                         SEQUENCE LISTING

<110>  Srivastava, Deepak
       Fu, Jidong
 
<120>  Methods for Generating Cardiomyocytes

<130>  GLAD-400WO

<150>  61/529,042
<151>  2011-08-30

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Asn Lys Asp Arg His Ile Asp Ser Ser Cys Ser Ser Phe Ile 
1               5                   10                  15      


Lys Thr Glu Pro Ser Ser Pro Ala Ser Leu Thr Asp Ser Val Asn His 
            20                  25                  30          


His Ser Pro Gly Gly Ser Ser Asp Ala Ser Gly Ser Tyr Ser Ser Thr 
        35                  40                  45              


Met Asn Gly His Gln Asn Gly Leu Asp Ser Pro Pro Leu Tyr Pro Ser 
    50                  55                  60                  


Ala Pro Ile Leu Gly Gly Ser Gly Pro Val Arg Lys Leu Tyr Asp Asp 
65                  70                  75                  80  


Cys Ser Ser Thr Ile Val Glu Asp Pro Gln Thr Lys Cys Glu Tyr Met 
                85                  90                  95      


Leu Asn Ser Met Pro Lys Arg Leu Cys Leu Val Cys Gly Asp Ile Ala 
            100                 105                 110         


Ser Gly Tyr His Tyr Gly Val Ala Ser Cys Glu Ala Cys Lys Ala Phe 
        115                 120                 125             


Phe Lys Arg Thr Ile Gln Gly Asn Ile Glu Tyr Ser Cys Pro Ala Thr 
    130                 135                 140                 


Asn Glu Cys Glu Ile Thr Lys Arg Arg Arg Lys Ser Cys Gln Ala Cys 
145                 150                 155                 160 


Arg Phe Met Lys Cys Leu Lys Val Gly Met Leu Lys Glu Gly Val Arg 
                165                 170                 175     


Leu Asp Arg Val Arg Gly Gly Arg Gln Lys Tyr Lys Arg Arg Ile Asp 
            180                 185                 190         


Ala Glu Asn Ser Pro Tyr Leu Asn Pro Gln Leu Val Gln Pro Ala Lys 
        195                 200                 205             


Lys Pro Tyr Asn Lys Ile Val Ser His Leu Leu Val Ala Glu Pro Glu 
    210                 215                 220                 


Lys Ile Tyr Ala Met Pro Asp Pro Thr Val Pro Asp Ser Asp Ile Lys 
225                 230                 235                 240 


Ala Leu Thr Thr Leu Cys Asp Leu Ala Asp Arg Glu Leu Val Val Ile 
                245                 250                 255     


Ile Gly Trp Ala Lys His Ile Pro Gly Phe Ser Thr Leu Ser Leu Ala 
            260                 265                 270         


Asp Gln Met Ser Leu Leu Gln Ser Ala Trp Met Glu Ile Leu Ile Leu 
        275                 280                 285             


Gly Val Val Tyr Arg Ser Leu Ser Phe Glu Asp Glu Leu Val Tyr Ala 
    290                 295                 300                 


Asp Asp Tyr Ile Met Asp Glu Asp Gln Ser Lys Leu Ala Gly Leu Leu 
305                 310                 315                 320 


Asp Leu Asn Asn Ala Ile Leu Gln Leu Val Lys Lys Tyr Lys Ser Met 
                325                 330                 335     


Lys Leu Glu Lys Glu Glu Phe Val Thr Leu Lys Ala Ile Ala Leu Ala 
            340                 345                 350         


Asn Ser Asp Ser Met His Ile Glu Asp Val Glu Ala Val Gln Lys Leu 
        355                 360                 365             


Gln Asp Val Leu His Glu Ala Leu Gln Asp Tyr Glu Ala Gly Gln His 
    370                 375                 380                 


Met Glu Asp Pro Arg Arg Ala Gly Lys Met Leu Met Thr Leu Pro Leu 
385                 390                 395                 400 


Leu Arg Gln Thr Ser Thr Lys Ala Val Gln His Phe Tyr Asn Ile Lys 
                405                 410                 415     


Leu Glu Gly Lys Val Pro Met His Lys Leu Phe Leu Glu Met Leu Glu 
            420                 425                 430         


