggcaagaat tactgtgctg aatccaatgg taacgctgcc  4260
gacacgctga tgctgtgtgc atcctgggtc gctcaggcgg atctttcgga attctttaag  4320
aaatggaatc cgggtgcaag tgcttaccag ttgccgggag caacggagat gagtttccag  4380
ggcggtgtga gctcttcggc ttacagcacg ctggcgtcac tcaagctgcc gaaaccggaa  4440
aaagggccgg aaaccattaa caaggttacc gagcataaga tgtctgccga g           4491

<210>   22
<211>   1497
<212>   PRT
<213>   Escherichia coli

<400>   22
Cys Asp Gly Gly Gly Ser Gly Ser Ser Ser Asp Thr Pro Ser Val Asp 
1               5                   10                  15      

Ser Gly Ser Gly Thr Leu Pro Glu Val Lys Pro Asp Pro Thr Pro Thr 
            20                  25                  30          

Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp Pro Glu Pro Thr Pro Asp 
        35                  40                  45              

Pro Thr Pro Asp Pro Glu Pro Thr Pro Glu Pro Glu Pro Glu Pro Val 
    50                  55                  60                  

Pro Thr Lys Thr Gly Tyr Leu Thr Leu Gly Gly Ser Gln Arg Val Thr 
65                  70                  75                  80  

Gly Ala Thr Cys Asn Gly Glu Ser Ser Asp Gly Phe Thr Phe Thr Pro 
                85                  90                  95      

Gly Asn Thr Val Ser Cys Val Val Gly Ser Thr Thr Ile Ala Thr Phe 
            100                 105                 110         

Asn Thr Gln Ser Glu Ala Ala Arg Ser Leu Arg Ala Val Asp Lys Val 
        115                 120                 125             

Ser Phe Ser Leu Glu Asp Ala Gln Glu Leu Ala Asn Ser Glu Asn Lys 
    130                 135                 140                 

Lys Thr Asn Ala Ile Ser Leu Val Thr Ser Ser Asp Ser Cys Pro Ala 
145                 150                 155                 160 

Asp Ala Glu Gln Leu Cys Leu Thr Phe Ser Ser Val Val Asp Arg Ala 
                165                 170                 175     

Arg Phe Glu Lys Leu Tyr Lys Gln Ile Asp Leu Ala Thr Asp Asn Phe 
            180                 185                 190         

Ser Lys Leu Val Asn Glu Glu Val Glu Asn Asn Ala Ala Thr Asp Lys 
        195                 200                 205             

Ala Pro Ser Thr His Thr Ser Thr Val Val Pro Val Thr Thr Glu Gly 
    210                 215                 220                 

Thr Lys Pro Asp Leu Asn Ala Ser Phe Val Ser Ala Asn Ala Glu Gln 
225                 230                 235                 240 

Phe Tyr Gln Tyr Gln Pro Thr Glu Ile Ile Leu Ser Glu Gly Gln Leu 
                245                 250                 255     

Val Asp Ser Leu Gly Asn Gly Val Ala Gly Val Asp Tyr Tyr Thr Asn 
            260                 265                 270         

Ser Gly Arg Gly Val Thr Asp Glu Asn Gly Lys Phe Ser Phe Ser Trp 
        275                 280                 285             

Gly Glu Thr Ile Ser Phe Gly Ile Asp Thr Phe Glu Leu Gly Ser Val 
    290                 295                 300                 

Arg Gly Asn Lys Ser Thr Ile Ala Leu Thr Glu Leu Gly Asp Glu Val 
305                 310                 315                 320 

Arg Gly Ala Asn Ile Asp Gln Leu Ile His Arg Tyr Ser Thr Thr Gly 
                325                 330                 335     

Gln Asn Asn Thr Arg Val Val Pro Asp Asp Val Arg Lys Val Phe Ala 
            340                 345                 350         

Glu Tyr Pro Asn Val Ile Asn Glu Ile Ile Asn Leu Ser Leu Ser Asn 
        355                 360                 365             

Gly Ala Thr Leu Asp Glu Gly Asp Gln Asn Val Val Leu Pro Asn Glu 
    370                 375                 380                 

Phe Ile Glu Gln Phe Lys Thr Gly Gln Ala Lys Glu Ile Asp Thr Ala 
385                 390                 395                 400 

Ile Cys Ala Lys Thr Asp Gly Cys Asn Glu Ala Arg Trp Phe Ser Leu 
                405                 410                 415     

Thr Thr Arg Asn Val Asn Asp Gly Gln Ile Gln Gly Val Ile Asn Lys 
            420                 425                 430         

Leu Trp Gly Val Asp Thr Asn Tyr Gln Ser Val Ser Lys Phe His Val 
        435                 440                 445             

Phe His Asp Ser Thr Asn Phe Tyr Gly Ser Thr Gly Asn Ala Arg Gly 
    450                 455                 460                 

Gln Ala Val Val Asn Ile Ser Asn Ser Ala Phe Pro Ile Leu Met Ala 
465                 470                 475                 480 

Arg Asn Asp Lys Asn Tyr Trp Leu Ala Phe Gly Glu Lys Arg Ala Trp 
                485                 490                 495     

Asp Lys Asn Glu Leu Ala Tyr Ile Thr Glu Ala Pro Ser Ile Val Gln 
            500                 505                 510         

Pro Glu Asn Val Thr Arg Asp Thr Ala Thr Phe Asn Leu Pro Phe Ile 
        515                 520                 525             

Ser Leu Gly Gln Val Gly Glu Gly Lys Leu Met Val Ile Gly Asn Pro 
    530                 535                 540                 

His Tyr Asn Ser Ile Leu Arg Cys Pro Asn Gly Tyr Ser Trp Gly Gly 
545                 550                 555                 560 

Gly Val Asn Ser Lys Gly Glu Cys Thr Leu Ser Gly Asp Ser Asp Asp 
                565                 570                 575     

Met Lys His Phe Met Gln Asn Val Leu Arg Tyr Leu Ser Asn Asp Ile 
            580                 585                 590         

Trp Gln Pro Asn Thr Lys Ser Ile Met Thr Val Gly Thr Asn Leu Glu 
        595                 600                 605             

Asn Val Tyr Phe Lys Lys Ala Gly Gln Val Leu Gly Asn Ser Ala Pro 
    610                 615                 620                 

Phe Ala Phe His Glu Asp Phe Thr Gly Ile Thr Val Lys Gln Leu Thr 
625                 630                 635                 640 

Ser Tyr Gly Asp Leu Asn Pro Glu Glu Ile Pro Leu Leu Ile Leu Asn 
                645                 650                 655     

Gly Phe Glu Tyr Val Thr Gln Trp Ser Gly Asp Pro Tyr Ala Val Pro 
            660                 665                 670         

Leu Arg Ala Asp Thr Ser Lys Pro Lys Leu Thr Gln Gln Asp Val Thr 
        675                 680                 685             

Asp Leu Ile Ala Tyr Leu Asn Lys Gly Gly Ser Val Leu Ile Met Glu 
    690                 695                 700                 

Asn Val Met Ser Asn Leu Lys Glu Glu Ser Ala Ser Ser Phe Val Arg 
705                 710                 715                 720 

Leu Leu Asp Ala Ala Gly Leu Ser Met Ala Leu Asn Lys Ser Val Val 
                725                 730                 735     

Asn Asn Asp Pro Gln Gly Tyr Pro Asp Arg Val Arg Gln Arg Arg Ala 
            740                 745                 750         

Thr Gly Ile Trp Val Tyr Glu Arg Tyr Pro Ala Ala Asp Gly Ala Gln 
        755                 760                 765             

Pro Pro Tyr Thr Ile Asp Pro Asn Thr Gly Glu Val Thr Trp Lys Tyr 
    770                 775                 780                 

Gln Gln Asp Asn Lys Pro Asp Asp Lys Pro Lys Leu Glu Val Ala Ser 
785                 790                 795                 800 

Trp Gln Glu Glu Val Glu Gly Lys Gln Val Thr Arg Tyr Ala Phe Ile 
                805                 810                 815     

Asp Glu Ala Glu Tyr Thr Thr Glu Glu Ser Leu Glu Ala Ala Lys Ala 
            820                 825                 830         

Lys Ile Phe Glu Lys Phe Pro Gly Leu Gln Glu Cys Lys Asp Ser Thr 
        835                 840                 845             

Tyr His Tyr Glu Ile Asn Cys Leu Glu Arg Arg Pro Gly Thr Asp Val 
    850                 855                 860                 

Pro Val Thr Gly Gly Met Tyr Val Pro Arg Tyr Thr Gln Leu Asn Leu 
865                 870                 875                 880 

Asp Ala Asp Thr Ala Lys Ala Met Val Gln Ala Ala Asp Leu Gly Thr 
                885                 890                 895     

Asn Ile Gln Arg Leu Tyr Gln His Glu Leu Tyr Phe Arg Thr Lys Gly 
            900                 905                 910         

Ser Lys Gly Glu Arg Leu Asn Ser Val Asp Leu Glu Arg Leu Tyr Gln 
        915                 920                 925             

Asn Met Ser Val Trp Leu Trp Asn Asp Thr Lys Tyr Arg Tyr Glu Glu 
    930                 935                 940                 

Gly Lys Glu Asp Glu Leu Gly Phe Lys Thr Phe Thr Glu Phe Leu Asn 
945                 950                 955                 960 

Cys Tyr Ala Asn Asp Ala Tyr Ala Gly Gly Thr Lys Cys Ser Ala Asp 
                965                 970                 975     

Leu Lys Lys Ser Leu Val Asp Asn Asn Met Ile Tyr Gly Asp Gly Ser 
            980                 985                 990         

Ser Lys Ala Gly Met Met Asn Pro Ser Tyr Pro Leu Asn Tyr Met Glu 
        995                 1000                1005            

Lys Pro Leu Thr Arg Leu Met Leu Gly Arg Ser Trp Trp Asp Leu Asn 
    1010                1015                1020                

Ile Lys Val Asp Val Glu Lys Tyr Pro Gly Ser Val Ser Ala Lys Gly 
1025                1030                1035                1040

Glu Ser Val Thr Glu Asn Ile Ser Leu Tyr Ser Asn Pro Thr Lys Trp 
                1045                1050                1055    

Phe Ala Gly Asn Met Gln Ser Thr Gly Leu Trp Ala Pro Ala Gln Gln 
            1060                1065                1070        

Asp Val Thr Ile Lys Ser Ser Ala Ser Val Pro Val Thr Val Thr Val 
        1075                1080                1085            

Ala Leu Ala Asp Asp Leu Thr Gly Arg Glu Lys His Glu Val Ala Leu 
    1090                1095                1100                

Asn Arg Pro Pro Arg Val Thr Lys Thr Tyr Thr Leu Glu Ala Asn Gly 
1105                1110                1115                1120

Glu Val Thr Phe Lys Val Pro Tyr Gly Gly Leu Ile Tyr Ile Lys Gly 
                1125                1130                1135    

Asp Ser Lys Asp Asp Val Ser Ala Asn Phe Thr Phe Thr Gly Val Val 
            1140                1145                1150        

Lys Ala Pro Phe Tyr Lys Asp Gly Glu Trp Lys Asn Asp Leu Asp Ser 
        1155                1160                1165            

Pro Ala Pro Leu Gly Glu Leu Glu Ser Ala Ser Phe Val Tyr Thr Thr 
    1170                1175                1180                

Pro Lys Lys Asn Leu Glu Ala Ser Asn Phe Thr Gly Gly Val Ala Glu 
1185                1190                1195                1200

Phe Ala Lys Asp Leu Asp Thr Phe Ala Ser Ser Met Asn Asp Phe Tyr 
                1205                1210                1215    

Gly Arg Asn Asp Glu Asp Gly Lys His Arg Met Phe Thr Tyr Lys Asn 
            1220                1225                1230        

Leu Thr Gly His Lys His Arg Phe Thr Asn Asp Val Gln Ile Ser Ile 
        1235                1240                1245            

Gly Asp Ala His Ser Gly Tyr Pro Val Met Asn Ser Ser Phe Ser Thr 
    1250                1255                1260                

Asn Ser Thr Thr Leu Pro Thr Thr Pro Leu Asn Asp Trp Leu Ile Trp 
1265                1270                1275                1280

His Glu Val Gly His Asn Ala Ala Glu Thr Pro Leu Asn Val Pro Gly 
                1285                1290                1295    

Ala Thr Glu Val Ala Asn Asn Val Leu Ala Leu Tyr Met Gln Asp Arg 
            1300                1305                1310        

Tyr Leu Gly Lys Met Asn Arg Val Ala Asp Asp Ile Thr Val Ala Pro 
        1315                1320                1325            

Glu Tyr Leu Asp Glu Ser Asn Gly Gln Ala Trp Ala Arg Gly Gly Ala 
    1330                1335                1340                

Gly Asp Arg Leu Leu Met Tyr Ala Gln Leu Lys Glu Trp Ala Glu Glu 
1345                1350                1355                1360

Asn Phe Asp Ile Lys Gln Trp Tyr Pro Asp Gly Glu Leu Pro Lys Phe 
                1365                1370                1375    

