                         SEQUENCE LISTING

<110>  Deciphera Pharmaceuticals, LLC
       Flynn, Daniel L.
       Petillo, Peter A.
       Kaufman, Michael D.
 
<120>  Methods and Compositions for the Treatment of Myeloproliferative 
       Diseases and Other Proliferative Diseases

<130>  DECP-010/03WO

<140>  PCT/US2011/050856
<141>  2011-09-08

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Tyr Tyr His His His His His His Asp Tyr Asp Ile Pro Thr 
1               5                   10                  15      


Thr Glu Asn Leu Tyr Phe Gln Gly Ala Met Asp Pro Ser Ser Pro Asn 
            20                  25                  30          


Tyr Asp Lys Trp Glu Met Glu Arg Thr Asp Ile Thr Met Lys His Lys 
        35                  40                  45              


Leu Gly Gly Gly Gln Tyr Gly Glu Val Tyr Glu Gly Val Trp Lys Lys 
    50                  55                  60                  


Tyr Ser Leu Thr Val Ala Val Lys Thr Leu Lys Glu Asp Thr Met Glu 
65                  70                  75                  80  


Val Glu Glu Phe Leu Lys Glu Ala Ala Val Met Lys Glu Ile Lys His 
                85                  90                  95      


Pro Asn Leu Val Gln Leu Leu Gly Val Cys Thr Arg Glu Pro Pro Phe 
            100                 105                 110         


Tyr Ile Ile Thr Glu Phe Met Thr Tyr Gly Asn Leu Leu Asp Tyr Leu 
        115                 120                 125             


Arg Glu Cys Asn Arg Gln Glu Val Asn Ala Val Val Leu Leu Tyr Met 
    130                 135                 140                 


Ala Thr Gln Ile Ser Ser Ala Met Glu Tyr Leu Glu Lys Lys Asn Phe 
145                 150                 155                 160 


Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Gly Glu Asn His 
                165                 170                 175     


Leu Val Lys Val Ala Asp Phe Gly Leu Ser Arg Leu Met Thr Gly Asp 
            180                 185                 190         


Thr Tyr Thr Ala His Ala Gly Ala Lys Phe Pro Ile Lys Trp Thr Ala 
        195                 200                 205             


Pro Glu Ser Leu Ala Tyr Asn Lys Phe Ser Ile Lys Ser Asp Val Trp 
    210                 215                 220                 


Ala Phe Gly Val Leu Leu Trp Glu Ile Ala Thr Tyr Gly Met Ser Pro 
225                 230                 235                 240 


Tyr Pro Gly Ile Asp Leu Ser Gln Val Tyr Glu Leu Leu Glu Lys Asp 
                245                 250                 255     


Tyr Arg Met Glu Arg Pro Glu Gly Cys Pro Glu Lys Val Tyr Glu Leu 
            260                 265                 270         


Met Arg Ala Cys Trp Gln Trp Asn Pro Ser Asp Arg Pro Ser Phe Ala 
        275                 280                 285             


Glu Ile His Gln Ala Phe Glu Thr Met Phe Gln Glu Ser Ser Ile Ser 
    290                 295                 300                 


Asp Glu Val Glu Lys Glu Leu Gly Lys Arg Gly Thr 
305                 310                 315     


<210>  2
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Glu Tyr Met Pro Thr Glu His His His His His His Glu Asn 
1               5                   10                  15      


Leu Tyr Phe Gln Gly Thr Ser Met Asp Pro Ser Ser Pro Asn Tyr Asp 
            20                  25                  30          


Lys Trp Glu Met Glu Arg Thr Asp Ile Thr Met Lys His Lys Leu Gly 
        35                  40                  45              


Gly Gly Gln Tyr Gly Glu Val Tyr Glu Gly Val Trp Lys Lys Tyr Ser 
    50                  55                  60                  


Leu Thr Val Ala Val Lys Thr Leu Lys Glu Asp Thr Met Glu Val Glu 
65                  70                  75                  80  


Glu Phe Leu Lys Glu Ala Ala Val Met Lys Glu Ile Lys His Pro Asn 
                85                  90                  95      


Leu Val Gln Leu Leu Gly Val Cys Thr Arg Glu Pro Pro Phe Tyr Ile 
            100                 105                 110         


Ile Ile Glu Phe Met Thr Tyr Gly Asn Leu Leu Asp Tyr Leu Arg Glu 
        115                 120                 125             


Cys Asn Arg Gln Glu Val Asn Ala Val Val Leu Leu Tyr Met Ala Thr 
    130                 135                 140                 


Gln Ile Ser Ser Ala Met Glu Tyr Leu Glu Lys Lys Asn Phe Ile His 
145                 150                 155                 160 


Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Gly Glu Asn His Leu Val 
                165                 170                 175     


Lys Val Ala Asp Phe Gly Leu Ser Arg Leu Met Thr Gly Asp Thr Tyr 
            180                 185                 190         


Thr Ala His Ala Gly Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu 
        195                 200                 205             


Ser Leu Ala Tyr Asn Lys Phe Ser Ile Lys Ser Asp Val Trp Ala Phe 
    210                 215                 220                 


Gly Val Leu Leu Trp Glu Ile Ala Thr Tyr Gly Met Ser Pro Tyr Pro 
225                 230                 235                 240 


Gly Ile Asp Leu Ser Gln Val Tyr Glu Leu Leu Glu Lys Asp Tyr Arg 
                245                 250                 255     


Met Glu Arg Pro Glu Gly Cys Pro Glu Lys Val Tyr Glu Leu Met Arg 
            260                 265                 270         


Ala Cys Trp Gln Trp Asn Pro Ser Asp Arg Pro Ser Phe Ala Glu Ile 
        275                 280                 285             


His Gln Ala Phe Glu Thr Met Phe Gln Glu 
    290                 295             


<210>  3
<211>  2031
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Ile Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Asp Glu Gly Ala Phe His Gly Asp Ala Asp Gly Ser Phe Gly Thr 
            420                 425                 430         


Pro Pro Gly Tyr Gly Cys Ala Ala Asp Arg Ala Glu Glu Gln Arg Arg 
        435                 440                 445             


His Gln Asp Gly Leu Pro Tyr Ile Asp Asp Ser Pro Ser Ser Ser Pro 
    450                 455                 460                 


His Leu Ser Ser Lys Gly Arg Gly Ser Arg Asp Ala Leu Val Ser Gly 
465                 470                 475                 480 


Ala Leu Lys Ser Thr Lys Ala Ser Glu Leu Asp Leu Glu Lys Gly Leu 
                485                 490                 495     


Glu Met Arg Lys Trp Val Leu Ser Gly Ile Leu Ala Ser Glu Glu Thr 
            500                 505                 510         


Tyr Leu Ser His Leu Glu Ala Leu Leu Leu Pro Met Lys Pro Leu Lys 
        515                 520                 525             


Ala Ala Ala Thr Thr Ser Gln Pro Val Leu Thr Ser Gln Gln Ile Glu 
    530                 535                 540                 


Thr Ile Phe Phe Lys Val Pro Glu Leu Tyr Glu Ile His Lys Glu Ser 
545                 550                 555                 560 


Tyr Asp Gly Leu Phe Pro Arg Val Gln Gln Trp Ser His Gln Gln Arg 
                565                 570                 575     


Val Gly Asp Leu Phe Gln Lys Leu Ala Ser Gln Leu Gly Val Tyr Arg 
            580                 585                 590         


Ala Phe Val Asp Asn Tyr Gly Val Ala Met Glu Met Ala Glu Lys Cys 
        595                 600                 605             


Cys Gln Ala Asn Ala Gln Phe Ala Glu Ile Ser Glu Asn Leu Arg Ala 
    610                 615                 620                 


Arg Ser Asn Lys Asp Ala Lys Asp Pro Thr Thr Lys Asn Ser Leu Glu 
625                 630                 635                 640 


Thr Leu Leu Tyr Lys Pro Val Asp Arg Val Thr Arg Ser Thr Leu Val 
                645                 650                 655     


Leu His Asp Leu Leu Lys His Thr Pro Ala Ser His Pro Asp His Pro 
            660                 665                 670         


Leu Leu Gln Asp Ala Leu Arg Ile Ser Gln Asn Phe Leu Ser Ser Ile 
        675                 680                 685             


Asn Glu Glu Ile Thr Pro Arg Arg Gln Ser Met Thr Val Lys Lys Gly 
    690                 695                 700                 


Glu His Arg Gln Leu Leu Lys Asp Ser Phe Met Val Glu Leu Val Glu 
705                 710                 715                 720 


Gly Ala Arg Lys Leu Arg His Val Phe Leu Phe Thr Asp Leu Leu Leu 
                725                 730                 735     


Cys Thr Lys Leu Lys Lys Gln Ser Gly Gly Lys Thr Gln Gln Tyr Asp 
            740                 745                 750         


Cys Lys Trp Tyr Ile Pro Leu Thr Asp Leu Ser Phe Gln Met Val Asp 
        755                 760                 765             


Glu Leu Glu Ala Val Pro Asn Ile Pro Leu Val Pro Asp Glu Glu Leu 
    770                 775                 780                 


Asp Ala Leu Lys Ile Lys Ile Ser Gln Ile Lys Ser Asp Ile Gln Arg 
785                 790                 795                 800 


Glu Lys Arg Ala Asn Lys Gly Ser Lys Ala Thr Glu Arg Leu Lys Lys 
                805                 810                 815     


Lys Leu Ser Glu Gln Glu Ser Leu Leu Leu Leu Met Ser Pro Ser Met 
            820                 825                 830         


Ala Phe Arg Val His Ser Arg Asn Gly Lys Ser Tyr Thr Phe Leu Ile 
        835                 840                 845             


Ser Ser Asp Tyr Glu Arg Ala Glu Trp Arg Glu Asn Ile Arg Glu Gln 
    850                 855                 860                 


Gln Lys Lys Cys Phe Arg Ser Phe Ser Leu Thr Ser Val Glu Leu Gln 
865                 870                 875                 880 


Met Leu Thr Asn Ser Cys Val Lys Leu Gln Thr Val His Ser Ile Pro 
                885                 890                 895     


Leu Thr Ile Asn Lys Glu Asp Asp Glu Ser Pro Gly Leu Tyr Gly Phe 
            900                 905                 910         


Leu Asn Val Ile Val His Ser Ala Thr Gly Phe Lys Gln Ser Ser Lys 
        915                 920                 925             


Ala Leu Gln Arg Pro Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser 
    930                 935                 940                 


Glu Ala Ala Arg Trp Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser 
945                 950                 955                 960 


Glu Asn Asp Pro Asn Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser 
                965                 970                 975     


Gly Asp Asn Thr Leu Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu 
            980                 985                 990         


Gly Tyr Asn His Asn Gly Glu Trp  Cys Glu Ala Gln Thr  Lys Asn Gly 
        995                 1000                 1005             


Gln Gly  Trp Val Pro Ser Asn  Tyr Ile Thr Pro Val  Asn Ser Leu 
    1010                 1015                 1020             


Glu Lys  His Ser Trp Tyr His  Gly Pro Val Ser Arg  Asn Ala Ala 
    1025                 1030                 1035             


Glu Tyr  Pro Leu Ser Ser Gly  Ile Asn Gly Ser Phe  Leu Val Arg 
    1040                 1045                 1050             


Glu Ser  Glu Ser Ser Pro Ser  Gln Arg Ser Ile Ser  Leu Arg Tyr 
    1055                 1060                 1065             


Glu Gly  Arg Val Tyr His Tyr  Arg Ile Asn Thr Ala  Ser Asp Gly 
    1070                 1075                 1080             