Ala Lys Val 
        435 


<210>  2
<211>  1308
<212>  DNA
<213>  Homo sapiens

<400>  2
atgtcaaaca aagatcgaca cattgattcc agctgttcgt ccttcatcaa gacggaacct       60

tccagcccag cctccctgac ggacagcgtc aaccaccaca gccctggtgg ctcttcagac      120

gccagtggga gctacagttc aaccatgaat ggccatcaga acggacttga ctcgccacct      180

ctctaccctt ctgctcctat cctgggaggt agtgggcctg tcaggaaact gtatgatgac      240

tgctccagca ccattgttga agatccccag accaagtgtg aatacatgct caactcgatg      300

cccaagagac tgtgtttagt gtgtggtgac atcgcttctg ggtaccacta tggggtagca      360

tcatgtgaag cctgcaaggc attcttcaag aggacaattc aaggcaatat agaatacagc      420

tgccctgcca cgaatgaatg tgaaatcaca aagcgcagac gtaaatcctg ccaggcttgc      480

cgcttcatga agtgtttaaa agtgggcatg ctgaaagaag gggtgcgtct tgacagagta      540

cgtggaggtc ggcagaagta caagcgcagg atagatgcgg agaacagccc atacctgaac      600

cctcagctgg ttcagccagc caaaaagcca tataacaaga ttgtctcaca tttgttggtg      660

gctgaaccgg agaagatcta tgccatgcct gaccctactg tccccgacag tgacatcaaa      720

gccctcacta cactgtgtga cttggccgac cgagagttgg tggttatcat tggatgggcg      780

aagcatattc caggcttctc cacgctgtcc ctggcggacc agatgagcct tctgcagagt      840

gcttggatgg aaattttgat ccttggtgtc gtataccggt ctctttcgtt tgaggatgaa      900

cttgtctatg cagacgatta tataatggac gaagaccagt ccaaattagc aggccttctt      960

gatctaaata atgctatcct gcagctggta aagaaataca agagcatgaa gctggaaaaa     1020

gaagaatttg tcaccctcaa agctatagct cttgctaatt cagactccat gcacatagaa     1080

gatgttgaag ccgttcagaa gcttcaggat gtcttacatg aagcgctgca ggattatgaa     1140

gctggccagc acatggaaga ccctcgtcga gctggcaaga tgctgatgac actgccactc     1200

ctgaggcaga cctctaccaa ggccgtgcag catttctaca acatcaaact agaaggcaaa     1260

gtcccaatgc acaaactttt tttggaaatg ttggaggcca aggtctga                  1308


<210>  3
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Asn Lys Asp Arg His Ile Asp Ser Ser Cys Ser Ser Phe Ile 
1               5                   10                  15      


Lys Thr Glu Pro Ser Ser Pro Ala Ser Leu Thr Asp Ser Val Asn His 
            20                  25                  30          


His Ser Pro Gly Gly Ser Ser Asp Ala Ser Gly Ser Tyr Ser Ser Thr 
        35                  40                  45              


Met Asn Gly His Gln Asn Gly Leu Asp Ser Pro Pro Leu Tyr Pro Ser 
    50                  55                  60                  


Ala Pro Ile Leu Gly Gly Ser Gly Pro Val Arg Lys Leu Tyr Asp Asp 
65                  70                  75                  80  


Cys Ser Ser Thr Ile Val Glu Asp Pro Gln Thr Lys Cys Glu Tyr Met 
                85                  90                  95      


Leu Asn Ser Met Pro Lys Arg Leu Cys Leu Val Cys Gly Asp Ile Ala 
            100                 105                 110         


Ser Gly Tyr His Tyr Gly Val Ala Ser Cys Glu Ala Cys Lys Ala Phe 
        115                 120                 125             


Phe Lys Arg Thr Ile Gln Gly Asn Ile Glu Tyr Ser Cys Pro Ala Thr 
    130                 135                 140                 


Asn Glu Cys Glu Ile Thr Lys Arg Arg Arg Lys Ser Cys Gln Ala Cys 
145                 150                 155                 160 


Arg Phe Met Lys Cys Leu Lys Val Gly Met Leu Lys Glu Gly Val Arg 
                165                 170                 175     


Leu Asp Arg Val Arg Gly Gly Arg Gln Lys Tyr Lys Arg Arg Ile Asp 
            180                 185                 190         


Ala Glu Asn Ser Pro Tyr Leu Asn Pro Gln Leu Val Gln Pro Ala Lys 
        195                 200                 205             


Lys Pro Tyr Asn Lys Ile Val Ser His Leu Leu Val Ala Glu Pro Glu 
    210                 215                 220                 


Lys Ile Tyr Ala Met Pro Asp Pro Thr Val Pro Asp Ser Asp Ile Lys 
225                 230                 235                 240 


