                         SEQUENCE LISTING

<110>  WEISLEDER, Noah
 
<120>  Compositions comprising MG53 and methods for the treatment and prevention of airway injury

<130>  115442.00033

<140>  TBD
<141>  2012-09-04

<150>  61/531,708
<151>  2011-09-07

<160>  25    

<170>  PatentIn version 3.4

<210>  1
<211>  477
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(477)
<223>  Human MG53 Polypeptide

<400>  1

Met Ser Ala Ala Pro Gly Leu Leu His Gln Glu Leu Ser Cys Pro Leu 
1               5                   10                  15      


Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 
            20                  25                  30          


Phe Cys Arg Ala Cys Leu Gly Arg Val Ala Gly Glu Pro Ala Ala Asp 
        35                  40                  45              


Gly Thr Val Leu Cys Pro Cys Cys Gln Ala Pro Thr Arg Pro Gln Ala 
    50                  55                  60                  


Leu Ser Thr Asn Leu Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 
65                  70                  75                  80  


Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 
                85                  90                  95      


Cys Glu Gln Asp Arg Ala Leu Val Cys Gly Val Cys Ala Ser Leu Gly 
            100                 105                 110         


Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg 
        115                 120                 125             


Leu Lys Thr Gln Leu Pro Gln Gln Lys Leu Gln Leu Gln Glu Ala Cys 
    130                 135                 140                 


Met Arg Lys Glu Lys Ser Val Ala Val Leu Glu His Gln Leu Val Glu 
145                 150                 155                 160 


Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 
                165                 170                 175     


Gly Lys Met Arg Val Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Cys 
            180                 185                 190         


Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 
        195                 200                 205             


Leu Gly Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 
    210                 215                 220                 


Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 
225                 230                 235                 240 


Tyr Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ser Pro 
                245                 250                 255     


Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser Asp Asp Phe 
            260                 265                 270         


Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro Ala Leu 
        275                 280                 285             


Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Val 
    290                 295                 300                 


Ser Ser Ser Gly Arg Arg Val Glu Cys Ser Glu Gln Lys Ala Pro Pro 
305                 310                 315                 320 


Ala Gly Glu Asp Pro Arg Gln Phe Asp Lys Ala Val Ala Val Val Ala 
                325                 330                 335     


His Gln Gln Leu Ser Glu Gly Glu His Tyr Trp Glu Val Asp Val Gly 
            340                 345                 350         


Asp Lys Pro Arg Trp Ala Leu Gly Val Ile Ala Ala Glu Ala Pro Arg 
        355                 360                 365             


Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 
    370                 375                 380                 


Leu Arg Glu Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 
385                 390                 395                 400 


Arg Ala Leu Arg Ser Pro Glu Arg Arg Pro Thr Arg Ile Gly Leu Tyr 
                405                 410                 415     


Leu Ser Phe Gly Asp Gly Val Leu Ser Phe Tyr Asp Ala Ser Asp Ala 
            420                 425                 430         


Asp Ala Leu Val Pro Leu Phe Ala Phe His Glu Arg Leu Pro Arg Pro 
        435                 440                 445             


Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 
    450                 455                 460                 


Gln Pro Leu Leu Leu Val Gly Pro Glu Gly Ala Glu Ala 
465                 470                 475         


<210>  2
<211>  1434
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1434)
<223>  Human MG53 cDNA

<400>  2
atgtcggctg cgcccggcct cctgcaccag gagctgtcct gcccgctgtg cctgcagctg     60

ttcgacgcgc ccgtgacagc cgagtgcggc cacagtttct gccgcgcctg cctaggccgc    120

gtggccgggg agccggcggc ggatggcacc gttctctgcc cctgctgcca ggcccccacg    180

cggccgcagg cactcagcac caacctgcag ctggcgcgcc tggtggaggg gctggcccag    240

gtgccgcagg gccactgcga ggagcacctg gacccgctga gcatctactg cgagcaggac    300

cgcgcgctgg tgtgcggagt gtgcgcctca ctcggctcgc accgcggtca tcgcctcctg    360

cctgccgccg aggcccacgc acgcctcaag acacagctgc cacagcagaa actgcagctg    420

caggaggcat gcatgcgtaa ggagaagagt gtggctgtgc tggagcatca gctggtggag    480

gtggaggaga cagtgcgtca gttccggggg gccgtggggg agcagctggg caagatgcgg    540

gtgttcctgg ctgcactgga gggctccttg gactgcgagg cagagcgtgt acggggtgag    600

gcaggggtcg ccttgcgccg ggagctgggg agcctgaact cttacctgga gcagctgcgg    660

cagatggaga aggtcctgga ggaggtggcg gacaagccgc agactgagtt cctcatgaaa    720

tactgcctgg tgaccagcag gctgcagaag atcctggcag agtctccccc acccgcccgt    780

ctggacatcc agctgccaat tatctcagat gacttcaaat tccaggtgtg gaggaagatg    840

ttccgggctc tgatgccagc gctggaggag ctgacctttg acccgagctc tgcgcacccg    900

agcctggtgg tgtcttcctc tggccgccgc gtggagtgct cggagcagaa ggcgccgccg    960

gccggggagg acccgcgcca gttcgacaag gcggtggcgg tggtggcgca ccagcagctc   1020

tccgagggcg agcactactg ggaggtggat gttggcgaca agccgcgctg ggcgctgggc   1080

gtgatcgcgg ccgaggcccc ccgccgcggg cgcctgcacg cggtgccctc gcagggcctg   1140

tggctgctgg ggctgcgcga gggcaagatc ctggaggcac acgtggaggc caaggagccg   1200

cgcgctctgc gcagccccga gaggcggccc acgcgcattg gcctttacct gagcttcggc   1260

gacggcgtcc tctccttcta cgatgccagc gacgccgacg cgctcgtgcc gctttttgcc   1320

ttccacgagc gcctgcccag gcccgtgtac cccttcttcg acgtgtgctg gcacgacaag   1380

ggcaagaatg cccagccgct gctgctcgtg ggtcccgaag gcgccgaggc ctga         1434


<210>  3
<211>  477
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(477)
<223>  Mouse MG53

<400>  3

Met Ser Ala Ala Pro Gly Leu Leu Arg Gln Glu Leu Ser Cys Pro Leu 
1               5                   10                  15      


Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 
            20                  25                  30          


Phe Cys Arg Ala Cys Leu Ile Arg Val Ala Gly Glu Pro Ala Ala Asp 
        35                  40                  45              


Gly Thr Val Ala Cys Pro Cys Cys Gln Ala Pro Thr Arg Pro Gln Ala 
    50                  55                  60                  


Leu Ser Thr Asn Leu Gln Leu Ser Arg Leu Val Glu Gly Leu Ala Gln 
65                  70                  75                  80  


Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 
                85                  90                  95      