Lys Leu  Tyr Val Ser Ser Glu  Ser Arg Phe Asn Thr  Leu Ala Glu 
    1085                 1090                 1095             


Leu Val  His His His Ser Thr  Val Ala Asp Gly Leu  Ile Thr Thr 
    1100                 1105                 1110             


Leu His  Tyr Pro Ala Pro Lys  Arg Asn Lys Pro Thr  Val Tyr Gly 
    1115                 1120                 1125             


Val Ser  Pro Asn Tyr Asp Lys  Trp Glu Met Glu Arg  Thr Asp Ile 
    1130                 1135                 1140             


Thr Met  Lys His Lys Leu Gly  Gly Gly Gln Tyr Gly  Glu Val Tyr 
    1145                 1150                 1155             


Glu Gly  Val Trp Lys Lys Tyr  Ser Leu Thr Val Ala  Val Lys Thr 
    1160                 1165                 1170             


Leu Lys  Glu Asp Thr Met Glu  Val Glu Glu Phe Leu  Lys Glu Ala 
    1175                 1180                 1185             


Ala Val  Met Lys Glu Ile Lys  His Pro Asn Leu Val  Gln Leu Leu 
    1190                 1195                 1200             


Gly Val  Cys Thr Arg Glu Pro  Pro Phe Tyr Ile Ile  Thr Glu Phe 
    1205                 1210                 1215             


Met Thr  Tyr Gly Asn Leu Leu  Asp Tyr Leu Arg Glu  Cys Asn Arg 
    1220                 1225                 1230             


Gln Glu  Val Asn Ala Val Val  Leu Leu Tyr Met Ala  Thr Gln Ile 
    1235                 1240                 1245             


Ser Ser  Ala Met Glu Tyr Leu  Glu Lys Lys Asn Phe  Ile His Arg 
    1250                 1255                 1260             


Asp Leu  Ala Ala Arg Asn Cys  Leu Val Gly Glu Asn  His Leu Val 
    1265                 1270                 1275             


Lys Val  Ala Asp Phe Gly Leu  Ser Arg Leu Met Thr  Gly Asp Thr 
    1280                 1285                 1290             


Tyr Thr  Ala His Ala Gly Ala  Lys Phe Pro Ile Lys  Trp Thr Ala 
    1295                 1300                 1305             


Pro Glu  Ser Leu Ala Tyr Asn  Lys Phe Ser Ile Lys  Ser Asp Val 
    1310                 1315                 1320             


Trp Ala  Phe Gly Val Leu Leu  Trp Glu Ile Ala Thr  Tyr Gly Met 
    1325                 1330                 1335             


Ser Pro  Tyr Pro Gly Ile Asp  Arg Ser Gln Val Tyr  Glu Leu Leu 
    1340                 1345                 1350             


Glu Lys  Asp Tyr Arg Met Lys  Arg Pro Glu Gly Cys  Pro Glu Lys 
    1355                 1360                 1365             


Val Tyr  Glu Leu Met Arg Ala  Cys Trp Gln Trp Asn  Pro Ser Asp 
    1370                 1375                 1380             


Arg Pro  Ser Phe Ala Glu Ile  His Gln Ala Phe Glu  Thr Met Phe 
    1385                 1390                 1395             


Gln Glu  Ser Ser Ile Ser Asp  Glu Val Glu Lys Glu  Leu Gly Lys 
    1400                 1405                 1410             


Gln Gly  Val Arg Gly Ala Val  Thr Thr Leu Leu Gln  Ala Pro Glu 
    1415                 1420                 1425             


Leu Pro  Thr Lys Thr Arg Thr  Ser Arg Arg Ala Ala  Glu His Arg 
    1430                 1435                 1440             


Asp Thr  Thr Asp Val Pro Glu  Met Pro His Ser Lys  Gly Gln Gly 
    1445                 1450                 1455             


Glu Ser  Asp Pro Leu Asp His  Glu Pro Ala Val Ser  Pro Leu Leu 
    1460                 1465                 1470             


Pro Arg  Lys Glu Arg Gly Pro  Pro Glu Gly Gly Leu  Asn Glu Asp 
    1475                 1480                 1485             


Glu Arg  Leu Leu Pro Lys Asp  Lys Lys Thr Asn Leu  Phe Ser Ala 
    1490                 1495                 1500             


Leu Ile  Lys Lys Lys Lys Lys  Thr Ala Pro Thr Pro  Pro Lys Arg 
    1505                 1510                 1515             


Ser Ser  Ser Phe Arg Glu Met  Asp Gly Gln Pro Glu  Arg Arg Gly 
    1520                 1525                 1530             


Ala Gly  Glu Glu Glu Gly Arg  Asp Ile Ser Asn Gly  Ala Leu Ala 
    1535                 1540                 1545             


Phe Thr  Pro Leu Asp Thr Ala  Asp Pro Ala Lys Ser  Pro Lys Pro 
    1550                 1555                 1560             


Ser Asn  Gly Ala Gly Val Pro  Asn Gly Ala Leu Arg  Glu Ser Gly 
    1565                 1570                 1575             


Gly Ser  Gly Phe Arg Ser Pro  His Leu Trp Lys Lys  Ser Ser Thr 
    1580                 1585                 1590             


Leu Thr  Ser Ser Arg Leu Ala  Thr Gly Glu Glu Glu  Gly Gly Gly 
    1595                 1600                 1605             


Ser Ser  Ser Lys Arg Phe Leu  Arg Ser Cys Ser Val  Ser Cys Val 
    1610                 1615                 1620             


Pro His  Gly Ala Lys Asp Thr  Glu Trp Arg Ser Val  Thr Leu Pro 
    1625                 1630                 1635             


Arg Asp  Leu Gln Ser Thr Gly  Arg Gln Phe Asp Ser  Ser Thr Phe 
    1640                 1645                 1650             


Gly Gly  His Lys Ser Glu Lys  Pro Ala Leu Pro Arg  Lys Arg Ala 
    1655                 1660                 1665             


Gly Glu  Asn Arg Ser Asp Gln  Val Thr Arg Gly Thr  Val Thr Pro 
    1670                 1675                 1680             


Pro Pro  Arg Leu Val Lys Lys  Asn Glu Glu Ala Ala  Asp Glu Val 
    1685                 1690                 1695             


Phe Lys  Asp Ile Met Glu Ser  Ser Pro Gly Ser Ser  Pro Pro Asn 
    1700                 1705                 1710             


Leu Thr  Pro Lys Pro Leu Arg  Arg Gln Val Thr Val  Ala Pro Ala 
    1715                 1720                 1725             


Ser Gly  Leu Pro His Lys Glu  Glu Ala Trp Lys Gly  Ser Ala Leu 
    1730                 1735                 1740             


Gly Thr  Pro Ala Ala Ala Glu  Pro Val Thr Pro Thr  Ser Lys Ala 
    1745                 1750                 1755             


Gly Ser  Gly Ala Pro Arg Gly  Thr Ser Lys Gly Pro  Ala Glu Glu 
    1760                 1765                 1770             


Ser Arg  Val Arg Arg His Lys  His Ser Ser Glu Ser  Pro Gly Arg 
    1775                 1780                 1785             


Asp Lys  Gly Lys Leu Ser Lys  Leu Lys Pro Ala Pro  Pro Pro Pro 
    1790                 1795                 1800             


Pro Ala  Ala Ser Ala Gly Lys  Ala Gly Gly Lys Pro  Ser Gln Arg 
    1805                 1810                 1815             


Pro Gly  Gln Glu Ala Ala Gly  Glu Ala Val Leu Gly  Ala Lys Thr 
    1820                 1825                 1830             


Lys Ala  Thr Ser Leu Val Asp  Ala Val Asn Ser Asp  Ala Ala Lys 
    1835                 1840                 1845             


Pro Ser  Gln Pro Ala Glu Gly  Leu Lys Lys Pro Val  Leu Pro Ala 
    1850                 1855                 1860             


Thr Pro  Lys Pro His Pro Ala  Lys Pro Ser Gly Thr  Pro Ile Ser 
    1865                 1870                 1875             


Pro Ala  Pro Val Pro Leu Ser  Thr Leu Pro Ser Ala  Ser Ser Ala 
    1880                 1885                 1890             


Leu Ala  Gly Asp Gln Pro Ser  Ser Thr Ala Phe Ile  Pro Leu Ile 
    1895                 1900                 1905             


Ser Thr  Arg Val Ser Leu Arg  Lys Thr Arg Gln Pro  Pro Glu Arg 
    1910                 1915                 1920             


Ala Ser  Gly Ala Ile Thr Lys  Gly Val Val Leu Asp  Ser Thr Glu 
    1925                 1930                 1935             


Ala Leu  Cys Leu Ala Ile Ser  Gly Asn Ser Glu Gln  Met Ala Ser 
    1940                 1945                 1950             


His Ser  Ala Val Leu Glu Ala  Gly Lys Asn Leu Tyr  Thr Phe Cys 
    1955                 1960                 1965             


Val Ser  Tyr Val Asp Ser Ile  Gln Gln Met Arg Asn  Lys Phe Ala 
    1970                 1975                 1980             


Phe Arg  Glu Ala Ile Asn Lys  Leu Glu Asn Asn Leu  Arg Glu Leu 
    1985                 1990                 1995             


Gln Ile  Cys Pro Ala Ser Ala  Gly Ser Gly Pro Ala  Ala Thr Gln 
    2000                 2005                 2010             


Asp Phe  Ser Lys Leu Leu Ser  Ser Val Lys Glu Ile  Ser Asp Ile 
    2015                 2020                 2025             


Val Gln  Arg 
    2030     


<210>  4
<211>  2006
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Ile Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Asp Glu Gly Ala Phe His Gly Asp Ala Asp Gly Ser Phe Gly Thr 
            420                 425                 430         


Pro Pro Gly Tyr Gly Cys Ala Ala Asp Arg Ala Glu Glu Gln Arg Arg 
        435                 440                 445             


His Gln Asp Gly Leu Pro Tyr Ile Asp Asp Ser Pro Ser Ser Ser Pro 
    450                 455                 460                 


His Leu Ser Ser Lys Gly Arg Gly Ser Arg Asp Ala Leu Val Ser Gly 
465                 470                 475                 480 


Ala Leu Lys Ser Thr Lys Ala Ser Glu Leu Asp Leu Glu Lys Gly Leu 
                485                 490                 495     


Glu Met Arg Lys Trp Val Leu Ser Gly Ile Leu Ala Ser Glu Glu Thr 
            500                 505                 510         


Tyr Leu Ser His Leu Glu Ala Leu Leu Leu Pro Met Lys Pro Leu Lys 
        515                 520                 525             


Ala Ala Ala Thr Thr Ser Gln Pro Val Leu Thr Ser Gln Gln Ile Glu 
    530                 535                 540                 


Thr Ile Phe Phe Lys Val Pro Glu Leu Tyr Glu Ile His Lys Glu Ser 
545                 550                 555                 560 


Tyr Asp Gly Leu Phe Pro Arg Val Gln Gln Trp Ser His Gln Gln Arg 
                565                 570                 575     


Val Gly Asp Leu Phe Gln Lys Leu Ala Ser Gln Leu Gly Val Tyr Arg 
            580                 585                 590         


Ala Phe Val Asp Asn Tyr Gly Val Ala Met Glu Met Ala Glu Lys Cys 
        595                 600                 605             


Cys Gln Ala Asn Ala Gln Phe Ala Glu Ile Ser Glu Asn Leu Arg Ala 
    610                 615                 620                 


Arg Ser Asn Lys Asp Ala Lys Asp Pro Thr Thr Lys Asn Ser Leu Glu 
625                 630                 635                 640 