Ala Leu Thr Thr Leu Cys Asp Leu Ala Asp Arg Glu Leu Val Val Ile 
                245                 250                 255     


Ile Gly Trp Ala Lys His Ile Pro Gly Phe Ser Thr Leu Ser Leu Ala 
            260                 265                 270         


Asp Gln Met Ser Leu Leu Gln Ser Ala Trp Met Glu Ile Leu Ile Leu 
        275                 280                 285             


Gly Val Val Tyr Arg Ser Leu Ser Phe Glu Asp Glu Leu Val Tyr Ala 
    290                 295                 300                 


Asp Asp Tyr Ile Met Asp Glu Asp Gln Ser Lys Leu Ala Gly Leu Leu 
305                 310                 315                 320 


Asp Leu Asn Asn Ala Ile Leu Gln Leu Val Lys Lys Tyr Lys Ser Met 
                325                 330                 335     


Lys Leu Glu Lys Glu Glu Phe Val Thr Leu Lys Ala Ile Ala Leu Ala 
            340                 345                 350         


Asn Ser Asp Ser Met His Ile Glu Asp Val Glu Ala Val Gln Lys Leu 
        355                 360                 365             


Gln Asp Val Leu His Glu Ala Leu Gln Asp Tyr Glu Ala Gly Gln His 
    370                 375                 380                 


Met Glu Asp Pro Arg Arg Ala Gly Lys Met Leu Met Thr Leu Pro Leu 
385                 390                 395                 400 


Leu Arg Gln Thr Ser Thr Lys Ala Val Gln His Phe Tyr Asn Ile Lys 
                405                 410                 415     


Leu Glu Gly Lys Val Pro Met His Lys Leu Phe Leu Glu Met Leu Glu 
            420                 425                 430         


Ala Lys Val 
        435 


<210>  4
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Asn Lys Asp Arg His Ile Asp Ser Ser Cys Ser Ser Phe Ile 
1               5                   10                  15      


Lys Thr Glu Pro Ser Ser Pro Ala Ser Leu Thr Asp Ser Val Asn His 
            20                  25                  30          


His Ser Pro Gly Gly Ser Ser Asp Ala Ser Gly Ser Tyr Ser Ser Thr 
        35                  40                  45              


Met Asn Gly His Gln Asn Gly Leu Asp Ser Pro Pro Leu Tyr Pro Ser 
    50                  55                  60                  


Ala Pro Ile Leu Gly Gly Ser Gly Pro Val Arg Lys Leu Tyr Asp Asp 
65                  70                  75                  80  


Cys Ser Ser Thr Ile Val Glu Asp Pro Gln Thr Lys Cys Glu Tyr Met 
                85                  90                  95      


Leu Asn Ser Met Pro Lys Arg Leu Cys Leu Val Cys Gly Asp Ile Ala 
            100                 105                 110         


Ser Gly Tyr His Tyr Gly Val Ala Ser Cys Glu Ala Cys Lys Ala Phe 
        115                 120                 125             


Phe Lys Arg Thr Ile Gln Gly Asn Ile Glu Tyr Ser Cys Pro Ala Thr 
    130                 135                 140                 


Asn Glu Cys Glu Ile Thr Lys Arg Arg Arg Lys Ser Cys Gln Ala Cys 
145                 150                 155                 160 


Arg Phe Met Lys Cys Leu Lys Val Gly Met Leu Lys Glu Gly Val Arg 
                165                 170                 175     


Leu Asp Arg Val Arg Gly Gly Arg Gln Lys Tyr Lys Arg Arg Ile Asp 
            180                 185                 190         


Ala Glu Asn Ser Pro Tyr Leu Asn Pro Gln Leu Val Gln Pro Ala Lys 
        195                 200                 205             


Lys Pro Leu Leu Trp Ser Asp Pro Ala Asp Asn Lys Ile Val Ser His 
    210                 215                 220                 


Leu Leu Val Ala Glu Pro Glu Lys Ile Tyr Ala Met Pro Asp Pro Thr 
225                 230                 235                 240 


Val Pro Asp Ser Asp Ile Lys Ala Leu Thr Thr Leu Cys Asp Leu Ala 
                245                 250                 255     


Asp Arg Glu Leu Val Val Ile Ile Gly Trp Ala Lys His Ile Pro Gly 
            260                 265                 270         


Phe Ser Thr Leu Ser Leu Ala Asp Gln Met Ser Leu Leu Gln Ser Ala 
        275                 280                 285             