Cys Glu Gln Asp Arg Thr Leu Val Cys Gly Val Cys Ala Ser Leu Gly 
            100                 105                 110         


Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala Gln Ala Arg 
        115                 120                 125             


Leu Lys Thr Gln Leu Pro Gln Gln Lys Met Gln Leu Gln Glu Ala Cys 
    130                 135                 140                 


Met Arg Lys Glu Lys Thr Val Ala Val Leu Glu His Gln Leu Val Glu 
145                 150                 155                 160 


Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 
                165                 170                 175     


Gly Lys Met Arg Met Phe Leu Ala Ala Leu Glu Ser Ser Leu Asp Arg 
            180                 185                 190         


Glu Ala Glu Arg Val Arg Gly Asp Ala Gly Val Ala Leu Arg Arg Glu 
        195                 200                 205             


Leu Ser Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 
    210                 215                 220                 


Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 
225                 230                 235                 240 


Phe Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ser Glu Ser Pro 
                245                 250                 255     


Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Val Ile Ser Asp Asp Phe 
            260                 265                 270         


Lys Phe Gln Val Trp Lys Lys Met Phe Arg Ala Leu Met Pro Ala Leu 
        275                 280                 285             


Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Val 
    290                 295                 300                 


Ser Ser Ser Gly Arg Arg Val Glu Cys Ser Asp Gln Lys Ala Pro Pro 
305                 310                 315                 320 


Ala Gly Glu Asp Thr Arg Gln Phe Asp Lys Ala Val Ala Val Val Ala 
                325                 330                 335     


Gln Gln Leu Leu Ser Gln Gly Glu His Tyr Trp Glu Val Glu Val Gly 
            340                 345                 350         


Asp Lys Pro Arg Trp Ala Leu Gly Val Met Ala Ala Asp Ala Ser Arg 
        355                 360                 365             


Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 
    370                 375                 380                 


Leu Arg Asp Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 
385                 390                 395                 400 


Arg Ala Leu Arg Thr Pro Glu Arg Pro Pro Ala Arg Ile Gly Leu Tyr 
                405                 410                 415     


Leu Ser Phe Ala Asp Gly Val Leu Ala Phe Tyr Asp Ala Ser Asn Pro 
            420                 425                 430         


Asp Val Leu Thr Pro Ile Phe Ser Phe His Glu Arg Leu Pro Gly Pro 
        435                 440                 445             


Val Tyr Pro Ile Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 
    450                 455                 460                 


Gln Pro Leu Leu Leu Val Gly Pro Glu Gln Glu Gln Ala 
465                 470                 475         


<210>  4
<211>  1434
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(1434)
<223>  Mouse MG53 cDNA

<400>  4
atgtcggctg cacccggcct tctgcgtcag gaactgtcct gcccactgtg cttgcagctg     60

ttcgatgcgc cagtgacggc tgagtgtggc cacagtttct gccgtgcctg cctgatccgg    120

gtggcagggg agcctgctgc ggacggcaca gttgcctgtc cctgttgtca ggcacctaca    180

cggccgcagg ctctaagcac taacctccag ttgtcacgcc ttgtggaggg tttggcgcaa    240

gtgccccaag gccactgcga ggaacacctg gatccactga gcatctactg cgagcaggac    300

cgcacacttg tgtgtggtgt gtgtgcctcg ctcggttctc accgtggtca tcgtctcctg    360

cctgccgctg aagcccaagc acgcctcaag acacagcttc cacagcagaa gatgcagctg    420

caggaggcat gcatgcgcaa ggagaagact gtagcggtgc tggagcatca gctggtggag    480

gtggaggaga cagtgcgcca gttccgggga gctgtcgggg agcagctggg gaagatgcgg    540

atgttcctgg ctgccctaga aagttctctg gaccgtgaag cagaaagggt tcggggtgat    600

gctggggttg ccttgcgtcg ggagctgtca agcctgaact cttacctaga gcaactgagg    660

cagatggaga aggtgctgga ggaggtggct gacaagccac agacagaatt cctcatgaaa    720

ttctgcctgg taaccagcag gctgcagaag atcctgtcag agtcaccacc accggcaagg    780

ctagatatcc agctgcctgt catctcagat gacttcaaat tccaggtgtg gaagaagatg    840

ttccgggctc tgatgccagc gctggaggaa ctgacttttg accccagctc tgcgcacccg    900

agcctggtgg tgtcctcctc tggtcgccga gtggagtgct cagaccagaa ggcgccgcca    960

gcgggagaag acacgcgtca gttcgacaag gcagtagcgg tggtggcgca gcagctgctg   1020

tcacagggcg agcactattg ggaggtggag gtgggcgaca aaccacgctg ggccctggga   1080

gtgatggcgg ctgacgcttc ccgccgtggc cggctgcacg cggtgccctc acaggggctg   1140

tggctgctgg gtctgcgcga tggcaagatc ctggaggcgc acgtggaggc caaggagccg   1200

cgggcactgc gcaccccaga gaggcctccg gcgcgcattg gcctctacct aagcttcgca   1260

gatggcgtcc tggctttcta tgatgcgagc aaccccgacg tacttacgcc aatcttttct   1320

ttccacgagc gtctgcccgg gccggtgtac cccatctttg acgtgtgctg gcacgacaag   1380

ggcaagaatg cccagcccct gctgcttgtg gggccggagc aggaacaggc ctga         1434


<210>  5
<211>  477
<212>  PRT
<213>  Oryctolagus cuniculus


<220>
<221>  misc_feature
<222>  (1)..(477)
<223>  Rabbit MG53

<400>  5

Met Ser Ala Ala Pro Gly Leu Leu His Gln Glu Leu Ser Cys Pro Leu 
1               5                   10                  15      


Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 
            20                  25                  30          


Phe Cys Arg Ala Cys Leu Ser Arg Val Ala Gly Glu Pro Ala Ala Asp 
        35                  40                  45              


Gly Thr Val Asn Cys Pro Cys Cys Gln Ala Pro Thr Arg Pro Gln Ala 
    50                  55                  60                  


Leu Ser Thr Asn Leu Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 
65                  70                  75                  80  


Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 
                85                  90                  95      


Cys Glu Gln Asp Arg Val Leu Val Cys Gly Val Cys Ala Ser Leu Gly 
            100                 105                 110         


Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ser Arg 
        115                 120                 125             


Leu Lys Thr Gln Leu Pro Gln Gln Lys Leu Gln Leu Gln Glu Ala Ser 
    130                 135                 140                 


Met Arg Lys Glu Lys Ser Val Ala Val Leu Glu His Gln Leu Thr Glu 
145                 150                 155                 160 


Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 
                165                 170                 175     


Gly Lys Met Arg Val Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Arg 
            180                 185                 190         


Glu Ala Glu Arg Val Arg Ser Glu Ala Gly Val Ala Leu Arg Arg Glu 
        195                 200                 205             