Thr Leu Leu Tyr Lys Pro Val Asp Arg Val Thr Arg Ser Thr Leu Val 
                645                 650                 655     


Leu His Asp Leu Leu Lys His Thr Pro Ala Ser His Pro Asp His Pro 
            660                 665                 670         


Leu Leu Gln Asp Ala Leu Arg Ile Ser Gln Asn Phe Leu Ser Ser Ile 
        675                 680                 685             


Asn Glu Glu Ile Thr Pro Arg Arg Gln Ser Met Thr Val Lys Lys Gly 
    690                 695                 700                 


Glu His Arg Gln Leu Leu Lys Asp Ser Phe Met Val Glu Leu Val Glu 
705                 710                 715                 720 


Gly Ala Arg Lys Leu Arg His Val Phe Leu Phe Thr Asp Leu Leu Leu 
                725                 730                 735     


Cys Thr Lys Leu Lys Lys Gln Ser Gly Gly Lys Thr Gln Gln Tyr Asp 
            740                 745                 750         


Cys Lys Trp Tyr Ile Pro Leu Thr Asp Leu Ser Phe Gln Met Val Asp 
        755                 760                 765             


Glu Leu Glu Ala Val Pro Asn Ile Pro Leu Val Pro Asp Glu Glu Leu 
    770                 775                 780                 


Asp Ala Leu Lys Ile Lys Ile Ser Gln Ile Lys Ser Asp Ile Gln Arg 
785                 790                 795                 800 


Glu Lys Arg Ala Asn Lys Gly Ser Lys Ala Thr Glu Arg Leu Lys Lys 
                805                 810                 815     


Lys Leu Ser Glu Gln Glu Ser Leu Leu Leu Leu Met Ser Pro Ser Met 
            820                 825                 830         


Ala Phe Arg Val His Ser Arg Asn Gly Lys Ser Tyr Thr Phe Leu Ile 
        835                 840                 845             


Ser Ser Asp Tyr Glu Arg Ala Glu Trp Arg Glu Asn Ile Arg Glu Gln 
    850                 855                 860                 


Gln Lys Lys Cys Phe Arg Ser Phe Ser Leu Thr Ser Val Glu Leu Gln 
865                 870                 875                 880 


Met Leu Thr Asn Ser Cys Val Lys Leu Gln Thr Val His Ser Ile Pro 
                885                 890                 895     


Leu Thr Ile Asn Lys Glu Glu Ala Leu Gln Arg Pro Val Ala Ser Asp 
            900                 905                 910         


Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp Asn Ser Lys Glu 
        915                 920                 925             


Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn Leu Phe Val Ala 
    930                 935                 940                 


Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu Ser Ile Thr Lys 
945                 950                 955                 960 


Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn Gly Glu Trp Cys 
                965                 970                 975     


Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp Val Pro Ser Asn Tyr Ile 
            980                 985                 990         


Thr Pro Val Asn Ser Leu Glu Lys  His Ser Trp Tyr His  Gly Pro Val 
        995                 1000                 1005             


Ser Arg  Asn Ala Ala Glu Tyr  Pro Leu Ser Ser Gly  Ile Asn Gly 
    1010                 1015                 1020             


Ser Phe  Leu Val Arg Glu Ser  Glu Ser Ser Pro Ser  Gln Arg Ser 
    1025                 1030                 1035             


Ile Ser  Leu Arg Tyr Glu Gly  Arg Val Tyr His Tyr  Arg Ile Asn 
    1040                 1045                 1050             


Thr Ala  Ser Asp Gly Lys Leu  Tyr Val Ser Ser Glu  Ser Arg Phe 
    1055                 1060                 1065             


Asn Thr  Leu Ala Glu Leu Val  His His His Ser Thr  Val Ala Asp 
    1070                 1075                 1080             


Gly Leu  Ile Thr Thr Leu His  Tyr Pro Ala Pro Lys  Arg Asn Lys 
    1085                 1090                 1095             


Pro Thr  Val Tyr Gly Val Ser  Pro Asn Tyr Asp Lys  Trp Glu Met 
    1100                 1105                 1110             


Glu Arg  Thr Asp Ile Thr Met  Lys His Lys Leu Gly  Gly Gly Gln 
    1115                 1120                 1125             


Tyr Gly  Glu Val Tyr Glu Gly  Val Trp Lys Lys Tyr  Ser Leu Thr 
    1130                 1135                 1140             


Val Ala  Val Lys Thr Leu Lys  Glu Asp Thr Met Glu  Val Glu Glu 
    1145                 1150                 1155             


Phe Leu  Lys Glu Ala Ala Val  Met Lys Glu Ile Lys  His Pro Asn 
    1160                 1165                 1170             


Leu Val  Gln Leu Leu Gly Val  Cys Thr Arg Glu Pro  Pro Phe Tyr 
    1175                 1180                 1185             


Ile Ile  Thr Glu Phe Met Thr  Tyr Gly Asn Leu Leu  Asp Tyr Leu 
    1190                 1195                 1200             


Arg Glu  Cys Asn Arg Gln Glu  Val Asn Ala Val Val  Leu Leu Tyr 
    1205                 1210                 1215             


Met Ala  Thr Gln Ile Ser Ser  Ala Met Glu Tyr Leu  Glu Lys Lys 
    1220                 1225                 1230             


Asn Phe  Ile His Arg Asp Leu  Ala Ala Arg Asn Cys  Leu Val Gly 
    1235                 1240                 1245             


Glu Asn  His Leu Val Lys Val  Ala Asp Phe Gly Leu  Ser Arg Leu 
    1250                 1255                 1260             


Met Thr  Gly Asp Thr Tyr Thr  Ala His Ala Gly Ala  Lys Phe Pro 
    1265                 1270                 1275             


Ile Lys  Trp Thr Ala Pro Glu  Ser Leu Ala Tyr Asn  Lys Phe Ser 
    1280                 1285                 1290             


Ile Lys  Ser Asp Val Trp Ala  Phe Gly Val Leu Leu  Trp Glu Ile 
    1295                 1300                 1305             


Ala Thr  Tyr Gly Met Ser Pro  Tyr Pro Gly Ile Asp  Arg Ser Gln 
    1310                 1315                 1320             


Val Tyr  Glu Leu Leu Glu Lys  Asp Tyr Arg Met Lys  Arg Pro Glu 
    1325                 1330                 1335             


Gly Cys  Pro Glu Lys Val Tyr  Glu Leu Met Arg Ala  Cys Trp Gln 
    1340                 1345                 1350             


Trp Asn  Pro Ser Asp Arg Pro  Ser Phe Ala Glu Ile  His Gln Ala 
    1355                 1360                 1365             


Phe Glu  Thr Met Phe Gln Glu  Ser Ser Ile Ser Asp  Glu Val Glu 
    1370                 1375                 1380             


Lys Glu  Leu Gly Lys Gln Gly  Val Arg Gly Ala Val  Thr Thr Leu 
    1385                 1390                 1395             


Leu Gln  Ala Pro Glu Leu Pro  Thr Lys Thr Arg Thr  Ser Arg Arg 
    1400                 1405                 1410             


Ala Ala  Glu His Arg Asp Thr  Thr Asp Val Pro Glu  Met Pro His 
    1415                 1420                 1425             


Ser Lys  Gly Gln Gly Glu Ser  Asp Pro Leu Asp His  Glu Pro Ala 
    1430                 1435                 1440             


Val Ser  Pro Leu Leu Pro Arg  Lys Glu Arg Gly Pro  Pro Glu Gly 
    1445                 1450                 1455             


Gly Leu  Asn Glu Asp Glu Arg  Leu Leu Pro Lys Asp  Lys Lys Thr 
    1460                 1465                 1470             


Asn Leu  Phe Ser Ala Leu Ile  Lys Lys Lys Lys Lys  Thr Ala Pro 
    1475                 1480                 1485             


Thr Pro  Pro Lys Arg Ser Ser  Ser Phe Arg Glu Met  Asp Gly Gln 
    1490                 1495                 1500             


Pro Glu  Arg Arg Gly Ala Gly  Glu Glu Glu Gly Arg  Asp Ile Ser 
    1505                 1510                 1515             


Asn Gly  Ala Leu Ala Phe Thr  Pro Leu Asp Thr Ala  Asp Pro Ala 
    1520                 1525                 1530             


Lys Ser  Pro Lys Pro Ser Asn  Gly Ala Gly Val Pro  Asn Gly Ala 
    1535                 1540                 1545             


Leu Arg  Glu Ser Gly Gly Ser  Gly Phe Arg Ser Pro  His Leu Trp 
    1550                 1555                 1560             


Lys Lys  Ser Ser Thr Leu Thr  Ser Ser Arg Leu Ala  Thr Gly Glu 
    1565                 1570                 1575             


Glu Glu  Gly Gly Gly Ser Ser  Ser Lys Arg Phe Leu  Arg Ser Cys 
    1580                 1585                 1590             


Ser Val  Ser Cys Val Pro His  Gly Ala Lys Asp Thr  Glu Trp Arg 
    1595                 1600                 1605             


Ser Val  Thr Leu Pro Arg Asp  Leu Gln Ser Thr Gly  Arg Gln Phe 
    1610                 1615                 1620             


Asp Ser  Ser Thr Phe Gly Gly  His Lys Ser Glu Lys  Pro Ala Leu 
    1625                 1630                 1635             


Pro Arg  Lys Arg Ala Gly Glu  Asn Arg Ser Asp Gln  Val Thr Arg 
    1640                 1645                 1650             


Gly Thr  Val Thr Pro Pro Pro  Arg Leu Val Lys Lys  Asn Glu Glu 
    1655                 1660                 1665             


Ala Ala  Asp Glu Val Phe Lys  Asp Ile Met Glu Ser  Ser Pro Gly 
    1670                 1675                 1680             


Ser Ser  Pro Pro Asn Leu Thr  Pro Lys Pro Leu Arg  Arg Gln Val 
    1685                 1690                 1695             


Thr Val  Ala Pro Ala Ser Gly  Leu Pro His Lys Glu  Glu Ala Trp 
    1700                 1705                 1710             


Lys Gly  Ser Ala Leu Gly Thr  Pro Ala Ala Ala Glu  Pro Val Thr 
    1715                 1720                 1725             


Pro Thr  Ser Lys Ala Gly Ser  Gly Ala Pro Arg Gly  Thr Ser Lys 
    1730                 1735                 1740             


Gly Pro  Ala Glu Glu Ser Arg  Val Arg Arg His Lys  His Ser Ser 
    1745                 1750                 1755             


Glu Ser  Pro Gly Arg Asp Lys  Gly Lys Leu Ser Lys  Leu Lys Pro 
    1760                 1765                 1770             


Ala Pro  Pro Pro Pro Pro Ala  Ala Ser Ala Gly Lys  Ala Gly Gly 
    1775                 1780                 1785             


Lys Pro  Ser Gln Arg Pro Gly  Gln Glu Ala Ala Gly  Glu Ala Val 
    1790                 1795                 1800             


Leu Gly  Ala Lys Thr Lys Ala  Thr Ser Leu Val Asp  Ala Val Asn 
    1805                 1810                 1815             


Ser Asp  Ala Ala Lys Pro Ser  Gln Pro Ala Glu Gly  Leu Lys Lys 
    1820                 1825                 1830             


Pro Val  Leu Pro Ala Thr Pro  Lys Pro His Pro Ala  Lys Pro Ser 
    1835                 1840                 1845             


Gly Thr  Pro Ile Ser Pro Ala  Pro Val Pro Leu Ser  Thr Leu Pro 
    1850                 1855                 1860             


