                         SEQUENCE LISTING

<110>  INSTITUT PASTEUR
 
<120>  POLYPEPTIDES TARGETING GLYCOSYLATED MUC2 PROTEINS, METHODS OF 
       SYNTHESIS, THEIR NUCLEIC ACIDS AND USES THEREOF

<130>  B09598A - AD/AFL/KN

<140>  PCT/EP XXXXXX
<141>  2012-09-07

<150>  EP 11290403.2
<151>  2011-09-09

<160>  83    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence


<220>
<221>  source
<222>  (1)..(15)
<223>  Consensus sequence

<220>
<221>  DOMAIN
<222>  (2)..(2)
<223>  Xaa represents any amino-acid

<220>
<221>  DOMAIN
<222>  (4)..(4)
<223>  Xaa represents any amino-acid

<220>
<221>  DOMAIN
<222>  (5)..(5)
<223>  Xaa represents any amino-acid

<220>
<221>  DOMAIN
<222>  (6)..(6)
<223>  Xaa represents a fragment of 2 to 33 of any amino-acid

<220>
<221>  DOMAIN
<222>  (9)..(9)
<223>  Xaa represents a fragment of 2 to 11 of any amino-acid

<220>
<221>  DOMAIN
<222>  (10)..(10)
<223>  Phe can be replaced by Tyr

<220>
<221>  DOMAIN
<222>  (12)..(12)
<223>  Xaa represents a fragment of 1 to 2 of any amino-acid

<220>
<221>  DOMAIN
<222>  (14)..(14)
<223>  Xaa represents a fragment of 1 to 3 of any amino-acid

<400>  1

Val Xaa Tyr Xaa Asp Xaa Gly Tyr Xaa Phe Asp Xaa Asp Xaa Gln 
1               5                   10                  15  


<210>  2
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence


<220>
<221>  source
<222>  (1)..(25)
<223>  Consensus sequence

<220>
<221>  DOMAIN
<222>  (2)..(2)
<223>  Xaa represents any amino-acid

<220>
<221>  DOMAIN
<222>  (4)..(4)
<223>  Xaa represents any amino-acid

<220>
<221>  DOMAIN
<222>  (5)..(5)
<223>  Asp can be replaced by Asn

<220>
<221>  DOMAIN
<222>  (6)..(6)
<223>  Xaa represents a fragment of 1 to 23 amino-acids

<220>
<221>  DOMAIN
<222>  (8)..(8)
<223>  Ser can be replaced by Thr

<220>
<221>  DOMAIN
<222>  (10)..(10)
<223>  Xaa represents a fragment of 1 to 10 amino-acids

<220>
<221>  DOMAIN
<222>  (13)..(13)
<223>  Xaa represents any amino-acid

<220>
<221>  DOMAIN
<222>  (15)..(15)
<223>  Xaa represents a fragment of 1 to 10 amino-acids

<220>
<221>  DOMAIN
<222>  (16)..(16)
<223>  Phe can be replaced by Tyr

<220>
<221>  DOMAIN
<222>  (18)..(18)
<223>  Xaa represents a fragment of 1 to 2 amino-acids

<220>
<221>  DOMAIN
<222>  (20)..(20)
<223>  Xaa represents a fragment of 1 to 3 amino-acids

<220>
<221>  DOMAIN
<222>  (21)..(21)
<223>  Xaa represents any amino-acid

<220>
<221>  DOMAIN
<222>  (22)..(22)
<223>  Xaa represents any amino-acid

<220>
<221>  DOMAIN
<222>  (23)..(23)
<223>  Xaa represents any amino-acid

<400>  2

Val Xaa Tyr Xaa Asp Xaa Tyr Ser Thr Xaa Gly Tyr Xaa Leu Xaa Phe 
1               5                   10                  15      


Asp Xaa Asp Xaa Gln Xaa Xaa Xaa Val 
            20                  25  


<210>  3
<211>  70
<212>  PRT
<213>  Lactobacillus reuteri


<220>
<221>  source
<222>  (1)..(70)
<223>  MUB70

<400>  3

Val His Val Gln Tyr Ile Asp Gly Glu Thr Asp Gln Met Leu Arg Gln 
1               5                   10                  15      


Asp Asp Leu Asp Gly Tyr Thr Asp Glu Thr Ile Pro Tyr Ser Thr Ala 
            20                  25                  30          


Glu Gly Ile Lys Lys Phe Glu Gly Asp Gly Tyr Glu Leu Phe Lys Asp 
        35                  40                  45              


Asn Phe Pro Ala Gly Glu Lys Phe Asp Asn Asp Asp Thr Asn Asp Gln 
    50                  55                  60                  


Phe Tyr Thr Val Ile Phe 
65                  70  


<210>  4
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized MUB70


<220>
<221>  source
<222>  (1)..(71)
<223>  Synthesized MUB70

<400>  4

Cys Val His Val Gln Tyr Ile Asp Gly Glu Thr Asp Gln Met Leu Arg 
1               5                   10                  15      


Gln Asp Asp Leu Asp Gly Tyr Thr Asp Glu Thr Ile Pro Tyr Ser Thr 
            20                  25                  30          


Ala Glu Gly Ile Lys Lys Phe Glu Gly Asp Gly Tyr Glu Leu Phe Lys 
        35                  40                  45              


Asp Asn Phe Pro Ala Gly Glu Lys Phe Asp Asn Asp Asp Thr Asn Asp 
    50                  55                  60                  


Gln Phe Tyr Thr Val Ile Phe 
65                  70      


<210>  5
<211>  180
<212>  PRT
<213>  Lactobacillus reuteri


<220>
<221>  source
<222>  (1)..(180)
<223>  MUB200

<400>  5

Ile Asn Val Val Tyr Val Ala Asp Thr Gln Glu Ala Ala Ile Ser Phe 
1               5                   10                  15      


Tyr Asp Glu Thr Asp His Lys Pro Leu Asn Asp Gln Thr Ile Gln Leu 
            20                  25                  30          


Thr Gly Lys Thr Gly Glu Lys Ile Ser His Thr Glu Ala Asn Gln Thr 
        35                  40                  45              


Leu Ala Lys Leu Gly Lys Gln Gly Tyr Val Val Asp Gln Asn Thr Phe 
    50                  55                  60                  


Ala Asp Asp Ala Thr Tyr Asp Asn Asp Thr Gln Ala Pro Gln Glu Phe 
65                  70                  75                  80  


Thr Ile Tyr Leu Lys His Asp Thr Thr His Thr Asp Ala Thr Ser Ser 
                85                  90                  95      


Lys Ala Asp Gln Lys Thr Val Ser Glu Thr Ile His Tyr Val Tyr Lys 
            100                 105                 110         


Asp Gly Val Asn Ala Asn Lys Pro Val Ala Asp Asp Ala Asn Thr Thr 
        115                 120                 125             


Val Thr Phe Lys Arg Gly Tyr Thr Thr Asp Lys Val Thr Gly Lys Ile 
    130                 135                 140                 


Val Ser Tyr Asp Pro Trp Thr Val Asp Gly Lys Gln Ala Asp Ser Lys 
145                 150                 155                 160 


Thr Phe Asp Ala Val Lys Ser Pro Val Ile Ala Gly Tyr Thr Ala Asp 
                165                 170                 175     


Gln Ala Glu Val 
            180 


<210>  6
<211>  183
<212>  PRT
<213>  Lactobacillus reuteri


<220>
<221>  source
<222>  (1)..(183)
<223>  MUB200

<400>  6

Thr Val Tyr Tyr Thr Ala Asp Thr Gln Glu Ala Ala Ile Asn Phe Tyr 
1               5                   10                  15      


Asp Glu Thr Gly His Lys Leu Leu Asp Asn Gln Thr Ile His Leu Thr 
            20                  25                  30          


Gly Lys Thr Gly Glu Lys Val Asp Arg Thr Gln Ala Asp Gln Thr Leu 
        35                  40                  45              


Ala Asp Leu Val Lys Gln Gly Tyr Val Leu Asp Lys Glu Asn Thr Ala 
    50                  55                  60                  


Lys Ala Phe Pro Ala Asp Ala Val Tyr Asp Asn Asn Asp Gln Thr Pro 
65                  70                  75                  80  


Gln Glu Phe Thr Ile Tyr Leu Lys His Gly Thr Thr His Thr Asp Ala 
                85                  90                  95      


Thr Ser Ser Lys Ala Asp Gln Lys Thr Val Ser Glu Thr Ile His Tyr 
            100                 105                 110         


Val Tyr Lys Asp Gly Val Asn Ala Asn Lys Pro Val Ala Asp Asp Ala 
        115                 120                 125             


Asn Thr Thr Val Thr Phe Lys Arg Gly Tyr Thr Thr Asp Lys Val Thr 
    130                 135                 140                 


Gly Lys Ile Val Ser Tyr Asp Pro Trp Thr Val Asp Gly Lys Gln Ala 
145                 150                 155                 160 


Asp Ser Lys Thr Phe Asp Ala Val Lys Ser Pro Val Ile Ala Gly Tyr 
                165                 170                 175     


Thr Ala Asp Gln Ala Glu Val 
            180             


<210>  7
<211>  174
<212>  PRT
<213>  Lactobacillus reuteri


<220>
<221>  source
<222>  (1)..(174)
<223>  MUB200

<400>  7

Thr Val Tyr Tyr Thr Ala Asp Thr Gln Glu Ala Ala Ile Asn Phe Tyr 
1               5                   10                  15      


Asp Glu Thr Gly His Lys Leu Leu Asp Asn Gln Thr Ile His Leu Thr 
            20                  25                  30          


Gly Lys Thr Gly Glu Lys Val Asp Arg Thr Gln Ala Asp Gln Thr Leu 
        35                  40                  45              


Ala Glu Leu Glu Lys Gln Gly Tyr Val Leu Asp Glu Asn Asn Thr Lys 
    50                  55                  60                  


Leu Gly Phe Pro Ser Asn Ala Ala Tyr Asp Asp Asp Asp Val Lys Pro 
65                  70                  75                  80  


Gln Glu Phe Thr Ile Tyr Leu Lys His Gly Met Thr His Thr Asp Ala 
                85                  90                  95      


Thr Asp Lys Asn Ala Glu Gln Lys Ile Val Thr Glu Thr Ile His Tyr 
            100                 105                 110         


Val Tyr Glu Asn Asn Gln Thr Ala Lys Thr Asp Tyr Thr Ser Ala Val 
        115                 120                 125             


Asp Phe Lys Arg Gly Tyr Thr Thr Asp Asn Val Thr His Lys Ile Ile 
    130                 135                 140                 


Ser Tyr Asp Pro Trp Met Val Ser Ser Lys Lys Phe Gly Phe Val Lys 
145                 150                 155                 160 


Ser Pro Ala Ile Glu Gly Tyr Thr Pro Asn His Ser Gln Ile 
                165                 170                 


<210>  8
<211>  172
<212>  PRT
<213>  Lactobacillus reuteri


<220>
<221>  source
<222>  (1)..(172)
<223>  MUB200

<400>  8

Thr Val Val Tyr Val Gly Asn Ala Gln Glu Ala Gln Ala Ile Phe Tyr 
1               5                   10                  15      


Asp Glu Thr Thr Gly Lys Glu Ile Ser Gly Thr Arg Glu Ile Ala Thr 
            20                  25                  30          


Gly Lys Thr Asp Glu Thr Ile Ser Phe Thr Lys Asp Pro Asn Glu Val 
        35                  40                  45              


Val Lys Glu Leu Glu Lys Gln Gly Tyr Val Phe Asp Lys Asp Asn Ala 
    50                  55                  60                  


Lys Asn Asn Val Phe Val Ala Gly Thr Ala Tyr Asp Lys Asn Ser Glu 
65                  70                  75                  80  


Val His Gln Tyr Phe Lys Tyr Tyr Leu Lys His Gly His Ala Thr Val 
                85                  90                  95      


Thr Pro Asp Gln Asp Pro Gln Lys Gly Gln Lys Thr Val Thr Gln Thr 
            100                 105                 110         


Ile Lys Tyr Glu Tyr Ala Asp Gly Thr Ala Thr Gly Leu Ala Asp Asn 
        115                 120                 125             


Val Gln Thr Leu Thr Phe Lys Arg Thr Gly Asp Lys Asp Leu Val Thr 
    130                 135                 140                 


His Glu Val Thr Trp Pro Asp Trp Ser Thr Val Ala Gly Gln Gln Thr 
145                 150                 155                 160 


Ser Val Val Thr Ser Pro Ala Leu Lys Gly Tyr Thr 
                165                 170         


<210>  9
<211>  183
<212>  PRT
<213>  Lactobacillus reuteri


<220>
<221>  source
<222>  (1)..(183)
<223>  MUB200

<400>  9

Thr Tyr Val Val Lys Tyr Asn Ala Asp Val Gln His Ala Val Ile Asn 
1               5                   10                  15      


Tyr Ile Asp Gly Glu Ser Asp Glu Ile Leu His Thr Asp Lys Val Asn 
            20                  25                  30          


Gly His Ser Asp Glu Lys Ile Asn Tyr Ser Thr Ala Asp Met Ile Lys 
        35                  40                  45              


Gln Leu Glu Ala Lys Gly Tyr Glu Leu Phe Lys Asp Asn Phe Pro Ala 
    50                  55                  60                  


Gly Glu Lys Phe Asp Asn Asp Asp Thr Asn Asp Gln Phe Tyr Thr Val 
65                  70                  75                  80  


Ile Phe Lys His His Arg Glu Asn Val Asp Pro Asn His Ser Ser Ala 
                85                  90                  95      


Asp Gly Thr Lys Gly Thr Lys Thr Leu Thr Glu Thr Val His Tyr Lys 
            100                 105                 110         


Tyr Ala Asn Gly Thr Lys Ala Ala Glu Asp Gln Thr Ala Gln Val Thr 
        115                 120                 125             


Phe Thr Arg Asn Gly Val Leu Asp Asp Val Thr Gly Ile Val Ala Trp 
    130                 135                 140                 


Gly Lys Trp Asn Glu Ala Ser Gln Ser Tyr Lys Ala Leu Thr Ser Pro 
145                 150                 155                 160 


Thr Ile Ala Gly Tyr Ala Pro Ser Glu Ala Val Val Lys Arg Ser Ser 
                165                 170                 175     


Asn Ser Asp Ala Glu Gln Gly 
            180             


<210>  10
<211>  183
<212>  PRT
<213>  Lactobacillus reuteri


<220>
<221>  source
<222>  (1)..(183)
<223>  MUB200

<400>  10

Thr Leu Thr Val Ile Tyr Thr Ala Asp Ala Gln Lys Val His Val Gln 
1               5                   10                  15      


Tyr Ile Asp Gly Glu Thr Asp Gln Met Leu Arg Gln Asp Asp Leu Asp 
            20                  25                  30          


Gly Tyr Thr Asp Glu Thr Ile Pro Tyr Ser Thr Ala Glu Gly Ile Lys 
        35                  40                  45              


Lys Phe Glu Gly Asp Gly Tyr Glu Leu Phe Lys Asp Asn Phe Pro Ala 
    50                  55                  60                  


Gly Glu Lys Phe Asp Asn Asp Asp Lys Asn Asp Gln Thr Tyr Thr Val 
65                  70                  75                  80  


Ile Phe Lys His His Arg Glu Asn Val Asp Pro Asn His Ser Ser Ala 
                85                  90                  95      


Asp Gly Thr Lys Gly Thr Lys Thr Leu Thr Glu Thr Val His Tyr Lys 
            100                 105                 110         


Tyr Ala Asp Gly Thr Lys Ala Ala Glu Asp Gln Thr Ala Gln Val Thr 
        115                 120                 125             


Phe Thr Arg Asn Gly Val Leu Asp Asp Val Thr Gly Ile Val Ala Trp 
    130                 135                 140                 


Gly Lys Trp Asn Glu Ala Ser Gln Ser Tyr Lys Ala Leu Thr Ser Pro 
145                 150                 155                 160 


Thr Ile Ala Gly Tyr Thr Pro Ser Glu Ala Val Val Lys Arg Ser Ser 
                165                 170                 175     


Asn Ser Asp Ala Glu Gln Gly 
            180             


<210>  11
<211>  183
<212>  PRT
<213>  Lactobacillus reuteri


<220>
<221>  source
<222>  (1)..(183)
<223>  MUB200

<400>  11

Thr Leu Thr Val Ile Tyr Thr Ala Asp Ala Gln Lys Val His Val Gln 
1               5                   10                  15      


Tyr Ile Asp Gly Glu Thr Asp Gln Met Leu Arg Gln Asp Asp Leu Asp 
            20                  25                  30          


Gly Tyr Thr Asp Glu Thr Ile Pro Tyr Ser Thr Ala Glu Gly Ile Lys 
        35                  40                  45              


Lys Phe Glu Gly Asp Gly Tyr Glu Leu Phe Lys Asp Asn Phe Pro Ala 
    50                  55                  60                  


Gly Glu Lys Phe Asp Asn Asp Asp Thr Asn Asp Gln Phe Tyr Thr Val 
65                  70                  75                  80  


Ile Phe Lys His His Arg Glu Asn Val Asp Pro Asn His Ser Ser Ala 
                85                  90                  95      


Asp Gly Thr Lys Gly Thr Lys Thr Leu Thr Glu Thr Val His Tyr Lys 
            100                 105                 110         


Tyr Ala Asn Gly Thr Lys Ala Ala Glu Asp Gln Thr Ala Gln Val Thr 
        115                 120                 125             


Phe Thr Arg Asn Gly Val Leu Asp Asp Val Thr Gly Ile Val Ala Trp 
    130                 135                 140                 


Gly Lys Trp Asn Glu Ala Ser Gln Ser Tyr Lys Ala Leu Thr Ser Pro 
145                 150                 155                 160 


Thr Ile Ala Gly Tyr Ala Pro Ser Glu Ala Val Val Lys Arg Ser Ser 
                165                 170                 175     


Asn Ser Asp Ala Glu Gln Gly 
            180             


<210>  12
<211>  183
<212>  PRT
<213>  Lactobacillus reuteri


<220>
<221>  source
<222>  (1)..(183)
<223>  MUB200

<400>  12

Thr Leu Thr Val Ile Tyr Thr Ala Asp Ala Gln Lys Val His Val Gln 
1               5                   10                  15      


Tyr Ile Asp Gly Glu Thr Asp Gln Met Leu Arg Gln Asp Asp Leu Asp 
            20                  25                  30          


Gly Tyr Thr Asp Glu Thr Ile Pro Tyr Ser Thr Ala Glu Gly Ile Lys 
        35                  40                  45              


Lys Phe Glu Gly Asp Gly Tyr Glu Leu Phe Lys Asp Asn Phe Pro Ala 
    50                  55                  60                  


Gly Glu Lys Phe Asp Asn Asp Asp Lys Asn Asp Gln Thr Tyr Thr Val 
65                  70                  75                  80  


Ile Phe Lys His His Arg Glu Asn Val Asp Pro Asn His Ser Ser Ala 
                85                  90                  95      


Asp Gly Thr Lys Gly Thr Lys Thr Leu Thr Glu Thr Val His Tyr Lys 
            100                 105                 110         


Tyr Ala Asp Gly Thr Lys Ala Ala Glu Asp Gln Thr Ala Gln Val Thr 
        115                 120                 125             


Phe Thr Arg Asn Gly Val Leu Asp Asp Val Thr Gly Ile Val Ala Trp 
    130                 135                 140                 


Gly Lys Trp Asn Glu Ala Ser Gln Ser Tyr Lys Ala Leu Thr Ser Pro 
145                 150                 155                 160 


Thr Ile Ala Gly Tyr Thr Pro Ser Glu Ala Val Val Lys Arg Ser Ser 
                165                 170                 175     


Asn Ser Asp Ala Glu Gln Gly 
            180             


<210>  13
<211>  183
<212>  PRT
<213>  Lactobacillus reuteri


<220>
<221>  source
<222>  (1)..(183)
<223>  MUB200

<400>  13

Thr Leu Thr Val Ile Tyr Thr Ala Asp Ala Gln Lys Val His Val Gln 
1               5                   10                  15      


Tyr Ile Asp Gly Glu Thr Asp Gln Met Leu Arg Gln Asp Asp Leu Asp 
            20                  25                  30          


