                         SEQUENCE LISTING

<110>  INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
       MERCIER, Raphal
       CRISMANI, Wayne
 
<120>  AUGMENTATION DE LA RECOMBINAISON MEIOTIQUE CHEZ LES PLANTES PAR 
       INHIBITION DE LA PROTEINE FANCM

<130>  MJP/llF539/153WO

<160>  1     

<170>  PatentIn version 3.4

<210>  1
<211>  1390
<212>  PRT
<213>  Arabidopsis thaliana


<220>
<221>  DOMAIN
<222>  (129)..(272)
<223>  Domaine hlicase DEXDc

<220>
<221>  DOMAIN
<222>  (445)..(570)
<223>  Domaine hlicase HELICc

<400>  1

Met Gly Ser Arg Val Pro Ile Glu Thr Ile Glu Glu Asp Gly Glu Phe 
1               5                   10                  15      


Asp Trp Glu Ala Ala Val Lys Glu Ile Asp Leu Ala Cys Leu Lys Thr 
            20                  25                  30          


Thr Asn Ala Ser Ser Ser Ser Ser Ser His Phe Thr Pro Leu Ala Asn 
        35                  40                  45              


Pro Pro Ile Thr Ala Asn Leu Thr Lys Pro Pro Ala Lys Arg Gln Ser 
    50                  55                  60                  


Thr Leu Asp Lys Phe Ile Gly Arg Thr Glu His Lys Pro Glu Asn His 
65                  70                  75                  80  


Gln Val Val Ser Glu Cys Gly Val Asn Asp Asn Asp Asn Ser Pro Leu 
                85                  90                  95      


Val Gly Ile Asp Pro Glu Ala Ala Lys Thr Trp Ile Tyr Pro Gly Phe 
            100                 105                 110         


Val Pro Leu Arg Asp Tyr Gln Phe Ala Ile Thr Lys Thr Ala Leu Phe 
        115                 120                 125             


Ser Asn Thr Leu Val Ala Leu Pro Thr Gly Leu Gly Lys Thr Leu Ile 
    130                 135                 140                 


Ala Ala Val Val Met Tyr Asn Tyr Phe Arg Trp Phe Pro Gln Gly Lys 
145                 150                 155                 160 


Ile Val Phe Ala Ala Pro Ser Arg Pro Leu Val Met Gln Gln Ile Glu 
                165                 170                 175     


Ala Cys His Asn Ile Val Gly Ile Pro Gln Glu Trp Thr Ile Asp Leu 
            180                 185                 190         


Thr Gly Gln Thr Cys Pro Ser Lys Arg Ala Phe Leu Trp Lys Ser Lys 
        195                 200                 205             


Arg Val Phe Phe Val Thr Pro Gln Val Leu Glu Lys Asp Ile Gln Ser 
    210                 215                 220                 


Gly Thr Cys Leu Thr Asn Tyr Leu Val Cys Leu Val Ile Asp Glu Ala 
225                 230                 235                 240 


His Arg Ala Leu Gly Asn Tyr Ser Tyr Cys Val Val Val Arg Glu Leu 
                245                 250                 255     


Met Ala Val Pro Ile Gln Leu Arg Ile Leu Ala Leu Thr Ala Thr Pro 
            260                 265                 270         


Gly Ser Lys Thr Gln Ala Ile Gln Gly Ile Ile Asp Asn Leu Gln Ile 
        275                 280                 285             


Ser Thr Leu Glu Tyr Arg Asn Glu Ser Asp His Asp Val Cys Pro Tyr 
    290                 295                 300                 


Val His Asp Arg Lys Leu Glu Val Ile Glu Val Pro Leu Gly Gln Asp 
305                 310                 315                 320 


Ala Asp Asp Val Ser Lys Arg Leu Phe His Val Ile Arg Pro Tyr Ala 
                325                 330                 335     


Val Arg Leu Lys Asn Phe Gly Val Asn Leu Asn Arg Asp Ile Gln Thr 
            340                 345                 350         


Leu Ser Pro His Glu Val Leu Met Ala Arg Asp Lys Phe Arg Gln Ala 
        355                 360                 365             


Pro Leu Pro Gly Leu Pro His Val Asn His Gly Asp Val Glu Ser Cys 
    370                 375                 380                 


Phe Ala Ala Leu Ile Thr Leu Tyr His Ile Arg Lys Leu Leu Ser Ser 
385                 390                 395                 400 


His Gly Ile Arg Pro Ala Tyr Glu Met Leu Glu Glu Lys Leu Lys Glu 
                405                 410                 415     


Gly Pro Phe Ala Arg Leu Met Ser Lys Asn Glu Asp Ile Arg Met Thr 
            420                 425                 430         


