                         SEQUENCE LISTING

<110>  INSERM (Institut National de la Sant et de la Recherche 
       Mdicale)
 
<120>  NOVEL MUTATED TISSUE PLASMINOGEN ACTIVATORS AND USES THEREOF

<130>  BEP110655 EP

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg 
            20                  25                  30          


Gly Ala Arg Ser Tyr Gln Val Ile Cys Arg Asp Glu Lys Thr Gln Met 
        35                  40                  45              


Ile Tyr Gln Gln His Gln Ser Trp Leu Arg Pro Val Leu Arg Ser Asn 
    50                  55                  60                  


Arg Val Glu Tyr Cys Trp Cys Asn Ser Gly Arg Ala Gln Cys His Ser 
65                  70                  75                  80  


Val Pro Val Lys Ser Cys Ser Glu Pro Arg Cys Phe Asn Gly Gly Thr 
                85                  90                  95      


Cys Gln Gln Ala Leu Tyr Phe Ser Asp Phe Val Cys Gln Cys Pro Glu 
            100                 105                 110         


Gly Phe Ala Gly Lys Cys Cys Glu Ile Asp Thr Arg Ala Thr Cys Tyr 
        115                 120                 125             


Glu Asp Gln Gly Ile Ser Tyr Arg Gly Thr Trp Ser Thr Ala Glu Ser 
    130                 135                 140                 


Gly Ala Glu Cys Thr Asn Trp Asn Ser Ser Ala Leu Ala Gln Lys Pro 
145                 150                 155                 160 


Tyr Ser Gly Arg Arg Pro Asp Ala Ile Arg Leu Gly Leu Gly Asn His 
                165                 170                 175     


Asn Tyr Cys Arg Asn Pro Asp Arg Asp Ser Lys Pro Trp Cys Tyr Val 
            180                 185                 190         


Phe Lys Ala Gly Lys Tyr Ser Ser Glu Phe Cys Ser Thr Pro Ala Cys 
        195                 200                 205             


Ser Glu Gly Asn Ser Asp Cys Tyr Phe Gly Asn Gly Ser Ala Tyr Arg 
    210                 215                 220                 


Gly Thr His Ser Leu Thr Glu Ser Gly Ala Ser Cys Leu Pro Trp Asn 
225                 230                 235                 240 


Ser Met Ile Leu Ile Gly Lys Val Tyr Thr Ala Gln Asn Pro Ser Ala 
                245                 250                 255     


Gln Ala Leu Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Gly 
            260                 265                 270         


Asp Ala Lys Pro Trp Cys His Val Leu Lys Asn Arg Arg Leu Thr Trp 
        275                 280                 285             


Glu Tyr Cys Asp Val Pro Ser Cys Ser Thr Cys Gly Leu Arg Gln Tyr 
    290                 295                 300                 


Ser Gln Pro Gln Phe Arg Ile Lys Gly Gly Leu Phe Ala Asp Ile Ala 
305                 310                 315                 320 


Ser His Pro Trp Gln Ala Ala Ile Phe Ala Lys His Arg Arg Ser Pro 
                325                 330                 335     


Gly Glu Arg Phe Leu Cys Gly Gly Ile Leu Ile Ser Ser Cys Trp Ile 
            340                 345                 350         


Leu Ser Ala Ala His Cys Phe Gln Glu Arg Phe Pro Pro His His Leu 
        355                 360                 365             


Thr Val Ile Leu Gly Arg Thr Tyr Arg Val Val Pro Gly Glu Glu Glu 
    370                 375                 380                 


Gln Lys Phe Glu Val Glu Lys Tyr Ile Val His Lys Glu Phe Asp Asp 
385                 390                 395                 400 


Asp Thr Tyr Asp Asn Asp Ile Ala Leu Leu Gln Leu Lys Ser Asp Ser 
                405                 410                 415     


Ser Arg Cys Ala Gln Glu Ser Ser Val Val Arg Thr Val Cys Leu Pro 
            420                 425                 430         


Pro Ala Asp Leu Gln Leu Pro Asp Trp Thr Glu Cys Glu Leu Ser Gly 
        435                 440                 445             


Tyr Gly Lys His Glu Ala Leu Ser Pro Phe Tyr Ser Glu Arg Leu Lys 
    450                 455                 460                 


Glu Ala His Val Arg Leu Tyr Pro Ser Ser Arg Cys Thr Ser Gln His 
465                 470                 475                 480 


Leu Leu Asn Arg Thr Val Thr Asp Asn Met Leu Cys Ala Gly Asp Thr 
                485                 490                 495     


Arg Ser Gly Gly Pro Gln Ala Asn Leu His Asp Ala Cys Gln Gly Asp 
            500                 505                 510         


Ser Gly Gly Pro Leu Val Cys Leu Asn Asp Gly Arg Met Thr Leu Val 
        515                 520                 525             


Gly Ile Ile Ser Trp Gly Leu Gly Cys Gly Gln Lys Asp Val Pro Gly 
    530                 535                 540                 


Val Tyr Thr Lys Val Thr Asn Tyr Leu Asp Trp Ile Arg Asp Asn Met 
545                 550                 555                 560 


Arg Pro 
        


<210>  2
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Tyr Gln Val Ile Cys Arg Asp Glu Lys Thr Gln Met Ile Tyr Gln 
1               5                   10                  15      


Gln His Gln Ser Trp Leu Arg Pro Val Leu Arg Ser Asn Arg Val Glu 
            20                  25                  30          


Tyr Cys Trp Cys Asn Ser Gly Arg Ala Gln Cys His Ser Val Pro Val 
        35                  40                  45              


Lys Ser Cys Ser Glu Pro Arg Cys Phe Asn Gly Gly Thr Cys Gln Gln 
    50                  55                  60                  


Ala Leu Tyr Phe Ser Asp Phe Val Cys Gln Cys Pro Glu Gly Phe Ala 
65                  70                  75                  80  


Gly Lys Cys Cys Glu Ile Asp Thr Arg Ala Thr Cys Tyr Glu Asp Gln 
                85                  90                  95      


Gly Ile Ser Tyr Arg Gly Thr Trp Ser Thr Ala Glu Ser Gly Ala Glu 
            100                 105                 110         


Cys Thr Asn Trp Asn Ser Ser Ala Leu Ala Gln Lys Pro Tyr Ser Gly 
        115                 120                 125             


Arg Arg Pro Asp Ala Ile Arg Leu Gly Leu Gly Asn His Asn Tyr Cys 
    130                 135                 140                 


Arg Asn Pro Asp Arg Asp Ser Lys Pro Trp Cys Tyr Val Phe Lys Ala 
145                 150                 155                 160 


Gly Lys Tyr Ser Ser Glu Phe Cys Ser Thr Pro Ala Cys Ser Glu Gly 
                165                 170                 175     


Asn Ser Asp Cys Tyr Phe Gly Asn Gly Ser Ala Tyr Arg Gly Thr His 
            180                 185                 190         


Ser Leu Thr Glu Ser Gly Ala Ser Cys Leu Pro Trp Asn Ser Met Ile 
        195                 200                 205             


Leu Ile Gly Lys Val Tyr Thr Ala Gln Asn Pro Ser Ala Gln Ala Leu 
    210                 215                 220                 


Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Gly Asp Ala Lys 
225                 230                 235                 240 


Pro Trp Cys His Val Leu Lys Asn Arg Arg Leu Thr Trp Glu Tyr Cys 
                245                 250                 255     


Asp Val Pro Ser Cys Ser Thr Cys Gly Leu Arg Gln Tyr Ser Gln Pro 
            260                 265                 270         


Gln Phe Arg Ile Lys Gly Gly Leu Phe Ala Asp Ile Ala Ser His Pro 
        275                 280                 285             


Trp Gln Ala Ala Ile Phe Ala Lys His Arg Arg Ser Pro Gly Glu Arg 
    290                 295                 300                 


Phe Leu Cys Gly Gly Ile Leu Ile Ser Ser Cys Trp Ile Leu Ser Ala 
305                 310                 315                 320 


Ala His Cys Phe Gln Glu Arg Phe Pro Pro His His Leu Thr Val Ile 
                325                 330                 335     


Leu Gly Arg Thr Tyr Arg Val Val Pro Gly Glu Glu Glu Gln Lys Phe 
            340                 345                 350         


Glu Val Glu Lys Tyr Ile Val His Lys Glu Phe Asp Asp Asp Thr Tyr 
        355                 360                 365             


Asp Asn Asp Ile Ala Leu Leu Gln Leu Lys Ser Asp Ser Ser Arg Cys 
    370                 375                 380                 


Ala Gln Glu Ser Ser Val Val Arg Thr Val Cys Leu Pro Pro Ala Asp 
385                 390                 395                 400 


Leu Gln Leu Pro Asp Trp Thr Glu Cys Glu Leu Ser Gly Tyr Gly Lys 
                405                 410                 415     


His Glu Ala Leu Ser Pro Phe Tyr Ser Glu Arg Leu Lys Glu Ala His 
            420                 425                 430         


Val Arg Leu Tyr Pro Ser Ser Arg Cys Thr Ser Gln His Leu Leu Asn 
        435                 440                 445             


Arg Thr Val Thr Asp Asn Met Leu Cys Ala Gly Asp Thr Arg Ser Gly 
    450                 455                 460                 


Gly Pro Gln Ala Asn Leu His Asp Ala Cys Gln Gly Asp Ser Gly Gly 
465                 470                 475                 480 


Pro Leu Val Cys Leu Asn Asp Gly Arg Met Thr Leu Val Gly Ile Ile 
                485                 490                 495     


Ser Trp Gly Leu Gly Cys Gly Gln Lys Asp Val Pro Gly Val Tyr Thr 
            500                 505                 510         


Lys Val Thr Asn Tyr Leu Asp Trp Ile Arg Asp Asn Met Arg Pro 
        515                 520                 525         


<210>  3
<211>  559
<212>  PRT
<213>  Rattus norvegicus

<400>  3

Met Lys Gly Glu Leu Leu Cys Val Leu Leu Leu Cys Gly Val Ala Phe 
1               5                   10                  15      


Thr Leu Pro Asp Gln Gly Ile His Arg Arg Phe Arg Arg Gly Ala Arg 
            20                  25                  30          


Ser Tyr Arg Ala Thr Cys Arg Asp Glu Gln Thr Gln Thr Thr Tyr Gln 
        35                  40                  45              


Gln His Gln Ser Trp Leu Arg Pro Met Leu Arg Gly Asn Arg Val Glu 
    50                  55                  60                  


Tyr Cys Arg Cys Asn Ser Gly Leu Ala Gln Cys His Ser Val Pro Val 
65                  70                  75                  80  


Arg Ser Cys Ser Glu Pro Arg Cys Phe Asn Gly Gly Thr Cys Gln Gln 
                85                  90                  95      


Ala Leu Tyr Phe Ser Asp Phe Val Cys Gln Cys Pro Asp Gly Phe Val 
            100                 105                 110         


Gly Lys Arg Cys Asp Ile Asp Thr Arg Ala Thr Cys Phe Glu Gly Gln 
        115                 120                 125             


Gly Ile Thr Tyr Arg Gly Thr Trp Ser Thr Ala Glu Asn Gly Ala Glu 
    130                 135                 140                 


Cys Ile Asn Trp Asn Ser Ser Ala Leu Ser Gln Lys Pro Tyr Ser Ala 
145                 150                 155                 160 


Arg Arg Pro Asn Ala Ile Lys Leu Gly Leu Gly Asn His Asn Tyr Cys 
                165                 170                 175     


Arg Asn Pro Asp Arg Asp Val Arg Pro Trp Cys Tyr Val Phe Lys Ala 
            180                 185                 190         


Gly Lys Tyr Thr Thr Glu Phe Cys Ser Thr Pro Ala Cys Pro Lys Gly 
        195                 200                 205             


Pro Thr Glu Asp Cys Tyr Val Gly Lys Gly Val Thr Tyr Arg Gly Thr 
    210                 215                 220                 


His Ser Phe Thr Thr Ser Lys Ala Ser Cys Leu Pro Trp Asn Ser Met 
225                 230                 235                 240 


Ile Leu Ile Gly Lys Thr Tyr Thr Ala Trp Arg Ala Asn Ser Gln Ala 
                245                 250                 255     


Leu Gly Leu Gly Arg His Asn Tyr Cys Arg Asn Pro Asp Gly Asp Ala 
            260                 265                 270         


Lys Pro Trp Cys His Val Met Lys Asp Arg Lys Leu Thr Arg Glu Tyr 
        275                 280                 285             


Cys Asp Met Ser Pro Cys Ser Thr Cys Gly Leu Arg Gln Tyr Lys Gln 
    290                 295                 300                 


Pro Leu Phe Arg Ile Lys Gly Gly Leu Phe Thr Asp Ile Thr Ser His 
305                 310                 315                 320 


Pro Trp Gln Ala Ala Ile Phe Val Lys Asn Lys Arg Ser Pro Gly Glu 
                325                 330                 335     


Arg Phe Leu Cys Gly Gly Val Leu Ile Ser Ser Cys Trp Val Leu Ser 
            340                 345                 350         


Ala Ala His Cys Phe Val Glu Arg Phe Pro Pro His His Leu Lys Val 
        355                 360                 365             


Val Leu Gly Arg Thr Tyr Arg Val Val Pro Gly Glu Glu Glu Gln Thr 
    370                 375                 380                 


Phe Glu Ile Glu Lys Tyr Ile Val His Lys Glu Phe Asp Asp Asp Thr 
385                 390                 395                 400 


Tyr Asp Asn Asp Ile Ala Leu Leu Gln Leu Arg Ser Asp Ser Ser Gln 
                405                 410                 415     


Cys Ala Gln Glu Ser Ser Ser Val Gly Thr Ala Cys Leu Pro Asp Pro 
            420                 425                 430         


Asp Val Gln Leu Pro Asp Trp Thr Glu Cys Glu Leu Ser Gly Tyr Gly 
        435                 440                 445             


Lys His Glu Ala Ser Ser Pro Phe Phe Ser Asp Arg Leu Lys Glu Ala 
    450                 455                 460                 


His Val Arg Leu Tyr Pro Ser Ser Arg Cys Thr Ser Gln His Leu Phe 
465                 470                 475                 480 


Asn Lys Thr Ile Thr Ser Asn Met Leu Cys Ala Gly Asp Thr Arg Thr 
                485                 490                 495     


Gly Gly Asn Gln Asp Val His Asp Ala Cys Gln Gly Asp Ser Gly Gly 
            500                 505                 510         


Pro Leu Val Cys Met Ile Asp Lys Arg Met Thr Leu Leu Gly Ile Ile 
        515                 520                 525             


Ser Trp Gly Leu Gly Cys Gly Gln Lys Asp Val Pro Gly Ile Tyr Thr 
    530                 535                 540                 


Lys Val Thr Asn Tyr Leu Asn Trp Ile Gln Asp Asn Met Lys Gln 
545                 550                 555                 


<210>  4
<211>  527
<212>  PRT
<213>  Rattus norvegicus

<400>  4

Ser Tyr Arg Ala Thr Cys Arg Asp Glu Gln Thr Gln Thr Thr Tyr Gln 
1               5                   10                  15      


Gln His Gln Ser Trp Leu Arg Pro Met Leu Arg Gly Asn Arg Val Glu 
            20                  25                  30          


Tyr Cys Arg Cys Asn Ser Gly Leu Ala Gln Cys His Ser Val Pro Val 
        35                  40                  45              


Arg Ser Cys Ser Glu Pro Arg Cys Phe Asn Gly Gly Thr Cys Gln Gln 
    50                  55                  60                  


Ala Leu Tyr Phe Ser Asp Phe Val Cys Gln Cys Pro Asp Gly Phe Val 
65                  70                  75                  80  


Gly Lys Arg Cys Asp Ile Asp Thr Arg Ala Thr Cys Phe Glu Gly Gln 
                85                  90                  95      


Gly Ile Thr Tyr Arg Gly Thr Trp Ser Thr Ala Glu Asn Gly Ala Glu 
            100                 105                 110         


Cys Ile Asn Trp Asn Ser Ser Ala Leu Ser Gln Lys Pro Tyr Ser Ala 
        115                 120                 125             


Arg Arg Pro Asn Ala Ile Lys Leu Gly Leu Gly Asn His Asn Tyr Cys 
    130                 135                 140                 