Leu Gly Gly Leu His Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 
    210                 215                 220                 


Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 
225                 230                 235                 240 


Tyr Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ser Pro 
                245                 250                 255     


Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser Asp Asp Phe 
            260                 265                 270         


Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro Ala Leu 
        275                 280                 285             


Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Val 
    290                 295                 300                 


Ser Pro Thr Gly Arg Arg Val Glu Cys Ser Glu Gln Lys Ala Pro Pro 
305                 310                 315                 320 


Ala Gly Asp Asp Ala Arg Gln Phe Asp Lys Ala Val Ala Val Val Ala 
                325                 330                 335     


Gln Gln Leu Leu Ser Asp Gly Glu His Tyr Trp Glu Val Glu Val Gly 
            340                 345                 350         


Asp Lys Pro Arg Trp Ala Leu Gly Val Met Ala Ser Glu Ala Ser Arg 
        355                 360                 365             


Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 
    370                 375                 380                 


Leu Arg Asp Gly Lys Thr Leu Glu Ala His Val Glu Ala Lys Glu Pro 
385                 390                 395                 400 


Arg Ala Leu Arg Thr Pro Glu Arg Arg Pro Thr Arg Leu Gly Leu Tyr 
                405                 410                 415     


Leu Ser Phe Gly Asp Gly Val Leu Ala Phe Tyr Asp Ala Ser Asp Ala 
            420                 425                 430         


Asp Ala Leu Glu Leu Leu Phe Ala Phe Arg Glu Arg Leu Pro Gly Pro 
        435                 440                 445             


Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 
    450                 455                 460                 


Gln Pro Leu Leu Leu Val Gly Pro Asp Gly Gln Glu Ala 
465                 470                 475         


<210>  6
<211>  1434
<212>  DNA
<213>  Oryctolagus cuniculus


<220>
<221>  misc_feature
<222>  (1)..(1434)
<223>  Rabbit MG53 cDNA

<400>  6
atgtcggccg cgcccggcct cctgcaccag gagctgtctt gcccgctgtg cctgcagctg     60

ttcgacgcgc ccgtgacagc cgagtgcggc cacagtttct gccgcgcctg cctgagccgc    120

gtggcggggg agccggcggc cgatggcacc gtgaactgcc cgtgctgcca ggcgcccacg    180

cggccgcagg cgctcagcac caacctgcag ctggcgcgcc tggtggaggg gctggcgcag    240

gtgccgcagg gccactgcga ggagcacctg gacccgctga gcatctactg cgagcaggac    300

cgcgttctcg tgtgcggcgt gtgcgcctcg ctcggctcgc accgcggcca ccgcctgctg    360

cccgccgccg aggcccactc gcgtctcaag acgcagctgc cccagcagaa gctgcagctg    420

caggaggcga gcatgcgcaa ggagaagagc gtggccgtgc tggagcacca gctcacggag    480

gtggaggaga cagtgcgtca gttccggggg gcagtggggg agcagctggg caagatgcgg    540

gtgttcctgg ccgccctgga gggctccctg gaccgcgagg cagaacgtgt gcggagcgag    600

gcgggggtgg ccttgcggcg ggagctgggg ggcctccact cgtacctgga gcagctgcgg    660

cagatggaga aggtgttgga ggaggtggct gacaagccac agaccgagtt ccttatgaaa    720

tattgcctgg tgaccagcag gctgcagaag atcctggcgg agtcgccacc acctgctcgt    780

ctggacatcc agctgcccat catttcagat gacttcaaat tccaggtgtg gaggaagatg    840

ttccgggctc tgatgccagc gctggaggag ctgacctttg acccgagctc cgcgcacccg    900

agcctcgtgg tgtcacccac gggccgccga gtggagtgct cggagcagaa ggcgccgccc    960

gccggggacg acgcgcgcca gttcgacaag gctgtggccg tggtggcgca gcagctgctg   1020

tccgacggcg agcactactg ggaggtggag gtgggcgaca agccgcgctg ggcgctgggc   1080

gtgatggcct ccgaggcgag ccgccgtggc cggctgcacg ccgtgccctc acagggtttg   1140

tggctgctgg ggctgcgcga cggcaagacc ctggaggcgc acgtggaggc caaggagccg   1200

cgcgcgctgc gcaccccgga gcggcggccc acgcgcctcg gcctctacct cagcttcggc   1260

gatggcgtgc tcgccttcta cgacgccagc gacgccgacg cgctcgagct gctgtttgct   1320

ttccgcgagc gcctgcccgg gcccgtgtac cccttcttcg acgtgtgctg gcatgacaag   1380

ggcaagaatg cgcagccgct gctgctcgtg gggccggatg gccaggaggc ctga         1434


<210>  7
<211>  477
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MUTAGEN
<222>  (29)..(29)
<223>  C29L/C242A

<220>
<221>  MUTAGEN
<222>  (242)..(242)
<223>  C29L/C242A

<400>  7

Met Ser Ala Ala Pro Gly Leu Leu His Gln Glu Leu Ser Cys Pro Leu 
1               5                   10                  15      


Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Leu Gly His Ser 
            20                  25                  30          


Phe Cys Arg Ala Cys Leu Gly Arg Val Ala Gly Glu Pro Ala Ala Asp 
        35                  40                  45              


Gly Thr Val Leu Cys Pro Cys Cys Gln Ala Pro Thr Arg Pro Gln Ala 
    50                  55                  60                  


Leu Ser Thr Asn Leu Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 
65                  70                  75                  80  


Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 
                85                  90                  95      


Cys Glu Gln Asp Arg Ala Leu Val Cys Gly Val Cys Ala Ser Leu Gly 
            100                 105                 110         


Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg 
        115                 120                 125             


Leu Lys Thr Gln Leu Pro Gln Gln Lys Leu Gln Leu Gln Glu Ala Cys 
    130                 135                 140                 


Met Arg Lys Glu Lys Ser Val Ala Val Leu Glu His Gln Leu Val Glu 
145                 150                 155                 160 


Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 
                165                 170                 175     


Gly Lys Met Arg Val Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Cys 
            180                 185                 190         


Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 
        195                 200                 205             


Leu Gly Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 
    210                 215                 220                 


Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 
225                 230                 235                 240 


Tyr Ala Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ser Pro 
                245                 250                 255     


Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser Asp Asp Phe 
            260                 265                 270         


Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro Ala Leu 
        275                 280                 285             


Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Val 
    290                 295                 300                 


Ser Ser Ser Gly Arg Arg Val Glu Cys Ser Glu Gln Lys Ala Pro Pro 
305                 310                 315                 320 


Ala Gly Glu Asp Pro Arg Gln Phe Asp Lys Ala Val Ala Val Val Ala 
                325                 330                 335     