Tyr Ser Asp Arg Lys Gly Met Lys Gly Trp Asn Leu Phe Gln Leu Met 
            1380                1385                1390        

His Arg Lys Ala Arg Gly Ala Asp Val Gly Asn Ser Thr Phe Gly Gly 
        1395                1400                1405            

Lys Asn Tyr Cys Ala Glu Ser Asn Gly Asn Ala Ala Asp Thr Leu Met 
    1410                1415                1420                

Leu Cys Ala Ser Trp Val Ala Gln Ala Asp Leu Ser Glu Phe Phe Lys 
1425                1430                1435                1440

Lys Trp Asn Pro Gly Ala Ser Ala Tyr Gln Leu Pro Gly Ala Thr Glu 
                1445                1450                1455    

Met Ser Phe Gln Gly Gly Val Ser Ser Ser Ala Tyr Ser Thr Leu Ala 
            1460                1465                1470        

Ser Leu Lys Leu Pro Lys Pro Glu Lys Gly Pro Glu Thr Ile Asn Lys 
        1475                1480                1485            

Val Thr Glu His Lys Met Ser Ala Glu 
    1490                1495        

<210>   23
<211>   2184
<212>   DNA
<213>   Escherichia coli

<400>   23
gatacgccgt ctgtagattc tggatcaggg actttgccgg aagtgaaacc cgatccaaca  60
ccaaccccgg agccgacacc tgagccgacg ccggacccag aacctacgcc ggatccaaca  120
cctgatcctg agccgacacc agaaccggag ccagaacctg ttcctacgaa aacgggttat  180
ctgaccctgg gcggaagcca gcgggtaact ggtgctacct gtaatggtga atccagcgat  240
ggctttacct ttacgccagg caataccgtg agttgtgtgg tgggcagtac gaccattgca  300
acattcaaca cccagtcaga agctgcgcgt agcctgcgtg cggttgacaa agtgtcgttt  360
agcctggagg acgcgcagga gctggcgaat tctgaaaata agaaaaccaa cgccatctct  420
ctggtgacgt ccagcgacag ttgccccgca gatgcagaac agctttgtct tactttctcg  480
tcagtggttg atcgcgcgcg atttgaaaaa ctgtataagc aaattgatct ggcaacagac  540
aatttcagca agctggtcaa tgaagaggtg gaaaacaatg ctgcgactga taaagcgccg  600
tccacccata cctcaacggt agtgccagtc acgacagagg gaacaaaacc ggatctgaac  660
gcgtccttcg tgtcggctaa cgcggaacag ttttatcagt atcaacccac tgaaatcatt  720
ctttccgaag gccaactggt ggatagcctg gggaacggtg ttgctggcgt tgactactac  780
accaattcag gccgtggcgt aactgacgaa aacggtaaat tttcctttag ctggggcgaa  840
accatctcct ttggtatcga tacctttgaa ctgggctcag tacgtggcaa taagtcgacc  900
attgcgctga ctgaattggg tgatgaagtt cgcggggcaa atatcgatca gctcattcat  960
cgttattcga cgactggtca aaataatact cgtgttgttc cggacgatgt acgcaaggtc  1020
tttgccgaat atcccaacgt gatcaacgag ataatcaatc tttcgttatc caacggtgcg  1080
acgctggatg aaggcgatca aaacgttgtg ctgcctaacg aatttatcga gcagtttaag  1140
acgggtcagg ccaaagagat cgataccgcg atttgtgcga aaaccgacgg ttgtaacgag  1200
gctcgctggt tctcgctgac aacgcgcaat gttaatgacg gccagattca gggcgttatt  1260
aacaagctgt ggggcgtgga tacgaactat cagtctgtca gcaagttcca cgtcttccat  1320
gactctacca acttctatgg cagcaccggt aacgcgcgcg gtcaggcggt ggtaaatatc  1380
tccaactcgg cattcccgat tctgatggcg cgtaatgata aaaactactg gctggcgttt  1440
ggcgaaaaac gcgcctggga taaaaatgag ctggcgtaca ttacggaagc gccttccatt  1500
gtgcagccag agaacgttac gcgcgatact gcgactttca acctgccgtt tatttcgctg  1560
gggcaagtcg gtgaaggcaa actgatggtt atcggtaacc cgcactacaa cagcatcctg  1620
cgttgcccga acggttacag ttggggcggt ggtgttaata gtaaaggtga gtgtacgctc  1680
agcggtgatt ctgatgacat gaagcacttt atgcagaacg tactgcgcta cttgtcaaat  1740
gacatctggc agccaaatac caagagcatc atgactgtcg gcaccaacct ggagaacgtt  1800
tatttcaaaa aagcgggcca ggtattggga aatagtgcac catttgcttt ccatgaggat  1860
ttcactggta tcacggttaa acagttgacc agctatggcg atctgaatcc ggaagagatt  1920
ccgttgctga tcctcaacgg ctttgaatat gtgactcagt ggtctggcga tccctatgct  1980
gtgcctctgc gtgcagatac cagcaaaccg aagctgactc agcaggatgt gaccgatctg  2040
atcgcttatc tgaacaaagg tggctcggtg ctgatcatgg aaaacgtgat gagcaatctt  2100
aaggaagaga gcgcgtccag ttttgtgcgt ctgctggatg ccgcgggtct gtcaatggct  2160
ctgaacaaat cggtggtgaa caac                                         2184

<210>   24
<211>   728
<212>   PRT
<213>   Escherichia coli

<400>   24
Asp Thr Pro Ser Val Asp Ser Gly Ser Gly Thr Leu Pro Glu Val Lys 
1               5                   10                  15      

Pro Asp Pro Thr Pro Thr Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp 
            20                  25                  30          

Pro Glu Pro Thr Pro Asp Pro Thr Pro Asp Pro Glu Pro Thr Pro Glu 
        35                  40                  45              

Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu Gly 
    50                  55                  60                  

Gly Ser Gln Arg Val Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser Asp 
65                  70                  75                  80  

Gly Phe Thr Phe Thr Pro Gly Asn Thr Val Ser Cys Val Val Gly Ser 
                85                  90                  95      

Thr Thr Ile Ala Thr Phe Asn Thr Gln Ser Glu Ala Ala Arg Ser Leu 
            100                 105                 110         

Arg Ala Val Asp Lys Val Ser Phe Ser Leu Glu Asp Ala Gln Glu Leu 
        115                 120                 125             

Ala Asn Ser Glu Asn Lys Lys Thr Asn Ala Ile Ser Leu Val Thr Ser 
    130                 135                 140                 

Ser Asp Ser Cys Pro Ala Asp Ala Glu Gln Leu Cys Leu Thr Phe Ser 
145                 150                 155                 160 

Ser Val Val Asp Arg Ala Arg Phe Glu Lys Leu Tyr Lys Gln Ile Asp 
                165                 170                 175     

Leu Ala Thr Asp Asn Phe Ser Lys Leu Val Asn Glu Glu Val Glu Asn 
            180                 185                 190         

Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Thr Val Val 
        195                 200                 205             

Pro Val Thr Thr Glu Gly Thr Lys Pro Asp Leu Asn Ala Ser Phe Val 
    210                 215                 220                 

Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu Ile Ile 
225                 230                 235                 240 

Leu Ser Glu Gly Gln Leu Val Asp Ser Leu Gly Asn Gly Val Ala Gly 
                245                 250                 255     

Val Asp Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Asp Glu Asn Gly 
            260                 265                 270         

Lys Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile Asp Thr 
        275                 280                 285             

Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala Leu Thr 
    290                 295                 300                 

Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu Ile His 
305                 310                 315                 320 

Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val Pro Asp Asp 
                325                 330                 335     

Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu Ile Ile 
            340                 345                 350         

Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Asp Glu Gly Asp Gln Asn 
        355                 360                 365             

Val Val Leu Pro Asn Glu Phe Ile Glu Gln Phe Lys Thr Gly Gln Ala 
    370                 375                 380                 

Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly Cys Asn Glu 
385                 390                 395                 400 

Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly Gln Ile 
                405                 410                 415     

Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn Tyr Gln Ser 
            420                 425                 430         

Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr Gly Ser 
        435                 440                 445             

Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn Ser Ala 
    450                 455                 460                 

Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu Ala Phe 
465                 470                 475                 480 

Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile Thr Glu 
                485                 490                 495     

Ala Pro Ser Ile Val Gln Pro Glu Asn Val Thr Arg Asp Thr Ala Thr 
            500                 505                 510         

Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Glu Gly Lys Leu 
        515                 520                 525             

Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys Pro Asn 
    530                 535                 540                 

Gly Tyr Ser Trp Gly Gly Gly Val Asn Ser Lys Gly Glu Cys Thr Leu 
545                 550                 555                 560 

Ser Gly Asp Ser Asp Asp Met Lys His Phe Met Gln Asn Val Leu Arg 
                565                 570                 575     

Tyr Leu Ser Asn Asp Ile Trp Gln Pro Asn Thr Lys Ser Ile Met Thr 
            580                 585                 590         

Val Gly Thr Asn Leu Glu Asn Val Tyr Phe Lys Lys Ala Gly Gln Val 
        595                 600                 605             

Leu Gly Asn Ser Ala Pro Phe Ala Phe His Glu Asp Phe Thr Gly Ile 
    610                 615                 620                 

Thr Val Lys Gln Leu Thr Ser Tyr Gly Asp Leu Asn Pro Glu Glu Ile 
625                 630                 635                 640 

Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Trp Ser Gly 
                645                 650                 655     

Asp Pro Tyr Ala Val Pro Leu Arg Ala Asp Thr Ser Lys Pro Lys Leu 
            660                 665                 670         

Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn Lys Gly Gly 
        675                 680                 685             

Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu Glu Ser 
    690                 695                 700                 

Ala Ser Ser Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser Met Ala 
705                 710                 715                 720 