Ser Ala  Ser Ser Ala Leu Ala  Gly Asp Gln Pro Ser  Ser Thr Ala 
    1865                 1870                 1875             


Phe Ile  Pro Leu Ile Ser Thr  Arg Val Ser Leu Arg  Lys Thr Arg 
    1880                 1885                 1890             


Gln Pro  Pro Glu Arg Ala Ser  Gly Ala Ile Thr Lys  Gly Val Val 
    1895                 1900                 1905             


Leu Asp  Ser Thr Glu Ala Leu  Cys Leu Ala Ile Ser  Gly Asn Ser 
    1910                 1915                 1920             


Glu Gln  Met Ala Ser His Ser  Ala Val Leu Glu Ala  Gly Lys Asn 
    1925                 1930                 1935             


Leu Tyr  Thr Phe Cys Val Ser  Tyr Val Asp Ser Ile  Gln Gln Met 
    1940                 1945                 1950             


Arg Asn  Lys Phe Ala Phe Arg  Glu Ala Ile Asn Lys  Leu Glu Asn 
    1955                 1960                 1965             


Asn Leu  Arg Glu Leu Gln Ile  Cys Pro Ala Ser Ala  Gly Ser Gly 
    1970                 1975                 1980             


Pro Ala  Ala Thr Gln Asp Phe  Ser Lys Leu Leu Ser  Ser Val Lys 
    1985                 1990                 1995             


Glu Ile  Ser Asp Ile Val Gln  Arg 
    2000                 2005     


<210>  5
<211>  1530
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Ile Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Asp Glu Gly Ala Phe His Gly Asp Ala Glu Ala Leu Gln Arg Pro 
            420                 425                 430         


Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp 
        435                 440                 445             


Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn 
    450                 455                 460                 


Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu 
465                 470                 475                 480 


Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn 
                485                 490                 495     


Gly Glu Trp Cys Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp Val Pro 
            500                 505                 510         


Ser Asn Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr 
        515                 520                 525             


His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Pro Leu Ser Ser Gly 
    530                 535                 540                 


Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Ser Gln 
545                 550                 555                 560 


Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile 
                565                 570                 575     


Asn Thr Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu Ser Arg Phe 
            580                 585                 590         


Asn Thr Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly 
        595                 600                 605             


Leu Ile Thr Thr Leu His Tyr Pro Ala Pro Lys Arg Asn Lys Pro Thr 
    610                 615                 620                 


Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu Arg Thr 
625                 630                 635                 640 


Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val 
                645                 650                 655     


Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr 
            660                 665                 670         


Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala 
        675                 680                 685             


Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val 
    690                 695                 700                 


Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Thr Glu Phe Met Thr Tyr 
705                 710                 715                 720 


Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu Val Asn 
                725                 730                 735     


Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu 
            740                 745                 750         


Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn 
        755                 760                 765             


Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe Gly Leu 
    770                 775                 780                 


Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys 
785                 790                 795                 800 


Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Lys Phe 
                805                 810                 815     


Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile 
            820                 825                 830         


Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Arg Ser Gln Val 
        835                 840                 845             


Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Lys Arg Pro Glu Gly Cys 
    850                 855                 860                 


Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln Trp Asn Pro 
865                 870                 875                 880 


Ser Asp Arg Pro Ser Phe Ala Glu Ile His Gln Ala Phe Glu Thr Met 
                885                 890                 895     


Phe Gln Glu Ser Ser Ile Ser Asp Glu Val Glu Lys Glu Leu Gly Lys 
            900                 905                 910         


Gln Gly Val Arg Gly Ala Val Thr Thr Leu Leu Gln Ala Pro Glu Leu 
        915                 920                 925             


Pro Thr Lys Thr Arg Thr Ser Arg Arg Ala Ala Glu His Arg Asp Thr 
    930                 935                 940                 


Thr Asp Val Pro Glu Met Pro His Ser Lys Gly Gln Gly Glu Ser Asp 
945                 950                 955                 960 


Pro Leu Asp His Glu Pro Ala Val Ser Pro Leu Leu Pro Arg Lys Glu 
                965                 970                 975     


Arg Gly Pro Pro Glu Gly Gly Leu Asn Glu Asp Glu Arg Leu Leu Pro 
            980                 985                 990         


Lys Asp Lys Lys Thr Asn Leu Phe  Ser Ala Leu Ile Lys  Lys Lys Lys 
        995                 1000                 1005             


Lys Thr  Ala Pro Thr Pro Pro  Lys Arg Ser Ser Ser  Phe Arg Glu 
    1010                 1015                 1020             


Met Asp  Gly Gln Pro Glu Arg  Arg Gly Ala Gly Glu  Glu Glu Gly 
    1025                 1030                 1035             


Arg Asp  Ile Ser Asn Gly Ala  Leu Ala Phe Thr Pro  Leu Asp Thr 
    1040                 1045                 1050             


Ala Asp  Pro Ala Lys Ser Pro  Lys Pro Ser Asn Gly  Ala Gly Val 
    1055                 1060                 1065             


Pro Asn  Gly Ala Leu Arg Glu  Ser Gly Gly Ser Gly  Phe Arg Ser 
    1070                 1075                 1080             


Pro His  Leu Trp Lys Lys Ser  Ser Thr Leu Thr Ser  Ser Arg Leu 
    1085                 1090                 1095             


Ala Thr  Gly Glu Glu Glu Gly  Gly Gly Ser Ser Ser  Lys Arg Phe 
    1100                 1105                 1110             


Leu Arg  Ser Cys Ser Val Ser  Cys Val Pro His Gly  Ala Lys Asp 
    1115                 1120                 1125             


Thr Glu  Trp Arg Ser Val Thr  Leu Pro Arg Asp Leu  Gln Ser Thr 
    1130                 1135                 1140             


Gly Arg  Gln Phe Asp Ser Ser  Thr Phe Gly Gly His  Lys Ser Glu 
    1145                 1150                 1155             


Lys Pro  Ala Leu Pro Arg Lys  Arg Ala Gly Glu Asn  Arg Ser Asp 
    1160                 1165                 1170             


Gln Val  Thr Arg Gly Thr Val  Thr Pro Pro Pro Arg  Leu Val Lys 
    1175                 1180                 1185             


Lys Asn  Glu Glu Ala Ala Asp  Glu Val Phe Lys Asp  Ile Met Glu 
    1190                 1195                 1200             


Ser Ser  Pro Gly Ser Ser Pro  Pro Asn Leu Thr Pro  Lys Pro Leu 
    1205                 1210                 1215             


Arg Arg  Gln Val Thr Val Ala  Pro Ala Ser Gly Leu  Pro His Lys 
    1220                 1225                 1230             


Glu Glu  Ala Trp Lys Gly Ser  Ala Leu Gly Thr Pro  Ala Ala Ala 
    1235                 1240                 1245             


Glu Pro  Val Thr Pro Thr Ser  Lys Ala Gly Ser Gly  Ala Pro Arg 
    1250                 1255                 1260             


Gly Thr  Ser Lys Gly Pro Ala  Glu Glu Ser Arg Val  Arg Arg His 
    1265                 1270                 1275             


Lys His  Ser Ser Glu Ser Pro  Gly Arg Asp Lys Gly  Lys Leu Ser 
    1280                 1285                 1290             


Lys Leu  Lys Pro Ala Pro Pro  Pro Pro Pro Ala Ala  Ser Ala Gly 
    1295                 1300                 1305             


Lys Ala  Gly Gly Lys Pro Ser  Gln Arg Pro Gly Gln  Glu Ala Ala 
    1310                 1315                 1320             


Gly Glu  Ala Val Leu Gly Ala  Lys Thr Lys Ala Thr  Ser Leu Val 
    1325                 1330                 1335             


Asp Ala  Val Asn Ser Asp Ala  Ala Lys Pro Ser Gln  Pro Ala Glu 
    1340                 1345                 1350             


Gly Leu  Lys Lys Pro Val Leu  Pro Ala Thr Pro Lys  Pro His Pro 
    1355                 1360                 1365             


Ala Lys  Pro Ser Gly Thr Pro  Ile Ser Pro Ala Pro  Val Pro Leu 
    1370                 1375                 1380             


Ser Thr  Leu Pro Ser Ala Ser  Ser Ala Leu Ala Gly  Asp Gln Pro 
    1385                 1390                 1395             


Ser Ser  Thr Ala Phe Ile Pro  Leu Ile Ser Thr Arg  Val Ser Leu 
    1400                 1405                 1410             


Arg Lys  Thr Arg Gln Pro Pro  Glu Arg Ala Ser Gly  Ala Ile Thr 
    1415                 1420                 1425             


Lys Gly  Val Val Leu Asp Ser  Thr Glu Ala Leu Cys  Leu Ala Ile 
    1430                 1435                 1440             


Ser Gly  Asn Ser Glu Gln Met  Ala Ser His Ser Ala  Val Leu Glu 
    1445                 1450                 1455             


Ala Gly  Lys Asn Leu Tyr Thr  Phe Cys Val Ser Tyr  Val Asp Ser 
    1460                 1465                 1470             


Ile Gln  Gln Met Arg Asn Lys  Phe Ala Phe Arg Glu  Ala Ile Asn 
    1475                 1480                 1485             


Lys Leu  Glu Asn Asn Leu Arg  Glu Leu Gln Ile Cys  Pro Ala Ser 
    1490                 1495                 1500             


Ala Gly  Ser Gly Pro Ala Ala  Thr Gln Asp Phe Ser  Lys Leu Leu 
    1505                 1510                 1515             


Ser Ser  Val Lys Glu Ile Ser  Asp Ile Val Gln Arg  
    1520                 1525                 1530 


<210>  6
<211>  2031
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Ile Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Asp Glu Gly Ala Phe His Gly Asp Ala Asp Gly Ser Phe Gly Thr 
            420                 425                 430         


Pro Pro Gly Tyr Gly Cys Ala Ala Asp Arg Ala Glu Glu Gln Arg Arg 
        435                 440                 445             


His Gln Asp Gly Leu Pro Tyr Ile Asp Asp Ser Pro Ser Ser Ser Pro 
    450                 455                 460                 


His Leu Ser Ser Lys Gly Arg Gly Ser Arg Asp Ala Leu Val Ser Gly 
465                 470                 475                 480 


Ala Leu Lys Ser Thr Lys Ala Ser Glu Leu Asp Leu Glu Lys Gly Leu 
                485                 490                 495     


Glu Met Arg Lys Trp Val Leu Ser Gly Ile Leu Ala Ser Glu Glu Thr 
            500                 505                 510         


Tyr Leu Ser His Leu Glu Ala Leu Leu Leu Pro Met Lys Pro Leu Lys 
        515                 520                 525             


Ala Ala Ala Thr Thr Ser Gln Pro Val Leu Thr Ser Gln Gln Ile Glu 
    530                 535                 540                 


Thr Ile Phe Phe Lys Val Pro Glu Leu Tyr Glu Ile His Lys Glu Ser 
545                 550                 555                 560 


Tyr Asp Gly Leu Phe Pro Arg Val Gln Gln Trp Ser His Gln Gln Arg 
                565                 570                 575     


Val Gly Asp Leu Phe Gln Lys Leu Ala Ser Gln Leu Gly Val Tyr Arg 
            580                 585                 590         


Ala Phe Val Asp Asn Tyr Gly Val Ala Met Glu Met Ala Glu Lys Cys 
        595                 600                 605             


Cys Gln Ala Asn Ala Gln Phe Ala Glu Ile Ser Glu Asn Leu Arg Ala 
    610                 615                 620                 