Arg Asn Pro Asp Arg Asp Val Arg Pro Trp Cys Tyr Val Phe Lys Ala 
145                 150                 155                 160 


Gly Lys Tyr Thr Thr Glu Phe Cys Ser Thr Pro Ala Cys Pro Lys Gly 
                165                 170                 175     


Pro Thr Glu Asp Cys Tyr Val Gly Lys Gly Val Thr Tyr Arg Gly Thr 
            180                 185                 190         


His Ser Phe Thr Thr Ser Lys Ala Ser Cys Leu Pro Trp Asn Ser Met 
        195                 200                 205             


Ile Leu Ile Gly Lys Thr Tyr Thr Ala Trp Arg Ala Asn Ser Gln Ala 
    210                 215                 220                 


Leu Gly Leu Gly Arg His Asn Tyr Cys Arg Asn Pro Asp Gly Asp Ala 
225                 230                 235                 240 


Lys Pro Trp Cys His Val Met Lys Asp Arg Lys Leu Thr Arg Glu Tyr 
                245                 250                 255     


Cys Asp Met Ser Pro Cys Ser Thr Cys Gly Leu Arg Gln Tyr Lys Gln 
            260                 265                 270         


Pro Leu Phe Arg Ile Lys Gly Gly Leu Phe Thr Asp Ile Thr Ser His 
        275                 280                 285             


Pro Trp Gln Ala Ala Ile Phe Val Lys Asn Lys Arg Ser Pro Gly Glu 
    290                 295                 300                 


Arg Phe Leu Cys Gly Gly Val Leu Ile Ser Ser Cys Trp Val Leu Ser 
305                 310                 315                 320 


Ala Ala His Cys Phe Val Glu Arg Phe Pro Pro His His Leu Lys Val 
                325                 330                 335     


Val Leu Gly Arg Thr Tyr Arg Val Val Pro Gly Glu Glu Glu Gln Thr 
            340                 345                 350         


Phe Glu Ile Glu Lys Tyr Ile Val His Lys Glu Phe Asp Asp Asp Thr 
        355                 360                 365             


Tyr Asp Asn Asp Ile Ala Leu Leu Gln Leu Arg Ser Asp Ser Ser Gln 
    370                 375                 380                 


Cys Ala Gln Glu Ser Ser Ser Val Gly Thr Ala Cys Leu Pro Asp Pro 
385                 390                 395                 400 


Asp Val Gln Leu Pro Asp Trp Thr Glu Cys Glu Leu Ser Gly Tyr Gly 
                405                 410                 415     


Lys His Glu Ala Ser Ser Pro Phe Phe Ser Asp Arg Leu Lys Glu Ala 
            420                 425                 430         


His Val Arg Leu Tyr Pro Ser Ser Arg Cys Thr Ser Gln His Leu Phe 
        435                 440                 445             


Asn Lys Thr Ile Thr Ser Asn Met Leu Cys Ala Gly Asp Thr Arg Thr 
    450                 455                 460                 


Gly Gly Asn Gln Asp Val His Asp Ala Cys Gln Gly Asp Ser Gly Gly 
465                 470                 475                 480 


Pro Leu Val Cys Met Ile Asp Lys Arg Met Thr Leu Leu Gly Ile Ile 
                485                 490                 495     


Ser Trp Gly Leu Gly Cys Gly Gln Lys Asp Val Pro Gly Ile Tyr Thr 
            500                 505                 510         


Lys Val Thr Asn Tyr Leu Asn Trp Ile Gln Asp Asn Met Lys Gln 
        515                 520                 525         


<210>  5
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg 
            20                  25                  30          


Gly Ala Arg Ser Tyr Gln Val Ile Cys Arg Asp Glu Lys Thr Gln Met 
        35                  40                  45              


Ile Tyr Gln Gln His Gln Ser Trp Leu Arg Pro Val Leu Arg Ser Asn 
    50                  55                  60                  


Arg Val Glu Tyr Cys Trp Cys Asn Ser Gly Arg Ala Gln Cys His Ser 
65                  70                  75                  80  


Val Pro Val Lys Ser Cys Ser Glu Pro Arg Cys Phe Asn Gly Gly Thr 
                85                  90                  95      


Cys Gln Gln Ala Leu Tyr Phe Ser Asp Phe Val Cys Gln Cys Pro Glu 
            100                 105                 110         


Gly Phe Ala Gly Lys Cys Cys Glu Ile Asp Thr Arg Ala Thr Cys Tyr 
        115                 120                 125             


Glu Asp Gln Gly Ile Ser Tyr Arg Gly Thr Trp Ser Thr Ala Glu Ser 
    130                 135                 140                 


Gly Ala Glu Cys Thr Asn Trp Asn Ser Ser Ala Leu Ala Gln Lys Pro 
145                 150                 155                 160 


Tyr Ser Gly Arg Arg Pro Asp Ala Ile Arg Leu Gly Leu Gly Asn His 
                165                 170                 175     


Asn Tyr Cys Arg Asn Pro Asp Arg Asp Ser Lys Pro Trp Cys Tyr Val 
            180                 185                 190         


Phe Lys Ala Gly Lys Tyr Ser Ser Glu Phe Cys Ser Thr Pro Ala Cys 
        195                 200                 205             


Ser Glu Gly Asn Ser Asp Cys Tyr Phe Gly Asn Gly Ser Ala Tyr Arg 
    210                 215                 220                 


Gly Thr His Ser Leu Thr Glu Ser Gly Ala Ser Cys Leu Pro Trp Asn 
225                 230                 235                 240 


Ser Met Ile Leu Ile Gly Lys Val Tyr Thr Ala Gln Asn Pro Ser Ala 
                245                 250                 255     


Gln Ala Leu Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Gly 
            260                 265                 270         


Asp Ala Lys Pro Trp Cys His Val Leu Lys Asn Arg Arg Leu Thr Arg 
        275                 280                 285             


Glu Tyr Cys Asp Val Pro Ser Cys Ser Thr Cys Gly Leu Arg Gln Tyr 
    290                 295                 300                 


Ser Gln Pro Gln Phe Arg Ile Lys Gly Gly Leu Phe Ala Asp Ile Ala 
305                 310                 315                 320 


Ser His Pro Trp Gln Ala Ala Ile Phe Ala Lys His Arg Arg Ser Pro 
                325                 330                 335     


Gly Glu Arg Phe Leu Cys Gly Gly Ile Leu Ile Ser Ser Cys Trp Ile 
            340                 345                 350         


Leu Ser Ala Ala His Cys Phe Gln Glu Arg Phe Pro Pro His His Leu 
        355                 360                 365             


Thr Val Ile Leu Gly Arg Thr Tyr Arg Val Val Pro Gly Glu Glu Glu 
    370                 375                 380                 


Gln Lys Phe Glu Val Glu Lys Tyr Ile Val His Lys Glu Phe Asp Asp 
385                 390                 395                 400 


Asp Thr Tyr Asp Asn Asp Ile Ala Leu Leu Gln Leu Lys Ser Asp Ser 
                405                 410                 415     


Ser Arg Cys Ala Gln Glu Ser Ser Val Val Arg Thr Val Cys Leu Pro 
            420                 425                 430         


Pro Ala Asp Leu Gln Leu Pro Asp Trp Thr Glu Cys Glu Leu Ser Gly 
        435                 440                 445             


Tyr Gly Lys His Glu Ala Leu Ser Pro Phe Tyr Ser Glu Arg Leu Lys 
    450                 455                 460                 


Glu Ala His Val Arg Leu Tyr Pro Ser Ser Arg Cys Thr Ser Gln His 
465                 470                 475                 480 


Leu Leu Asn Arg Thr Val Thr Asp Asn Met Leu Cys Ala Gly Asp Thr 
                485                 490                 495     


Arg Ser Gly Gly Pro Gln Ala Asn Leu His Asp Ala Cys Gln Gly Asp 
            500                 505                 510         


Ser Gly Gly Pro Leu Val Cys Leu Asn Asp Gly Arg Met Thr Leu Val 
        515                 520                 525             


Gly Ile Ile Ser Trp Gly Leu Gly Cys Gly Gln Lys Asp Val Pro Gly 
    530                 535                 540                 


Val Tyr Thr Lys Val Thr Asn Tyr Leu Asp Trp Ile Arg Asp Asn Met 
545                 550                 555                 560 


Arg Pro 
        


<210>  6
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  6

Ser Tyr Gln Val Ile Cys Arg Asp Glu Lys Thr Gln Met Ile Tyr Gln 
1               5                   10                  15      


Gln His Gln Ser Trp Leu Arg Pro Val Leu Arg Ser Asn Arg Val Glu 
            20                  25                  30          


Tyr Cys Trp Cys Asn Ser Gly Arg Ala Gln Cys His Ser Val Pro Val 
        35                  40                  45              


Lys Ser Cys Ser Glu Pro Arg Cys Phe Asn Gly Gly Thr Cys Gln Gln 
    50                  55                  60                  


Ala Leu Tyr Phe Ser Asp Phe Val Cys Gln Cys Pro Glu Gly Phe Ala 
65                  70                  75                  80  


Gly Lys Cys Cys Glu Ile Asp Thr Arg Ala Thr Cys Tyr Glu Asp Gln 
                85                  90                  95      


Gly Ile Ser Tyr Arg Gly Thr Trp Ser Thr Ala Glu Ser Gly Ala Glu 
            100                 105                 110         


Cys Thr Asn Trp Asn Ser Ser Ala Leu Ala Gln Lys Pro Tyr Ser Gly 
        115                 120                 125             


Arg Arg Pro Asp Ala Ile Arg Leu Gly Leu Gly Asn His Asn Tyr Cys 
    130                 135                 140                 


Arg Asn Pro Asp Arg Asp Ser Lys Pro Trp Cys Tyr Val Phe Lys Ala 
145                 150                 155                 160 


Gly Lys Tyr Ser Ser Glu Phe Cys Ser Thr Pro Ala Cys Ser Glu Gly 
                165                 170                 175     


Asn Ser Asp Cys Tyr Phe Gly Asn Gly Ser Ala Tyr Arg Gly Thr His 
            180                 185                 190         


Ser Leu Thr Glu Ser Gly Ala Ser Cys Leu Pro Trp Asn Ser Met Ile 
        195                 200                 205             


Leu Ile Gly Lys Val Tyr Thr Ala Gln Asn Pro Ser Ala Gln Ala Leu 
    210                 215                 220                 


Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Gly Asp Ala Lys 
225                 230                 235                 240 


Pro Trp Cys His Val Leu Lys Asn Arg Arg Leu Thr Arg Glu Tyr Cys 
                245                 250                 255     


Asp Val Pro Ser Cys Ser Thr Cys Gly Leu Arg Gln Tyr Ser Gln Pro 
            260                 265                 270         


Gln Phe Arg Ile Lys Gly Gly Leu Phe Ala Asp Ile Ala Ser His Pro 
        275                 280                 285             


Trp Gln Ala Ala Ile Phe Ala Lys His Arg Arg Ser Pro Gly Glu Arg 
    290                 295                 300                 


Phe Leu Cys Gly Gly Ile Leu Ile Ser Ser Cys Trp Ile Leu Ser Ala 
305                 310                 315                 320 


Ala His Cys Phe Gln Glu Arg Phe Pro Pro His His Leu Thr Val Ile 
                325                 330                 335     


Leu Gly Arg Thr Tyr Arg Val Val Pro Gly Glu Glu Glu Gln Lys Phe 
            340                 345                 350         


Glu Val Glu Lys Tyr Ile Val His Lys Glu Phe Asp Asp Asp Thr Tyr 
        355                 360                 365             


Asp Asn Asp Ile Ala Leu Leu Gln Leu Lys Ser Asp Ser Ser Arg Cys 
    370                 375                 380                 


Ala Gln Glu Ser Ser Val Val Arg Thr Val Cys Leu Pro Pro Ala Asp 
385                 390                 395                 400 


Leu Gln Leu Pro Asp Trp Thr Glu Cys Glu Leu Ser Gly Tyr Gly Lys 
                405                 410                 415     


His Glu Ala Leu Ser Pro Phe Tyr Ser Glu Arg Leu Lys Glu Ala His 
            420                 425                 430         


Val Arg Leu Tyr Pro Ser Ser Arg Cys Thr Ser Gln His Leu Leu Asn 
        435                 440                 445             


Arg Thr Val Thr Asp Asn Met Leu Cys Ala Gly Asp Thr Arg Ser Gly 
    450                 455                 460                 


Gly Pro Gln Ala Asn Leu His Asp Ala Cys Gln Gly Asp Ser Gly Gly 
465                 470                 475                 480 


Pro Leu Val Cys Leu Asn Asp Gly Arg Met Thr Leu Val Gly Ile Ile 
                485                 490                 495     


Ser Trp Gly Leu Gly Cys Gly Gln Lys Asp Val Pro Gly Val Tyr Thr 
            500                 505                 510         


Lys Val Thr Asn Tyr Leu Asp Trp Ile Arg Asp Asn Met Arg Pro 
        515                 520                 525         


<210>  7
<211>  559
<212>  PRT
<213>  Rattus norvegicus

<400>  7

Met Lys Gly Glu Leu Leu Cys Val Leu Leu Leu Cys Gly Val Ala Phe 
1               5                   10                  15      


Thr Leu Pro Asp Gln Gly Ile His Arg Arg Phe Arg Arg Gly Ala Arg 
            20                  25                  30          


Ser Tyr Arg Ala Thr Cys Arg Asp Glu Gln Thr Gln Thr Thr Tyr Gln 
        35                  40                  45              


Gln His Gln Ser Trp Leu Arg Pro Met Leu Arg Gly Asn Arg Val Glu 
    50                  55                  60                  


Tyr Cys Arg Cys Asn Ser Gly Leu Ala Gln Cys His Ser Val Pro Val 
65                  70                  75                  80  


Arg Ser Cys Ser Glu Pro Arg Cys Phe Asn Gly Gly Thr Cys Gln Gln 
                85                  90                  95      


Ala Leu Tyr Phe Ser Asp Phe Val Cys Gln Cys Pro Asp Gly Phe Val 
            100                 105                 110         


Gly Lys Arg Cys Asp Ile Asp Thr Arg Ala Thr Cys Phe Glu Gly Gln 
        115                 120                 125             


Gly Ile Thr Tyr Arg Gly Thr Trp Ser Thr Ala Glu Asn Gly Ala Glu 
    130                 135                 140                 


Cys Ile Asn Trp Asn Ser Ser Ala Leu Ser Gln Lys Pro Tyr Ser Ala 
145                 150                 155                 160 


Arg Arg Pro Asn Ala Ile Lys Leu Gly Leu Gly Asn His Asn Tyr Cys 
                165                 170                 175     


Arg Asn Pro Asp Arg Asp Val Arg Pro Trp Cys Tyr Val Phe Lys Ala 
            180                 185                 190         


Gly Lys Tyr Thr Thr Glu Phe Cys Ser Thr Pro Ala Cys Pro Lys Gly 
        195                 200                 205             


Pro Thr Glu Asp Cys Tyr Val Gly Lys Gly Val Thr Tyr Arg Gly Thr 
    210                 215                 220                 


His Ser Phe Thr Thr Ser Lys Ala Ser Cys Leu Pro Trp Asn Ser Met 
225                 230                 235                 240 


Ile Leu Ile Gly Lys Thr Tyr Thr Ala Trp Arg Ala Asn Ser Gln Ala 
                245                 250                 255     


Leu Gly Leu Gly Arg His Asn Tyr Cys Arg Asn Pro Asp Gly Asp Ala 
            260                 265                 270         


Lys Pro Trp Cys His Val Met Lys Asp Arg Lys Leu Thr Trp Glu Tyr 
        275                 280                 285             


Cys Asp Met Ser Pro Cys Ser Thr Cys Gly Leu Arg Gln Tyr Lys Gln 
    290                 295                 300                 


Pro Leu Phe Ser Ile Lys Gly Gly Leu Phe Thr Asp Ile Thr Ser His 
305                 310                 315                 320 


Pro Trp Gln Ala Ala Ile Phe Val Lys Asn Lys Arg Ser Pro Gly Glu 
                325                 330                 335     


Arg Phe Leu Cys Gly Gly Val Leu Ile Ser Ser Cys Trp Val Leu Ser 
            340                 345                 350         


Ala Ala His Cys Phe Val Glu Arg Phe Pro Pro His His Leu Lys Val 
        355                 360                 365             