Leu Asn Lys Ser Val Val Asn Asn 
                725             

<210>   25
<211>   3810
<212>   DNA
<213>   Escherichia coli

<400>   25
gatacgccgt ctgtagattc tggatcaggg actttgccgg aagtgaaacc cgatccaaca  60
ccaaccccgg agccgacacc tgagccgacg ccggacccag aacctacgcc ggatccaaca  120
cctgatcctg agccgacacc agaaccggag ccagaacctg ttcctacgaa aacgggttat  180
ctgaccctgg gcggaagcca gcgggtaact ggtgctacct gtaatggtga atccagcgat  240
ggctttacct ttacgccagg caataccgtg agttgtgtgg tgggcagtac gaccattgca  300
acattcaaca cccagtcaga agctgcgcgt agcctgcgtg cggttgacaa agtgtcgttt  360
agcctggagg acgcgcagga gctggcgaat tctgaaaata agaaaaccaa cgccatctct  420
ctggtgacgt ccagcgacag ttgccccgca gatgcagaac agctttgtct tactttctcg  480
tcagtggttg atcgcgcgcg atttgaaaaa ctgtataagc aaattgatct ggcaacagac  540
aatttcagca agctggtcaa tgaagaggtg gaaaacaatg ctgcgactga taaagcgccg  600
tccacccata cctcaacggt agtgccagtc acgacagagg gaacaaaacc ggatctgaac  660
gcgtccttcg tgtcggctaa cgcggaacag ttttatcagt atcaacccac tgaaatcatt  720
ctttccgaag gccaactggt ggatagcctg gggaacggtg ttgctggcgt tgactactac  780
accaattcag gccgtggcgt aactgacgaa aacggtaaat tttcctttag ctggggcgaa  840
accatctcct ttggtatcga tacctttgaa ctgggctcag tacgtggcaa taagtcgacc  900
attgcgctga ctgaattggg tgatgaagtt cgcggggcaa atatcgatca gctcattcat  960
cgttattcga cgactggtca aaataatact cgtgttgttc cggacgatgt acgcaaggtc  1020
tttgccgaat atcccaacgt gatcaacgag ataatcaatc tttcgttatc caacggtgcg  1080
acgctggatg aaggcgatca aaacgttgtg ctgcctaacg aatttatcga gcagtttaag  1140
acgggtcagg ccaaagagat cgataccgcg atttgtgcga aaaccgacgg ttgtaacgag  1200
gctcgctggt tctcgctgac aacgcgcaat gttaatgacg gccagattca gggcgttatt  1260
aacaagctgt ggggcgtgga tacgaactat cagtctgtca gcaagttcca cgtcttccat  1320
gactctacca acttctatgg cagcaccggt aacgcgcgcg gtcaggcggt ggtaaatatc  1380
tccaactcgg cattcccgat tctgatggcg cgtaatgata aaaactactg gctggcgttt  1440
ggcgaaaaac gcgcctggga taaaaatgag ctggcgtaca ttacggaagc gccttccatt  1500
gtgcagccag agaacgttac gcgcgatact gcgactttca acctgccgtt tatttcgctg  1560
gggcaagtcg gtgaaggcaa actgatggtt atcggtaacc cgcactacaa cagcatcctg  1620
cgttgcccga acggttacag ttggggcggt ggtgttaata gtaaaggtga gtgtacgctc  1680
agcggtgatt ctgatgacat gaagcacttt atgcagaacg tactgcgcta cttgtcaaat  1740
gacatctggc agccaaatac caagagcatc atgactgtcg gcaccaacct ggagaacgtt  1800
tatttcaaaa aagcgggcca ggtattggga aatagtgcac catttgcttt ccatgaggat  1860
ttcactggta tcacggttaa acagttgacc agctatggcg atctgaatcc ggaagagatt  1920
ccgttgctga tcctcaacgg ctttgaatat gtgactcagt ggtctggcga tccctatgct  1980
gtgcctctgc gtgcagatac cagcaaaccg aagctgactc agcaggatgt gaccgatctg  2040
atcgcttatc tgaacaaagg tggctcggtg ctgatcatgg aaaacgtgat gagcaatctt  2100
aaggaagaga gcgcgtccag ttttgtgcgt ctgctggatg ccgcgggtct gtcaatggct  2160
ctgaacaaat cggtggtgaa caacgatccg caagggtatc cggatcgcgt tcgtcagcgt  2220
cgcgcgactg gcatttgggt ttatgaacgt tatcctgctg cagacggcgc gcaaccgccg  2280
tacaccatcg acccaaatac aggggaagtg acctggaaat accagcaaga caacaagcct  2340
gatgacaagc cgaaactgga agttgcgagc tggcaggagg aagttgaggg caaacaggta  2400
acgcgttatg cctttattga tgaagcggaa tacacaacag aagaatctct ggaagcggca  2460
aaggcaaaaa tctttgagaa gtttcctggg ttacaggagt gtaaggactc gacttaccat  2520
tacgagatta actgtttgga gcgccgccca ggcacggatg ttccggtaac aggtggcatg  2580
tatgttccgc gctatacgca actgaatctt gacgccgaca ccgcgaaagc gatggtgcag  2640
gcggcggatt taggcaccaa cattcagcgc ctgtatcagc atgagcttta tttccgtacc  2700
aaaggcagta aaggtgagcg tctgaacagt gttgatctgg aacgtctgta ccagaacatg  2760
tcggtctggc tgtggaacga tacgaaatat cgttacgaag agggcaagga agatgagctg  2820
ggctttaaaa cgttcaccga gttcctgaac tgctacgcca atgatgccta tgcaggcggc  2880
accaagtgct ccgcagatct gaaaaaatcg ctggtcgata acaacatgat ctacggtgac  2940
ggtagcagca aagcgggcat gatgaaccca agctatccgc tcaactatat ggaaaaaccg  3000
ctgacgcgtc tgatgctggg ccgttcctgg tgggatctga acattaaggt tgatgtggag  3060
aagtacccag gatccgtatc ggcaaagggt gagagcgtta cggaaaacat cagcctgtac  3120
tcgaatccga ccaaatggtt tgcgggtaac atgcagtcaa ccggcctgtg ggcaccggcc  3180
cagcaggacg tcaccattaa gtcttcggcg tcagtcccag tgactgttac cgtggcgctg  3240
gctgacgacc tgactggacg tgagaagcat gaagttgcgc tgaaccgtcc gccaagagtg  3300
actaaaacgt atactctgga ggctaacggt gaagtgacct tcaaggtgcc ttatggtggt  3360
ctgatttata tcaagggcga cagtaaggat gatgtttctg ctaacttcac ctttaccggt  3420
gtagtaaaag cgccgttcta taaagacggc gaatggaaaa acgatctgga ctcaccggcg  3480
ccgctgggcg agctggagtc tgcgtcgttc gtctatacca cgccgaagaa gaaccttgag  3540
gccagcaatt tcactggtgg tgtagcagaa ttcgctaaag atctggatac ctttgccagc  3600
tcgatgaatg acttctacgg tcgtaatgat gaagacggta agcaccggat gtttacctat  3660
aaaaacttga cggggcacaa gcatcgtttc accaacgatg tgcagatctc catcggtgat  3720
gcgcactcgg gttatccggt aatgaacagc agcttctcga cgaacagcac cacgctgccg  3780
acgacgccgc tgaacgactg gctgatttgg                                   3810

<210>   26
<211>   1270
<212>   PRT
<213>   Escherichia coli

<400>   26
Asp Thr Pro Ser Val Asp Ser Gly Ser Gly Thr Leu Pro Glu Val Lys 
1               5                   10                  15      

Pro Asp Pro Thr Pro Thr Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp 
            20                  25                  30          

Pro Glu Pro Thr Pro Asp Pro Thr Pro Asp Pro Glu Pro Thr Pro Glu 
        35                  40                  45              

Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu Gly 
    50                  55                  60                  

Gly Ser Gln Arg Val Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser Asp 
65                  70                  75                  80  

Gly Phe Thr Phe Thr Pro Gly Asn Thr Val Ser Cys Val Val Gly Ser 
                85                  90                  95      

Thr Thr Ile Ala Thr Phe Asn Thr Gln Ser Glu Ala Ala Arg Ser Leu 
            100                 105                 110         

Arg Ala Val Asp Lys Val Ser Phe Ser Leu Glu Asp Ala Gln Glu Leu 
        115                 120                 125             

Ala Asn Ser Glu Asn Lys Lys Thr Asn Ala Ile Ser Leu Val Thr Ser 
    130                 135                 140                 

Ser Asp Ser Cys Pro Ala Asp Ala Glu Gln Leu Cys Leu Thr Phe Ser 
145                 150                 155                 160 

Ser Val Val Asp Arg Ala Arg Phe Glu Lys Leu Tyr Lys Gln Ile Asp 
                165                 170                 175     

Leu Ala Thr Asp Asn Phe Ser Lys Leu Val Asn Glu Glu Val Glu Asn 
            180                 185                 190         

Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Thr Val Val 
        195                 200                 205             

Pro Val Thr Thr Glu Gly Thr Lys Pro Asp Leu Asn Ala Ser Phe Val 
    210                 215                 220                 

Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu Ile Ile 
225                 230                 235                 240 

Leu Ser Glu Gly Gln Leu Val Asp Ser Leu Gly Asn Gly Val Ala Gly 
                245                 250                 255     

Val Asp Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Asp Glu Asn Gly 
            260                 265                 270         

Lys Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile Asp Thr 
        275                 280                 285             

Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala Leu Thr 
    290                 295                 300                 

Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu Ile His 
305                 310                 315                 320 

Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val Pro Asp Asp 
                325                 330                 335     

Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu Ile Ile 
            340                 345                 350         

Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Asp Glu Gly Asp Gln Asn 
        355                 360                 365             

Val Val Leu Pro Asn Glu Phe Ile Glu Gln Phe Lys Thr Gly Gln Ala 
    370                 375                 380                 

Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly Cys Asn Glu 
385                 390                 395                 400 

Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly Gln Ile 
                405                 410                 415     

Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn Tyr Gln Ser 
            420                 425                 430         

Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr Gly Ser 
        435                 440                 445             

Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn Ser Ala 
    450                 455                 460                 

Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu Ala Phe 
465                 470                 475                 480 

Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile Thr Glu 
                485                 490                 495     

Ala Pro Ser Ile Val Gln Pro Glu Asn Val Thr Arg Asp Thr Ala Thr 
            500                 505                 510         

Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Glu Gly Lys Leu 
        515                 520                 525             

Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys Pro Asn 
    530                 535                 540                 

Gly Tyr Ser Trp Gly Gly Gly Val Asn Ser Lys Gly Glu Cys Thr Leu 
545                 550                 555                 560 

Ser Gly Asp Ser Asp Asp Met Lys His Phe Met Gln Asn Val Leu Arg 
                565                 570                 575     

Tyr Leu Ser Asn Asp Ile Trp Gln Pro Asn Thr Lys Ser Ile Met Thr 
            580                 585                 590         

Val Gly Thr Asn Leu Glu Asn Val Tyr Phe Lys Lys Ala Gly Gln Val 
        595                 600                 605             

Leu Gly Asn Ser Ala Pro Phe Ala Phe His Glu Asp Phe Thr Gly Ile 
    610                 615                 620                 

Thr Val Lys Gln Leu Thr Ser Tyr Gly Asp Leu Asn Pro Glu Glu Ile 
625                 630                 635                 640 

Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Trp Ser Gly 
                645                 650                 655     

Asp Pro Tyr Ala Val Pro Leu Arg Ala Asp Thr Ser Lys Pro Lys Leu 
            660                 665                 670         

Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn Lys Gly Gly 
        675                 680                 685             

Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu Glu Ser 
    690                 695                 700                 

Ala Ser Ser Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser Met Ala 
705                 710                 715                 720 

Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro Asp Arg 
                725                 730                 735     

Val Arg Gln Arg Arg Ala Thr Gly Ile Trp Val Tyr Glu Arg Tyr Pro 
            740                 745                 750         

Ala Ala Asp Gly Ala Gln Pro Pro Tyr Thr Ile Asp Pro Asn Thr Gly 
        755                 760                 765             

Glu Val Thr Trp Lys Tyr Gln Gln Asp Asn Lys Pro Asp Asp Lys Pro 
    770                 775                 780                 

Lys Leu Glu Val Ala Ser Trp Gln Glu Glu Val Glu Gly Lys Gln Val 
785                 790                 795                 800 

Thr Arg Tyr Ala Phe Ile Asp Glu Ala Glu Tyr Thr Thr Glu Glu Ser 
                805                 810                 815     

Leu Glu Ala Ala Lys Ala Lys Ile Phe Glu Lys Phe Pro Gly Leu Gln 
            820                 825                 830         

Glu Cys Lys Asp Ser Thr Tyr His Tyr Glu Ile Asn Cys Leu Glu Arg 
        835                 840                 845             

Arg Pro Gly Thr Asp Val Pro Val Thr Gly Gly Met Tyr Val Pro Arg 
    850                 855                 860                 

Tyr Thr Gln Leu Asn Leu Asp Ala Asp Thr Ala Lys Ala Met Val Gln 
865                 870                 875                 880 

Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu Leu 
                885                 890                 895     

Tyr Phe Arg Thr Lys Gly Ser Lys Gly Glu Arg Leu Asn Ser Val Asp 
            900                 905                 910         

Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Asp Thr 
        915                 920                 925             

Lys Tyr Arg Tyr Glu Glu Gly Lys Glu Asp Glu Leu Gly Phe Lys Thr 
    930                 935                 940                 

Phe Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asp Ala Tyr Ala Gly Gly 
945                 950                 955                 960 

Thr Lys Cys Ser Ala Asp Leu Lys Lys Ser Leu Val Asp Asn Asn Met 
                965                 970                 975     

Ile Tyr Gly Asp Gly Ser Ser Lys Ala Gly Met Met Asn Pro Ser Tyr 
            980                 985                 990         

Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly Arg 
        995                 1000                1005            

Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro Gly 
    1010                1015                1020                

Ser Val Ser Ala Lys Gly Glu Ser Val Thr Glu Asn Ile Ser Leu Tyr 
1025                1030                1035                1040

Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly Leu 
                1045                1050                1055    

Trp Ala Pro Ala Gln Gln Asp Val Thr Ile Lys Ser Ser Ala Ser Val 
            1060                1065                1070        

Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg Glu 
        1075                1080                1085            

Lys His Glu Val Ala Leu Asn Arg Pro Pro Arg Val Thr Lys Thr Tyr 
    1090                1095                1100                

Thr Leu Glu Ala Asn Gly Glu Val Thr Phe Lys Val Pro Tyr Gly Gly 
1105                1110                1115                1120

Leu Ile Tyr Ile Lys Gly Asp Ser Lys Asp Asp Val Ser Ala Asn Phe 
                1125                1130                1135    

Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Glu Trp 
            1140                1145                1150        

Lys Asn Asp Leu Asp Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser Ala 
        1155                1160                1165            

Ser Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Glu Ala Ser Asn Phe 
    1170                1175                1180                

Thr Gly Gly Val Ala Glu Phe Ala Lys Asp Leu Asp Thr Phe Ala Ser 
1185                1190                1195                1200

Ser Met Asn Asp Phe Tyr Gly Arg Asn Asp Glu Asp Gly Lys His Arg 
                1205                1210                1215    

Met Phe Thr Tyr Lys Asn Leu Thr Gly His Lys His Arg Phe Thr Asn 
            1220                1225                1230        

Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val Met 
        1235                1240                1245            

Asn Ser Ser Phe Ser Thr Asn Ser Thr Thr Leu Pro Thr Thr Pro Leu 
    1250                1255                1260                