Arg Ser Asn Lys Asp Ala Lys Asp Pro Thr Thr Lys Asn Ser Leu Glu 
625                 630                 635                 640 


Thr Leu Leu Tyr Lys Pro Val Asp Arg Val Thr Arg Ser Thr Leu Val 
                645                 650                 655     


Leu His Asp Leu Leu Lys His Thr Pro Ala Ser His Pro Asp His Pro 
            660                 665                 670         


Leu Leu Gln Asp Ala Leu Arg Ile Ser Gln Asn Phe Leu Ser Ser Ile 
        675                 680                 685             


Asn Glu Glu Ile Thr Pro Arg Arg Gln Ser Met Thr Val Lys Lys Gly 
    690                 695                 700                 


Glu His Arg Gln Leu Leu Lys Asp Ser Phe Met Val Glu Leu Val Glu 
705                 710                 715                 720 


Gly Ala Arg Lys Leu Arg His Val Phe Leu Phe Thr Asp Leu Leu Leu 
                725                 730                 735     


Cys Thr Lys Leu Lys Lys Gln Ser Gly Gly Lys Thr Gln Gln Tyr Asp 
            740                 745                 750         


Cys Lys Trp Tyr Ile Pro Leu Thr Asp Leu Ser Phe Gln Met Val Asp 
        755                 760                 765             


Glu Leu Glu Ala Val Pro Asn Ile Pro Leu Val Pro Asp Glu Glu Leu 
    770                 775                 780                 


Asp Ala Leu Lys Ile Lys Ile Ser Gln Ile Lys Ser Asp Ile Gln Arg 
785                 790                 795                 800 


Glu Lys Arg Ala Asn Lys Gly Ser Lys Ala Thr Glu Arg Leu Lys Lys 
                805                 810                 815     


Lys Leu Ser Glu Gln Glu Ser Leu Leu Leu Leu Met Ser Pro Ser Met 
            820                 825                 830         


Ala Phe Arg Val His Ser Arg Asn Gly Lys Ser Tyr Thr Phe Leu Ile 
        835                 840                 845             


Ser Ser Asp Tyr Glu Arg Ala Glu Trp Arg Glu Asn Ile Arg Glu Gln 
    850                 855                 860                 


Gln Lys Lys Cys Phe Arg Ser Phe Ser Leu Thr Ser Val Glu Leu Gln 
865                 870                 875                 880 


Met Leu Thr Asn Ser Cys Val Lys Leu Gln Thr Val His Ser Ile Pro 
                885                 890                 895     


Leu Thr Ile Asn Lys Glu Asp Asp Glu Ser Pro Gly Leu Tyr Gly Phe 
            900                 905                 910         


Leu Asn Val Ile Val His Ser Ala Thr Gly Phe Lys Gln Ser Ser Lys 
        915                 920                 925             


Ala Leu Gln Arg Pro Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser 
    930                 935                 940                 


Glu Ala Ala Arg Trp Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser 
945                 950                 955                 960 


Glu Asn Asp Pro Asn Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser 
                965                 970                 975     


Gly Asp Asn Thr Leu Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu 
            980                 985                 990         


Gly Tyr Asn His Asn Gly Glu Trp  Cys Glu Ala Gln Thr  Lys Asn Gly 
        995                 1000                 1005             


Gln Gly  Trp Val Pro Ser Asn  Tyr Ile Thr Pro Val  Asn Ser Leu 
    1010                 1015                 1020             


Glu Lys  His Ser Trp Tyr His  Gly Pro Val Ser Arg  Asn Ala Ala 
    1025                 1030                 1035             


Glu Tyr  Pro Leu Ser Ser Gly  Ile Asn Gly Ser Phe  Leu Val Arg 
    1040                 1045                 1050             


Glu Ser  Glu Ser Ser Pro Ser  Gln Arg Ser Ile Ser  Leu Arg Tyr 
    1055                 1060                 1065             


Glu Gly  Arg Val Tyr His Tyr  Arg Ile Asn Thr Ala  Ser Asp Gly 
    1070                 1075                 1080             


Lys Leu  Tyr Val Ser Ser Glu  Ser Arg Phe Asn Thr  Leu Ala Glu 
    1085                 1090                 1095             


Leu Val  His His His Ser Thr  Val Ala Asp Gly Leu  Ile Thr Thr 
    1100                 1105                 1110             


Leu His  Tyr Pro Ala Pro Lys  Arg Asn Lys Pro Thr  Val Tyr Gly 
    1115                 1120                 1125             


Val Ser  Pro Asn Tyr Asp Lys  Trp Glu Met Glu Arg  Thr Asp Ile 
    1130                 1135                 1140             


Thr Met  Lys His Lys Leu Gly  Gly Gly Gln Tyr Gly  Glu Val Tyr 
    1145                 1150                 1155             


Glu Gly  Val Trp Lys Lys Tyr  Ser Leu Thr Val Ala  Val Lys Thr 
    1160                 1165                 1170             


Leu Lys  Glu Asp Thr Met Glu  Val Glu Glu Phe Leu  Lys Glu Ala 
    1175                 1180                 1185             


Ala Val  Met Lys Glu Ile Lys  His Pro Asn Leu Val  Gln Leu Leu 
    1190                 1195                 1200             


Gly Val  Cys Thr Arg Glu Pro  Pro Phe Tyr Ile Ile  Ile Glu Phe 
    1205                 1210                 1215             


Met Thr  Tyr Gly Asn Leu Leu  Asp Tyr Leu Arg Glu  Cys Asn Arg 
    1220                 1225                 1230             


Gln Glu  Val Asn Ala Val Val  Leu Leu Tyr Met Ala  Thr Gln Ile 
    1235                 1240                 1245             


Ser Ser  Ala Met Glu Tyr Leu  Glu Lys Lys Asn Phe  Ile His Arg 
    1250                 1255                 1260             


Asp Leu  Ala Ala Arg Asn Cys  Leu Val Gly Glu Asn  His Leu Val 
    1265                 1270                 1275             


Lys Val  Ala Asp Phe Gly Leu  Ser Arg Leu Met Thr  Gly Asp Thr 
    1280                 1285                 1290             


Tyr Thr  Ala His Ala Gly Ala  Lys Phe Pro Ile Lys  Trp Thr Ala 
    1295                 1300                 1305             


Pro Glu  Ser Leu Ala Tyr Asn  Lys Phe Ser Ile Lys  Ser Asp Val 
    1310                 1315                 1320             


Trp Ala  Phe Gly Val Leu Leu  Trp Glu Ile Ala Thr  Tyr Gly Met 
    1325                 1330                 1335             


Ser Pro  Tyr Pro Gly Ile Asp  Arg Ser Gln Val Tyr  Glu Leu Leu 
    1340                 1345                 1350             


Glu Lys  Asp Tyr Arg Met Lys  Arg Pro Glu Gly Cys  Pro Glu Lys 
    1355                 1360                 1365             


Val Tyr  Glu Leu Met Arg Ala  Cys Trp Gln Trp Asn  Pro Ser Asp 
    1370                 1375                 1380             


Arg Pro  Ser Phe Ala Glu Ile  His Gln Ala Phe Glu  Thr Met Phe 
    1385                 1390                 1395             


Gln Glu  Ser Ser Ile Ser Asp  Glu Val Glu Lys Glu  Leu Gly Lys 
    1400                 1405                 1410             


Gln Gly  Val Arg Gly Ala Val  Thr Thr Leu Leu Gln  Ala Pro Glu 
    1415                 1420                 1425             


Leu Pro  Thr Lys Thr Arg Thr  Ser Arg Arg Ala Ala  Glu His Arg 
    1430                 1435                 1440             


Asp Thr  Thr Asp Val Pro Glu  Met Pro His Ser Lys  Gly Gln Gly 
    1445                 1450                 1455             


Glu Ser  Asp Pro Leu Asp His  Glu Pro Ala Val Ser  Pro Leu Leu 
    1460                 1465                 1470             


Pro Arg  Lys Glu Arg Gly Pro  Pro Glu Gly Gly Leu  Asn Glu Asp 
    1475                 1480                 1485             


Glu Arg  Leu Leu Pro Lys Asp  Lys Lys Thr Asn Leu  Phe Ser Ala 
    1490                 1495                 1500             


Leu Ile  Lys Lys Lys Lys Lys  Thr Ala Pro Thr Pro  Pro Lys Arg 
    1505                 1510                 1515             


Ser Ser  Ser Phe Arg Glu Met  Asp Gly Gln Pro Glu  Arg Arg Gly 
    1520                 1525                 1530             


Ala Gly  Glu Glu Glu Gly Arg  Asp Ile Ser Asn Gly  Ala Leu Ala 
    1535                 1540                 1545             


Phe Thr  Pro Leu Asp Thr Ala  Asp Pro Ala Lys Ser  Pro Lys Pro 
    1550                 1555                 1560             


Ser Asn  Gly Ala Gly Val Pro  Asn Gly Ala Leu Arg  Glu Ser Gly 
    1565                 1570                 1575             


Gly Ser  Gly Phe Arg Ser Pro  His Leu Trp Lys Lys  Ser Ser Thr 
    1580                 1585                 1590             


Leu Thr  Ser Ser Arg Leu Ala  Thr Gly Glu Glu Glu  Gly Gly Gly 
    1595                 1600                 1605             


Ser Ser  Ser Lys Arg Phe Leu  Arg Ser Cys Ser Val  Ser Cys Val 
    1610                 1615                 1620             


Pro His  Gly Ala Lys Asp Thr  Glu Trp Arg Ser Val  Thr Leu Pro 
    1625                 1630                 1635             


Arg Asp  Leu Gln Ser Thr Gly  Arg Gln Phe Asp Ser  Ser Thr Phe 
    1640                 1645                 1650             


Gly Gly  His Lys Ser Glu Lys  Pro Ala Leu Pro Arg  Lys Arg Ala 
    1655                 1660                 1665             


Gly Glu  Asn Arg Ser Asp Gln  Val Thr Arg Gly Thr  Val Thr Pro 
    1670                 1675                 1680             


Pro Pro  Arg Leu Val Lys Lys  Asn Glu Glu Ala Ala  Asp Glu Val 
    1685                 1690                 1695             


Phe Lys  Asp Ile Met Glu Ser  Ser Pro Gly Ser Ser  Pro Pro Asn 
    1700                 1705                 1710             


Leu Thr  Pro Lys Pro Leu Arg  Arg Gln Val Thr Val  Ala Pro Ala 
    1715                 1720                 1725             


Ser Gly  Leu Pro His Lys Glu  Glu Ala Trp Lys Gly  Ser Ala Leu 
    1730                 1735                 1740             


Gly Thr  Pro Ala Ala Ala Glu  Pro Val Thr Pro Thr  Ser Lys Ala 
    1745                 1750                 1755             


Gly Ser  Gly Ala Pro Arg Gly  Thr Ser Lys Gly Pro  Ala Glu Glu 
    1760                 1765                 1770             


Ser Arg  Val Arg Arg His Lys  His Ser Ser Glu Ser  Pro Gly Arg 
    1775                 1780                 1785             


Asp Lys  Gly Lys Leu Ser Lys  Leu Lys Pro Ala Pro  Pro Pro Pro 
    1790                 1795                 1800             


Pro Ala  Ala Ser Ala Gly Lys  Ala Gly Gly Lys Pro  Ser Gln Arg 
    1805                 1810                 1815             


Pro Gly  Gln Glu Ala Ala Gly  Glu Ala Val Leu Gly  Ala Lys Thr 
    1820                 1825                 1830             


Lys Ala  Thr Ser Leu Val Asp  Ala Val Asn Ser Asp  Ala Ala Lys 
    1835                 1840                 1845             