Val Leu Gly Arg Thr Tyr Arg Val Val Pro Gly Glu Glu Glu Gln Thr 
    370                 375                 380                 


Phe Glu Ile Glu Lys Tyr Ile Val His Lys Glu Phe Asp Asp Asp Thr 
385                 390                 395                 400 


Tyr Asp Asn Asp Ile Ala Leu Leu Gln Leu Arg Ser Asp Ser Ser Gln 
                405                 410                 415     


Cys Ala Gln Glu Ser Ser Ser Val Gly Thr Ala Cys Leu Pro Asp Pro 
            420                 425                 430         


Asp Val Gln Leu Pro Asp Trp Thr Glu Cys Glu Leu Ser Gly Tyr Gly 
        435                 440                 445             


Lys His Glu Ala Ser Ser Pro Phe Phe Ser Asp Arg Leu Lys Glu Ala 
    450                 455                 460                 


His Val Arg Leu Tyr Pro Ser Ser Arg Cys Thr Ser Gln His Leu Phe 
465                 470                 475                 480 


Asn Lys Thr Ile Thr Ser Asn Met Leu Cys Ala Gly Asp Thr Arg Thr 
                485                 490                 495     


Gly Gly Asn Gln Asp Val His Asp Ala Cys Gln Gly Asp Ser Gly Gly 
            500                 505                 510         


Pro Leu Val Cys Met Ile Asp Lys Arg Met Thr Leu Leu Gly Ile Ile 
        515                 520                 525             


Ser Trp Gly Leu Gly Cys Gly Gln Lys Asp Val Pro Gly Ile Tyr Thr 
    530                 535                 540                 


Lys Val Thr Asn Tyr Leu Asn Trp Ile Gln Asp Asn Met Lys Gln 
545                 550                 555                 


<210>  8
<211>  527
<212>  PRT
<213>  Rattus norvegicus

<400>  8

Ser Tyr Arg Ala Thr Cys Arg Asp Glu Gln Thr Gln Thr Thr Tyr Gln 
1               5                   10                  15      


Gln His Gln Ser Trp Leu Arg Pro Met Leu Arg Gly Asn Arg Val Glu 
            20                  25                  30          


Tyr Cys Arg Cys Asn Ser Gly Leu Ala Gln Cys His Ser Val Pro Val 
        35                  40                  45              


Arg Ser Cys Ser Glu Pro Arg Cys Phe Asn Gly Gly Thr Cys Gln Gln 
    50                  55                  60                  


Ala Leu Tyr Phe Ser Asp Phe Val Cys Gln Cys Pro Asp Gly Phe Val 
65                  70                  75                  80  


Gly Lys Arg Cys Asp Ile Asp Thr Arg Ala Thr Cys Phe Glu Gly Gln 
                85                  90                  95      


Gly Ile Thr Tyr Arg Gly Thr Trp Ser Thr Ala Glu Asn Gly Ala Glu 
            100                 105                 110         


Cys Ile Asn Trp Asn Ser Ser Ala Leu Ser Gln Lys Pro Tyr Ser Ala 
        115                 120                 125             


Arg Arg Pro Asn Ala Ile Lys Leu Gly Leu Gly Asn His Asn Tyr Cys 
    130                 135                 140                 


Arg Asn Pro Asp Arg Asp Val Arg Pro Trp Cys Tyr Val Phe Lys Ala 
145                 150                 155                 160 


Gly Lys Tyr Thr Thr Glu Phe Cys Ser Thr Pro Ala Cys Pro Lys Gly 
                165                 170                 175     


Pro Thr Glu Asp Cys Tyr Val Gly Lys Gly Val Thr Tyr Arg Gly Thr 
            180                 185                 190         


His Ser Phe Thr Thr Ser Lys Ala Ser Cys Leu Pro Trp Asn Ser Met 
        195                 200                 205             


Ile Leu Ile Gly Lys Thr Tyr Thr Ala Trp Arg Ala Asn Ser Gln Ala 
    210                 215                 220                 


Leu Gly Leu Gly Arg His Asn Tyr Cys Arg Asn Pro Asp Gly Asp Ala 
225                 230                 235                 240 


Lys Pro Trp Cys His Val Met Lys Asp Arg Lys Leu Thr Trp Glu Tyr 
                245                 250                 255     


Cys Asp Met Ser Pro Cys Ser Thr Cys Gly Leu Arg Gln Tyr Lys Gln 
            260                 265                 270         


Pro Leu Phe Ser Ile Lys Gly Gly Leu Phe Thr Asp Ile Thr Ser His 
        275                 280                 285             


Pro Trp Gln Ala Ala Ile Phe Val Lys Asn Lys Arg Ser Pro Gly Glu 
    290                 295                 300                 


Arg Phe Leu Cys Gly Gly Val Leu Ile Ser Ser Cys Trp Val Leu Ser 
305                 310                 315                 320 


Ala Ala His Cys Phe Val Glu Arg Phe Pro Pro His His Leu Lys Val 
                325                 330                 335     


Val Leu Gly Arg Thr Tyr Arg Val Val Pro Gly Glu Glu Glu Gln Thr 
            340                 345                 350         


Phe Glu Ile Glu Lys Tyr Ile Val His Lys Glu Phe Asp Asp Asp Thr 
        355                 360                 365             


Tyr Asp Asn Asp Ile Ala Leu Leu Gln Leu Arg Ser Asp Ser Ser Gln 
    370                 375                 380                 


Cys Ala Gln Glu Ser Ser Ser Val Gly Thr Ala Cys Leu Pro Asp Pro 
385                 390                 395                 400 


Asp Val Gln Leu Pro Asp Trp Thr Glu Cys Glu Leu Ser Gly Tyr Gly 
                405                 410                 415     


Lys His Glu Ala Ser Ser Pro Phe Phe Ser Asp Arg Leu Lys Glu Ala 
            420                 425                 430         


His Val Arg Leu Tyr Pro Ser Ser Arg Cys Thr Ser Gln His Leu Phe 
        435                 440                 445             


Asn Lys Thr Ile Thr Ser Asn Met Leu Cys Ala Gly Asp Thr Arg Thr 
    450                 455                 460                 


Gly Gly Asn Gln Asp Val His Asp Ala Cys Gln Gly Asp Ser Gly Gly 
465                 470                 475                 480 


Pro Leu Val Cys Met Ile Asp Lys Arg Met Thr Leu Leu Gly Ile Ile 
                485                 490                 495     


Ser Trp Gly Leu Gly Cys Gly Gln Lys Asp Val Pro Gly Ile Tyr Thr 
            500                 505                 510         


Lys Val Thr Asn Tyr Leu Asn Trp Ile Gln Asp Asn Met Lys Gln 
        515                 520                 525         


<210>  9
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg 
            20                  25                  30          


Gly Ala Arg Ser Tyr Gln Val Ile Cys Arg Asp Glu Lys Thr Gln Met 
        35                  40                  45              


Ile Tyr Gln Gln His Gln Ser Trp Leu Arg Pro Val Leu Arg Ser Asn 
    50                  55                  60                  


Arg Val Glu Tyr Cys Trp Cys Asn Ser Gly Arg Ala Gln Cys His Ser 
65                  70                  75                  80  


Val Pro Val Lys Ser Cys Ser Glu Pro Arg Cys Phe Asn Gly Gly Thr 
                85                  90                  95      


Cys Gln Gln Ala Leu Tyr Phe Ser Asp Phe Val Cys Gln Cys Pro Glu 
            100                 105                 110         


Gly Phe Ala Gly Lys Cys Cys Glu Ile Asp Thr Arg Ala Thr Cys Tyr 
        115                 120                 125             


Glu Asp Gln Gly Ile Ser Tyr Arg Gly Thr Trp Ser Thr Ala Glu Ser 
    130                 135                 140                 


Gly Ala Glu Cys Thr Asn Trp Asn Ser Ser Ala Leu Ala Gln Lys Pro 
145                 150                 155                 160 


Tyr Ser Gly Arg Arg Pro Asp Ala Ile Arg Leu Gly Leu Gly Asn His 
                165                 170                 175     


Asn Tyr Cys Arg Asn Pro Asp Arg Asp Ser Lys Pro Trp Cys Tyr Val 
            180                 185                 190         


Phe Lys Ala Gly Lys Tyr Ser Ser Glu Phe Cys Ser Thr Pro Ala Cys 
        195                 200                 205             


Ser Glu Gly Asn Ser Asp Cys Tyr Phe Gly Asn Gly Ser Ala Tyr Arg 
    210                 215                 220                 


Gly Thr His Ser Leu Thr Glu Ser Gly Ala Ser Cys Leu Pro Trp Asn 
225                 230                 235                 240 


Ser Met Ile Leu Ile Gly Lys Val Tyr Thr Ala Gln Asn Pro Ser Ala 
                245                 250                 255     


Gln Ala Leu Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Gly 
            260                 265                 270         


Asp Ala Lys Pro Trp Cys His Val Leu Lys Asn Arg Arg Leu Thr Trp 
        275                 280                 285             


Glu Tyr Cys Asp Val Pro Ser Cys Ser Thr Cys Gly Leu Arg Gln Tyr 
    290                 295                 300                 


Ser Gln Pro Gln Phe Ser Ile Lys Gly Gly Leu Phe Ala Asp Ile Ala 
305                 310                 315                 320 


Ser His Pro Trp Gln Ala Ala Ile Phe Ala Lys His Arg Arg Ser Pro 
                325                 330                 335     


Gly Glu Arg Phe Leu Cys Gly Gly Ile Leu Ile Ser Ser Cys Trp Ile 
            340                 345                 350         


Leu Ser Ala Ala His Cys Phe Gln Glu Arg Phe Pro Pro His His Leu 
        355                 360                 365             


Thr Val Ile Leu Gly Arg Thr Tyr Arg Val Val Pro Gly Glu Glu Glu 
    370                 375                 380                 


Gln Lys Phe Glu Val Glu Lys Tyr Ile Val His Lys Glu Phe Asp Asp 
385                 390                 395                 400 


Asp Thr Tyr Asp Asn Asp Ile Ala Leu Leu Gln Leu Lys Ser Asp Ser 
                405                 410                 415     


Ser Arg Cys Ala Gln Glu Ser Ser Val Val Arg Thr Val Cys Leu Pro 
            420                 425                 430         


Pro Ala Asp Leu Gln Leu Pro Asp Trp Thr Glu Cys Glu Leu Ser Gly 
        435                 440                 445             


Tyr Gly Lys His Glu Ala Leu Ser Pro Phe Tyr Ser Glu Arg Leu Lys 
    450                 455                 460                 


Glu Ala His Val Arg Leu Tyr Pro Ser Ser Arg Cys Thr Ser Gln His 
465                 470                 475                 480 


Leu Leu Asn Arg Thr Val Thr Asp Asn Met Leu Cys Ala Gly Asp Thr 
                485                 490                 495     


Arg Ser Gly Gly Pro Gln Ala Asn Leu His Asp Ala Cys Gln Gly Asp 
            500                 505                 510         


Ser Gly Gly Pro Leu Val Cys Leu Asn Asp Gly Arg Met Thr Leu Val 
        515                 520                 525             


Gly Ile Ile Ser Trp Gly Leu Gly Cys Gly Gln Lys Asp Val Pro Gly 
    530                 535                 540                 


Val Tyr Thr Lys Val Thr Asn Tyr Leu Asp Trp Ile Arg Asp Asn Met 
545                 550                 555                 560 


Arg Pro 
        


<210>  10
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  10

Ser Tyr Gln Val Ile Cys Arg Asp Glu Lys Thr Gln Met Ile Tyr Gln 
1               5                   10                  15      


Gln His Gln Ser Trp Leu Arg Pro Val Leu Arg Ser Asn Arg Val Glu 
            20                  25                  30          


Tyr Cys Trp Cys Asn Ser Gly Arg Ala Gln Cys His Ser Val Pro Val 
        35                  40                  45              


Lys Ser Cys Ser Glu Pro Arg Cys Phe Asn Gly Gly Thr Cys Gln Gln 
    50                  55                  60                  


Ala Leu Tyr Phe Ser Asp Phe Val Cys Gln Cys Pro Glu Gly Phe Ala 
65                  70                  75                  80  


Gly Lys Cys Cys Glu Ile Asp Thr Arg Ala Thr Cys Tyr Glu Asp Gln 
                85                  90                  95      


Gly Ile Ser Tyr Arg Gly Thr Trp Ser Thr Ala Glu Ser Gly Ala Glu 
            100                 105                 110         


Cys Thr Asn Trp Asn Ser Ser Ala Leu Ala Gln Lys Pro Tyr Ser Gly 
        115                 120                 125             


Arg Arg Pro Asp Ala Ile Arg Leu Gly Leu Gly Asn His Asn Tyr Cys 
    130                 135                 140                 


Arg Asn Pro Asp Arg Asp Ser Lys Pro Trp Cys Tyr Val Phe Lys Ala 
145                 150                 155                 160 


Gly Lys Tyr Ser Ser Glu Phe Cys Ser Thr Pro Ala Cys Ser Glu Gly 
                165                 170                 175     


Asn Ser Asp Cys Tyr Phe Gly Asn Gly Ser Ala Tyr Arg Gly Thr His 
            180                 185                 190         


Ser Leu Thr Glu Ser Gly Ala Ser Cys Leu Pro Trp Asn Ser Met Ile 
        195                 200                 205             


Leu Ile Gly Lys Val Tyr Thr Ala Gln Asn Pro Ser Ala Gln Ala Leu 
    210                 215                 220                 


Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Gly Asp Ala Lys 
225                 230                 235                 240 


Pro Trp Cys His Val Leu Lys Asn Arg Arg Leu Thr Trp Glu Tyr Cys 
                245                 250                 255     


Asp Val Pro Ser Cys Ser Thr Cys Gly Leu Arg Gln Tyr Ser Gln Pro 
            260                 265                 270         


Gln Phe Ser Ile Lys Gly Gly Leu Phe Ala Asp Ile Ala Ser His Pro 
        275                 280                 285             


Trp Gln Ala Ala Ile Phe Ala Lys His Arg Arg Ser Pro Gly Glu Arg 
    290                 295                 300                 


Phe Leu Cys Gly Gly Ile Leu Ile Ser Ser Cys Trp Ile Leu Ser Ala 
305                 310                 315                 320 


Ala His Cys Phe Gln Glu Arg Phe Pro Pro His His Leu Thr Val Ile 
                325                 330                 335     


Leu Gly Arg Thr Tyr Arg Val Val Pro Gly Glu Glu Glu Gln Lys Phe 
            340                 345                 350         


Glu Val Glu Lys Tyr Ile Val His Lys Glu Phe Asp Asp Asp Thr Tyr 
        355                 360                 365             


Asp Asn Asp Ile Ala Leu Leu Gln Leu Lys Ser Asp Ser Ser Arg Cys 
    370                 375                 380                 


Ala Gln Glu Ser Ser Val Val Arg Thr Val Cys Leu Pro Pro Ala Asp 
385                 390                 395                 400 


Leu Gln Leu Pro Asp Trp Thr Glu Cys Glu Leu Ser Gly Tyr Gly Lys 
                405                 410                 415     


His Glu Ala Leu Ser Pro Phe Tyr Ser Glu Arg Leu Lys Glu Ala His 
            420                 425                 430         


Val Arg Leu Tyr Pro Ser Ser Arg Cys Thr Ser Gln His Leu Leu Asn 
        435                 440                 445             


Arg Thr Val Thr Asp Asn Met Leu Cys Ala Gly Asp Thr Arg Ser Gly 
    450                 455                 460                 


Gly Pro Gln Ala Asn Leu His Asp Ala Cys Gln Gly Asp Ser Gly Gly 
465                 470                 475                 480 


Pro Leu Val Cys Leu Asn Asp Gly Arg Met Thr Leu Val Gly Ile Ile 
                485                 490                 495     


Ser Trp Gly Leu Gly Cys Gly Gln Lys Asp Val Pro Gly Val Tyr Thr 
            500                 505                 510         


Lys Val Thr Asn Tyr Leu Asp Trp Ile Arg Asp Asn Met Arg Pro 
        515                 520                 525         


<210>  11
<211>  559
<212>  PRT
<213>  Rattus norvegicus

<400>  11

Met Lys Gly Glu Leu Leu Cys Val Leu Leu Leu Cys Gly Val Ala Phe 
1               5                   10                  15      


Thr Leu Pro Asp Gln Gly Ile His Arg Arg Phe Arg Arg Gly Ala Arg 
            20                  25                  30          