Gly Tyr Thr Asp Glu Thr Ile Pro Tyr Ser Thr Ala Glu Gly Ile Lys 
        35                  40                  45              


Lys Phe Glu Gly Asp Gly Tyr Glu Leu Phe Lys Asp Asn Phe Pro Ala 
    50                  55                  60                  


Gly Glu Lys Phe Asp Asn Asp Asp Lys Asn Asp Gln Thr Tyr Thr Val 
65                  70                  75                  80  


Ile Phe Lys His His Arg Glu Asn Val Asp Pro Asn His Ser Ser Ala 
                85                  90                  95      


Asp Gly Thr Lys Gly Thr Lys Thr Leu Thr Glu Thr Val His Tyr Lys 
            100                 105                 110         


Tyr Ala Asp Gly Thr Lys Ala Ala Glu Asp Gln Thr Ala Gln Val Thr 
        115                 120                 125             


Phe Thr Arg Asn Gly Val Leu Asp Asp Val Thr Gly Ile Val Ala Trp 
    130                 135                 140                 


Gly Lys Trp Asn Glu Ala Ser Gln Ser Tyr Lys Ala Leu Thr Ser Pro 
145                 150                 155                 160 


Thr Ile Ala Gly Tyr Thr Pro Ser Glu Ala Val Val Lys Arg Ser Ser 
                165                 170                 175     


Asn Ser Asp Ala Glu Gln Gly 
            180             


<210>  14
<211>  183
<212>  PRT
<213>  Lactobacillus reuteri


<220>
<221>  source
<222>  (1)..(183)
<223>  MUB200

<400>  14

Thr Leu Thr Val Ile Tyr Thr Ala Asp Ala Gln Lys Val His Val Gln 
1               5                   10                  15      


Tyr Ile Asp Gly Glu Thr Asp Gln Met Leu Arg Gln Asp Asp Leu Asp 
            20                  25                  30          


Gly Tyr Thr Asp Glu Thr Ile Pro Tyr Ser Thr Ala Glu Gly Ile Lys 
        35                  40                  45              


Lys Phe Glu Gly Asp Gly Tyr Glu Leu Phe Lys Asp Asn Phe Pro Ala 
    50                  55                  60                  


Gly Glu Lys Phe Asp Asn Asp Asp Lys Thr Asp Gln Thr Tyr Thr Val 
65                  70                  75                  80  


Ile Phe Lys His His Arg Glu Asn Val Asp Pro Asn His Ser Ser Ala 
                85                  90                  95      


Asp Gly Thr Lys Gly Thr Lys Thr Leu Thr Glu Thr Val His Tyr Lys 
            100                 105                 110         


Tyr Ala Asp Gly Thr Lys Ala Ala Glu Asp Gln Thr Ala Gln Val Thr 
        115                 120                 125             


Phe Thr Arg Asn Gly Val Leu Asp Asp Val Thr Gly Ile Val Ala Trp 
    130                 135                 140                 


Gly Lys Trp Asn Glu Ala Ser Gln Ser Tyr Lys Ala Leu Thr Ser Pro 
145                 150                 155                 160 


Thr Ile Ala Gly Tyr Thr Pro Ser Glu Ala Val Val Lys Arg Ser Ser 
                165                 170                 175     


Asn Ser Asp Ala Glu Gln Gly 
            180             


<210>  15
<211>  183
<212>  PRT
<213>  Lactobacillus reuteri


<220>
<221>  source
<222>  (1)..(183)
<223>  MUB200

<400>  15

Thr Leu Thr Val Ile Tyr Thr Ala Asp Ala Gln Thr Ala Tyr Val Lys 
1               5                   10                  15      


Tyr Val Asp Asp Thr Thr Gly Glu Thr Leu Arg Gln Asp Asp Leu His 
            20                  25                  30          


Gly Tyr Thr Asp Glu Thr Ile Pro Tyr Ser Thr Ala Glu Gly Ile Lys 
        35                  40                  45              


Lys Phe Glu Gly Asp Gly Tyr Glu Leu Phe Lys Asp Asn Phe Pro Ala 
    50                  55                  60                  


Gly Glu Lys Phe Asp Asn Asp Asp Lys Thr Asp Gln Thr Tyr Thr Val 
65                  70                  75                  80  


Ile Phe Lys His His Arg Glu Asn Val Asp Pro Asn His Ser Ser Ala 
                85                  90                  95      


Asp Gly Thr Lys Gly Thr Lys Thr Leu Thr Glu Thr Val His Tyr Lys 
            100                 105                 110         


Tyr Ala Asp Gly Thr Lys Ala Ala Glu Asp Gln Thr Ala Gln Val Thr 
        115                 120                 125             


Phe Thr Arg Asn Gly Val Leu Asp Asp Val Thr Gly Ile Val Ala Trp 
    130                 135                 140                 


Gly Lys Trp Asn Glu Ala Ser Gln Ser Tyr Lys Ala Leu Thr Ser Pro 
145                 150                 155                 160 


Thr Ile Ala Gly Tyr Thr Pro Ser Glu Ala Val Val Lys Arg Ser Ser 
                165                 170                 175     


Asn Ser Asp Ala Glu Gln Gly 
            180             


<210>  16
<211>  192
<212>  PRT
<213>  Lactobacillus reuteri


<220>
<221>  source
<222>  (1)..(192)
<223>  MUB200

<400>  16

Thr Val Val Tyr Val Gly Asp Pro Gln Glu Ala Gln Ala Ile Phe Tyr 
1               5                   10                  15      


Asp Glu Thr Thr Gly Lys Glu Ile Ser Asn Thr Arg Glu Ile Val Asn 
            20                  25                  30          


Gly Lys Thr Asp Glu Thr Ile Gly Phe Thr Lys Asp Pro Asn Glu Val 
        35                  40                  45              


Val Lys Glu Leu Glu Lys Gln Gly Tyr Val Phe Asp Lys Asp Asn Ala 
    50                  55                  60                  


Asn Asn Asn Val Phe Ala Ala Gly Thr Thr Tyr Asp Lys Asn Ser Glu 
65                  70                  75                  80  


Val His Gln Tyr Phe Lys Tyr Tyr Phe Thr His Ala Thr Thr Ile Val 
                85                  90                  95      


Thr Pro Asp Asn Pro Lys Thr Pro Ala Asp Val Leu Pro Asp Asn Pro 
            100                 105                 110         


Gly Lys Asn Tyr Pro Ser Gly Val Ala Lys Asp Asp Leu Asn Lys Thr 
        115                 120                 125             


Val Thr Arg Thr Ile Asn Ile Thr Thr Pro Asp Gly Lys Thr Gln Thr 
    130                 135                 140                 


Ile Thr Gln Lys Ala Glu Phe Thr Arg Ser Ala Thr Val Asp Glu Val 
145                 150                 155                 160 


Thr Gly Glu Val Thr Tyr Gly Pro Trp Ser Lys Asn Val Val Leu Glu 
                165                 170                 175     


Ser Val Asp Val Pro Asn Ile Ser Gly Tyr Val Pro Ser Ala Ser Val 
            180                 185                 190         


<210>  17
<211>  10020
<212>  DNA
<213>  Lactobacillus reuteri


<220>
<221>  source
<222>  (1)..(10020)
<223>  MUB

<220>
<221>  CDS
<222>  (121)..(9927)

<400>  17
ggaagattcg ctgcaattaa ctttaaagaa gttgcaacag caaatgccaa taattgttgg       60

ttgctgaatg aatgttgatt ttttcataat gcaaaaattt taagggagag ttttagtaat      120

atg gtc ggg aaa aac aat aat tat gta agg gaa agc aaa tct aat gag        168
Met Val Gly Lys Asn Asn Asn Tyr Val Arg Glu Ser Lys Ser Asn Glu           
1               5                   10                  15                

cat ttt caa cgg ttt gcg ctg cgc aaa ctg agc gtt ggg gtt gtc tcg        216
His Phe Gln Arg Phe Ala Leu Arg Lys Leu Ser Val Gly Val Val Ser           
            20                  25                  30                    

gtt gcc gtt gcg gct ggt ttt tat tta ggc agt ggt gca aca gca cag        264
Val Ala Val Ala Ala Gly Phe Tyr Leu Gly Ser Gly Ala Thr Ala Gln           
        35                  40                  45                        

gct gca act act gaa tcg aat gca tcg gct aaa act gaa cag gtt gtg        312
Ala Ala Thr Thr Glu Ser Asn Ala Ser Ala Lys Thr Glu Gln Val Val           
    50                  55                  60                            

caa cag aac tca act tca gct gcc agt gac tca act tca aca tct aat        360
Gln Gln Asn Ser Thr Ser Ala Ala Ser Asp Ser Thr Ser Thr Ser Asn           
65                  70                  75                  80            

agc agt gca gcc gtg tcc aca agc agt gct acg ccg gta agc acc gag        408
Ser Ser Ala Ala Val Ser Thr Ser Ser Ala Thr Pro Val Ser Thr Glu           
                85                  90                  95                

tct gct tct agc atg acg gtt tct gat ttg cca gca tcg gcc agc gcg        456
Ser Ala Ser Ser Met Thr Val Ser Asp Leu Pro Ala Ser Ala Ser Ala           
            100                 105                 110                   

gct tca gac aat caa gct tcg gct gcc aat gcc agt gaa agc agt agt        504
Ala Ser Asp Asn Gln Ala Ser Ala Ala Asn Ala Ser Glu Ser Ser Ser           
        115                 120                 125                       

cag tcg gca tca agc tca gtt gcc agc gat gcc gca gct act gta agc        552
Gln Ser Ala Ser Ser Ser Val Ala Ser Asp Ala Ala Ala Thr Val Ser           
    130                 135                 140                           

aaa gac tca cag gca gct agt gaa gcc aac agt caa agc gct gct gat        600
Lys Asp Ser Gln Ala Ala Ser Glu Ala Asn Ser Gln Ser Ala Ala Asp           
145                 150                 155                 160           

gta gaa aca gta cag ttg cca acg tca gcc gct aat gcc aat gct aat        648
Val Glu Thr Val Gln Leu Pro Thr Ser Ala Ala Asn Ala Asn Ala Asn           
                165                 170                 175               

gaa agc caa gca gcc aat att ttg ggt gct caa gct gtt caa aag gct        696
Glu Ser Gln Ala Ala Asn Ile Leu Gly Ala Gln Ala Val Gln Lys Ala           
            180                 185                 190                   

gcc aat caa cag gcg cca gcc gga ttt acg gtt act gac cca aat tat        744
Ala Asn Gln Gln Ala Pro Ala Gly Phe Thr Val Thr Asp Pro Asn Tyr           
        195                 200                 205                       

ccg gca gaa atg tat aaa gat cca gat gcc agt cac tat acc tac tgg        792
Pro Ala Glu Met Tyr Lys Asp Pro Asp Ala Ser His Tyr Thr Tyr Trp           
    210                 215                 220                           

tgg gca caa agc tcg aat ggc gag tat aac ctg gtt ctt tca act gat        840
Trp Ala Gln Ser Ser Asn Gly Glu Tyr Asn Leu Val Leu Ser Thr Asp           
225                 230                 235                 240           

cgg aat ggt gat ggc aag gtt tat gtc ttc ttg ctg ggc aac aat aat        888
Arg Asn Gly Asp Gly Lys Val Tyr Val Phe Leu Leu Gly Asn Asn Asn           
                245                 250                 255               

aat gtt tta ggt aag tac acg gtt gat aaa aat aaa tca aca gaa gta        936
Asn Val Leu Gly Lys Tyr Thr Val Asp Lys Asn Lys Ser Thr Glu Val           
            260                 265                 270                   

gct act gat gac gag gga gat ttt ggc aca gtt tac aat gat ggt cag        984
Ala Thr Asp Asp Glu Gly Asp Phe Gly Thr Val Tyr Asn Asp Gly Gln           
        275                 280                 285                       

tca ggt gtc ttt gtt act tct gat ggt acc tgg aag tca aag ttc aac       1032
Ser Gly Val Phe Val Thr Ser Asp Gly Thr Trp Lys Ser Lys Phe Asn           
    290                 295                 300                           

gtt ttt gac cct aag gcg ggc gag gat gat gga gac tat ggc agt att       1080
Val Phe Asp Pro Lys Ala Gly Glu Asp Asp Gly Asp Tyr Gly Ser Ile           
305                 310                 315                 320           

agt ttc atg atc cca caa gta gaa acg cag acg acg act tac gtt act       1128
Ser Phe Met Ile Pro Gln Val Glu Thr Gln Thr Thr Thr Tyr Val Thr           
                325                 330                 335               

tat ttt gat agc aag ggt aac aag gtc gat aaa cca atc gag gtc agt       1176
Tyr Phe Asp Ser Lys Gly Asn Lys Val Asp Lys Pro Ile Glu Val Ser           
            340                 345                 350                   

gac cct gtc att caa aaa ggt ctg gat ggt caa atc tat acg aca aag       1224
Asp Pro Val Ile Gln Lys Gly Leu Asp Gly Gln Ile Tyr Thr Thr Lys           
        355                 360                 365                       

ggt ggc aaa gta atc aat ggc tat ttt gcc aaa gag cca aaa aat gcc       1272
Gly Gly Lys Val Ile Asn Gly Tyr Phe Ala Lys Glu Pro Lys Asn Ala           
    370                 375                 380                           

cat ggc ttc atg tcg cca ttt ggc aag cag ggt gca atc tac act aaa       1320
His Gly Phe Met Ser Pro Phe Gly Lys Gln Gly Ala Ile Tyr Thr Lys           
385                 390                 395                 400           

gat tgg cat gat ggg ctt aaa gcc acc ttt acc gaa act gat acc aag       1368
Asp Trp His Asp Gly Leu Lys Ala Thr Phe Thr Glu Thr Asp Thr Lys           
                405                 410                 415               

acc ggc ttg atg cat gtt gtt gtg aaa cat tat tat cat agt tgg ggt       1416
Thr Gly Leu Met His Val Val Val Lys His Tyr Tyr His Ser Trp Gly           
            420                 425                 430                   

tgg gga act tgg cgg aca gta aaa gag ttt gat ctt gcc cca ggt caa       1464
Trp Gly Thr Trp Arg Thr Val Lys Glu Phe Asp Leu Ala Pro Gly Gln           
        435                 440                 445                       

tca gag aaa gtt gac tat gat gtc tat aaa tca gtt act att cac agc       1512
Ser Glu Lys Val Asp Tyr Asp Val Tyr Lys Ser Val Thr Ile His Ser           
    450                 455                 460                           

atc tac att cca cag acg atc aac att caa tac acc tat gaa aag ctg       1560
Ile Tyr Ile Pro Gln Thr Ile Asn Ile Gln Tyr Thr Tyr Glu Lys Leu           
465                 470                 475                 480           

ggc aat ctg gtc atc agt tct gac agc aag tcc ttc cca gct gaa gat       1608
Gly Asn Leu Val Ile Ser Ser Asp Ser Lys Ser Phe Pro Ala Glu Asp           
                485                 490                 495               

aag act caa tat cca aat gat aag tct gac tca acc aag gcc ggt aat       1656
Lys Thr Gln Tyr Pro Asn Asp Lys Ser Asp Ser Thr Lys Ala Gly Asn           
            500                 505                 510                   

gtt aca att cca aag gta gcc ggc ttt acg cca acg atc aat gac aag       1704
Val Thr Ile Pro Lys Val Ala Gly Phe Thr Pro Thr Ile Asn Asp Lys           
        515                 520                 525                       

acg gtg aca aac tac acg ttt aac cct tct gat tac gtc agc gat ctg       1752
Thr Val Thr Asn Tyr Thr Phe Asn Pro Ser Asp Tyr Val Ser Asp Leu           
    530                 535                 540                           

agt aag gac att aat gtt gtt tat gta gct gac acg caa gaa gct gcc       1800
Ser Lys Asp Ile Asn Val Val Tyr Val Ala Asp Thr Gln Glu Ala Ala           
545                 550                 555                 560           

atc agc ttc tat gac gag aca gac cac aag cca ctg aat gac caa acg       1848
Ile Ser Phe Tyr Asp Glu Thr Asp His Lys Pro Leu Asn Asp Gln Thr           
                565                 570                 575               

att cag ctg act ggc aag act ggt gaa aag atc agc cat acc gaa gct       1896
Ile Gln Leu Thr Gly Lys Thr Gly Glu Lys Ile Ser His Thr Glu Ala           
            580                 585                 590                   

aat caa aca ctg gct aag ctg gga aag caa ggc tat gtt gtc gac cag       1944
Asn Gln Thr Leu Ala Lys Leu Gly Lys Gln Gly Tyr Val Val Asp Gln           
        595                 600                 605                       

aat act ttt gct gat gat gca acg tat gac aac gat acg caa gca cca       1992
Asn Thr Phe Ala Asp Asp Ala Thr Tyr Asp Asn Asp Thr Gln Ala Pro           
    610                 615                 620                           

caa gag ttt acg atc tac ctc aag cat gat acg acc cat act gac gca       2040
Gln Glu Phe Thr Ile Tyr Leu Lys His Asp Thr Thr His Thr Asp Ala           
625                 630                 635                 640           

act agc tca aag gca gat caa aag acc gtc agc gaa acg att cac tac       2088
Thr Ser Ser Lys Ala Asp Gln Lys Thr Val Ser Glu Thr Ile His Tyr           
                645                 650                 655               

gtc tac aaa gat ggg gtc aac gct aat aag ccg gta gct gat gac gct       2136
Val Tyr Lys Asp Gly Val Asn Ala Asn Lys Pro Val Ala Asp Asp Ala           
            660                 665                 670                   

aat aca acg gtt acc ttc aaa cgc ggc tac acg act gac aaa gtt acg       2184
Asn Thr Thr Val Thr Phe Lys Arg Gly Tyr Thr Thr Asp Lys Val Thr           
        675                 680                 685                       

gga aag att gtt tcc tat gat cct tgg acg gtt gat ggc aag caa gcc       2232
Gly Lys Ile Val Ser Tyr Asp Pro Trp Thr Val Asp Gly Lys Gln Ala           
    690                 695                 700                           

gac agc aag acg ttt gat gcc gtc aag agt cca gtc att gct ggt tac       2280
Asp Ser Lys Thr Phe Asp Ala Val Lys Ser Pro Val Ile Ala Gly Tyr           
705                 710                 715                 720           

acg gcc gat caa gca gaa gtt gcc gct caa acg gta acg cca gat tcc       2328
Thr Ala Asp Gln Ala Glu Val Ala Ala Gln Thr Val Thr Pro Asp Ser           
                725                 730                 735               

caa aat att aac aag aca gtt tac tat acc gct gac acg caa gaa gct       2376
Gln Asn Ile Asn Lys Thr Val Tyr Tyr Thr Ala Asp Thr Gln Glu Ala           
            740                 745                 750                   

gcc atc aac ttc tat gac gag aca ggc cac aag ctg tta gat aac caa       2424
Ala Ile Asn Phe Tyr Asp Glu Thr Gly His Lys Leu Leu Asp Asn Gln           
        755                 760                 765                       

acg att cat ttg act ggc aag acc ggt gaa aag gta gac cgg acg caa       2472
Thr Ile His Leu Thr Gly Lys Thr Gly Glu Lys Val Asp Arg Thr Gln           
    770                 775                 780                           

gcg gac cag acg ttg gct gat ctg gta aag caa ggc tat gtt ttg gat       2520
Ala Asp Gln Thr Leu Ala Asp Leu Val Lys Gln Gly Tyr Val Leu Asp           
785                 790                 795                 800           

aaa gaa aac acg gcc aag gca ttc cca gct gac gcg gta tat gac aac       2568
Lys Glu Asn Thr Ala Lys Ala Phe Pro Ala Asp Ala Val Tyr Asp Asn           
                805                 810                 815               

aat gac caa acg cca caa gag ttt acg atc tac ctc aag cat ggt acg       2616
Asn Asp Gln Thr Pro Gln Glu Phe Thr Ile Tyr Leu Lys His Gly Thr           
            820                 825                 830                   

acc cat act gac gca acc agc tca aag gca gat caa aag acc gtc agc       2664
Thr His Thr Asp Ala Thr Ser Ser Lys Ala Asp Gln Lys Thr Val Ser           
        835                 840                 845                       

