                         SEQUENCE LISTING

<110>  Synageva BioPharma Corp., et al.
       
 
<120>  TRANSGENIC BIRDS THAT PRODUCE CHIMERIC HUMAN IMMUNOGLOBULINS

<130>  121424-00820

<150>  61/530,323
<151>  2011-09-01

<150>  61/582,260
<151>  2011-12-31

<160>  62    

<170>  PatentIn version 3.5

<210>  1
<211>  23
<212>  DNA
<213>  Synthetic oligonucleotide

<400>  1
agaccctcgg acatcccttc acg                                               23


<210>  2
<211>  24
<212>  DNA
<213>  Synthetic oligonucleotide

<400>  2
aaaaccccca aatcaccaaa aatc                                              24


<210>  3
<211>  22
<212>  DNA
<213>  Synthetic oligonucleotide

<400>  3
acgacagact tgaggggttc tc                                                22


<210>  4
<211>  20
<212>  DNA
<213>  Synthetic oligonucleotide

<400>  4
gctcttcagc aatatcacgg                                                   20


<210>  5
<211>  25
<212>  DNA
<213>  Synthetic oligonucleotide

<400>  5
aggatcctgt agagcctcag gactg                                             25


<210>  6
<211>  21
<212>  DNA
<213>  Synthetic oligonucleotide

<400>  6
gaactctcta tgaccatggc c                                                 21


<210>  7
<211>  23
<212>  DNA
<213>  Synthetic oligonucleotide

<400>  7
agaccctcgg acatcccttc acg                                               23


<210>  8
<211>  24
<212>  DNA
<213>  Synthetic oligonucleotide

<400>  8
aaaaccccca aatcaccaaa aatc                                              24


<210>  9
<211>  22
<212>  DNA
<213>  Synthetic oligonucleotide

<400>  9
acgacagact tgaggggttc tc                                                22


<210>  10
<211>  20
<212>  DNA
<213>  Synthetic oligonucleotide

<400>  10
gctcttcagc aatatcacgg                                                   20


<210>  11
<211>  24
<212>  DNA
<213>  Synthetic oligonucleotide

<400>  11
gcttctcttc ctcctgctac tctg                                              24


<210>  12
<211>  24
<212>  DNA
<213>  Synthetic oligonucleotide

<400>  12
aaaaccccca aatcaccaaa aatc                                              24


<210>  13
<211>  24
<212>  DNA
<213>  Synthetic oligonucleotide

<400>  13
gcttctcttc ctcctgctac tctg                                              24


<210>  14
<211>  23
<212>  DNA
<213>  Synthetic oligonucleotide

<400>  14
ttcgttcagc tcctcctttg acg                                               23


<210>  15
<211>  22
<212>  DNA
<213>  Synthetic oligonucleotide

<400>  15
gtttgatttc caccttggtc cc                                                22


<210>  16
<211>  23
<212>  DNA
<213>  Synthetic oligonucleotide

<400>  16
agaaagaccg agacgaggtc agc                                               23


<210>  17
<211>  21
<212>  DNA
<213>  Synthetic oligonucleotide

<400>  17
aacaccccag ccatgtatgt a                                                 21


<210>  18
<211>  20
<212>  DNA
<213>  Synthetic oligonucleotide

<400>  18
tttcattgtg ctaggtgcca                                                   20


<210>  19
<211>  24
<212>  DNA
<213>  Synthetic oligonucleotide

<400>  19
gcttctcttc ctcctgctac tctg                                              24


<210>  20
<211>  23
<212>  DNA
<213>  Synthetic oligonucleotide

<400>  20
ttcgttcagc tcctcctttg acg                                               23


<210>  21
<211>  21
<212>  DNA
<213>  Synthetic oligonucleotide

<400>  21
aacaccccag ccatgtatgt a                                                 21


<210>  22
<211>  20
<212>  DNA
<213>  Synthetic oligonucleotide

<400>  22
tttcattgtg ctaggtgcca                                                   20


<210>  23
<211>  24
<212>  DNA
<213>  Synthetic oligonucleotide

<400>  23
gcttctcttc ctcctgctac tctg                                              24


<210>  24
<211>  23
<212>  DNA
<213>  Synthetic oligonucleotide

<400>  24
ttcgttcagc tcctcctttg acg                                               23