Pro Ser  Gln Pro Ala Glu Gly  Leu Lys Lys Pro Val  Leu Pro Ala 
    1850                 1855                 1860             


Thr Pro  Lys Pro His Pro Ala  Lys Pro Ser Gly Thr  Pro Ile Ser 
    1865                 1870                 1875             


Pro Ala  Pro Val Pro Leu Ser  Thr Leu Pro Ser Ala  Ser Ser Ala 
    1880                 1885                 1890             


Leu Ala  Gly Asp Gln Pro Ser  Ser Thr Ala Phe Ile  Pro Leu Ile 
    1895                 1900                 1905             


Ser Thr  Arg Val Ser Leu Arg  Lys Thr Arg Gln Pro  Pro Glu Arg 
    1910                 1915                 1920             


Ala Ser  Gly Ala Ile Thr Lys  Gly Val Val Leu Asp  Ser Thr Glu 
    1925                 1930                 1935             


Ala Leu  Cys Leu Ala Ile Ser  Gly Asn Ser Glu Gln  Met Ala Ser 
    1940                 1945                 1950             


His Ser  Ala Val Leu Glu Ala  Gly Lys Asn Leu Tyr  Thr Phe Cys 
    1955                 1960                 1965             


Val Ser  Tyr Val Asp Ser Ile  Gln Gln Met Arg Asn  Lys Phe Ala 
    1970                 1975                 1980             


Phe Arg  Glu Ala Ile Asn Lys  Leu Glu Asn Asn Leu  Arg Glu Leu 
    1985                 1990                 1995             


Gln Ile  Cys Pro Ala Ser Ala  Gly Ser Gly Pro Ala  Ala Thr Gln 
    2000                 2005                 2010             


Asp Phe  Ser Lys Leu Leu Ser  Ser Val Lys Glu Ile  Ser Asp Ile 
    2015                 2020                 2025             


Val Gln  Arg 
    2030     


<210>  7
<211>  2006
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Ile Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Asp Glu Gly Ala Phe His Gly Asp Ala Asp Gly Ser Phe Gly Thr 
            420                 425                 430         


Pro Pro Gly Tyr Gly Cys Ala Ala Asp Arg Ala Glu Glu Gln Arg Arg 
        435                 440                 445             


His Gln Asp Gly Leu Pro Tyr Ile Asp Asp Ser Pro Ser Ser Ser Pro 
    450                 455                 460                 


His Leu Ser Ser Lys Gly Arg Gly Ser Arg Asp Ala Leu Val Ser Gly 
465                 470                 475                 480 


Ala Leu Lys Ser Thr Lys Ala Ser Glu Leu Asp Leu Glu Lys Gly Leu 
                485                 490                 495     


Glu Met Arg Lys Trp Val Leu Ser Gly Ile Leu Ala Ser Glu Glu Thr 
            500                 505                 510         


Tyr Leu Ser His Leu Glu Ala Leu Leu Leu Pro Met Lys Pro Leu Lys 
        515                 520                 525             


Ala Ala Ala Thr Thr Ser Gln Pro Val Leu Thr Ser Gln Gln Ile Glu 
    530                 535                 540                 


Thr Ile Phe Phe Lys Val Pro Glu Leu Tyr Glu Ile His Lys Glu Ser 
545                 550                 555                 560 


Tyr Asp Gly Leu Phe Pro Arg Val Gln Gln Trp Ser His Gln Gln Arg 
                565                 570                 575     


Val Gly Asp Leu Phe Gln Lys Leu Ala Ser Gln Leu Gly Val Tyr Arg 
            580                 585                 590         


Ala Phe Val Asp Asn Tyr Gly Val Ala Met Glu Met Ala Glu Lys Cys 
        595                 600                 605             


Cys Gln Ala Asn Ala Gln Phe Ala Glu Ile Ser Glu Asn Leu Arg Ala 
    610                 615                 620                 


Arg Ser Asn Lys Asp Ala Lys Asp Pro Thr Thr Lys Asn Ser Leu Glu 
625                 630                 635                 640 


Thr Leu Leu Tyr Lys Pro Val Asp Arg Val Thr Arg Ser Thr Leu Val 
                645                 650                 655     


Leu His Asp Leu Leu Lys His Thr Pro Ala Ser His Pro Asp His Pro 
            660                 665                 670         


Leu Leu Gln Asp Ala Leu Arg Ile Ser Gln Asn Phe Leu Ser Ser Ile 
        675                 680                 685             


Asn Glu Glu Ile Thr Pro Arg Arg Gln Ser Met Thr Val Lys Lys Gly 
    690                 695                 700                 


Glu His Arg Gln Leu Leu Lys Asp Ser Phe Met Val Glu Leu Val Glu 
705                 710                 715                 720 


Gly Ala Arg Lys Leu Arg His Val Phe Leu Phe Thr Asp Leu Leu Leu 
                725                 730                 735     


Cys Thr Lys Leu Lys Lys Gln Ser Gly Gly Lys Thr Gln Gln Tyr Asp 
            740                 745                 750         


Cys Lys Trp Tyr Ile Pro Leu Thr Asp Leu Ser Phe Gln Met Val Asp 
        755                 760                 765             


Glu Leu Glu Ala Val Pro Asn Ile Pro Leu Val Pro Asp Glu Glu Leu 
    770                 775                 780                 


Asp Ala Leu Lys Ile Lys Ile Ser Gln Ile Lys Ser Asp Ile Gln Arg 
785                 790                 795                 800 


Glu Lys Arg Ala Asn Lys Gly Ser Lys Ala Thr Glu Arg Leu Lys Lys 
                805                 810                 815     


Lys Leu Ser Glu Gln Glu Ser Leu Leu Leu Leu Met Ser Pro Ser Met 
            820                 825                 830         


Ala Phe Arg Val His Ser Arg Asn Gly Lys Ser Tyr Thr Phe Leu Ile 
        835                 840                 845             


Ser Ser Asp Tyr Glu Arg Ala Glu Trp Arg Glu Asn Ile Arg Glu Gln 
    850                 855                 860                 


Gln Lys Lys Cys Phe Arg Ser Phe Ser Leu Thr Ser Val Glu Leu Gln 
865                 870                 875                 880 


Met Leu Thr Asn Ser Cys Val Lys Leu Gln Thr Val His Ser Ile Pro 
                885                 890                 895     


Leu Thr Ile Asn Lys Glu Glu Ala Leu Gln Arg Pro Val Ala Ser Asp 
            900                 905                 910         


Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp Asn Ser Lys Glu 
        915                 920                 925             


Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn Leu Phe Val Ala 
    930                 935                 940                 


Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu Ser Ile Thr Lys 
945                 950                 955                 960 


Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn Gly Glu Trp Cys 
                965                 970                 975     


Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp Val Pro Ser Asn Tyr Ile 
            980                 985                 990         


Thr Pro Val Asn Ser Leu Glu Lys  His Ser Trp Tyr His  Gly Pro Val 
        995                 1000                 1005             


Ser Arg  Asn Ala Ala Glu Tyr  Pro Leu Ser Ser Gly  Ile Asn Gly 
    1010                 1015                 1020             


Ser Phe  Leu Val Arg Glu Ser  Glu Ser Ser Pro Ser  Gln Arg Ser 
    1025                 1030                 1035             


Ile Ser  Leu Arg Tyr Glu Gly  Arg Val Tyr His Tyr  Arg Ile Asn 
    1040                 1045                 1050             


Thr Ala  Ser Asp Gly Lys Leu  Tyr Val Ser Ser Glu  Ser Arg Phe 
    1055                 1060                 1065             


Asn Thr  Leu Ala Glu Leu Val  His His His Ser Thr  Val Ala Asp 
    1070                 1075                 1080             


Gly Leu  Ile Thr Thr Leu His  Tyr Pro Ala Pro Lys  Arg Asn Lys 
    1085                 1090                 1095             


Pro Thr  Val Tyr Gly Val Ser  Pro Asn Tyr Asp Lys  Trp Glu Met 
    1100                 1105                 1110             


Glu Arg  Thr Asp Ile Thr Met  Lys His Lys Leu Gly  Gly Gly Gln 
    1115                 1120                 1125             


Tyr Gly  Glu Val Tyr Glu Gly  Val Trp Lys Lys Tyr  Ser Leu Thr 
    1130                 1135                 1140             


Val Ala  Val Lys Thr Leu Lys  Glu Asp Thr Met Glu  Val Glu Glu 
    1145                 1150                 1155             


Phe Leu  Lys Glu Ala Ala Val  Met Lys Glu Ile Lys  His Pro Asn 
    1160                 1165                 1170             


Leu Val  Gln Leu Leu Gly Val  Cys Thr Arg Glu Pro  Pro Phe Tyr 
    1175                 1180                 1185             


Ile Ile  Ile Glu Phe Met Thr  Tyr Gly Asn Leu Leu  Asp Tyr Leu 
    1190                 1195                 1200             


Arg Glu  Cys Asn Arg Gln Glu  Val Asn Ala Val Val  Leu Leu Tyr 
    1205                 1210                 1215             


Met Ala  Thr Gln Ile Ser Ser  Ala Met Glu Tyr Leu  Glu Lys Lys 
    1220                 1225                 1230             


Asn Phe  Ile His Arg Asp Leu  Ala Ala Arg Asn Cys  Leu Val Gly 
    1235                 1240                 1245             


Glu Asn  His Leu Val Lys Val  Ala Asp Phe Gly Leu  Ser Arg Leu 
    1250                 1255                 1260             


Met Thr  Gly Asp Thr Tyr Thr  Ala His Ala Gly Ala  Lys Phe Pro 
    1265                 1270                 1275             


Ile Lys  Trp Thr Ala Pro Glu  Ser Leu Ala Tyr Asn  Lys Phe Ser 
    1280                 1285                 1290             


Ile Lys  Ser Asp Val Trp Ala  Phe Gly Val Leu Leu  Trp Glu Ile 
    1295                 1300                 1305             


Ala Thr  Tyr Gly Met Ser Pro  Tyr Pro Gly Ile Asp  Arg Ser Gln 
    1310                 1315                 1320             


Val Tyr  Glu Leu Leu Glu Lys  Asp Tyr Arg Met Lys  Arg Pro Glu 
    1325                 1330                 1335             


Gly Cys  Pro Glu Lys Val Tyr  Glu Leu Met Arg Ala  Cys Trp Gln 
    1340                 1345                 1350             


Trp Asn  Pro Ser Asp Arg Pro  Ser Phe Ala Glu Ile  His Gln Ala 
    1355                 1360                 1365             


Phe Glu  Thr Met Phe Gln Glu  Ser Ser Ile Ser Asp  Glu Val Glu 
    1370                 1375                 1380             


Lys Glu  Leu Gly Lys Gln Gly  Val Arg Gly Ala Val  Thr Thr Leu 
    1385                 1390                 1395             


Leu Gln  Ala Pro Glu Leu Pro  Thr Lys Thr Arg Thr  Ser Arg Arg 
    1400                 1405                 1410             


Ala Ala  Glu His Arg Asp Thr  Thr Asp Val Pro Glu  Met Pro His 
    1415                 1420                 1425             


Ser Lys  Gly Gln Gly Glu Ser  Asp Pro Leu Asp His  Glu Pro Ala 
    1430                 1435                 1440             


Val Ser  Pro Leu Leu Pro Arg  Lys Glu Arg Gly Pro  Pro Glu Gly 
    1445                 1450                 1455             


Gly Leu  Asn Glu Asp Glu Arg  Leu Leu Pro Lys Asp  Lys Lys Thr 
    1460                 1465                 1470             


