                         SEQUENCE LISTING

<110>  Codexis, Inc.
       CABIROL, Fabien
       CHEN, Haibin
       GOHEL, Anupam
       HSIEH, Helen
       PHAM, Son
       SALIM, Paulina
       SMITH, Derek
       TANG, Weng Lin
       KOSJEK, Birgit
       JANEY, Jacob
 
<120>  BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF SUBSTITUTED LACTAMS

<130>  CX2-097WO2

<160>  854

<170>  PatentIn version 3.5

<210>  1
<211>  990
<212>  DNA
<213>  Arthrobacter sp. KNK168

<400>  1
atggcattca gcgccgatac ctccgagatc gtctacacgc acgacaccgg cctcgactac       6
atcacttata gcgactacga actcgatcct gctaacccgc tcgcgggagg tgcggcatgg      12
atcgagggtg cattcgtgcc gccgtcggag gcgcggatct cgatcttcga tcagggttac      18
ctccactcgg acgtcaccta cacggtcttc cacgtctgga acggaaatgc attccgcctc      24
gacgaccaca tcgaacgcct cttctccaac gcggagtcga tgcgcatcat ccctccgctc      30
acacaggacg aagtgaagga gattgcgctc gaactcgtcg cgaagaccga attgcgtgag      36
gccttcgtgt ccgtgtcgat tacccgcggt tacagctcga ctccgggcga gcgcgacatc      42
acgaagcacc gcccgcaggt gtacatgtat gccgtcccat atcagtggat cgtgccgttt      48
gaccgaattc gcgacggcgt gcacgccatg gtcgcacaga gcgtgcgccg aaccccgcgc      54
agctcgatcg accctcaggt caagaacttc cagtgggggg atctgatccg tgcggttcaa      60
gagacgcacg accgcgggtt cgaggctccc cttctgctcg acggcgatgg actgcttgcc      66
gagggctcgg ggttcaacgt cgtcgtgatc aaggacggcg tcgtgcgcag cccgggtcga      72
gcggcgctcc ccggcattac gcggaagacc gtgctcgaga tcgccgaatc gctcggacac      78
gaggcgattc tcgccgacat cacgctcgct gaactgctcg acgccgacga agtgctcggc      84
tgcacgactg cgggcggagt gtggccattc gtcagcgtgg acggcaaccc catctcggac      90
ggggttcccg gccccatcac ccagtcgatc atccgtcgtt actgggagct gaatgtcgag      96
agctcgtcgt tgcttacgcc tgtgcagtac                                       990


<210>  2
<211>  330
<212>  PRT
<213>  Arthrobacter sp. KNK168

<400>  2
Met Ala Phe Ser Ala Asp Thr Ser Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Tyr Leu His Ser Asp 
    50                  55                  60                  
Val Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Asp Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Met Arg Ile 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Phe Val Ser Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Gly Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Ala Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Val Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Ala Pro Leu Leu Leu Asp Gly Asp Gly Leu Leu Ala Glu Gly Ser Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Leu Ala Glu Leu 
            260                 265                 270         
Leu Asp Ala Asp Glu Val Leu Gly Cys Thr Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Pro Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Ile Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Ser Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 

<210>  3
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  3
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  4
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  4

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  5
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  5
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tataattctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  6
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  6

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Asn Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  7
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  7
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccacgttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  8
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  8

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  9
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  9
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgttt gggtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgcccagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgaccct ggtacagtac                                       990


<210>  10
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  1
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Leu Val Gln Tyr 
                325                 330 


<210>  11
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  11
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgttgctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgctccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  12
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  12

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Ala Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  13
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  13
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  14
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  14

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  15
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  15
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  16
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  16

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  17
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  17
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagaatggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  18
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  18

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Asn 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  19
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  19
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  20
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  2
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ser 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  21
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  21
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg tgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  22
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  22

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Val Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  23
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  23
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagatgccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctggc      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  24
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  24

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Met Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Gly Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  25
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  25
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  26
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  26

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  27
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  27
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgtttgttt ttgtttcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gcttttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagatgccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg ttggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  28
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  28

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Phe Val Phe Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Phe Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Met Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Val Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  29
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  29
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tataattctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt ttgttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  30
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  3
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Asn Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Phe Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  31
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  31
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt ttgttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgctccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagagcggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg ttggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  32
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  32

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Phe Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Ala Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ser 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Val Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  33
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  33
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  34
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  34

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  35
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  35
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatgcttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  36
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  36

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Ala Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  37
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  37
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgttt tggtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  38
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  38

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Leu Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  39
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  39
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta aggtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  40
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  4
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Lys Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  41
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  41
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg accatgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc acccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  42
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  42

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Thr Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  43
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  43
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaacca ctggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  44
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  44

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Thr Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  45
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  45
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatttga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  46
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  46

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  47
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  47
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgtttgttt gggtttcaat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgctt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagatgccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg ttggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  48
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  48

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Phe Val Trp Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Leu 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Met Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Val Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  49
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  49
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgtgggttt ttgtttcaat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagatgccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg ttggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  50
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  5
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Trp Val Phe Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Met Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Val Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  51
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  51
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgtgggttt ttgttgcaat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaact gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg ttggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  52
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  52

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Trp Val Phe Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Val Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  53
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  53
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt ttgttgcaat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc catctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  54
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  54

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Phe Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  55
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  55
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatca gtatcttcga ccagggtttt      18
tatacttctg atgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgatata      42
accaaagtcc gtccgcaggt ttacatgtct gctgttccgt accaaacgat tgtagggttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgattcg tgcaattcag      60
gaaacccacg accgtggttt cgagctgccg ctgctgctgg accatgacaa cctgctggct      66
gaaggttcgg gtttcaacat tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  56
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  56