Trp Met Glu Ile Leu Ile Leu Gly Val Val Tyr Arg Ser Leu Ser Phe 
    290                 295                 300                 


Glu Asp Glu Leu Val Tyr Ala Asp Asp Tyr Ile Met Asp Glu Asp Gln 
305                 310                 315                 320 


Ser Lys Leu Ala Gly Leu Leu Asp Leu Asn Asn Ala Ile Leu Gln Leu 
                325                 330                 335     


Val Lys Lys Tyr Lys Ser Met Lys Leu Glu Lys Glu Glu Phe Val Thr 
            340                 345                 350         


Leu Lys Ala Ile Ala Leu Ala Asn Ser Asp Ser Met His Ile Glu Asp 
        355                 360                 365             


Val Glu Ala Val Gln Lys Leu Gln Asp Val Leu His Glu Ala Leu Gln 
    370                 375                 380                 


Asp Tyr Glu Ala Gly Gln His Met Glu Asp Pro Arg Arg Ala Gly Lys 
385                 390                 395                 400 


Met Leu Met Thr Leu Pro Leu Leu Arg Gln Thr Ser Thr Lys Ala Val 
                405                 410                 415     


Gln His Phe Tyr Asn Ile Lys Leu Glu Gly Lys Val Pro Met His Lys 
            420                 425                 430         


Leu Phe Leu Glu Met Leu Glu Ala Lys Val 
        435                 440         


<210>  5
<211>  436
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Asn Lys Asp Arg His Ile Asp Ser Ser Cys Ser Ser Phe Ile 
1               5                   10                  15      


Lys Thr Glu Pro Ser Ser Pro Ala Ser Leu Thr Asp Ser Val Asn His 
            20                  25                  30          


His Ser Pro Gly Gly Ser Ser Asp Ala Ser Gly Ser Tyr Ser Ser Thr 
        35                  40                  45              


Met Asn Gly His Gln Asn Gly Leu Asp Ser Pro Pro Leu Tyr Pro Ser 
    50                  55                  60                  


Ala Pro Ile Leu Gly Gly Ser Gly Pro Val Arg Lys Leu Tyr Asp Asp 
65                  70                  75                  80  


Cys Ser Ser Thr Ile Val Glu Asp Pro Gln Thr Lys Cys Glu Tyr Met 
                85                  90                  95      


Leu Asn Ser Met Pro Lys Arg Leu Cys Leu Val Cys Gly Asp Ile Ala 
            100                 105                 110         


Ser Gly Tyr His Tyr Gly Val Ala Ser Cys Glu Ala Cys Lys Ala Phe 
        115                 120                 125             


Phe Lys Arg Thr Ile Gln Gly Asn Ile Glu Tyr Ser Cys Pro Ala Thr 
    130                 135                 140                 


Asn Glu Cys Glu Ile Thr Lys Arg Arg Arg Lys Ser Cys Gln Ala Cys 
145                 150                 155                 160 


Arg Phe Met Lys Cys Leu Lys Val Gly Met Leu Lys Glu Gly Val Arg 
                165                 170                 175     


Leu Asp Arg Val Arg Gly Gly Arg Gln Lys Tyr Lys Arg Arg Ile Asp 
            180                 185                 190         


Ala Glu Asn Ser Pro Tyr Leu Asn Pro Gln Leu Val Gln Pro Ala Lys 
        195                 200                 205             


Lys Pro Tyr Thr Lys Ile Val Ser His Leu Leu Val Ala Glu Pro Glu 
    210                 215                 220                 


Lys Ile Tyr Ala Met Pro Asp Pro Thr Val Pro Asp Ser Asp Ile Lys 
225                 230                 235                 240 


Ala Leu Thr Thr Leu Cys Asp Leu Ala Asp Arg Glu Leu Val Val Ile 
                245                 250                 255     


Ile Gly Trp Ala Lys His Ile Pro Gly Phe Ser Thr Leu Ser Leu Ala 
            260                 265                 270         


Asp Gln Met Ser Leu Leu Gln Ser Ala Trp Met Glu Ile Leu Ile Leu 
        275                 280                 285             


Gly Val Val Tyr Arg Ser Leu Ser Phe Glu Asp Glu Leu Val Tyr Ala 
    290                 295                 300                 


Asp Asp Tyr Ile Met Asp Glu Asp Gln Ser Lys Leu Ala Gly Leu Leu 
305                 310                 315                 320 


Asp Leu Asn Asn Ala Ile Leu Gln Leu Val Lys Lys Tyr Lys Ser Met 
                325                 330                 335     


