                         SEQUENCE LISTING

<110>  DuPont
       John, O'Brien P
       Mark, Payne S
 
<120>  High titer production of highly linear poly (a 1, 3 glucan)

<130>  CL5383

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  4434
<212>  DNA
<213>  artificial sequence

<220>
<223>  codon-optimized gtfj gene from Streptococcus salivarius

<400>  1
atggacgaaa cgcaggataa gaccgtgacg cagagcaaca gcggcaccac cgcttccctg       60

gtcactagcc ctgaagccac gaaagaggcg gacaaacgca cgaacactaa agaggccgac      120

gttctgacgc ctgcaaaaga aacgaacgca gtcgagactg cgaccaccac taacacccag      180

gcgacggcgg aggccgccac gaccgcgacc accgcggacg tcgcggtggc tgcggtgccg      240

aacaaagaag cggtcgttac cacggatgct ccggcggtca cgaccgagaa agcggaagaa      300

cagccggcta ccgttaaagc agaagtcgtc aatacggaag tgaaagcgcc ggaagcggct      360

ctgaaagaca gcgaggttga ggcagcgctg agcctgaaga acatcaagaa cattgatggc      420

aagtattact atgttaatga ggatggcagc cacaaagaga atttcgctat taccgtgaat      480

ggccagctgc tgtactttgg taaagacggt gcgctgacgt cctctagcac gtattctttt      540

accccaggca ctaccaatat cgtggacggt tttagcatta acaaccgcgc ttacgacagc      600

agcgaggcga gctttgagct gatcgacggt tacttgaccg cagacagctg gtatcgtccg      660

gctagcatca tcaaagatgg tgttacgtgg caagcgtcca ccgccgagga ttttcgtccg      720

ctgctgatgg catggtggcc gaatgtggat acgcaggtga actatttgaa ttacatgtcc      780

aaagttttca acctggacgc gaaatactct agcaccgaca aacaggaaac cctgaaagtg      840

gcagcaaaag acattcaaat caagattgaa caaaagattc aagcggagaa gagcacgcag      900

tggctgcgtg aaactatcag cgcctttgtg aaaacccagc cgcagtggaa caaagaaacc      960

gagaattaca gcaagggtgg tggtgaggac cacctgcaag gtggcgcact gctgtatgtt     1020

aacgacagcc gtaccccttg ggcgaatagc gattaccgtc gtctgaatcg caccgcaacc     1080

aatcagacgg gcacgatcga taagtctatt ctggacgagc agtctgaccc aaaccacatg     1140

ggcggtttcg actttctgct ggcgaacgac gtcgacctga gcaatccggt cgtgcaggct     1200

gagcagctga atcaaatcca ctatctgatg aattggggtt ccattgtgat gggtgacaag     1260

gatgcgaact ttgacggcat tcgtgtcgat gcagttgaca acgtggacgc ggacatgttg     1320

caactgtata ccaattactt ccgtgagtac tacggtgtga acaagagcga agctaacgca     1380

ctggctcaca tcagcgttct ggaggcgtgg agcctgaatg ataatcatta caatgacaag     1440

accgatggtg cggcactggc aatggagaat aagcaacgtc tggcgctgtt gttttcgttg     1500

gcgaaaccga tcaaagagcg taccccggca gtgagcccgc tgtataacaa caccttcaat     1560

accacccagc gtgatgaaaa gaccgattgg attaacaaag acggtagcaa ggcttacaac     1620

gaagatggca cggtcaaaca atcgaccatc ggtaagtaca acgagaaata cggtgacgca     1680

tccggtaact acgttttcat ccgtgcccac gataacaacg tccaggacat catcgccgag     1740

atcatcaaga aagagatcaa cccgaaaagc gacggcttca ccatcaccga cgccgaaatg     1800

aagcaagcct ttgaaatcta taacaaagat atgctgtcga gcgacaaaaa gtataccctg     1860

aataacattc cggcagcgta tgccgtgatg ttgcagaata tggaaacgat tacccgcgtc     1920

tattacggtg atctgtatac ggacgacggt cactacatgg aaaccaaatc tccgtattac     1980

gataccatcg tgaatttgat gaagagccgt atcaagtatg tttcgggtgg ccaggcgcaa     2040

cgtagctatt ggctgccgac cgacggtaag atggacaata gcgacgttga gctgtaccgc     2100

acgaatgagg tttacacgag cgtgcgctat ggtaaggata tcatgaccgc taatgatacc     2160