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys Val Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Val Pro Tyr Gln Thr Ile Val Gly Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Ser Gly 
    210                 215                 220                 
Phe Asn Ile Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  57
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  57
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatcc ccatcgaaga ccagggtttt      18
tatacttctt gcgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgaaaaa      42
accaaagtcc gtccgcaggt ttacatgtct gctgttccgt accaaacgat tgtacctttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgattcg tgcaattcag      60
gaaacccacg accgtggttt cgagctgccg ctgctgctgg accatgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  58
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  58

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Glu Asp Gln Gly Phe Tyr Thr Ser Cys 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Glu Lys Thr Lys Val Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Val Pro Tyr Gln Thr Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  59
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  59
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgataaa      42
accaaagtcc gtccgcaggt ttacatgtat gctgttccgt acatcacgct tgtacctttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgattcg tgcagttcag      60
gaaacccacg accgtggttt cgagctgccg ctgctgctgg accatgacaa cctgctggct      66
gaaggttcgg gtttcaacat tgttgttatc acagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  60
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  6
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Lys Thr Lys Val Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Ile Thr Leu Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Val Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Ser Gly 
    210                 215                 220                 
Phe Asn Ile Val Val Ile Thr Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  61
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  61
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatca gtatcttcga ccagggtttt      18
tatacttctg atgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgataaa      42
accaaacatc gtccgcaggt ttacatgtct gctgttccgt acatctggat tgtacctttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgcttcg tgcaattcag      60
gaaacccacg accgtggttt cgagctgccg ctgctgctgg accatgacaa cctgctggct      66
gaaggtccgg gtttcaacat tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  62
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  62

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Lys Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Val Pro Tyr Ile Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Leu Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Ile Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  63
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  63
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatcc ccatcttcga ccagggtttt      18
tatacttctt gcgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgatata      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt acatcacgct tgtacctttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgattcg tgcaattcag      60
gaaacccacg accgtggttt cgagctgccg ctgctgctgg accatgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  64
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  64

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Cys 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Ile Thr Leu Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  65
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  65
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatcc ccatcttcga ccagggtttt      18
tatacttctt gcgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccatggga gcgtgaaata      42
accaaagtcc gtccgcaggt ttacatgtat gctgttccgt acatctggct tgtagggttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgattcg tgcagttcag      60
gaaacccacg accgtggttt cgagctgccg ctgctgctgg accatgacaa cctgctggct      66
gaaggtccgg gtttcaacat tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  66
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  66

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Cys 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Glu Ile Thr Lys Val Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Ile Trp Leu Val Gly Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Val Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Ile Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  67
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  67
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatcc tcatcttcga ccagggtttt      18
tatacttctt gcgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagctgccg ctgctgctgg accatgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  68
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  68

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Leu Ile Phe Asp Gln Gly Phe Tyr Thr Ser Cys 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  69
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  69
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatcc tcatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg accatgacaa cctgctggct      66
gaaggttcgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  70
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  7
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Leu Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Ser Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  71
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  71
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatcc tcatcttcga ccagggtttt      18
tatacttctg atgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgatata      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt acatcacgct tgtacctttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgattcg tgcaattcag      60
gaaacccacg accgtggttt cgagctgccg ctgctgctgg accatgacaa cctgctggct      66
gaaggttcgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gcccggttac ccagtctatc atccgtcgtt actgggaact gaacgtcgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  72
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  72

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Leu Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Ile Thr Leu Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Ser Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  73
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  73
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccatttga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  74
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  74

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  75
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  75
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gcttggccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  76
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  76

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Trp Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  77
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  77
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctattccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  78
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  78

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Ile Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  79
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  79
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctctgccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  80
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  8
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Leu Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  81
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  81
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagagtggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  82
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  82

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ser 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  83
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  83
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  84
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  84

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  85
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  85
atggcgttct cagcggacac ccctgaaatc gtttacgccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcacatct ctatcttcga ccagggtttt      18
tatacatctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cgcccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctcttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt caagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggacgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgccgacccc ggtacagtac                                       990


<210>  86
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  86

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Ala His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala His Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Ala 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Leu Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Lys 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Pro Thr Pro Val Gln Tyr 
                325                 330 


<210>  87
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  87
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc ttgctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tataattctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtaacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctcaatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  88
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  88

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Asn Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asn Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  89
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  89
atggcgttct cagcggacac ccctgaaatc gttcacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtcag      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta ttgtttctat cacccgtggt tactcttctt ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagtttgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcatctc tgctgacccc ggtacagtac                                       990


<210>  90
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  9
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val His Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Gln 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Ser Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Cys 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  91
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  91
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tggacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  92
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  92

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Trp Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  93
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  93
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
ggtacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  94
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  94

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Gly Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  95
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  95
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tattcttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  96
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  96

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Ser Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  97
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  97
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatttgtctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  98
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  98

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Leu Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  99
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  99
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgcgttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  100
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  10
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Ala Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  101
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  101
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgtttgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcgcctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  102
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  102

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Phe Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val Arg Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  103
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  103
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgtgggtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  104
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  104

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Trp Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  105
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  105
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgtatgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  106
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  106

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Tyr Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  107
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  107
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgtttgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  108
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  108

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Phe Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  109
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  109
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta aggtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  110
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  11
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Lys Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  111
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  111
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta atgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  112
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  112

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Asn Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  113
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  113
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgttc tggtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  114
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  114

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Leu Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  115
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  115
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgttt ttgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  116
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  116

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Phe Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  117
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  117
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgttgctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  118
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  118

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  119
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  119
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgttattat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  120
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  12
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ile Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  121
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  121
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccaatgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  122
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  122

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Met Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  123
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  123
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca ccgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  124
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  124

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Thr Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  125
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  125
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatatga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  126
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  126

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Tyr Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  127
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  127
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccaaagga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  128
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  128

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Lys Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  129
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  129
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgctt gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  130
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  13
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Leu Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  131
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  131
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gcttttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  132
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  132