<210>  25
<211>  22
<212>  DNA
<213>  Synthetic oligonucleotide

<400>  25
gtttgatttc caccttggtc cc                                                22


<210>  26
<211>  374
<212>  DNA
<213>  Human

<400>  26
agatctctgt gcccgcagtc acatgtggaa tatcaagaca cacacatcta tgacaatctc       60

caggcaccct gtctttgtct ccaggggaaa gagccaccct ctcctgcagg gccactgaga      120

gtgttagcaa cacctactta gcctggtacc agcagaaacc tggccaggct cctaggctcc      180

tcatctatgg tgtatcgagc agggccactg gcatcccaga caggttcagt ggcagtgggt      240

ctgggacaga cttcactctc accatcagca gactggagcc tgaagatttt gcagtgtatt      300

actgtcagca gtatggtagc tcacctccga aggtcacctt cggccaaggg accaaggtgg      360

aaatcaaagg atcc                                                        374


<210>  27
<211>  371
<212>  DNA
<213>  Human

<400>  27
ggatcctctc caggcaccct gtctttgtct ccaggggaaa gagccaccct ctcctgcagg       60

gccagtcaga ctattagcag cacctactta gcctggtacc agcagaaacc tggccaggct      120

cctaggctcc tcatctatgg ttcatccagc agggccactg gcatcccaga caggttcagt      180

ggcagtgggt ctgggacaga cttcactctc accatcagca gactggagcc tgaagatttt      240

gcagtgtatt actgtcagca gtttggtagc tcacctttat tcactttcgg ccaagggacc      300

aaggtggaaa tcaaaaccat ggatagagct gggagccctc actgccactc atgccttcag      360

gtgtcagatc t                                                           371


<210>  28
<211>  371
<212>  DNA
<213>  Human

<400>  28
agatcttgta gtgagcaggg agagcactgc aataggagct gatagtgatc acacagtctc       60

caggcaccct gtctttgtct ccaggggaaa gagccaccct ctcctgcagg gccagtcaga      120

gttttagcag caactactta gcctggtacc agcagaaacc tggccaggct cctaggctcc      180

tcatctatga tgcatccagc agggccactg gcatcccaga caggttcagt ggcagtgggt      240

ctgggacaga cttcactctc accatcagca gactggagcc tgaagatttt gcagtgtatt      300

actgtcagca gtatggtagc tcaccttcgt acacttttgg ccaagggacc aaggtggaaa      360

tcaaaggatc c                                                           371


<210>  29
<211>  368
<212>  DNA
<213>  Human

<400>  29
ggatcctctc caggcaccct gtctttgtct ccaggggaaa gagccaccct ctcctgcagg       60

gccagtcaga gtatgagcag cagctactta gcctggtacc agcagaaacc tggccaggct      120

cctaggctcc tcatctatgg agcatccagc agggccactg gcatcccaga caggttcagt      180

ggcagtgggt ctgggacaga cttcactctc accatcagca gactggagcc tgaagatttt      240

gcagtgtatt actgtcagct gtttgatagc tcaccattca ctttcggcca agggaccaag      300

gtggaaatca aaagtcggtg tttgaatatt ctgtgtgtgc ttgtgtgctc tggggtctcc      360

tcagatct                                                               368


<210>  30
<211>  365
<212>  DNA
<213>  Human

<400>  30
agatctaggc agacagaaac ctgtcatttt tagctctaga catcacatca ctcccatctc       60

caggcaccct gtctttgtct ccaggggaaa gagccaccct ctcctgcagg gccagtcaga      120

gtgtcagcga cagctactta gcctggtacc agcagaaacc tggccaggct cctaggctcc      180

tcatctatgg tgcatcaagc agggccactg gcatcccaga caggttcagt ggcagtgggt      240

ctgggacaga cttcactctc accatcagca gactggagcc tgaagatttt gcagtgtatt      300

actgtcagca gtatggtggc tcagacattt tcggccaagg gaccaaggtg gaaatcaaag      360

gatcc                                                                  365


<210>  31
<211>  365
<212>  DNA
<213>  Human

<400>  31
ggatcctctc caggcaccct gtctttgtct ccaggggaaa gagccaccct ctcctgcagg       60