Ser Tyr Arg Ala Thr Cys Arg Asp Glu Gln Thr Gln Thr Thr Tyr Gln 
        35                  40                  45              


Gln His Gln Ser Trp Leu Arg Pro Met Leu Arg Gly Asn Arg Val Glu 
    50                  55                  60                  


Tyr Cys Arg Cys Asn Ser Gly Leu Ala Gln Cys His Ser Val Pro Val 
65                  70                  75                  80  


Arg Ser Cys Ser Glu Pro Arg Cys Phe Asn Gly Gly Thr Cys Gln Gln 
                85                  90                  95      


Ala Leu Tyr Phe Ser Asp Phe Val Cys Gln Cys Pro Asp Gly Phe Val 
            100                 105                 110         


Gly Lys Arg Cys Asp Ile Asp Thr Arg Ala Thr Cys Phe Glu Gly Gln 
        115                 120                 125             


Gly Ile Thr Tyr Arg Gly Thr Trp Ser Thr Ala Glu Asn Gly Ala Glu 
    130                 135                 140                 


Cys Ile Asn Trp Asn Ser Ser Ala Leu Ser Gln Lys Pro Tyr Ser Ala 
145                 150                 155                 160 


Arg Arg Pro Asn Ala Ile Lys Leu Gly Leu Gly Asn His Asn Tyr Cys 
                165                 170                 175     


Arg Asn Pro Asp Arg Asp Val Arg Pro Trp Cys Tyr Val Phe Lys Ala 
            180                 185                 190         


Gly Lys Tyr Thr Thr Glu Phe Cys Ser Thr Pro Ala Cys Pro Lys Gly 
        195                 200                 205             


Pro Thr Glu Asp Cys Tyr Val Gly Lys Gly Val Thr Tyr Arg Gly Thr 
    210                 215                 220                 


His Ser Phe Thr Thr Ser Lys Ala Ser Cys Leu Pro Trp Asn Ser Met 
225                 230                 235                 240 


Ile Leu Ile Gly Lys Thr Tyr Thr Ala Trp Arg Ala Asn Ser Gln Ala 
                245                 250                 255     


Leu Gly Leu Gly Arg His Asn Tyr Cys Arg Asn Pro Asp Gly Asp Ala 
            260                 265                 270         


Lys Pro Trp Cys His Val Met Lys Asp Arg Lys Leu Thr Arg Glu Tyr 
        275                 280                 285             


Cys Asp Met Ser Pro Cys Ser Thr Cys Gly Leu Arg Gln Tyr Lys Gln 
    290                 295                 300                 


Pro Leu Phe Ser Ile Lys Gly Gly Leu Phe Thr Asp Ile Thr Ser His 
305                 310                 315                 320 


Pro Trp Gln Ala Ala Ile Phe Val Lys Asn Lys Arg Ser Pro Gly Glu 
                325                 330                 335     


Arg Phe Leu Cys Gly Gly Val Leu Ile Ser Ser Cys Trp Val Leu Ser 
            340                 345                 350         


Ala Ala His Cys Phe Val Glu Arg Phe Pro Pro His His Leu Lys Val 
        355                 360                 365             


Val Leu Gly Arg Thr Tyr Arg Val Val Pro Gly Glu Glu Glu Gln Thr 
    370                 375                 380                 


Phe Glu Ile Glu Lys Tyr Ile Val His Lys Glu Phe Asp Asp Asp Thr 
385                 390                 395                 400 


Tyr Asp Asn Asp Ile Ala Leu Leu Gln Leu Arg Ser Asp Ser Ser Gln 
                405                 410                 415     


Cys Ala Gln Glu Ser Ser Ser Val Gly Thr Ala Cys Leu Pro Asp Pro 
            420                 425                 430         


Asp Val Gln Leu Pro Asp Trp Thr Glu Cys Glu Leu Ser Gly Tyr Gly 
        435                 440                 445             


Lys His Glu Ala Ser Ser Pro Phe Phe Ser Asp Arg Leu Lys Glu Ala 
    450                 455                 460                 


His Val Arg Leu Tyr Pro Ser Ser Arg Cys Thr Ser Gln His Leu Phe 
465                 470                 475                 480 


Asn Lys Thr Ile Thr Ser Asn Met Leu Cys Ala Gly Asp Thr Arg Thr 
                485                 490                 495     


Gly Gly Asn Gln Asp Val His Asp Ala Cys Gln Gly Asp Ser Gly Gly 
            500                 505                 510         


Pro Leu Val Cys Met Ile Asp Lys Arg Met Thr Leu Leu Gly Ile Ile 
        515                 520                 525             


Ser Trp Gly Leu Gly Cys Gly Gln Lys Asp Val Pro Gly Ile Tyr Thr 
    530                 535                 540                 


Lys Val Thr Asn Tyr Leu Asn Trp Ile Gln Asp Asn Met Lys Gln 
545                 550                 555                 


<210>  12
<211>  527
<212>  PRT
<213>  Rattus norvegicus

<400>  12

Ser Tyr Arg Ala Thr Cys Arg Asp Glu Gln Thr Gln Thr Thr Tyr Gln 
1               5                   10                  15      


Gln His Gln Ser Trp Leu Arg Pro Met Leu Arg Gly Asn Arg Val Glu 
            20                  25                  30          


Tyr Cys Arg Cys Asn Ser Gly Leu Ala Gln Cys His Ser Val Pro Val 
        35                  40                  45              


Arg Ser Cys Ser Glu Pro Arg Cys Phe Asn Gly Gly Thr Cys Gln Gln 
    50                  55                  60                  


Ala Leu Tyr Phe Ser Asp Phe Val Cys Gln Cys Pro Asp Gly Phe Val 
65                  70                  75                  80  


Gly Lys Arg Cys Asp Ile Asp Thr Arg Ala Thr Cys Phe Glu Gly Gln 
                85                  90                  95      


Gly Ile Thr Tyr Arg Gly Thr Trp Ser Thr Ala Glu Asn Gly Ala Glu 
            100                 105                 110         


Cys Ile Asn Trp Asn Ser Ser Ala Leu Ser Gln Lys Pro Tyr Ser Ala 
        115                 120                 125             


Arg Arg Pro Asn Ala Ile Lys Leu Gly Leu Gly Asn His Asn Tyr Cys 
    130                 135                 140                 


Arg Asn Pro Asp Arg Asp Val Arg Pro Trp Cys Tyr Val Phe Lys Ala 
145                 150                 155                 160 


Gly Lys Tyr Thr Thr Glu Phe Cys Ser Thr Pro Ala Cys Pro Lys Gly 
                165                 170                 175     


Pro Thr Glu Asp Cys Tyr Val Gly Lys Gly Val Thr Tyr Arg Gly Thr 
            180                 185                 190         


His Ser Phe Thr Thr Ser Lys Ala Ser Cys Leu Pro Trp Asn Ser Met 
        195                 200                 205             


Ile Leu Ile Gly Lys Thr Tyr Thr Ala Trp Arg Ala Asn Ser Gln Ala 
    210                 215                 220                 


Leu Gly Leu Gly Arg His Asn Tyr Cys Arg Asn Pro Asp Gly Asp Ala 
225                 230                 235                 240 


Lys Pro Trp Cys His Val Met Lys Asp Arg Lys Leu Thr Arg Glu Tyr 
                245                 250                 255     


Cys Asp Met Ser Pro Cys Ser Thr Cys Gly Leu Arg Gln Tyr Lys Gln 
            260                 265                 270         


Pro Leu Phe Ser Ile Lys Gly Gly Leu Phe Thr Asp Ile Thr Ser His 
        275                 280                 285             


Pro Trp Gln Ala Ala Ile Phe Val Lys Asn Lys Arg Ser Pro Gly Glu 
    290                 295                 300                 


Arg Phe Leu Cys Gly Gly Val Leu Ile Ser Ser Cys Trp Val Leu Ser 
305                 310                 315                 320 


Ala Ala His Cys Phe Val Glu Arg Phe Pro Pro His His Leu Lys Val 
                325                 330                 335     


Val Leu Gly Arg Thr Tyr Arg Val Val Pro Gly Glu Glu Glu Gln Thr 
            340                 345                 350         


Phe Glu Ile Glu Lys Tyr Ile Val His Lys Glu Phe Asp Asp Asp Thr 
        355                 360                 365             


Tyr Asp Asn Asp Ile Ala Leu Leu Gln Leu Arg Ser Asp Ser Ser Gln 
    370                 375                 380                 


Cys Ala Gln Glu Ser Ser Ser Val Gly Thr Ala Cys Leu Pro Asp Pro 
385                 390                 395                 400 


Asp Val Gln Leu Pro Asp Trp Thr Glu Cys Glu Leu Ser Gly Tyr Gly 
                405                 410                 415     


Lys His Glu Ala Ser Ser Pro Phe Phe Ser Asp Arg Leu Lys Glu Ala 
            420                 425                 430         


His Val Arg Leu Tyr Pro Ser Ser Arg Cys Thr Ser Gln His Leu Phe 
        435                 440                 445             


Asn Lys Thr Ile Thr Ser Asn Met Leu Cys Ala Gly Asp Thr Arg Thr 
    450                 455                 460                 


Gly Gly Asn Gln Asp Val His Asp Ala Cys Gln Gly Asp Ser Gly Gly 
465                 470                 475                 480 


Pro Leu Val Cys Met Ile Asp Lys Arg Met Thr Leu Leu Gly Ile Ile 
                485                 490                 495     


Ser Trp Gly Leu Gly Cys Gly Gln Lys Asp Val Pro Gly Ile Tyr Thr 
            500                 505                 510         


Lys Val Thr Asn Tyr Leu Asn Trp Ile Gln Asp Asn Met Lys Gln 
        515                 520                 525         


<210>  13
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg 
            20                  25                  30          


Gly Ala Arg Ser Tyr Gln Val Ile Cys Arg Asp Glu Lys Thr Gln Met 
        35                  40                  45              


Ile Tyr Gln Gln His Gln Ser Trp Leu Arg Pro Val Leu Arg Ser Asn 
    50                  55                  60                  


Arg Val Glu Tyr Cys Trp Cys Asn Ser Gly Arg Ala Gln Cys His Ser 
65                  70                  75                  80  


Val Pro Val Lys Ser Cys Ser Glu Pro Arg Cys Phe Asn Gly Gly Thr 
                85                  90                  95      


Cys Gln Gln Ala Leu Tyr Phe Ser Asp Phe Val Cys Gln Cys Pro Glu 
            100                 105                 110         


Gly Phe Ala Gly Lys Cys Cys Glu Ile Asp Thr Arg Ala Thr Cys Tyr 
        115                 120                 125             


Glu Asp Gln Gly Ile Ser Tyr Arg Gly Thr Trp Ser Thr Ala Glu Ser 
    130                 135                 140                 


Gly Ala Glu Cys Thr Asn Trp Asn Ser Ser Ala Leu Ala Gln Lys Pro 
145                 150                 155                 160 


Tyr Ser Gly Arg Arg Pro Asp Ala Ile Arg Leu Gly Leu Gly Asn His 
                165                 170                 175     


Asn Tyr Cys Arg Asn Pro Asp Arg Asp Ser Lys Pro Trp Cys Tyr Val 
            180                 185                 190         


Phe Lys Ala Gly Lys Tyr Ser Ser Glu Phe Cys Ser Thr Pro Ala Cys 
        195                 200                 205             


Ser Glu Gly Asn Ser Asp Cys Tyr Phe Gly Asn Gly Ser Ala Tyr Arg 
    210                 215                 220                 


Gly Thr His Ser Leu Thr Glu Ser Gly Ala Ser Cys Leu Pro Trp Asn 
225                 230                 235                 240 


Ser Met Ile Leu Ile Gly Lys Val Tyr Thr Ala Gln Asn Pro Ser Ala 
                245                 250                 255     


Gln Ala Leu Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Gly 
            260                 265                 270         


Asp Ala Lys Pro Trp Cys His Val Leu Lys Asn Arg Arg Leu Thr Arg 
        275                 280                 285             


Glu Tyr Cys Asp Val Pro Ser Cys Ser Thr Cys Gly Leu Arg Gln Tyr 
    290                 295                 300                 


Ser Gln Pro Gln Phe Ser Ile Lys Gly Gly Leu Phe Ala Asp Ile Ala 
305                 310                 315                 320 


Ser His Pro Trp Gln Ala Ala Ile Phe Ala Lys His Arg Arg Ser Pro 
                325                 330                 335     


Gly Glu Arg Phe Leu Cys Gly Gly Ile Leu Ile Ser Ser Cys Trp Ile 
            340                 345                 350         


Leu Ser Ala Ala His Cys Phe Gln Glu Arg Phe Pro Pro His His Leu 
        355                 360                 365             


Thr Val Ile Leu Gly Arg Thr Tyr Arg Val Val Pro Gly Glu Glu Glu 
    370                 375                 380                 


Gln Lys Phe Glu Val Glu Lys Tyr Ile Val His Lys Glu Phe Asp Asp 
385                 390                 395                 400 


Asp Thr Tyr Asp Asn Asp Ile Ala Leu Leu Gln Leu Lys Ser Asp Ser 
                405                 410                 415     


Ser Arg Cys Ala Gln Glu Ser Ser Val Val Arg Thr Val Cys Leu Pro 
            420                 425                 430         


Pro Ala Asp Leu Gln Leu Pro Asp Trp Thr Glu Cys Glu Leu Ser Gly 
        435                 440                 445             


Tyr Gly Lys His Glu Ala Leu Ser Pro Phe Tyr Ser Glu Arg Leu Lys 
    450                 455                 460                 


Glu Ala His Val Arg Leu Tyr Pro Ser Ser Arg Cys Thr Ser Gln His 
465                 470                 475                 480 


Leu Leu Asn Arg Thr Val Thr Asp Asn Met Leu Cys Ala Gly Asp Thr 
                485                 490                 495     


Arg Ser Gly Gly Pro Gln Ala Asn Leu His Asp Ala Cys Gln Gly Asp 
            500                 505                 510         


Ser Gly Gly Pro Leu Val Cys Leu Asn Asp Gly Arg Met Thr Leu Val 
        515                 520                 525             


Gly Ile Ile Ser Trp Gly Leu Gly Cys Gly Gln Lys Asp Val Pro Gly 
    530                 535                 540                 


Val Tyr Thr Lys Val Thr Asn Tyr Leu Asp Trp Ile Arg Asp Asn Met 
545                 550                 555                 560 


Arg Pro 
        


<210>  14
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  14

Ser Tyr Gln Val Ile Cys Arg Asp Glu Lys Thr Gln Met Ile Tyr Gln 
1               5                   10                  15      


Gln His Gln Ser Trp Leu Arg Pro Val Leu Arg Ser Asn Arg Val Glu 
            20                  25                  30          


Tyr Cys Trp Cys Asn Ser Gly Arg Ala Gln Cys His Ser Val Pro Val 
        35                  40                  45              


Lys Ser Cys Ser Glu Pro Arg Cys Phe Asn Gly Gly Thr Cys Gln Gln 
    50                  55                  60                  


Ala Leu Tyr Phe Ser Asp Phe Val Cys Gln Cys Pro Glu Gly Phe Ala 
65                  70                  75                  80  


Gly Lys Cys Cys Glu Ile Asp Thr Arg Ala Thr Cys Tyr Glu Asp Gln 
                85                  90                  95      


Gly Ile Ser Tyr Arg Gly Thr Trp Ser Thr Ala Glu Ser Gly Ala Glu 
            100                 105                 110         


Cys Thr Asn Trp Asn Ser Ser Ala Leu Ala Gln Lys Pro Tyr Ser Gly 
        115                 120                 125             


Arg Arg Pro Asp Ala Ile Arg Leu Gly Leu Gly Asn His Asn Tyr Cys 
    130                 135                 140                 


Arg Asn Pro Asp Arg Asp Ser Lys Pro Trp Cys Tyr Val Phe Lys Ala 
145                 150                 155                 160 


Gly Lys Tyr Ser Ser Glu Phe Cys Ser Thr Pro Ala Cys Ser Glu Gly 
                165                 170                 175     


Asn Ser Asp Cys Tyr Phe Gly Asn Gly Ser Ala Tyr Arg Gly Thr His 
            180                 185                 190         


Ser Leu Thr Glu Ser Gly Ala Ser Cys Leu Pro Trp Asn Ser Met Ile 
        195                 200                 205             