gaa acg att cac tac gtc tac aaa gat ggg gtc aac gct aat aag ccg       2712
Glu Thr Ile His Tyr Val Tyr Lys Asp Gly Val Asn Ala Asn Lys Pro           
    850                 855                 860                           

gta gct gat gac gct aat aca acg gtt acc ttc aaa cgc ggc tac acg       2760
Val Ala Asp Asp Ala Asn Thr Thr Val Thr Phe Lys Arg Gly Tyr Thr           
865                 870                 875                 880           

act gac aaa gtt acg gga aag att gtt tcc tat gat cct tgg acg gtt       2808
Thr Asp Lys Val Thr Gly Lys Ile Val Ser Tyr Asp Pro Trp Thr Val           
                885                 890                 895               

gat ggc aag caa gcc gac agc aag acg ttt gat gcc gtc aag agt cca       2856
Asp Gly Lys Gln Ala Asp Ser Lys Thr Phe Asp Ala Val Lys Ser Pro           
            900                 905                 910                   

gtc att gct ggt tac acg gcc gat caa gca gaa gtt gcc gct caa acg       2904
Val Ile Ala Gly Tyr Thr Ala Asp Gln Ala Glu Val Ala Ala Gln Thr           
        915                 920                 925                       

gta acg cca gat tcc caa aat att aac aag aca gtt tac tat acc gct       2952
Val Thr Pro Asp Ser Gln Asn Ile Asn Lys Thr Val Tyr Tyr Thr Ala           
    930                 935                 940                           

gac acg caa gaa gct gcc atc aac ttc tat gac gag aca ggc cac aag       3000
Asp Thr Gln Glu Ala Ala Ile Asn Phe Tyr Asp Glu Thr Gly His Lys           
945                 950                 955                 960           

ctg tta gat aac caa acg att cat ctg act ggc aag act ggt gaa aag       3048
Leu Leu Asp Asn Gln Thr Ile His Leu Thr Gly Lys Thr Gly Glu Lys           
                965                 970                 975               

gtt gat cgg acg caa gcg gac cag acg ctg gct gaa ctg gaa aaa caa       3096
Val Asp Arg Thr Gln Ala Asp Gln Thr Leu Ala Glu Leu Glu Lys Gln           
            980                 985                 990                   

ggc tac gtt ctg gat gag aat aac  act aaa ctg gga ttc  cca tcc aat     3144
Gly Tyr Val Leu Asp Glu Asn Asn  Thr Lys Leu Gly Phe  Pro Ser Asn         
        995                 1000                 1005                     

gca gcg  tat gac gat gat gac  gtt aag cca caa gag  ttt acg atc        3189
Ala Ala  Tyr Asp Asp Asp Asp  Val Lys Pro Gln Glu  Phe Thr Ile            
    1010                 1015                 1020                        

tat ctg  aag cat ggc atg acg  cat acc gat gca acc  gac aag aat        3234
Tyr Leu  Lys His Gly Met Thr  His Thr Asp Ala Thr  Asp Lys Asn            
    1025                 1030                 1035                        

gct gaa  caa aag att gtt acg  gaa acg att cac tac  gtt tac gaa        3279
Ala Glu  Gln Lys Ile Val Thr  Glu Thr Ile His Tyr  Val Tyr Glu            
    1040                 1045                 1050                        

aac aac  cag act gct aag aca  gac tac acg tca gcg  gtt gac ttt        3324
Asn Asn  Gln Thr Ala Lys Thr  Asp Tyr Thr Ser Ala  Val Asp Phe            
    1055                 1060                 1065                        

aag cgc  ggc tac acg act gac  aac gtt acg cat aag  att att tcc        3369
Lys Arg  Gly Tyr Thr Thr Asp  Asn Val Thr His Lys  Ile Ile Ser            
    1070                 1075                 1080                        

tac gat  cca tgg atg gta tcc  agc aag aag ttt ggt  ttc gta aag        3414
Tyr Asp  Pro Trp Met Val Ser  Ser Lys Lys Phe Gly  Phe Val Lys            
    1085                 1090                 1095                        

agt cca  gcc att gaa ggc tac  acg cca aac cat tcg  cag att gat        3459
Ser Pro  Ala Ile Glu Gly Tyr  Thr Pro Asn His Ser  Gln Ile Asp            
    1100                 1105                 1110                        

gaa atc  act gtt acg cca gat  tca aaa gac gtc gtc  aag acg gtg        3504
Glu Ile  Thr Val Thr Pro Asp  Ser Lys Asp Val Val  Lys Thr Val            
    1115                 1120                 1125                        

gtt tat  gtt ggg aat gcc caa  gaa gcc caa gcc atc  ttc tat gat        3549
Val Tyr  Val Gly Asn Ala Gln  Glu Ala Gln Ala Ile  Phe Tyr Asp            
    1130                 1135                 1140                        

gaa acg  acg ggc aaa gaa atc  agt ggg aca cgt gaa  att gca act        3594
Glu Thr  Thr Gly Lys Glu Ile  Ser Gly Thr Arg Glu  Ile Ala Thr            
    1145                 1150                 1155                        

ggc aag  act gat gaa acg atc  agc ttt acc aag gat  cca aat gaa        3639
Gly Lys  Thr Asp Glu Thr Ile  Ser Phe Thr Lys Asp  Pro Asn Glu            
    1160                 1165                 1170                        

gtc gtt  aag gaa ctc gaa aag  cag ggt tac gtt ttt  gac aag gat        3684
Val Val  Lys Glu Leu Glu Lys  Gln Gly Tyr Val Phe  Asp Lys Asp            
    1175                 1180                 1185                        

aac gct  aag aat aat gtc ttt  gtc gct gga acg gcc  tac gac aag        3729
Asn Ala  Lys Asn Asn Val Phe  Val Ala Gly Thr Ala  Tyr Asp Lys            
    1190                 1195                 1200                        

aat tcc  gaa gtt cac caa tac  ttc aag tac tac ctg  aag cac gga        3774
Asn Ser  Glu Val His Gln Tyr  Phe Lys Tyr Tyr Leu  Lys His Gly            
    1205                 1210                 1215                        

cat gcg  acg gta acg cca gac  caa gat cca caa aaa  ggt caa aag        3819
His Ala  Thr Val Thr Pro Asp  Gln Asp Pro Gln Lys  Gly Gln Lys            
    1220                 1225                 1230                        

acg gtt  aca cag aca att aag  tac gaa tac gct gat  ggc acg gca        3864
Thr Val  Thr Gln Thr Ile Lys  Tyr Glu Tyr Ala Asp  Gly Thr Ala            
    1235                 1240                 1245                        

act ggt  ttg gct gat aat gtg  caa acc ttg acg ttc  aag cgt aca        3909
Thr Gly  Leu Ala Asp Asn Val  Gln Thr Leu Thr Phe  Lys Arg Thr            
    1250                 1255                 1260                        

ggt gac  aag gat ctc gtt act  cat gaa gta acc tgg  cca gac tgg        3954
Gly Asp  Lys Asp Leu Val Thr  His Glu Val Thr Trp  Pro Asp Trp            
    1265                 1270                 1275                        

tca acg  gtt gcc ggt caa caa  acc agt gtt gta acc  agt cca gct        3999
Ser Thr  Val Ala Gly Gln Gln  Thr Ser Val Val Thr  Ser Pro Ala            
    1280                 1285                 1290                        

ctc aag  ggc tac act gct gat  acc aac gaa att cca  gcc att acc        4044
Leu Lys  Gly Tyr Thr Ala Asp  Thr Asn Glu Ile Pro  Ala Ile Thr            
    1295                 1300                 1305                        

tac cat  gct ggt gac agt gat  gtt act tat gtt gtt  aag tac aat        4089
Tyr His  Ala Gly Asp Ser Asp  Val Thr Tyr Val Val  Lys Tyr Asn            
    1310                 1315                 1320                        

gcc gat  gtt caa cat gct gtt  atc aat tac att gat  ggc gaa agt        4134
Ala Asp  Val Gln His Ala Val  Ile Asn Tyr Ile Asp  Gly Glu Ser            
    1325                 1330                 1335                        

gat gag  ata ctg cac act gat  aag gtt aat ggc cac  tct gac gaa        4179
Asp Glu  Ile Leu His Thr Asp  Lys Val Asn Gly His  Ser Asp Glu            
    1340                 1345                 1350                        

aag atc  aac tac agc act gct  gat atg atc aaa cag  ttg gaa gcc        4224
Lys Ile  Asn Tyr Ser Thr Ala  Asp Met Ile Lys Gln  Leu Glu Ala            
    1355                 1360                 1365                        

aag ggt  tat gaa ctg ttc aag  gac aac ttc cca gct  ggt gag aag        4269
Lys Gly  Tyr Glu Leu Phe Lys  Asp Asn Phe Pro Ala  Gly Glu Lys            
    1370                 1375                 1380                        

ttc gat  aac gat gac acc aac  gat caa ttc tac acg  gta atc ttc        4314
Phe Asp  Asn Asp Asp Thr Asn  Asp Gln Phe Tyr Thr  Val Ile Phe            
    1385                 1390                 1395                        

aag cac  cat cgt gaa aac gtt  gat cca aac cac tcc  tcg gct gat        4359
Lys His  His Arg Glu Asn Val  Asp Pro Asn His Ser  Ser Ala Asp            
    1400                 1405                 1410                        

ggc acg  aag ggt acg aag acg  ctg acg gaa acg gtt  cac tac aag        4404
Gly Thr  Lys Gly Thr Lys Thr  Leu Thr Glu Thr Val  His Tyr Lys            
    1415                 1420                 1425                        

tac gct  aat ggc acc aag gcg  gct gaa gat cag acg  gct cag gta        4449
Tyr Ala  Asn Gly Thr Lys Ala  Ala Glu Asp Gln Thr  Ala Gln Val            
    1430                 1435                 1440                        

acg ttt  acg cgg aac ggt gtc  ctg gat gac gtt acg  ggt atc gtg        4494
Thr Phe  Thr Arg Asn Gly Val  Leu Asp Asp Val Thr  Gly Ile Val            
    1445                 1450                 1455                        

gcc tgg  ggc aag tgg aac gaa  gcc agc cag agc tac  aag gct ttg        4539
Ala Trp  Gly Lys Trp Asn Glu  Ala Ser Gln Ser Tyr  Lys Ala Leu            
    1460                 1465                 1470                        

act tca  cca acg att gcc ggc  tac gcg cca agc gaa  gcg gtg gta        4584
Thr Ser  Pro Thr Ile Ala Gly  Tyr Ala Pro Ser Glu  Ala Val Val            
    1475                 1480                 1485                        

aag cgc  agt tcc aac agc gat  gcc gaa caa ggc cca  acg ctt acg        4629
Lys Arg  Ser Ser Asn Ser Asp  Ala Glu Gln Gly Pro  Thr Leu Thr            
    1490                 1495                 1500                        

gtc att  tac acg gct gat gcc  caa aag gtt cac gtt  caa tac att        4674
Val Ile  Tyr Thr Ala Asp Ala  Gln Lys Val His Val  Gln Tyr Ile            
    1505                 1510                 1515                        

gat ggt  gaa act gac cag atg  ctg cgt cag gat gat  ttg gac ggc        4719
Asp Gly  Glu Thr Asp Gln Met  Leu Arg Gln Asp Asp  Leu Asp Gly            
    1520                 1525                 1530                        

tac acg  gat gaa acg att cct  tac agc acg gct gaa  ggc atc aag        4764
Tyr Thr  Asp Glu Thr Ile Pro  Tyr Ser Thr Ala Glu  Gly Ile Lys            
    1535                 1540                 1545                        

aag ttt  gaa ggc gac ggt tat  gaa ctg ttc aag gac  aac ttc cca        4809
Lys Phe  Glu Gly Asp Gly Tyr  Glu Leu Phe Lys Asp  Asn Phe Pro            
    1550                 1555                 1560                        

gct ggt  gag aag ttc gat aac  gat gac aag aat gac  caa acc tac        4854
Ala Gly  Glu Lys Phe Asp Asn  Asp Asp Lys Asn Asp  Gln Thr Tyr            
    1565                 1570                 1575                        

acg gta  atc ttc aag cac cat  cgt gaa aac gtt gat  cca aac cac        4899
Thr Val  Ile Phe Lys His His  Arg Glu Asn Val Asp  Pro Asn His            
    1580                 1585                 1590                        

tcc tcg  gct gat ggc acg aag  ggt acg aag acg ctg  acg gaa acg        4944
Ser Ser  Ala Asp Gly Thr Lys  Gly Thr Lys Thr Leu  Thr Glu Thr            
    1595                 1600                 1605                        

gtt cac  tac aag tac gca gat  ggt acc aag gcc gct  gaa gat cag        4989
Val His  Tyr Lys Tyr Ala Asp  Gly Thr Lys Ala Ala  Glu Asp Gln            
    1610                 1615                 1620                        

acg gct  cag gta acg ttt acg  cgg aac ggt gtc ctg  gat gac gtt        5034
Thr Ala  Gln Val Thr Phe Thr  Arg Asn Gly Val Leu  Asp Asp Val            
    1625                 1630                 1635                        

acg ggt  atc gtg gcc tgg ggc  aag tgg aac gaa gcc  agc cag agc        5079
Thr Gly  Ile Val Ala Trp Gly  Lys Trp Asn Glu Ala  Ser Gln Ser            
    1640                 1645                 1650                        

tac aag  gct ttg act tca cca  acg att gcc ggc tac  acg cca agc        5124
Tyr Lys  Ala Leu Thr Ser Pro  Thr Ile Ala Gly Tyr  Thr Pro Ser            
    1655                 1660                 1665                        

gaa gcg  gtg gta aag cgc agt  tcc aac agc gat gcc  gaa caa ggc        5169
Glu Ala  Val Val Lys Arg Ser  Ser Asn Ser Asp Ala  Glu Gln Gly            
    1670                 1675                 1680                        

cca acg  ctt acg gtc atc tac  acg gct gat gcc caa  aag gtt cac        5214
Pro Thr  Leu Thr Val Ile Tyr  Thr Ala Asp Ala Gln  Lys Val His            
    1685                 1690                 1695                        

gtt caa  tac att gat ggt gaa  act gac cag atg ctg  cgt cag gat        5259
Val Gln  Tyr Ile Asp Gly Glu  Thr Asp Gln Met Leu  Arg Gln Asp            
    1700                 1705                 1710                        

gat ttg  gac ggc tac acg gat  gaa acg att cct tac  agc acg gct        5304
Asp Leu  Asp Gly Tyr Thr Asp  Glu Thr Ile Pro Tyr  Ser Thr Ala            
    1715                 1720                 1725                        

gaa ggc  atc aag aag ttt gaa  ggc gac ggt tat gaa  ctg ttc aag        5349
Glu Gly  Ile Lys Lys Phe Glu  Gly Asp Gly Tyr Glu  Leu Phe Lys            
    1730                 1735                 1740                        

gac aac  ttc cca gct ggt gag  aag ttc gat aac gat  gac acc aac        5394
Asp Asn  Phe Pro Ala Gly Glu  Lys Phe Asp Asn Asp  Asp Thr Asn            
    1745                 1750                 1755                        

gat caa  ttc tac acg gta atc  ttc aag cac cat cgt  gaa aac gtt        5439
Asp Gln  Phe Tyr Thr Val Ile  Phe Lys His His Arg  Glu Asn Val            
    1760                 1765                 1770                        

gat cca  aac cac tcc tcg gct  gat ggc acg aag ggt  acg aag acg        5484
Asp Pro  Asn His Ser Ser Ala  Asp Gly Thr Lys Gly  Thr Lys Thr            
    1775                 1780                 1785                        

ctg acg  gaa acg gtt cac tac  aag tac gct aat ggc  acc aag gcg        5529
Leu Thr  Glu Thr Val His Tyr  Lys Tyr Ala Asn Gly  Thr Lys Ala            
    1790                 1795                 1800                        

gct gaa  gat cag acg gct cag  gta acg ttt acg cgg  aac ggt gtc        5574
Ala Glu  Asp Gln Thr Ala Gln  Val Thr Phe Thr Arg  Asn Gly Val            
    1805                 1810                 1815                        

ctg gat  gac gtt acg ggt atc  gtg gcc tgg ggc aag  tgg aac gaa        5619
Leu Asp  Asp Val Thr Gly Ile  Val Ala Trp Gly Lys  Trp Asn Glu            
    1820                 1825                 1830                        

gcc agc  cag agc tac aag gct  ttg act tca cca acg  att gcc ggc        5664
Ala Ser  Gln Ser Tyr Lys Ala  Leu Thr Ser Pro Thr  Ile Ala Gly            
    1835                 1840                 1845                        

tac gcg  cca agc gaa gcg gtg  gta aag cgc agt tcc  aac agc gat        5709
Tyr Ala  Pro Ser Glu Ala Val  Val Lys Arg Ser Ser  Asn Ser Asp            
    1850                 1855                 1860                        

gcc gaa  caa ggc cca acg ctt  acg gtc att tac acg  gct gat gcc        5754
Ala Glu  Gln Gly Pro Thr Leu  Thr Val Ile Tyr Thr  Ala Asp Ala            
    1865                 1870                 1875                        

caa aag  gtt cac gtt caa tac  att gat ggt gaa act  gac cag atg        5799
Gln Lys  Val His Val Gln Tyr  Ile Asp Gly Glu Thr  Asp Gln Met            
    1880                 1885                 1890                        

ctg cgt  cag gat gat ttg gac  ggc tac acg gat gaa  acg att cct        5844
Leu Arg  Gln Asp Asp Leu Asp  Gly Tyr Thr Asp Glu  Thr Ile Pro            
    1895                 1900                 1905                        

tac agc  acg gct gaa ggc atc  aag aag ttt gaa ggc  gac ggt tat        5889
Tyr Ser  Thr Ala Glu Gly Ile  Lys Lys Phe Glu Gly  Asp Gly Tyr            
    1910                 1915                 1920                        

gaa ctg  ttc aag gac aac ttc  cca gct ggt gag aag  ttc gat aac        5934
Glu Leu  Phe Lys Asp Asn Phe  Pro Ala Gly Glu Lys  Phe Asp Asn            
    1925                 1930                 1935                        

gat gac  aag aat gac caa acc  tac acg gta atc ttc  aag cac cat        5979
Asp Asp  Lys Asn Asp Gln Thr  Tyr Thr Val Ile Phe  Lys His His            
    1940                 1945                 1950                        

cgt gaa  aac gtt gat cca aac  cac tcc tcg gct gat  ggc acg aag        6024
Arg Glu  Asn Val Asp Pro Asn  His Ser Ser Ala Asp  Gly Thr Lys            
    1955                 1960                 1965                        

ggt acg  aag acg ctg acg gaa  acg gtt cac tac aag  tac gca gat        6069
Gly Thr  Lys Thr Leu Thr Glu  Thr Val His Tyr Lys  Tyr Ala Asp            
    1970                 1975                 1980                        

ggt acc  aag gcc gct gaa gat  cag acg gct cag gta  acg ttt acg        6114
Gly Thr  Lys Ala Ala Glu Asp  Gln Thr Ala Gln Val  Thr Phe Thr            
    1985                 1990                 1995                        

cgg aac  ggt gtc ctg gat gac  gtt acg ggt atc gtg  gcc tgg ggc        6159
Arg Asn  Gly Val Leu Asp Asp  Val Thr Gly Ile Val  Ala Trp Gly            
    2000                 2005                 2010                        

aag tgg  aac gaa gcc agc cag  agc tac aag gct ttg  act tca cca        6204
Lys Trp  Asn Glu Ala Ser Gln  Ser Tyr Lys Ala Leu  Thr Ser Pro            
    2015                 2020                 2025                        

acg att  gcc ggc tac acg cca  agc gaa gcg gtg gta  aag cgc agt        6249
Thr Ile  Ala Gly Tyr Thr Pro  Ser Glu Ala Val Val  Lys Arg Ser            
    2030                 2035                 2040                        

tcc aac  agc gat gcc gaa caa  ggc cca acg ctt acg  gtc atc tac        6294
Ser Asn  Ser Asp Ala Glu Gln  Gly Pro Thr Leu Thr  Val Ile Tyr            
    2045                 2050                 2055                        