Lys Leu Leu Met Gln Gln Arg Leu Ser His Gly Ala Pro Ser Pro Lys 
        435                 440                 445             


Leu Ser Lys Met Leu Glu Ile Leu Val Asp His Phe Lys Val Lys Asp 
    450                 455                 460                 


Pro Lys Thr Ser Arg Val Ile Ile Phe Ser Asn Phe Arg Gly Ser Val 
465                 470                 475                 480 


Arg Asp Ile Met Asn Ala Leu Ser Asn Ile Gly Asp Met Val Lys Ala 
                485                 490                 495     


Thr Glu Phe Ile Gly Gln Ser Ser Gly Lys Thr Leu Lys Gly Gln Ser 
            500                 505                 510         


Gln Lys Ile Gln Gln Ala Val Leu Glu Lys Phe Arg Ala Gly Gly Phe 
        515                 520                 525             


Asn Val Ile Val Ala Thr Ser Ile Gly Glu Glu Gly Leu Asp Ile Met 
    530                 535                 540                 


Glu Val Asp Leu Val Ile Cys Phe Asp Ala Asn Val Ser Pro Leu Arg 
545                 550                 555                 560 


Met Ile Gln Arg Met Gly Arg Thr Gly Arg Lys Asn Asn Gly Arg Pro 
                565                 570                 575     


Leu Leu Val Leu Ala Cys Glu Gly Ser Glu Lys Asn Ser Tyr Met Arg 
            580                 585                 590         


Lys Gln Ala Ser Gly Arg Ala Ile Lys Lys His Met Arg Asn Gly Gly 
        595                 600                 605             


Thr Asn Ser Phe Asn Phe His Pro Ser Pro Arg Met Ile Pro His Val 
    610                 615                 620                 


Tyr Lys Pro Glu Val Gln His Val Glu Phe Ser Ile Lys Gln Phe Val 
625                 630                 635                 640 


Pro Arg Gly Lys Lys Leu Gln Glu Glu Tyr Ala Thr Glu Thr Pro Ala 
                645                 650                 655     


Phe Gln Lys Lys Leu Thr Pro Ala Glu Thr His Met Leu Ala Lys Tyr 
            660                 665                 670         


Tyr Asn Asn Pro Asp Glu Glu Lys Leu Arg Val Ser Leu Ile Ala Phe 
        675                 680                 685             


Pro His Phe Gln Thr Leu Pro Ser Lys Val His Lys Val Met His Ser 
    690                 695                 700                 


Arg Gln Thr Gly Met Leu Ile Asp Ala Met Gln His Leu Gln Glu Pro 
705                 710                 715                 720 


Thr Phe Ser Glu Gln Ser Lys Ser Phe Phe Thr Glu Phe Arg Ala Pro 
                725                 730                 735     


Leu Gly Glu Arg Glu Glu Leu Asp Thr Gly Leu Arg Val Thr Asn Asp 
            740                 745                 750         


Pro Lys Asp Leu His Ser Val Arg Asp Leu Glu Val Asn Thr Ser Gln 
        755                 760                 765             


Arg Lys Ala Lys Gln Val Glu Ser Pro Thr Ser Thr Leu Glu Thr Thr 
    770                 775                 780                 


Glu Lys Asp Tyr Glu Glu Ser Ser Pro Thr His Arg Tyr Leu Phe Ser 
785                 790                 795                 800 


Ser Glu Cys Ala Ser Val Asp Thr Leu Gly Asn Val Phe Val Met Pro 
                805                 810                 815     


Val Pro Leu Leu Phe Phe Pro Asn Val Leu Glu Ser Asp Asn Thr Pro 
            820                 825                 830         


Leu Pro Lys Thr Glu Lys Gln His Ser Cys Arg Asn Thr Ser His Ile 
        835                 840                 845             


Asp Leu Val Pro Val Asp Thr Ser Glu Lys His Arg Gln Asp Asn Ile 
    850                 855                 860                 


Ser Cys Lys Leu Lys Glu Arg Phe Ser Pro Asp Gly Ala Ser Glu Thr 
865                 870                 875                 880 


Leu Glu Thr His Ser Leu Val Lys Arg Asn Ser Thr Arg Val Gly Glu 
                885                 890                 895     


Asp Asp Val Ala Asn Ser Val Gly Glu Ile Val Leu Ser Ser Asp Glu 
            900                 905                 910         


Asp Asp Cys Glu Gly Leu Glu Leu Ser Pro Arg Leu Thr Asn Phe Ile 
        915                 920                 925             