Leu Ile Gly Lys Val Tyr Thr Ala Gln Asn Pro Ser Ala Gln Ala Leu 
    210                 215                 220                 


Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Gly Asp Ala Lys 
225                 230                 235                 240 


Pro Trp Cys His Val Leu Lys Asn Arg Arg Leu Thr Arg Glu Tyr Cys 
                245                 250                 255     


Asp Val Pro Ser Cys Ser Thr Cys Gly Leu Arg Gln Tyr Ser Gln Pro 
            260                 265                 270         


Gln Phe Ser Ile Lys Gly Gly Leu Phe Ala Asp Ile Ala Ser His Pro 
        275                 280                 285             


Trp Gln Ala Ala Ile Phe Ala Lys His Arg Arg Ser Pro Gly Glu Arg 
    290                 295                 300                 


Phe Leu Cys Gly Gly Ile Leu Ile Ser Ser Cys Trp Ile Leu Ser Ala 
305                 310                 315                 320 


Ala His Cys Phe Gln Glu Arg Phe Pro Pro His His Leu Thr Val Ile 
                325                 330                 335     


Leu Gly Arg Thr Tyr Arg Val Val Pro Gly Glu Glu Glu Gln Lys Phe 
            340                 345                 350         


Glu Val Glu Lys Tyr Ile Val His Lys Glu Phe Asp Asp Asp Thr Tyr 
        355                 360                 365             


Asp Asn Asp Ile Ala Leu Leu Gln Leu Lys Ser Asp Ser Ser Arg Cys 
    370                 375                 380                 


Ala Gln Glu Ser Ser Val Val Arg Thr Val Cys Leu Pro Pro Ala Asp 
385                 390                 395                 400 


Leu Gln Leu Pro Asp Trp Thr Glu Cys Glu Leu Ser Gly Tyr Gly Lys 
                405                 410                 415     


His Glu Ala Leu Ser Pro Phe Tyr Ser Glu Arg Leu Lys Glu Ala His 
            420                 425                 430         


Val Arg Leu Tyr Pro Ser Ser Arg Cys Thr Ser Gln His Leu Leu Asn 
        435                 440                 445             


Arg Thr Val Thr Asp Asn Met Leu Cys Ala Gly Asp Thr Arg Ser Gly 
    450                 455                 460                 


Gly Pro Gln Ala Asn Leu His Asp Ala Cys Gln Gly Asp Ser Gly Gly 
465                 470                 475                 480 


Pro Leu Val Cys Leu Asn Asp Gly Arg Met Thr Leu Val Gly Ile Ile 
                485                 490                 495     


Ser Trp Gly Leu Gly Cys Gly Gln Lys Asp Val Pro Gly Val Tyr Thr 
            500                 505                 510         


Lys Val Thr Asn Tyr Leu Asp Trp Ile Arg Asp Asn Met Arg Pro 
        515                 520                 525         


<210>  15
<211>  1734
<212>  PRT
<213>  Rattus norvegicus

<400>  15

Ala Thr Gly Ala Ala Gly Gly Gly Ala Gly Ala Gly Cys Thr Gly Thr 
1               5                   10                  15      


Thr Gly Thr Gly Cys Gly Thr Cys Cys Thr Gly Cys Thr Gly Cys Thr 
            20                  25                  30          


Thr Thr Gly Thr Gly Gly Ala Gly Thr Gly Gly Cys Gly Thr Thr Cys 
        35                  40                  45              


Ala Cys Gly Thr Thr Gly Cys Cys Thr Gly Ala Cys Cys Ala Gly Gly 
    50                  55                  60                  


Gly Ala Ala Thr Ala Cys Ala Cys Ala Gly Gly Ala Gly Gly Thr Thr 
65                  70                  75                  80  


Cys Ala Gly Ala Ala Gly Ala Gly Gly Ala Gly Cys Thr Cys Gly Gly 
                85                  90                  95      


Cys Ala Thr Cys Ala Cys Cys Ala Thr Cys Ala Cys Cys Ala Thr Cys 
            100                 105                 110         


Ala Cys Gly Gly Ala Thr Cys Cys Thr Cys Cys Thr Ala Cys Ala Gly 
        115                 120                 125             


Ala Gly Cys Gly Ala Cys Cys Thr Gly Cys Ala Gly Ala Gly Ala Thr 
    130                 135                 140                 


Gly Ala Ala Cys Ala Gly Ala Cys Thr Cys Ala Gly Ala Cys Ala Ala 
145                 150                 155                 160 


Cys Thr Thr Ala Cys Cys Ala Ala Cys Ala Gly Cys Ala Thr Cys Ala 
                165                 170                 175     


Gly Thr Cys Ala Thr Gly Gly Cys Thr Ala Cys Gly Thr Cys Cys Cys 
            180                 185                 190         


Ala Thr Gly Cys Thr Cys Ala Gly Ala Gly Gly Cys Ala Ala Thr Cys 
        195                 200                 205             


Gly Gly Gly Thr Gly Gly Ala Ala Thr Ala Cys Thr Gly Cys Cys Gly 
    210                 215                 220                 


Gly Thr Gly Cys Ala Ala Cys Ala Gly Cys Gly Gly Cys Cys Thr Gly 
225                 230                 235                 240 


Gly Cys Ala Cys Ala Gly Thr Gly Cys Cys Ala Cys Thr Cys Gly Gly 
                245                 250                 255     


Thr Gly Cys Cys Cys Gly Thr Cys Cys Gly Ala Ala Gly Thr Thr Gly 
            260                 265                 270         


Cys Ala Gly Thr Gly Ala Ala Cys Cys Gly Ala Gly Ala Thr Gly Cys 
        275                 280                 285             


Thr Thr Cys Ala Ala Thr Gly Gly Gly Gly Gly Thr Ala Cys Gly Thr 
    290                 295                 300                 


Gly Thr Cys Ala Gly Cys Ala Gly Gly Cys Cys Cys Thr Gly Thr Ala 
305                 310                 315                 320 


Thr Thr Thr Cys Thr Cys Thr Gly Ala Cys Thr Thr Cys Gly Thr Cys 
                325                 330                 335     


Thr Gly Cys Cys Ala Gly Thr Gly Cys Cys Cys Thr Gly Ala Cys Gly 
            340                 345                 350         


Gly Ala Thr Thr Thr Gly Thr Thr Gly Gly Gly Ala Ala Ala Cys Gly 
        355                 360                 365             


Cys Thr Gly Thr Gly Ala Thr Ala Thr Ala Gly Ala Thr Ala Cys Cys 
    370                 375                 380                 


Ala Gly Ala Gly Cys Ala Ala Cys Cys Thr Gly Cys Thr Thr Cys Gly 
385                 390                 395                 400 


Ala Gly Gly Gly Cys Cys Ala Gly Gly Gly Cys Ala Thr Cys Ala Cys 
                405                 410                 415     


Cys Thr Ala Cys Ala Gly Ala Gly Gly Cys Ala Cys Ala Thr Gly Gly 
            420                 425                 430         


Ala Gly Cys Ala Cys Ala Gly Cys Ala Gly Ala Ala Ala Ala Thr Gly 
        435                 440                 445             


Gly Gly Gly Cys Thr Gly Ala Ala Thr Gly Cys Ala Thr Cys Ala Ala 
    450                 455                 460                 


Cys Thr Gly Gly Ala Ala Thr Ala Gly Cys Ala Gly Thr Gly Cys Cys 
465                 470                 475                 480 


Cys Thr Gly Thr Cys Cys Cys Ala Gly Ala Ala Gly Cys Cys Cys Thr 
                485                 490                 495     


Ala Cys Ala Gly Thr Gly Cys Ala Ala Gly Gly Ala Gly Gly Cys Cys 
            500                 505                 510         


Ala Ala Ala Thr Gly Cys Cys Ala Thr Cys Ala Ala Gly Cys Thr Gly 
        515                 520                 525             


Gly Gly Cys Cys Thr Thr Gly Gly Gly Ala Ala Cys Cys Ala Cys Ala 
    530                 535                 540                 


Ala Thr Thr Ala Cys Thr Gly Cys Ala Gly Ala Ala Ala Cys Cys Cys 
545                 550                 555                 560 


Ala Gly Ala Cys Cys Gly Ala Gly Ala Cys Gly Thr Gly Ala Gly Gly 
                565                 570                 575     


Cys Cys Cys Thr Gly Gly Thr Gly Cys Thr Ala Thr Gly Thr Cys Thr 
            580                 585                 590         


Thr Thr Ala Ala Gly Gly Cys Ala Gly Gly Gly Ala Ala Gly Thr Ala 
        595                 600                 605             


Thr Ala Cys Cys Ala Cys Gly Gly Ala Gly Thr Thr Cys Thr Gly Cys 
    610                 615                 620                 


Ala Gly Cys Ala Cys Gly Cys Cys Gly Gly Cys Thr Thr Gly Cys Cys 
625                 630                 635                 640 


Cys Thr Ala Ala Gly Gly Gly Ala Cys Cys Ala Ala Cys Thr Gly Ala 
                645                 650                 655     


Gly Gly Ala Cys Thr Gly Cys Thr Ala Thr Gly Thr Thr Gly Gly Ala 
            660                 665                 670         


Ala Ala Ala Gly Gly Thr Gly Thr Gly Ala Cys Thr Thr Ala Cys Cys 
        675                 680                 685             


Gly Thr Gly Gly Cys Ala Cys Cys Cys Ala Cys Ala Gly Cys Thr Thr 
    690                 695                 700                 


Thr Ala Cys Cys Ala Cys Ala Thr Cys Cys Ala Ala Gly Gly Cys Cys 
705                 710                 715                 720 


Thr Cys Cys Thr Gly Cys Cys Thr Cys Cys Cys Ala Thr Gly Gly Ala 
                725                 730                 735     


Ala Thr Thr Cys Cys Ala Thr Gly Ala Thr Cys Cys Thr Gly Ala Thr 
            740                 745                 750         


Ala Gly Gly Cys Ala Ala Gly Ala Cys Thr Thr Ala Cys Ala Cys Ala 
        755                 760                 765             


Gly Cys Gly Thr Gly Gly Ala Gly Gly Gly Cys Cys Ala Ala Cys Thr 
    770                 775                 780                 


Cys Cys Cys Ala Gly Gly Cys Ala Cys Thr Thr Gly Gly Cys Cys Thr 
785                 790                 795                 800 


Gly Gly Gly Cys Ala Gly Ala Cys Ala Cys Ala Ala Thr Thr Ala Thr 
                805                 810                 815     


Thr Gly Cys Cys Gly Gly Ala Ala Cys Cys Cys Ala Gly Ala Thr Gly 
            820                 825                 830         


Gly Gly Gly Ala Thr Gly Cys Cys Ala Ala Ala Cys Cys Thr Thr Gly 
        835                 840                 845             


Gly Thr Gly Cys Cys Ala Cys Gly Thr Gly Ala Thr Gly Ala Ala Gly 
    850                 855                 860                 


Gly Ala Cys Cys Gly Ala Ala Ala Gly Cys Thr Gly Ala Cys Ala Thr 
865                 870                 875                 880 


Gly Gly Gly Ala Ala Thr Ala Thr Thr Gly Cys Gly Ala Cys Ala Thr 
                885                 890                 895     


Gly Thr Cys Cys Cys Cys Ala Thr Gly Cys Thr Cys Cys Ala Cys Cys 
            900                 905                 910         


Thr Gly Cys Gly Gly Cys Cys Thr Gly Ala Gly Gly Cys Ala Ala Thr 
        915                 920                 925             


Ala Cys Ala Ala Ala Cys Ala Gly Cys Cys Thr Cys Thr Gly Thr Thr 
    930                 935                 940                 


Thr Cys Gly Ala Ala Thr Thr Ala Ala Ala Gly Gly Ala Gly Gly Ala 
945                 950                 955                 960 


Cys Thr Cys Thr Thr Cys Ala Cys Ala Gly Ala Cys Ala Thr Cys Ala 
                965                 970                 975     


Cys Cys Thr Cys Ala Cys Ala Cys Cys Cys Thr Thr Gly Gly Cys Ala 
            980                 985                 990         


Gly Gly Cys Cys Gly Cys Cys Ala  Thr Cys Thr Thr Thr  Gly Thr Cys 
        995                 1000                 1005             


Ala Ala  Gly Ala Ala Cys Ala  Ala Gly Ala Gly Gly  Thr Cys Thr 
    1010                 1015                 1020             


Cys Cys  Ala Gly Gly Ala Gly  Ala Gly Ala Gly Ala  Thr Thr Cys 
    1025                 1030                 1035             


Cys Thr  Gly Thr Gly Thr Gly  Gly Ala Gly Gly Gly  Gly Thr Gly 
    1040                 1045                 1050             


Cys Thr  Gly Ala Thr Cys Ala  Gly Thr Thr Cys Cys  Thr Gly Cys 
    1055                 1060                 1065             


Thr Gly  Gly Gly Thr Gly Cys  Thr Ala Thr Cys Thr  Gly Cys Cys 
    1070                 1075                 1080             


Gly Cys  Cys Cys Ala Cys Thr  Gly Cys Thr Thr Thr  Gly Thr Ala 
    1085                 1090                 1095             


Gly Ala  Gly Ala Gly Gly Thr  Thr Thr Cys Cys Ala  Cys Cys Cys 
    1100                 1105                 1110             


Cys Ala  Thr Cys Ala Thr Cys  Thr Thr Ala Ala Ala  Gly Thr Gly 
    1115                 1120                 1125             


Gly Thr  Cys Thr Thr Gly Gly  Gly Cys Ala Gly Ala  Ala Cys Ala 
    1130                 1135                 1140             


Thr Ala  Cys Ala Gly Ala Gly  Thr Gly Gly Thr Cys  Cys Cys Thr 
    1145                 1150                 1155             


Gly Gly  Ala Gly Ala Gly Gly  Ala Gly Gly Ala Gly  Cys Ala Gly 
    1160                 1165                 1170             


Ala Cys  Ala Thr Thr Cys Gly  Ala Gly Ala Thr Cys  Gly Ala Ala 
    1175                 1180                 1185             


Ala Ala  Gly Thr Ala Cys Ala  Thr Ala Gly Thr Cys  Cys Ala Thr 
    1190                 1195                 1200             


Ala Ala  Gly Gly Ala Ala Thr  Thr Thr Gly Ala Thr  Gly Ala Cys 
    1205                 1210                 1215             


Gly Ala  Cys Ala Cys Thr Thr  Ala Thr Gly Ala Cys  Ala Ala Thr 
    1220                 1225                 1230             


Gly Ala  Cys Ala Thr Cys Gly  Cys Ala Thr Thr Ala  Cys Thr Gly 
    1235                 1240                 1245             


Cys Ala  Gly Cys Thr Gly Ala  Gly Gly Thr Cys Ala  Gly Ala Thr 
    1250                 1255                 1260             


Thr Cys  Cys Ala Gly Thr Cys  Ala Gly Thr Gly Thr  Gly Cys Cys 
    1265                 1270                 1275             


Cys Ala  Gly Gly Ala Gly Ala  Gly Cys Ala Gly Thr  Thr Cys Thr 
    1280                 1285                 1290             


Gly Thr  Cys Gly Gly Cys Ala  Cys Thr Gly Cys Cys  Thr Gly Cys 
    1295                 1300                 1305             


Cys Thr  Cys Cys Cys Thr Gly  Ala Cys Cys Cys Cys  Gly Ala Cys 
    1310                 1315                 1320             


Gly Thr  Ala Cys Ala Gly Cys  Thr Thr Cys Cys Thr  Gly Ala Cys 
    1325                 1330                 1335             


Thr Gly  Gly Ala Cys Ala Gly  Ala Gly Thr Gly Thr  Gly Ala Gly 
    1340                 1345                 1350             


Cys Thr  Thr Thr Cys Thr Gly  Gly Cys Thr Ala Cys  Gly Gly Cys 
    1355                 1360                 1365             


Ala Ala  Gly Cys Ala Thr Gly  Ala Gly Gly Cys Ala  Thr Cys Cys 
    1370                 1375                 1380             


Thr Cys  Thr Cys Cys Thr Thr  Thr Cys Thr Thr Cys  Thr Cys Thr 
    1385                 1390                 1395             


Gly Ala  Cys Cys Gly Gly Cys  Thr Gly Ala Ala Gly  Gly Ala Gly 
    1400                 1405                 1410             