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Phe Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  133
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  133
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gcttggccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttttggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  134
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  134

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Trp Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  135
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  135
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagcatggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  136
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  136

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln His 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  137
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  137
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  138
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  138

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Gly 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  139
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  139
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagcagggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  140
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  14
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Gln 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  141
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  141
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagaagggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  142
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  142

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Lys 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  143
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  143
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagcggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  144
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  144

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Arg 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  145
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  145
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccc cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  146
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  146

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Pro Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  147
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  147
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaacca gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  148
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  148

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ser Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  149
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  149
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  150
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  15
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  151
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  151
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacactgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagcagccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  152
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  152

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Gln Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  153
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  153
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagatgccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  154
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  154

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Met Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  155
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  155
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcggaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgttcgtta ttgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtcc gctgtgccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggcc gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  156
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  156

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Phe Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  157
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  157
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgttcgtta ttgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtac gcttgcccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggttccg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agtcctgggt      84
tgctctaccg ggggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  158
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  158

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Phe Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Cys Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Ser Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  159
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  159
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatggtta ttgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggttccg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  160
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  16
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Ser Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  161
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  161
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatggtta ttgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtac gcttgcccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  162
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  162

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Cys Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Gly 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  163
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  163
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgttcgtta ttgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtcc gctgtgccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggttccg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctctaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  164
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  164

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Phe Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Ser Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  165
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  165
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgttcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgttacg tgcagtccag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgcgtgaccg ttggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  166
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  166

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Phe Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Leu Arg Ala Val Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Val Thr Val Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  167
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  167
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtgtgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  168
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  168

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Val Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  169
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  169
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgttacg tgcaatccag      60
gaaacccacg accgtggttt cgaggttccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgcatcaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  170
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  17
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Leu Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Val Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ile Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  171
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  171
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta catcgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgttcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctggtccg tgcactgcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtaccg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgcctgaccg ttggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgga      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  172
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  172

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Ile Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Phe Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Val Arg Ala Leu Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Thr Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Leu Thr Val Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Gly 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  173
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  173
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgttcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtgactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  174
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  174

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Phe Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asp Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  175
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  175
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcagtccag      60
gaaacccacg accgtggttt cgaggttccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  176
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  176

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Val Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Val Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  177
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  177
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgttcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtgtgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg ctggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  178
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  178

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Phe Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Val Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  179
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  179
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgttcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagtttccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  180
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  18
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Phe Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Phe Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  181
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  181
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagagcggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg ttggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atctgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  182
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  182

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ser 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Val Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Cys Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  183
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  183
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt gggttgcaac cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gcttttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagagcggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg ttggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  184
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  184

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Thr Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Phe Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ser 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Val Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  185
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  185
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgtttgttt gggtttcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgctccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagaacggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagatgccg ctgctgctgg actgtgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg ttggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  186
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  186

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Phe Val Trp Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Ala Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Asn 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Met Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Val Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  187
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  187
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt gggtttcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagagcggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  188
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  188

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ser 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  189
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  189
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt ttgttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gcttttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg ttggtggtgt ttggccgttc gtttctgtcg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  190
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  19
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Phe Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Phe Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Val Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  191
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  191
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgtttgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gcttttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg ttggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  192
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  192

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Phe Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Phe Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Val Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  193
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  193
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt gggtttcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gcttttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg ttggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  194
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  194

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Phe Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Val Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  195
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  195
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg cttttgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgtttgttt ttgttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgctccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagaacggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagatgccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg ttggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  196
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  196

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Phe Val Phe Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Ala Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Asn 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Met Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Val Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  197
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  197
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgttt gggtttctat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggccggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  198
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  198

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  199
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  199
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccagggcg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgttt gggtttctat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggccggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagatgccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg tcggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  200
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  20
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Gly Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Met Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Val Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  201
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  201
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgttt gggtttctat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggccggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgcacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  202
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  202

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
His Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  203
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  203
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgttt gggtttctat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtccggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg tcggtggtgt ttggccgttc gtttctgttg acagtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  204
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  204

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ser 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Val Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Ser Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  205
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  205
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgttt gggtttctat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggccggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg tcggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  206
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  206

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Val Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  207
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  207
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgttt gggtttctat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc cagtccggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg ttggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  208
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  208

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ser 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Val Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  209
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  209
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgttc gggtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  210
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  21
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Arg Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  211
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  211
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggatccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgttt ttgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctaacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  212
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  212

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Phe Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asn Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  213
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  213
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgcttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta aggtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  214
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  214

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Ala Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Lys Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  215
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  215
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  216
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  216

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  217
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  217
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tggtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  218
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  218

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Met Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  219
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  219
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgttattat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  220
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  22
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ile Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  221
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  221
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgttgcgat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  222
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  222

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  223
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  223
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgttacgat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  224
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  224

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  225
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  225
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttgtat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  226
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  226

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Cys Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  227
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  227
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctggtccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  228
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  228

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Gly Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  229
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  229
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgctccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  230
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  23
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Ala Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  231
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  231
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gcttctccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  232
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  232

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Ser Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  233
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  233
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg accatgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  234
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  234

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  235
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  235
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg accttgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  236
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  236

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Leu Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  237
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  237
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacat tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  238
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  238

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Ile Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  239
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  239
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccactttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  240
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  24
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  241
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  241
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgggttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  242
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  242

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Gly Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  243
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  243
atggcgttct cagcggacac ccccgaaatc gtttacttcc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatcg cgatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  244
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  244

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Phe His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ala Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  245
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  245
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatcc ggatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  246
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  246

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Arg Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  247
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  247
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggct ggtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  248
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  248

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Leu Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  249
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  249
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt acctgtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  250
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  25
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Leu Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  251
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  251
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt acatttggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  252
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  252