acg gct  gat gcc caa aag gtt  cac gtt caa tac att  gat ggt gaa        6339
Thr Ala  Asp Ala Gln Lys Val  His Val Gln Tyr Ile  Asp Gly Glu            
    2060                 2065                 2070                        

act gac  cag atg ctg cgt cag  gat gat ttg gac ggc  tac acg gat        6384
Thr Asp  Gln Met Leu Arg Gln  Asp Asp Leu Asp Gly  Tyr Thr Asp            
    2075                 2080                 2085                        

gaa acg  att cct tac agc acg  gct gaa ggc atc aag  aag ttt gaa        6429
Glu Thr  Ile Pro Tyr Ser Thr  Ala Glu Gly Ile Lys  Lys Phe Glu            
    2090                 2095                 2100                        

ggc gac  ggt tat gaa ctg ttc  aag gac aac ttc cca  gct ggt gag        6474
Gly Asp  Gly Tyr Glu Leu Phe  Lys Asp Asn Phe Pro  Ala Gly Glu            
    2105                 2110                 2115                        

aag ttc  gat aac gat gac acc  aac gat caa ttc tac  acg gta atc        6519
Lys Phe  Asp Asn Asp Asp Thr  Asn Asp Gln Phe Tyr  Thr Val Ile            
    2120                 2125                 2130                        

ttc aag  cac cat cgt gaa aac  gtt gat cca aac cac  tcc tcg gct        6564
Phe Lys  His His Arg Glu Asn  Val Asp Pro Asn His  Ser Ser Ala            
    2135                 2140                 2145                        

gat ggc  acg aag ggt acg aag  acg ctg acg gaa acg  gtt cac tac        6609
Asp Gly  Thr Lys Gly Thr Lys  Thr Leu Thr Glu Thr  Val His Tyr            
    2150                 2155                 2160                        

aag tac  gct aat ggc acc aag  gcg gct gaa gat cag  acg gct cag        6654
Lys Tyr  Ala Asn Gly Thr Lys  Ala Ala Glu Asp Gln  Thr Ala Gln            
    2165                 2170                 2175                        

gta acg  ttt acg cgg aac ggt  gtc ctg gat gac gtt  acg ggt atc        6699
Val Thr  Phe Thr Arg Asn Gly  Val Leu Asp Asp Val  Thr Gly Ile            
    2180                 2185                 2190                        

gtg gcc  tgg ggc aag tgg aac  gaa gcc agc cag agc  tac aag gct        6744
Val Ala  Trp Gly Lys Trp Asn  Glu Ala Ser Gln Ser  Tyr Lys Ala            
    2195                 2200                 2205                        

ttg act  tca cca acg att gcc  ggc tac gcg cca agc  gaa gcg gtg        6789
Leu Thr  Ser Pro Thr Ile Ala  Gly Tyr Ala Pro Ser  Glu Ala Val            
    2210                 2215                 2220                        

gta aag  cgc agt tcc aac agc  gat gcc gaa caa ggc  cca acg ctt        6834
Val Lys  Arg Ser Ser Asn Ser  Asp Ala Glu Gln Gly  Pro Thr Leu            
    2225                 2230                 2235                        

acg gtc  atc tac acg gct gat  gcc caa aag gtt cac  gtt caa tac        6879
Thr Val  Ile Tyr Thr Ala Asp  Ala Gln Lys Val His  Val Gln Tyr            
    2240                 2245                 2250                        

att gat  ggt gaa act gac cag  atg ctg cgt cag gat  gat ttg gac        6924
Ile Asp  Gly Glu Thr Asp Gln  Met Leu Arg Gln Asp  Asp Leu Asp            
    2255                 2260                 2265                        

ggc tac  acg gat gaa acg att  cct tac agc acg gct  gaa ggc atc        6969
Gly Tyr  Thr Asp Glu Thr Ile  Pro Tyr Ser Thr Ala  Glu Gly Ile            
    2270                 2275                 2280                        

aag aag  ttt gaa ggc gac ggt  tat gaa ctg ttc aag  gac aac ttc        7014
Lys Lys  Phe Glu Gly Asp Gly  Tyr Glu Leu Phe Lys  Asp Asn Phe            
    2285                 2290                 2295                        

cca gct  ggt gag aag ttc gat  aac gat gac aag aat  gac caa acc        7059
Pro Ala  Gly Glu Lys Phe Asp  Asn Asp Asp Lys Asn  Asp Gln Thr            
    2300                 2305                 2310                        

tac acg  gta atc ttc aag cac  cat cgt gaa aac gtt  gat cca aac        7104
Tyr Thr  Val Ile Phe Lys His  His Arg Glu Asn Val  Asp Pro Asn            
    2315                 2320                 2325                        

cac tcc  tcg gct gat ggc acg  aag ggt acg aag acg  ctg acg gaa        7149
His Ser  Ser Ala Asp Gly Thr  Lys Gly Thr Lys Thr  Leu Thr Glu            
    2330                 2335                 2340                        

acg gtt  cac tac aag tac gca  gat ggt acc aag gcc  gct gaa gat        7194
Thr Val  His Tyr Lys Tyr Ala  Asp Gly Thr Lys Ala  Ala Glu Asp            
    2345                 2350                 2355                        

cag acg  gct cag gta acg ttt  acg cgg aac ggt gtc  ctg gat gac        7239
Gln Thr  Ala Gln Val Thr Phe  Thr Arg Asn Gly Val  Leu Asp Asp            
    2360                 2365                 2370                        

gtt acg  ggt atc gtg gcc tgg  ggc aag tgg aac gaa  gcc agc cag        7284
Val Thr  Gly Ile Val Ala Trp  Gly Lys Trp Asn Glu  Ala Ser Gln            
    2375                 2380                 2385                        

agc tac  aag gct ttg act tca  cca acg att gcc ggc  tac acg cca        7329
Ser Tyr  Lys Ala Leu Thr Ser  Pro Thr Ile Ala Gly  Tyr Thr Pro            
    2390                 2395                 2400                        

agc gaa  gcg gtg gta aag cgc  agt tcc aac agc gat  gcc gaa caa        7374
Ser Glu  Ala Val Val Lys Arg  Ser Ser Asn Ser Asp  Ala Glu Gln            
    2405                 2410                 2415                        

ggc cca  acg ctt acg gtc atc  tac acg gct gat gcc  caa aag gtt        7419
Gly Pro  Thr Leu Thr Val Ile  Tyr Thr Ala Asp Ala  Gln Lys Val            
    2420                 2425                 2430                        

cac gtt  caa tac att gat ggt  gaa act gac cag atg  ctg cgt cag        7464
His Val  Gln Tyr Ile Asp Gly  Glu Thr Asp Gln Met  Leu Arg Gln            
    2435                 2440                 2445                        

gat gat  ttg gac ggc tac acg  gat gaa acg att cct  tac agc acg        7509
Asp Asp  Leu Asp Gly Tyr Thr  Asp Glu Thr Ile Pro  Tyr Ser Thr            
    2450                 2455                 2460                        

gct gaa  ggc atc aag aag ttt  gaa ggc gac ggt tat  gaa ctg ttc        7554
Ala Glu  Gly Ile Lys Lys Phe  Glu Gly Asp Gly Tyr  Glu Leu Phe            
    2465                 2470                 2475                        

aag gac  aac ttc cca gct ggt  gag aag ttc gac aac  gat gac aag        7599
Lys Asp  Asn Phe Pro Ala Gly  Glu Lys Phe Asp Asn  Asp Asp Lys            
    2480                 2485                 2490                        

act gac  caa acc tac acg gta  atc ttc aag cac cat  cgt gaa aac        7644
Thr Asp  Gln Thr Tyr Thr Val  Ile Phe Lys His His  Arg Glu Asn            
    2495                 2500                 2505                        

gtt gat  cca aac cac tcc tcg  gct gac ggc acg aaa  ggt acg aag        7689
Val Asp  Pro Asn His Ser Ser  Ala Asp Gly Thr Lys  Gly Thr Lys            
    2510                 2515                 2520                        

acg ctg  acg gaa acg gtt cac  tac aag tac gca gat  ggt acc aag        7734
Thr Leu  Thr Glu Thr Val His  Tyr Lys Tyr Ala Asp  Gly Thr Lys            
    2525                 2530                 2535                        

gcc gct  gaa gat cag acg gct  cag gta acg ttt acg  cgg aac ggt        7779
Ala Ala  Glu Asp Gln Thr Ala  Gln Val Thr Phe Thr  Arg Asn Gly            
    2540                 2545                 2550                        

gtc ctg  gat gac gtt acg ggt  atc gtg gcc tgg ggc  aag tgg aac        7824
Val Leu  Asp Asp Val Thr Gly  Ile Val Ala Trp Gly  Lys Trp Asn            
    2555                 2560                 2565                        

gaa gcc  agc caa agc tac aag  gct ctg act tca cca  acg att gcc        7869
Glu Ala  Ser Gln Ser Tyr Lys  Ala Leu Thr Ser Pro  Thr Ile Ala            
    2570                 2575                 2580                        

ggc tac  acg cca agt gaa gcg  gta gta aag cgc agt  tcc aac agc        7914
Gly Tyr  Thr Pro Ser Glu Ala  Val Val Lys Arg Ser  Ser Asn Ser            
    2585                 2590                 2595                        

gat gcc  gaa caa ggc cca acg  ctt acg gtc atc tac  acg gct gat        7959
Asp Ala  Glu Gln Gly Pro Thr  Leu Thr Val Ile Tyr  Thr Ala Asp            
    2600                 2605                 2610                        

gcc caa  aca gcc tac gtc aag  tac gtt gat gac acg  act ggc gag        8004
Ala Gln  Thr Ala Tyr Val Lys  Tyr Val Asp Asp Thr  Thr Gly Glu            
    2615                 2620                 2625                        

acg ctg  cgt caa gac gat ctg  cac ggc tac acg gat  gaa acg att        8049
Thr Leu  Arg Gln Asp Asp Leu  His Gly Tyr Thr Asp  Glu Thr Ile            
    2630                 2635                 2640                        

cct tac  agc acg gct gaa ggc  atc aag aag ttt gaa  ggc gac ggt        8094
Pro Tyr  Ser Thr Ala Glu Gly  Ile Lys Lys Phe Glu  Gly Asp Gly            
    2645                 2650                 2655                        

tat gaa  ctg ttc aag gac aac  ttc cca gct ggt gag  aag ttc gac        8139
Tyr Glu  Leu Phe Lys Asp Asn  Phe Pro Ala Gly Glu  Lys Phe Asp            
    2660                 2665                 2670                        

aac gat  gac aag act gac caa  acc tac acg gta atc  ttc aag cac        8184
Asn Asp  Asp Lys Thr Asp Gln  Thr Tyr Thr Val Ile  Phe Lys His            
    2675                 2680                 2685                        

cat cgt  gaa aac gtt gat cca  aac cac tcc tcg gct  gac ggc acg        8229
His Arg  Glu Asn Val Asp Pro  Asn His Ser Ser Ala  Asp Gly Thr            
    2690                 2695                 2700                        

aaa ggt  acg aag acg ctg acg  gaa acg gtt cac tac  aag tac gca        8274
Lys Gly  Thr Lys Thr Leu Thr  Glu Thr Val His Tyr  Lys Tyr Ala            
    2705                 2710                 2715                        

gat ggt  acc aag gcc gct gaa  gat cag acg gct cag  gta acg ttt        8319
Asp Gly  Thr Lys Ala Ala Glu  Asp Gln Thr Ala Gln  Val Thr Phe            
    2720                 2725                 2730                        

acg cgg  aac ggt gtc ctg gat  gac gtt acg ggt atc  gtg gcc tgg        8364
Thr Arg  Asn Gly Val Leu Asp  Asp Val Thr Gly Ile  Val Ala Trp            
    2735                 2740                 2745                        

ggc aag  tgg aac gaa gcc agc  caa agc tac aag gct  ctg act tca        8409
Gly Lys  Trp Asn Glu Ala Ser  Gln Ser Tyr Lys Ala  Leu Thr Ser            
    2750                 2755                 2760                        

cca acg  att gcc ggc tac acg  cca agt gaa gcg gta  gta aag cgc        8454
Pro Thr  Ile Ala Gly Tyr Thr  Pro Ser Glu Ala Val  Val Lys Arg            
    2765                 2770                 2775                        

agt tcc  aac agc gat gcc gaa  caa ggc cca acg ctt  acg gtc atc        8499
Ser Ser  Asn Ser Asp Ala Glu  Gln Gly Pro Thr Leu  Thr Val Ile            
    2780                 2785                 2790                        

tac acg  gct gat gcc caa aca  gcc tac gtc aag tac  gtt gat gac        8544
Tyr Thr  Ala Asp Ala Gln Thr  Ala Tyr Val Lys Tyr  Val Asp Asp            
    2795                 2800                 2805                        

acg act  ggc gag acg ctg cgt  caa gac gat ctg cac  ggc tac acg        8589
Thr Thr  Gly Glu Thr Leu Arg  Gln Asp Asp Leu His  Gly Tyr Thr            
    2810                 2815                 2820                        

gat gaa  acg att cca tac agc  acg gct gaa ggc atc  aag aag tac        8634
Asp Glu  Thr Ile Pro Tyr Ser  Thr Ala Glu Gly Ile  Lys Lys Tyr            
    2825                 2830                 2835                        

gaa ggc  gac ggc tac gtt ctg  gta tcg gac ggc ttt  aag cca ggt        8679
Glu Gly  Asp Gly Tyr Val Leu  Val Ser Asp Gly Phe  Lys Pro Gly            
    2840                 2845                 2850                        

act aag  ttc ggt gtt ggc acg  cca acc tat gaa gtt  cac ttc aag        8724
Thr Lys  Phe Gly Val Gly Thr  Pro Thr Tyr Glu Val  His Phe Lys            
    2855                 2860                 2865                        

cat ggc  atg acg cat acc gat  gca acc gac aag aat  gct gaa caa        8769
His Gly  Met Thr His Thr Asp  Ala Thr Asp Lys Asn  Ala Glu Gln            
    2870                 2875                 2880                        

aag acg  gtt acg gaa acg att  cac tac gtt gac gaa  aac aac caa        8814
Lys Thr  Val Thr Glu Thr Ile  His Tyr Val Asp Glu  Asn Asn Gln            
    2885                 2890                 2895                        

acc gtt  cag cca gac tcc acg  aca gca gta acc ttc  aag cgc ggc        8859
Thr Val  Gln Pro Asp Ser Thr  Thr Ala Val Thr Phe  Lys Arg Gly            
    2900                 2905                 2910                        

tac acg  acc gat aac gtt acc  ggc aag gtt gtt tcc  tac gat cca        8904
Tyr Thr  Thr Asp Asn Val Thr  Gly Lys Val Val Ser  Tyr Asp Pro            
    2915                 2920                 2925                        

tgg acg  gtt gat ggt aat cag  gct gac agt aag aca  ttt gct gcc        8949
Trp Thr  Val Asp Gly Asn Gln  Ala Asp Ser Lys Thr  Phe Ala Ala            
    2930                 2935                 2940                        

gta cct  agc cca gca gtc gaa  ggt tac acg cca aac  cac cag caa        8994
Val Pro  Ser Pro Ala Val Glu  Gly Tyr Thr Pro Asn  His Gln Gln            
    2945                 2950                 2955                        

att aac  gaa ttc acc gtt acg  cca gat tca aaa gac  att gtc aag        9039
Ile Asn  Glu Phe Thr Val Thr  Pro Asp Ser Lys Asp  Ile Val Lys            
    2960                 2965                 2970                        

acg gtc  gtt tat gtt ggt gat  ccc caa gaa gct caa  gcc atc ttc        9084
Thr Val  Val Tyr Val Gly Asp  Pro Gln Glu Ala Gln  Ala Ile Phe            
    2975                 2980                 2985                        

tat gat  gaa aca acg ggc aag  gaa atc agc aac acg  cgt gaa atc        9129
Tyr Asp  Glu Thr Thr Gly Lys  Glu Ile Ser Asn Thr  Arg Glu Ile            
    2990                 2995                 3000                        

gta aat  ggc aag act gat gaa  acg atc ggc ttt acc  aag gat cca        9174
Val Asn  Gly Lys Thr Asp Glu  Thr Ile Gly Phe Thr  Lys Asp Pro            
    3005                 3010                 3015                        

aat gaa  gtc gtc aag gaa ctc  gaa aag caa ggt tat  gtc ttt gat        9219
Asn Glu  Val Val Lys Glu Leu  Glu Lys Gln Gly Tyr  Val Phe Asp            
    3020                 3025                 3030                        

aag gac  aat gct aat aac aat  gtc ttt gct gcc ggc  acg acc tac        9264
Lys Asp  Asn Ala Asn Asn Asn  Val Phe Ala Ala Gly  Thr Thr Tyr            
    3035                 3040                 3045                        

gac aag  aat tct gaa gtt cac  caa tac ttc aag tac  tac ttc acg        9309
Asp Lys  Asn Ser Glu Val His  Gln Tyr Phe Lys Tyr  Tyr Phe Thr            
    3050                 3055                 3060                        

cac gct  acg acg atc gtt acg  cca gac aat cca aag  acg ccg gct        9354
His Ala  Thr Thr Ile Val Thr  Pro Asp Asn Pro Lys  Thr Pro Ala            
    3065                 3070                 3075                        

gat gta  ttg ccg gac aac cct  ggc aag aat tac ccg  agc ggt gtt        9399
Asp Val  Leu Pro Asp Asn Pro  Gly Lys Asn Tyr Pro  Ser Gly Val            
    3080                 3085                 3090                        

gcc aag  gat gat ctg aac aag  acc gtt acg cgg acg  atc aac att        9444
Ala Lys  Asp Asp Leu Asn Lys  Thr Val Thr Arg Thr  Ile Asn Ile            
    3095                 3100                 3105                        

acg acg  cca gat ggc aag aca  cag acg atc acg cag  aag gct gaa        9489
Thr Thr  Pro Asp Gly Lys Thr  Gln Thr Ile Thr Gln  Lys Ala Glu            
    3110                 3115                 3120                        

ttt acg  cgg agt gca acg gtt  gat gag gtt acc ggt  gaa gta act        9534
Phe Thr  Arg Ser Ala Thr Val  Asp Glu Val Thr Gly  Glu Val Thr            
    3125                 3130                 3135                        

tat gga  cca tgg tcg aag aat  gtc gtt ttg gaa agc  gtt gac gta        9579
Tyr Gly  Pro Trp Ser Lys Asn  Val Val Leu Glu Ser  Val Asp Val            
    3140                 3145                 3150                        

cca aac  att tct gga tac gtg  cca tct gca tcc gtt  cca gaa att        9624
Pro Asn  Ile Ser Gly Tyr Val  Pro Ser Ala Ser Val  Pro Glu Ile            
    3155                 3160                 3165                        

acg gtt  acg cca aat gat caa  gac atg acg atc aac  atc acc tac        9669
Thr Val  Thr Pro Asn Asp Gln  Asp Met Thr Ile Asn  Ile Thr Tyr            
    3170                 3175                 3180                        

aag aag  ctt gat tct ggc aag  gca gct gac caa ggc  ggc aat gct        9714
Lys Lys  Leu Asp Ser Gly Lys  Ala Ala Asp Gln Gly  Gly Asn Ala            
    3185                 3190                 3195                        

tcc aat  ggt ggt caa gca acg  aat ggc ggt tca acg  act ggt caa        9759
Ser Asn  Gly Gly Gln Ala Thr  Asn Gly Gly Ser Thr  Thr Gly Gln            
    3200                 3205                 3210                        

tcc gct  caa aac ggc cag tca  ggt caa acc caa aac  aat gct ggt        9804
Ser Ala  Gln Asn Gly Gln Ser  Gly Gln Thr Gln Asn  Asn Ala Gly            
    3215                 3220                 3225                        

gct caa  caa ttg cca caa act  ggt aac gcc aac aat  gaa aag ggc        9849
Ala Gln  Gln Leu Pro Gln Thr  Gly Asn Ala Asn Asn  Glu Lys Gly            
    3230                 3235                 3240                        

gca ctg  gga ttg gca agc gca  atg ttc gcc gct ggt  ctt ggc ctg        9894
Ala Leu  Gly Leu Ala Ser Ala  Met Phe Ala Ala Gly  Leu Gly Leu            
    3245                 3250                 3255                        

ggc ttt  ggc tca aag aag aag  tgt cac gaa gac tagatgaaac              9937
Gly Phe  Gly Ser Lys Lys Lys  Cys His Glu Asp                             
    3260                 3265                                             

aataaaatag attcatcaca gataaaaaag actcaacctt tgatttttca aaggttgagc     9997

ctttttgtct tttttcgcaa aga                                            10020


<210>  18
<211>  3269
<212>  PRT
<213>  Lactobacillus reuteri

<400>  18

Met Val Gly Lys Asn Asn Asn Tyr Val Arg Glu Ser Lys Ser Asn Glu 
1               5                   10                  15      