Lys Leu Glu Lys Glu Glu Phe Val Thr Leu Lys Ala Ile Ala Leu Ala 
            340                 345                 350         


Asn Ser Asp Ser Met His Ile Glu Asp Val Glu Ala Val Gln Lys Leu 
        355                 360                 365             


Gln Asp Val Leu His Glu Ala Leu Gln Asp Tyr Glu Ala Gly Gln His 
    370                 375                 380                 


Met Glu Asp Pro Arg Arg Ala Gly Lys Met Leu Met Thr Leu Pro Leu 
385                 390                 395                 400 


Leu Arg Gln Thr Ser Thr Lys Ala Val Gln His Phe Tyr Asn Ile Lys 
                405                 410                 415     


Leu Glu Gly Lys Val Pro Met His Lys Leu Phe Leu Glu Met Leu Glu 
            420                 425                 430         


Ala Lys Val Cys 
        435     


<210>  6
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asp Ser Val Glu Leu Cys Leu Pro Glu Ser Phe Ser Leu His Tyr 
1               5                   10                  15      


Glu Glu Glu Leu Leu Cys Arg Met Ser Asn Lys Asp Arg His Ile Asp 
            20                  25                  30          


Ser Ser Cys Ser Ser Phe Ile Lys Thr Glu Pro Ser Ser Pro Ala Ser 
        35                  40                  45              


Leu Thr Asp Ser Val Asn His His Ser Pro Gly Gly Ser Ser Asp Ala 
    50                  55                  60                  


Ser Gly Ser Tyr Ser Ser Thr Met Asn Gly His Gln Asn Gly Leu Asp 
65                  70                  75                  80  


Ser Pro Pro Leu Tyr Pro Ser Ala Pro Ile Leu Gly Gly Ser Gly Pro 
                85                  90                  95      


Val Arg Lys Leu Tyr Asp Asp Cys Ser Ser Thr Ile Val Glu Asp Pro 
            100                 105                 110         


Gln Thr Lys Cys Glu Tyr Met Leu Asn Ser Met Pro Lys Arg Leu Cys 
        115                 120                 125             


Leu Val Cys Gly Asp Ile Ala Ser Gly Tyr His Tyr Gly Val Ala Ser 
    130                 135                 140                 


Cys Glu Ala Cys Lys Ala Phe Phe Lys Arg Thr Ile Gln Gly Asn Ile 
145                 150                 155                 160 


Glu Tyr Ser Cys Pro Ala Thr Asn Glu Cys Glu Ile Thr Lys Arg Arg 
                165                 170                 175     


Arg Lys Ser Cys Gln Ala Cys Arg Phe Met Lys Cys Leu Lys Val Gly 
            180                 185                 190         


Met Leu Lys Glu Gly Val Arg Leu Asp Arg Val Arg Gly Gly Arg Gln 
        195                 200                 205             


Lys Tyr Lys Arg Arg Ile Asp Ala Glu Asn Ser Pro Tyr Leu Asn Pro 
    210                 215                 220                 


Gln Leu Val Gln Pro Ala Lys Lys Pro Tyr Asn Lys Ile Val Ser His 
225                 230                 235                 240 


Leu Leu Val Ala Glu Pro Glu Lys Ile Tyr Ala Met Pro Asp Pro Thr 
                245                 250                 255     


Val Pro Asp Ser Asp Ile Lys Ala Leu Thr Thr Leu Cys Asp Leu Ala 
            260                 265                 270         


Asp Arg Glu Leu Val Val Ile Ile Gly Trp Ala Lys His Ile Pro Gly 
        275                 280                 285             


Phe Ser Thr Leu Ser Leu Ala Asp Gln Met Ser Leu Leu Gln Ser Ala 
    290                 295                 300                 


Trp Met Glu Ile Leu Ile Leu Gly Val Val Tyr Arg Ser Leu Ser Phe 
305                 310                 315                 320 


Glu Asp Glu Leu Val Tyr Ala Asp Asp Tyr Ile Met Asp Glu Asp Gln 
                325                 330                 335     


Ser Lys Leu Ala Gly Leu Leu Asp Leu Asn Asn Ala Ile Leu Gln Leu 
            340                 345                 350         


Val Lys Lys Tyr Lys Ser Met Lys Leu Glu Lys Glu Glu Phe Val Thr 
        355                 360                 365             


Leu Lys Ala Ile Ala Leu Ala Asn Ser Asp Ser Met His Ile Glu Asp 
    370                 375                 380                 