His Gln Gln Leu Ser Glu Gly Glu His Tyr Trp Glu Val Asp Val Gly 
            340                 345                 350         


Asp Lys Pro Arg Trp Ala Leu Gly Val Ile Ala Ala Glu Ala Pro Arg 
        355                 360                 365             


Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 
    370                 375                 380                 


Leu Arg Glu Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 
385                 390                 395                 400 


Arg Ala Leu Arg Ser Pro Glu Arg Arg Pro Thr Arg Ile Gly Leu Tyr 
                405                 410                 415     


Leu Ser Phe Gly Asp Gly Val Leu Ser Phe Tyr Asp Ala Ser Asp Ala 
            420                 425                 430         


Asp Ala Leu Val Pro Leu Phe Ala Phe His Glu Arg Leu Pro Arg Pro 
        435                 440                 445             


Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 
    450                 455                 460                 


Gln Pro Leu Leu Leu Val Gly Pro Glu Gly Ala Glu Ala 
465                 470                 475         


<210>  8
<211>  151
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(151)
<223>  P56539 CAV3_HUMAN CAVEOLIN-3 - HOMO SAPIENS (HUMAN).

<400>  8

Met Met Ala Glu Glu His Thr Asp Leu Glu Ala Gln Ile Val Lys Asp 
1               5                   10                  15      


Ile His Cys Lys Glu Ile Asp Leu Val Asn Arg Asp Pro Lys Asn Ile 
            20                  25                  30          


Asn Glu Asp Ile Val Lys Val Asp Phe Glu Asp Val Ile Ala Glu Pro 
        35                  40                  45              


Val Gly Thr Tyr Ser Phe Asp Gly Val Trp Lys Val Ser Tyr Thr Thr 
    50                  55                  60                  


Phe Thr Val Ser Lys Tyr Trp Cys Tyr Arg Leu Leu Ser Thr Leu Leu 
65                  70                  75                  80  


Gly Val Pro Leu Ala Leu Leu Trp Gly Phe Leu Phe Ala Cys Ile Ser 
                85                  90                  95      


Phe Cys His Ile Trp Ala Val Val Pro Cys Ile Lys Ser Tyr Leu Ile 
            100                 105                 110         


Glu Ile Gln Cys Ile Ser His Ile Tyr Ser Leu Cys Ile Arg Thr Phe 
        115                 120                 125             


Cys Asn Pro Leu Phe Ala Ala Leu Gly Gln Val Cys Ser Ser Ile Lys 
    130                 135                 140                 


Val Val Leu Arg Lys Glu Val 
145                 150     


<210>  9
<211>  477
<212>  PRT
<213>  Didelphis sp.


<220>
<221>  PEPTIDE
<222>  (1)..(477)
<223>  Opossum MG53

<400>  9

Met Ser Gly Ala Pro Ala Leu Met Gln Gly Met Tyr Gln Asp Leu Ser 
1               5                   10                  15      


Cys Pro Leu Cys Leu Lys Leu Phe Asp Ala Pro Ile Thr Ala Glu Cys 
            20                  25                  30          


Gly His Ser Phe Cys Arg Asn Cys Leu Leu Arg Leu Ala Pro Asp Pro 
        35                  40                  45              


Gln Ala Gly Thr Val Leu Cys Pro Ser Cys Gln Ala Pro Thr Lys Pro 
    50                  55                  60                  


Asp Gly Leu Asn Thr Asn Gln Gln Leu Ala Arg Leu Val Glu Ser Leu 
65                  70                  75                  80  


Ala Gln Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser 
                85                  90                  95      


Val Tyr Cys Glu Gln Asp Arg Ala Leu Ile Cys Gly Val Cys Ala Ser 
            100                 105                 110         


Leu Gly Lys His Arg Gly His Ser Val Val Thr Ala Ala Glu Ala His 
        115                 120                 125             


Gln Arg Met Lys Lys Gln Leu Pro Gln Gln Arg Leu Gln Leu Gln Glu 
    130                 135                 140                 


Ala Cys Met Arg Lys Glu Lys Thr Val Ala Leu Leu Asp Arg Gln Leu 
145                 150                 155                 160 


Ala Glu Val Glu Glu Thr Val Arg Gln Phe Gln Arg Ala Val Gly Glu 
                165                 170                 175     


Gln Leu Gly Val Met Arg Ala Phe Leu Ala Ala Leu Glu Ser Ser Leu 
            180                 185                 190         


Gly Lys Glu Ala Glu Arg Val Thr Gly Glu Ala Gly Thr Ala Leu Lys 
        195                 200                 205             


Ala Glu Arg Arg Ile Val Thr Ser Tyr Leu Asp Gln Leu Gln Gln Met 
    210                 215                 220                 


Glu Lys Val Leu Asp Glu Val Thr Asp Gln Pro Gln Thr Glu Phe Leu 
225                 230                 235                 240 


Arg Lys Tyr Cys Leu Val Ile Ser Arg Leu Gln Lys Ile Leu Ala Glu 
                245                 250                 255     


Ser Pro Pro Ala Ala Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser Asp 
            260                 265                 270         


Asp Phe Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro 
        275                 280                 285             


Gly Met Glu Val Leu Thr Phe Asp Pro Ala Ser Ala His Pro Ser Leu 
    290                 295                 300                 


Leu Val Ser Pro Ser Gly Arg Arg Val Glu Cys Val Glu Gln Lys Ala 
305                 310                 315                 320 


Pro Pro Ala Gly Asp Asp Pro Gln Gln Phe Asp Lys Ala Val Ala Leu 
                325                 330                 335     


Val Ala Lys Gln Gln Leu Ser Glu Gly Glu His Tyr Trp Glu Val Glu 
            340                 345                 350         


Val Gly Asp Lys Pro Arg Trp Gly Leu Gly Leu Ile Ser Ala Asp Val 
        355                 360                 365             


Ser Arg Arg Gly Lys Leu His Pro Thr Pro Ser Gln Gly Phe Trp Met 
    370                 375                 380                 


Leu Gly Leu Arg Glu Gly Lys Val Tyr Glu Ala His Val Glu Ser Lys 
385                 390                 395                 400 


Glu Pro Lys Val Leu Lys Val Asp Gly Arg Pro Ser Arg Ile Gly Leu 
                405                 410                 415     


Tyr Leu Ser Phe Arg Asp Gly Val Leu Ser Phe Tyr Asp Ala Ser Asp 
            420                 425                 430         


Leu Asp Asn Leu Leu Pro Leu Tyr Ala Phe His Glu Arg Leu Pro Gly 
        435                 440                 445             


Pro Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn 
    450                 455                 460                 


Ala Gln Pro Leu Leu Leu Leu Gly Pro Asp Gly Glu Gln 
465                 470                 475         


<210>  10
<211>  477
<212>  PRT
<213>  Canis sp.