His Phe Gln Arg Phe Ala Leu Arg Lys Leu Ser Val Gly Val Val Ser 
            20                  25                  30          


Val Ala Val Ala Ala Gly Phe Tyr Leu Gly Ser Gly Ala Thr Ala Gln 
        35                  40                  45              


Ala Ala Thr Thr Glu Ser Asn Ala Ser Ala Lys Thr Glu Gln Val Val 
    50                  55                  60                  


Gln Gln Asn Ser Thr Ser Ala Ala Ser Asp Ser Thr Ser Thr Ser Asn 
65                  70                  75                  80  


Ser Ser Ala Ala Val Ser Thr Ser Ser Ala Thr Pro Val Ser Thr Glu 
                85                  90                  95      


Ser Ala Ser Ser Met Thr Val Ser Asp Leu Pro Ala Ser Ala Ser Ala 
            100                 105                 110         


Ala Ser Asp Asn Gln Ala Ser Ala Ala Asn Ala Ser Glu Ser Ser Ser 
        115                 120                 125             


Gln Ser Ala Ser Ser Ser Val Ala Ser Asp Ala Ala Ala Thr Val Ser 
    130                 135                 140                 


Lys Asp Ser Gln Ala Ala Ser Glu Ala Asn Ser Gln Ser Ala Ala Asp 
145                 150                 155                 160 


Val Glu Thr Val Gln Leu Pro Thr Ser Ala Ala Asn Ala Asn Ala Asn 
                165                 170                 175     


Glu Ser Gln Ala Ala Asn Ile Leu Gly Ala Gln Ala Val Gln Lys Ala 
            180                 185                 190         


Ala Asn Gln Gln Ala Pro Ala Gly Phe Thr Val Thr Asp Pro Asn Tyr 
        195                 200                 205             


Pro Ala Glu Met Tyr Lys Asp Pro Asp Ala Ser His Tyr Thr Tyr Trp 
    210                 215                 220                 


Trp Ala Gln Ser Ser Asn Gly Glu Tyr Asn Leu Val Leu Ser Thr Asp 
225                 230                 235                 240 


Arg Asn Gly Asp Gly Lys Val Tyr Val Phe Leu Leu Gly Asn Asn Asn 
                245                 250                 255     


Asn Val Leu Gly Lys Tyr Thr Val Asp Lys Asn Lys Ser Thr Glu Val 
            260                 265                 270         


Ala Thr Asp Asp Glu Gly Asp Phe Gly Thr Val Tyr Asn Asp Gly Gln 
        275                 280                 285             


Ser Gly Val Phe Val Thr Ser Asp Gly Thr Trp Lys Ser Lys Phe Asn 
    290                 295                 300                 


Val Phe Asp Pro Lys Ala Gly Glu Asp Asp Gly Asp Tyr Gly Ser Ile 
305                 310                 315                 320 


Ser Phe Met Ile Pro Gln Val Glu Thr Gln Thr Thr Thr Tyr Val Thr 
                325                 330                 335     


Tyr Phe Asp Ser Lys Gly Asn Lys Val Asp Lys Pro Ile Glu Val Ser 
            340                 345                 350         


Asp Pro Val Ile Gln Lys Gly Leu Asp Gly Gln Ile Tyr Thr Thr Lys 
        355                 360                 365             


Gly Gly Lys Val Ile Asn Gly Tyr Phe Ala Lys Glu Pro Lys Asn Ala 
    370                 375                 380                 


His Gly Phe Met Ser Pro Phe Gly Lys Gln Gly Ala Ile Tyr Thr Lys 
385                 390                 395                 400 


Asp Trp His Asp Gly Leu Lys Ala Thr Phe Thr Glu Thr Asp Thr Lys 
                405                 410                 415     


Thr Gly Leu Met His Val Val Val Lys His Tyr Tyr His Ser Trp Gly 
            420                 425                 430         


Trp Gly Thr Trp Arg Thr Val Lys Glu Phe Asp Leu Ala Pro Gly Gln 
        435                 440                 445             


Ser Glu Lys Val Asp Tyr Asp Val Tyr Lys Ser Val Thr Ile His Ser 
    450                 455                 460                 


Ile Tyr Ile Pro Gln Thr Ile Asn Ile Gln Tyr Thr Tyr Glu Lys Leu 
465                 470                 475                 480 


Gly Asn Leu Val Ile Ser Ser Asp Ser Lys Ser Phe Pro Ala Glu Asp 
                485                 490                 495     


Lys Thr Gln Tyr Pro Asn Asp Lys Ser Asp Ser Thr Lys Ala Gly Asn 
            500                 505                 510         


Val Thr Ile Pro Lys Val Ala Gly Phe Thr Pro Thr Ile Asn Asp Lys 
        515                 520                 525             


Thr Val Thr Asn Tyr Thr Phe Asn Pro Ser Asp Tyr Val Ser Asp Leu 
    530                 535                 540                 


Ser Lys Asp Ile Asn Val Val Tyr Val Ala Asp Thr Gln Glu Ala Ala 
545                 550                 555                 560 


Ile Ser Phe Tyr Asp Glu Thr Asp His Lys Pro Leu Asn Asp Gln Thr 
                565                 570                 575     


Ile Gln Leu Thr Gly Lys Thr Gly Glu Lys Ile Ser His Thr Glu Ala 
            580                 585                 590         


Asn Gln Thr Leu Ala Lys Leu Gly Lys Gln Gly Tyr Val Val Asp Gln 
        595                 600                 605             


Asn Thr Phe Ala Asp Asp Ala Thr Tyr Asp Asn Asp Thr Gln Ala Pro 
    610                 615                 620                 


Gln Glu Phe Thr Ile Tyr Leu Lys His Asp Thr Thr His Thr Asp Ala 
625                 630                 635                 640 


Thr Ser Ser Lys Ala Asp Gln Lys Thr Val Ser Glu Thr Ile His Tyr 
                645                 650                 655     


Val Tyr Lys Asp Gly Val Asn Ala Asn Lys Pro Val Ala Asp Asp Ala 
            660                 665                 670         


Asn Thr Thr Val Thr Phe Lys Arg Gly Tyr Thr Thr Asp Lys Val Thr 
        675                 680                 685             


Gly Lys Ile Val Ser Tyr Asp Pro Trp Thr Val Asp Gly Lys Gln Ala 
    690                 695                 700                 


Asp Ser Lys Thr Phe Asp Ala Val Lys Ser Pro Val Ile Ala Gly Tyr 
705                 710                 715                 720 


Thr Ala Asp Gln Ala Glu Val Ala Ala Gln Thr Val Thr Pro Asp Ser 
                725                 730                 735     


Gln Asn Ile Asn Lys Thr Val Tyr Tyr Thr Ala Asp Thr Gln Glu Ala 
            740                 745                 750         


Ala Ile Asn Phe Tyr Asp Glu Thr Gly His Lys Leu Leu Asp Asn Gln 
        755                 760                 765             


Thr Ile His Leu Thr Gly Lys Thr Gly Glu Lys Val Asp Arg Thr Gln 
    770                 775                 780                 


Ala Asp Gln Thr Leu Ala Asp Leu Val Lys Gln Gly Tyr Val Leu Asp 
785                 790                 795                 800 


Lys Glu Asn Thr Ala Lys Ala Phe Pro Ala Asp Ala Val Tyr Asp Asn 
                805                 810                 815     


Asn Asp Gln Thr Pro Gln Glu Phe Thr Ile Tyr Leu Lys His Gly Thr 
            820                 825                 830         


Thr His Thr Asp Ala Thr Ser Ser Lys Ala Asp Gln Lys Thr Val Ser 
        835                 840                 845             


Glu Thr Ile His Tyr Val Tyr Lys Asp Gly Val Asn Ala Asn Lys Pro 
    850                 855                 860                 


Val Ala Asp Asp Ala Asn Thr Thr Val Thr Phe Lys Arg Gly Tyr Thr 
865                 870                 875                 880 


Thr Asp Lys Val Thr Gly Lys Ile Val Ser Tyr Asp Pro Trp Thr Val 
                885                 890                 895     


Asp Gly Lys Gln Ala Asp Ser Lys Thr Phe Asp Ala Val Lys Ser Pro 
            900                 905                 910         


Val Ile Ala Gly Tyr Thr Ala Asp Gln Ala Glu Val Ala Ala Gln Thr 
        915                 920                 925             


Val Thr Pro Asp Ser Gln Asn Ile Asn Lys Thr Val Tyr Tyr Thr Ala 
    930                 935                 940                 


Asp Thr Gln Glu Ala Ala Ile Asn Phe Tyr Asp Glu Thr Gly His Lys 
945                 950                 955                 960 


Leu Leu Asp Asn Gln Thr Ile His Leu Thr Gly Lys Thr Gly Glu Lys 
                965                 970                 975     


Val Asp Arg Thr Gln Ala Asp Gln Thr Leu Ala Glu Leu Glu Lys Gln 
            980                 985                 990         


Gly Tyr Val Leu Asp Glu Asn Asn  Thr Lys Leu Gly Phe  Pro Ser Asn 
        995                 1000                 1005             


Ala Ala  Tyr Asp Asp Asp Asp  Val Lys Pro Gln Glu  Phe Thr Ile 
    1010                 1015                 1020             


Tyr Leu  Lys His Gly Met Thr  His Thr Asp Ala Thr  Asp Lys Asn 
    1025                 1030                 1035             


Ala Glu  Gln Lys Ile Val Thr  Glu Thr Ile His Tyr  Val Tyr Glu 
    1040                 1045                 1050             


Asn Asn  Gln Thr Ala Lys Thr  Asp Tyr Thr Ser Ala  Val Asp Phe 
    1055                 1060                 1065             


Lys Arg  Gly Tyr Thr Thr Asp  Asn Val Thr His Lys  Ile Ile Ser 
    1070                 1075                 1080             


Tyr Asp  Pro Trp Met Val Ser  Ser Lys Lys Phe Gly  Phe Val Lys 
    1085                 1090                 1095             


Ser Pro  Ala Ile Glu Gly Tyr  Thr Pro Asn His Ser  Gln Ile Asp 
    1100                 1105                 1110             


Glu Ile  Thr Val Thr Pro Asp  Ser Lys Asp Val Val  Lys Thr Val 
    1115                 1120                 1125             


Val Tyr  Val Gly Asn Ala Gln  Glu Ala Gln Ala Ile  Phe Tyr Asp 
    1130                 1135                 1140             


Glu Thr  Thr Gly Lys Glu Ile  Ser Gly Thr Arg Glu  Ile Ala Thr 
    1145                 1150                 1155             


Gly Lys  Thr Asp Glu Thr Ile  Ser Phe Thr Lys Asp  Pro Asn Glu 
    1160                 1165                 1170             


Val Val  Lys Glu Leu Glu Lys  Gln Gly Tyr Val Phe  Asp Lys Asp 
    1175                 1180                 1185             


Asn Ala  Lys Asn Asn Val Phe  Val Ala Gly Thr Ala  Tyr Asp Lys 
    1190                 1195                 1200             


Asn Ser  Glu Val His Gln Tyr  Phe Lys Tyr Tyr Leu  Lys His Gly 
    1205                 1210                 1215             


His Ala  Thr Val Thr Pro Asp  Gln Asp Pro Gln Lys  Gly Gln Lys 
    1220                 1225                 1230             


Thr Val  Thr Gln Thr Ile Lys  Tyr Glu Tyr Ala Asp  Gly Thr Ala 
    1235                 1240                 1245             


Thr Gly  Leu Ala Asp Asn Val  Gln Thr Leu Thr Phe  Lys Arg Thr 
    1250                 1255                 1260             


Gly Asp  Lys Asp Leu Val Thr  His Glu Val Thr Trp  Pro Asp Trp 
    1265                 1270                 1275             


Ser Thr  Val Ala Gly Gln Gln  Thr Ser Val Val Thr  Ser Pro Ala 
    1280                 1285                 1290             


Leu Lys  Gly Tyr Thr Ala Asp  Thr Asn Glu Ile Pro  Ala Ile Thr 
    1295                 1300                 1305             


Tyr His  Ala Gly Asp Ser Asp  Val Thr Tyr Val Val  Lys Tyr Asn 
    1310                 1315                 1320             


Ala Asp  Val Gln His Ala Val  Ile Asn Tyr Ile Asp  Gly Glu Ser 
    1325                 1330                 1335             


Asp Glu  Ile Leu His Thr Asp  Lys Val Asn Gly His  Ser Asp Glu 
    1340                 1345                 1350             


Lys Ile  Asn Tyr Ser Thr Ala  Asp Met Ile Lys Gln  Leu Glu Ala 
    1355                 1360                 1365             


Lys Gly  Tyr Glu Leu Phe Lys  Asp Asn Phe Pro Ala  Gly Glu Lys 
    1370                 1375                 1380             


Phe Asp  Asn Asp Asp Thr Asn  Asp Gln Phe Tyr Thr  Val Ile Phe 
    1385                 1390                 1395             


Lys His  His Arg Glu Asn Val  Asp Pro Asn His Ser  Ser Ala Asp 
    1400                 1405                 1410             


Gly Thr  Lys Gly Thr Lys Thr  Leu Thr Glu Thr Val  His Tyr Lys 
    1415                 1420                 1425             


Tyr Ala  Asn Gly Thr Lys Ala  Ala Glu Asp Gln Thr  Ala Gln Val 
    1430                 1435                 1440             


Thr Phe  Thr Arg Asn Gly Val  Leu Asp Asp Val Thr  Gly Ile Val 
    1445                 1450                 1455             


Ala Trp  Gly Lys Trp Asn Glu  Ala Ser Gln Ser Tyr  Lys Ala Leu 
    1460                 1465                 1470             


Thr Ser  Pro Thr Ile Ala Gly  Tyr Ala Pro Ser Glu  Ala Val Val 
    1475                 1480                 1485             


Lys Arg  Ser Ser Asn Ser Asp  Ala Glu Gln Gly Pro  Thr Leu Thr 
    1490                 1495                 1500             


Val Ile  Tyr Thr Ala Asp Ala  Gln Lys Val His Val  Gln Tyr Ile 
    1505                 1510                 1515             


Asp Gly  Glu Thr Asp Gln Met  Leu Arg Gln Asp Asp  Leu Asp Gly 
    1520                 1525                 1530             


Tyr Thr  Asp Glu Thr Ile Pro  Tyr Ser Thr Ala Glu  Gly Ile Lys 
    1535                 1540                 1545             


Lys Phe  Glu Gly Asp Gly Tyr  Glu Leu Phe Lys Asp  Asn Phe Pro 
    1550                 1555                 1560             


Ala Gly  Glu Lys Phe Asp Asn  Asp Asp Lys Asn Asp  Gln Thr Tyr 
    1565                 1570                 1575             


Thr Val  Ile Phe Lys His His  Arg Glu Asn Val Asp  Pro Asn His 
    1580                 1585                 1590             


Ser Ser  Ala Asp Gly Thr Lys  Gly Thr Lys Thr Leu  Thr Glu Thr 
    1595                 1600                 1605             


Val His  Tyr Lys Tyr Ala Asp  Gly Thr Lys Ala Ala  Glu Asp Gln 
    1610                 1615                 1620             


Thr Ala  Gln Val Thr Phe Thr  Arg Asn Gly Val Leu  Asp Asp Val 
    1625                 1630                 1635             


Thr Gly  Ile Val Ala Trp Gly  Lys Trp Asn Glu Ala  Ser Gln Ser 
    1640                 1645                 1650             


Tyr Lys  Ala Leu Thr Ser Pro  Thr Ile Ala Gly Tyr  Thr Pro Ser 
    1655                 1660                 1665             


Glu Ala  Val Val Lys Arg Ser  Ser Asn Ser Asp Ala  Glu Gln Gly 
    1670                 1675                 1680             


Pro Thr  Leu Thr Val Ile Tyr  Thr Ala Asp Ala Gln  Lys Val His 
    1685                 1690                 1695             


Val Gln  Tyr Ile Asp Gly Glu  Thr Asp Gln Met Leu  Arg Gln Asp 
    1700                 1705                 1710             


Asp Leu  Asp Gly Tyr Thr Asp  Glu Thr Ile Pro Tyr  Ser Thr Ala 
    1715                 1720                 1725             


Glu Gly  Ile Lys Lys Phe Glu  Gly Asp Gly Tyr Glu  Leu Phe Lys 
    1730                 1735                 1740             


Asp Asn  Phe Pro Ala Gly Glu  Lys Phe Asp Asn Asp  Asp Thr Asn 
    1745                 1750                 1755             


Asp Gln  Phe Tyr Thr Val Ile  Phe Lys His His Arg  Glu Asn Val 
    1760                 1765                 1770             


Asp Pro  Asn His Ser Ser Ala  Asp Gly Thr Lys Gly  Thr Lys Thr 
    1775                 1780                 1785             


Leu Thr  Glu Thr Val His Tyr  Lys Tyr Ala Asn Gly  Thr Lys Ala 
    1790                 1795                 1800             


Ala Glu  Asp Gln Thr Ala Gln  Val Thr Phe Thr Arg  Asn Gly Val 
    1805                 1810                 1815             


Leu Asp  Asp Val Thr Gly Ile  Val Ala Trp Gly Lys  Trp Asn Glu 
    1820                 1825                 1830             


Ala Ser  Gln Ser Tyr Lys Ala  Leu Thr Ser Pro Thr  Ile Ala Gly 
    1835                 1840                 1845             


Tyr Ala  Pro Ser Glu Ala Val  Val Lys Arg Ser Ser  Asn Ser Asp 
    1850                 1855                 1860             


Ala Glu  Gln Gly Pro Thr Leu  Thr Val Ile Tyr Thr  Ala Asp Ala 
    1865                 1870                 1875             


Gln Lys  Val His Val Gln Tyr  Ile Asp Gly Glu Thr  Asp Gln Met 
    1880                 1885                 1890             


Leu Arg  Gln Asp Asp Leu Asp  Gly Tyr Thr Asp Glu  Thr Ile Pro 
    1895                 1900                 1905             


Tyr Ser  Thr Ala Glu Gly Ile  Lys Lys Phe Glu Gly  Asp Gly Tyr 
    1910                 1915                 1920             


Glu Leu  Phe Lys Asp Asn Phe  Pro Ala Gly Glu Lys  Phe Asp Asn 
    1925                 1930                 1935             


Asp Asp  Lys Asn Asp Gln Thr  Tyr Thr Val Ile Phe  Lys His His 
    1940                 1945                 1950             


Arg Glu  Asn Val Asp Pro Asn  His Ser Ser Ala Asp  Gly Thr Lys 
    1955                 1960                 1965             


Gly Thr  Lys Thr Leu Thr Glu  Thr Val His Tyr Lys  Tyr Ala Asp 
    1970                 1975                 1980             


Gly Thr  Lys Ala Ala Glu Asp  Gln Thr Ala Gln Val  Thr Phe Thr 
    1985                 1990                 1995             


Arg Asn  Gly Val Leu Asp Asp  Val Thr Gly Ile Val  Ala Trp Gly 
    2000                 2005                 2010             


Lys Trp  Asn Glu Ala Ser Gln  Ser Tyr Lys Ala Leu  Thr Ser Pro 
    2015                 2020                 2025             


Thr Ile  Ala Gly Tyr Thr Pro  Ser Glu Ala Val Val  Lys Arg Ser 
    2030                 2035                 2040             


Ser Asn  Ser Asp Ala Glu Gln  Gly Pro Thr Leu Thr  Val Ile Tyr 
    2045                 2050                 2055             