Val Glu Ala Val Gln Lys Leu Gln Asp Val Leu His Glu Ala Leu Gln 
385                 390                 395                 400 


Asp Tyr Glu Ala Gly Gln His Met Glu Asp Pro Arg Arg Ala Gly Lys 
                405                 410                 415     


Met Leu Met Thr Leu Pro Leu Leu Arg Gln Thr Ser Thr Lys Ala Val 
            420                 425                 430         


Gln His Phe Tyr Asn Ile Lys Leu Glu Gly Lys Val Pro Met His Lys 
        435                 440                 445             


Leu Phe Leu Glu Met Leu Glu Ala Lys Val 
    450                 455             


<210>  7
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Asn Lys Asp Arg His Ile Asp Ser Ser Cys Ser Ser Phe Ile 
1               5                   10                  15      


Lys Thr Glu Pro Ser Ser Pro Ala Ser Leu Thr Asp Ser Val Asn His 
            20                  25                  30          


His Ser Pro Gly Gly Ser Ser Asp Ala Ser Gly Ser Tyr Ser Ser Thr 
        35                  40                  45              


Met Asn Gly His Gln Asn Gly Leu Asp Ser Pro Pro Leu Tyr Pro Ser 
    50                  55                  60                  


Ala Pro Ile Leu Gly Gly Ser Gly Pro Val Arg Lys Leu Tyr Asp Asp 
65                  70                  75                  80  


Cys Ser Ser Thr Ile Val Glu Asp Pro Gln Thr Lys Cys Glu Tyr Met 
                85                  90                  95      


Leu Asn Ser Met Pro Lys Arg Leu Cys Leu Val Cys Gly Asp Ile Ala 
            100                 105                 110         


Ser Gly Tyr His Tyr Gly Val Ala Ser Cys Glu Ala Cys Lys Ala Phe 
        115                 120                 125             


Phe Lys Arg Thr Ile Gln Gly Asn Ile Glu Tyr Ser Cys Pro Ala Thr 
    130                 135                 140                 


Asn Glu Cys Glu Ile Thr Lys Arg Arg Arg Lys Ser Cys Gln Ala Cys 
145                 150                 155                 160 


Arg Phe Met Lys Cys Leu Lys Val Gly Met Leu Lys Glu Gly Val Arg 
                165                 170                 175     


Leu Asp Arg Val Arg Gly Gly Arg Gln Lys Tyr Lys Arg Arg Ile Asp 
            180                 185                 190         


Ala Glu Asn Ser Pro Tyr Leu Asn Pro Gln Leu Val Gln Pro Ala Lys 
        195                 200                 205             


Lys Pro Tyr Asn Lys Ile Val Ser His Leu Leu Val Ala Glu Pro Glu 
    210                 215                 220                 


Lys Ile Tyr Ala Met Pro Asp Pro Thr Val Pro Asp Ser Asp Ile Lys 
225                 230                 235                 240 


Ala Leu Thr Thr Leu Cys Asp Leu Ala Asp Arg Glu Leu Val Val Ile 
                245                 250                 255     


Ile Gly Trp Ala Lys His Ile Pro Gly Phe Ser Thr Leu Ser Leu Ala 
            260                 265                 270         


Asp Gln Met Ser Leu Leu Gln Ser Ala Trp Met Glu Ile Leu Ile Leu 
        275                 280                 285             


Gly Val Val Tyr Arg Ser Leu Ser Phe Glu Asp Glu Leu Val Tyr Ala 
    290                 295                 300                 


Asp Asp Tyr Ile Met Asp Glu Asp Gln Ser Lys Leu Ala Gly Leu Leu 
305                 310                 315                 320 


Asp Leu Asn Asn Ala Ile Leu Gln Leu Val Lys Lys Tyr Lys Ser Met 
                325                 330                 335     


Lys Leu Glu Lys Lys Lys Lys 
            340             


<210>  8
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Tyr Gln Ser Leu Ala Met Ala Ala Asn His Gly Pro Pro Pro Gly 
1               5                   10                  15      


Ala Tyr Glu Ala Gly Gly Pro Gly Ala Phe Met His Gly Ala Gly Ala 
            20                  25                  30          


Ala Ser Ser Pro Val Tyr Val Pro Thr Pro Arg Val Pro Ser Ser Val 
        35                  40                  45              


Leu Gly Leu Ser Tyr Leu Gln Gly Gly Gly Ala Gly Ser Ala Ser Gly 
    50                  55                  60                  


Gly Ala Ser Gly Gly Ser Ser Gly Gly Ala Ala Ser Gly Ala Gly Pro 
65                  70                  75                  80  