<220>
<221>  PEPTIDE
<222>  (1)..(477)
<223>  Dog MG53

<400>  10

Met Ser Ala Ala Pro Gly Leu Leu His Gln Glu Leu Ser Cys Pro Leu 
1               5                   10                  15      


Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 
            20                  25                  30          


Phe Cys Arg Ala Cys Leu Ser Arg Val Ala Gly Glu Pro Ala Ala Asp 
        35                  40                  45              


Gly Thr Val Pro Cys Pro Cys Cys Gln Ala Leu Thr Arg Pro Gln Ala 
    50                  55                  60                  


Leu Ser Thr Asn Gln Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 
65                  70                  75                  80  


Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 
                85                  90                  95      


Cys Glu Gln Asp Arg Ala Leu Val Cys Gly Val Cys Ala Ser Leu Gly 
            100                 105                 110         


Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg 
        115                 120                 125             


Leu Lys Thr Gln Leu Pro Gln Gln Lys Leu Gln Leu Gln Glu Ala Cys 
    130                 135                 140                 


Met Arg Lys Glu Lys Ser Val Ala Leu Leu Glu His Gln Leu Met Glu 
145                 150                 155                 160 


Val Glu Glu Met Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 
                165                 170                 175     


Gly Lys Met Arg Val Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Arg 
            180                 185                 190         


Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 
        195                 200                 205             


Leu Gly Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 
    210                 215                 220                 


Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 
225                 230                 235                 240 


Tyr Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ser Pro 
                245                 250                 255     


Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Val Ile Ser Asp Asp Phe 
            260                 265                 270         


Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro Val Thr 
        275                 280                 285             


Lys Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Leu 
    290                 295                 300                 


Ser Pro Ser Gly Arg Arg Val Glu Cys Ser Asp Gln Lys Ala Pro Pro 
305                 310                 315                 320 


Ala Gly Glu Asp Pro Cys Gln Phe Asp Lys Ala Val Ala Val Val Ala 
                325                 330                 335     


Gln Gln Val Leu Ser Asp Gly Glu His Tyr Trp Glu Val Gln Val Gly 
            340                 345                 350         


Glu Lys Pro Arg Trp Ala Leu Gly Val Ile Ala Ala Gln Ala Ser Arg 
        355                 360                 365             


Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 
    370                 375                 380                 


Leu Arg Asp Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 
385                 390                 395                 400 


Arg Ala Leu Arg Thr Pro Glu Arg Arg Pro Thr Arg Ile Gly Ile Tyr 
                405                 410                 415     


Leu Ser Phe Gly Asp Gly Val Leu Ser Phe Tyr Asp Ala Ser Asp Pro 
            420                 425                 430         


Asp Ala Leu Glu Leu Leu Phe Ala Phe His Glu Arg Leu Pro Gly Pro 
        435                 440                 445             


Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 
    450                 455                 460                 


Gln Pro Leu Leu Leu Val Gly Pro Asp Gly Glu Glu Ala 
465                 470                 475         


<210>  11
<211>  477
<212>  PRT
<213>  Pan troglodytes


<220>
<221>  PEPTIDE
<222>  (1)..(477)
<223>  Chimpanzee MG53

<400>  11

Met Ser Ala Ala Pro Gly Leu Leu His Gln Glu Leu Ser Cys Pro Leu 
1               5                   10                  15      


Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 
            20                  25                  30          


Phe Cys Arg Ala Cys Leu Gly Arg Val Ala Gly Glu Pro Ala Ala Asp 
        35                  40                  45              


Gly Thr Val Leu Cys Pro Cys Cys Gln Ala Pro Thr Arg Pro Gln Ala 
    50                  55                  60                  


Leu Ser Thr Asn Leu Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 
65                  70                  75                  80  


Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 
                85                  90                  95      


Cys Glu Gln Asp Arg Ala Leu Val Cys Gly Val Cys Ala Ser Leu Gly 
            100                 105                 110         


Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg 
        115                 120                 125             


Leu Lys Thr Gln Leu Pro Gln Gln Lys Leu Gln Leu Gln Glu Ala Cys 
    130                 135                 140                 


Met Arg Lys Glu Lys Ser Val Ala Val Leu Glu His Gln Leu Val Glu 
145                 150                 155                 160 


Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 
                165                 170                 175     


Gly Lys Met Arg Val Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Arg 
            180                 185                 190         


Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 
        195                 200                 205             


Leu Gly Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 
    210                 215                 220                 


Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 
225                 230                 235                 240 


Tyr Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ser Pro 
                245                 250                 255     


Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser Asp Asp Phe 
            260                 265                 270         


Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro Ala Leu 
        275                 280                 285             


Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Val 
    290                 295                 300                 


Ser Ser Ser Gly Arg Arg Val Glu Cys Ser Glu Gln Lys Ala Pro Pro 
305                 310                 315                 320 


Ala Gly Glu Asp Pro Arg Gln Phe Asp Lys Ala Val Ala Val Val Ala 
                325                 330                 335     


His Gln Gln Leu Ser Glu Gly Glu His Tyr Trp Glu Val Asp Val Gly 
            340                 345                 350         


Asp Lys Pro Arg Trp Ala Leu Gly Val Ile Ala Ala Glu Ala Pro Arg 
        355                 360                 365             


Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 
    370                 375                 380                 


Leu Arg Glu Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 
385                 390                 395                 400 


Arg Ala Leu Arg Ser Pro Glu Arg Arg Pro Thr Arg Ile Gly Leu Tyr 
                405                 410                 415     


Leu Ser Phe Gly Asp Gly Val Leu Ser Phe Tyr Asp Ala Ser Asp Ala 
            420                 425                 430         


Asp Ala Leu Val Pro Leu Phe Ala Phe His Glu Arg Leu Pro Arg Pro 
        435                 440                 445             


Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 
    450                 455                 460                 


Gln Pro Leu Leu Leu Val Gly Pro Glu Gly Ala Glu Ala 
465                 470                 475         


<210>  12
<211>  477
<212>  PRT
<213>  Macaca mulatta


<220>
<221>  PEPTIDE
<222>  (1)..(477)
<223>  Rhesus Monkey MG53

<400>  12

Met Ser Ala Ala Pro Gly Leu Leu His Gln Glu Leu Ser Cys Pro Leu 
1               5                   10                  15      


Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 
            20                  25                  30          


Phe Cys Arg Ala Cys Leu Gly Arg Val Ala Gly Glu Pro Ala Ala Asp 
        35                  40                  45              


Gly Thr Val Leu Cys Pro Cys Cys Gln Ala Pro Thr Arg Pro Gln Ala 
    50                  55                  60                  


Leu Ser Thr Asn Leu Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 
65                  70                  75                  80  


Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 
                85                  90                  95      


Cys Glu Gln Asp Arg Ala Leu Val Cys Gly Val Cys Ala Ser Leu Gly 
            100                 105                 110         


Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg 
        115                 120                 125             