Asn Asp Trp Leu Ile Trp 
1265                1270

<210>   27
<211>   4563
<212>   DNA
<213>   Escherichia coli

<400>   27
atgaataaga aatttaaata taagaaatcg cttttagcgg ctattttaag cgcaaccctg  60
ttagccggtt gtgatggtgg tggttcagga tcgtcctccg atacgccgtc tgtagattct  120
ggatcaggga ctttgccgga agtgaaaccc gatccaacac caaccccgga gccgacacct  180
gagccgacgc cggacccaga acctacgccg gatccaacac ctgatcctga gccgacacca  240
gaaccggagc cagaacctgt tcctacgaaa acgggttatc tgaccctggg cggaagccag  300
cgggtaactg gtgctacctg taatggtgaa tccagcgatg gctttacctt tacgccaggc  360
aataccgtga gttgtgtggt gggcagtacg accattgcaa cattcaacac ccagtcagaa  420
gctgcgcgta gcctgcgtgc ggttgacaaa gtgtcgttta gcctggagga cgcgcaggag  480
ctggcgaatt ctgaaaataa gaaaaccaac gccatctctc tggtgacgtc cagcgacagt  540
tgccccgcag atgcagaaca gctttgtctt actttctcgt cagtggttga tcgcgcgcga  600
tttgaaaaac tgtataagca aattgatctg gcaacagaca atttcagcaa gctggtcaat  660
gaagaggtgg aaaacaatgc tgcgactgat aaagcgccgt ccacccatac ctcaacggta  720
gtgccagtca cgacagaggg aacaaaaccg gatctgaacg cgtccttcgt gtcggctaac  780
gcggaacagt tttatcagta tcaacccact gaaatcattc tttccgaagg ccaactggtg  840
gatagcctgg ggaacggtgt tgctggcgtt gactactaca ccaattcagg ccgtggcgta  900
actgacgaaa acggtaaatt ttcctttagc tggggcgaaa ccatctcctt tggtatcgat  960
acctttgaac tgggctcagt acgtggcaat aagtcgacca ttgcgctgac tgaattgggt  1020
gatgaagttc gcggggcaaa tatcgatcag ctcattcatc gttattcgac gactggtcaa  1080
aataatactc gtgttgttcc ggacgatgta cgcaaggtct ttgccgaata tcccaacgtg  1140
atcaacgaga taatcaatct ttcgttatcc aacggtgcga cgctggatga aggcgatcaa  1200
aacgttgtgc tgcctaacga atttatcgag cagtttaaga cgggtcaggc caaagagatc  1260
gataccgcga tttgtgcgaa aaccgacggt tgtaacgagg ctcgctggtt ctcgctgaca  1320
acgcgcaatg ttaatgacgg ccagattcag ggcgttatta acaagctgtg gggcgtggat  1380
acgaactatc agtctgtcag caagttccac gtcttccatg actctaccaa cttctatggc  1440
agcaccggta acgcgcgcgg tcaggcggtg gtaaatatct ccaactcggc attcccgatt  1500
ctgatggcgc gtaatgataa aaactactgg ctggcgtttg gcgaaaaacg cgcctgggat  1560
aaaaatgagc tggcgtacat tacggaagcg ccttccattg tgcagccaga gaacgttacg  1620
cgcgatactg cgactttcaa cctgccgttt atttcgctgg ggcaagtcgg tgaaggcaaa  1680
ctgatggtta tcggtaaccc gcactacaac agcatcctgc gttgcccgaa cggttacagt  1740
tggggcggtg gtgttaatag taaaggtgag tgtacgctca gcggtgattc tgatgacatg  1800
aagcacttta tgcagaacgt actgcgctac ttgtcaaatg acatctggca gccaaatacc  1860
aagagcatca tgactgtcgg caccaacctg gagaacgttt atttcaaaaa agcgggccag  1920
gtattgggaa atagtgcacc atttgctttc catgaggatt tcactggtat cacggttaaa  1980
cagttgacca gctatggcga tctgaatccg gaagagattc cgttgctgat cctcaacggc  2040
tttgaatatg tgactcagtg gtctggcgat ccctatgctg tgcctctgcg tgcagatacc  2100
agcaaaccga agctgactca gcaggatgtg accgatctga tcgcttatct gaacaaaggt  2160
ggctcggtgc tgatcatgga aaacgtgatg agcaatctta aggaagagag cgcgtccagt  2220
tttgtgcgtc tgctggatgc cgcgggtctg tcaatggctc tgaacaaatc ggtggtgaac  2280
aacgatccgc aagggtatcc ggatcgcgtt cgtcagcgtc gcgcgactgg catttgggtt  2340
tatgaacgtt atcctgctgc agacggcgcg caaccgccgt acaccatcga cccaaataca  2400
ggggaagtga cctggaaata ccagcaagac aacaagcctg atgacaagcc gaaactggaa  2460
gttgcgagct ggcaggagga agttgagggc aaacaggtaa cgcgttatgc ctttattgat  2520
gaagcggaat acacaacaga agaatctctg gaagcggcaa aggcaaaaat ctttgagaag  2580
tttcctgggt tacaggagtg taaggactcg acttaccatt acgagattaa ctgtttggag  2640
cgccgcccag gcacggatgt tccggtaaca ggtggcatgt atgttccgcg ctatacgcaa  2700
ctgaatcttg acgccgacac cgcgaaagcg atggtgcagg cggcggattt aggcaccaac  2760
attcagcgcc tgtatcagca tgagctttat ttccgtacca aaggcagtaa aggtgagcgt  2820
ctgaacagtg ttgatctgga acgtctgtac cagaacatgt cggtctggct gtggaacgat  2880
acgaaatatc gttacgaaga gggcaaggaa gatgagctgg gctttaaaac gttcaccgag  2940
ttcctgaact gctacgccaa tgatgcctat gcaggcggca ccaagtgctc cgcagatctg  3000
aaaaaatcgc tggtcgataa caacatgatc tacggtgacg gtagcagcaa agcgggcatg  3060
atgaacccaa gctatccgct caactatatg gaaaaaccgc tgacgcgtct gatgctgggc  3120
cgttcctggt gggatctgaa cattaaggtt gatgtggaga agtacccagg atccgtatcg  3180
gcaaagggtg agagcgttac ggaaaacatc agcctgtact cgaatccgac caaatggttt  3240
gcgggtaaca tgcagtcaac cggcctgtgg gcaccggccc agcaggacgt caccattaag  3300
tcttcggcgt cagtcccagt gactgttacc gtggcgctgg ctgacgacct gactggacgt  3360
gagaagcatg aagttgcgct gaaccgtccg ccaagagtga ctaaaacgta tactctggag  3420
gctaacggtg aagtgacctt caaggtgcct tatggtggtc tgatttatat caagggcgac  3480
agtaaggatg atgtttctgc taacttcacc tttaccggtg tagtaaaagc gccgttctat  3540
aaagacggcg aatggaaaaa cgatctggac tcaccggcgc cgctgggcga gctggagtct  3600
gcgtcgttcg tctataccac gccgaagaag aaccttgagg ccagcaattt cactggtggt  3660
gtagcagaat tcgctaaaga tctggatacc tttgccagct cgatgaatga cttctacggt  3720
cgtaatgatg aagacggtaa gcaccggatg tttacctata aaaacttgac ggggcacaag  3780
catcgtttca ccaacgatgt gcagatctcc atcggtgatg cgcactcggg ttatccggta  3840
atgaacagca gcttctcgac gaacagcacc acgctgccga cgacgccgct gaacgactgg  3900
ctgatttggc acgaagtcgg tcataacgct gcagaaacac cgctgaacgt accgggtgca  3960
actgaagtgg cgaacaacgt gctggcgctg tacatgcagg atcgctatct cggtaagatg  4020
aaccgtgtcg ctgacgacat taccgtcgcg ccggaatatc tggacgagag caacggtcag  4080
gcctgggcgc gcggcggtgc gggtgaccgt ctgctgatgt acgcacagtt gaaggagtgg  4140
gcagaggaaa actttgatat caaacagtgg tatccagatg gtgagctgcc taagttctac  4200
agcgatcgta aagggatgaa gggctggaac ctgttccagt tgatgcaccg taaagcgcgc  4260
ggcgatgatg ttggtaacag cacctttggt ggcaagaatt actgtgctga atccaatggt  4320
aacgctgccg acacgctgat gctgtgtgca tcctgggtcg ctcaggcgga tctttcggaa  4380
ttctttaaga aatggaatcc gggtgcaagt gcttaccagt tgccgggagc aacggagatg  4440
agtttccagg gcggtgtgag ctcttcggct tacagcacgc tggcgtcact caagctgccg  4500
aaaccggaaa aagggccgga aaccattaac aaggttaccg agcataagat gtctgccgag  4560
taa                                                                4563

<210>   28
<211>   1520
<212>   PRT
<213>   Escherichia coli

<400>   28
Met Asn Lys Lys Phe Lys Tyr Lys Lys Ser Leu Leu Ala Ala Ile Leu 
1               5                   10                  15      

Ser Ala Thr Leu Leu Ala Gly Cys Asp Gly Gly Gly Ser Gly Ser Ser 
            20                  25                  30          

Ser Asp Thr Pro Ser Val Asp Ser Gly Ser Gly Thr Leu Pro Glu Val 
        35                  40                  45              

Lys Pro Asp Pro Thr Pro Thr Pro Glu Pro Thr Pro Glu Pro Thr Pro 
    50                  55                  60                  

Asp Pro Glu Pro Thr Pro Asp Pro Thr Pro Asp Pro Glu Pro Thr Pro 
65                  70                  75                  80  

Glu Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu 
                85                  90                  95      

Gly Gly Ser Gln Arg Val Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser 
            100                 105                 110         

Asp Gly Phe Thr Phe Thr Pro Gly Asn Thr Val Ser Cys Val Val Gly 
        115                 120                 125             

Ser Thr Thr Ile Ala Thr Phe Asn Thr Gln Ser Glu Ala Ala Arg Ser 
    130                 135                 140                 

Leu Arg Ala Val Asp Lys Val Ser Phe Ser Leu Glu Asp Ala Gln Glu 
145                 150                 155                 160 

Leu Ala Asn Ser Glu Asn Lys Lys Thr Asn Ala Ile Ser Leu Val Thr 
                165                 170                 175     

Ser Ser Asp Ser Cys Pro Ala Asp Ala Glu Gln Leu Cys Leu Thr Phe 
            180                 185                 190         

Ser Ser Val Val Asp Arg Ala Arg Phe Glu Lys Leu Tyr Lys Gln Ile 
        195                 200                 205             

Asp Leu Ala Thr Asp Asn Phe Ser Lys Leu Val Asn Glu Glu Val Glu 
    210                 215                 220                 

Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Thr Val 
225                 230                 235                 240 

Val Pro Val Thr Thr Glu Gly Thr Lys Pro Asp Leu Asn Ala Ser Phe 
                245                 250                 255     

Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu Ile 
            260                 265                 270         

Ile Leu Ser Glu Gly Gln Leu Val Asp Ser Leu Gly Asn Gly Val Ala 
        275                 280                 285             

Gly Val Asp Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Asp Glu Asn 
    290                 295                 300                 

Gly Lys Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile Asp 
305                 310                 315                 320 

Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala Leu 
                325                 330                 335     

Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu Ile 
            340                 345                 350         

His Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val Pro Asp 
        355                 360                 365             

Asp Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu Ile 
    370                 375                 380                 

Ile Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Asp Glu Gly Asp Gln 
385                 390                 395                 400 

Asn Val Val Leu Pro Asn Glu Phe Ile Glu Gln Phe Lys Thr Gly Gln 
                405                 410                 415     

Ala Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly Cys Asn 
            420                 425                 430         

Glu Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly Gln 
        435                 440                 445             

Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn Tyr Gln 
    450                 455                 460                 

Ser Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr Gly 
465                 470                 475                 480 

Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn Ser 
                485                 490                 495     

Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu Ala 
            500                 505                 510         

Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile Thr 
        515                 520                 525             

Glu Ala Pro Ser Ile Val Gln Pro Glu Asn Val Thr Arg Asp Thr Ala 
    530                 535                 540                 

Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Glu Gly Lys 
545                 550                 555                 560 

Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys Pro 
                565                 570                 575     

Asn Gly Tyr Ser Trp Gly Gly Gly Val Asn Ser Lys Gly Glu Cys Thr 
            580                 585                 590         

Leu Ser Gly Asp Ser Asp Asp Met Lys His Phe Met Gln Asn Val Leu 
        595                 600                 605             

Arg Tyr Leu Ser Asn Asp Ile Trp Gln Pro Asn Thr Lys Ser Ile Met 
    610                 615                 620                 

Thr Val Gly Thr Asn Leu Glu Asn Val Tyr Phe Lys Lys Ala Gly Gln 
625                 630                 635                 640 

Val Leu Gly Asn Ser Ala Pro Phe Ala Phe His Glu Asp Phe Thr Gly 
                645                 650                 655     

Ile Thr Val Lys Gln Leu Thr Ser Tyr Gly Asp Leu Asn Pro Glu Glu 
            660                 665                 670         

Ile Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Trp Ser 
        675                 680                 685             

Gly Asp Pro Tyr Ala Val Pro Leu Arg Ala Asp Thr Ser Lys Pro Lys 
    690                 695                 700                 

Leu Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn Lys Gly 
705                 710                 715                 720 

Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu Glu 
                725                 730                 735     

Ser Ala Ser Ser Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser Met 
            740                 745                 750         

Ala Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro Asp 
        755                 760                 765             

Arg Val Arg Gln Arg Arg Ala Thr Gly Ile Trp Val Tyr Glu Arg Tyr 
    770                 775                 780                 

Pro Ala Ala Asp Gly Ala Gln Pro Pro Tyr Thr Ile Asp Pro Asn Thr 
785                 790                 795                 800 

Gly Glu Val Thr Trp Lys Tyr Gln Gln Asp Asn Lys Pro Asp Asp Lys 
                805                 810                 815     

Pro Lys Leu Glu Val Ala Ser Trp Gln Glu Glu Val Glu Gly Lys Gln 
            820                 825                 830         