gaaggctcta agtattcccg caccagcggc caagtcacct tggtcgcgaa caatccgaag     2220

ctgaatctgg accaaagcgc caagttgaat gtggagatgg gcaaaatcca tgcgaatcag     2280

aagtatcgcg cactgattgt cggcactgcg gacggcatta agaactttac ttccgacgcg     2340

gacgccattg cagcgggtta tgtgaaagaa accgatagca acggcgtgct gaccttcggt     2400

gctaacgaca ttaagggcta cgaaacgttt gatatgagcg gtttcgtggc ggtgtgggtt     2460

ccggtgggtg catctgacaa tcaggacatt cgtgttgcgc cgagcaccga ggcaaagaaa     2520

gaaggtgagc tgaccttgaa ggcgacggaa gcgtatgata gccagctgat ttacgaaggc     2580

tttagcaatt tccagacgat cccagatggc agcgatccgt ccgtgtatac gaaccgcaag     2640

attgcggaga acgtggatct gttcaaaagc tggggtgtca ccagctttga gatggcaccg     2700

caatttgtct cggcggatga tggcaccttt ctggatagcg ttattcagaa tggctacgcc     2760

ttcgccgacc gttatgacct ggccatgtcc aagaacaaca agtatggtag caaagaggac     2820

ctgcgtgatg cactgaaagc actgcataag gcgggtattc aagctatcgc agactgggtt     2880

ccagaccaga tctaccagct gccgggcaaa gaagttgtca ccgccacccg tacggatggt     2940

gctggccgta agatcgcaga cgcgattatc gaccattctc tgtatgttgc aaacagcaaa     3000

agcagcggca aagattatca agcaaagtac ggtggcgagt tcctggccga gctgaaagcc     3060

aaatacccgg aaatgttcaa agttaacatg attagcacgg gtaagccgat tgatgactcc     3120

gtgaaattga agcaatggaa agccgagtac ttcaatggca ccaacgtttt ggaacgtggt     3180

gtcggctatg ttctgagcga cgaggcgacc ggtaagtatt tcacggtgac caaagaaggc     3240

aatttcattc cgctgcaact gacgggtaaa gagaaagtta tcacgggttt ctccagcgat     3300

ggtaagggta tcacctattt cggtacgagc ggtacgcagg cgaagtctgc gtttgttacc     3360

ttcaatggta acacctacta tttcgacgcg cgtggccaca tggttaccaa tagcgaatac     3420

agcccgaatg gcaaggacgt ctaccgtttt ctgccgaacg gtatcatgct gagcaatgcg     3480

ttttacattg atgcgaacgg taatacctac ctgtacaact ctaagggtca aatgtacaaa     3540

ggcggttaca cgaaattcga tgtttctgaa acggataagg acggtaaaga gtccaaggtc     3600

gtcaagttcc gctactttac gaacgaaggc gtcatggcca agggtgttac cgtcattgat     3660

ggttttaccc aatacttcgg tgaggacggc tttcaagcga aggataagct ggtcaccttc     3720

aagggcaaga cgtattactt cgacgcacac actggtaatg gtatcaaaga tacctggcgc     3780

aatatcaatg gtaaatggta ctatttcgac gcgaatggcg ttgctgcgac cggtgcgcag     3840

gtgattaacg gccagaaact gtacttcaac gaggatggct cccaagtcaa aggcggcgtg     3900

gttaagaacg cagacggcac ctatagcaaa tacaaagaag gttttggtga gctggttact     3960

aacgagtttt tcacgactga tggcaatgtt tggtactacg ccggtgcaaa tggtaaaacc     4020

gttaccggtg cacaagtgat caacggccaa catttgtact tcaatgcgga cggttcccag     4080

gtgaagggtg gcgttgtcaa gaacgcggat ggcacctaca gcaagtacaa tgctagcact     4140

ggtgaacgtc tgacgaacga gttctttacg accggtgata acaattggta ttacattggc     4200

gcaaacggta agagcgtgac gggtgaggtc aagattggtg atgatactta ctttttcgcg     4260

aaggatggca aacaagttaa aggtcaaacc gtcagcgccg gtaatggtcg cattagctac     4320

tactacggtg acagcggcaa gcgtgcggtt agcacctgga ttgagattca gccgggtgtt     4380

tatgtgtatt tcgacaaaaa cggtttggcg taccctccgc gtgttctgaa ttaa           4434


<210>  2
<211>  8455
<212>  DNA
<213>  artificial sequence

<220>
<223>  plasmid pMP52

<400>  2
ctcatgacca aaatccctta acgtgagtta cgcgcgcgtc gttccactga gcgtcagacc       60

ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct      120

tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa      180

ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact gttcttctag      240

tgtagccgta gttagcccac cacttcaaga actctgtagc accgcctaca tacctcgctc      300

tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg      360

actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca      420

cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat      480

gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg      540

tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc      600

ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc      660

ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc      720

cttttgctca catgttcttt cctgcgttat cccctgattc tgtggataac cgtattaccg      780

cctttgagtg agctgatacc gctcgccgca gccgaacgac cgagcgcagc gagtcagtga      840

gcgaggaagc ggaaggcgag agtagggaac tgccaggcat caaactaagc agaaggcccc      900

tgacggatgg cctttttgcg tttctacaaa ctctttctgt gttgtaaaac gacggccagt      960

cttaagctcg ggccccctgg gcggttctga taacgagtaa tcgttaatcc gcaaataacg     1020

taaaaacccg cttcggcggg tttttttatg gggggagttt agggaaagag catttgtcag     1080

aatatttaag ggcgcctgtc actttgcttg atatatgaga attatttaac cttataaatg     1140

agaaaaaagc aacgcacttt aaataagata cgttgctttt tcgattgatg aacacctata     1200

attaaactat tcatctatta tttatgattt tttgtatata caatatttct agtttgttaa     1260

agagaattaa gaaaataaat ctcgaaaata ataaagggaa aatcagtttt tgatatcaaa     1320

attatacatg tcaacgataa tacaaaatat aatacaaact ataagatgtt atcagtattt     1380

attatgcatt tagaataaat tttgtgtcgc ccttaattgt gagcggataa caattacgag     1440

cttcatgcac agtgaaatca tgaaaaattt atttgctttg tgagcggata acaattataa     1500

tatgtggaat tgtgagcgct cacaattcca caacggtttc cctctagaaa taattttgtt     1560

taacttttga attctctaga ggaaggtaaa acatatggac gaaacgcagg ataagaccgt     1620

gacgcagagc aacagcggca ccaccgcttc cctggtcact agccctgaag ccacgaaaga     1680

ggcggacaaa cgcacgaaca ctaaagaggc cgacgttctg acgcctgcaa aagaaacgaa     1740

cgcagtcgag actgcgacca ccactaacac ccaggcgacg gcggaggccg ccacgaccgc     1800

gaccaccgcg gacgtcgcgg tggctgcggt gccgaacaaa gaagcggtcg ttaccacgga     1860

tgctccggcg gtcacgaccg agaaagcgga agaacagccg gctaccgtta aagcagaagt     1920

cgtcaatacg gaagtgaaag cgccggaagc ggctctgaaa gacagcgagg ttgaggcagc     1980

gctgagcctg aagaacatca agaacattga tggcaagtat tactatgtta atgaggatgg     2040

cagccacaaa gagaatttcg ctattaccgt gaatggccag ctgctgtact ttggtaaaga     2100

cggtgcgctg acgtcctcta gcacgtattc ttttacccca ggcactacca atatcgtgga     2160

cggttttagc attaacaacc gcgcttacga cagcagcgag gcgagctttg agctgatcga     2220

cggttacttg accgcagaca gctggtatcg tccggctagc atcatcaaag atggtgttac     2280

gtggcaagcg tccaccgccg aggattttcg tccgctgctg atggcatggt ggccgaatgt     2340

ggatacgcag gtgaactatt tgaattacat gtccaaagtt ttcaacctgg acgcgaaata     2400

ctctagcacc gacaaacagg aaaccctgaa agtggcagca aaagacattc aaatcaagat     2460

tgaacaaaag attcaagcgg agaagagcac gcagtggctg cgtgaaacta tcagcgcctt     2520

tgtgaaaacc cagccgcagt ggaacaaaga aaccgagaat tacagcaagg gtggtggtga     2580

ggaccacctg caaggtggcg cactgctgta tgttaacgac agccgtaccc cttgggcgaa     2640

tagcgattac cgtcgtctga atcgcaccgc aaccaatcag acgggcacga tcgataagtc     2700

tattctggac gagcagtctg acccaaacca catgggcggt ttcgactttc tgctggcgaa     2760

cgacgtcgac ctgagcaatc cggtcgtgca ggctgagcag ctgaatcaaa tccactatct     2820

gatgaattgg ggttccattg tgatgggtga caaggatgcg aactttgacg gcattcgtgt     2880

cgatgcagtt gacaacgtgg acgcggacat gttgcaactg tataccaatt acttccgtga     2940

