                         SEQUENCE LISTING

<110>  Deutsches Krebsforschungszentrum
 
<120>  B7-H6 therapeutically active monoclonal antibody against B7-H6 
       polypeptide

<130>  DK10314PC

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  1653
<212>  DNA
<213>  Homo sapiens

<400>  1
atggaacaac ggggacagaa cgccccggcc gcttcggggg cccggaaaag gcacggccca       60

ggacccaggg aggcgcgggg agccaggcct gggccccggg tccccaagac ccttgtgctc      120

gttgtcgccg cggtcctgct gttggtctca gctgagtctg ctctggaatc cgatctgaaa      180

gtagagatga tggcaggggg gactcagatc acacccctga atgacaatgt caccatattc      240

tgcaatatct tttattccca acccctcaac atcacgtcta tgggtatcac ctggttttgg      300

aagagtctga cgtttgacaa agaagtcaaa gtctttgaat tttttggaga tcaccaagag      360

gcattccgac ctggagccat tgtgtctcca tggaggctga agagtgggga cgcctcactg      420

cggctgcctg gaatccagct ggaggaagca ggagagtacc gatgtgaggt ggtggtcacc      480

cctctgaagg cacagggaac agtccagctt gaagttgtgg cttccccagc cagcagattg      540

ttgctggatc aagtgggcat gaaagagaat gaagacaaat atatgtgtga gtcaagtggg      600

ttctacccag aggctattaa tataacatgg gagaagcaga cccagaagtt tccccatccc      660

atagagattt ctgaggatgt catcactggt cccaccatca agaatatgga tggcacattt      720

aatgtcacta gctgcttgaa gctgaactcc tctcaggaag accctgggac tgtctaccag      780

tgtgtggtac ggcatgcgtc cttgcatacc cccttgagga gcaactttac cctgactgct      840

gctcggcaca gtctttctga aactgagaag acagataatt tttccattca ttggtggcct      900

gatatcactc acacatgccc accgtgccca gcacctgaag ccgagggcgc gccgtcagtc      960

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca     1020

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac     1080

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac     1140

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1200

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1260

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1320

aaccaggtca gcctgcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1380

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg     1440

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1500

ctctccctgt ctccgggtaa acatatggga ggtgacgaaa agaccaccgg ctggcgcggc     1560

ggccacgtgg tggaaggcct ggccggcgaa ctggaacagc tgcgcgcccg cctggaacac     1620

cacccacagg gccagcgcga accatgactc gag                                  1653


<210>  2
<211>  548
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Gln Arg Gly Gln Asn Ala Pro Ala Ala Ser Gly Ala Arg Lys 
1               5                   10                  15      


Arg His Gly Pro Gly Pro Arg Glu Ala Arg Gly Ala Arg Pro Gly Pro 
            20                  25                  30          


Arg Val Pro Lys Thr Leu Val Leu Val Val Ala Ala Val Leu Leu Leu 
        35                  40                  45              


Val Ser Ala Glu Ser Ala Leu Glu Ser Asp Leu Lys Val Glu Met Met 
    50                  55                  60                  


Ala Gly Gly Thr Gln Ile Thr Pro Leu Asn Asp Asn Val Thr Ile Phe 
65                  70                  75                  80  


Cys Asn Ile Phe Tyr Ser Gln Pro Leu Asn Ile Thr Ser Met Gly Ile 
                85                  90                  95      


Thr Trp Phe Trp Lys Ser Leu Thr Phe Asp Lys Glu Val Lys Val Phe 
            100                 105                 110         


Glu Phe Phe Gly Asp His Gln Glu Ala Phe Arg Pro Gly Ala Ile Val 
        115                 120                 125             


Ser Pro Trp Arg Leu Lys Ser Gly Asp Ala Ser Leu Arg Leu Pro Gly 
    130                 135                 140                 


Ile Gln Leu Glu Glu Ala Gly Glu Tyr Arg Cys Glu Val Val Val Thr 
145                 150                 155                 160 


Pro Leu Lys Ala Gln Gly Thr Val Gln Leu Glu Val Val Ala Ser Pro 
                165                 170                 175     


Ala Ser Arg Leu Leu Leu Asp Gln Val Gly Met Lys Glu Asn Glu Asp 
            180                 185                 190         


Lys Tyr Met Cys Glu Ser Ser Gly Phe Tyr Pro Glu Ala Ile Asn Ile 
        195                 200                 205             


Thr Trp Glu Lys Gln Thr Gln Lys Phe Pro His Pro Ile Glu Ile Ser 
    210                 215                 220                 


Glu Asp Val Ile Thr Gly Pro Thr Ile Lys Asn Met Asp Gly Thr Phe 
225                 230                 235                 240 