Leu Lys Thr Gln Leu Pro Gln Gln Lys Leu Gln Leu Gln Glu Ala Cys 
    130                 135                 140                 


Met Arg Lys Glu Lys Ser Val Ala Val Leu Glu His Gln Leu Val Glu 
145                 150                 155                 160 


Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 
                165                 170                 175     


Gly Lys Met Arg Val Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Arg 
            180                 185                 190         


Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 
        195                 200                 205             


Leu Gly Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 
    210                 215                 220                 


Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 
225                 230                 235                 240 


Tyr Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ser Pro 
                245                 250                 255     


Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser Asp Asp Phe 
            260                 265                 270         


Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro Ala Leu 
        275                 280                 285             


Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Val 
    290                 295                 300                 


Ser Ser Ser Gly Arg Arg Val Glu Cys Ser Glu Gln Lys Ala Pro Pro 
305                 310                 315                 320 


Ala Gly Glu Asp Pro Arg Gln Phe Asp Lys Ala Val Ala Val Val Ala 
                325                 330                 335     


His Gln Gln Leu Ser Glu Gly Glu His Tyr Trp Glu Val Glu Val Gly 
            340                 345                 350         


Asp Lys Pro Arg Trp Ala Leu Gly Val Ile Ala Ala Glu Gly Pro Arg 
        355                 360                 365             


Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 
    370                 375                 380                 


Leu Arg Glu Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 
385                 390                 395                 400 


Arg Ala Leu Arg Ser Pro Glu Arg Arg Pro Thr Arg Ile Gly Leu Tyr 
                405                 410                 415     


Leu Ser Phe Gly Asp Gly Val Leu Ser Phe Tyr Asp Ala Ser Asp Ala 
            420                 425                 430         


Asp Ala Leu Val Pro Leu Phe Ala Phe His Glu Arg Leu Pro Gly Pro 
        435                 440                 445             


Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ser 
    450                 455                 460                 


Gln Pro Leu Leu Leu Val Gly Ser Glu Gly Ala Glu Ala 
465                 470                 475         


<210>  13
<211>  482
<212>  PRT
<213>  Bos sp.


<220>
<221>  PEPTIDE
<222>  (1)..(482)
<223>  Bovine MG53

<400>  13

Met Ser Ala Ala Pro Gly Leu Leu His Gln Glu Leu Ser Cys Pro Leu 
1               5                   10                  15      


Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 
            20                  25                  30          


Phe Cys Arg Ala Cys Leu Ser Arg Val Ala Gly Glu Pro Ala Ala Asp 
        35                  40                  45              


Gly Thr Val Leu Cys Pro Ser Cys Gln Ala Pro Thr Arg Pro Gln Ala 
    50                  55                  60                  


Leu Ser Thr Asn Leu Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 
65                  70                  75                  80  


Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 
                85                  90                  95      


Cys Glu Gln Asp Arg Ala Leu Val Cys Gly Val Cys Ala Ser Leu Gly 
            100                 105                 110         


Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg 
        115                 120                 125             


Leu Lys Thr Gln Leu Pro Gln Gln Lys Met Gln Leu Gln Glu Ala Cys 
    130                 135                 140                 


Met Arg Lys Glu Lys Ser Val Ala Leu Leu Glu His Gln Leu Leu Glu 
145                 150                 155                 160 


Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 
                165                 170                 175     


Gly Lys Met Arg Leu Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Arg 
            180                 185                 190         


Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 
        195                 200                 205             


Leu Gly Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 
    210                 215                 220                 


Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 
225                 230                 235                 240 


Tyr Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ser Pro 
                245                 250                 255     


Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser Asp Asp Phe 
            260                 265                 270         


Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro Ala Arg 
        275                 280                 285             


Gln Glu Leu Thr Phe Asp Pro Ser Thr Ala His Pro Ser Leu Val Leu 
    290                 295                 300                 


Ser Asn Ser Gly Arg Cys Val Glu Cys Ser Glu Gln Lys Ala Pro Pro 
305                 310                 315                 320 


Ala Gly Glu Asp Pro Arg Gln Phe Asp Lys Ala Val Ala Val Val Thr 
                325                 330                 335     


His Gln Leu Leu Ser Glu Gly Glu His Tyr Trp Glu Val Glu Val Gly 
            340                 345                 350         


Asp Lys Pro Arg Trp Ala Leu Gly Val Ile Gly Ala Gln Ala Gly Arg 
        355                 360                 365             


Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 
    370                 375                 380                 


Leu Arg Asp Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 
385                 390                 395                 400 


Arg Ala Leu Arg Thr Pro Glu Arg Arg Pro Thr Arg Ile Gly Ile Tyr 
                405                 410                 415     


Leu Ser Phe Gly Asp Gly Val Leu Ser Phe Tyr Asp Ala Ser Asp Pro 
            420                 425                 430         


Asp Ala Leu Glu Leu Leu Phe Ala Phe His Glu Arg Leu Pro Gly Pro 
        435                 440                 445             


Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 
    450                 455                 460                 


Gln Pro Leu Leu Leu Val Gly Pro Glu Val Ser Gly Gly Ser Gly Ser 
465                 470                 475                 480 


Glu Ala 
        


<210>  14
<211>  477
<212>  PRT
<213>  Rattus sp.


<220>
<221>  PEPTIDE
<222>  (1)..(477)
<223>  Rat MG53

<400>  14

Met Ser Thr Ala Pro Gly Leu Leu Arg Gln Glu Leu Ser Cys Pro Leu 
1               5                   10                  15      


Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 
            20                  25                  30          


Phe Cys Arg Ala Cys Leu Ile Arg Val Ala Gly Glu Pro Ala Asp Asp 
        35                  40                  45              


Gly Thr Val Ala Cys Pro Cys Cys Gln Ala Ser Thr Arg Pro Gln Ala 
    50                  55                  60                  


Leu Ser Thr Asn Leu Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 
65                  70                  75                  80  


Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 
                85                  90                  95      


Cys Glu Gln Asp Arg Thr Leu Val Cys Gly Val Cys Ala Ser Leu Gly 
            100                 105                 110         


Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg 
        115                 120                 125             


Leu Lys Thr Gln Leu Pro Gln Gln Lys Ala Gln Leu Gln Glu Ala Cys 
    130                 135                 140                 


Met Arg Lys Glu Lys Ser Val Ala Val Leu Glu His Gln Leu Val Glu 
145                 150                 155                 160 


Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 
                165                 170                 175     


Gly Lys Met Arg Met Phe Leu Ala Ala Leu Glu Ser Ser Leu Asp Arg 
            180                 185                 190         


Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 
        195                 200                 205             


Leu Ser Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 
    210                 215                 220                 


Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 
225                 230                 235                 240 


Phe Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ser Glu Ser Pro 
                245                 250                 255     


Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Val Ile Ser Asp Asp Phe 
            260                 265                 270         