Val Thr Arg Tyr Ala Phe Ile Asp Glu Ala Glu Tyr Thr Thr Glu Glu 
        835                 840                 845             

Ser Leu Glu Ala Ala Lys Ala Lys Ile Phe Glu Lys Phe Pro Gly Leu 
    850                 855                 860                 

Gln Glu Cys Lys Asp Ser Thr Tyr His Tyr Glu Ile Asn Cys Leu Glu 
865                 870                 875                 880 

Arg Arg Pro Gly Thr Asp Val Pro Val Thr Gly Gly Met Tyr Val Pro 
                885                 890                 895     

Arg Tyr Thr Gln Leu Asn Leu Asp Ala Asp Thr Ala Lys Ala Met Val 
            900                 905                 910         

Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu 
        915                 920                 925             

Leu Tyr Phe Arg Thr Lys Gly Ser Lys Gly Glu Arg Leu Asn Ser Val 
    930                 935                 940                 

Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Asp 
945                 950                 955                 960 

Thr Lys Tyr Arg Tyr Glu Glu Gly Lys Glu Asp Glu Leu Gly Phe Lys 
                965                 970                 975     

Thr Phe Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asp Ala Tyr Ala Gly 
            980                 985                 990         

Gly Thr Lys Cys Ser Ala Asp Leu Lys Lys Ser Leu Val Asp Asn Asn 
        995                 1000                1005            

Met Ile Tyr Gly Asp Gly Ser Ser Lys Ala Gly Met Met Asn Pro Ser 
    1010                1015                1020                

Tyr Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly 
1025                1030                1035                1040

Arg Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro 
                1045                1050                1055    

Gly Ser Val Ser Ala Lys Gly Glu Ser Val Thr Glu Asn Ile Ser Leu 
            1060                1065                1070        

Tyr Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly 
        1075                1080                1085            

Leu Trp Ala Pro Ala Gln Gln Asp Val Thr Ile Lys Ser Ser Ala Ser 
    1090                1095                1100                

Val Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg 
1105                1110                1115                1120

Glu Lys His Glu Val Ala Leu Asn Arg Pro Pro Arg Val Thr Lys Thr 
                1125                1130                1135    

Tyr Thr Leu Glu Ala Asn Gly Glu Val Thr Phe Lys Val Pro Tyr Gly 
            1140                1145                1150        

Gly Leu Ile Tyr Ile Lys Gly Asp Ser Lys Asp Asp Val Ser Ala Asn 
        1155                1160                1165            

Phe Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Glu 
    1170                1175                1180                

Trp Lys Asn Asp Leu Asp Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser 
1185                1190                1195                1200

Ala Ser Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Glu Ala Ser Asn 
                1205                1210                1215    

Phe Thr Gly Gly Val Ala Glu Phe Ala Lys Asp Leu Asp Thr Phe Ala 
            1220                1225                1230        

Ser Ser Met Asn Asp Phe Tyr Gly Arg Asn Asp Glu Asp Gly Lys His 
        1235                1240                1245            

Arg Met Phe Thr Tyr Lys Asn Leu Thr Gly His Lys His Arg Phe Thr 
    1250                1255                1260                

Asn Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val 
1265                1270                1275                1280

Met Asn Ser Ser Phe Ser Thr Asn Ser Thr Thr Leu Pro Thr Thr Pro 
                1285                1290                1295    

Leu Asn Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala Glu 
            1300                1305                1310        

Thr Pro Leu Asn Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu 
        1315                1320                1325            

Ala Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala 
    1330                1335                1340                

Asp Asp Ile Thr Val Ala Pro Glu Tyr Leu Asp Glu Ser Asn Gly Gln 
1345                1350                1355                1360

Ala Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln 
                1365                1370                1375    

Leu Lys Glu Trp Ala Glu Glu Asn Phe Asp Ile Lys Gln Trp Tyr Pro 
            1380                1385                1390        

Asp Gly Glu Leu Pro Lys Phe Tyr Ser Asp Arg Lys Gly Met Lys Gly 
        1395                1400                1405            

Trp Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Asp Val 
    1410                1415                1420                

Gly Asn Ser Thr Phe Gly Gly Lys Asn Tyr Cys Ala Glu Ser Asn Gly 
1425                1430                1435                1440

Asn Ala Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln Ala 
                1445                1450                1455    

Asp Leu Ser Glu Phe Phe Lys Lys Trp Asn Pro Gly Ala Ser Ala Tyr 
            1460                1465                1470        

Gln Leu Pro Gly Ala Thr Glu Met Ser Phe Gln Gly Gly Val Ser Ser 
        1475                1480                1485            

Ser Ala Tyr Ser Thr Leu Ala Ser Leu Lys Leu Pro Lys Pro Glu Lys 
    1490                1495                1500                

Gly Pro Glu Thr Ile Asn Lys Val Thr Glu His Lys Met Ser Ala Glu 
1505                1510                1515                1520

<210>   29
<211>   975
<212>   DNA
<213>   Escherichia coli

<400>   29
atgatcacct caccaccaaa acgcggaatg gcactggtcg tggtgctggt attgctggcg  60
gttatgatgc tggtgaccat cacgctttcc gggcggatgc agcaacaact tgggcgaacg  120
cgcagccagc aggagtacca gcaggcgctg tggtacagcg ccagtgcaga aagcctggcg  180
ctgagcgcgc tcagtctgag cctgaaaaat gaaaagcgtg tgcatctggc acaaccgtgg  240
gcttctggcc cgcgtttttt cccactgccg caggggcaaa ttgccgtcac tctgcgtgac  300
gcacaggcct gctttaacct gaatgccctc gctcagccga cgacggcgtc gcgtccgctc  360
gcggtacaac aactgattgc cctgatctcg cgcctcgatg tgcctgctta tcgggccgaa  420
ctgatagccg aaagcctgtg ggagtttatt gacgaagacc gcagcgtgca gacgcgtctg  480
ggtcgtgaag acagcgagta tctcgcccgc tcggtgccgt tctacgccgc taatcaaccg  540
ctggctgata tcagcgagat gcgcgtggtg cagggaatgg acgccgggct ttatcaaaaa  600
ctgaaaccgt tggtctgtgc gctgccgatg gcccgccagc aaatcaacat caatacatta  660
gatgtcacgc aaagtgtgat tcttgaggcg ctgtttgacc cgtggttaag ccctgttcag  720
gcgcgggcat tattacaaca acgtccggcg aagggctggg aagatgtcga tcagtttctt  780
gctcagccgc tacttgcaga cgtcgatgag cgtactaaaa aacagctaaa aaccatcctg  840
agcgtggaca gcaattactt ctggctgcgt tcagatatca ccgtgaatga gattgaactg  900
acgatgaatt cgttaattgt ccgcatgggc ccacaacact tttctgttct ctggcatcag  960
acaggagaaa gtgag                                                   975

<210>   30
<211>   325
<212>   PRT
<213>   Escherichia coli

<400>   30
Met Ile Thr Ser Pro Pro Lys Arg Gly Met Ala Leu Val Val Val Leu 
1               5                   10                  15      

Val Leu Leu Ala Val Met Met Leu Val Thr Ile Thr Leu Ser Gly Arg 
            20                  25                  30          

Met Gln Gln Gln Leu Gly Arg Thr Arg Ser Gln Gln Glu Tyr Gln Gln 
        35                  40                  45              

Ala Leu Trp Tyr Ser Ala Ser Ala Glu Ser Leu Ala Leu Ser Ala Leu 
    50                  55                  60                  

Ser Leu Ser Leu Lys Asn Glu Lys Arg Val His Leu Ala Gln Pro Trp 
65                  70                  75                  80  

Ala Ser Gly Pro Arg Phe Phe Pro Leu Pro Gln Gly Gln Ile Ala Val 
                85                  90                  95      

Thr Leu Arg Asp Ala Gln Ala Cys Phe Asn Leu Asn Ala Leu Ala Gln 
            100                 105                 110         

Pro Thr Thr Ala Ser Arg Pro Leu Ala Val Gln Gln Leu Ile Ala Leu 
        115                 120                 125             

Ile Ser Arg Leu Asp Val Pro Ala Tyr Arg Ala Glu Leu Ile Ala Glu 
    130                 135                 140                 

Ser Leu Trp Glu Phe Ile Asp Glu Asp Arg Ser Val Gln Thr Arg Leu 
145                 150                 155                 160 

Gly Arg Glu Asp Ser Glu Tyr Leu Ala Arg Ser Val Pro Phe Tyr Ala 
                165                 170                 175     

Ala Asn Gln Pro Leu Ala Asp Ile Ser Glu Met Arg Val Val Gln Gly 
            180                 185                 190         

Met Asp Ala Gly Leu Tyr Gln Lys Leu Lys Pro Leu Val Cys Ala Leu 
        195                 200                 205             

Pro Met Ala Arg Gln Gln Ile Asn Ile Asn Thr Leu Asp Val Thr Gln 
    210                 215                 220                 

Ser Val Ile Leu Glu Ala Leu Phe Asp Pro Trp Leu Ser Pro Val Gln 
225                 230                 235                 240 

Ala Arg Ala Leu Leu Gln Gln Arg Pro Ala Lys Gly Trp Glu Asp Val 
                245                 250                 255     

Asp Gln Phe Leu Ala Gln Pro Leu Leu Ala Asp Val Asp Glu Arg Thr 
            260                 265                 270         

Lys Lys Gln Leu Lys Thr Ile Leu Ser Val Asp Ser Asn Tyr Phe Trp 
        275                 280                 285             

Leu Arg Ser Asp Ile Thr Val Asn Glu Ile Glu Leu Thr Met Asn Ser 
    290                 295                 300                 

Leu Ile Val Arg Met Gly Pro Gln His Phe Ser Val Leu Trp His Gln 
305                 310                 315                 320 

Thr Gly Glu Ser Glu 
                325 

<210>   31
<211>   1520
<212>   PRT
<213>   Escherichia coli

<400>   31
Met Asn Lys Lys Phe Lys Tyr Lys Lys Ser Leu Leu Ala Ala Ile Leu 
1               5                   10                  15      

Ser Ala Thr Leu Leu Ala Gly Cys Asp Gly Gly Gly Ser Gly Ser Ser 
            20                  25                  30          

Ser Asp Thr Pro Ser Val Asp Ser Gly Ser Gly Thr Leu Pro Glu Val 
        35                  40                  45              

Lys Pro Asp Pro Thr Pro Thr Pro Glu Pro Thr Pro Glu Pro Thr Pro 
    50                  55                  60                  

Asp Pro Glu Pro Thr Pro Asp Pro Thr Pro Asp Pro Glu Pro Thr Pro 
65                  70                  75                  80  

Glu Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu 
                85                  90                  95      

Gly Gly Ser Gln Arg Val Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser 
            100                 105                 110         

Asp Gly Phe Thr Phe Thr Pro Gly Asn Thr Val Ser Cys Val Val Gly 
        115                 120                 125             

Ser Thr Thr Ile Ala Thr Phe Asn Thr Gln Ser Glu Ala Ala Arg Ser 
    130                 135                 140                 

Leu Arg Ala Val Asp Lys Val Ser Phe Ser Leu Glu Asp Ala Gln Glu 
145                 150                 155                 160 

Leu Ala Asn Ser Glu Asn Lys Lys Thr Asn Ala Ile Ser Leu Val Thr 
                165                 170                 175     

Ser Ser Asp Ser Cys Pro Ala Asp Ala Glu Gln Leu Cys Leu Thr Phe 
            180                 185                 190         

Ser Ser Val Val Asp Arg Ala Arg Phe Glu Lys Leu Tyr Lys Gln Ile 
        195                 200                 205             

Asp Leu Ala Thr Asp Asn Phe Ser Lys Leu Val Asn Glu Glu Val Glu 
    210                 215                 220                 

Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Thr Val 
225                 230                 235                 240 

Val Pro Val Thr Thr Glu Gly Thr Lys Pro Asp Leu Asn Ala Ser Phe 
                245                 250                 255     

Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu Ile 
            260                 265                 270         

Ile Leu Ser Glu Gly Gln Leu Val Asp Ser Leu Gly Asn Gly Val Ala 
        275                 280                 285             

Gly Val Asp Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Asp Glu Asn 
    290                 295                 300                 

Gly Lys Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile Asp 
305                 310                 315                 320 

Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala Leu 
                325                 330                 335     

Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu Ile 
            340                 345                 350         

His Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val Pro Asp 
        355                 360                 365             

Asp Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu Ile 
    370                 375                 380                 

Ile Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Asp Glu Gly Asp Gln 
385                 390                 395                 400 

Asn Val Val Leu Pro Asn Glu Phe Ile Glu Gln Phe Lys Thr Gly Gln 
                405                 410                 415     

Ala Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly Cys Asn 
            420                 425                 430         

Glu Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly Gln 
        435                 440                 445             

Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn Tyr Gln 
    450                 455                 460                 

Ser Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr Gly 
465                 470                 475                 480 

Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn Ser 
                485                 490                 495     

Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu Ala 
            500                 505                 510         

Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile Thr 
        515                 520                 525             

Glu Ala Pro Ser Ile Val Gln Pro Glu Asn Val Thr Arg Asp Thr Ala 
    530                 535                 540                 

Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Glu Gly Lys 
545                 550                 555                 560 

Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys Pro 
                565                 570                 575     

Asn Gly Tyr Ser Trp Gly Gly Gly Val Asn Ser Lys Gly Glu Cys Thr 
            580                 585                 590         

Leu Ser Gly Asp Ser Asp Asp Met Lys His Phe Met Gln Asn Val Leu 
        595                 600                 605             

Arg Tyr Leu Ser Asn Asp Ile Trp Gln Pro Asn Thr Lys Ser Ile Met 
    610                 615                 620                 

Thr Val Gly Thr Asn Leu Glu Asn Val Tyr Phe Lys Lys Ala Gly Gln 
625                 630                 635                 640 

Val Leu Gly Asn Ser Ala Pro Phe Ala Phe His Glu Asp Phe Thr Gly 
                645                 650                 655     

Ile Thr Val Lys Gln Leu Thr Ser Tyr Gly Asp Leu Asn Pro Glu Glu 
            660                 665                 670         

Ile Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Trp Ser 
        675                 680                 685             

Gly Asp Pro Tyr Ala Val Pro Leu Arg Ala Asp Thr Ser Lys Pro Lys 
    690                 695                 700                 

Leu Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn Lys Gly 
705                 710                 715                 720 

Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu Glu 
                725                 730                 735     

Ser Ala Ser Ser Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser Met 
            740                 745                 750         

Ala Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro Asp 
        755                 760                 765             

Arg Val Arg Gln Arg Arg Ala Thr Gly Ile Trp Val Tyr Glu Arg Tyr 
    770                 775                 780                 

Pro Ala Ala Asp Gly Ala Gln Pro Pro Tyr Thr Ile Asp Pro Asn Thr 
785                 790                 795                 800 

Gly Glu Val Thr Trp Lys Tyr Gln Gln Asp Asn Lys Pro Asp Asp Lys 
                805                 810                 815     

Pro Lys Leu Glu Val Ala Ser Trp Gln Glu Glu Val Glu Gly Lys Gln 
            820                 825                 830         

Val Thr Arg Tyr Ala Phe Ile Asp Glu Ala Glu Tyr Thr Thr Glu Glu 
        835                 840                 845             

Ser Leu Glu Ala Ala Lys Ala Lys Ile Phe Glu Lys Phe Pro Gly Leu 
    850                 855                 860                 

Gln Glu Cys Lys Asp Ser Thr Tyr His Tyr Glu Ile Asn Cys Leu Glu 
865                 870                 875                 880 

Arg Arg Pro Gly Thr Asp Val Pro Val Thr Gly Gly Met Tyr Val Pro 
                885                 890                 895     

Arg Tyr Thr Gln Leu Asn Leu Asp Ala Asp Thr Ala Lys Ala Met Val 
            900                 905                 910         

Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu 
        915                 920                 925             

Leu Tyr Phe Arg Thr Lys Gly Ser Lys Gly Glu Arg Leu Asn Ser Val 
    930                 935                 940                 

Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Asp 
945                 950                 955                 960 

Thr Lys Tyr Arg Tyr Glu Glu Gly Lys Glu Asp Glu Leu Gly Phe Lys 
                965                 970                 975     

Thr Phe Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asp Ala Tyr Ala Gly 
            980                 985                 990         

Gly Thr Lys Cys Ser Ala Asp Leu Lys Lys Ser Leu Val Asp Asn Asn 
        995                 1000                1005            

Met Ile Tyr Gly Asp Gly Ser Ser Lys Ala Gly Met Met Asn Pro Ser 
    1010                1015                1020                

Tyr Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly 
1025                1030                1035                1040

Arg Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro 
                1045                1050                1055    

Gly Ser Val Ser Ala Lys Gly Glu Ser Val Thr Glu Asn Ile Ser Leu 
            1060                1065                1070        

Tyr Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly 
        1075                1080                1085            

Leu Trp Ala Pro Ala Gln Gln Asp Val Thr Ile Lys Ser Ser Ala Ser 
    1090                1095                1100                

Val Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg 
1105                1110                1115                1120

Glu Lys His Glu Val Ala Leu Asn Arg Pro Pro Arg Val Thr Lys Thr 
                1125                1130                1135    

Tyr Thr Leu Glu Ala Asn Gly Glu Val Thr Phe Lys Val Pro Tyr Gly 
            1140                1145                1150        

Gly Leu Ile Tyr Ile Lys Gly Asp Ser Lys Asp Asp Val Ser Ala Asn 
        1155                1160                1165            

Phe Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Glu 
    1170                1175                1180                

Trp Lys Asn Asp Leu Asp Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser 
1185                1190                1195                1200

Ala Ser Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Glu Ala Ser Asn 
                1205                1210                1215    

Phe Thr Gly Gly Val Ala Glu Phe Ala Lys Asp Leu Asp Thr Phe Ala 
            1220                1225                1230        

Ser Ser Met Asn Asp Phe Tyr Gly Arg Asn Asp Glu Asp Gly Lys His 
        1235                1240                1245            

Arg Met Phe Thr Tyr Lys Asn Leu Thr Gly His Lys His Arg Phe Thr 
    1250                1255                1260                

Asn Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val 
1265                1270                1275                1280

Met Asn Ser Ser Phe Ser Thr Asn Ser Thr Thr Leu Pro Thr Thr Pro 
                1285                1290                1295    

Leu Asn Asp Trp Leu Ile Trp Ala Ala Val Gly Ala Asn Ala Ala Glu 
            1300                1305                1310        

Thr Pro Leu Asn Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu 
        1315                1320                1325            

Ala Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala 
    1330                1335                1340                

Asp Asp Ile Thr Val Ala Pro Glu Tyr Leu Asp Glu Ser Asn Gly Gln 
1345                1350                1355                1360

Ala Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln 
                1365                1370                1375    

Leu Lys Glu Trp Ala Glu Glu Asn Phe Asp Ile Lys Gln Trp Tyr Pro 
            1380                1385                1390        

Asp Gly Glu Leu Pro Lys Phe Tyr Ser Asp Arg Lys Gly Met Lys Gly 
        1395                1400                1405            

Trp Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Asp Val 
    1410                1415                1420                

Gly Asn Ser Thr Phe Gly Gly Lys Asn Tyr Cys Ala Glu Ser Asn Gly 
1425                1430                1435                1440

Asn Ala Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln Ala 
                1445                1450                1455    

Asp Leu Ser Glu Phe Phe Lys Lys Trp Asn Pro Gly Ala Ser Ala Tyr 
            1460                1465                1470        

Gln Leu Pro Gly Ala Thr Glu Met Ser Phe Gln Gly Gly Val Ser Ser 
        1475                1480                1485            

Ser Ala Tyr Ser Thr Leu Ala Ser Leu Lys Leu Pro Lys Pro Glu Lys 
    1490                1495                1500                

Gly Pro Glu Thr Ile Asn Lys Val Thr Glu His Lys Met Ser Ala Glu 
1505                1510                1515                1520

<210>   32
<211>   28
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   32
tgatgccgtt ttcttaagaa tggaggaa                                     28

<210>   33
<211>   19
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   33
gagccagaac ctgttccta                                               19

<210>   34
<211>   21
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   34
gtaaagccat cgctggattc a                                            21

<210>   35
<211>   20
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   35
ccacctcttc attgaccagc                                              20

<210>   36
<211>   20
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   36
cggaacagtt ttatcagtat                                              20

<210>   37
<211>   18
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   37
ccccgcgaac ttcatcac                                                18

<210>   38
<211>   21
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   38
gcaaggtctt tgccgagtat c                                            21

<210>   39
<211>   21
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   39
tgataaaaac tactggctgg c                                            21

<210>   40
<211>   19
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   40
ggttaccgat aaccatcag                                               19

<210>   41
<211>   19
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   41
gcagatacca gcaaaccga                                               19

<210>   42
<211>   23
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   42
tcatcacgtt ttccatgatc agc                                          23

<210>   43
<211>   22
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   43
gcggatttag gcaccaacat tc                                           22

<210>   44
<211>   22
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   44
gaatgttggt gcctaaatcc gc                                           22

<210>   45
<211>   23
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   45
gtgaacgttt taaagcccag ctc                                          23

<210>   46
<211>   23
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   46
aactatatgg aaaaaccgct gac                                          23

<210>   47
<211>   20
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   47
aaagcgccgt tctataaaga                                              20

<210>   48
<211>   20
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   48
ttatagaacg gcgcttttac                                              20

<210>   49
<211>   20
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   49
catcaccgat ggagatctgc                                              20

<210>   50
<211>   21
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   50
aagatgaacc gtgtcgctga c                                            21

<210>   51
<211>   21
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   51
ctggaacctg ttccagttga t                                            21

<210>   52
<211>   21
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   52
atcaactgga acaggttcca g                                            21

<210>   53
<211>   23
<212>   DNA
<213>   Primer

<400>   53
tattgctgaa aaacatcaaa aag                                          23

<210>   54
<211>   1521
<212>   PRT
<213>   Escherichia coli

<220>
<221>   misc_feature
<222>   37, 42, 44, 55, 71, 121, 122, 124, 127, 129, 130, 150, 164, 166, 170, 173, 179, 186, 189, 192, 197, 198, 199, 200, 203, 204, 213, 214, 215, 217, 240, 247, 279, 284, 286, 289, 296, 303, 307, 358, 359, 361, 370, 397, 400, 402, 404, 414, 430, 462, 465, 468, 559, 583, 588, 589, 595, 596, 598, 603, 616, 618, 621, 623, 624, 632, 633, 638, 643, 648, 650, 653, 656, 659, 661, 662, 664, 674, 688, 690, 695, 741, 774, 788, 791, 792, 793, 799, 800, 805, 810, 811, 826, 828, 830, 834, 844, 845, 846, 848, 849, 852, 856, 859, 860, 861, 866, 871, 872, 877, 882, 887, 898, 903, 905, 937, 943, 961, 962, 963, 968, 969, 971, 992, 993, 996, 1000, 1009, 1014, 1015, 1017, 1059, 1062, 1063, 1066, 1070, 1096, 1101, 1103, 1105, 1133, 1139, 1141, 1143, 1145, 1147, 1163, 1164, 1166, 1169, 1185, 1189, 1202, 1203, 1214, 1218, 1222, 1223, 1227, 1244, 1246, 1256, 1317, 1356, 1390, 1394, 1396, 1399, 1403, 1424, 1427, 1428, 1429, 1432, 1433, 1479, 1493, 1497, 1499, 1505, 1512
<223>   'Xaa' is any amino acid

<220>
<221>   misc_feature
<222>   534
<223>   'Xaa' is Ile or Leu

<400>   54
Met Asn Lys Lys Phe Lys Tyr Lys Lys Ser Leu Leu Ala Ala Ile Leu 
1               5                   10                  15      

Ser Ala Thr Leu Leu Ala Gly Cys Asp Gly Gly Gly Ser Gly Ser Ser 
            20                  25                  30          

Ser Asp Thr Pro Xaa Val Asp Ser Gly Xaa Gly Xaa Leu Pro Glu Val 
        35                  40                  45              

Lys Pro Asp Pro Thr Pro Xaa Pro Glu Pro Thr Pro Glu Pro Thr Pro 
    50                  55                  60                  

Asp Pro Glu Pro Thr Pro Xaa Pro Thr Pro Asp Pro Glu Pro Thr Pro 
65                  70                  75                  80  

Glu Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu 
                85                  90                  95      

Gly Gly Ser Gln Arg Val Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser 
            100                 105                 110         

Asp Gly Phe Thr Phe Thr Pro Gly Xaa Xaa Val Xaa Cys Val Xaa Gly 
        115                 120                 125             

Xaa Xaa Thr Thr Ile Ala Thr Phe Asx Thr Gln Ser Glu Ala Ala Arg 
    130                 135                 140                 

Ser Leu Arg Ala Val Xaa Lys Val Ser Phe Ser Leu Glu Asp Ala Gln 
145                 150                 155                 160 

Glu Leu Ala Xaa Ser Xaa Asx Lys Lys Xaa Asn Ala Xaa Ser Leu Val 
                165                 170                 175     

Thr Ser Xaa Asx Ser Cys Pro Ala Asx Xaa Glu Gln Xaa Cys Leu Xaa 
            180                 185                 190         

Phe Ser Ser Val Xaa Xaa Xaa Xaa Arg Phe Xaa Xaa Leu Tyr Lys Gln 
        195                 200                 205             

Ile Asp Leu Ala Xaa Xaa Xaa Phe Xaa Lys Leu Val Asn Glu Glu Val 
    210                 215                 220                 

Glu Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Xaa 
225                 230                 235                 240 

Val Val Pro Val Thr Thr Xaa Gly Thr Lys Pro Asp Leu Asn Ala Ser 
                245                 250                 255     

Phe Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu 
            260                 265                 270         

Ile Ile Leu Ser Glu Gly Xaa Leu Val Asp Ser Xaa Gly Xaa Gly Val 
        275                 280                 285             

Xaa Gly Val Asx Tyr Tyr Thr Xaa Ser Gly Arg Gly Val Thr Xaa Glu 
    290                 295                 300                 

Asn Gly Xaa Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile 
305                 310                 315                 320 