gtactacggt gtgaacaaga gcgaagctaa cgcactggct cacatcagcg ttctggaggc     3000

gtggagcctg aatgataatc attacaatga caagaccgat ggtgcggcac tggcaatgga     3060

gaataagcaa cgtctggcgc tgttgttttc gttggcgaaa ccgatcaaag agcgtacccc     3120

ggcagtgagc ccgctgtata acaacacctt caataccacc cagcgtgatg aaaagaccga     3180

ttggattaac aaagacggta gcaaggctta caacgaagat ggcacggtca aacaatcgac     3240

catcggtaag tacaacgaga aatacggtga cgcatccggt aactacgttt tcatccgtgc     3300

ccacgataac aacgtccagg acatcatcgc cgagatcatc aagaaagaga tcaacccgaa     3360

aagcgacggc ttcaccatca ccgacgccga aatgaagcaa gcctttgaaa tctataacaa     3420

agatatgctg tcgagcgaca aaaagtatac cctgaataac attccggcag cgtatgccgt     3480

gatgttgcag aatatggaaa cgattacccg cgtctattac ggtgatctgt atacggacga     3540

cggtcactac atggaaacca aatctccgta ttacgatacc atcgtgaatt tgatgaagag     3600

ccgtatcaag tatgtttcgg gtggccaggc gcaacgtagc tattggctgc cgaccgacgg     3660

taagatggac aatagcgacg ttgagctgta ccgcacgaat gaggtttaca cgagcgtgcg     3720

ctatggtaag gatatcatga ccgctaatga taccgaaggc tctaagtatt cccgcaccag     3780

cggccaagtc accttggtcg cgaacaatcc gaagctgaat ctggaccaaa gcgccaagtt     3840

gaatgtggag atgggcaaaa tccatgcgaa tcagaagtat cgcgcactga ttgtcggcac     3900

tgcggacggc attaagaact ttacttccga cgcggacgcc attgcagcgg gttatgtgaa     3960

agaaaccgat agcaacggcg tgctgacctt cggtgctaac gacattaagg gctacgaaac     4020

gtttgatatg agcggtttcg tggcggtgtg ggttccggtg ggtgcatctg acaatcagga     4080

cattcgtgtt gcgccgagca ccgaggcaaa gaaagaaggt gagctgacct tgaaggcgac     4140

ggaagcgtat gatagccagc tgatttacga aggctttagc aatttccaga cgatcccaga     4200

tggcagcgat ccgtccgtgt atacgaaccg caagattgcg gagaacgtgg atctgttcaa     4260

aagctggggt gtcaccagct ttgagatggc accgcaattt gtctcggcgg atgatggcac     4320

ctttctggat agcgttattc agaatggcta cgccttcgcc gaccgttatg acctggccat     4380

gtccaagaac aacaagtatg gtagcaaaga ggacctgcgt gatgcactga aagcactgca     4440

taaggcgggt attcaagcta tcgcagactg ggttccagac cagatctacc agctgccggg     4500

caaagaagtt gtcaccgcca cccgtacgga tggtgctggc cgtaagatcg cagacgcgat     4560

tatcgaccat tctctgtatg ttgcaaacag caaaagcagc ggcaaagatt atcaagcaaa     4620

gtacggtggc gagttcctgg ccgagctgaa agccaaatac ccggaaatgt tcaaagttaa     4680

catgattagc acgggtaagc cgattgatga ctccgtgaaa ttgaagcaat ggaaagccga     4740

gtacttcaat ggcaccaacg ttttggaacg tggtgtcggc tatgttctga gcgacgaggc     4800

gaccggtaag tatttcacgg tgaccaaaga aggcaatttc attccgctgc aactgacggg     4860

taaagagaaa gttatcacgg gtttctccag cgatggtaag ggtatcacct atttcggtac     4920

gagcggtacg caggcgaagt ctgcgtttgt taccttcaat ggtaacacct actatttcga     4980

cgcgcgtggc cacatggtta ccaatagcga atacagcccg aatggcaagg acgtctaccg     5040

ttttctgccg aacggtatca tgctgagcaa tgcgttttac attgatgcga acggtaatac     5100

ctacctgtac aactctaagg gtcaaatgta caaaggcggt tacacgaaat tcgatgtttc     5160

tgaaacggat aaggacggta aagagtccaa ggtcgtcaag ttccgctact ttacgaacga     5220

aggcgtcatg gccaagggtg ttaccgtcat tgatggtttt acccaatact tcggtgagga     5280

cggctttcaa gcgaaggata agctggtcac cttcaagggc aagacgtatt acttcgacgc     5340

acacactggt aatggtatca aagatacctg gcgcaatatc aatggtaaat ggtactattt     5400

cgacgcgaat ggcgttgctg cgaccggtgc gcaggtgatt aacggccaga aactgtactt     5460

caacgaggat ggctcccaag tcaaaggcgg cgtggttaag aacgcagacg gcacctatag     5520

caaatacaaa gaaggttttg gtgagctggt tactaacgag tttttcacga ctgatggcaa     5580

tgtttggtac tacgccggtg caaatggtaa aaccgttacc ggtgcacaag tgatcaacgg     5640

ccaacatttg tacttcaatg cggacggttc ccaggtgaag ggtggcgttg tcaagaacgc     5700

ggatggcacc tacagcaagt acaatgctag cactggtgaa cgtctgacga acgagttctt     5760

tacgaccggt gataacaatt ggtattacat tggcgcaaac ggtaagagcg tgacgggtga     5820