Gly Thr Gln Gln Gly Ser Pro Gly Trp Ser Gln Ala Gly Ala Asp Gly 
                85                  90                  95      


Ala Ala Tyr Thr Pro Pro Pro Val Ser Pro Arg Phe Ser Phe Pro Gly 
            100                 105                 110         


Thr Thr Gly Ser Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Arg Glu 
        115                 120                 125             


Ala Ala Ala Tyr Ser Ser Gly Gly Gly Ala Ala Gly Ala Gly Leu Ala 
    130                 135                 140                 


Gly Arg Glu Gln Tyr Gly Arg Ala Gly Phe Ala Gly Ser Tyr Ser Ser 
145                 150                 155                 160 


Pro Tyr Pro Ala Tyr Met Ala Asp Val Gly Ala Ser Trp Ala Ala Ala 
                165                 170                 175     


Ala Ala Ala Ser Ala Gly Pro Phe Asp Ser Pro Val Leu His Ser Leu 
            180                 185                 190         


Pro Gly Arg Ala Asn Pro Ala Ala Arg His Pro Asn Leu Asp Met Phe 
        195                 200                 205             


Asp Asp Phe Ser Glu Gly Arg Glu Cys Val Asn Cys Gly Ala Met Ser 
    210                 215                 220                 


Thr Pro Leu Trp Arg Arg Asp Gly Thr Gly His Tyr Leu Cys Asn Ala 
225                 230                 235                 240 


Cys Gly Leu Tyr His Lys Met Asn Gly Ile Asn Arg Pro Leu Ile Lys 
                245                 250                 255     


Pro Gln Arg Arg Leu Ser Ala Ser Arg Arg Val Gly Leu Ser Cys Ala 
            260                 265                 270         


Asn Cys Gln Thr Thr Thr Thr Thr Leu Trp Arg Arg Asn Ala Glu Gly 
        275                 280                 285             


Glu Pro Val Cys Asn Ala Cys Gly Leu Tyr Met Lys Leu His Gly Val 
    290                 295                 300                 


Pro Arg Pro Leu Ala Met Arg Lys Glu Gly Ile Gln Thr Arg Lys Arg 
305                 310                 315                 320 


Lys Pro Lys Asn Leu Asn Lys Ser Lys Thr Pro Ala Ala Pro Ser Gly 
                325                 330                 335     


Ser Glu Ser Leu Pro Pro Ala Ser Gly Ala Ser Ser Asn Ser Ser Asn 
            340                 345                 350         


Ala Thr Thr Ser Ser Ser Glu Glu Met Arg Pro Ile Lys Thr Glu Pro 
        355                 360                 365             


Gly Leu Ser Ser His Tyr Gly His Ser Ser Ser Val Ser Gln Thr Phe 
    370                 375                 380                 


Ser Val Ser Ala Met Ser Gly His Gly Pro Ser Ile His Pro Val Leu 
385                 390                 395                 400 


Ser Ala Leu Lys Leu Ser Pro Gln Gly Tyr Ala Ser Pro Val Ser Gln 
                405                 410                 415     


Ser Pro Gln Thr Ser Ser Lys Gln Asp Ser Trp Asn Ser Leu Val Leu 
            420                 425                 430         


Ala Asp Ser His Gly Asp Ile Ile Thr Ala 
        435                 440         


<210>  9
<211>  1329
<212>  PRT
<213>  Homo sapiens

<400>  9

Ala Thr Gly Thr Ala Thr Cys Ala Gly Ala Gly Cys Thr Thr Gly Gly 
1               5                   10                  15      


Cys Cys Ala Thr Gly Gly Cys Cys Gly Cys Cys Ala Ala Cys Cys Ala 
            20                  25                  30          


Cys Gly Gly Gly Cys Cys Gly Cys Cys Cys Cys Cys Cys Gly Gly Thr 
        35                  40                  45              


Gly Cys Cys Thr Ala Cys Gly Ala Gly Gly Cys Gly Gly Gly Cys Gly 
    50                  55                  60                  


Gly Cys Cys Cys Cys Gly Gly Cys Gly Cys Cys Thr Thr Cys Ala Thr 
65                  70                  75                  80  


Gly Cys Ala Cys Gly Gly Cys Gly Cys Gly Gly Gly Cys Gly Cys Cys 
                85                  90                  95      


Gly Cys Gly Thr Cys Cys Thr Cys Gly Cys Cys Ala Gly Thr Cys Thr 
            100                 105                 110         