Asp Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala 
                325                 330                 335     

Leu Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu 
            340                 345                 350         

Ile His Arg Tyr Ser Xaa Xaa Gly Xaa Asn Asx Thr Arg Val Val Pro 
        355                 360                 365             

Asp Xaa Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu 
    370                 375                 380                 

Ile Ile Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Xaa Glu Gly Xaa 
385                 390                 395                 400 

Gln Xaa Val Xaa Leu Pro Asn Glu Phe Ile Glu Gln Phe Xaa Thr Gly 
                405                 410                 415     

Gln Ala Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Xaa Gly Cys 
            420                 425                 430         

Asn Glu Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly 
        435                 440                 445             

Gln Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Xaa Asx Tyr 
    450                 455                 460                 

Xaa Ser Val Xaa Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr 
465                 470                 475                 480 

Gly Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn 
                485                 490                 495     

Ala Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu 
            500                 505                 510         

Ala Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile 
        515                 520                 525             

Thr Glu Ala Pro Ser Xaa Val Glx Pro Glu Asn Val Thr Arg Asp Thr 
    530                 535                 540                 

Ala Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Xaa Gly 
545                 550                 555                 560 

Lys Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys 
                565                 570                 575     

Pro Asn Gly Tyr Ser Trp Xaa Gly Gly Val Asn Xaa Xaa Gly Glx Cys 
            580                 585                 590         

Thr Leu Xaa Xaa Asp Xaa Asp Asp Met Lys Xaa Phe Met Glx Asn Val 
        595                 600                 605             

Leu Arg Tyr Leu Ser Asx Asp Xaa Trp Xaa Pro Asx Xaa Lys Xaa Xaa 
    610                 615                 620                 

Met Thr Val Gly Thr Asn Leu Xaa Xaa Val Tyr Phe Lys Xaa His Gly 
625                 630                 635                 640 

Gln Val Xaa Gly Asn Ser Ala Xaa Phe Xaa Phe His Xaa Asp Phe Xaa 
                645                 650                 655     

Gly Ile Xaa Val Xaa Xaa Leu Xaa Ser Tyr Gly Asp Leu Asx Pro Glx 
            660                 665                 670         

Glu Xaa Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Xaa 
        675                 680                 685             

Gly Xaa Asp Pro Tyr Ala Xaa Pro Leu Arg Ala Asp Thr Ser Lys Pro 
    690                 695                 700                 

Lys Leu Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn Lys 
705                 710                 715                 720 

Gly Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu 
                725                 730                 735     

Glu Ser Ala Ser Xaa Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser 
            740                 745                 750         

Met Ala Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro 
        755                 760                 765             

Asx Arg Val Arg Gln Xaa Arg Ala Thr Gly Ile Trp Val Tyr Glu Arg 
    770                 775                 780                 

Tyr Pro Ala Xaa Asp Gly Xaa Xaa Xaa Pro Tyr Thr Ile Asp Xaa Xaa 
785                 790                 795                 800 

Thr Gly Glu Val Xaa Trp Lys Tyr Gln Xaa Xaa Asn Lys Pro Asp Asp 
                805                 810                 815     

Lys Pro Lys Leu Glu Val Ala Ser Trp Xaa Glu Xaa Val Xaa Gly Lys 
            820                 825                 830         

Gln Xaa Thr Arg Tyr Ala Phe Ile Asp Glu Ala Xaa Xaa Xaa Thr Xaa 
        835                 840                 845             

Xaa Ser Leu Xaa Ala Ala Lys Xaa Lys Ile Xaa Xaa Xaa Phe Pro Gly 
    850                 855                 860                 

Leu Xaa Glu Cys Lys Asp Xaa Xaa Tyr His Tyr Glu Xaa Asn Cys Leu 
865                 870                 875                 880 

Glu Xaa Arg Pro Gly Thr Xaa Val Pro Val Thr Gly Gly Met Tyr Val 
                885                 890                 895     

Pro Xaa Tyr Thr Gln Leu Xaa Leu Xaa Ala Asp Thr Ala Lys Ala Met 
            900                 905                 910         

Val Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His 
        915                 920                 925             

Glu Leu Tyr Phe Arg Thr Asn Gly Xaa Lys Gly Glu Arg Leu Xaa Ser 
    930                 935                 940                 

Val Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn 
945                 950                 955                 960 

Xaa Xaa Xaa Tyr Arg Tyr Glu Xaa Xaa Lys Xaa Asp Glu Leu Gly Phe 
                965                 970                 975     

Lys Thr Phe Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asp Ala Tyr Xaa 
            980                 985                 990         

Xaa Gly Thr Xaa Cys Ser Ala Xaa Leu Lys Lys Ser Leu Val Asp Asn 
        995                 1000                1005            

Xaa Met Ile Tyr Gly Xaa Xaa Ser Xaa Lys Ala Gly Met Met Asn Pro 
    1010                1015                1020                

Ser Tyr Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu 
1025                1030                1035                1040

Gly Arg Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr 
                1045                1050                1055    

Pro Gly Xaa Val Ser Xaa Xaa Gly Glx Xaa Val Thr Glu Xaa Ile Ser 
            1060                1065                1070        

Leu Tyr Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr 
        1075                1080                1085            

Gly Leu Trp Ala Pro Ala Gln Xaa Glu Val Thr Ile Xaa Ser Xaa Ala 
    1090                1095                1100                

Xaa Val Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly 
1105                1110                1115                1120

Arg Glu Lys His Glu Val Ala Leu Asn Arg Pro Pro Xaa Val Thr Lys 
                1125                1130                1135    

Thr Tyr Xaa Leu Xaa Ala Xaa Gly Xaa Val Xaa Phe Lys Val Pro Tyr 
            1140                1145                1150        

Gly Gly Leu Ile Tyr Ile Lys Gly Asx Ser Xaa Xaa Asx Xaa Ser Ala 
        1155                1160                1165            

Xaa Phe Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly 
    1170                1175                1180                

Xaa Trp Lys Asn Xaa Leu Asx Ser Pro Ala Pro Leu Gly Glu Leu Glu 
1185                1190                1195                1200

Ser Xaa Xaa Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Xaa Ala Ser 
                1205                1210                1215    

Asn Xaa Thr Gly Gly Xaa Xaa Glx Phe Ala Xaa Asp Leu Asp Thr Phe 
            1220                1225                1230        

Ala Ser Ser Met Asn Asp Phe Tyr Gly Arg Asx Xaa Glu Xaa Gly Lys 
        1235                1240                1245            

His Arg Met Phe Thr Tyr Lys Xaa Leu Thr Gly His Lys His Arg Phe 
    1250                1255                1260                

Thr Asn Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro 
1265                1270                1275                1280

Val Met Asn Ser Ser Phe Ser Thr Asn Ser Thr Thr Leu Pro Thr Thr 
                1285                1290                1295    

Pro Leu Asn Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala 
            1300                1305                1310        

Glu Thr Pro Leu Xaa Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val 
        1315                1320                1325            

Leu Ala Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val 
    1330                1335                1340                

Ala Asp Asp Ile Thr Val Ala Pro Glu Tyr Leu Xaa Glu Ser Asn Gly 
1345                1350                1355                1360

Gln Ala Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala 
                1365                1370                1375    

Gln Leu Lys Glu Trp Ala Glu Lys Asn Phe Asp Ile Lys Xaa Trp Tyr 
            1380                1385                1390        

Pro Xaa Gly Xaa Leu Pro Xaa Phe Tyr Ser Xaa Arg Glu Gly Met Lys 
        1395                1400                1405            

Gly Trp Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Xaa 
    1410                1415                1420                

Val Gly Xaa Xaa Xaa Phe Gly Xaa Xaa Asn Tyr Cys Ala Glu Ser Asn 
1425                1430                1435                1440

Gly Asn Ala Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln 
                1445                1450                1455    

Thr Asp Leu Ser Glu Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn Ala 
            1460                1465                1470        

Tyr Gln Leu Pro Gly Ala Xaa Glu Met Ser Phe Glu Gly Gly Val Ser 
        1475                1480                1485            

Gln Ser Ala Tyr Xaa Thr Leu Ala Xaa Leu Xaa Leu Pro Lys Pro Glx 
    1490                1495                1500                

Xaa Gly Pro Glu Thr Ile Asn Xaa Val Thr Glu His Lys Met Ser Ala 
1505                1510                1515                1520

Glu 
    

<210>   55
<211>   1538
<212>   PRT
<213>   Escherichia coli

<220>
<221>   misc_feature
<222>   31, 37, 38, 42, 44, 47, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 83, 84, 85, 88, 89, 90, 91, 94, 101, 106, 108, 111, 112, 113, 116, 118, 125, 126, 128, 129, 131, 134, 136, 137, 157, 167, 171, 173, 177, 180, 185, 186, 193, 196, 199, 204, 205, 206, 207, 210, 211, 217, 219, 220, 221, 222, 224, 247, 248, 251, 254, 257, 272, 278, 282, 286, 289, 291, 293, 296, 303, 304, 310, 314, 316, 322, 363, 365, 366, 367, 368, 370, 371, 373, 376, 377, 380, 384, 401, 402, 404, 407, 409, 410, 411, 412, 413, 415, 420, 421, 422, 425, 426, 434, 435, 436, 437, 441, 442, 449, 454, 456, 459, 469, 470, 472, 475, 499, 504, 531, 543, 544, 550, 553, 566, 590, 592, 595, 596, 601, 602, 603, 605, 610, 622, 623, 625, 628, 630, 631, 639, 640, 645, 646, 650, 652, 653, 655, 657, 660, 663, 666, 667, 668, 669, 670, 671, 679, 680, 681, 695, 696, 697, 701, 702, 714, 725, 730, 748, 757, 769, 778, 781, 783, 784, 785, 794, 795, 796, 797, 798, 799, 800, 806, 807, 809, 810, 812, 817, 818, 819, 821, 823, 833, 835, 837, 839, 841, 842, 843, 844, 849, 851, 852, 853, 855, 856, 857, 859, 863, 864, 866, 867, 868, 870, 873, 874, 876, 878, 879, 884, 889, 891, 893, 894, 897, 899, 900, 901, 902, 903, 906, 909, 914, 916, 924, 929, 946, 948, 949, 954, 955, 965, 972, 973, 974, 976, 978, 979, 980, 982, 998, 1003, 1004, 1007, 1010, 1011, 1014, 1017, 1020, 1025, 1026, 1027, 1028, 1029, 1037, 1067, 1071, 1073, 1074, 1075, 1078, 1082, 1084, 1088, 1103, 1107, 1108, 1109, 1111, 1113, 1115, 1116, 1117, 1119, 1126, 1139, 1145, 1151, 1153, 1155, 1156, 1157, 1159, 1161, 1172, 1175, 1176, 1177, 1178, 1179, 1182, 1186, 1198, 1200, 1201, 1202, 1203, 1204, 1215, 1216, 1221, 1224, 1227, 1229, 1230, 1231, 1234, 1235, 1236, 1238, 1239, 1243, 1244, 1250, 1256, 1260, 1261, 1262, 1264, 1266, 1270, 1271, 1272, 1274, 1281, 1304, 1307, 1312, 1323, 1333, 1343, 1372, 1376, 1400, 1405, 1406, 1410, 1412, 1413, 1416, 1418, 1420, 1422, 1438, 1441, 1443, 1444, 1445, 1446, 1449, 1450, 1460, 1463, 1474, 1478, 1488, 1495, 1496, 1499, 1501, 1502, 1505, 1506, 1510, 1514, 1515, 1516, 1518, 1521, 1522, 1526, 1527, 1529, 1533, 1534, 1536, 1537
<223>   'Xaa' is any amino acid

<220>
<221>   misc_feature
<222>   323, 417, 541
<223>   'Xaa' is Ile or Leu

<400>   55
Met Asn Lys Lys Phe Lys Tyr Lys Lys Ser Leu Leu Ala Ala Ile Leu 
1               5                   10                  15      

Ser Ala Thr Leu Leu Ala Gly Cys Asp Gly Gly Gly Ser Gly Xaa Ser 
            20                  25                  30          

Ser Asp Thr Pro Xaa Xaa Asp Ser Gly Xaa Gly Xaa Leu Pro Xaa Val 
        35                  40                  45              

Lys Pro Asp Pro Thr Pro Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  

Xaa Pro Xaa Xaa Xaa Pro Glu Xaa Xaa Xaa Xaa Pro Val Xaa Thr Lys 
                85                  90                  95      

Thr Gly Tyr Leu Xaa Leu Gly Gly Ser Xaa Arg Xaa Thr Gly Xaa Xaa 
            100                 105                 110         

Xaa Cys Asn Xaa Glu Xaa Ser Asp Gly Phe Thr Phe Xaa Xaa Gly Xaa 
        115                 120                 125             

Xaa Val Xaa Cys Val Xaa Gly Xaa Xaa Thr Thr Ile Ala Thr Phe Asx 
    130                 135                 140                 

Thr Gln Ser Glu Ala Ala Arg Ser Leu Arg Ala Val Xaa Lys Val Ser 
145                 150                 155                 160 

Phe Ser Leu Glu Asp Ala Xaa Glu Leu Ala Xaa Ser Xaa Asx Lys Lys 
                165                 170                 175     