ggtcaagatt ggtgatgata cttacttttt cgcgaaggat ggcaaacaag ttaaaggtca     5880

aaccgtcagc gccggtaatg gtcgcattag ctactactac ggtgacagcg gcaagcgtgc     5940

ggttagcacc tggattgaga ttcagccggg tgtttatgtg tatttcgaca aaaacggttt     6000

ggcgtaccct ccgcgtgttc tgaattaatg agtctagact gcagggtacc aagcttcccc     6060

aagggcgaca ccccataatt agcccgggcg aaaggcccag tctttcgact gagcctttcg     6120

ttttatttga tgcctggcag ttccctactc tcgcatgggg agtccccaca ctaccatcgg     6180

cgctacggcg tttcacttct gagttcggca tggggtcagg tgggaccacc gcgctactgc     6240

cgccaggcaa acaaggggtg ttatgagcca tattcaggta taaatgggct cgcgataatg     6300

ttcagaattg gttaattggt tgtaacactg acccctattt gtttattttt ctaaatacat     6360

tcaaatatgt atccgctcat gagacaataa ccctgataaa tgcttcaata atattgaaaa     6420

aggaagaata tgagtattca acatttccgt gtcgccctta ttcccttttt tgcggcattt     6480

tgccttcctg tttttgctca cccagaaacg ctggtgaaag taaaagatgc tgaagatcag     6540

ttgggtgcac gagtgggtta catcgaactg gatctcaaca gcggtaagat ccttgagagt     6600

tttcgccccg aagaacgttt tccaatgatg agcactttta aagttctgct atgtggcgcg     6660

gtattatccc gtattgacgc cgggcaagag caactcggtc gccgcataca ctattctcag     6720

aatgacttgg ttgagtactc accagtcaca gaaaagcatc ttacggatgg catgacagta     6780

agagaattat gcagtgctgc cataaccatg agtgataaca ctgcggccaa cttacttctg     6840

acaacgatcg gaggaccgaa ggagctaacc gcttttttgc acaacatggg ggatcatgta     6900

actcgccttg atcgttggga accggagctg aatgaagcca taccaaacga cgagcgtgac     6960

accacgatgc ctgtagcgat ggcaacaacg ttgcgcaaac tattaactgg cgaactactt     7020

actctagctt cccggcaaca attaatagac tggatggagg cggataaagt tgcaggacca     7080

cttctgcgct cggcccttcc ggctggctgg tttattgctg ataaatccgg agccggtgag     7140

cgtggttctc gcggtatcat cgcagcgctg gggccagatg gtaagccctc ccgtatcgta     7200

gttatctaca cgacggggag tcaggcaact atggatgaac gaaatagaca gatcgctgag     7260

ataggtgcct cactgattaa gcattggtaa gcggcgcgcc atcgaatggc gcaaaacctt     7320

tcgcggtatg gcatgatagc gcccggaaga gagtcaattc agggtggtga atatgaaacc     7380

agtaacgtta tacgatgtcg cagagtatgc cggtgtctct tatcagaccg tttcccgcgt     7440

ggtgaaccag gccagccacg tttctgcgaa aacgcgggaa aaagtggaag cggcgatggc     7500

ggagctgaat tacattccca accgcgtggc acaacaactg gcgggcaaac agtcgttgct     7560

gattggcgtt gccacctcca gtctggccct gcacgcgccg tcgcaaattg tcgcggcgat     7620

taaatctcgc gccgatcaac tgggtgccag cgtggtggtg tcgatggtag aacgaagcgg     7680

cgtcgaagcc tgtaaagcgg cggtgcacaa tcttctcgcg caacgcgtca gtgggctgat     7740

cattaactat ccgctggatg accaggatgc cattgctgtg gaagctgcct gcactaatgt     7800

tccggcgtta tttcttgatg tctctgacca gacacccatc aacagtatta ttttctccca     7860

tgaggacggt acgcgactgg gcgtggagca tctggtcgca ttgggtcacc agcaaatcgc     7920

gctgttagcg ggcccattaa gttctgtctc ggcgcgtctg cgtctggctg gctggcataa     7980

atatctcact cgcaatcaaa ttcagccgat agcggaacgg gaaggcgact ggagtgccat     8040

gtccggtttt caacaaacca tgcaaatgct gaatgagggc atcgttccca ctgcgatgct     8100

ggttgccaac gatcagatgg cgctgggcgc aatgcgcgcc attaccgagt ccgggctgcg     8160

cgttggtgcg gatatctcgg tagtgggata cgacgatacc gaagatagct catgttatat     8220

cccgccgtta accaccatca aacaggattt tcgcctgctg gggcaaacca gcgtggaccg     8280

cttgctgcaa ctctctcagg gccaggcggt gaagggcaat cagctgttgc cagtctcact     8340

ggtgaaaaga aaaaccaccc tggcgcccaa tacgcaaacc gcctctcccc gcgcgttggc     8400

cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtga          8455


<210>  3
<211>  1518
<212>  PRT
<213>  Streptococcus salivarius

<400>  3

Met Glu Asn Lys Ile His Tyr Lys Leu His Lys Val Lys Lys Gln Trp 
1               5                   10                  15      