gccagtcaga gtcttagcag cagcaactta gcctggtacc agcagaaacc tggccaggct      120

cctaggctcc tcatctatag tgcatccagc agggccactg gcatcccaga caggttcagt      180

ggcagtgggt ctgggacaga cttcactctc accatcagca gactggagcc tgaagatttt      240

gcagtgtatt actgtcagca gtatcatacc tcacggacgt tcggccaagg gaccaaggtg      300

gaaatcaaat gctggtatag agacaaaaga ggatgtggaa ctgagttaca gacctgagta      360

gatct                                                                  365


<210>  32
<211>  368
<212>  DNA
<213>  Human

<400>  32
agatcttatc tccctgtgtc tctgtaccta caaaactgct gtcataggcc ccactatctc       60

caggcaccct gtctttgtct ccaggggaaa gagccaccct ctcctgcagg gccagtcaga      120

gtcttaccag cagctactta gcctggtacc agcagaaacc tggccaggct cctaggctcc      180

tcatctctgg tgcatccagc agggccactg gcatcccaga caggttcagt ggcagtgggt      240

ctgggacaga cttcactctc accatcagca gactggagcc tgaagatttt gcagtgtatt      300

actgtcagca gtatggtagt ttacccctca ctttcggcca agggaccaag gtggaaatca      360

aaggatcc                                                               368


<210>  33
<211>  374
<212>  DNA
<213>  Human

<400>  33
ggatcctctc caggcaccct gtctttgtct ccaggggaaa gagccaccct ctcctgcagg       60

gccagtcaga gtcttactag cagctactta gcctggtacc agcagaaacc tggccaggct      120

cctaggctcc tcatctatag tgcatccagc agggccactg gcatcccaga caggttcagt      180

ggcagtgggt ctgggacaga cttcactctc accatcagca gactggagcc tgaagatttt      240

gcagtgtatt actgtcagca gtatggtagc tcacctccca tgtacacttt tggccaaggg      300

accaaggtgg aaatcaaatc tggggtaaca gtcaaggtct tggccattca gataggacaa      360

ggcctcctag atct                                                        374


<210>  34
<211>  365
<212>  DNA
<213>  Human

<400>  34
agatctactg tcacactaac taccactgtg gtctaagctg tggagaacac tgcccatctc       60

caggcaccct gtctttgtct ccaggggaaa gagccaccct ctcctgcagg gccagtcaga      120

gtgttagcag cacctactta gcctggtacc agcagaaacc tggccaggct cctaggctcc      180

tcatctatga tgcatccagc agggccactg gcatcccaga caggttcagt ggcagtgggt      240

ctgggacaga cttcactctc accatcagca gactggagcc tgaagatttt gcagtgtatt      300

actgtcagca gtctggtaac ttaatcactt tcggccaagg gaccaaggtg gaaatcaaag      360

gatcc                                                                  365


<210>  35
<211>  363
<212>  DNA
<213>  Human

<400>  35
ggatccccag gcaccctgtc tttgtctcca ggggaaagag ccaccctctc ctgcagggcc       60

agtcagagtg ttagcggcag ctacttagcc tggtaccagc agaaacctgg ccaggctcct      120

aggctcctca tctatgatgc atccagcagg gccactggca tcccagacag gttcagtggc      180

agtgggtctg ggacagactt cactctcacc atcagcagac tggagcctga agattttgca      240

gtgtattact gtcaggtgta tgttagttca cctccggcgt gggcgttcgg ccaagggacc      300

aaggtggaaa tcaaaagatc tataacttcg tataatgtat gctatacgaa gttatgcggc      360

cgc                                                                    363


<210>  36
<211>  384
<212>  DNA
<213>  Human

<400>  36
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgta gggccagtca gagtgttcgc ggcaggtact tagcctggta ccagcagaaa      180

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      240

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      300

cctgaagatt ttgcagtgtt ttactgtcag cagtatggta gttcacctcg gacgttcggc      360

caagggacca aggtggaaat caaa                                             384


<210>  37
<211>  108
<212>  PRT
<213>  Human

<400>  37

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Gly Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Phe Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  38
<211>  108
<212>  PRT
<213>  Human

<400>  38

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  39
<211>  348
<212>  DNA
<213>  Human

<400>  39
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgta gggccagtca gagtgttcgc ggcaggtact tagcctggta ccagcagaaa      180