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Ile Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  253
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  253
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaagttc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  254
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  254

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys Val Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  255
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  255
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagacgat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  256
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  256

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Thr Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  257
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  257
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaggtttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  258
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  258

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Gly Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  259
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  259
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacaag      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc aggtgacccc ggtacagtac                                       990


<210>  260
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  26
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Lys Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Gln Val Thr Pro Val Gln Tyr 
                325                 330 


<210>  261
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  261
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  262
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  262

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  263
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  263
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcgatga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc cttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  264
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  264

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Asp Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  265
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  265
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcgagga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  266
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  266

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Glu Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  267
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  267
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt acacgtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  268
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  268

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  269
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  269
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accaggcgat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  270
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  27
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Ala Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  271
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  271
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtcgat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  272
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  272

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Ser Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  273
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  273
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgagatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  274
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  274

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Glu Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  275
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  275
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgctccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagatgccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg ttggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  276
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  276

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Ala Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Met Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Val Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  277
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  277
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gcttttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagatgccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg ttggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  278
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  278

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Phe Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Met Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Val Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  279
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  279
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgtgggttt gggtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  280
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  28
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Trp Val Trp Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  281
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  281
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgtgggttt gggttgcaat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagatgccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg ttggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  282
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  282

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Trp Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Met Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Val Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  283
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  283
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcagaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctagaaccgt actgcgtgaa      36
gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgctccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagatgccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg ttggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  284
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  284

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Arg Thr Val Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Ala Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Met Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Val Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  285
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  285
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgtgggttt gggtttcaat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagatgccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  286
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  286

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Trp Val Trp Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Met Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  287
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  287
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt gggtttcaat cacccgtggt tactcttcta ccccatggga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagatgccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacgt caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  288
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  288

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Met Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Val Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  289
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  289
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt ttgtttcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gcttttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggctggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg ttggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  290
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  29
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Phe Val Ser Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Phe Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Val Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  291
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  291
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatca gtatcttcga ccagggtttt      18
tatacttctt gcgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgaaata      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accaatggat tgtacctttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgattcg tgcagttcag      60
gaaacccacg accgtggttt cgagctgccg ctgctgctgg accatgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  292
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  292

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Cys 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Glu Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Val Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  293
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  293
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatcc tcatcttcga ccagggtttt      18
tatacttctt gcgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgataaa      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accaatggat tgtacctttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgattcg tgcagttcag      60
gaaacccacg accgtggttt cgagctgccg ctgctgctgg accatgacaa cctgctggct      66
gaaggtccgg gtttcaacat tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgtcgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  294
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  294

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Leu Ile Phe Asp Gln Gly Phe Tyr Thr Ser Cys 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Lys Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Val Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Ile Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  295
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  295
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatca gtatcttcga ccagggtttt      18
tatacttctg atgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgatata      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt acatctggct tgtacctttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgattcg tgcagttcag      60
gaaacccacg accgtggttt cgagctgccg ctgctgctgg accatgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  296
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  296

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Ile Trp Leu Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Val Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  297
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  297
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatcc ccatcttcga ccagggtttt      18
tatacttctt gcgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgatata      42
accaaagtcc gtccgcaggt ttacatgtat gctgttccgt accaatggct tgtagggttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgattcg tgcagttcag      60
gaaacccacg accgtggttt cgagctgccg ctgctgctgg accatgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccctggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  298
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  298

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Cys 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys Val Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Leu Val Gly Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Val Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Leu Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  299
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  299
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatcc tcatcttcga ccagggtttt      18
tatacttctt gcgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgatata      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt acatcacgct tgtacctttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgattcg tgcaattcag      60
gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacat tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  300
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  30
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Leu Ile Phe Asp Gln Gly Phe Tyr Thr Ser Cys 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Ile Thr Leu Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Ile Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  301
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  301
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatca gtatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgattcg tgcagttcag      60
gaaacccacg accgtggttt cgagctgccg ctgctgctgg accatgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  302
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  302

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Val Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  303
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  303
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       6
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      12
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      18
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      24
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      30
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      36
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc      42
accaaacatc gtccgcaggt ttacatgtat gctcgtccgt accagtggat cgtaccgttt      48
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      54
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag      60
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      66
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      72
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      78
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      84
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      90
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      96
ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  304
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  304

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Arg Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 