Gly Cys  Thr Cys Ala Cys Gly  Thr Cys Ala Gly Ala  Cys Thr Gly 
    1415                 1420                 1425             


Thr Ala  Thr Cys Cys Gly Thr  Cys Cys Ala Gly Cys  Cys Gly Cys 
    1430                 1435                 1440             


Thr Gly  Thr Ala Cys Cys Thr  Cys Ala Cys Ala Gly  Cys Ala Thr 
    1445                 1450                 1455             


Cys Thr  Gly Thr Thr Thr Ala  Ala Cys Ala Ala Ala  Ala Cys Cys 
    1460                 1465                 1470             


Ala Thr  Cys Ala Cys Gly Ala  Gly Cys Ala Ala Cys  Ala Thr Gly 
    1475                 1480                 1485             


Cys Thr  Gly Thr Gly Thr Gly  Cys Ala Gly Gly Ala  Gly Ala Cys 
    1490                 1495                 1500             


Ala Cys  Cys Cys Gly Ala Ala  Cys Thr Gly Gly Gly  Gly Gly Cys 
    1505                 1510                 1515             


Ala Ala  Cys Cys Ala Ala Gly  Ala Cys Gly Thr Cys  Cys Ala Thr 
    1520                 1525                 1530             


Gly Ala  Cys Gly Cys Gly Thr  Gly Cys Cys Ala Gly  Gly Gly Thr 
    1535                 1540                 1545             


Gly Ala  Cys Thr Cys Ala Gly  Gly Ala Gly Gly Cys  Cys Cys Thr 
    1550                 1555                 1560             


Cys Thr  Gly Gly Thr Gly Thr  Gly Cys Ala Thr Gly  Ala Thr Cys 
    1565                 1570                 1575             


Gly Ala  Thr Ala Ala Gly Cys  Gly Gly Ala Thr Gly  Ala Cys Thr 
    1580                 1585                 1590             


Thr Thr  Ala Cys Thr Gly Gly  Gly Cys Ala Thr Cys  Ala Thr Cys 
    1595                 1600                 1605             


Ala Gly  Cys Thr Gly Gly Gly  Gly Cys Cys Thr Cys  Gly Gly Cys 
    1610                 1615                 1620             


Thr Gly  Thr Gly Gly Gly Cys  Ala Gly Ala Ala Gly  Gly Ala Cys 
    1625                 1630                 1635             


Gly Thr  Gly Cys Cys Ala Gly  Gly Gly Ala Thr Ala  Thr Ala Cys 
    1640                 1645                 1650             


Ala Cys  Ala Ala Ala Gly Gly  Thr Cys Ala Cys Thr  Ala Ala Thr 
    1655                 1660                 1665             


Thr Ala  Cys Cys Thr Gly Ala  Ala Cys Thr Gly Gly  Ala Thr Thr 
    1670                 1675                 1680             


Cys Ala  Ala Gly Ala Cys Ala  Ala Cys Ala Thr Gly  Ala Ala Gly 
    1685                 1690                 1695             


Cys Ala  Ala Ala Ala Gly Cys  Thr Thr Ala Ala Thr  Thr Ala Gly 
    1700                 1705                 1710             


Cys Thr  Gly Ala Gly Cys Thr  Thr Gly Gly Ala Cys  Thr Cys Cys 
    1715                 1720                 1725             


Thr Gly  Thr Thr Gly Ala 
    1730                 


<210>  16
<211>  1614
<212>  PRT
<213>  Rattus norvegicus

<400>  16

Thr Cys Cys Thr Ala Cys Ala Gly Ala Gly Cys Gly Ala Cys Cys Thr 
1               5                   10                  15      


Gly Cys Ala Gly Ala Gly Ala Thr Gly Ala Ala Cys Ala Gly Ala Cys 
            20                  25                  30          


Thr Cys Ala Gly Ala Cys Ala Ala Cys Thr Thr Ala Cys Cys Ala Ala 
        35                  40                  45              


Cys Ala Gly Cys Ala Thr Cys Ala Gly Thr Cys Ala Thr Gly Gly Cys 
    50                  55                  60                  


Thr Ala Cys Gly Thr Cys Cys Cys Ala Thr Gly Cys Thr Cys Ala Gly 
65                  70                  75                  80  


Ala Gly Gly Cys Ala Ala Thr Cys Gly Gly Gly Thr Gly Gly Ala Ala 
                85                  90                  95      


Thr Ala Cys Thr Gly Cys Cys Gly Gly Thr Gly Cys Ala Ala Cys Ala 
            100                 105                 110         


Gly Cys Gly Gly Cys Cys Thr Gly Gly Cys Ala Cys Ala Gly Thr Gly 
        115                 120                 125             


Cys Cys Ala Cys Thr Cys Gly Gly Thr Gly Cys Cys Cys Gly Thr Cys 
    130                 135                 140                 


Cys Gly Ala Ala Gly Thr Thr Gly Cys Ala Gly Thr Gly Ala Ala Cys 
145                 150                 155                 160 


Cys Gly Ala Gly Ala Thr Gly Cys Thr Thr Cys Ala Ala Thr Gly Gly 
                165                 170                 175     


Gly Gly Gly Thr Ala Cys Gly Thr Gly Thr Cys Ala Gly Cys Ala Gly 
            180                 185                 190         


Gly Cys Cys Cys Thr Gly Thr Ala Thr Thr Thr Cys Thr Cys Thr Gly 
        195                 200                 205             


Ala Cys Thr Thr Cys Gly Thr Cys Thr Gly Cys Cys Ala Gly Thr Gly 
    210                 215                 220                 


Cys Cys Cys Thr Gly Ala Cys Gly Gly Ala Thr Thr Thr Gly Thr Thr 
225                 230                 235                 240 


Gly Gly Gly Ala Ala Ala Cys Gly Cys Thr Gly Thr Gly Ala Thr Ala 
                245                 250                 255     


Thr Ala Gly Ala Thr Ala Cys Cys Ala Gly Ala Gly Cys Ala Ala Cys 
            260                 265                 270         


Cys Thr Gly Cys Thr Thr Cys Gly Ala Gly Gly Gly Cys Cys Ala Gly 
        275                 280                 285             


Gly Gly Cys Ala Thr Cys Ala Cys Cys Thr Ala Cys Ala Gly Ala Gly 
    290                 295                 300                 


Gly Cys Ala Cys Ala Thr Gly Gly Ala Gly Cys Ala Cys Ala Gly Cys 
305                 310                 315                 320 


Ala Gly Ala Ala Ala Ala Thr Gly Gly Gly Gly Cys Thr Gly Ala Ala 
                325                 330                 335     


Thr Gly Cys Ala Thr Cys Ala Ala Cys Thr Gly Gly Ala Ala Thr Ala 
            340                 345                 350         


Gly Cys Ala Gly Thr Gly Cys Cys Cys Thr Gly Thr Cys Cys Cys Ala 
        355                 360                 365             


Gly Ala Ala Gly Cys Cys Cys Thr Ala Cys Ala Gly Thr Gly Cys Ala 
    370                 375                 380                 


Ala Gly Gly Ala Gly Gly Cys Cys Ala Ala Ala Thr Gly Cys Cys Ala 
385                 390                 395                 400 


Thr Cys Ala Ala Gly Cys Thr Gly Gly Gly Cys Cys Thr Thr Gly Gly 
                405                 410                 415     


Gly Ala Ala Cys Cys Ala Cys Ala Ala Thr Thr Ala Cys Thr Gly Cys 
            420                 425                 430         


Ala Gly Ala Ala Ala Cys Cys Cys Ala Gly Ala Cys Cys Gly Ala Gly 
        435                 440                 445             


Ala Cys Gly Thr Gly Ala Gly Gly Cys Cys Cys Thr Gly Gly Thr Gly 
    450                 455                 460                 


Cys Thr Ala Thr Gly Thr Cys Thr Thr Thr Ala Ala Gly Gly Cys Ala 
465                 470                 475                 480 


Gly Gly Gly Ala Ala Gly Thr Ala Thr Ala Cys Cys Ala Cys Gly Gly 
                485                 490                 495     


Ala Gly Thr Thr Cys Thr Gly Cys Ala Gly Cys Ala Cys Gly Cys Cys 
            500                 505                 510         


Gly Gly Cys Thr Thr Gly Cys Cys Cys Thr Ala Ala Gly Gly Gly Ala 
        515                 520                 525             


Cys Cys Ala Ala Cys Thr Gly Ala Gly Gly Ala Cys Thr Gly Cys Thr 
    530                 535                 540                 


Ala Thr Gly Thr Thr Gly Gly Ala Ala Ala Ala Gly Gly Thr Gly Thr 
545                 550                 555                 560 


Gly Ala Cys Thr Thr Ala Cys Cys Gly Thr Gly Gly Cys Ala Cys Cys 
                565                 570                 575     


Cys Ala Cys Ala Gly Cys Thr Thr Thr Ala Cys Cys Ala Cys Ala Thr 
            580                 585                 590         


Cys Cys Ala Ala Gly Gly Cys Cys Thr Cys Cys Thr Gly Cys Cys Thr 
        595                 600                 605             


Cys Cys Cys Ala Thr Gly Gly Ala Ala Thr Thr Cys Cys Ala Thr Gly 
    610                 615                 620                 


Ala Thr Cys Cys Thr Gly Ala Thr Ala Gly Gly Cys Ala Ala Gly Ala 
625                 630                 635                 640 


Cys Thr Thr Ala Cys Ala Cys Ala Gly Cys Gly Thr Gly Gly Ala Gly 
                645                 650                 655     


Gly Gly Cys Cys Ala Ala Cys Thr Cys Cys Cys Ala Gly Gly Cys Ala 
            660                 665                 670         


Cys Thr Thr Gly Gly Cys Cys Thr Gly Gly Gly Cys Ala Gly Ala Cys 
        675                 680                 685             


Ala Cys Ala Ala Thr Thr Ala Thr Thr Gly Cys Cys Gly Gly Ala Ala 
    690                 695                 700                 


Cys Cys Cys Ala Gly Ala Thr Gly Gly Gly Gly Ala Thr Gly Cys Cys 
705                 710                 715                 720 


Ala Ala Ala Cys Cys Thr Thr Gly Gly Thr Gly Cys Cys Ala Cys Gly 
                725                 730                 735     


Thr Gly Ala Thr Gly Ala Ala Gly Gly Ala Cys Cys Gly Ala Ala Ala 
            740                 745                 750         


Gly Cys Thr Gly Ala Cys Ala Thr Gly Gly Gly Ala Ala Thr Ala Thr 
        755                 760                 765             


Thr Gly Cys Gly Ala Cys Ala Thr Gly Thr Cys Cys Cys Cys Ala Thr 
    770                 775                 780                 


Gly Cys Thr Cys Cys Ala Cys Cys Thr Gly Cys Gly Gly Cys Cys Thr 
785                 790                 795                 800 


Gly Ala Gly Gly Cys Ala Ala Thr Ala Cys Ala Ala Ala Cys Ala Gly 
                805                 810                 815     


Cys Cys Thr Cys Thr Gly Thr Thr Thr Cys Gly Ala Ala Thr Thr Ala 
            820                 825                 830         


Ala Ala Gly Gly Ala Gly Gly Ala Cys Thr Cys Thr Thr Cys Ala Cys 
        835                 840                 845             


Ala Gly Ala Cys Ala Thr Cys Ala Cys Cys Thr Cys Ala Cys Ala Cys 
    850                 855                 860                 


Cys Cys Thr Thr Gly Gly Cys Ala Gly Gly Cys Cys Gly Cys Cys Ala 
865                 870                 875                 880 


Thr Cys Thr Thr Thr Gly Thr Cys Ala Ala Gly Ala Ala Cys Ala Ala 
                885                 890                 895     


Gly Ala Gly Gly Thr Cys Thr Cys Cys Ala Gly Gly Ala Gly Ala Gly 
            900                 905                 910         


Ala Gly Ala Thr Thr Cys Cys Thr Gly Thr Gly Thr Gly Gly Ala Gly 
        915                 920                 925             


Gly Gly Gly Thr Gly Cys Thr Gly Ala Thr Cys Ala Gly Thr Thr Cys 
    930                 935                 940                 


Cys Thr Gly Cys Thr Gly Gly Gly Thr Gly Cys Thr Ala Thr Cys Thr 
945                 950                 955                 960 


Gly Cys Cys Gly Cys Cys Cys Ala Cys Thr Gly Cys Thr Thr Thr Gly 
                965                 970                 975     


Thr Ala Gly Ala Gly Ala Gly Gly Thr Thr Thr Cys Cys Ala Cys Cys 
            980                 985                 990         


Cys Cys Ala Thr Cys Ala Thr Cys  Thr Thr Ala Ala Ala  Gly Thr Gly 
        995                 1000                 1005             


Gly Thr  Cys Thr Thr Gly Gly  Gly Cys Ala Gly Ala  Ala Cys Ala 
    1010                 1015                 1020             


Thr Ala  Cys Ala Gly Ala Gly  Thr Gly Gly Thr Cys  Cys Cys Thr 
    1025                 1030                 1035             


Gly Gly  Ala Gly Ala Gly Gly  Ala Gly Gly Ala Gly  Cys Ala Gly 
    1040                 1045                 1050             


Ala Cys  Ala Thr Thr Cys Gly  Ala Gly Ala Thr Cys  Gly Ala Ala 
    1055                 1060                 1065             


Ala Ala  Gly Thr Ala Cys Ala  Thr Ala Gly Thr Cys  Cys Ala Thr 
    1070                 1075                 1080             


Ala Ala  Gly Gly Ala Ala Thr  Thr Thr Gly Ala Thr  Gly Ala Cys 
    1085                 1090                 1095             


Gly Ala  Cys Ala Cys Thr Thr  Ala Thr Gly Ala Cys  Ala Ala Thr 
    1100                 1105                 1110             


Gly Ala  Cys Ala Thr Cys Gly  Cys Ala Thr Thr Ala  Cys Thr Gly 
    1115                 1120                 1125             


Cys Ala  Gly Cys Thr Gly Ala  Gly Gly Thr Cys Ala  Gly Ala Thr 
    1130                 1135                 1140             


Thr Cys  Cys Ala Gly Thr Cys  Ala Gly Thr Gly Thr  Gly Cys Cys 
    1145                 1150                 1155             


Cys Ala  Gly Gly Ala Gly Ala  Gly Cys Ala Gly Thr  Thr Cys Thr 
    1160                 1165                 1170             


Gly Thr  Cys Gly Gly Cys Ala  Cys Thr Gly Cys Cys  Thr Gly Cys 
    1175                 1180                 1185             


Cys Thr  Cys Cys Cys Thr Gly  Ala Cys Cys Cys Cys  Gly Ala Cys 
    1190                 1195                 1200             


Gly Thr  Ala Cys Ala Gly Cys  Thr Thr Cys Cys Thr  Gly Ala Cys 
    1205                 1210                 1215             


Thr Gly  Gly Ala Cys Ala Gly  Ala Gly Thr Gly Thr  Gly Ala Gly 
    1220                 1225                 1230             


Cys Thr  Thr Thr Cys Thr Gly  Gly Cys Thr Ala Cys  Gly Gly Cys 
    1235                 1240                 1245             


Ala Ala  Gly Cys Ala Thr Gly  Ala Gly Gly Cys Ala  Thr Cys Cys 
    1250                 1255                 1260             


Thr Cys  Thr Cys Cys Thr Thr  Thr Cys Thr Thr Cys  Thr Cys Thr 
    1265                 1270                 1275             


Gly Ala  Cys Cys Gly Gly Cys  Thr Gly Ala Ala Gly  Gly Ala Gly 
    1280                 1285                 1290             


Gly Cys  Thr Cys Ala Cys Gly  Thr Cys Ala Gly Ala  Cys Thr Gly 
    1295                 1300                 1305             


Thr Ala  Thr Cys Cys Gly Thr  Cys Cys Ala Gly Cys  Cys Gly Cys 
    1310                 1315                 1320             


Thr Gly  Thr Ala Cys Cys Thr  Cys Ala Cys Ala Gly  Cys Ala Thr 
    1325                 1330                 1335             


Cys Thr  Gly Thr Thr Thr Ala  Ala Cys Ala Ala Ala  Ala Cys Cys 
    1340                 1345                 1350             