Asn Leu  Phe Ser Ala Leu Ile  Lys Lys Lys Lys Lys  Thr Ala Pro 
    1475                 1480                 1485             


Thr Pro  Pro Lys Arg Ser Ser  Ser Phe Arg Glu Met  Asp Gly Gln 
    1490                 1495                 1500             


Pro Glu  Arg Arg Gly Ala Gly  Glu Glu Glu Gly Arg  Asp Ile Ser 
    1505                 1510                 1515             


Asn Gly  Ala Leu Ala Phe Thr  Pro Leu Asp Thr Ala  Asp Pro Ala 
    1520                 1525                 1530             


Lys Ser  Pro Lys Pro Ser Asn  Gly Ala Gly Val Pro  Asn Gly Ala 
    1535                 1540                 1545             


Leu Arg  Glu Ser Gly Gly Ser  Gly Phe Arg Ser Pro  His Leu Trp 
    1550                 1555                 1560             


Lys Lys  Ser Ser Thr Leu Thr  Ser Ser Arg Leu Ala  Thr Gly Glu 
    1565                 1570                 1575             


Glu Glu  Gly Gly Gly Ser Ser  Ser Lys Arg Phe Leu  Arg Ser Cys 
    1580                 1585                 1590             


Ser Val  Ser Cys Val Pro His  Gly Ala Lys Asp Thr  Glu Trp Arg 
    1595                 1600                 1605             


Ser Val  Thr Leu Pro Arg Asp  Leu Gln Ser Thr Gly  Arg Gln Phe 
    1610                 1615                 1620             


Asp Ser  Ser Thr Phe Gly Gly  His Lys Ser Glu Lys  Pro Ala Leu 
    1625                 1630                 1635             


Pro Arg  Lys Arg Ala Gly Glu  Asn Arg Ser Asp Gln  Val Thr Arg 
    1640                 1645                 1650             


Gly Thr  Val Thr Pro Pro Pro  Arg Leu Val Lys Lys  Asn Glu Glu 
    1655                 1660                 1665             


Ala Ala  Asp Glu Val Phe Lys  Asp Ile Met Glu Ser  Ser Pro Gly 
    1670                 1675                 1680             


Ser Ser  Pro Pro Asn Leu Thr  Pro Lys Pro Leu Arg  Arg Gln Val 
    1685                 1690                 1695             


Thr Val  Ala Pro Ala Ser Gly  Leu Pro His Lys Glu  Glu Ala Trp 
    1700                 1705                 1710             


Lys Gly  Ser Ala Leu Gly Thr  Pro Ala Ala Ala Glu  Pro Val Thr 
    1715                 1720                 1725             


Pro Thr  Ser Lys Ala Gly Ser  Gly Ala Pro Arg Gly  Thr Ser Lys 
    1730                 1735                 1740             


Gly Pro  Ala Glu Glu Ser Arg  Val Arg Arg His Lys  His Ser Ser 
    1745                 1750                 1755             


Glu Ser  Pro Gly Arg Asp Lys  Gly Lys Leu Ser Lys  Leu Lys Pro 
    1760                 1765                 1770             


Ala Pro  Pro Pro Pro Pro Ala  Ala Ser Ala Gly Lys  Ala Gly Gly 
    1775                 1780                 1785             


Lys Pro  Ser Gln Arg Pro Gly  Gln Glu Ala Ala Gly  Glu Ala Val 
    1790                 1795                 1800             


Leu Gly  Ala Lys Thr Lys Ala  Thr Ser Leu Val Asp  Ala Val Asn 
    1805                 1810                 1815             


Ser Asp  Ala Ala Lys Pro Ser  Gln Pro Ala Glu Gly  Leu Lys Lys 
    1820                 1825                 1830             


Pro Val  Leu Pro Ala Thr Pro  Lys Pro His Pro Ala  Lys Pro Ser 
    1835                 1840                 1845             


Gly Thr  Pro Ile Ser Pro Ala  Pro Val Pro Leu Ser  Thr Leu Pro 
    1850                 1855                 1860             


Ser Ala  Ser Ser Ala Leu Ala  Gly Asp Gln Pro Ser  Ser Thr Ala 
    1865                 1870                 1875             


Phe Ile  Pro Leu Ile Ser Thr  Arg Val Ser Leu Arg  Lys Thr Arg 
    1880                 1885                 1890             


Gln Pro  Pro Glu Arg Ala Ser  Gly Ala Ile Thr Lys  Gly Val Val 
    1895                 1900                 1905             


Leu Asp  Ser Thr Glu Ala Leu  Cys Leu Ala Ile Ser  Gly Asn Ser 
    1910                 1915                 1920             


Glu Gln  Met Ala Ser His Ser  Ala Val Leu Glu Ala  Gly Lys Asn 
    1925                 1930                 1935             


Leu Tyr  Thr Phe Cys Val Ser  Tyr Val Asp Ser Ile  Gln Gln Met 
    1940                 1945                 1950             


Arg Asn  Lys Phe Ala Phe Arg  Glu Ala Ile Asn Lys  Leu Glu Asn 
    1955                 1960                 1965             


Asn Leu  Arg Glu Leu Gln Ile  Cys Pro Ala Ser Ala  Gly Ser Gly 
    1970                 1975                 1980             


Pro Ala  Ala Thr Gln Asp Phe  Ser Lys Leu Leu Ser  Ser Val Lys 
    1985                 1990                 1995             


Glu Ile  Ser Asp Ile Val Gln  Arg 
    2000                 2005     


<210>  8
<211>  1530
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Ile Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Asp Glu Gly Ala Phe His Gly Asp Ala Glu Ala Leu Gln Arg Pro 
            420                 425                 430         


Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp 
        435                 440                 445             


Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn 
    450                 455                 460                 


Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu 
465                 470                 475                 480 


Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn 
                485                 490                 495     


Gly Glu Trp Cys Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp Val Pro 
            500                 505                 510         


Ser Asn Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr 
        515                 520                 525             


His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Pro Leu Ser Ser Gly 
    530                 535                 540                 


Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Ser Gln 
545                 550                 555                 560 


Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile 
                565                 570                 575     


Asn Thr Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu Ser Arg Phe 
            580                 585                 590         


Asn Thr Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly 
        595                 600                 605             


Leu Ile Thr Thr Leu His Tyr Pro Ala Pro Lys Arg Asn Lys Pro Thr 
    610                 615                 620                 


Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu Arg Thr 
625                 630                 635                 640 


Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val 
                645                 650                 655     


Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr 
            660                 665                 670         


Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala 
        675                 680                 685             


Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val 
    690                 695                 700                 


Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Ile Glu Phe Met Thr Tyr 
705                 710                 715                 720 


Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu Val Asn 
                725                 730                 735     


Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu 
            740                 745                 750         


Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn 
        755                 760                 765             


Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe Gly Leu 
    770                 775                 780                 


Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys 
785                 790                 795                 800 


Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Lys Phe 
                805                 810                 815     


Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile 
            820                 825                 830         


Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Arg Ser Gln Val 
        835                 840                 845             


Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Lys Arg Pro Glu Gly Cys 
    850                 855                 860                 


Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln Trp Asn Pro 
865                 870                 875                 880 


Ser Asp Arg Pro Ser Phe Ala Glu Ile His Gln Ala Phe Glu Thr Met 
                885                 890                 895     


Phe Gln Glu Ser Ser Ile Ser Asp Glu Val Glu Lys Glu Leu Gly Lys 
            900                 905                 910         


Gln Gly Val Arg Gly Ala Val Thr Thr Leu Leu Gln Ala Pro Glu Leu 
        915                 920                 925             


Pro Thr Lys Thr Arg Thr Ser Arg Arg Ala Ala Glu His Arg Asp Thr 
    930                 935                 940                 


Thr Asp Val Pro Glu Met Pro His Ser Lys Gly Gln Gly Glu Ser Asp 
945                 950                 955                 960 


Pro Leu Asp His Glu Pro Ala Val Ser Pro Leu Leu Pro Arg Lys Glu 
                965                 970                 975     


Arg Gly Pro Pro Glu Gly Gly Leu Asn Glu Asp Glu Arg Leu Leu Pro 
            980                 985                 990         


Lys Asp Lys Lys Thr Asn Leu Phe  Ser Ala Leu Ile Lys  Lys Lys Lys 
        995                 1000                 1005             


Lys Thr  Ala Pro Thr Pro Pro  Lys Arg Ser Ser Ser  Phe Arg Glu 
    1010                 1015                 1020             


Met Asp  Gly Gln Pro Glu Arg  Arg Gly Ala Gly Glu  Glu Glu Gly 
    1025                 1030                 1035             


Arg Asp  Ile Ser Asn Gly Ala  Leu Ala Phe Thr Pro  Leu Asp Thr 
    1040                 1045                 1050             


Ala Asp  Pro Ala Lys Ser Pro  Lys Pro Ser Asn Gly  Ala Gly Val 
    1055                 1060                 1065             


Pro Asn  Gly Ala Leu Arg Glu  Ser Gly Gly Ser Gly  Phe Arg Ser 
    1070                 1075                 1080             


Pro His  Leu Trp Lys Lys Ser  Ser Thr Leu Thr Ser  Ser Arg Leu 
    1085                 1090                 1095             


Ala Thr  Gly Glu Glu Glu Gly  Gly Gly Ser Ser Ser  Lys Arg Phe 
    1100                 1105                 1110             


Leu Arg  Ser Cys Ser Val Ser  Cys Val Pro His Gly  Ala Lys Asp 
    1115                 1120                 1125             


Thr Glu  Trp Arg Ser Val Thr  Leu Pro Arg Asp Leu  Gln Ser Thr 
    1130                 1135                 1140             


Gly Arg  Gln Phe Asp Ser Ser  Thr Phe Gly Gly His  Lys Ser Glu 
    1145                 1150                 1155             


Lys Pro  Ala Leu Pro Arg Lys  Arg Ala Gly Glu Asn  Arg Ser Asp 
    1160                 1165                 1170             


Gln Val  Thr Arg Gly Thr Val  Thr Pro Pro Pro Arg  Leu Val Lys 
    1175                 1180                 1185             


Lys Asn  Glu Glu Ala Ala Asp  Glu Val Phe Lys Asp  Ile Met Glu 
    1190                 1195                 1200             


Ser Ser  Pro Gly Ser Ser Pro  Pro Asn Leu Thr Pro  Lys Pro Leu 
    1205                 1210                 1215             


Arg Arg  Gln Val Thr Val Ala  Pro Ala Ser Gly Leu  Pro His Lys 
    1220                 1225                 1230             


Glu Glu  Ala Trp Lys Gly Ser  Ala Leu Gly Thr Pro  Ala Ala Ala 
    1235                 1240                 1245             


Glu Pro  Val Thr Pro Thr Ser  Lys Ala Gly Ser Gly  Ala Pro Arg 
    1250                 1255                 1260             


Gly Thr  Ser Lys Gly Pro Ala  Glu Glu Ser Arg Val  Arg Arg His 
    1265                 1270                 1275             


Lys His  Ser Ser Glu Ser Pro  Gly Arg Asp Lys Gly  Lys Leu Ser 
    1280                 1285                 1290             


Lys Leu  Lys Pro Ala Pro Pro  Pro Pro Pro Ala Ala  Ser Ala Gly 
    1295                 1300                 1305             


Lys Ala  Gly Gly Lys Pro Ser  Gln Arg Pro Gly Gln  Glu Ala Ala 
    1310                 1315                 1320             


Gly Glu  Ala Val Leu Gly Ala  Lys Thr Lys Ala Thr  Ser Leu Val 
    1325                 1330                 1335             