Thr Ala  Asp Ala Gln Lys Val  His Val Gln Tyr Ile  Asp Gly Glu 
    2060                 2065                 2070             


Thr Asp  Gln Met Leu Arg Gln  Asp Asp Leu Asp Gly  Tyr Thr Asp 
    2075                 2080                 2085             


Glu Thr  Ile Pro Tyr Ser Thr  Ala Glu Gly Ile Lys  Lys Phe Glu 
    2090                 2095                 2100             


Gly Asp  Gly Tyr Glu Leu Phe  Lys Asp Asn Phe Pro  Ala Gly Glu 
    2105                 2110                 2115             


Lys Phe  Asp Asn Asp Asp Thr  Asn Asp Gln Phe Tyr  Thr Val Ile 
    2120                 2125                 2130             


Phe Lys  His His Arg Glu Asn  Val Asp Pro Asn His  Ser Ser Ala 
    2135                 2140                 2145             


Asp Gly  Thr Lys Gly Thr Lys  Thr Leu Thr Glu Thr  Val His Tyr 
    2150                 2155                 2160             


Lys Tyr  Ala Asn Gly Thr Lys  Ala Ala Glu Asp Gln  Thr Ala Gln 
    2165                 2170                 2175             


Val Thr  Phe Thr Arg Asn Gly  Val Leu Asp Asp Val  Thr Gly Ile 
    2180                 2185                 2190             


Val Ala  Trp Gly Lys Trp Asn  Glu Ala Ser Gln Ser  Tyr Lys Ala 
    2195                 2200                 2205             


Leu Thr  Ser Pro Thr Ile Ala  Gly Tyr Ala Pro Ser  Glu Ala Val 
    2210                 2215                 2220             


Val Lys  Arg Ser Ser Asn Ser  Asp Ala Glu Gln Gly  Pro Thr Leu 
    2225                 2230                 2235             


Thr Val  Ile Tyr Thr Ala Asp  Ala Gln Lys Val His  Val Gln Tyr 
    2240                 2245                 2250             


Ile Asp  Gly Glu Thr Asp Gln  Met Leu Arg Gln Asp  Asp Leu Asp 
    2255                 2260                 2265             


Gly Tyr  Thr Asp Glu Thr Ile  Pro Tyr Ser Thr Ala  Glu Gly Ile 
    2270                 2275                 2280             


Lys Lys  Phe Glu Gly Asp Gly  Tyr Glu Leu Phe Lys  Asp Asn Phe 
    2285                 2290                 2295             


Pro Ala  Gly Glu Lys Phe Asp  Asn Asp Asp Lys Asn  Asp Gln Thr 
    2300                 2305                 2310             


Tyr Thr  Val Ile Phe Lys His  His Arg Glu Asn Val  Asp Pro Asn 
    2315                 2320                 2325             


His Ser  Ser Ala Asp Gly Thr  Lys Gly Thr Lys Thr  Leu Thr Glu 
    2330                 2335                 2340             


Thr Val  His Tyr Lys Tyr Ala  Asp Gly Thr Lys Ala  Ala Glu Asp 
    2345                 2350                 2355             


Gln Thr  Ala Gln Val Thr Phe  Thr Arg Asn Gly Val  Leu Asp Asp 
    2360                 2365                 2370             


Val Thr  Gly Ile Val Ala Trp  Gly Lys Trp Asn Glu  Ala Ser Gln 
    2375                 2380                 2385             


Ser Tyr  Lys Ala Leu Thr Ser  Pro Thr Ile Ala Gly  Tyr Thr Pro 
    2390                 2395                 2400             


Ser Glu  Ala Val Val Lys Arg  Ser Ser Asn Ser Asp  Ala Glu Gln 
    2405                 2410                 2415             


Gly Pro  Thr Leu Thr Val Ile  Tyr Thr Ala Asp Ala  Gln Lys Val 
    2420                 2425                 2430             


His Val  Gln Tyr Ile Asp Gly  Glu Thr Asp Gln Met  Leu Arg Gln 
    2435                 2440                 2445             


Asp Asp  Leu Asp Gly Tyr Thr  Asp Glu Thr Ile Pro  Tyr Ser Thr 
    2450                 2455                 2460             


Ala Glu  Gly Ile Lys Lys Phe  Glu Gly Asp Gly Tyr  Glu Leu Phe 
    2465                 2470                 2475             


Lys Asp  Asn Phe Pro Ala Gly  Glu Lys Phe Asp Asn  Asp Asp Lys 
    2480                 2485                 2490             


Thr Asp  Gln Thr Tyr Thr Val  Ile Phe Lys His His  Arg Glu Asn 
    2495                 2500                 2505             


Val Asp  Pro Asn His Ser Ser  Ala Asp Gly Thr Lys  Gly Thr Lys 
    2510                 2515                 2520             


Thr Leu  Thr Glu Thr Val His  Tyr Lys Tyr Ala Asp  Gly Thr Lys 
    2525                 2530                 2535             


Ala Ala  Glu Asp Gln Thr Ala  Gln Val Thr Phe Thr  Arg Asn Gly 
    2540                 2545                 2550             


Val Leu  Asp Asp Val Thr Gly  Ile Val Ala Trp Gly  Lys Trp Asn 
    2555                 2560                 2565             


Glu Ala  Ser Gln Ser Tyr Lys  Ala Leu Thr Ser Pro  Thr Ile Ala 
    2570                 2575                 2580             


Gly Tyr  Thr Pro Ser Glu Ala  Val Val Lys Arg Ser  Ser Asn Ser 
    2585                 2590                 2595             


Asp Ala  Glu Gln Gly Pro Thr  Leu Thr Val Ile Tyr  Thr Ala Asp 
    2600                 2605                 2610             


Ala Gln  Thr Ala Tyr Val Lys  Tyr Val Asp Asp Thr  Thr Gly Glu 
    2615                 2620                 2625             


Thr Leu  Arg Gln Asp Asp Leu  His Gly Tyr Thr Asp  Glu Thr Ile 
    2630                 2635                 2640             


Pro Tyr  Ser Thr Ala Glu Gly  Ile Lys Lys Phe Glu  Gly Asp Gly 
    2645                 2650                 2655             


Tyr Glu  Leu Phe Lys Asp Asn  Phe Pro Ala Gly Glu  Lys Phe Asp 
    2660                 2665                 2670             


Asn Asp  Asp Lys Thr Asp Gln  Thr Tyr Thr Val Ile  Phe Lys His 
    2675                 2680                 2685             


His Arg  Glu Asn Val Asp Pro  Asn His Ser Ser Ala  Asp Gly Thr 
    2690                 2695                 2700             


Lys Gly  Thr Lys Thr Leu Thr  Glu Thr Val His Tyr  Lys Tyr Ala 
    2705                 2710                 2715             


Asp Gly  Thr Lys Ala Ala Glu  Asp Gln Thr Ala Gln  Val Thr Phe 
    2720                 2725                 2730             


Thr Arg  Asn Gly Val Leu Asp  Asp Val Thr Gly Ile  Val Ala Trp 
    2735                 2740                 2745             


Gly Lys  Trp Asn Glu Ala Ser  Gln Ser Tyr Lys Ala  Leu Thr Ser 
    2750                 2755                 2760             


Pro Thr  Ile Ala Gly Tyr Thr  Pro Ser Glu Ala Val  Val Lys Arg 
    2765                 2770                 2775             


Ser Ser  Asn Ser Asp Ala Glu  Gln Gly Pro Thr Leu  Thr Val Ile 
    2780                 2785                 2790             


Tyr Thr  Ala Asp Ala Gln Thr  Ala Tyr Val Lys Tyr  Val Asp Asp 
    2795                 2800                 2805             


Thr Thr  Gly Glu Thr Leu Arg  Gln Asp Asp Leu His  Gly Tyr Thr 
    2810                 2815                 2820             


Asp Glu  Thr Ile Pro Tyr Ser  Thr Ala Glu Gly Ile  Lys Lys Tyr 
    2825                 2830                 2835             


Glu Gly  Asp Gly Tyr Val Leu  Val Ser Asp Gly Phe  Lys Pro Gly 
    2840                 2845                 2850             


Thr Lys  Phe Gly Val Gly Thr  Pro Thr Tyr Glu Val  His Phe Lys 
    2855                 2860                 2865             


His Gly  Met Thr His Thr Asp  Ala Thr Asp Lys Asn  Ala Glu Gln 
    2870                 2875                 2880             


Lys Thr  Val Thr Glu Thr Ile  His Tyr Val Asp Glu  Asn Asn Gln 
    2885                 2890                 2895             


Thr Val  Gln Pro Asp Ser Thr  Thr Ala Val Thr Phe  Lys Arg Gly 
    2900                 2905                 2910             


Tyr Thr  Thr Asp Asn Val Thr  Gly Lys Val Val Ser  Tyr Asp Pro 
    2915                 2920                 2925             


Trp Thr  Val Asp Gly Asn Gln  Ala Asp Ser Lys Thr  Phe Ala Ala 
    2930                 2935                 2940             


Val Pro  Ser Pro Ala Val Glu  Gly Tyr Thr Pro Asn  His Gln Gln 
    2945                 2950                 2955             


Ile Asn  Glu Phe Thr Val Thr  Pro Asp Ser Lys Asp  Ile Val Lys 
    2960                 2965                 2970             


Thr Val  Val Tyr Val Gly Asp  Pro Gln Glu Ala Gln  Ala Ile Phe 
    2975                 2980                 2985             


Tyr Asp  Glu Thr Thr Gly Lys  Glu Ile Ser Asn Thr  Arg Glu Ile 
    2990                 2995                 3000             


Val Asn  Gly Lys Thr Asp Glu  Thr Ile Gly Phe Thr  Lys Asp Pro 
    3005                 3010                 3015             


Asn Glu  Val Val Lys Glu Leu  Glu Lys Gln Gly Tyr  Val Phe Asp 
    3020                 3025                 3030             


Lys Asp  Asn Ala Asn Asn Asn  Val Phe Ala Ala Gly  Thr Thr Tyr 
    3035                 3040                 3045             


Asp Lys  Asn Ser Glu Val His  Gln Tyr Phe Lys Tyr  Tyr Phe Thr 
    3050                 3055                 3060             


His Ala  Thr Thr Ile Val Thr  Pro Asp Asn Pro Lys  Thr Pro Ala 
    3065                 3070                 3075             


Asp Val  Leu Pro Asp Asn Pro  Gly Lys Asn Tyr Pro  Ser Gly Val 
    3080                 3085                 3090             


Ala Lys  Asp Asp Leu Asn Lys  Thr Val Thr Arg Thr  Ile Asn Ile 
    3095                 3100                 3105             


Thr Thr  Pro Asp Gly Lys Thr  Gln Thr Ile Thr Gln  Lys Ala Glu 
    3110                 3115                 3120             


Phe Thr  Arg Ser Ala Thr Val  Asp Glu Val Thr Gly  Glu Val Thr 
    3125                 3130                 3135             


Tyr Gly  Pro Trp Ser Lys Asn  Val Val Leu Glu Ser  Val Asp Val 
    3140                 3145                 3150             


Pro Asn  Ile Ser Gly Tyr Val  Pro Ser Ala Ser Val  Pro Glu Ile 
    3155                 3160                 3165             


Thr Val  Thr Pro Asn Asp Gln  Asp Met Thr Ile Asn  Ile Thr Tyr 
    3170                 3175                 3180             


Lys Lys  Leu Asp Ser Gly Lys  Ala Ala Asp Gln Gly  Gly Asn Ala 
    3185                 3190                 3195             


Ser Asn  Gly Gly Gln Ala Thr  Asn Gly Gly Ser Thr  Thr Gly Gln 
    3200                 3205                 3210             


Ser Ala  Gln Asn Gly Gln Ser  Gly Gln Thr Gln Asn  Asn Ala Gly 
    3215                 3220                 3225             


Ala Gln  Gln Leu Pro Gln Thr  Gly Asn Ala Asn Asn  Glu Lys Gly 
    3230                 3235                 3240             


Ala Leu  Gly Leu Ala Ser Ala  Met Phe Ala Ala Gly  Leu Gly Leu 
    3245                 3250                 3255             


Gly Phe  Gly Ser Lys Lys Lys  Cys His Glu Asp 
    3260                 3265                 


<210>  19
<211>  164
<212>  PRT
<213>  Lactobacillus gasseri


<220>
<221>  source
<222>  (1)..(164)
<223>  MUB200

<400>  19

Thr Val Thr Tyr Lys Ala Asn Pro Gln Lys Ile Thr Val Asn Tyr Ile 
1               5                   10                  15      


Asp Asp Thr Thr Gly Lys Thr Leu Ser Thr Lys Asp Leu Asn Gly Lys 
            20                  25                  30          


Ser Asp Glu Lys Ser Asp Tyr Ala Thr Lys Asp Ser Ile Ala Glu Tyr 
        35                  40                  45              


Glu Lys Gln His Tyr Asp Leu Val Ser Asp Glu Thr Asn Gly Ser Glu 
    50                  55                  60                  


Leu Val Phe Asp His Asp Asp Lys Val Asp Gln Val Tyr Asn Val His 
65                  70                  75                  80  


Phe Thr His His Met Thr Ser Ile Asn Asp Thr Lys Lys Ile Asn Glu 
                85                  90                  95      


Thr Ile His Tyr Val Tyr Glu Asp Gly Thr Lys Ala His Asp Asp Ile 
            100                 105                 110         


Asn Gly Gln Pro Val Ile Phe Thr His Asp Gly Glu Arg Asp Glu Val 
        115                 120                 125             


Thr Asn Lys Glu His Trp Asn Asp Trp Lys Ser Glu Lys Asp Ser Phe 
    130                 135                 140                 


Asp Glu Val Asn Ser Pro Lys Ile Ala Gly Tyr Thr Pro Asp Phe Ala 
145                 150                 155                 160 


Thr Ile Glu Lys 
                


<210>  20
<211>  152
<212>  PRT
<213>  Lactobacillus johnsonii


<220>
<221>  source
<222>  (1)..(152)
<223>  MUB200

<400>  20

Ile Tyr Ser Pro Asp Ala Gln His Met Ile Ile Thr Tyr Val Asp Asp 
1               5                   10                  15      


Thr Thr Gly Glu Ile Leu Arg Thr Asp Lys Arg Asp Gly Phe Ser Asp 
            20                  25                  30          


Gln Asp Ala Lys Tyr Thr Thr Gly Asp Thr Ile Lys Gln Tyr Glu Asp 
        35                  40                  45              


Gln His Tyr Lys Leu Val Ser Asp Ser Thr Lys Gly Gln Pro Leu Ile 
    50                  55                  60                  


Phe Asp His Asp Asp Asn Val Asp Gln Thr Tyr Glu Val His Leu Lys 
65                  70                  75                  80  


His Ser Thr Glu Asn Val Thr Arg Asn Asp Thr Val Thr Arg Thr Ile 
                85                  90                  95      


His Tyr Leu Tyr Asp Asn Gly Asn Thr Ala Lys Pro Asp Lys Thr Gln 
            100                 105                 110         


Thr Val Ser Phe Asn Glu Thr Gly Thr Lys Asp Asp Val Thr Gly Lys 
        115                 120                 125             


Thr Thr Trp Asp Asn Asp Asn Ala Gln Ser Val Asp Ser Val Ile Thr 
    130                 135                 140                 


Pro Ser Ile Thr Gly Tyr Thr Pro 
145                 150         


<210>  21
<211>  168
<212>  PRT
<213>  Lactobacillus fermentum


<220>
<221>  source
<222>  (1)..(168)
<223>  MUB200

<400>  21

Thr Ile Thr Tyr Thr Ala Asp Thr Gln Lys Gly Ser Val Ser Tyr Val 
1               5                   10                  15      


Asp Asp Thr Thr Gly Lys Thr Leu Lys Thr Asp Ser Ile Ser Gly Thr 
            20                  25                  30          


Thr Gly Ser Lys Ser Ser Tyr Ser Thr Ser Gly Ser Ile Ala Asp Tyr 
        35                  40                  45              


Lys Lys Gln Gly Tyr Glu Leu Val Thr Asp Gly Tyr Pro Ala Asp Leu 
    50                  55                  60                  


Thr Phe Asp Asn Asp Asp Thr Lys Asp Gln Asn Phe Thr Val His Leu 
65                  70                  75                  80  


Lys His Gln Asn Ile Gln Ser Thr Glu Ala Lys Thr Val Thr Glu Thr 
                85                  90                  95      


Ile His Tyr Gln Gly Ala Gly Asn Gln Thr Pro Ala Asp Ser Ala Asp 
            100                 105                 110         


Gln Ser Phe Ala Ala Val Thr Ser Pro Val Ile Lys Gly Tyr Thr Ala 
        115                 120                 125             


Asp Lys Ala Gln Ile Asp Lys Gln Thr Val Asn Gly Asp Ser Lys Asn 
    130                 135                 140                 


Thr Ala Gln Val Thr Phe Thr Arg Gln Val Ser Thr Asp Ala Val Thr 
145                 150                 155                 160 


Gly Glu Lys Thr Tyr Gly Ser Trp 
                165             


<210>  22
<211>  182
<212>  PRT
<213>  Lactobacillus acidophilus


<220>
<221>  source
<222>  (1)..(182)
<223>  MUB200

<400>  22

Val Val Pro Ala Lys Asp Gln Ala Ala Val Val Asn Tyr Val Asp Ala 
1               5                   10                  15      


Asp Glu Asp Asn Lys Leu Ile Thr Ser Ser Gly Asp Leu Thr Gly Lys 
            20                  25                  30          


Ala Gly Glu Thr Ile Asn Tyr Ser Thr Ala Asp Thr Ile Lys Asp Leu 
        35                  40                  45              


Glu Asn Lys Gly Tyr Val Leu Val Asn Asp Gly Phe Pro Ala Gly Ala 
    50                  55                  60                  


Lys Tyr Asp Ser Asp Asp Asn Thr Thr Gln Ile Tyr Thr Val Val Leu 
65                  70                  75                  80  


Lys His Gly Thr Thr Thr Ile Thr Pro Asp Lys Pro Gly Lys Pro Gly 
                85                  90                  95      


Glu Pro Ile Asn Pro Asn Asp Pro Asp Gly Pro Lys Trp Pro Asp Asn 
            100                 105                 110         


Ser Gly Glu Asn Asn Leu Ser Lys Thr Gly Thr Gln Thr Ile His Tyr 
        115                 120                 125             


Thr Gly Ala Gly Asp Lys Thr Pro Glu Asp Asn Lys Gln Glu Phe Thr 
    130                 135                 140                 


Phe Thr Lys Thr Met Val Val Asp Asn Val Thr Gly Lys Val Ile Thr 
145                 150                 155                 160 


Asp Gly Ala Trp Asn Val Thr Ser His Thr Phe Gly Asn Val Asp Thr 
                165                 170                 175     


Pro Val Ile Asp Gly Tyr 
            180         


<210>  23
<211>  70
<212>  PRT
<213>  Lactobacillus acidophilus


<220>
<221>  source
<222>  (1)..(70)
<223>  NCFM

<400>  23

Val Asn Tyr Val Asp Ala Asp Glu Asp Asn Lys Leu Ile Thr Ser Ser 
1               5                   10                  15      


Gly Asp Leu Thr Gly Lys Ala Gly Glu Thr Ile Asn Tyr Ser Thr Ala 
            20                  25                  30          


Asp Thr Ile Lys Asp Leu Glu Asn Lys Gly Tyr Val Leu Val Asn Asp 
        35                  40                  45              


Gly Phe Pro Ala Gly Ala Lys Tyr Asp Ser Asp Asp Asn Thr Thr Gln 
    50                  55                  60                  


Ile Tyr Thr Val Val Leu 
65                  70  


<210>  24
<211>  68
<212>  PRT
<213>  Streptococcus salivarius


<220>
<221>  source
<222>  (1)..(68)
<223>  SK126

<400>  24

Ile Thr Tyr Val Asp Gln Thr Thr Gly Gln Thr Leu Ala Asn Asp Gln 
1               5                   10                  15      


Val Gly Gly Lys Ser Gly Glu Ala Ile Asn Tyr Ser Thr Ala Asp Lys 
            20                  25                  30          