Val Thr Ile Ala Val Ala Ser Val Ala Leu Ala Thr Val Leu Gly Gly 
            20                  25                  30          


Leu Ser Val Thr Thr Ser Ser Val Ser Ala Asp Glu Thr Gln Asp Lys 
        35                  40                  45              


Thr Val Thr Gln Ser Asn Ser Gly Thr Thr Ala Ser Leu Val Thr Ser 
    50                  55                  60                  


Pro Glu Ala Thr Lys Glu Ala Asp Lys Arg Thr Asn Thr Lys Glu Ala 
65                  70                  75                  80  


Asp Val Leu Thr Pro Ala Lys Glu Thr Asn Ala Val Glu Thr Ala Thr 
                85                  90                  95      


Thr Thr Asn Thr Gln Ala Thr Ala Glu Ala Ala Thr Thr Ala Thr Thr 
            100                 105                 110         


Ala Asp Val Ala Val Ala Ala Val Pro Asn Lys Glu Ala Val Val Thr 
        115                 120                 125             


Thr Asp Ala Pro Ala Val Thr Thr Glu Lys Ala Glu Glu Gln Pro Ala 
    130                 135                 140                 


Thr Val Lys Ala Glu Val Val Asn Thr Glu Val Lys Ala Pro Glu Ala 
145                 150                 155                 160 


Ala Leu Lys Asp Ser Glu Val Glu Ala Ala Leu Ser Leu Lys Asn Ile 
                165                 170                 175     


Lys Asn Ile Asp Gly Lys Tyr Tyr Tyr Val Asn Glu Asp Gly Ser His 
            180                 185                 190         


Lys Glu Asn Phe Ala Ile Thr Val Asn Gly Gln Leu Leu Tyr Phe Gly 
        195                 200                 205             


Lys Asp Gly Ala Leu Thr Ser Ser Ser Thr Tyr Ser Phe Thr Pro Gly 
    210                 215                 220                 


Thr Thr Asn Ile Val Asp Gly Phe Ser Ile Asn Asn Arg Ala Tyr Asp 
225                 230                 235                 240 


Ser Ser Glu Ala Ser Phe Glu Leu Ile Asp Gly Tyr Leu Thr Ala Asp 
                245                 250                 255     


Ser Trp Tyr Arg Pro Ala Ser Ile Ile Lys Asp Gly Val Thr Trp Gln 
            260                 265                 270         


Ala Ser Thr Ala Glu Asp Phe Arg Pro Leu Leu Met Ala Trp Trp Pro 
        275                 280                 285             


Asn Val Asp Thr Gln Val Asn Tyr Leu Asn Tyr Met Ser Lys Val Phe 
    290                 295                 300                 


Asn Leu Asp Ala Lys Tyr Ser Ser Thr Asp Lys Gln Glu Thr Leu Lys 
305                 310                 315                 320 


Val Ala Ala Lys Asp Ile Gln Ile Lys Ile Glu Gln Lys Ile Gln Ala 
                325                 330                 335     


Glu Lys Ser Thr Gln Trp Leu Arg Glu Thr Ile Ser Ala Phe Val Lys 
            340                 345                 350         


Thr Gln Pro Gln Trp Asn Lys Glu Thr Glu Asn Tyr Ser Lys Gly Gly 
        355                 360                 365             


Gly Glu Asp His Leu Gln Gly Gly Ala Leu Leu Tyr Val Asn Asp Ser 
    370                 375                 380                 


Arg Thr Pro Trp Ala Asn Ser Asp Tyr Arg Arg Leu Asn Arg Thr Ala 
385                 390                 395                 400 


Thr Asn Gln Thr Gly Thr Ile Asp Lys Ser Ile Leu Asp Glu Gln Ser 
                405                 410                 415     


Asp Pro Asn His Met Gly Gly Phe Asp Phe Leu Leu Ala Asn Asp Val 
            420                 425                 430         


Asp Leu Ser Asn Pro Val Val Gln Ala Glu Gln Leu Asn Gln Ile His 
        435                 440                 445             


Tyr Leu Met Asn Trp Gly Ser Ile Val Met Gly Asp Lys Asp Ala Asn 
    450                 455                 460                 


Phe Asp Gly Ile Arg Val Asp Ala Val Asp Asn Val Asp Ala Asp Met 
465                 470                 475                 480 


Leu Gln Leu Tyr Thr Asn Tyr Phe Arg Glu Tyr Tyr Gly Val Asn Lys 
                485                 490                 495     


Ser Glu Ala Asn Ala Leu Ala His Ile Ser Val Leu Glu Ala Trp Ser 
            500                 505                 510         


Leu Asn Asp Asn His Tyr Asn Asp Lys Thr Asp Gly Ala Ala Leu Ala 
        515                 520                 525             


Met Glu Asn Lys Gln Arg Leu Ala Leu Leu Phe Ser Leu Ala Lys Pro 
    530                 535                 540                 