Asp Ala  Val Asn Ser Asp Ala  Ala Lys Pro Ser Gln  Pro Ala Glu 
    1340                 1345                 1350             


Gly Leu  Lys Lys Pro Val Leu  Pro Ala Thr Pro Lys  Pro His Pro 
    1355                 1360                 1365             


Ala Lys  Pro Ser Gly Thr Pro  Ile Ser Pro Ala Pro  Val Pro Leu 
    1370                 1375                 1380             


Ser Thr  Leu Pro Ser Ala Ser  Ser Ala Leu Ala Gly  Asp Gln Pro 
    1385                 1390                 1395             


Ser Ser  Thr Ala Phe Ile Pro  Leu Ile Ser Thr Arg  Val Ser Leu 
    1400                 1405                 1410             


Arg Lys  Thr Arg Gln Pro Pro  Glu Arg Ala Ser Gly  Ala Ile Thr 
    1415                 1420                 1425             


Lys Gly  Val Val Leu Asp Ser  Thr Glu Ala Leu Cys  Leu Ala Ile 
    1430                 1435                 1440             


Ser Gly  Asn Ser Glu Gln Met  Ala Ser His Ser Ala  Val Leu Glu 
    1445                 1450                 1455             


Ala Gly  Lys Asn Leu Tyr Thr  Phe Cys Val Ser Tyr  Val Asp Ser 
    1460                 1465                 1470             


Ile Gln  Gln Met Arg Asn Lys  Phe Ala Phe Arg Glu  Ala Ile Asn 
    1475                 1480                 1485             


Lys Leu  Glu Asn Asn Leu Arg  Glu Leu Gln Ile Cys  Pro Ala Ser 
    1490                 1495                 1500             


Ala Gly  Ser Gly Pro Ala Ala  Thr Gln Asp Phe Ser  Lys Leu Leu 
    1505                 1510                 1515             


Ser Ser  Val Lys Glu Ile Ser  Asp Ile Val Gln Arg  
    1520                 1525                 1530 


<210>  9
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  9

Met His Lys Tyr Lys Lys Gln Phe Arg Tyr Glu Ser Gln Leu Gln Met 
1               5                   10                  15      


Val Gln Val Thr Gly Ser Ser Asp Asn Glu Tyr Phe Tyr Val Asp Phe 
            20                  25                  30          


Arg Glu Tyr Glu Tyr Asp Leu Lys Trp Glu Phe Pro Arg Glu Asn Leu 
        35                  40                  45              


Glu Phe Gly Lys Val Leu Gly Ser Gly Ala Phe Gly Lys Val Met Asn 
    50                  55                  60                  


Ala Thr Ala Tyr Gly Ile Ser Lys Thr Gly Val Ser Ile Gln Val Ala 
65                  70                  75                  80  


Val Lys Met Leu Lys Glu Lys Ala Asp Ser Ser Glu Arg Glu Ala Leu 
                85                  90                  95      


Met Ser Glu Leu Lys Met Met Thr Gln Leu Gly Ser His Glu Asn Ile 
            100                 105                 110         


Val Asn Leu Leu Gly Ala Cys Thr Leu Ser Gly Pro Ile Tyr Leu Ile 
        115                 120                 125             


Phe Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Tyr Leu Arg Ser Lys 
    130                 135                 140                 


Arg Glu Lys Phe His Arg Thr Trp Thr Glu Ile Phe Lys Glu His Asn 
145                 150                 155                 160 


Phe Ser Phe Tyr Pro Thr Phe Gln Ser His Pro Asn Ser Ser Met Pro 
                165                 170                 175     


Gly Ser Arg Glu Val Gln Ile His Pro Asp Ser Asp Gln Ile Ser Gly 
            180                 185                 190         


Leu His Gly Asn Ser Phe His Ser Glu Asp Glu Ile Glu Tyr Glu Asn 
        195                 200                 205             


Gln Lys Arg Leu Glu Glu Glu Glu Asp Leu Asn Val Leu Thr Phe Glu 
    210                 215                 220                 


Asp Leu Leu Cys Phe Ala Tyr Gln Val Ala Lys Gly Met Glu Phe Leu 
225                 230                 235                 240 


Glu Phe Lys Ser Cys Val His Arg Asp Leu Ala Ala Arg Asn Val Leu 
                245                 250                 255     


Val Thr His Gly Lys Val Val Lys Ile Cys Asp Phe Gly Leu Ala Arg 
            260                 265                 270         


Tyr Ile Met Ser Asp Ser Asn Tyr Val Val Arg Gly Asn Ala Arg Leu 
        275                 280                 285             


Pro Val Lys Trp Met Ala Pro Glu Ser Leu Phe Glu Gly Ile Tyr Thr 
    290                 295                 300                 


Ile Lys Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu Ile Phe 
305                 310                 315                 320 


Ser Leu Gly Val Asn Pro Tyr Pro Gly Ile Pro Val Asp Ala Asn Phe 
                325                 330                 335     


Tyr Lys Leu Ile Gln Asn Gly Phe Lys Met Asp Gln Pro Phe Tyr Ala 
            340                 345                 350         


Thr Glu Glu Ile Tyr Ile Ile Met Gln Ser Cys Trp Ala Phe Asp Ser 
        355                 360                 365             


Arg Lys Arg Pro Ser Phe Pro Asn Leu Thr Ser Phe Leu Gly Cys Gln 
    370                 375                 380                 


Leu Ala Asp Ala Glu Glu Ala Met Tyr Gln Asn Val Lys Gly Val Glu 
385                 390                 395                 400 


Ala Cys Gln Leu Gly Thr Asp Asp Tyr Asp Ile Pro Thr Thr His His 
                405                 410                 415     


His His His His 
            420 


<210>  10
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Lys Cys Gly Arg Arg Asn Lys Phe Gly Ile Asn Arg Pro Ala Val 
1               5                   10                  15      


Leu Ala Pro Glu Asp Gly Leu Ala Met Ser Leu His Phe Met Thr Leu 
            20                  25                  30          


Gly Gly Ser Ser Leu Ser Pro Thr Glu Gly Lys Gly Ser Gly Leu Gln 
        35                  40                  45              


Gly His Ile Ile Glu Asn Pro Gln Tyr Phe Ser Asp Ala Cys Val His 
    50                  55                  60                  


His Ile Lys Arg Arg Asp Ile Val Leu Lys Trp Glu Leu Gly Glu Gly 
65                  70                  75                  80  


Ala Phe Gly Lys Val Phe Leu Ala Glu Cys His Asn Leu Leu Pro Glu 
                85                  90                  95      


Gln Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Glu Ala Ser Glu 
            100                 105                 110         


Ser Ala Arg Gln Asp Phe Gln Arg Glu Ala Glu Leu Leu Thr Met Leu 
        115                 120                 125             


Gln His Gln His Ile Val Arg Phe Phe Gly Val Cys Thr Glu Gly Arg 
    130                 135                 140                 


Pro Leu Leu Met Val Phe Glu Tyr Met Arg His Gly Asp Leu Asn Arg 
145                 150                 155                 160 


Phe Leu Arg Ser His Gly Pro Asp Ala Lys Leu Leu Ala Gly Gly Glu 
                165                 170                 175     


Asp Val Ala Pro Gly Pro Leu Gly Leu Gly Gln Leu Leu Ala Val Ala 
            180                 185                 190         


Ser Gln Val Ala Ala Gly Met Val Tyr Leu Ala Gly Leu His Phe Val 
        195                 200                 205             


His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Gln Gly Leu Val 
    210                 215                 220                 


Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Ile Tyr Ser Thr Asp 
225                 230                 235                 240 


Tyr Tyr Arg Val Gly Gly Arg Thr Met Leu Pro Ile Arg Trp Met Pro 
                245                 250                 255     


Pro Glu Ser Ile Leu Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val Trp 
            260                 265                 270         


Ser Phe Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln Pro 
        275                 280                 285             


Trp Tyr Gln Leu Ser Asn Thr Glu Ala Ile Asp Cys Ile Thr Gln Gly 
    290                 295                 300                 


Arg Glu Leu Glu Arg Pro Arg Ala Cys Pro Pro Glu Val Tyr Ala Ile 
305                 310                 315                 320 


Met Arg Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg His Ser Ile Lys 
                325                 330                 335     


Asp Val His Ala Arg Leu Gln Ala Leu Ala Gln Ala Pro Pro Val Tyr 
            340                 345                 350         


Leu Asp Val Leu Gly Lys Gly Val Glu Ala Cys Gln Leu Gly Thr Asp 
        355                 360                 365             


Asp Tyr Asp Ile Pro Thr Thr His His His His His His 
    370                 375                 380     


<210>  11
<211>  534
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Val Pro Arg 
    210                 215                 220                 


His Asn Gln Thr Ser Leu Tyr Lys Lys Ala Gly Ser Ala Ala Ala Leu 
225                 230                 235                 240 


Phe Asn Phe Lys Lys Glu Pro Phe Thr Pro Val Leu Asp Trp Asn Asp 
                245                 250                 255     


Ile Lys Phe Gln Asp Val Ile Gly Glu Gly Asn Phe Gly Gln Val Leu 
            260                 265                 270         


Lys Ala Arg Ile Lys Lys Asp Gly Leu Arg Met Asp Ala Ala Ile Lys 
        275                 280                 285             


Arg Met Lys Glu Tyr Ala Ser Lys Asp Asp His Arg Asp Phe Ala Gly 
    290                 295                 300                 


Glu Leu Glu Val Leu Cys Lys Leu Gly His His Pro Asn Ile Ile Asn 
305                 310                 315                 320 


Leu Leu Gly Ala Cys Glu His Arg Gly Tyr Leu Tyr Leu Ala Ile Glu 
                325                 330                 335     


Tyr Ala Pro His Gly Asn Leu Leu Asp Phe Leu Arg Lys Ser Arg Val 
            340                 345                 350         


Leu Glu Thr Asp Pro Ala Phe Ala Ile Ala Asn Ser Thr Ala Ser Thr 
        355                 360                 365             


Leu Ser Ser Gln Gln Leu Leu His Phe Ala Ala Asp Val Ala Arg Gly 
    370                 375                 380                 


Met Asp Tyr Leu Ser Gln Lys Gln Phe Ile His Arg Asp Leu Ala Ala 
385                 390                 395                 400 


Arg Asn Ile Leu Val Gly Glu Asn Tyr Val Ala Lys Ile Ala Asp Phe 
                405                 410                 415     


Gly Leu Ser Arg Gly Gln Glu Val Tyr Val Lys Lys Thr Met Gly Arg 
            420                 425                 430         


Leu Pro Val Arg Trp Met Ala Ile Glu Ser Leu Asn Tyr Ser Val Tyr 
        435                 440                 445             


Thr Thr Asn Ser Asp Val Trp Ser Tyr Gly Val Leu Leu Trp Glu Ile 
    450                 455                 460                 


Val Ser Leu Gly Gly Thr Pro Tyr Cys Gly Met Thr Cys Ala Glu Leu 
465                 470                 475                 480 


Tyr Glu Lys Leu Pro Gln Gly Tyr Arg Leu Glu Lys Pro Leu Asn Cys 
                485                 490                 495     


Asp Asp Glu Val Tyr Asp Leu Met Arg Gln Cys Trp Arg Glu Lys Pro 
            500                 505                 510         


Tyr Glu Arg Pro Ser Phe Ala Gln Ile Leu Val Ser Leu Asn Arg Met 
        515                 520                 525             


Leu Glu Glu Arg Lys Thr 
    530                 


<210>  12
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Ala Ile Tyr Ala Ala Pro Phe Ala Lys Lys Lys 
1               5                   10          