Ile Lys Tyr Tyr Glu Asp Arg Gly Tyr Val Leu Val Ser Asp Glu Phe 
        35                  40                  45              


Pro Thr Gly Ala His Phe Asp Asn Asp Ala Ser Val Asp Gln Thr Trp 
    50                  55                  60                  


Thr Val Thr Leu 
65              


<210>  25
<211>  70
<212>  PRT
<213>  Lactobacillus johnsonii


<220>
<221>  source
<222>  (1)..(70)
<223>  NCC 533

<400>  25

Val Asn Tyr Ile Asp Ala Asp Asp Asn Asn Ala Ile Ile Thr Ser Ser 
1               5                   10                  15      


Asp Asn Leu Thr Gly Lys Ala Gly Glu Lys Ile Asp Tyr Ser Thr Ala 
            20                  25                  30          


Ser Thr Ile Glu Glu Leu Glu Asn Lys Gly Tyr Val Leu Val Ser Asp 
        35                  40                  45              


Gly Phe Pro Ala Gly Ala Thr Phe Asp Asn Asp Asp Asn Thr Thr Gln 
    50                  55                  60                  


Ile Tyr Thr Val Val Leu 
65                  70  


<210>  26
<211>  68
<212>  PRT
<213>  Streptococcus salivarius


<220>
<221>  source
<222>  (1)..(68)
<223>  SK126

<400>  26

Ile Thr Tyr Val Asp Gln Thr Thr Gly Gln Thr Leu Ala Asn Asp Gln 
1               5                   10                  15      


Val Gly Gly Lys Ser Gly Glu Ala Ile Asn Tyr Ser Thr Ala Asp Lys 
            20                  25                  30          


Ile Lys Tyr Tyr Glu Asp Arg Gly Tyr Val Leu Val Ser Asp Glu Phe 
        35                  40                  45              


Pro Lys Gly Ala His Phe Asp Asn Asp Ala Ser Val Asp Gln Ile Trp 
    50                  55                  60                  


Thr Val Thr Leu 
65              


<210>  27
<211>  68
<212>  PRT
<213>  Streptococcus salivarius


<220>
<221>  source
<222>  (1)..(68)
<223>  SK126

<400>  27

Ile Thr Tyr Val Asp Gln Thr Thr Ser Gln Thr Leu Ala Asn Asp Gln 
1               5                   10                  15      


Val Gly Gly Lys Ser Gly Glu Ala Ile Asn Tyr Ser Thr Ala Asp Lys 
            20                  25                  30          


Ile Lys Tyr Tyr Glu Asp Arg Gly Tyr Val Leu Val Ser Asp Glu Phe 
        35                  40                  45              


Pro Thr Gly Ala His Phe Asp Asn Asp Ala Ser Val Asp Gln Thr Trp 
    50                  55                  60                  


Thr Val Thr Leu 
65              


<210>  28
<211>  70
<212>  PRT
<213>  Lactobacillus reuteri


<220>
<221>  source
<222>  (1)..(70)
<223>  100-23

<400>  28

Val Asn Tyr Val Asp Gln Asp Asn Asn Asn Ala Gln Ile Ala Thr Ser 
1               5                   10                  15      


Gly Asn Leu Thr Gly Lys Pro Gly Ser Val Ile Asn Tyr Ser Thr Ala 
            20                  25                  30          


Asp Gln Ile Lys Gln Leu Glu Ala Gln Gly Tyr Val Leu Val Ser Asp 
        35                  40                  45              


Gly Phe Pro Ala Gly Ala Val Phe Asp Asn Asp Asp Asn Thr Thr Gln 
    50                  55                  60                  


Thr Tyr Thr Val Val Leu 
65                  70  


<210>  29
<211>  66
<212>  PRT
<213>  Leuconostoc argentinum


<220>
<221>  source
<222>  (1)..(66)
<223>  KCTC 3773

<400>  29

Val Ser Tyr Val Asp Asp Thr Thr Gly Lys Thr Leu Lys Thr Asp Ser 
1               5                   10                  15      


Ile Ser Gly Thr Thr Gly Ser Lys Ser Ser Tyr Ser Thr Ser Gly Asn 
            20                  25                  30          


Ile Ala Asp Tyr Lys Lys His Gly Tyr Glu Leu Val Thr Asp Gly Tyr 
        35                  40                  45              


Pro Ala Asp Leu Thr Phe Asp Asn Asp Asp Lys Thr Asp Gln Asn Phe 
    50                  55                  60                  


Thr Val 
65      


<210>  30
<211>  66
<212>  PRT
<213>  Lactobacillus coryniformis


<220>
<221>  source
<222>  (1)..(66)
<223>  subspecies torquens KCTC 3535

<400>  30

Val Ser Tyr Val Asp Asp Thr Thr Gly Lys Thr Leu Lys Thr Asp Ser 
1               5                   10                  15      


Ile Ser Gly Thr Thr Gly Ser Lys Ser Ser Tyr Ser Thr Ser Gly Asn 
            20                  25                  30          


Ile Ala Asp Tyr Lys Lys Gln Gly Tyr Glu Leu Val Thr Asp Gly Tyr 
        35                  40                  45              


Pro Ala Asp Leu Thr Phe Asp Asn Asp Asp Thr Thr Asp Gln Asn Phe 
    50                  55                  60                  


Thr Val 
65      


<210>  31
<211>  70
<212>  PRT
<213>  Lactobacillus reuteri


<220>
<221>  source
<222>  (1)..(70)
<223>  100-23

<400>  31

Val Asn Tyr Val Asp Gln Asp Asn Asn Asn Ala Gln Ile Ala Thr Ser 
1               5                   10                  15      


Gly Asn Leu Thr Gly Lys Pro Gly Ser Val Ile Asn Tyr Ser Thr Ala 
            20                  25                  30          


Asp Gln Ile Lys Gln Leu Glu Asp Gln Gly Tyr Val Leu Val Ser Asp 
        35                  40                  45              


Gly Phe Pro Ala Gly Ala Val Phe Asp Asn Asp Asp Asn Thr Thr Gln 
    50                  55                  60                  


Thr Tyr Thr Val Val Leu 
65                  70  


<210>  32
<211>  70
<212>  PRT
<213>  Streptococcus salivarius


<220>
<221>  source
<222>  (1)..(70)
<223>  CCHSS3

<400>  32

Ala Ser Val Thr Tyr Arg Asp Glu Thr Ser Gly Ser Ile Leu Glu Thr 
1               5                   10                  15      


Val Ala Leu Ala Gly Lys Ser Gly Glu Ala Ile Asn Tyr Ser Thr Ala 
            20                  25                  30          


Glu Arg Ile Lys His Tyr Gln Asp Leu Gly Tyr Ala Leu Val Thr Asp 
        35                  40                  45              


Gly Tyr Pro Ala Gly Ala Ser Phe Asp Leu Asp Ser Thr Val Asp Gln 
    50                  55                  60                  


Ala Trp Thr Val Ser Phe 
65                  70  


<210>  33
<211>  66
<212>  PRT
<213>  Leuconostoc citreum


<220>
<221>  source
<222>  (1)..(66)
<223>  KM20

<400>  33

Val Ser Tyr Val Asp Asp Thr Thr Gly Lys Thr Leu Lys Thr Asp Ser 
1               5                   10                  15      


Ile Ser Gly Thr Thr Gly Ser Lys Ser Ser Tyr Ser Thr Ser Gly Asn 
            20                  25                  30          


Ile Ala Asp Tyr Lys Lys Gln Gly Tyr Glu Leu Val Thr Asp Gly Tyr 
        35                  40                  45              


Pro Ala Asp Leu Thr Phe Asp Asn Asn Asp Thr Thr Asp Gln Asn Phe 
    50                  55                  60                  


Thr Val 
65      


<210>  34
<211>  64
<212>  PRT
<213>  Lactobacillus gasseri


<220>
<221>  source
<222>  (1)..(64)
<223>  202-4

<400>  34

Asp Gly Ala Asn Lys Gln Leu Ala Thr Ser Gly Asp Leu Thr Gly Lys 
1               5                   10                  15      


Ser Gly Ser Glu Ile Ser Tyr Ser Thr Ala Asp Gln Ile Lys Lys Leu 
            20                  25                  30          


Ile Asn Gln Gly Tyr Val Leu Lys Asn Asp Gly Phe Pro Ala Gly Ala 
        35                  40                  45              


Val Phe Asp Asn Asp Asp Ser Lys Asn Gln Val Phe Tyr Val Asp Phe 
    50                  55                  60                  


<210>  35
<211>  64
<212>  PRT
<213>  Lactobacillus gasseri


<220>
<221>  source
<222>  (1)..(64)
<223>  224-1

<400>  35

Asp Gly Ala Asn Lys Gln Leu Ala Thr Ser Gly Asp Leu Thr Gly Lys 
1               5                   10                  15      


Ser Gly Ser Glu Ile Ser Tyr Ser Thr Ala Asp Gln Ile Lys Lys Leu 
            20                  25                  30          


Ile Asn Gln Gly Tyr Val Leu Lys Asn Asp Gly Phe Pro Ala Gly Ala 
        35                  40                  45              


Val Phe Asp Asn Asp Asp Ser Lys Asn Gln Val Phe Tyr Val Asp Phe 
    50                  55                  60                  


<210>  36
<211>  64
<212>  PRT
<213>  Lactobacillus gasseri


<220>
<221>  source
<222>  (1)..(64)
<223>  ATCC 33323

<400>  36

Asp Gly Ala Asn Lys Gln Leu Ala Thr Ser Gly Asp Leu Thr Gly Lys 
1               5                   10                  15      


Ser Gly Ser Glu Ile Ser Tyr Ser Thr Ala Asp Gln Ile Lys Lys Leu 
            20                  25                  30          


Ile Asn Gln Gly Tyr Val Leu Lys Asn Asp Gly Phe Pro Ala Gly Ala 
        35                  40                  45              


Val Phe Asp Asn Asp Asp Ser Lys Asn Gln Val Phe Tyr Val Asp Phe 
    50                  55                  60                  


<210>  37
<211>  64
<212>  PRT
<213>  Lactobacillus gasseri


<220>
<221>  source
<222>  (1)..(64)
<223>  MV-22

<400>  37

Asp Gly Ala Asn Lys Gln Leu Ala Thr Ser Gly Asp Leu Thr Gly Lys 
1               5                   10                  15      


Ser Gly Ser Glu Ile Ser Tyr Ser Thr Ala Asp Gln Ile Lys Lys Leu 
            20                  25                  30          


Ile Asn Gln Gly Tyr Val Leu Lys Asn Asp Gly Phe Pro Ala Gly Ala 
        35                  40                  45              


Val Phe Asp Asn Asp Asp Ser Lys Asn Gln Val Phe Tyr Val Asp Phe 
    50                  55                  60                  


<210>  38
<211>  71
<212>  PRT
<213>  Lactobacillus delbrueckii


<220>
<221>  source
<222>  (1)..(71)
<223>  subspecies bulgaricus ND02

<400>  38

Ala Lys Val Ala Tyr Ile Asp Asp Lys Thr Gly Lys Thr Leu Lys Thr 
1               5                   10                  15      


Asp Ser Leu Thr Gly Val Thr Asn Ala Lys Ser Gly Tyr Thr Thr Ala 
            20                  25                  30          


Asp Ser Ile Lys Thr Tyr Gln Ala Leu Gly Tyr Lys Leu Val Ser Asp 
        35                  40                  45              


Asp Thr Lys Gly Ala Glu Ile Val Phe Asp Asn Glu Asp Gly Lys Asp 
    50                  55                  60                  


Gln Ser Tyr Thr Val His Phe 
65                  70      


<210>  39
<211>  70
<212>  PRT
<213>  Lactobacillus crispatus


<220>
<221>  source
<222>  (1)..(70)
<223>  125-2-CHN

<400>  39

Val Asn Tyr Ile Asp Ser Asp Glu Gly Asn Lys Val Ile Thr Thr Ser 
1               5                   10                  15      


Gly Asn Leu Ser Gly Lys Ala Gly Ser Thr Ile Asp Tyr Ser Thr Lys 
            20                  25                  30          


Ser Thr Ile Ala Asp Leu Glu Asn Lys Gly Tyr Val Leu Val Asn Asp 
        35                  40                  45              


Gly Phe Pro Ala Gly Ala Lys Phe Asp Ser Asp Asp Asn Thr Thr Gln 
    50                  55                  60                  


Ile Phe Thr Val Val Leu 
65                  70  


<210>  40
<211>  70
<212>  PRT
<213>  Unknown

<220>
<223>  S. species C150


<220>
<221>  source
<222>  (1)..(70)
<223>  S. species C150

<400>  40

Ala Ser Val Thr Tyr Arg Asp Glu Thr Gly Gly Ser Thr Leu Glu Thr 
1               5                   10                  15      


Val Ser Leu Ala Gly Lys Ser Gly Glu Ala Val Gly Tyr Ser Thr Ala 
            20                  25                  30          


Glu Arg Ile Lys His Tyr Gln Asp Leu Gly Tyr Val Leu Val Thr Asp 
        35                  40                  45              


Gly Tyr Pro Ala Gly Thr Thr Phe Asp Leu Asp Ser Thr Val Asp Gln 
    50                  55                  60                  


Ala Trp Thr Val Ser Phe 
65                  70  


<210>  41
<211>  70
<212>  PRT
<213>  Streptococcus salivarius


<220>
<221>  source
<222>  (1)..(70)
<223>  SK126

<400>  41

Ala Ser Val Thr Tyr Arg Asp Glu Thr Ser Gly Ser Thr Leu Glu Thr 
1               5                   10                  15      


Val Ala Leu Ala Gly Lys Ser Gly Glu Ala Val Asn Tyr Ser Thr Ala 
            20                  25                  30          


Asp Arg Ile Lys His Tyr Gln Asp Leu Gly Tyr Val Leu Val Thr Asp 
        35                  40                  45              


Gly Tyr Pro Ala Gly Ala Thr Phe Asp Leu Asp Ser Thr Val Asp Gln 
    50                  55                  60                  


Ala Trp Thr Val Ser Phe 
65                  70  


<210>  42
<211>  70
<212>  PRT
<213>  Streptococcus mitis


<220>
<221>  source
<222>  (1)..(70)
<223>  NCTC 12261

<400>  42

Ile Arg Tyr Val Ser Thr Asn Gly Asn Gln Val Leu Lys Thr Asp Glu 
1               5                   10                  15      


Val Thr Gly Lys Ser Gly Glu Ala Ile Ala Tyr Ser Thr Thr Ser Gln 
            20                  25                  30          


Ile Asn Glu Phe Lys Lys Gln Gly Tyr Lys Leu Val Ser Asp Glu Phe 
        35                  40                  45              


Thr Ala Gly Gly Ala Lys Val Tyr Asp Tyr Asp Thr Ala Arg Asp Gln 
    50                  55                  60                  


Val Tyr Thr Val Thr Leu 
65                  70  


<210>  43
<211>  69
<212>  PRT
<213>  Weissella cibaria


<220>
<221>  source
<222>  (1)..(69)
<223>  KACC 11862

<400>  43

Ile Ala Tyr Ile Asp Lys Thr Thr Gly Lys Gln Leu Ala Leu Asp Pro 
1               5                   10                  15      


Ile Thr Gly His Ser Asp Glu Ser Ser Thr Tyr Thr Thr Ala Asp Lys 
            20                  25                  30          


Ile Ala Ala Tyr Glu Ala Ala Gly Tyr Val Leu Val Ser Asp Gly Tyr 
        35                  40                  45              


Pro Gly Ala Asn Phe Thr Phe Asp Arg Glu Asp Asp Tyr Asp Gln Thr 
    50                  55                  60                  


Tyr Glu Val Ile Leu 
65                  


<210>  44
<211>  68
<212>  PRT
<213>  Streptococcus salivarius


<220>
<221>  source
<222>  (1)..(68)
<223>  CCHSS3

<400>  44

Ile Thr Tyr Ile Asp Glu Thr Thr Gly Ala Tyr Leu Val Ser Asp Gln 
1               5                   10                  15      


Leu Thr Gly Glu Leu Gly Glu Ala Ile Glu Tyr Gly Thr Ala Thr Arg 
            20                  25                  30          


Ile Lys Thr Phe Lys Asp Met Gly Tyr Glu Leu Ile Gln Asp Glu Phe 
        35                  40                  45              


Pro Lys Asp Ala Ile Phe Asp Asp Lys Asp Ile Asp Asp Gln Glu Trp 
    50                  55                  60                  


Phe Val Leu Leu 
65              


<210>  45
<211>  67
<212>  PRT
<213>  Lactobacillus johnsonii


<220>
<221>  source
<222>  (1)..(67)
<223>  ATCC 33200

<400>  45

Val Thr Tyr Val Asp Asp Lys Thr Gly Lys Thr Leu Lys Val Asp Asn 
1               5                   10                  15      


Leu Asn Gly Val Thr Ser Ala Lys Ser Gly Tyr Thr Thr Lys Ala Ala 
            20                  25                  30          


Ile Asp Thr Tyr Thr Gly Leu Gly Tyr Thr Leu Val Ser Asp Asp Thr 
        35                  40                  45              


Asn Gly Asn Glu Val Val Phe Asp Asn Asp Asp Ser Asn Asp Gln Ala 
    50                  55                  60                  


Phe Thr Val 
65          


<210>  46
<211>  70
<212>  PRT
<213>  Lactobacillus acidophilus


<220>
<221>  source
<222>  (1)..(70)
<223>  NCFM

<400>  46

Val Asn Tyr Ile Asp Ala Asp Glu Gly Asn Lys Val Ile Ile Ser Ser 
1               5                   10                  15      


Gly Asn Leu Ile Gly Lys Ala Gly Asp Lys Val Asp Tyr Asn Thr Ser 
            20                  25                  30          


Asp Thr Ile Lys Asn Leu Glu Asn Lys Gly Tyr Val Leu Val His Asn 
        35                  40                  45              


Gly Phe Pro Asp Gly Val Thr Phe Asp Asn Asp Asp Ser Thr Ile Gln 
    50                  55                  60                  


Thr Tyr Thr Val Ile Leu 
65                  70  


<210>  47
<211>  70
<212>  PRT
<213>  Lactobacillus acidophilus


<220>
<221>  source
<222>  (1)..(70)
<223>  ATCC 4796

<400>  47

Val Asn Tyr Ile Asp Ala Asp Glu Gly Asn Lys Val Ile Ile Ser Ser 
1               5                   10                  15      


Gly Asn Leu Ile Gly Lys Ala Gly Asp Lys Val Asp Tyr Asn Thr Ser 
            20                  25                  30          


Asp Thr Ile Lys Asn Leu Glu Asn Lys Gly Tyr Val Leu Val His Asn 
        35                  40                  45              


Gly Phe Pro Asp Gly Val Thr Phe Asp Asn Asp Asp Ser Thr Ile Gln 
    50                  55                  60                  


Thr Tyr Thr Val Ile Leu 
65                  70  


<210>  48
<211>  68
<212>  PRT
<213>  Streptococcus salivarius


<220>
<221>  source
<222>  (1)..(68)
<223>  SK126

<400>  48

Ile Thr Tyr Ile Asp Glu Thr Thr Gly Ala Tyr Leu Val Ser Asp Gln 
1               5                   10                  15      


Leu Thr Gly Glu Leu Gly Glu Ala Ile Glu Tyr Gly Thr Ala Thr Arg 
            20                  25                  30          


Ile Lys Thr Phe Lys Asp Met Gly Tyr Asp Leu Ile Gln Asp Glu Phe 
        35                  40                  45              


Pro Lys Asp Ala Ile Phe Asp Asp Lys Asp Ile Asp Asp Gln Glu Trp 
    50                  55                  60                  


Phe Val Leu Leu 
65              


<210>  49
<211>  66
<212>  PRT
<213>  Lactobacillus delbrueckii


<220>
<221>  source
<222>  (1)..(66)
<223>  subspecies bulgaricus ND02

<400>  49

Val Ser Tyr Val Asp Asp Thr Thr Gly Lys Thr Leu Lys Thr Asp Ser 
1               5                   10                  15      


Ile Ser Gly Ile Thr Gly Ser Lys Ser Ser Tyr Ser Thr Ser Gly Ser 
            20                  25                  30          