 
<210> 305
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 305
atgatgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 306
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 306
Met Met Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 307
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 307
atggcgttct caacggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 308
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 308
Met Ala Phe Ser Thr Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 309
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 309
atggcgttct cagcggacac cccttttatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 310
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 310
Met Ala Phe Ser Ala Asp Thr Pro Phe Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 311
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 311
atggcgttct caccagacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 312
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 312
Met Ala Phe Ser Pro Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 313
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 313
atggcgttct cagcgtttac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 314
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 314
Met Ala Phe Ser Ala Phe Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 315
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 315
atggcgttct cagcggacac ccctgaactt gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 316
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 316
Met Ala Phe Ser Ala Asp Thr Pro Glu Leu Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 317
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 317
atggcgttct caaacgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 318
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 318
Met Ala Phe Ser Asn Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 319
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 319
atggcgttct cagcggacac ccatgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 320
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 320
Met Ala Phe Ser Ala Asp Thr His Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 321
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 321
atggcgttct caatcgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 322
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 322
Met Ala Phe Ser Ile Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 323
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 323
atggcgttct cattggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 324
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 324
Met Ala Phe Ser Leu Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 325
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 325
atggcgttct tagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 326
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 326
Met Ala Phe Leu Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 327
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 327
atggcgttct catgtgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 328
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 328
Met Ala Phe Ser Cys Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 329
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 329
atggcgttct cagcgtctac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 330
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 330
Met Ala Phe Ser Ala Ser Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 331
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 331
atggcgttct ttgcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 332
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 332
Met Ala Phe Phe Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 333
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 333
atggcgttct cagcggacac ccctttaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 334
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 334
Met Ala Phe Ser Ala Asp Thr Pro Leu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 335
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 335
atggcgttct caaaggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 336
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 336
Met Ala Phe Ser Lys Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 337
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 337
atggcgttct cagcggacac ccctataatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 338
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 338
Met Ala Phe Ser Ala Asp Thr Pro Ile Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 339
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 339
atggcgttct cagcgcgtac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 340
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 340
Met Ala Phe Ser Ala Arg Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 341
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 341
atggcgttct cagcggacac ccctcaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 342
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 342
Met Ala Phe Ser Ala Asp Thr Pro Gln Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 343
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 343
atggcgttct atgcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 344
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 344
Met Ala Phe Tyr Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 345
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 345
atggcgttct cagcgacaac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 346
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 346
Met Ala Phe Ser Ala Thr Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 347
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 347
atggcgttct cacacgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 348
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 348
Met Ala Phe Ser His Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 349
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 349
atggcgttct catacgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 350
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 350
Met Ala Phe Ser Tyr Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 351
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 351
atggcgttct catttgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 352
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 352
Met Ala Phe Ser Phe Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 353
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 353
atggcgttct caatggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 354
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 354
Met Ala Phe Ser Met Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 355
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 355
atggcgttct cagtagacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 356
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 356
Met Ala Phe Ser Val Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 357
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 357
atggcgttct catctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 358
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 358
Met Ala Phe Ser Ser Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 359
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 359
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatgcgtctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 360
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 360
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Ala Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 361
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 361
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt ttgttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 362
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 362
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Phe Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 363
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 363
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt tggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 364
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 364
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Leu Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 365
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 365
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttctt ggccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 366
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 366
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Trp Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 367
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 367
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccatttga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 368
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 368
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 369
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 369
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacatg caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 370
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 370
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Met Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 371
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 371
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 372
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 372
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 373
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 373
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 374
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 374
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Leu Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 375
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 375
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg accatgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 376
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 376
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 377
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 377
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcgcttact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 378
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 378
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Ala Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 379
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 379
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
agggctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 380
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 380
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Arg Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 381
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 381
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atccattact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 382
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 382
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile His Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 383
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 383
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagagtat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 384
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 384
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Ser Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 385
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 385
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tattgactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 386
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 386
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Ile Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 387
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 387
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgcgtacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 388
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 388
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Ala Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 389
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 389
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccct gctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 390
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 390
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Leu Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 391
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 391
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacct gctggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 392
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 392
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Leu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 393
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 393
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacggg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 394
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 394
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Gly Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 395
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 395
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatca tgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 396
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 396
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Met Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 397
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 397
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg cataacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 398
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 398
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro His Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 399
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 399
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg cggaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 400
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 400
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Arg Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 401
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 401
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgg ttgctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 402
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 402
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Val Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 403
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 403
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacca tctggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 404
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 404
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr His Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 405
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 405
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actgaatccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 406
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 406
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asn Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 407
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 407
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacttt gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaagtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 408
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 408
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Phe Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Ser Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 409
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 409
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actgacgccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 410
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 410
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Thr Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 411
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 411
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga aaatgacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 412
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 412
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Asn Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 413
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 413
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactaccc tctggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 414
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 414
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Pro Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 415
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 415
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacgcg 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 416
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 416
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ala Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 417
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 417
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaggt ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 418
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 418
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Gly Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 419
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 419
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacacg 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 420
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 420
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Thr Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 421
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 421
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaagtgc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcga 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 422
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 422
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys Val Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 423
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 423
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatg 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 424
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 424
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Met Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 425
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 425
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatca ggatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 426
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 426
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Arg Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 427
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 427
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtcttcg gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 428
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 428
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Ser Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 429
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 429
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgattgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 430
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 430
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ile Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 431
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 431
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttag gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 432
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 432
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Arg Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 433
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 433
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgcc tccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 434
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 434
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Pro Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 435
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 435
atggcgttct cagcggacac ccccgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcttgcgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 436
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 436
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Leu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 437
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 437
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
accactgacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 438
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 438
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Thr Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 439
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 439
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 440
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 440
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 441
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 441
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acctgggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 442
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 442
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Trp Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 443
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 443
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaaagcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 444
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 444
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Lys Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 445
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 445
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
atgcgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 446
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 446
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Met Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 447
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 447
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcgggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 448
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 448
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Arg Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 449
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 449
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtc tggttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 450
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 450
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Leu Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 451
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 451
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacgatg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 452
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 452
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Asp Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 453
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 453
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccacggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 454
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 454
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Thr Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 455
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 455
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacc tggctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 456
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 456
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Leu Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 457
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 457
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgaggg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 458
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 458
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 459
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 459
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtagttc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 460
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 460
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Ser Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 461
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 461
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggttggtc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 462
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 462
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Trp Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 463
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 463
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tgtatgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 464
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 464
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Tyr Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 465
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 465
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tgtgggacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 466
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 466
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Trp Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 467
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 467
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactggtgg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 468
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 468
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Val Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 469
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 469
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccgcgt gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 470
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 470
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Arg Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 471
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 471
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactggatg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 472
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 472
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Asp Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 473
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 473
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtaca cggctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 474
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 474
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Thr Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 475
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 475
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtcgttc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 476
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 476
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Arg Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 477
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 477
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtaca gggctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 478
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 478
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Arg Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 479
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 479
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtact ttgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 480
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 480
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Phe Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 481
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 481
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgatgg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 482
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 482
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Met Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 483
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 483
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtcgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg caggtggtgt ttggccgttc gtttctgttg acggtaactc tatttctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 484
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 484
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 485
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 485
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acaataactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 486
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 486
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Asn Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 487
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 487
atggcgttct cagcggacac ccatgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaacgg tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 488
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 488
Met Ala Phe Ser Ala Asp Thr His Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Gly Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 489
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 489
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctctg 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 490
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 490
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Leu Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 491
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 491
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaacga tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 492
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 492
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Asp Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 493
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 493
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttctgagc tgctgacccc ggtacagtac                                  990