Ile Lys Glu Arg Thr Pro Ala Val Ser Pro Leu Tyr Asn Asn Thr Phe 
545                 550                 555                 560 


Asn Thr Thr Gln Arg Asp Glu Lys Thr Asp Trp Ile Asn Lys Asp Gly 
                565                 570                 575     


Ser Lys Ala Tyr Asn Glu Asp Gly Thr Val Lys Gln Ser Thr Ile Gly 
            580                 585                 590         


Lys Tyr Asn Glu Lys Tyr Gly Asp Ala Ser Gly Asn Tyr Val Phe Ile 
        595                 600                 605             


Arg Ala His Asp Asn Asn Val Gln Asp Ile Ile Ala Glu Ile Ile Lys 
    610                 615                 620                 


Lys Glu Ile Asn Pro Lys Ser Asp Gly Phe Thr Ile Thr Asp Ala Glu 
625                 630                 635                 640 


Met Lys Gln Ala Phe Glu Ile Tyr Asn Lys Asp Met Leu Ser Ser Asp 
                645                 650                 655     


Lys Lys Tyr Thr Leu Asn Asn Ile Pro Ala Ala Tyr Ala Val Met Leu 
            660                 665                 670         


Gln Asn Met Glu Thr Ile Thr Arg Val Tyr Tyr Gly Asp Leu Tyr Thr 
        675                 680                 685             


Asp Asp Gly His Tyr Met Glu Thr Lys Ser Pro Tyr Tyr Asp Thr Ile 
    690                 695                 700                 


Val Asn Leu Met Lys Ser Arg Ile Lys Tyr Val Ser Gly Gly Gln Ala 
705                 710                 715                 720 


Gln Arg Ser Tyr Trp Leu Pro Thr Asp Gly Lys Met Asp Asn Ser Asp 
                725                 730                 735     


Val Glu Leu Tyr Arg Thr Asn Glu Val Tyr Thr Ser Val Arg Tyr Gly 
            740                 745                 750         


Lys Asp Ile Met Thr Ala Asn Asp Thr Glu Gly Ser Lys Tyr Ser Arg 
        755                 760                 765             


Thr Ser Gly Gln Val Thr Leu Val Ala Asn Asn Pro Lys Leu Asn Leu 
    770                 775                 780                 


Asp Gln Ser Ala Lys Leu Asn Val Glu Met Gly Lys Ile His Ala Asn 
785                 790                 795                 800 


Gln Lys Tyr Arg Ala Leu Ile Val Gly Thr Ala Asp Gly Ile Lys Asn 
                805                 810                 815     


Phe Thr Ser Asp Ala Asp Ala Ile Ala Ala Gly Tyr Val Lys Glu Thr 
            820                 825                 830         


Asp Ser Asn Gly Val Leu Thr Phe Gly Ala Asn Asp Ile Lys Gly Tyr 
        835                 840                 845             


Glu Thr Phe Asp Met Ser Gly Phe Val Ala Val Trp Val Pro Val Gly 
    850                 855                 860                 


Ala Ser Asp Asn Gln Asp Ile Arg Val Ala Pro Ser Thr Glu Ala Lys 
865                 870                 875                 880 


Lys Glu Gly Glu Leu Thr Leu Lys Ala Thr Glu Ala Tyr Asp Ser Gln 
                885                 890                 895     


Leu Ile Tyr Glu Gly Phe Ser Asn Phe Gln Thr Ile Pro Asp Gly Ser 
            900                 905                 910         


Asp Pro Ser Val Tyr Thr Asn Arg Lys Ile Ala Glu Asn Val Asp Leu 
        915                 920                 925             


Phe Lys Ser Trp Gly Val Thr Ser Phe Glu Met Ala Pro Gln Phe Val 
    930                 935                 940                 


Ser Ala Asp Asp Gly Thr Phe Leu Asp Ser Val Ile Gln Asn Gly Tyr 
945                 950                 955                 960 


Ala Phe Ala Asp Arg Tyr Asp Leu Ala Met Ser Lys Asn Asn Lys Tyr 
                965                 970                 975     


Gly Ser Lys Glu Asp Leu Arg Asp Ala Leu Lys Ala Leu His Lys Ala 
            980                 985                 990         


Gly Ile Gln Ala Ile Ala Asp Trp  Val Pro Asp Gln Ile  Tyr Gln Leu 
        995                 1000                 1005             


Pro Gly  Lys Glu Val Val Thr  Ala Thr Arg Thr Asp  Gly Ala Gly 
    1010                 1015                 1020             


Arg Lys  Ile Ala Asp Ala Ile  Ile Asp His Ser Leu  Tyr Val Ala 
    1025                 1030                 1035             


Asn Ser  Lys Ser Ser Gly Lys  Asp Tyr Gln Ala Lys  Tyr Gly Gly 
    1040                 1045                 1050             