Lys Ser Gly Ile Val Pro Glu Ser Pro Val Tyr Asp Gln Gly Glu Ala 
    930                 935                 940                 


Asn Arg Glu Glu Asp Leu Glu Phe Pro Gln Leu Ser Ser Pro Met Arg 
945                 950                 955                 960 


Phe Ser Asn Glu Leu Ala Gly Glu Ser Ser Phe Pro Glu Arg Lys Val 
                965                 970                 975     


Gln His Lys Cys Asn Asp Tyr Asn Ile Val Ser Thr Thr Thr Glu Leu 
            980                 985                 990         


Arg Thr Pro Gln Lys Glu Val Gly  Leu Ala Asn Gly Thr  Glu Cys Leu 
        995                 1000                 1005             


Ala Val  Ser Pro Ile Pro Glu  Asp Trp Arg Thr Pro  Leu Ala Asn 
    1010                 1015                 1020             


Leu Thr  Asn Thr Asn Ser Ser  Ala Arg Lys Asp Trp  Arg Val Ser 
    1025                 1030                 1035             


Ser Gly  Glu Lys Leu Glu Thr  Leu Arg Gln Pro Arg  Lys Leu Lys 
    1040                 1045                 1050             


Arg Leu  Arg Arg Leu Gly Asp  Cys Ser Ser Ala Val  Lys Glu Asn 
    1055                 1060                 1065             


Tyr Pro  Gly Ile Thr Glu Ala  Asp His Ile Arg Ser  Arg Ser Arg 
    1070                 1075                 1080             


Gly Lys  Lys His Ile Arg Val  Lys Trp Lys Ser Ala  Glu Ser Trp 
    1085                 1090                 1095             


Phe Thr  Leu Ser Ser Val Ala  Phe Ala Leu Val Thr  Lys Lys Lys 
    1100                 1105                 1110             


Lys Met  Ile Met Asp Asp Asp  Val Gln Val Phe Ile  Asp Glu Glu 
    1115                 1120                 1125             


Ala Glu  Val Ser Ser Gly Ala  Glu Met Ser Ala Asp  Glu Asn Glu 
    1130                 1135                 1140             


Asp Val  Thr Gly Asp Ser Phe  Glu Asp Ser Phe Ile  Asp Asp Gly 
    1145                 1150                 1155             


Thr Met  Pro Thr Ala Asn Thr  Gln Ala Glu Ser Gly  Lys Val Asp 
    1160                 1165                 1170             


Met Met  Ala Val Tyr Arg Tyr  Ile Gln Pro Lys Ile  Ser Phe Phe 
    1175                 1180                 1185             


Tyr Cys  Glu Val Asn Glu Leu  Ile Lys Asn His Lys  Val Ser Phe 
    1190                 1195                 1200             


His Arg  Arg Ser Leu Leu Ser  Gln Ser Pro Leu Pro  Ala Arg Phe 
    1205                 1210                 1215             


Arg Asp  Leu Ala Ala Ser Ser  Leu Ser Pro Tyr Ser  Ala Gly Pro 
    1220                 1225                 1230             


Leu Thr  Arg Ile Asn Glu Ser  Arg Ser Asp Ser Asp  Lys Ser Leu 
    1235                 1240                 1245             


Ser Ser  Leu Arg Thr Pro Lys  Thr Thr Asn Ser Glu  Ser Asn Gln 
    1250                 1255                 1260             


Asp Ala  Met Met Ile Gly Asn  Leu Ser Val Val Gln  Ile Ser Ser 
    1265                 1270                 1275             


Asp Ser  Arg Lys Arg Lys Phe  Ser Leu Cys Asn Ser  Ala Asn Ala 
    1280                 1285                 1290             


Pro Val  Ile Asn Leu Glu Ser  Lys Phe Ala Ala His  Ala Gln Ala 
    1295                 1300                 1305             


Thr Glu  Lys Glu Ser His Glu  Gly Val Arg Ser Asn  Ala Gly Ala 
    1310                 1315                 1320             


Leu Glu  Tyr Asn Asp Asp Asp  Asp Asp Ala Phe Phe  Ala Thr Leu 
    1325                 1330                 1335             


Asp Phe  Asp Ala Met Glu Ala  Gln Ala Thr Leu Leu  Leu Ser Lys 
    1340                 1345                 1350             


Gln Arg  Ser Glu Ala Lys Glu  Lys Glu Asp Ala Thr  Val Ile Pro 
    1355                 1360                 1365             


Asn Pro  Gly Met Gln Arg Ser  Asp Gly Met Glu Lys  Asp Ala Pro 
    1370                 1375                 1380             


Ser Phe  Asp Leu Gly Leu Trp  
    1385                 1390 