 
<210> 494
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 494
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Glu Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 495
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 495
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact taacgttgaa 960
ccttcttctc tgatgacccc ggtacagtac                                  990

 
<210> 496
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 496
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Met Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 497
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 497
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atcatgcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 498
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 498
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Met Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 499
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 499
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacagggaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 500
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 500
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Arg Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 501
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 501
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgtc tgctgacccc ggtacagtac                                  990

 
<210> 502
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 502
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 503
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 503
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actggcttct gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 504
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 504
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Leu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 505
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 505
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttcag 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 506
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 506
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Gln 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 507
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 507
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actggcgtct gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 508
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 508
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Arg Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 509
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 509
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac cgcgtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 510
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 510
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Ala Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 511
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 511
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtggatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 512
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 512
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Trp Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 513
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 513
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagcttatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 514
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 514
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Leu Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 515
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 515
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtaccttac                                  990

 
<210> 516
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 516
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Pro Tyr                         
                325                 330                         

 
<210> 517
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 517
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacacggaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 518
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 518
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Thr Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 519
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 519
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaactatgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 520
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 520
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Tyr Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 521
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 521
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtcaggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 522
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 522
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Gln Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 523
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 523
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttctcggc tgctgacccc ggtacagtac                                  990

 
<210> 524
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 524
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Arg Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 525
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 525
atggcgttct caaagtctac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt ttgttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 526
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 526
Met Ala Phe Ser Lys Ser Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Phe Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 527
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 527
atggcgttct cactgtctac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt ttgttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 528
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 528
Met Ala Phe Ser Leu Ser Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Phe Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 529
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 529
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtcttct gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtaccgtac                                  990

 
<210> 530
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 530
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Ser Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Pro Tyr                         
                325                 330                         

 
<210> 531
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 531
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acctgggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtt tggttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggcc gaactgtacg atgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtcgttc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtaccgtac                                  990

 
<210> 532
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 532
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Trp Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Leu Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Arg Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Pro Tyr                         
                325                 330                         

 
<210> 533
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 533
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagctgatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 534
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 534
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Leu Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 535
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 535
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
atgcgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 536
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 536
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Met Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 537
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 537
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccgcgt gaactggttg atgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 538
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 538
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Arg Glu Leu 
            260                 265                 270         
Val Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 539
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 539
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagctgatc atccgtcgtt actgggaact gaacactgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 540
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 540
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Leu Ile Ile Arg Arg Tyr Trp Glu Leu Asn Thr Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 541
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 541
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
accacggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcgtgt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
atgcgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccgcgt gaactgtacg atgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtaccgtac                                  990

 
<210> 542
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 542
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Thr Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Arg Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Met Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Arg Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Pro Tyr                         
                325                 330                         

 
<210> 543
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 543
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcgtgt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtaccgtac                                  990

 
<210> 544
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 544
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Arg Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Pro Tyr                         
                325                 330                         

 
<210> 545
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 545
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacc tggctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacactgaa 960
ccttcttctc tgctgacccc ggtaccgtac                                  990

 
<210> 546
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 546
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Leu Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Thr Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Pro Tyr                         
                325                 330                         

 
<210> 547
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 547
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcgtgt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggcc gaactggttg atgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 548
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 548
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Arg Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Val Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 549
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 549
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggcc gaactgtacc tggctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 550
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 550
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Leu Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 551
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 551
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acctgggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggcc gaactggttg atgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtaccgtac                                  990

 
<210> 552
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 552
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Trp Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Val Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Pro Tyr                         
                325                 330                         

 
<210> 553
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 553
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggcc gaactggttc tggctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 554
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 554
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Val Leu Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 555
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 555
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
atgcgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtaccgtac                                  990

 
<210> 556
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 556
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Met Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Pro Tyr                         
                325                 330                         

 
<210> 557
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 557
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
accacggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccgcgt gaactggttc tggctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacactgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 558
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 558
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Thr Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Arg Glu Leu 
            260                 265                 270         
Val Leu Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Thr Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 559
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 559
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
accacggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggcc gaactggttc tggctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 560
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 560
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Thr Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Val Leu Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 561
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 561
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtcgttc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 562
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 562
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Arg Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 563
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 563
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acctgggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtt tggttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtaccgtac                                  990

 
<210> 564
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 564
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Trp Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Leu Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Pro Tyr                         
                325                 330                         

 
<210> 565
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 565
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagctgatc atccgtcgtt actgggaact gaacactgaa 960
ccttcttctc tgctgacccc ggtaccgtac                                  990

 
<210> 566
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 566
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Leu Ile Ile Arg Arg Tyr Trp Glu Leu Asn Thr Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Pro Tyr                         
                325                 330                         

 
<210> 567
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 567
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
atgcgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtt tggttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggcc gaactgtacg atgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacactgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 568
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 568
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Met Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Leu Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Thr Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 569
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 569
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccgcgt gaactgtacg atgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtaccgtac                                  990

 
<210> 570
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 570
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Arg Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Pro Tyr                         
                325                 330                         

 
<210> 571
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 571
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
atgcgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tgtgggacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtcgttc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtaccgtac                                  990

 
<210> 572
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 572
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Met Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Trp Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Arg Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Pro Tyr                         
                325                 330                         