Ile Ala Asp Tyr Lys Lys Gln Gly Tyr Glu Leu Val Thr Asp Gly Tyr 
        35                  40                  45              


Pro Ala Asp Leu Thr Phe Asp Asn Asp Asp Thr Thr Asp Gln Asn Phe 
    50                  55                  60                  


Thr Val 
65      


<210>  50
<211>  66
<212>  PRT
<213>  Lactobacillus fermentum


<220>
<221>  source
<222>  (1)..(66)
<223>  28-3-CHN

<400>  50

Val Ser Tyr Val Asp Asp Thr Thr Gly Lys Thr Leu Lys Thr Asp Ser 
1               5                   10                  15      


Ile Ser Gly Thr Thr Gly Ser Lys Ser Ser Tyr Ser Thr Ser Gly Ser 
            20                  25                  30          


Ile Ala Asp Tyr Lys Lys Gln Gly Tyr Glu Leu Val Thr Asp Gly Tyr 
        35                  40                  45              


Pro Ala Asp Leu Thr Phe Asp Asn Asp Asp Thr Thr Asp Gln Asn Phe 
    50                  55                  60                  


Thr Val 
65      


<210>  51
<211>  66
<212>  PRT
<213>  Lactobacillus fermentum


<220>
<221>  source
<222>  (1)..(66)
<223>  IFO 3956

<400>  51

Val Ser Tyr Val Asp Asp Thr Thr Gly Lys Thr Leu Lys Thr Asp Ser 
1               5                   10                  15      


Ile Ser Gly Thr Thr Gly Ser Lys Ser Ser Tyr Ser Thr Ser Gly Ser 
            20                  25                  30          


Ile Ala Asp Tyr Lys Lys Gln Gly Tyr Glu Leu Val Thr Asp Gly Tyr 
        35                  40                  45              


Pro Ala Asp Leu Thr Phe Asp Asn Asp Asp Thr Lys Asp Gln Asn Phe 
    50                  55                  60                  


Thr Val 
65      


<210>  52
<211>  68
<212>  PRT
<213>  Unknown

<220>
<223>  S. species C150


<220>
<221>  source
<222>  (1)..(68)
<223>  S. species C150

<400>  52

Val Thr Tyr Val Asp Gly Thr Thr Arg Lys Lys Leu Glu Val Val Asp 
1               5                   10                  15      


Leu Leu Gly Lys Ser Gly Glu Val Ile Asp Tyr Ser Thr Ile Glu Arg 
            20                  25                  30          


Ile Lys Tyr Tyr Ser Asp Arg Gly Tyr Thr Leu Leu Ala Asp Gly Phe 
        35                  40                  45              


Thr Asn Gly Val Ile Phe Asp Gly Asp Ser His Val Asp Gln Asn Phe 
    50                  55                  60                  


Met Val Thr Leu 
65              


<210>  53
<211>  66
<212>  PRT
<213>  Lactobacillus fermentum


<220>
<221>  source
<222>  (1)..(66)
<223>  28-3-CHN

<400>  53

Val Ser Tyr Val Asp Asp Thr Thr Arg Lys Thr Leu Lys Thr Asp Ser 
1               5                   10                  15      


Ile Ser Gly Thr Thr Gly Ser Lys Ser Ser Tyr Ser Thr Ser Gly Ser 
            20                  25                  30          


Ile Ala Asp Tyr Lys Lys Gln Gly Tyr Glu Leu Val Thr Asp Gly Tyr 
        35                  40                  45              


Pro Ala Asp Leu Met Phe Asp Asn Asp Asp Thr Thr Asp Gln Asn Phe 
    50                  55                  60                  


Thr Val 
65      


<210>  54
<211>  64
<212>  PRT
<213>  Lactobacillus gasseri


<220>
<221>  source
<222>  (1)..(64)
<223>  JV-V03

<400>  54

Ile Ile Tyr Val Asp Glu Thr Thr Gly Lys Ala Leu Glu Thr Ala Thr 
1               5                   10                  15      


Val Asp Gly Lys Tyr Asn Glu Ser Ile Asn Tyr Ser Thr Ala Asp Lys 
            20                  25                  30          


Ile Lys Tyr Tyr Glu Ser Leu Gly Tyr Glu Leu Val Lys Asp Gly Tyr 
        35                  40                  45              


Thr Ala Gly Lys Phe Gly Glu Thr Thr Lys Thr Phe Tyr Val Ile Phe 
    50                  55                  60                  


<210>  55
<211>  52
<212>  PRT
<213>  Lactobacillus gasseri


<220>
<221>  source
<222>  (1)..(52)
<223>  202-4

<400>  55

Ile Val Tyr Val Asp Glu Thr Thr Gly Lys Glu Leu Glu Arg Ala Thr 
1               5                   10                  15      


Val Asp Gly Lys Tyr Asn Glu Thr Ile Asn Tyr Ser Thr Ala Asp Lys 
            20                  25                  30          


Ile Lys Tyr Tyr Glu Ser Leu Gly Tyr Glu Leu Val Lys Asp Gly Tyr 
        35                  40                  45              


Thr Gly Gly Glu 
    50          


<210>  56
<211>  68
<212>  PRT
<213>  Lactobacillus gasseri


<220>
<221>  source
<222>  (1)..(68)
<223>  MV-22

<400>  56

Leu Asp Asn Glu Gly Gln Gln Ile Thr Ser Ser Gly Pro Leu Ile Gly 
1               5                   10                  15      


Lys Pro Asn Glu Asn Ile Thr Asp Leu Tyr Ser Thr Ser Ile Pro Leu 
            20                  25                  30          


Ala Gly Leu Glu Lys Ala Gly Tyr His Val Ile Phe Asn Asn Phe Asp 
        35                  40                  45              


Gly Asn Asn Lys Ile Gln Lys Phe Asp Gly Asn Asp Leu Thr Thr Gln 
    50                  55                  60                  


Val Phe Thr Val 
65              


<210>  57
<211>  68
<212>  PRT
<213>  L. gasseri 202-4


<220>
<221>  source
<222>  (1)..(68)
<223>  202-4

<400>  57

Leu Asp Asn Glu Gly Gln Gln Ile Thr Ser Ser Gly Pro Leu Ile Gly 
1               5                   10                  15      


Lys Pro Asn Glu Asn Ile Thr Asp Leu Tyr Ser Thr Ser Ile Pro Leu 
            20                  25                  30          


Ala Gly Leu Glu Lys Ala Gly Tyr His Val Ile Phe Asn Asn Phe Asp 
        35                  40                  45              


Gly Asn Asn Lys Ile Gln Lys Phe Asp Gly Asn Asp Leu Thr Thr Gln 
    50                  55                  60                  


Val Phe Thr Val 
65              


<210>  58
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUB40-1 probe sequence

<400>  58

Thr Ala Glu Gly Ile Lys Lys Phe Glu Gly Asp Gly Tyr Glu Leu Phe 
1               5                   10                  15      


Lys Asp Asn Phe Pro Ala Gly Glu Lys Phe Asp Asn Asp Asp Thr Asn 
            20                  25                  30          


Asp Gln Phe Tyr Thr Val Ile Phe 
        35                  40  


<210>  59
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUB40-2 probe sequence

<400>  59

Gly Tyr Thr Asp Glu Thr Ile Pro Tyr Ser Thr Ala Glu Gly Ile Lys 
1               5                   10                  15      


Lys Phe Glu Gly Asp Gly Tyr Glu Leu Phe Lys Asp Asn Phe Pro Ala 
            20                  25                  30          


Gly Glu Lys Phe Asp Asn Asp Asp 
        35                  40  


<210>  60
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUB40-3 probe sequence

<400>  60

Asp Gln Met Leu Arg Gln Asp Asp Leu Asp Gly Tyr Thr Asp Glu Thr 
1               5                   10                  15      


Ile Pro Tyr Ser Thr Ala Glu Gly Ile Lys Lys Phe Glu Gly Asp Gly 
            20                  25                  30          


Tyr Glu Leu Phe Lys Asp Asn Phe 
        35                  40  


<210>  61
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUB40-4 probe sequence

<400>  61

Val His Val Gln Tyr Ile Asp Gly Glu Thr Asp Gln Met Leu Arg Gln 
1               5                   10                  15      


Asp Asp Leu Asp Gly Tyr Thr Asp Glu Thr Ile Pro Tyr Ser Thr Ala 
            20                  25                  30          


Glu Gly Ile Lys Lys Phe Glu Gly 
        35                  40  


<210>  62
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUB40-1 with cystein residue at N-terminal extremity

<400>  62

Cys Thr Ala Glu Gly Ile Lys Lys Phe Glu Gly Asp Gly Tyr Glu Leu 
1               5                   10                  15      


Phe Lys Asp Asn Phe Pro Ala Gly Glu Lys Phe Asp Asn Asp Asp Thr 
            20                  25                  30          


Asn Asp Gln Phe Tyr Thr Val Ile Phe 
        35                  40      


<210>  63
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   CGYTDETIPYSTAEGIKKFEGDGYELFKDNFPAGEKFDNDD

<400>  63

Cys Gly Tyr Thr Asp Glu Thr Ile Pro Tyr Ser Thr Ala Glu Gly Ile 
1               5                   10                  15      


Lys Lys Phe Glu Gly Asp Gly Tyr Glu Leu Phe Lys Asp Asn Phe Pro 
            20                  25                  30          


Ala Gly Glu Lys Phe Asp Asn Asp Asp 
        35                  40      


<210>  64
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUB40-3 with cystein residue at N-terminal extremity

<400>  64

Cys Asp Gln Met Leu Arg Gln Asp Asp Leu Asp Gly Tyr Thr Asp Glu 
1               5                   10                  15      


Thr Ile Pro Tyr Ser Thr Ala Glu Gly Ile Lys Lys Phe Glu Gly Asp 
            20                  25                  30          


Gly Tyr Glu Leu Phe Lys Asp Asn Phe 
        35                  40      


<210>  65
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUB40-4 with cystein residue at N-terminal extremity

<400>  65

Cys Val His Val Gln Tyr Ile Asp Gly Glu Thr Asp Gln Met Leu Arg 
1               5                   10                  15      


Gln Asp Asp Leu Asp Gly Tyr Thr Asp Glu Thr Ile Pro Tyr Ser Thr 
            20                  25                  30          


Ala Glu Gly Ile Lys Lys Phe Glu Gly 
        35                  40      


<210>  66
<211>  264
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gene sequence corresponding to MUB70


<220>
<221>  misc_feature
<222>  (16)..(21)
<223>  EcorV/SmaI restriction site

<220>
<221>  misc_feature
<222>  (247)..(252)
<223>  EcorV/SmaI restriction site

<400>  66
tcgcgaggat ccggtgatat cgttcacgtt caatacattg atggtgaaac tgaccagatg       60

ctgcgtcagg atgatttgga cggctacacg gatgaaacga ttccttacag cacggctgaa      120

ggcatcaaga agtttgaagg cgacggttat gaactgttca aggacaactt cccagctggt      180

gagaagttcg ataacgatga caccaacgat caattctaca cggtaatctt caagcaccat      240

cgtggcccgg gagggcccaa gctt                                             264


<210>  67
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUB40 consensus sequence


<220>
<221>  Source
<222>  (1)..(7)
<223>  Consensus sequence

<220>
<221>  DOMAIN
<222>  (3)..(3)
<223>  Xaa represents a fragment of 12 to 16 of any amino-acid

<220>
<221>  DOMAIN
<222>  (4)..(4)
<223>  Phe can be  replaced by Tyr

<220>
<221>  DOMAIN
<222>  (6)..(6)
<223>  Xaa represents a fragment of 5 to 9 of any amino-acid

<400>  67

Gly Tyr Xaa Phe Asp Xaa Gln 
1               5           


<210>  68
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUB40 consensus sequence


<220>
<221>  source
<222>  (1)..(15)
<223>  MUB40 Consensus sequence

<220>
<221>  DOMAIN
<222>  (3)..(3)
<223>  Xaa can be any amino acid

<220>
<221>  DOMAIN
<222>  (5)..(5)
<223>  Xaa represents a fragment of 10 to 14 of any amino acid

<220>
<221>  DOMAIN
<222>  (6)..(6)
<223>  Phe can be replaced by Tyr

<220>
<221>  DOMAIN
<222>  (8)..(8)
<223>  Xaa can be any amino acid

<220>
<221>  DOMAIN
<222>  (10)..(10)
<223>  Xaa represents a fragment of 2 to 6 of any amino acid

<220>
<221>  DOMAIN
<222>  (12)..(12)
<223>  Xaa can be any amino acid

<220>
<221>  DOMAIN
<222>  (13)..(13)
<223>  Tyr can be replaced by Phe or Trp

<220>
<221>  DOMAIN
<222>  (14)..(14)
<223>  Thr can be replaced by Tyr or Glu

<400>  68

Gly Tyr Xaa Leu Xaa Phe Asp Xaa Asp Xaa Gln Xaa Tyr Thr Val 
1               5                   10                  15  


<210>  69
<211>  41
<212>  PRT
<213>  Lactobacillus reuteri


<220>
<221>  source
<222>  (1)..(41)
<223>  LPXTG

<400>  69

Ser Thr Ala Asp Gln Ile Lys Gln Leu Glu Ala Gln Gly Tyr Val Leu 
1               5                   10                  15      


Val Ser Asp Gly Phe Pro Ala Gly Ala Val Phe Asp Asn Asp Asp Asn 
            20                  25                  30          


Thr Thr Gln Thr Tyr Thr Val Val Leu 
        35                  40      


<210>  70
<211>  41
<212>  PRT
<213>  Lactobacillus fermentum

<400>  70

Ser Thr Ala Ala Thr Ile Lys Gln Leu Glu Asp Gln Gly Tyr Val Leu 
1               5                   10                  15      


Val Ser Asn Gly Phe Pro Ala Gly Ala Val Phe Asp Asn Asp Asp Asn 
            20                  25                  30          


Thr Thr Gln Thr Tyr Thr Val Val Leu 
        35                  40      


<210>  71
<211>  41
<212>  PRT
<213>  Lactobacillus acidophilus

<400>  71

Ser Thr Ala Asp Thr Ile Lys Asp Leu Glu Asn Lys Gly Tyr Val Leu 
1               5                   10                  15      


Val Asn Asp Gly Phe Pro Ala Gly Ala Lys Tyr Asp Ser Asp Asp Asn 
            20                  25                  30          


Thr Thr Gln Ile Tyr Thr Val Val Leu 
        35                  40      


<210>  72
<211>  41
<212>  PRT
<213>  Lactobacillus crispatus

<400>  72

Ser Thr Lys Ser Thr Ile Ala Asp Leu Glu Asn Lys Gly Tyr Val Leu 
1               5                   10                  15      


Val Asn Asp Gly Phe Pro Ala Gly Ala Lys Phe Asp Ser Asp Asp Asn 
            20                  25                  30          


Thr Thr Gln Ile Phe Thr Val Val Leu 
        35                  40      


<210>  73
<211>  41
<212>  PRT
<213>  Lactobacillus johnsonii

<400>  73

Ser Thr Ala Ser Thr Ile Glu Glu Leu Glu Asn Lys Gly Tyr Val Leu 
1               5                   10                  15      


Val Ser Asp Gly Phe Pro Ala Gly Ala Thr Phe Asp Asn Asp Asp Asn 
            20                  25                  30          


Thr Thr Gln Ile Tyr Thr Val Val Leu 
        35                  40      


<210>  74
<211>  41
<212>  PRT
<213>  Unknown

<220>
<223>  Lactobacillus hominis

<400>  74

Ser Thr Gln Ser Thr Ile Thr Ser Leu Glu Asn Gln Gly Tyr Glu Leu 
1               5                   10                  15      


Val His Asp Gly Phe Pro Thr Gly Ala Thr Tyr Asp Asn Asp Asp Asn 
            20                  25                  30          


Thr Thr Gln Thr Tyr Thr Val Val Leu 
        35                  40      


<210>  75
<211>  41
<212>  PRT
<213>  Lactobacillus gasseri

<400>  75

Ser Thr Ala Asp Gln Ile Lys Lys Leu Ile Asn Gln Gly Tyr Val Leu 
1               5                   10                  15      


Lys Asn Asp Gly Phe Pro Ala Gly Ala Val Phe Asp Asn Asp Asp Ser 
            20                  25                  30          


Lys Asn Gln Val Phe Tyr Val Asp Phe 
        35                  40      


<210>  76
<211>  41
<212>  PRT
<213>  Unknown

<220>
<223>  Lactobacillus mucosae

<400>  76

Ser Thr Ala Glu Gly Ile Lys Lys Phe Glu Gly Asp Gly Tyr Glu Leu 
1               5                   10                  15      


Phe Lys Asp Asn Phe Pro Ala Gly Glu Lys Phe Asp Asn Asp Asp Ala 
            20                  25                  30          


Asn Asp Gln Thr Tyr Thr Val Ile Phe 
        35                  40      


<210>  77
<211>  41
<212>  PRT
<213>  Unknown

<220>
<223>  Streptococcus sp. C150

<400>  77

Ser Thr Ala Glu Arg Ile Lys His Tyr Gln Asp Leu Gly Tyr Val Leu 
1               5                   10                  15      


Val Thr Asp Gly Tyr Pro Ala Gly Thr Thr Phe Asp Leu Asp Ser Thr 
            20                  25                  30          


Val Asp Gln Ala Trp Thr Val Ser Phe 
        35                  40      


<210>  78
<211>  40
<212>  PRT
<213>  Streptococcus salivarius

<400>  78

Thr Ala Glu Arg Ile Lys His Tyr Gln Asp Leu Gly Tyr Ala Leu Val 
1               5                   10                  15      


Thr Asp Gly Tyr Pro Ala Gly Ala Ser Phe Asp Leu Asp Ser Thr Val 
            20                  25                  30          


Asp Gln Ala Trp Thr Val Ser Phe 
        35                  40  


<210>  79
<211>  38
<212>  PRT
<213>  Unknown

<220>
<223>  Streptococcus garvieae

<400>  79

Thr Ser Gly Ser Ile Ala Asp Tyr Lys Lys His Gly Tyr Glu Leu Val 
1               5                   10                  15      


Thr Asp Gly Tyr Pro Ala Asp Leu Thr Phe Asp Asn Asp Asp Thr Thr 
            20                  25                  30          


Asp Gln Asn Phe Thr Val 
        35              


<210>  80
<211>  39
<212>  PRT
<213>  Leuconostoc argentinum

<400>  80

Ser Thr Ser Gly Asn Ile Ala Asp Tyr Lys Lys His Gly Tyr Glu Leu 
1               5                   10                  15      


Val Thr Asp Gly Tyr Pro Ala Asp Leu Thr Phe Asp Asn Asp Asp Lys 
            20                  25                  30          


Thr Asp Gln Asn Phe Thr Val 
        35                  


<210>  81
<211>  38
<212>  PRT
<213>  Lactobacillus coryniformis

<400>  81

Thr Ser Gly Asn Ile Ala Asp Tyr Lys Lys Gln Gly Tyr Glu Leu Val 
1               5                   10                  15      


Thr Asp Gly Tyr Pro Ala Asp Leu Thr Phe Asp Asn Asp Asp Thr Thr 
            20                  25                  30          


Asp Gln Asn Phe Thr Val 
        35              


<210>  82
<211>  43
<212>  PRT
<213>  Unknown

<220>
<223>  Streptococcus cristatus

<400>  82

Ser Thr Ala Ser Arg Ile Glu Gln Leu Lys Gln Ala Gly Tyr Thr Leu 
1               5                   10                  15      


Val Ser Asp Gly Phe Thr Gln Pro Asn Gly Gln Lys Phe Asp Asn Asp 
            20                  25                  30          


Lys Thr Lys Asp Gln Thr Trp Thr Val Val Val 
        35                  40              


<210>  83
<211>  38
<212>  PRT
<213>  Weissella confusa

<400>  83

Thr Ala Asp Arg Ile Lys Ala Tyr Glu Ala Gln Gly Tyr Thr Leu Val 
1               5                   10                  15      


Ser Asp Asp Phe Pro Ala Asp Phe Gln Phe Asp Arg Asp Asp Ala Thr 
            20                  25                  30          


Glu Gln Lys Phe Glu Val 
        35              