Lys Phe Gln Val Trp Lys Lys Met Phe Arg Ala Leu Met Pro Glu Leu 
        275                 280                 285             


Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Val 
    290                 295                 300                 


Ser Ala Ser Gly Arg Arg Val Glu Cys Ser Glu Gln Lys Ala Pro Pro 
305                 310                 315                 320 


Ala Gly Glu Asp Thr Cys Gln Phe Asp Lys Thr Val Ala Val Val Ala 
                325                 330                 335     


Lys Gln Leu Leu Ser Gln Gly Glu His Tyr Trp Glu Val Glu Val Gly 
            340                 345                 350         


Asp Lys Pro Arg Trp Ala Leu Gly Val Met Ala Ala Asp Ala Ser Arg 
        355                 360                 365             


Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 
    370                 375                 380                 


Leu Arg Asp Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 
385                 390                 395                 400 


Arg Ala Leu Arg Thr Pro Glu Arg Pro Pro Ala Arg Ile Gly Leu Tyr 
                405                 410                 415     


Leu Ser Phe Ala Asp Gly Val Leu Thr Phe Tyr Asp Ala Ser Asn Thr 
            420                 425                 430         


Asp Ala Leu Thr Pro Leu Phe Ser Phe His Glu Arg Leu Pro Gly Pro 
        435                 440                 445             


Val Tyr Pro Met Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ser 
    450                 455                 460                 


Gln Pro Leu Leu Leu Val Gly Pro Asp Ser Glu Gln Ala 
465                 470                 475         


<210>  15
<211>  477
<212>  PRT
<213>  Xenopus laevis


<220>
<221>  PEPTIDE
<222>  (1)..(477)
<223>  Xenopus laevis

<400>  15

Met Ser Thr Pro Gln Leu Met Gln Gly Met Gln Lys Asp Leu Thr Cys 
1               5                   10                  15      


Gln Leu Cys Leu Glu Leu Phe Arg Ala Pro Val Thr Pro Glu Cys Gly 
            20                  25                  30          


His Thr Phe Cys Gln Gly Cys Leu Thr Gly Val Pro Lys Asn Gln Asp 
        35                  40                  45              


Gln Asn Gly Ser Thr Pro Cys Pro Thr Cys Gln Ser Pro Ser Arg Pro 
    50                  55                  60                  


Glu Thr Leu Gln Ile Asn Arg Gln Leu Glu His Leu Val Gln Ser Phe 
65                  70                  75                  80  


Lys Gln Val Pro Gln Gly His Cys Leu Glu His Met Asp Pro Leu Ser 
                85                  90                  95      


Val Tyr Cys Glu Gln Asp Lys Glu Leu Ile Cys Gly Val Cys Ala Ser 
            100                 105                 110         


Leu Gly Lys His Lys Gly His Asn Ile Ile Thr Ala Ser Glu Ala Phe 
        115                 120                 125             


Ala Lys Leu Lys Arg Gln Leu Pro Gln Gln Gln Val Ile Leu Gln Glu 
    130                 135                 140                 


Ala Arg Leu Lys Lys Glu Lys Thr Val Ala Val Leu Asp Arg Gln Val 
145                 150                 155                 160 


Ala Glu Val Gln Asp Thr Val Ser Arg Phe Lys Gly Asn Val Lys His 
                165                 170                 175     


Gln Leu Asn Ala Met Arg Ser Tyr Leu Asn Ile Met Glu Ala Ser Leu 
            180                 185                 190         


Gly Lys Glu Ala Asp Lys Ala Glu Ser Ala Ala Thr Glu Ala Leu Leu 
        195                 200                 205             


Val Glu Arg Lys Thr Met Gly His Tyr Leu Asp Gln Leu Arg Gln Met 
    210                 215                 220                 


Glu Gly Val Leu Lys Asp Val Glu Gly Gln Glu Gln Thr Glu Phe Leu 
225                 230                 235                 240 


Arg Lys Tyr Cys Val Val Ala Ala Arg Leu Asn Lys Ile Leu Ser Glu 
                245                 250                 255     


Ser Pro Pro Pro Gly Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser Asp 
            260                 265                 270         


Glu Phe Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro 
        275                 280                 285             


Ala Leu Glu Asn Met Thr Phe Asp Pro Asp Thr Ala Gln Gln Tyr Leu 
    290                 295                 300                 


Val Val Ser Ser Glu Gly Lys Ser Val Glu Cys Ala Asp Gln Lys Gln 
305                 310                 315                 320 


Ser Val Ser Asp Glu Pro Asn Arg Phe Asp Lys Ser Asn Cys Leu Val 
                325                 330                 335     


Ser Lys Gln Ser Phe Thr Glu Gly Glu His Tyr Trp Glu Val Ile Val 
            340                 345                 350         


Glu Asp Lys Pro Arg Trp Ala Leu Gly Ile Ile Ser Glu Thr Ala Asn 
        355                 360                 365             


Arg Lys Gly Lys Leu His Ala Thr Pro Ser Asn Gly Phe Trp Ile Ile 
    370                 375                 380                 


Gly Cys Lys Glu Gly Lys Val Tyr Glu Ala His Thr Glu Gln Lys Glu 
385                 390                 395                 400 


Pro Arg Val Leu Arg Val Glu Gly Arg Pro Glu Lys Ile Gly Val Tyr 
                405                 410                 415     


Leu Ser Phe Ser Asp Gly Val Val Ser Phe Phe Asp Ser Ser Asp Glu 
            420                 425                 430         


Asp Asn Leu Lys Leu Leu Tyr Thr Phe Asn Glu Arg Phe Ser Gly Arg 
        435                 440                 445             


Leu His Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ser 
    450                 455                 460                 


Gln Pro Leu Lys Ile Phe Tyr Pro Pro Ala Glu Gln Leu 
465                 470                 475         


<210>  16
<211>  477
<212>  PRT
<213>  Xenopus sp.