 
<210> 573
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 573
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtatg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actggctgct gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 574
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 574
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Leu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 575
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 575
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtcttctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttcagttg acggttggag catctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 576
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 576
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Trp Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 577
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 577
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacacctt gctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtcttctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtttc 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgatgg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 578
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 578
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Leu Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Phe Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Met Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 579
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 579
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacacctt gctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtcgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccagaacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgatga cagccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 580
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 580
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Leu Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asn Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Met Thr Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 581
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 581
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 582
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 582
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 583
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 583
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgatga cagccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 584
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 584
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Met Thr Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 585
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 585
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacacctt gctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtcttctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtctat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgta cagccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttcagttg acggtagtag catctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 586
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 586
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Leu Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Ser Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Thr Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Ser Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 587
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 587
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacacctt gctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 588
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 588
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Leu Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 589
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 589
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacacctt gctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtcttctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttcagttg acggttggag catctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 590
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 590
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Leu Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Trp Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 591
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 591
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacacctt gctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtttc 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 592
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 592
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Leu Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Phe Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 593
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 593
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtctat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgatga cagccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 594
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 594
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Ser Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Met Thr Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 595
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 595
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacacctt gctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtttc 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgatgg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 596
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 596
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Leu Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Phe Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Met Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 597
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 597
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 598
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 598
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 599
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 599
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacacctt gctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtata cagccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 600
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 600
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Leu Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Thr Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 601
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 601
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtata cagccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 602
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 602
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Thr Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 603
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 603
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtcttctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtatg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 604
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 604
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 605
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 605
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtcttctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgatgg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 606
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 606
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Met Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 607
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 607
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 608
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 608
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 609
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 609
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtcttctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttcagttg acggtaatag catctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 610
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 610
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 611
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 611
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtcttctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtctat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgatga cagccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccagttac ccagtctatc atccgtcgtt actggctgct gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 612
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 612
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Ser Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Met Thr Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Leu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 613
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 613
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacacctt gctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtcttctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actggctgct gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 614
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 614
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Leu Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Leu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 615
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 615
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacacctt gctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgatgg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 616
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 616
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Leu Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Met Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 617
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 617
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacacctt gctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtcttctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtatg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 618
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 618
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Leu Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 619
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 619
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacacctt gctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtcttctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 620
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 620
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Leu Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 621
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 621
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacacctt gctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtttc 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtctat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgatga cagccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 622
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 622
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Leu Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Phe Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Ser Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Met Thr Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 623
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 623
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacacctt gctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtcttctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtttc 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtctat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgatga cagccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 624
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 624
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Leu Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Phe Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Ser Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Met Thr Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 625
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 625
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacacctt gctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttcagttg acggttgggg catctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 626
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 626
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Leu Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Trp Gly Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 627
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 627
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacacctt gctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtatg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 628
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 628
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Leu Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 629
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 629
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtcttctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 630
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 630
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 631
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 631
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gagctctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtt tagccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtcgttc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 632
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 632
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Leu Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Arg Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 633
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 633
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gagctctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaaaacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 634
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 634
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asn Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 635
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 635
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gagctctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtcgttc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 636
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 636
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Arg Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 637
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 637
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gagctctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 638
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 638
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 639
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 639
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gagctctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaaaacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtagttc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 640
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 640
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asn Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Ser Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 641
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 641
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gagctctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtagttc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 642
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 642
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Ser Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 643
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 643
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gagctctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtgctctaat gcggaatcta ttcgtttgat cccgccgctg 300
accacaaacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 644
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 644
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Cys Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Thr Asn Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 645
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 645
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gagctctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
accacagacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtagttc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 646
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 646
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Thr Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Ser Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 647
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 647
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
ctgacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 648
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 648
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Leu Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 649
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 649
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gggttctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 650
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 650
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Gly 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 651
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 651
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gcggtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 652
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 652
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Arg 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 653
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 653
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctgctta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccaccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 654
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 654
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Ala Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 655
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 655
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatctggga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 656
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 656
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Trp Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 657
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 657
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tattgttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 658
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 658
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Cys Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 659
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 659
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctagtta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 660
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 660
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Ser Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 661
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 661
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtggtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 662
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 662
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Trp 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 663
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 663
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgttg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt ttgttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 664
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 664
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Phe Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 665
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 665
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggg tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgcagacccc ggtacagtac                                  990

 
<210> 666
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 666
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Gln Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 667
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 667
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttggtat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggcgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 668
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 668
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Gly Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 669
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 669
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttctg ttccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgag 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 670
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 670
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Val Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 671
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 671
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttctg ggccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 672
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 672
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Gly Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 673
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 673
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttctt atccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 674
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 674
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Tyr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 675
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 675
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccatatga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 676
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 676
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Tyr Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 677
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 677
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttctc tgccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 678
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 678
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Leu Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 679
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 679
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accatgcatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 680
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 680
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Met His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 681
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 681
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt acctttggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 682
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 682
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Leu Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 683
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 683
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acgcgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 684
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 684
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Ala Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 685
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 685
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt acatttggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgaattaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 686
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 686
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Ile Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 687
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 687
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttagct ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 688
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 688
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Ala Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 689
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 689
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc tcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac tcagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 690
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 690
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ser Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 691
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 691
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc ggggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 692
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 692
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gly Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 693
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 693
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaggg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 694
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 694
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Gly Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 695
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 695
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 696
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 696
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 697
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 697
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagagtggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 698
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 698
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ser 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 699
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 699
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggcg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaagt ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 700
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 700
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Ser Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 701
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 701
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgcctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggttctg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 702
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 702
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Pro Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Ser Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 703
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 703
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtgcgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 704
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 704
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Ala Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 705
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 705
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgcactaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 706
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 706
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Thr Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 707
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 707
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt ttctcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt acttgtttat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 708
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 708
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Phe Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Leu Phe Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 709
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 709
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt actgttttat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc caggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 710
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 710
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Cys Phe Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