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      240

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      300

cctgaagatt ttgcagtgtt ttactgtcag cagtatggta gttcacct                   348


<210>  40
<211>  473
<212>  DNA
<213>  Human

<400>  40
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccagg tactcgttgc       60

gcccggtcgg ggactgtggg cacggggctc tgtcccactg ctgcgcgggc agggctgtgc      120

gtgcggggcc gtcactgatt gccgttttct cccctctctc ctctccctct ccagatacca      180

ccggagaaat tgtgttgacg cagtctccag gcaccctgtc tttgtctcca ggggaaagag      240

ccaccctctc ctgtagggcc agtcagagtg ttcgcggcag gtacttagcc tggtaccagc      300

agaaacctgg ccaggctccc aggctcctca tctatggtgc atccagcagg gccactggca      360

tcccagacag gttcagtggc agtgggtctg ggacagactt cactctcacc atcagcagac      420

tggagcctga agattttgca gtgttttact gtcagcagta tggtagttca cct             473


<210>  41
<211>  102
<212>  PRT
<213>  Human

<400>  41

Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
1               5                   10                  15      


Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln 
            20                  25                  30          


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser 
        35                  40                  45              


Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Trp Thr Phe Gly Gln Gly 
                85                  90                  95      


Thr Lys Val Glu Ile Lys 
            100         


<210>  42
<211>  104
<212>  PRT
<213>  HUMAN

<400>  42

Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
1               5                   10                  15      


Cys Arg Ala Thr Glu Ser Val Ser Asn Thr Tyr Leu Ala Trp Tyr Gln 
            20                  25                  30          


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Val Ser Ser 
        35                  40                  45              


Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Pro Lys Val Thr Phe Gly 
                85                  90                  95      


Gln Gly Thr Lys Val Glu Ile Lys 
            100                 


<210>  43
<211>  103
<212>  PRT
<213>  HUMAN

<400>  43

Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
1               5                   10                  15      


Cys Arg Ala Ser Gln Thr Ile Ser Ser Thr Tyr Leu Ala Trp Tyr Gln 
            20                  25                  30          


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ser Ser Ser 
        35                  40                  45              


Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Phe Gly Ser Ser Pro Leu Phe Thr Phe Gly Gln 
                85                  90                  95      


Gly Thr Lys Val Glu Ile Lys 
            100             


<210>  44
<211>  103
<212>  PRT
<213>  HUMAN

<400>  44

Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
1               5                   10                  15      


Cys Arg Ala Ser Gln Ser Phe Ser Ser Asn Tyr Leu Ala Trp Tyr Gln 
            20                  25                  30          


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Ser 
        35                  40                  45              


Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Ser Tyr Thr Phe Gly Gln 
                85                  90                  95      


Gly Thr Lys Val Glu Ile Lys 
            100             


<210>  45
<211>  102
<212>  PRT
<213>  HUMAN

<400>  45

Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
1               5                   10                  15      


Cys Arg Ala Ser Gln Ser Met Ser Ser Ser Tyr Leu Ala Trp Tyr Gln 
            20                  25                  30          


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser 
        35                  40                  45              


Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gln Leu Phe Asp Ser Ser Pro Phe Thr Phe Gly Gln Gly 
                85                  90                  95      


Thr Lys Val Glu Ile Lys 
            100         


<210>  46
<211>  101
<212>  PRT
<213>  HUMAN

<400>  46

Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
1               5                   10                  15      


Cys Arg Ala Ser Gln Ser Val Ser Asp Ser Tyr Leu Ala Trp Tyr Gln 
            20                  25                  30          


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser 
        35                  40                  45              


Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Asp Ile Phe Gly Gln Gly Thr 
                85                  90                  95      


Lys Val Glu Ile Lys 
            100     


<210>  47
<211>  101
<212>  PRT
<213>  HUMAN

<400>  47

Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
1               5                   10                  15      


Cys Arg Ala Ser Gln Ser Leu Ser Ser Ser Asn Leu Ala Trp Tyr Gln 
            20                  25                  30          


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Ser Ala Ser Ser 
        35                  40                  45              


Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Tyr His Thr Ser Arg Thr Phe Gly Gln Gly Thr 
                85                  90                  95      


Lys Val Glu Ile Lys 
            100     


<210>  48
<211>  102
<212>  PRT
<213>  Human

<400>  48

Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
1               5                   10                  15      


Cys Arg Ala Ser Gln Ser Leu Thr Ser Ser Tyr Leu Ala Trp Tyr Gln 
            20                  25                  30          