Asn Val Thr Ser Cys Leu Lys Leu Asn Ser Ser Gln Glu Asp Pro Gly 
                245                 250                 255     


Thr Val Tyr Gln Cys Val Val Arg His Ala Ser Leu His Thr Pro Leu 
            260                 265                 270         


Arg Ser Asn Phe Thr Leu Thr Ala Ala Arg His Ser Leu Ser Glu Thr 
        275                 280                 285             


Glu Lys Thr Asp Asn Phe Ser Ile His Trp Trp Pro Asp Ile Thr His 
    290                 295                 300                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val 
305                 310                 315                 320 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                325                 330                 335     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            340                 345                 350         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        355                 360                 365             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    370                 375                 380                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
385                 390                 395                 400 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                405                 410                 415     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            420                 425                 430         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Gln Pro Glu 
        435                 440                 445             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    450                 455                 460                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
465                 470                 475                 480 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                485                 490                 495     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His Met Gly Gly Asp 
            500                 505                 510         


Glu Lys Thr Thr Gly Trp Arg Gly Gly His Val Val Glu Gly Leu Ala 
        515                 520                 525             


Gly Glu Leu Glu Gln Leu Arg Ala Arg Leu Glu His His Pro Gln Gly 
    530                 535                 540                 


Gln Arg Glu Pro 
545             


<210>  3
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the heavy chain of anti-B7-H6 clone 1.18 
       (IGHV/IGHD/IGHJ)

<400>  3

Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Asn Asn Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Tyr Gly Tyr Asp Pro Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  4
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of the heavy chain of anti-B7-H6 clone 1.18
       (IGHV/IGHD/IGHJ), FR1

<400>  4
gacgtgaagc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctct                                                        75


<210>  5
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of the heavy chain of anti-B7-H6 clone 1.18
       (IGHV/IGHD/IGHJ), CDR1

<400>  5
ggattcactt tcagtagcta tacc                                              24


<210>  6
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of the heavy chain of anti-B7-H6 clone 1.18
       (IGHV/IGHD/IGHJ), FR2

<400>  6
atgtcttggg ttcgccagac tccggagaag aggctggagt gggtcgcaac c                51


<210>  7
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of the heavy chain of anti-B7-H6 clone 1.18
       (IGHV/IGHD/IGHJ), CDR2

<400>  7
attaataatg gtggtagtta cacc                                              24


<210>  8
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of the heavy chain of anti-B7-H6 clone 1.18
       (IGHV/IGHD/IGHJ), FR3

<400>  8
tactatccag acagtgtgaa gggccgattc accatctcca gagacaatgc caagaacacc       60

ctgtacctgc aaatgagcag tctgaagtct gaggacacag ccatttatta ctgc            114


<210>  9
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of the heavy chain of anti-B7-H6 clone 1.18
       (IGHV/IGHD/IGHJ), CDR3

<400>  9
tatggttacg acccggcctg gtttgcttac                                        30


<210>  10
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of the heavy chain of anti-B7-H6 clone 1.18
       (IGHV/IGHD/IGHJ), FR4

<400>  10
tggggccaag ggactctggt cactgtctct gca                                    33


<210>  11
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the heavy chain of anti-B7-H6 clone 1.18 
       (IGHV/IGHD/IGHJ/IGHG1), secreted form

<400>  11

Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Asn Asn Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Tyr Gly Tyr Asp Pro Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu 
        115                 120                 125             


Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser 
145                 150                 155                 160 


Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Glu Ser 
                165                 170                 175     


Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Pro Arg 
            180                 185                 190         


Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Ile Val Pro Glu Val Ser Ser Val Phe Ile Phe 
    210                 215                 220                 


Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val 
225                 230                 235                 240 


Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe 
                245                 250                 255     


Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro 
            260                 265                 270         


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro 
        275                 280                 285             


Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val 
    290                 295                 300                 


Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
305                 310                 315                 320 


Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys 
                325                 330                 335     


Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp 
            340                 345                 350         


Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro 
        355                 360                 365             


Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asn Thr Asn Gly Ser 
    370                 375                 380                 


Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala 
385                 390                 395                 400 


Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His 
                405                 410                 415     


His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
            420                 425             


<210>  12
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the heavy chain of anti-B7-H6 clone 1.18 
       (IGHV/IGHD/IGHJ/IGHG1), membrane bound form

<400>  12

Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Asn Asn Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Tyr Gly Tyr Asp Pro Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu 
        115                 120                 125             


Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser 
145                 150                 155                 160 


Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Glu Ser 
                165                 170                 175     


Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Pro Arg 
            180                 185                 190         


Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Ile Val Pro Glu Val Ser Ser Val Phe Ile Phe 
    210                 215                 220                 


Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val 
225                 230                 235                 240 


Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe 
                245                 250                 255     


Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro 
            260                 265                 270         


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro 
        275                 280                 285             


Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val 
    290                 295                 300                 


Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
305                 310                 315                 320 


Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys 
                325                 330                 335     


Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp 
            340                 345                 350         


Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro 
        355                 360                 365             


Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asn Thr Asn Gly Ser 
    370                 375                 380                 


Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala 
385                 390                 395                 400 


Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His 
                405                 410                 415     


His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys Leu Gln Leu Asp 
            420                 425                 430         


Glu Thr Cys Ala Glu Ala Gln Asp Gly Glu Leu Asp Gly Leu Trp Thr 
        435                 440                 445             


Thr Ile Thr Ile Phe Ile Ser Leu Phe Leu Leu Ser Val Cys Tyr Ser 
    450                 455                 460                 


Ala Ala Val Thr Leu Phe Lys Val Lys Trp Ile Phe Ser Ser Val Val 
465                 470                 475                 480 


Glu Leu Lys Gln Thr Leu Val Pro Glu Tyr Lys Asn Met Ile Gly Gln 
                485                 490                 495     


Ala Pro 
        


<210>  13
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the light chain of anti-B7-H6 clone 1.18 
       (IGLV/IGLJ)

<400>  13

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  14
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of the light chain of anti-B7-H6 clone 1.18
       (IGLV/IGLJ), FR1

<400>  14

Cys Ala Gly Gly Cys Thr Gly Thr Thr Gly Thr Gly Ala Cys Thr Cys 
1               5                   10                  15      


Ala Gly Gly Ala Ala Thr Cys Thr Gly Cys Ala Cys Thr Cys Ala Cys 
            20                  25                  30          


Cys Ala Cys Ala Thr Cys Ala Cys Cys Thr Gly Gly Thr Gly Ala Ala 
        35                  40                  45              


Ala Cys Ala Gly Thr Cys Ala Cys Ala Cys Thr Cys Ala Cys Thr Thr 
    50                  55                  60                  


Gly Thr Cys Gly Cys Thr Cys Ala Ala Gly Thr 
65                  70                  75  


<210>  15
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of the light chain of anti-B7-H6 clone 1.18
       (IGLV/IGLJ), CDR1

<400>  15
actggggctg ttacaactag taactat                                           27


<210>  16
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of the light chain of anti-B7-H6 clone 1.18
       (IGLV/IGLJ), FR2

<400>  16
gccaactggg tccaagaaaa accagatcat ttattcactg gtctaatagg t                51


<210>  17
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of the light chain of anti-B7-H6 clone 1.18
       (IGLV/IGLJ), CDR2

<400>  17
ggtaccaac                                                                9


<210>  18
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of the light chain of anti-B7-H6 clone 1.18
       (IGLV/IGLJ), FR3

<400>  18
aaccgagctc caggtgttcc tgccagattc tcaggctccc tgattggaga caaggctgcc       60

ctcaccatca caggggcaca gactgaggat gaggcaatat atttctgt                   108


<210>  19
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of the light chain of anti-B7-H6 clone 1.18
       (IGLV/IGLJ), CDR3

<400>  19
gctctatggt acagcaacca ctgggtg                                           27


<210>  20
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of the light chain of anti-B7-H6 clone 1.18
       (IGLV/IGLJ), FR4

<400>  20
ttcggtggag gaaccaaact gactgtcctg                                        30


<210>  21
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the light chain of anti-B7-H6 clone 1.18 
       (IGLV/IGLJ/IGLC)

<400>  21

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val Thr Gln 
145                 150                 155                 160 


Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys Tyr Met 
                165                 170                 175     


Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg His Ser 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val Glu Lys Ser 
        195                 200                 205             


Leu Ser Arg Ala Asp Cys Ser 
    210                 215 


<210>  22
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  22

Gly Asp His Gln Glu Ala Phe Arg Pro Gly Ala Ile Val Ser Pro Trp 
1               5                   10                  15      


Arg Leu Lys Ser Gly Asp Ala Ser Leu Arg Leu Pro Gly Ile Gln Leu 
            20                  25                  30          


Glu Glu Ala Gly Glu Tyr Arg Cys Glu Val Val Val Thr Pro Leu Lys 
        35                  40                  45              


Ala Gln Gly Thr Val Gln Leu Glu Val Val 
    50                  55              


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for B7-H6

<400>  23
gacctggagc cattgtgtct                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for B7-H6

<400>  24
aagctggact gttccctgtg                                                   20


<210>  25
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for GADPH

<400>  25
gcaaattcca tggcaccgt                                                    19


<210>  26
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for GADPH

<400>  26
tcgccccact tgattttgg                                                    19