Ala Thr  Cys Ala Cys Gly Ala  Gly Cys Ala Ala Cys  Ala Thr Gly 
    1355                 1360                 1365             


Cys Thr  Gly Thr Gly Thr Gly  Cys Ala Gly Gly Ala  Gly Ala Cys 
    1370                 1375                 1380             


Ala Cys  Cys Cys Gly Ala Ala  Cys Thr Gly Gly Gly  Gly Gly Cys 
    1385                 1390                 1395             


Ala Ala  Cys Cys Ala Ala Gly  Ala Cys Gly Thr Cys  Cys Ala Thr 
    1400                 1405                 1410             


Gly Ala  Cys Gly Cys Gly Thr  Gly Cys Cys Ala Gly  Gly Gly Thr 
    1415                 1420                 1425             


Gly Ala  Cys Thr Cys Ala Gly  Gly Ala Gly Gly Cys  Cys Cys Thr 
    1430                 1435                 1440             


Cys Thr  Gly Gly Thr Gly Thr  Gly Cys Ala Thr Gly  Ala Thr Cys 
    1445                 1450                 1455             


Gly Ala  Thr Ala Ala Gly Cys  Gly Gly Ala Thr Gly  Ala Cys Thr 
    1460                 1465                 1470             


Thr Thr  Ala Cys Thr Gly Gly  Gly Cys Ala Thr Cys  Ala Thr Cys 
    1475                 1480                 1485             


Ala Gly  Cys Thr Gly Gly Gly  Gly Cys Cys Thr Cys  Gly Gly Cys 
    1490                 1495                 1500             


Thr Gly  Thr Gly Gly Gly Cys  Ala Gly Ala Ala Gly  Gly Ala Cys 
    1505                 1510                 1515             


Gly Thr  Gly Cys Cys Ala Gly  Gly Gly Ala Thr Ala  Thr Ala Cys 
    1520                 1525                 1530             


Ala Cys  Ala Ala Ala Gly Gly  Thr Cys Ala Cys Thr  Ala Ala Thr 
    1535                 1540                 1545             


Thr Ala  Cys Cys Thr Gly Ala  Ala Cys Thr Gly Gly  Ala Thr Thr 
    1550                 1555                 1560             


Cys Ala  Ala Gly Ala Cys Ala  Ala Cys Ala Thr Gly  Ala Ala Gly 
    1565                 1570                 1575             


Cys Ala  Ala Ala Ala Gly Cys  Thr Thr Ala Ala Thr  Thr Ala Gly 
    1580                 1585                 1590             


Cys Thr  Gly Ala Gly Cys Thr  Thr Gly Gly Ala Cys  Thr Cys Cys 
    1595                 1600                 1605             


Thr Gly  Thr Thr Gly Ala 
    1610                 


<210>  17
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  17
ccgggatcct cctacagagc gacc                                              24


<210>  18
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  18
ggcaagcttt tgcttcatgt tgtcttgaat ccagtt                                 36


<210>  19
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  19
caggccgcac gtggagtcct gagttggtcc cttagg                                 36


<210>  20
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  20
tccacctgcg gcctg                                                        15


<210>  21
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  21
ggaccgaaag ctgacacggg aatattgcga catgtcc                                37


<210>  22
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  22
ggacatgtcg caatattccc gtggtcagct ttcggtcc                               38


<210>  23
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  23
tacaaacagc ctctgtttcg aattaaagga gga                                    33


<210>  24
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  24
tcctccttta attcgaaaca gaggctgttt gta                                    33


<210>  25
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  25

Ser Tyr Gln Val Ile Cys Arg Asp Glu Lys Thr Gln Met Ile Tyr Gln 
1               5                   10                  15      


Gln His Gln Ser Trp Leu Arg Pro Val Leu Arg Ser Asn Arg Val Glu 
            20                  25                  30          


Tyr Cys Trp Cys Asn Ser Gly Arg Ala Gln Cys His Ser Val Pro Val 
        35                  40                  45              


Lys Ser Cys Ser Glu Pro Arg Cys Phe Asn Gly Gly Thr Cys Gln Gln 
    50                  55                  60                  


Ala Leu Tyr Phe Ser Asp Phe Val Cys Gln Cys Pro Glu Gly Phe Ala 
65                  70                  75                  80  


Gly Lys Cys Cys Glu Ile Asp Thr Arg Ala Thr Cys Tyr Glu Asp Gln 
                85                  90                  95      


Gly Ile Ser Tyr Arg Gly Thr Trp Ser Thr Ala Glu Ser Gly Ala Glu 
            100                 105                 110         


Cys Thr Asn Trp Asn Ser Ser Ala Leu Ala Gln Lys Pro Tyr Ser Gly 
        115                 120                 125             


Arg Arg Pro Asp Ala Ile Arg Leu Gly Leu Gly Asn His Asn Tyr Cys 
    130                 135                 140                 


Arg Asn Pro Asp Arg Asp Ser Lys Pro Trp Cys Tyr Val Phe Lys Ala 
145                 150                 155                 160 


Gly Lys Tyr Ser Ser Glu Phe Cys Ser Thr Pro Ala Cys Ser Glu Gly 
                165                 170                 175     


Asn Ser Asp Cys Tyr Phe Gly Asn Gly Ser Ala Tyr Arg Gly Thr His 
            180                 185                 190         


Ser Leu Thr Glu Ser Gly Ala Ser Cys Leu Pro Trp Asn Ser Met Ile 
        195                 200                 205             


Leu Ile Gly Lys Val Tyr Thr Ala Gln Asn Pro Ser Ala Gln Ala Leu 
    210                 215                 220                 


Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Gly Asp Ala Lys 
225                 230                 235                 240 


Pro Trp Cys His Val Leu Lys Asn Arg Arg Leu Thr Trp Glu Tyr Cys 
                245                 250                 255     


Asp Val Pro Ser Cys Ser Thr Cys Gly Leu Arg Gln Tyr Ser Gln Pro 
            260                 265                 270         


Gln Phe Arg 
        275 


<210>  26
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  26

Ile Lys Gly Gly Leu Phe Ala Asp Ile Ala Ser His Pro Trp Gln Ala 
1               5                   10                  15      


Ala Ile Phe Ala Lys His Arg Arg Ser Pro Gly Glu Arg Phe Leu Cys 
            20                  25                  30          


Gly Gly Ile Leu Ile Ser Ser Cys Trp Ile Leu Ser Ala Ala His Cys 
        35                  40                  45              


Phe Gln Glu Arg Phe Pro Pro His His Leu Thr Val Ile Leu Gly Arg 
    50                  55                  60                  


Thr Tyr Arg Val Val Pro Gly Glu Glu Glu Gln Lys Phe Glu Val Glu 
65                  70                  75                  80  


Lys Tyr Ile Val His Lys Glu Phe Asp Asp Asp Thr Tyr Asp Asn Asp 
                85                  90                  95      


Ile Ala Leu Leu Gln Leu Lys Ser Asp Ser Ser Arg Cys Ala Gln Glu 
            100                 105                 110         


Ser Ser Val Val Arg Thr Val Cys Leu Pro Pro Ala Asp Leu Gln Leu 
        115                 120                 125             


Pro Asp Trp Thr Glu Cys Glu Leu Ser Gly Tyr Gly Lys His Glu Ala 
    130                 135                 140                 


Leu Ser Pro Phe Tyr Ser Glu Arg Leu Lys Glu Ala His Val Arg Leu 
145                 150                 155                 160 


Tyr Pro Ser Ser Arg Cys Thr Ser Gln His Leu Leu Asn Arg Thr Val 
                165                 170                 175     


Thr Asp Asn Met Leu Cys Ala Gly Asp Thr Arg Ser Gly Gly Pro Gln 
            180                 185                 190         


Ala Asn Leu His Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val 
        195                 200                 205             


Cys Leu Asn Asp Gly Arg Met Thr Leu Val Gly Ile Ile Ser Trp Gly 
    210                 215                 220                 


Leu Gly Cys Gly Gln Lys Asp Val Pro Gly Val Tyr Thr Lys Val Thr 
225                 230                 235                 240 


Asn Tyr Leu Asp Trp Ile Arg Asp Asn Met Arg Pro 
                245                 250         


<210>  27
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  his tPA

<400>  27

His His His His His His Gly Ser Ser Tyr Gln Val Ile Cys Arg Asp 
1               5                   10                  15      


Glu Lys Thr Gln Met Ile Tyr Gln Gln His Gln Ser Trp Leu Arg Pro 
            20                  25                  30          


Val Leu Arg Ser Asn Arg Val Glu Tyr Cys Trp Cys Asn Ser Gly Arg 
        35                  40                  45              


Ala Gln Cys His Ser Val Pro Val Lys Ser Cys Ser Glu Pro Arg Cys 
    50                  55                  60                  


Phe Asn Gly Gly Thr Cys Gln Gln Ala Leu Tyr Phe Ser Asp Phe Val 
65                  70                  75                  80  


Cys Gln Cys Pro Glu Gly Phe Ala Gly Lys Cys Cys Glu Ile Asp Thr 
                85                  90                  95      


Arg Ala Thr Cys Tyr Glu Asp Gln Gly Ile Ser Tyr Arg Gly Thr Trp 
            100                 105                 110         


Ser Thr Ala Glu Ser Gly Ala Glu Cys Thr Asn Trp Asn Ser Ser Ala 
        115                 120                 125             


Leu Ala Gln Lys Pro Tyr Ser Gly Arg Arg Pro Asp Ala Ile Arg Leu 
    130                 135                 140                 


Gly Leu Gly Asn His Asn Tyr Cys Arg Asn Pro Asp Arg Asp Ser Lys 
145                 150                 155                 160 


Pro Trp Cys Tyr Val Phe Lys Ala Gly Lys Tyr Ser Ser Glu Phe Cys 
                165                 170                 175     


Ser Thr Pro Ala Cys Ser Glu Gly Asn Ser Asp Cys Tyr Phe Gly Asn 
            180                 185                 190         


Gly Ser Ala Tyr Arg Gly Thr His Ser Leu Thr Glu Ser Gly Ala Ser 
        195                 200                 205             


Cys Leu Pro Trp Asn Ser Met Ile Leu Ile Gly Lys Val Tyr Thr Ala 
    210                 215                 220                 


Gln Asn Pro Ser Ala Gln Ala Leu Gly Leu Gly Lys His Asn Tyr Cys 
225                 230                 235                 240 


Arg Asn Pro Asp Gly Asp Ala Lys Pro Trp Cys His Val Leu Lys Asn 
                245                 250                 255     


Arg Arg Leu Thr Trp Glu Tyr Cys Asp Val Pro Ser Cys Ser Thr Cys 
            260                 265                 270         


Gly Leu Arg Gln Tyr Ser Gln Pro Gln Phe Arg Ile Lys Gly Gly Leu 
        275                 280                 285             


Phe Ala Asp Ile Ala Ser His Pro Trp Gln Ala Ala Ile Phe Ala Lys 
    290                 295                 300                 


His Arg Arg Ser Pro Gly Glu Arg Phe Leu Cys Gly Gly Ile Leu Ile 
305                 310                 315                 320 


Ser Ser Cys Trp Ile Leu Ser Ala Ala His Cys Phe Gln Glu Arg Phe 
                325                 330                 335     


Pro Pro His His Leu Thr Val Ile Leu Gly Arg Thr Tyr Arg Val Val 
            340                 345                 350         


Pro Gly Glu Glu Glu Gln Lys Phe Glu Val Glu Lys Tyr Ile Val His 
        355                 360                 365             


Lys Glu Phe Asp Asp Asp Thr Tyr Asp Asn Asp Ile Ala Leu Leu Gln 
    370                 375                 380                 


Leu Lys Ser Asp Ser Ser Arg Cys Ala Gln Glu Ser Ser Val Val Arg 
385                 390                 395                 400 


Thr Val Cys Leu Pro Pro Ala Asp Leu Gln Leu Pro Asp Trp Thr Glu 
                405                 410                 415     


Cys Glu Leu Ser Gly Tyr Gly Lys His Glu Ala Leu Ser Pro Phe Tyr 
            420                 425                 430         


Ser Glu Arg Leu Lys Glu Ala His Val Arg Leu Tyr Pro Ser Ser Arg 
        435                 440                 445             


Cys Thr Ser Gln His Leu Leu Asn Arg Thr Val Thr Asp Asn Met Leu 
    450                 455                 460                 


Cys Ala Gly Asp Thr Arg Ser Gly Gly Pro Gln Ala Asn Leu His Asp 
465                 470                 475                 480 


Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Leu Asn Asp Gly 
                485                 490                 495     


Arg Met Thr Leu Val Gly Ile Ile Ser Trp Gly Leu Gly Cys Gly Gln 
            500                 505                 510         


Lys Asp Val Pro Gly Val Tyr Thr Lys Val Thr Asn Tyr Leu Asp Trp 
        515                 520                 525             


Ile Arg Asp Asn Met Arg Pro 
    530                 535 


<210>  28
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  his tPA

<400>  28

His His His His His His Gly Ser Ser Tyr Gln Val Ile Cys Arg Asp 
1               5                   10                  15      


Glu Lys Thr Gln Met Ile Tyr Gln Gln His Gln Ser Trp Leu Arg Pro 
            20                  25                  30          


Val Leu Arg Ser Asn Arg Val Glu Tyr Cys Trp Cys Asn Ser Gly Arg 
        35                  40                  45              


Ala Gln Cys His Ser Val Pro Val Lys Ser Cys Ser Glu Pro Arg Cys 
    50                  55                  60                  


Phe Asn Gly Gly Thr Cys Gln Gln Ala Leu Tyr Phe Ser Asp Phe Val 
65                  70                  75                  80  


Cys Gln Cys Pro Glu Gly Phe Ala Gly Lys Cys Cys Glu Ile Asp Thr 
                85                  90                  95      


Arg Ala Thr Cys Tyr Glu Asp Gln Gly Ile Ser Tyr Arg Gly Thr Trp 
            100                 105                 110         


Ser Thr Ala Glu Ser Gly Ala Glu Cys Thr Asn Trp Asn Ser Ser Ala 
        115                 120                 125             


Leu Ala Gln Lys Pro Tyr Ser Gly Arg Arg Pro Asp Ala Ile Arg Leu 
    130                 135                 140                 


Gly Leu Gly Asn His Asn Tyr Cys Arg Asn Pro Asp Arg Asp Ser Lys 
145                 150                 155                 160 


Pro Trp Cys Tyr Val Phe Lys Ala Gly Lys Tyr Ser Ser Glu Phe Cys 
                165                 170                 175     


Ser Thr Pro Ala Cys Ser Glu Gly Asn Ser Asp Cys Tyr Phe Gly Asn 
            180                 185                 190         


Gly Ser Ala Tyr Arg Gly Thr His Ser Leu Thr Glu Ser Gly Ala Ser 
        195                 200                 205             


Cys Leu Pro Trp Asn Ser Met Ile Leu Ile Gly Lys Val Tyr Thr Ala 
    210                 215                 220                 


Gln Asn Pro Ser Ala Gln Ala Leu Gly Leu Gly Lys His Asn Tyr Cys 
225                 230                 235                 240 


Arg Asn Pro Asp Gly Asp Ala Lys Pro Trp Cys His Val Leu Lys Asn 
                245                 250                 255     


Arg Arg Leu Thr Arg Glu Tyr Cys Asp Val Pro Ser Cys Ser Thr Cys 
            260                 265                 270         


Gly Leu Arg Gln Tyr Ser Gln Pro Gln Phe Arg Ile Lys Gly Gly Leu 
        275                 280                 285             


Phe Ala Asp Ile Ala Ser His Pro Trp Gln Ala Ala Ile Phe Ala Lys 
    290                 295                 300                 


His Arg Arg Ser Pro Gly Glu Arg Phe Leu Cys Gly Gly Ile Leu Ile 
305                 310                 315                 320 


Ser Ser Cys Trp Ile Leu Ser Ala Ala His Cys Phe Gln Glu Arg Phe 
                325                 330                 335     


Pro Pro His His Leu Thr Val Ile Leu Gly Arg Thr Tyr Arg Val Val 
            340                 345                 350         


Pro Gly Glu Glu Glu Gln Lys Phe Glu Val Glu Lys Tyr Ile Val His 
        355                 360                 365             


Lys Glu Phe Asp Asp Asp Thr Tyr Asp Asn Asp Ile Ala Leu Leu Gln 
    370                 375                 380                 