<220>
<221>  PEPTIDE
<222>  (1)..(477)
<223>  Xenopus tropicalis MG53

<400>  16

Met Ser Thr Pro Gln Leu Met Gln Gly Met Gln Lys Asp Leu Thr Cys 
1               5                   10                  15      


Pro Leu Cys Leu Glu Leu Phe Arg Ala Pro Val Thr Pro Glu Cys Gly 
            20                  25                  30          


His Thr Phe Cys Gln Gly Cys Leu Thr Gly Ala Pro Lys Asn Gln Asp 
        35                  40                  45              


Gln Asn Gly Ser Thr Pro Cys Pro Thr Cys Gln Thr Pro Ser Arg Pro 
    50                  55                  60                  


Glu Thr Leu Gln Ile Asn Arg Gln Leu Glu His Leu Val Gln Ser Phe 
65                  70                  75                  80  


Lys Gln Val Pro Lys Gly His Cys Leu Glu His Leu Asp Pro Leu Ser 
                85                  90                  95      


Val Tyr Cys Glu Gln Asp Lys Glu Leu Ile Cys Gly Val Cys Ala Ser 
            100                 105                 110         


Leu Gly Lys His Lys Gly His Asn Ile Ile Thr Ala Ala Glu Ala Tyr 
        115                 120                 125             


Ala Lys Leu Lys Arg Gln Leu Pro Gln Gln Gln Val Ile Leu Gln Glu 
    130                 135                 140                 


Ala Arg Leu Lys Lys Glu Lys Thr Val Ala Val Leu Asp Arg Gln Val 
145                 150                 155                 160 


Ala Glu Val Gln Asp Thr Val Ser Arg Phe Lys Gly Asn Val Lys His 
                165                 170                 175     


Gln Leu Asn Ala Met Arg Ser Tyr Leu Ser Ile Met Glu Ala Ser Leu 
            180                 185                 190         


Ser Lys Glu Ala Asp Asn Ala Glu His Thr Ala Thr Glu Ala Leu Leu 
        195                 200                 205             


Val Glu Arg Lys Thr Met Gly His Tyr Leu Asp Gln Leu Arg Gln Met 
    210                 215                 220                 


Asp Gly Val Leu Lys Asp Val Glu Ser Gln Glu Gln Thr Glu Phe Leu 
225                 230                 235                 240 


Arg Lys Tyr Cys Val Val Ala Ala Arg Leu Asn Lys Ile Leu Ala Glu 
                245                 250                 255     


Ser Pro Pro Pro Gly Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser Asp 
            260                 265                 270         


Glu Phe Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro 
        275                 280                 285             


Ala Leu Glu Asn Leu Thr Phe Asp Pro Asp Thr Ala Gln Gln Asn Leu 
    290                 295                 300                 


Val Val Phe Ser Asp Gly Lys Ser Val Glu Cys Ser Glu Gln Lys Gln 
305                 310                 315                 320 


Ser Val Ser Asp Glu Pro Asn Arg Phe Asp Lys Ser Asn Cys Leu Val 
                325                 330                 335     


Ser Lys Glu Ser Phe Thr Glu Gly Glu His Tyr Trp Glu Val Leu Val 
            340                 345                 350         


Glu Asp Lys Pro Arg Trp Ala Leu Gly Val Ile Ser Glu Thr Ala Asn 
        355                 360                 365             


Arg Lys Gly Lys Leu His Ala Ser Pro Ser Asn Gly Phe Trp Leu Ile 
    370                 375                 380                 


Gly Cys Lys Glu Gly Lys Val Tyr Glu Ala His Thr Glu Gln Lys Glu 
385                 390                 395                 400 


Pro Arg Val Leu Arg Val Glu Gly Arg Pro Glu Lys Ile Gly Ile Tyr 
                405                 410                 415     


Leu Ser Phe Ser Asp Gly Val Val Ser Phe Phe Asp Ser Ser Asp Glu 
            420                 425                 430         


Asp Asn Ile Lys Leu Leu Tyr Thr Phe Asn Glu Arg Phe Ser Gly Arg 
        435                 440                 445             


Leu His Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 
    450                 455                 460                 


Gln Pro Leu Lys Ile Phe Tyr Pro Pro Ala Glu Gln Leu 
465                 470                 475         


<210>  17
<211>  101
<212>  PRT
<213>  Human immunodeficiency virus type 1


<220>
<221>  PEPTIDE
<222>  (1)..(101)
<223>  HIV-1 TAT protein

<400>  17

Met Glu Pro Val Asp Pro Asn Leu Glu Pro Trp Lys His Pro Gly Ser 
1               5                   10                  15      


Gln Pro Pro Thr Ala Cys Ser Lys Cys Tyr Cys Lys Lys Cys Cys Trp 
            20                  25                  30          


His Cys Gln Leu Cys Phe Leu Lys Lys Gly Leu Gly Ile Ser Tyr Gly 
        35                  40                  45              


Arg Lys Lys Arg Lys His Arg Arg Gly Thr Pro Gln Ser Ser Lys Asp 
    50                  55                  60                  


His Gln Asn Pro Ile Pro Glu Gln Pro Leu Pro Ile Ile Arg Gly Asn 
65                  70                  75                  80  


Gln Thr Gly Pro Lys Glu Gln Lys Lys Thr Val Ala Ser Lys Ala Glu 
                85                  90                  95      


Arg Asp Leu Cys Ala 
            100     


<210>  18
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized


<220>
<221>  misc_feature
<222>  (1)..(66)
<223>  Scrambled shRNA for MG53 - sense

<400>  18
gtacctcgcc tgccgtccaa agttgtaatc aagagttaca actttggacg gcaggctttt     60

tggaaa                                                                66


<210>  19
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized


<220>
<221>  misc_feature
<222>  (1)..(66)
<223>  Scrambled shRNA for MG53 - antisense

<400>  19
agcttttcca aaaagcctgc cgtccaaagt tgtaactctt gattacaact ttggacggca     60

ggcgag                                                                66


<210>  20
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized


<220>
<221>  misc_feature
<222>  (1)..(66)
<223>  shRNA for MG53

<400>  20
gtacctcgag ctgtcaagcc tgaactcttc aagagagagt tcaggcttga cagctctttt     60

tggaaa                                                                66


<210>  21
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized


<220>
<221>  misc_feature
<222>  (1)..(66)
<223>  shRNA for MG53

<400>  21
agcttttcca aaaagagctg tcaagcctga actctctctt gaagagttca ggcttgacag     60

ctcgag                                                                66


<210>  22
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized


<220>
<221>  misc_feature
<222>  (1)..(65)
<223>  Scrambled shRNA for Cav-3 - sense

<400>  22
gatccgcgga gacatagcct gtaattcaag agattacagg ctatgtctcc gcttttttac     60

cggtg                                                                 65


<210>  23
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized


<220>
<221>  misc_feature
<222>  (1)..(65)
<223>  Scrambled shRNA for Cav-3 - antisense

<400>  23
aattcaccgg taaaaaagcg gagacatagc ctgtaatctc ttgaattaca ggctatgtct     60

ccgcg                                                                 65


<210>  24
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized


<220>
<221>  misc_feature
<222>  (1)..(65)
<223>  shRNA for Cav-3 - sense

<400>  24
gatccggaca ttcactgcaa ggagttcaag agactccttg cagtgaatgt ccttttttac     60

cggtg                                                                 65


<210>  25
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized


<220>
<221>  misc_feature
<222>  (1)..(65)
<223>  shRNA for Cav-3 - antisense

<400>  25
aattcaccgg taaaaaagga cattcactgc aaggagtctc ttgaactcct tgcagtgaat     60

gtccg                                                                 65