<210> 711
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 711
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggttcag gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgcaccaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 712
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 712
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Ser Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Thr Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 713
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 713
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatctggga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc agcgcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaggc ctgctgctgg actttgacaa cctgctggct 660
gaaggtgcgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgcaccaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 714
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 714
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Trp Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ser Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Gly Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Ala Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Thr Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 715
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 715
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacatctg acgctactta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgggat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 716
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 716
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Gly Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 717
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 717
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
ttaacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatctggga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgggat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgcaccaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 718
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 718
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Leu Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Trp Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Gly Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Thr Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 719
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 719
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaggc ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 720
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 720
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Gly Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 721
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 721
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
ttaacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaggc ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 722
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 722
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Leu Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Gly Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 723
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 723
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
ttaacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgggat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtgcgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 724
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 724
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Leu Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Gly Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Ala Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 725
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 725
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
ttaacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatctggga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaggc ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 726
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 726
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Leu Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Trp Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Gly Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 727
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 727
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtcgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtagttc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 728
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 728
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Ser Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 729
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 729
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtcgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttctc tgccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 730
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 730
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Leu Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 731
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 731
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtcgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccagaatg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttagct ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 732
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 732
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asn Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Ala Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 733
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 733
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccagaatg aagtaaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 734
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 734
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asn Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 735
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 735
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtcgtcggaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccagaatg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttctc tgccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 736
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 736
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asn Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Leu Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 737
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 737
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtcgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccagaatg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttctc tgccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtagttc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 738
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 738
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asn Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Leu Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Ser Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 739
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 739
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtcgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttagct ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 740
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 740
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Ala Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 741
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 741
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc ggcgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttagct ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg ctggtggtgt ttggccgttc gtttctgttg acggtagttc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 742
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 742
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ala 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Ala Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Ser Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 743
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 743
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtcgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccagaatg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttctc tgccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 744
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 744
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asn Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Leu Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 745
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 745
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg cttttgttcc gtcgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 746
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 746
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 747
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 747
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtcgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttctt atccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtagttc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 748
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 748
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Tyr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Ser Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 749
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 749
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtggtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccagaatg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 750
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 750
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Trp 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asn Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 751
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 751
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtcgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccagaatg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtagttc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 752
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 752
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asn Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Ser Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 753
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 753
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtcgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttctc tgccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtagttc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 754
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 754
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Leu Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Ser Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 755
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 755
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtggtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttctc tgccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtagttc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 756
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 756
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Trp 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Leu Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Ser Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 757
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 757
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtcgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttctc tgccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtcgttc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 758
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 758
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Ser 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Leu Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Arg Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 759
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 759
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gtggtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccagaatg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 760
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 760
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Trp 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asn Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 761
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 761
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
ttaacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 762
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 762
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Leu Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 763
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 763
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc agtaatggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 764
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 764
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ser Asn 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 765
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 765
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcgtcgggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctactgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 766
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 766
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ser 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 767
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 767
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt taccattcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 768
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 768
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr His Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 769
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 769
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatgttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 770
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 770
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Met Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 771
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 771
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatcc tgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 772
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 772
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Leu Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 773
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 773
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggttc ggctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 774
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 774
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Ser Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 775
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 775
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
aaggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 776
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 776
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Lys Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 777
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 777
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttccggcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 778
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 778
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Arg Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 779
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 779
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
ctgcaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 780
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 780
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Leu Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 781
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 781
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
accagggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctgtcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 782
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 782
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Arg Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Val Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 783
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 783
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
aggcaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 784
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 784
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Arg Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 785
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 785
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttgtgga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 786
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 786
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Val Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 787
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 787
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttactga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc ggggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 788
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 788
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Thr Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gly Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 789
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 789
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaagt tatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 790
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 790
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Val Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 791
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 791
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgac gccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 792
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 792
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Thr Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 793
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 793
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgctgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 794
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 794
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Leu Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 795
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 795
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagtttcgga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 796
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 796
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Ser Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 797
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 797
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggtgg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 798
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 798
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Val Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 799
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 799
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gacggctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 800
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 800
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Thr Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 801
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 801
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttctgga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 802
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 802
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Leu Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 803
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 803
atggcattct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccatgacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 804
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 804
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr His Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 805
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 805
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tccgtcgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 806
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 806
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Arg Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 807
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 807
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttcttgaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 808
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 808
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Leu Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 809
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 809
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
ggtcaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 810
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 810
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Gly Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 811
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 811
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
ttgaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 812
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 812
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Leu Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 813
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 813
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgtgggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 814
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 814
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Val Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 815
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 815
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
aatcgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 816
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 816
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asn Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 817
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 817
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaaccatgg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 818
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 818
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr Met Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 819
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 819
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacata ttccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 820
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 820
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Ile 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 821
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 821
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
gcgaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 822
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 822
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Ala Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 823
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 823
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgccgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga attgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacgtc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 824
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 824
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Val Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 825
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 825
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tgagctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 826
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 826
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val Glu Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 827
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 827
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtcttggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 828
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 828
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Leu Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 829
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 829
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatg atccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 830
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 830
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Asp 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 831
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 831
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgactt gctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcag 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 832
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 832
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Leu Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly Gln Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 833
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 833
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctcggtc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 834
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 834
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Arg 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 835
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 835
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gtcgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccgact gaactgcgtg atgctgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 836
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 836
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Thr Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 837
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 837
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctgccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtctttc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 838
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 838
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Ala Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Leu Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 839
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 839
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctgttc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 840
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 840
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Val Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 841
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 841
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc cagcgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 842
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 842
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Gln Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 843
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 843
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaactatgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 844
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 844
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Tyr Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 845
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 845
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccg tgtacagtac                                  990

 
<210> 846
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 846
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Arg Val Gln Tyr                         
                325                 330                         

 
<210> 847
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 847
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagactatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 848
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 848
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Thr Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 849
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 849
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtactgttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 850
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 850
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Thr Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 851
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 851
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gccgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttctaatc tgctgacccc ggtacagtac                                  990

 
<210> 852
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 852
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Asn Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 853
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 853
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccaatgga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt 840
tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttgcc tgctgacccc ggtacagtac                                  990

 
<210> 854
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223>  Engineered variant of Arthrobacter transaminase
 
<400> 854
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Met Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         