Glu Phe  Leu Ala Glu Leu Lys  Ala Lys Tyr Pro Glu  Met Phe Lys 
    1055                 1060                 1065             


Val Asn  Met Ile Ser Thr Gly  Lys Pro Ile Asp Asp  Ser Val Lys 
    1070                 1075                 1080             


Leu Lys  Gln Trp Lys Ala Glu  Tyr Phe Asn Gly Thr  Asn Val Leu 
    1085                 1090                 1095             


Glu Arg  Gly Val Gly Tyr Val  Leu Ser Asp Glu Ala  Thr Gly Lys 
    1100                 1105                 1110             


Tyr Phe  Thr Val Thr Lys Glu  Gly Asn Phe Ile Pro  Leu Gln Leu 
    1115                 1120                 1125             


Thr Gly  Lys Glu Lys Val Ile  Thr Gly Phe Ser Ser  Asp Gly Lys 
    1130                 1135                 1140             


Gly Ile  Thr Tyr Phe Gly Thr  Ser Gly Thr Gln Ala  Lys Ser Ala 
    1145                 1150                 1155             


Phe Val  Thr Phe Asn Gly Asn  Thr Tyr Tyr Phe Asp  Ala Arg Gly 
    1160                 1165                 1170             


His Met  Val Thr Asn Ser Glu  Tyr Ser Pro Asn Gly  Lys Asp Val 
    1175                 1180                 1185             


Tyr Arg  Phe Leu Pro Asn Gly  Ile Met Leu Ser Asn  Ala Phe Tyr 
    1190                 1195                 1200             


Ile Asp  Ala Asn Gly Asn Thr  Tyr Leu Tyr Asn Ser  Lys Gly Gln 
    1205                 1210                 1215             


Met Tyr  Lys Gly Gly Tyr Thr  Lys Phe Asp Val Ser  Glu Thr Asp 
    1220                 1225                 1230             


Lys Asp  Gly Lys Glu Ser Lys  Val Val Lys Phe Arg  Tyr Phe Thr 
    1235                 1240                 1245             


Asn Glu  Gly Val Met Ala Lys  Gly Val Thr Val Ile  Asp Gly Phe 
    1250                 1255                 1260             


Thr Gln  Tyr Phe Gly Glu Asp  Gly Phe Gln Ala Lys  Asp Lys Leu 
    1265                 1270                 1275             


Val Thr  Phe Lys Gly Lys Thr  Tyr Tyr Phe Asp Ala  His Thr Gly 
    1280                 1285                 1290             


Asn Gly  Ile Lys Asp Thr Trp  Arg Asn Ile Asn Gly  Lys Trp Tyr 
    1295                 1300                 1305             


Tyr Phe  Asp Ala Asn Gly Val  Ala Ala Thr Gly Ala  Gln Val Ile 
    1310                 1315                 1320             


Asn Gly  Gln Lys Leu Tyr Phe  Asn Glu Asp Gly Ser  Gln Val Lys 
    1325                 1330                 1335             


Gly Gly  Val Val Lys Asn Ala  Asp Gly Thr Tyr Ser  Lys Tyr Lys 
    1340                 1345                 1350             


Glu Gly  Phe Gly Glu Leu Val  Thr Asn Glu Phe Phe  Thr Thr Asp 
    1355                 1360                 1365             


Gly Asn  Val Trp Tyr Tyr Ala  Gly Ala Asn Gly Lys  Thr Val Thr 
    1370                 1375                 1380             


Gly Ala  Gln Val Ile Asn Gly  Gln His Leu Tyr Phe  Asn Ala Asp 
    1385                 1390                 1395             


Gly Ser  Gln Val Lys Gly Gly  Val Val Lys Asn Ala  Asp Gly Thr 
    1400                 1405                 1410             


Tyr Ser  Lys Tyr Asn Ala Ser  Thr Gly Glu Arg Leu  Thr Asn Glu 
    1415                 1420                 1425             


Phe Phe  Thr Thr Gly Asp Asn  Asn Trp Tyr Tyr Ile  Gly Ala Asn 
    1430                 1435                 1440             


Gly Lys  Ser Val Thr Gly Glu  Val Lys Ile Gly Asp  Asp Thr Tyr 
    1445                 1450                 1455             


Phe Phe  Ala Lys Asp Gly Lys  Gln Val Lys Gly Gln  Thr Val Ser 
    1460                 1465                 1470             


Ala Gly  Asn Gly Arg Ile Ser  Tyr Tyr Tyr Gly Asp  Ser Gly Lys 
    1475                 1480                 1485             


Arg Ala  Val Ser Thr Trp Ile  Glu Ile Gln Pro Gly  Val Tyr Val 
    1490                 1495                 1500             


Tyr Phe  Asp Lys Asn Gly Leu  Ala Tyr Pro Pro Arg  Val Leu Asn 
    1505                 1510                 1515             