Leu Lys Ser Asp Ser Ser Arg Cys Ala Gln Glu Ser Ser Val Val Arg 
385                 390                 395                 400 


Thr Val Cys Leu Pro Pro Ala Asp Leu Gln Leu Pro Asp Trp Thr Glu 
                405                 410                 415     


Cys Glu Leu Ser Gly Tyr Gly Lys His Glu Ala Leu Ser Pro Phe Tyr 
            420                 425                 430         


Ser Glu Arg Leu Lys Glu Ala His Val Arg Leu Tyr Pro Ser Ser Arg 
        435                 440                 445             


Cys Thr Ser Gln His Leu Leu Asn Arg Thr Val Thr Asp Asn Met Leu 
    450                 455                 460                 


Cys Ala Gly Asp Thr Arg Ser Gly Gly Pro Gln Ala Asn Leu His Asp 
465                 470                 475                 480 


Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Leu Asn Asp Gly 
                485                 490                 495     


Arg Met Thr Leu Val Gly Ile Ile Ser Trp Gly Leu Gly Cys Gly Gln 
            500                 505                 510         


Lys Asp Val Pro Gly Val Tyr Thr Lys Val Thr Asn Tyr Leu Asp Trp 
        515                 520                 525             


Ile Arg Asp Asn Met Arg Pro 
    530                 535 


<210>  29
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  his tPA

<400>  29

His His His His His His Gly Ser Ser Tyr Gln Val Ile Cys Arg Asp 
1               5                   10                  15      


Glu Lys Thr Gln Met Ile Tyr Gln Gln His Gln Ser Trp Leu Arg Pro 
            20                  25                  30          


Val Leu Arg Ser Asn Arg Val Glu Tyr Cys Trp Cys Asn Ser Gly Arg 
        35                  40                  45              


Ala Gln Cys His Ser Val Pro Val Lys Ser Cys Ser Glu Pro Arg Cys 
    50                  55                  60                  


Phe Asn Gly Gly Thr Cys Gln Gln Ala Leu Tyr Phe Ser Asp Phe Val 
65                  70                  75                  80  


Cys Gln Cys Pro Glu Gly Phe Ala Gly Lys Cys Cys Glu Ile Asp Thr 
                85                  90                  95      


Arg Ala Thr Cys Tyr Glu Asp Gln Gly Ile Ser Tyr Arg Gly Thr Trp 
            100                 105                 110         


Ser Thr Ala Glu Ser Gly Ala Glu Cys Thr Asn Trp Asn Ser Ser Ala 
        115                 120                 125             


Leu Ala Gln Lys Pro Tyr Ser Gly Arg Arg Pro Asp Ala Ile Arg Leu 
    130                 135                 140                 


Gly Leu Gly Asn His Asn Tyr Cys Arg Asn Pro Asp Arg Asp Ser Lys 
145                 150                 155                 160 


Pro Trp Cys Tyr Val Phe Lys Ala Gly Lys Tyr Ser Ser Glu Phe Cys 
                165                 170                 175     


Ser Thr Pro Ala Cys Ser Glu Gly Asn Ser Asp Cys Tyr Phe Gly Asn 
            180                 185                 190         


Gly Ser Ala Tyr Arg Gly Thr His Ser Leu Thr Glu Ser Gly Ala Ser 
        195                 200                 205             


Cys Leu Pro Trp Asn Ser Met Ile Leu Ile Gly Lys Val Tyr Thr Ala 
    210                 215                 220                 


Gln Asn Pro Ser Ala Gln Ala Leu Gly Leu Gly Lys His Asn Tyr Cys 
225                 230                 235                 240 


Arg Asn Pro Asp Gly Asp Ala Lys Pro Trp Cys His Val Leu Lys Asn 
                245                 250                 255     


Arg Arg Leu Thr Trp Glu Tyr Cys Asp Val Pro Ser Cys Ser Thr Cys 
            260                 265                 270         


Gly Leu Arg Gln Tyr Ser Gln Pro Gln Phe Ser Ile Lys Gly Gly Leu 
        275                 280                 285             


Phe Ala Asp Ile Ala Ser His Pro Trp Gln Ala Ala Ile Phe Ala Lys 
    290                 295                 300                 


His Arg Arg Ser Pro Gly Glu Arg Phe Leu Cys Gly Gly Ile Leu Ile 
305                 310                 315                 320 


Ser Ser Cys Trp Ile Leu Ser Ala Ala His Cys Phe Gln Glu Arg Phe 
                325                 330                 335     


Pro Pro His His Leu Thr Val Ile Leu Gly Arg Thr Tyr Arg Val Val 
            340                 345                 350         


Pro Gly Glu Glu Glu Gln Lys Phe Glu Val Glu Lys Tyr Ile Val His 
        355                 360                 365             


Lys Glu Phe Asp Asp Asp Thr Tyr Asp Asn Asp Ile Ala Leu Leu Gln 
    370                 375                 380                 


Leu Lys Ser Asp Ser Ser Arg Cys Ala Gln Glu Ser Ser Val Val Arg 
385                 390                 395                 400 


Thr Val Cys Leu Pro Pro Ala Asp Leu Gln Leu Pro Asp Trp Thr Glu 
                405                 410                 415     


Cys Glu Leu Ser Gly Tyr Gly Lys His Glu Ala Leu Ser Pro Phe Tyr 
            420                 425                 430         


Ser Glu Arg Leu Lys Glu Ala His Val Arg Leu Tyr Pro Ser Ser Arg 
        435                 440                 445             


Cys Thr Ser Gln His Leu Leu Asn Arg Thr Val Thr Asp Asn Met Leu 
    450                 455                 460                 


Cys Ala Gly Asp Thr Arg Ser Gly Gly Pro Gln Ala Asn Leu His Asp 
465                 470                 475                 480 


Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Leu Asn Asp Gly 
                485                 490                 495     


Arg Met Thr Leu Val Gly Ile Ile Ser Trp Gly Leu Gly Cys Gly Gln 
            500                 505                 510         


Lys Asp Val Pro Gly Val Tyr Thr Lys Val Thr Asn Tyr Leu Asp Trp 
        515                 520                 525             


Ile Arg Asp Asn Met Arg Pro 
    530                 535 


<210>  30
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  his tPA

<400>  30

His His His His His His Gly Ser Ser Tyr Gln Val Ile Cys Arg Asp 
1               5                   10                  15      


Glu Lys Thr Gln Met Ile Tyr Gln Gln His Gln Ser Trp Leu Arg Pro 
            20                  25                  30          


Val Leu Arg Ser Asn Arg Val Glu Tyr Cys Trp Cys Asn Ser Gly Arg 
        35                  40                  45              


Ala Gln Cys His Ser Val Pro Val Lys Ser Cys Ser Glu Pro Arg Cys 
    50                  55                  60                  


Phe Asn Gly Gly Thr Cys Gln Gln Ala Leu Tyr Phe Ser Asp Phe Val 
65                  70                  75                  80  


Cys Gln Cys Pro Glu Gly Phe Ala Gly Lys Cys Cys Glu Ile Asp Thr 
                85                  90                  95      


Arg Ala Thr Cys Tyr Glu Asp Gln Gly Ile Ser Tyr Arg Gly Thr Trp 
            100                 105                 110         


Ser Thr Ala Glu Ser Gly Ala Glu Cys Thr Asn Trp Asn Ser Ser Ala 
        115                 120                 125             


Leu Ala Gln Lys Pro Tyr Ser Gly Arg Arg Pro Asp Ala Ile Arg Leu 
    130                 135                 140                 


Gly Leu Gly Asn His Asn Tyr Cys Arg Asn Pro Asp Arg Asp Ser Lys 
145                 150                 155                 160 


Pro Trp Cys Tyr Val Phe Lys Ala Gly Lys Tyr Ser Ser Glu Phe Cys 
                165                 170                 175     


Ser Thr Pro Ala Cys Ser Glu Gly Asn Ser Asp Cys Tyr Phe Gly Asn 
            180                 185                 190         


Gly Ser Ala Tyr Arg Gly Thr His Ser Leu Thr Glu Ser Gly Ala Ser 
        195                 200                 205             


Cys Leu Pro Trp Asn Ser Met Ile Leu Ile Gly Lys Val Tyr Thr Ala 
    210                 215                 220                 


Gln Asn Pro Ser Ala Gln Ala Leu Gly Leu Gly Lys His Asn Tyr Cys 
225                 230                 235                 240 


Arg Asn Pro Asp Gly Asp Ala Lys Pro Trp Cys His Val Leu Lys Asn 
                245                 250                 255     


Arg Arg Leu Thr Arg Glu Tyr Cys Asp Val Pro Ser Cys Ser Thr Cys 
            260                 265                 270         


Gly Leu Arg Gln Tyr Ser Gln Pro Gln Phe Ser Ile Lys Gly Gly Leu 
        275                 280                 285             


Phe Ala Asp Ile Ala Ser His Pro Trp Gln Ala Ala Ile Phe Ala Lys 
    290                 295                 300                 


His Arg Arg Ser Pro Gly Glu Arg Phe Leu Cys Gly Gly Ile Leu Ile 
305                 310                 315                 320 


Ser Ser Cys Trp Ile Leu Ser Ala Ala His Cys Phe Gln Glu Arg Phe 
                325                 330                 335     


Pro Pro His His Leu Thr Val Ile Leu Gly Arg Thr Tyr Arg Val Val 
            340                 345                 350         


Pro Gly Glu Glu Glu Gln Lys Phe Glu Val Glu Lys Tyr Ile Val His 
        355                 360                 365             


Lys Glu Phe Asp Asp Asp Thr Tyr Asp Asn Asp Ile Ala Leu Leu Gln 
    370                 375                 380                 


Leu Lys Ser Asp Ser Ser Arg Cys Ala Gln Glu Ser Ser Val Val Arg 
385                 390                 395                 400 


Thr Val Cys Leu Pro Pro Ala Asp Leu Gln Leu Pro Asp Trp Thr Glu 
                405                 410                 415     


Cys Glu Leu Ser Gly Tyr Gly Lys His Glu Ala Leu Ser Pro Phe Tyr 
            420                 425                 430         


Ser Glu Arg Leu Lys Glu Ala His Val Arg Leu Tyr Pro Ser Ser Arg 
        435                 440                 445             


Cys Thr Ser Gln His Leu Leu Asn Arg Thr Val Thr Asp Asn Met Leu 
    450                 455                 460                 


Cys Ala Gly Asp Thr Arg Ser Gly Gly Pro Gln Ala Asn Leu His Asp 
465                 470                 475                 480 


Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Leu Asn Asp Gly 
                485                 490                 495     


Arg Met Thr Leu Val Gly Ile Ile Ser Trp Gly Leu Gly Cys Gly Gln 
            500                 505                 510         


Lys Asp Val Pro Gly Val Tyr Thr Lys Val Thr Asn Tyr Leu Asp Trp 
        515                 520                 525             


Ile Arg Asp Asn Met Arg Pro 
    530                 535 


<210>  31
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  his tPA

<400>  31

His His His His His His Gly Ser Ser Tyr Gln Val Ile Cys Arg Asp 
1               5                   10                  15      


Glu Lys Thr Gln Met Ile Tyr Gln Gln His Gln Ser Trp Leu Arg Pro 
            20                  25                  30          


Val Leu Arg Ser Asn Arg Val Glu Tyr Cys Trp Cys Asn Ser Gly Arg 
        35                  40                  45              


Ala Gln Cys His Ser Val Pro Val Lys Ser Cys Ser Glu Pro Arg Cys 
    50                  55                  60                  


Phe Asn Gly Gly Thr Cys Gln Gln Ala Leu Tyr Phe Ser Asp Phe Val 
65                  70                  75                  80  


Cys Gln Cys Pro Glu Gly Phe Ala Gly Lys Cys Cys Glu Ile Asp Thr 
                85                  90                  95      


Arg Ala Thr Cys Tyr Glu Asp Gln Gly Ile Ser Tyr Arg Gly Thr Trp 
            100                 105                 110         


Ser Thr Ala Glu Ser Gly Ala Glu Cys Thr Asn Trp Asn Ser Ser Ala 
        115                 120                 125             


Leu Ala Gln Lys Arg Tyr Ser Gly Arg Arg Pro Asp Ala Ile Arg Leu 
    130                 135                 140                 


Gly Leu Gly Asn His Asn Tyr Cys Arg Asn Pro Asp Arg Asp Ser Lys 
145                 150                 155                 160 


Pro Trp Cys Tyr Val Phe Lys Ala Gly Lys Tyr Ser Ser Glu Phe Cys 
                165                 170                 175     


Ser Thr Pro Ala Cys Ser Glu Gly Asn Ser Asp Cys Tyr Phe Gly Asn 
            180                 185                 190         


Gly Ser Ala Tyr Arg Gly Thr His Ser Leu Thr Glu Ser Gly Ala Ser 
        195                 200                 205             


Cys Leu Pro Trp Asn Ser Met Ile Leu Ile Gly Lys Val Tyr Thr Ala 
    210                 215                 220                 


Gln Asn Pro Ser Ala Gln Ala Leu Gly Leu Gly Lys His Asn Tyr Cys 
225                 230                 235                 240 


Arg Asn Pro Asp Gly Asp Ala Lys Pro Trp Cys His Val Leu Lys Asn 
                245                 250                 255     


Arg Arg Leu Thr Arg Glu Tyr Cys Asp Val Pro Ser Cys Ser Thr Cys 
            260                 265                 270         


Gly Leu Arg Gln Tyr Ser Gln Pro Gln Phe Ser Ile Lys Gly Gly Leu 
        275                 280                 285             


Phe Ala Asp Ile Ala Ser His Pro Trp Gln Ala Ala Ile Phe Ala Lys 
    290                 295                 300                 


His Arg Arg Ser Pro Gly Glu Arg Phe Leu Cys Gly Gly Ile Leu Ile 
305                 310                 315                 320 


Ser Ser Cys Trp Ile Leu Ser Ala Ala His Cys Phe Gln Glu Arg Phe 
                325                 330                 335     


Pro Pro His His Leu Thr Val Ile Leu Gly Arg Thr Tyr Arg Val Val 
            340                 345                 350         


Pro Gly Glu Glu Glu Gln Lys Phe Glu Val Glu Lys Tyr Ile Val His 
        355                 360                 365             


Lys Glu Phe Asp Asp Asp Thr Tyr Asp Asn Asp Ile Ala Leu Leu Gln 
    370                 375                 380                 


Leu Lys Ser Asp Ser Ser Arg Cys Ala Gln Glu Ser Ser Val Val Arg 
385                 390                 395                 400 


Thr Val Cys Leu Pro Pro Ala Asp Leu Gln Leu Pro Asp Trp Thr Glu 
                405                 410                 415     


Cys Glu Leu Ser Gly Tyr Gly Lys His Glu Ala Leu Ser Pro Phe Tyr 
            420                 425                 430         


Ser Glu Arg Leu Lys Glu Ala His Val Arg Leu Tyr Pro Ser Ser Arg 
        435                 440                 445             


Cys Thr Ser Gln His Leu Leu Asn Arg Thr Val Thr Asp Asn Met Leu 
    450                 455                 460                 


Cys Ala Gly Asp Thr Arg Ser Gly Gly Pro Gln Ala Asn Leu His Asp 
465                 470                 475                 480 


Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Leu Asn Asp Gly 
                485                 490                 495     


Arg Met Thr Leu Val Gly Ile Ile Ser Trp Gly Leu Gly Cys Gly Gln 
            500                 505                 510         


Lys Asp Val Pro Gly Val Tyr Thr Lys Val Thr Asn Tyr Leu Asp Trp 
        515                 520                 525             


Ile Arg Asp Asn Met Arg Pro 
    530                 535 


<210>  32
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  32
ggcgctagca tggatgcaat gaagagaggg c                                      31


<210>  33
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  33
ccgggcaagc ttttgcttca tgttgtcttg aatccagtt                              39


<210>  34
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  34
gccaagcccc ggtgccacgt gc                                                22


<210>  35
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  35
gcacgtggca ccggggcttg gc                                                22


<210>  36
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  36
gtacagccag cctcagttta gcatcaaagg agggc                                  35


<210>  37
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  37
aaactgaggc tggctgtact gtctcaggcc gc                                     32


<210>  38
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  38
gcagcgcgtt ggcccagaag cgctacagcg ggc                                    33


<210>  39
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  39
cttctgggcc aacgcgctgc tgttccagtt gg                                     32