Xaa Asn Ala Xaa Ser Leu Val Thr Xaa Xaa Asx Ser Cys Pro Ala Asx 
            180                 185                 190         

Xaa Glu Gln Xaa Cys Leu Xaa Phe Ser Ser Val Xaa Xaa Xaa Xaa Arg 
        195                 200                 205             

Phe Xaa Xaa Leu Tyr Lys Gln Ile Xaa Leu Xaa Xaa Xaa Xaa Phe Xaa 
    210                 215                 220                 

Lys Leu Val Asn Glu Glu Val Glu Asn Asn Ala Ala Thr Asp Lys Ala 
225                 230                 235                 240 

Pro Ser Thr His Thr Ser Xaa Xaa Val Pro Xaa Thr Thr Xaa Gly Thr 
                245                 250                 255     

Xaa Pro Asp Leu Asn Ala Ser Phe Val Ser Ala Asn Ala Glu Gln Xaa 
            260                 265                 270         

Tyr Gln Tyr Gln Pro Xaa Glu Ile Ile Xaa Ser Glu Gly Xaa Leu Val 
        275                 280                 285             

Xaa Ser Xaa Gly Xaa Gly Val Xaa Gly Val Asx Tyr Tyr Thr Xaa Xaa 
    290                 295                 300                 

Gly Arg Gly Val Thr Xaa Glu Asn Gly Xaa Phe Xaa Phe Ser Trp Gly 
305                 310                 315                 320 

Glu Xaa Xaa Ser Phe Gly Ile Asp Thr Phe Glu Leu Gly Ser Val Arg 
                325                 330                 335     

Gly Asn Lys Ser Thr Ile Ala Leu Thr Glu Leu Gly Asp Glu Val Arg 
            340                 345                 350         

Gly Ala Asn Ile Asp Gln Leu Ile His Arg Xaa Ser Xaa Xaa Xaa Xaa 
        355                 360                 365             

Asn Xaa Xaa Arg Xaa Val Pro Xaa Xaa Val Arg Xaa Val Phe Ala Xaa 
    370                 375                 380                 

Tyr Pro Asn Val Ile Asn Glu Ile Ile Asn Leu Ser Leu Ser Asn Gly 
385                 390                 395                 400 

Xaa Xaa Leu Xaa Glu Gly Xaa Gln Xaa Xaa Xaa Xaa Xaa Asn Xaa Phe 
                405                 410                 415     

Xaa Glu Gln Xaa Xaa Xaa Gly Gln Xaa Xaa Glu Ile Asp Thr Ala Ile 
            420                 425                 430         

Cys Xaa Xaa Xaa Xaa Gly Cys Asn Xaa Xaa Arg Trp Phe Ser Leu Thr 
        435                 440                 445             

Xaa Arg Asn Val Asn Xaa Gly Xaa Ile Gln Xaa Val Ile Asn Lys Leu 
    450                 455                 460                 

Trp Gly Val Asp Xaa Xaa Tyr Xaa Ser Val Xaa Lys Phe His Val Phe 
465                 470                 475                 480 

His Asp Ser Thr Asn Phe Tyr Gly Ser Thr Gly Asn Ala Arg Gly Gln 
                485                 490                 495     

Ala Val Xaa Asn Ile Ser Asn Xaa Ala Phe Pro Ile Leu Met Ala Arg 
            500                 505                 510         

Asn Asp Lys Asn Tyr Trp Leu Ala Phe Gly Glu Lys Arg Ala Trp Asp 
        515                 520                 525             

Lys Asn Xaa Leu Ala Tyr Ile Thr Glu Ala Pro Ser Xaa Val Xaa Xaa 
    530                 535                 540                 

Glu Asn Val Thr Arg Xaa Thr Ala Xaa Phe Asn Leu Pro Phe Ile Ser 
545                 550                 555                 560 

Leu Gly Gln Val Gly Xaa Gly Lys Leu Met Val Ile Gly Asn Pro His 
                565                 570                 575     

Tyr Asn Ser Ile Leu Arg Cys Pro Asn Gly Tyr Ser Trp Xaa Gly Xaa 
            580                 585                 590         

Val Asx Xaa Xaa Gly Glx Cys Thr Xaa Xaa Xaa Asp Xaa Asx Asp Met 
        595                 600                 605             

Lys Xaa Phe Met Glx Asn Val Leu Arg Tyr Leu Ser Asx Xaa Xaa Trp 
    610                 615                 620                 

Xaa Pro Asx Xaa Lys Xaa Xaa Met Thr Val Gly Thr Asn Leu Xaa Xaa 
625                 630                 635                 640 

Val Tyr Phe Lys Xaa Xaa Gly Gln Val Xaa Gly Xaa Xaa Ala Xaa Phe 
                645                 650                 655     

Xaa Phe His Xaa Asp Phe Xaa Gly Ile Xaa Xaa Xaa Xaa Xaa Xaa Ser 
            660                 665                 670         

Tyr Gly Asx Leu Asx Pro Xaa Xaa Xaa Pro Leu Leu Ile Leu Asn Gly 
        675                 680                 685             

Phe Glu Tyr Val Thr Gln Xaa Xaa Xaa Asp Pro Tyr Xaa Xaa Pro Leu 
    690                 695                 700                 

Arg Ala Asp Thr Ser Lys Pro Lys Leu Xaa Gln Gln Asp Val Thr Asp 
705                 710                 715                 720 

Leu Ile Ala Tyr Xaa Asn Lys Gly Gly Xaa Val Leu Ile Met Glu Asn 
                725                 730                 735     

Val Met Ser Asn Leu Lys Glu Glu Ser Ala Ser Xaa Phe Val Arg Leu 
            740                 745                 750         

Leu Asp Ala Ala Xaa Leu Ser Met Ala Leu Asn Lys Ser Val Val Asn 
        755                 760                 765             

Xaa Asp Pro Gln Gly Tyr Pro Asx Arg Xaa Arg Gln Xaa Arg Xaa Xaa 
    770                 775                 780                 

Xaa Ile Trp Val Tyr Glu Arg Tyr Pro Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
785                 790                 795                 800 

Pro Tyr Thr Ile Asx Xaa Xaa Thr Xaa Xaa Val Xaa Trp Lys Tyr Gln 
                805                 810                 815     

Xaa Xaa Xaa Lys Xaa Asp Xaa Lys Pro Lys Leu Glu Val Ala Ser Trp 
            820                 825                 830         

Xaa Glu Xaa Val Xaa Gly Xaa Gln Xaa Xaa Xaa Xaa Ala Phe Ile Asp 
        835                 840                 845             

Xaa Ala Xaa Xaa Xaa Thr Xaa Xaa Xaa Leu Xaa Ala Ala Lys Xaa Xaa 
    850                 855                 860                 

Ile Xaa Xaa Xaa Phe Xaa Gly Leu Xaa Xaa Cys Xaa Asx Xaa Xaa Tyr 
865                 870                 875                 880 

His Tyr Glu Xaa Asn Cys Leu Glu Xaa Arg Xaa Gly Xaa Xaa Val Pro 
                885                 890                 895     

Xaa Thr Xaa Xaa Xaa Xaa Xaa Gly Met Xaa Val Pro Xaa Tyr Thr Gln 
            900                 905                 910         

Leu Xaa Leu Xaa Ala Asp Thr Ala Lys Ala Met Xaa Gln Ala Ala Asp 
        915                 920                 925             

Xaa Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu Leu Tyr Phe Arg 
    930                 935                 940                 

Thr Xaa Gly Xaa Xaa Gly Glu Arg Leu Xaa Xaa Val Asp Leu Glu Arg 
945                 950                 955                 960 

Leu Tyr Gln Asn Xaa Ser Val Trp Leu Trp Asn Xaa Xaa Xaa Tyr Xaa 
                965                 970                 975     

Tyr Xaa Xaa Xaa Lys Xaa Asp Glu Leu Gly Phe Lys Thr Phe Thr Glu 
            980                 985                 990         

Phe Leu Asn Cys Tyr Xaa Asn Asx Ala Tyr Xaa Xaa Gly Thr Xaa Cys 
        995                 1000                1005            

Ser Xaa Xaa Leu Lys Xaa Ser Leu Xaa Asp Asn Xaa Met Ile Tyr Gly 
    1010                1015                1020                

Xaa Xaa Xaa Xaa Xaa Lys Ala Gly Met Met Asn Pro Xaa Tyr Pro Leu 
1025                1030                1035                1040

Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly Arg Ser Trp 
                1045                1050                1055    

Trp Asp Leu Asn Ile Lys Val Asp Val Glu Xaa Tyr Pro Gly Xaa Val 
            1060                1065                1070        

Xaa Xaa Xaa Gly Glx Xaa Val Thr Glx Xaa Ile Xaa Leu Tyr Ser Xaa 
        1075                1080                1085            

Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly Leu Xaa Ala 
    1090                1095                1100                

Pro Ala Xaa Xaa Xaa Val Xaa Ile Xaa Ser Xaa Xaa Xaa Val Xaa Val 
1105                1110                1115                1120

Thr Val Thr Val Ala Xaa Ala Asp Asp Leu Thr Gly Arg Glu Lys His 
                1125                1130                1135    

Glu Val Xaa Leu Asn Arg Pro Pro Xaa Val Thr Lys Thr Tyr Xaa Leu 
            1140                1145                1150        

Xaa Ala Xaa Xaa Xaa Val Xaa Phe Xaa Val Pro Tyr Gly Gly Leu Ile 
        1155                1160                1165            

Tyr Ile Lys Xaa Asx Ser Xaa Xaa Xaa Xaa Xaa Ser Ala Xaa Phe Thr 
    1170                1175                1180                

Phe Xaa Gly Val Val Lys Ala Pro Phe Tyr Lys Asx Gly Xaa Trp Xaa 
1185                1190                1195                1200

Xaa Xaa Xaa Xaa Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser Xaa Xaa 
                1205                1210                1215    

Phe Val Tyr Thr Xaa Pro Lys Xaa Asn Leu Xaa Ala Xaa Xaa Xaa Ser 
            1220                1225                1230        

Asn Xaa Xaa Xaa Gly Xaa Xaa Glx Phe Ala Xaa Xaa Leu Asp Thr Phe 
        1235                1240                1245            

Ala Xaa Ser Met Asn Asp Phe Xaa Gly Arg Asx Xaa Xaa Xaa Gly Xaa 
    1250                1255                1260                

His Xaa Met Phe Thr Xaa Xaa Xaa Leu Xaa Gly His Lys His Arg Phe 
1265                1270                1275                1280

Xaa Asn Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro 
                1285                1290                1295    

Val Met Asn Ser Ser Phe Ser Xaa Asx Ser Xaa Thr Leu Pro Thr Xaa 
            1300                1305                1310        

Pro Leu Asn Asp Trp Leu Ile Trp His Glu Xaa Gly His Asn Ala Ala 
        1315                1320                1325            

Glu Thr Pro Leu Xaa Val Pro Gly Ala Thr Glu Val Ala Asn Xaa Val 
    1330                1335                1340                

Leu Ala Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val 
1345                1350                1355                1360

Ala Asp Asp Ile Thr Val Ala Pro Glu Tyr Leu Xaa Glu Ser Asn Xaa 
                1365                1370                1375    

Gln Ala Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala 
            1380                1385                1390        

Gln Leu Lys Glu Trp Ala Glu Xaa Asn Phe Asp Ile Xaa Xaa Trp Tyr 
        1395                1400                1405            

Pro Xaa Gly Xaa Xaa Leu Pro Xaa Phe Xaa Ser Xaa Arg Xaa Gly Met 
    1410                1415                1420                

Lys Gly Trp Asn Leu Phe Gln Leu Met His Arg Lys Ala Xaa Gly Asp 
1425                1430                1435                1440

Xaa Val Xaa Xaa Xaa Xaa Phe Gly Xaa Xaa Asn Tyr Cys Ala Glu Ser 
                1445                1450                1455    

Asn Gly Asn Xaa Ala Asp Xaa Leu Met Leu Cys Ala Ser Trp Val Ala 
            1460                1465                1470        

Gln Xaa Asp Leu Ser Xaa Phe Phe Lys Lys Trp Asn Pro Gly Ala Xaa 
        1475                1480                1485            

Ala Tyr Gln Leu Pro Gly Xaa Xaa Glu Met Xaa Phe Xaa Xaa Gly Val 
    1490                1495                1500                

Xaa Xaa Ser Ala Tyr Xaa Thr Leu Ala Xaa Xaa Xaa Leu Xaa Lys Pro 
1505                1510                1515                1520

Xaa Xaa Gly Pro Glu Xaa Xaa Asn Xaa Val Thr Glu Xaa Xaa Met Xaa 
                1525                1530                1535    

Xaa Glu 
        

<210>   56
<211>   26
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   immunostimulatory oligonucleotide

<220>
<221>   modified_base
<222>   1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25
<223>   'n' is 'i' (Inosine)

<400>   56
ncncncncnc ncncncncnc ncncnc                                       26

<210>   57
<211>   11
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   polycationic oligopeptide

<400>   57
Lys Leu Lys Leu Leu Leu Leu Leu Lys Leu Lys 
1               5                   10      