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Ser Gly Ala Ser Ser 
        35                  40                  45              


Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Tyr Gly Ser Leu Pro Leu Thr Phe Gly Gln Gly 
                85                  90                  95      


Thr Lys Val Glu Ile Lys 
            100         


<210>  49
<211>  104
<212>  PRT
<213>  HUMAN

<400>  49

Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
1               5                   10                  15      


Cys Arg Ala Ser Gln Ser Leu Thr Ser Ser Tyr Leu Ala Trp Tyr Gln 
            20                  25                  30          


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Ser Ala Ser Ser 
        35                  40                  45              


Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Pro Met Tyr Thr Phe Gly 
                85                  90                  95      


Gln Gly Thr Lys Val Glu Ile Lys 
            100                 


<210>  50
<211>  101
<212>  PRT
<213>  HUMAN

<400>  50

Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
1               5                   10                  15      


Cys Arg Ala Ser Gln Ser Val Ser Ser Thr Tyr Leu Ala Trp Tyr Gln 
            20                  25                  30          


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Ser 
        35                  40                  45              


Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Ser Gly Asn Leu Ile Thr Phe Gly Gln Gly Thr 
                85                  90                  95      


Lys Val Glu Ile Lys 
            100     


<210>  51
<211>  104
<212>  PRT
<213>  HUMAN

<400>  51

Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
1               5                   10                  15      


Cys Arg Ala Ser Gln Ser Val Ser Gly Ser Tyr Leu Ala Trp Tyr Gln 
            20                  25                  30          


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Ser 
        35                  40                  45              


Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gln Val Tyr Val Ser Ser Pro Pro Ala Trp Ala Phe Gly 
                85                  90                  95      


Gln Gly Thr Lys Val Glu Ile Lys 
            100                 


<210>  52
<211>  294
<212>  DNA
<213>  HUMAN

<400>  52
tctccaggca ccctgtcttt gtctccaggg gaaagagcca ccctctcctg tagggccagt       60

cagagtgttc gcggcaggta cttagcctgg taccagcaga aacctggcca ggctcccagg      120

ctcctcatct atggtgcatc cagcagggcc actggcatcc cagacaggtt cagtggcagt      180

gggtctggga cagacttcac tctcaccatc agcagactgg agcctgaaga ttttgcagtg      240

ttttactgtc agcagtatgg tagttcacct cggacgttcg gccaagggac caag            294


<210>  53
<211>  300
<212>  DNA
<213>  HUMAN

<400>  53
tctccaggca ccctgtcttt gtctccaggg gaaagagcca ccctctcctg cagggccact       60

gagagtgtta gcaacaccta cttagcctgg taccagcaga aacctggcca ggctcctagg      120

ctcctcatct atggtgtatc gagcagggcc actggcatcc cagacaggtt cagtggcagt      180

gggtctggga cagacttcac tctcaccatc agcagactgg agcctgaaga ttttgcagtg      240

tattactgtc agcagtatgg tagctcacct ccgaaggtca ccttcggcca agggaccaag      300


<210>  54
<211>  297
<212>  DNA
<213>  HUMAN

<400>  54
tctccaggca ccctgtcttt gtctccaggg gaaagagcca ccctctcctg cagggccagt       60

cagactatta gcagcaccta cttagcctgg taccagcaga aacctggcca ggctcctagg      120

ctcctcatct atggttcatc cagcagggcc actggcatcc cagacaggtt cagtggcagt      180

gggtctggga cagacttcac tctcaccatc agcagactgg agcctgaaga ttttgcagtg      240

tattactgtc agcagtttgg tagctcacct ttattcactt tcggccaagg gaccaag         297


<210>  55
<211>  297
<212>  DNA
<213>  HUMAN

<400>  55
tctccaggca ccctgtcttt gtctccaggg gaaagagcca ccctctcctg cagggccagt       60

cagagtttta gcagcaacta cttagcctgg taccagcaga aacctggcca ggctcctagg      120

ctcctcatct atgatgcatc cagcagggcc actggcatcc cagacaggtt cagtggcagt      180

gggtctggga cagacttcac tctcaccatc agcagactgg agcctgaaga ttttgcagtg      240

tattactgtc agcagtatgg tagctcacct tcgtacactt ttggccaagg gaccaag         297


<210>  56
<211>  294
<212>  DNA
<213>  HUMAN

<400>  56
tctccaggca ccctgtcttt gtctccaggg gaaagagcca ccctctcctg cagggccagt       60

cagagtatga gcagcagcta cttagcctgg taccagcaga aacctggcca ggctcctagg      120

ctcctcatct atggagcatc cagcagggcc actggcatcc cagacaggtt cagtggcagt      180

gggtctggga cagacttcac tctcaccatc agcagactgg agcctgaaga ttttgcagtg      240

tattactgtc agctgtttga tagctcacca ttcactttcg gccaagggac caag            294


<210>  57
<211>  291
<212>  DNA
<213>  HUMAN

<400>  57
tctccaggca ccctgtcttt gtctccaggg gaaagagcca ccctctcctg cagggccagt       60

cagagtgtca gcgacagcta cttagcctgg taccagcaga aacctggcca ggctcctagg      120

ctcctcatct atggtgcatc aagcagggcc actggcatcc cagacaggtt cagtggcagt      180

gggtctggga cagacttcac tctcaccatc agcagactgg agcctgaaga ttttgcagtg      240

tattactgtc agcagtatgg tggctcagac attttcggcc aagggaccaa g               291


<210>  58
<211>  291
<212>  DNA
<213>  HUMAN

<400>  58
tctccaggca ccctgtcttt gtctccaggg gaaagagcca ccctctcctg cagggccagt       60

cagagtctta gcagcagcaa cttagcctgg taccagcaga aacctggcca ggctcctagg      120

ctcctcatct atagtgcatc cagcagggcc actggcatcc cagacaggtt cagtggcagt      180

gggtctggga cagacttcac tctcaccatc agcagactgg agcctgaaga ttttgcagtg      240

tattactgtc agcagtatca tacctcacgg acgttcggcc aagggaccaa g               291


<210>  59
<211>  294
<212>  DNA
<213>  HUMAN

<400>  59
tctccaggca ccctgtcttt gtctccaggg gaaagagcca ccctctcctg cagggccagt       60

cagagtctta ccagcagcta cttagcctgg taccagcaga aacctggcca ggctcctagg      120

ctcctcatct ctggtgcatc cagcagggcc actggcatcc cagacaggtt cagtggcagt      180

gggtctggga cagacttcac tctcaccatc agcagactgg agcctgaaga ttttgcagtg      240

tattactgtc agcagtatgg tagtttaccc ctcactttcg gccaagggac caag            294


<210>  60
<211>  300
<212>  DNA
<213>  HUMAN

<400>  60
tctccaggca ccctgtcttt gtctccaggg gaaagagcca ccctctcctg cagggccagt       60

cagagtctta ctagcagcta cttagcctgg taccagcaga aacctggcca ggctcctagg      120

ctcctcatct atagtgcatc cagcagggcc actggcatcc cagacaggtt cagtggcagt      180

gggtctggga cagacttcac tctcaccatc agcagactgg agcctgaaga ttttgcagtg      240

tattactgtc agcagtatgg tagctcacct cccatgtaca cttttggcca agggaccaag      300


<210>  61
<211>  291
<212>  DNA
<213>  HUMAN

<400>  61
tctccaggca ccctgtcttt gtctccaggg gaaagagcca ccctctcctg cagggccagt       60

cagagtgtta gcagcaccta cttagcctgg taccagcaga aacctggcca ggctcctagg      120

ctcctcatct atgatgcatc cagcagggcc actggcatcc cagacaggtt cagtggcagt      180

gggtctggga cagacttcac tctcaccatc agcagactgg agcctgaaga ttttgcagtg      240

tattactgtc agcagtctgg taacttaatc actttcggcc aagggaccaa g               291


<210>  62
<211>  300
<212>  DNA
<213>  HUMAN

<400>  62
tctccaggca ccctgtcttt gtctccaggg gaaagagcca ccctctcctg cagggccagt       60

cagagtgtta gcggcagcta cttagcctgg taccagcaga aacctggcca ggctcctagg      120

ctcctcatct atgatgcatc cagcagggcc actggcatcc cagacaggtt cagtggcagt      180

gggtctggga cagacttcac tctcaccatc agcagactgg agcctgaaga ttttgcagtg      240

tattactgtc aggtgtatgt tagttcacct ccggcgtggg cgttcggcca agggaccaag      300