Ala Cys Gly Thr Gly Cys Cys Cys Ala Cys Ala Cys Cys Gly Cys Gly 
        115                 120                 125             


Gly Gly Thr Gly Cys Cys Cys Thr Cys Cys Thr Cys Cys Gly Thr Gly 
    130                 135                 140                 


Cys Thr Gly Gly Gly Cys Cys Thr Gly Thr Cys Cys Thr Ala Cys Cys 
145                 150                 155                 160 


Thr Cys Cys Ala Gly Gly Gly Cys Gly Gly Ala Gly Gly Cys Gly Cys 
                165                 170                 175     


Gly Gly Gly Cys Thr Cys Thr Gly Cys Gly Thr Cys Cys Gly Gly Ala 
            180                 185                 190         


Gly Gly Cys Gly Cys Cys Thr Cys Gly Gly Gly Cys Gly Gly Cys Ala 
        195                 200                 205             


Gly Cys Thr Cys Cys Gly Gly Thr Gly Gly Gly Gly Cys Cys Gly Cys 
    210                 215                 220                 


Gly Thr Cys Thr Gly Gly Thr Gly Cys Gly Gly Gly Gly Cys Cys Cys 
225                 230                 235                 240 


Gly Gly Gly Ala Cys Cys Cys Ala Gly Cys Ala Gly Gly Gly Cys Ala 
                245                 250                 255     


Gly Cys Cys Cys Gly Gly Gly Ala Thr Gly Gly Ala Gly Cys Cys Ala 
            260                 265                 270         


Gly Gly Cys Gly Gly Gly Ala Gly Cys Cys Gly Ala Cys Gly Gly Ala 
        275                 280                 285             


Gly Cys Cys Gly Cys Thr Thr Ala Cys Ala Cys Cys Cys Cys Gly Cys 
    290                 295                 300                 


Cys Gly Cys Cys Gly Gly Thr Gly Thr Cys Gly Cys Cys Gly Cys Gly 
305                 310                 315                 320 


Cys Thr Thr Cys Thr Cys Cys Thr Thr Cys Cys Cys Gly Gly Gly Gly 
                325                 330                 335     


Ala Cys Cys Ala Cys Cys Gly Gly Gly Thr Cys Cys Cys Thr Gly Gly 
            340                 345                 350         


Cys Gly Gly Cys Cys Gly Cys Cys Gly Cys Cys Gly Cys Cys Gly Cys 
        355                 360                 365             


Thr Gly Cys Cys Gly Cys Gly Gly Cys Cys Cys Gly Gly Gly Ala Ala 
    370                 375                 380                 


Gly Cys Thr Gly Cys Gly Gly Cys Cys Thr Ala Cys Ala Gly Cys Ala 
385                 390                 395                 400 


Gly Thr Gly Gly Cys Gly Gly Cys Gly Gly Ala Gly Cys Gly Gly Cys 
                405                 410                 415     


Gly Gly Gly Thr Gly Cys Gly Gly Gly Cys Cys Thr Gly Gly Cys Gly 
            420                 425                 430         


Gly Gly Cys Cys Gly Cys Gly Ala Gly Cys Ala Gly Thr Ala Cys Gly 
        435                 440                 445             


Gly Gly Cys Gly Cys Gly Cys Cys Gly Gly Cys Thr Thr Cys Gly Cys 
    450                 455                 460                 


Gly Gly Gly Cys Thr Cys Cys Thr Ala Cys Thr Cys Cys Ala Gly Cys 
465                 470                 475                 480 


Cys Cys Cys Thr Ala Cys Cys Cys Gly Gly Cys Thr Thr Ala Cys Ala 
                485                 490                 495     


Thr Gly Gly Cys Cys Gly Ala Cys Gly Thr Gly Gly Gly Cys Gly Cys 
            500                 505                 510         


Gly Thr Cys Cys Thr Gly Gly Gly Cys Cys Gly Cys Ala Gly Cys Cys 
        515                 520                 525             


Gly Cys Cys Gly Cys Cys Gly Cys Cys Thr Cys Cys Gly Cys Cys Gly 
    530                 535                 540                 


Gly Cys Cys Cys Cys Thr Thr Cys Gly Ala Cys Ala Gly Cys Cys Cys 
545                 550                 555                 560 


Gly Gly Thr Cys Cys Thr Gly Cys Ala Cys Ala Gly Cys Cys Thr Gly 
                565                 570                 575     


Cys Cys Cys Gly Gly Cys Cys Gly Gly Gly Cys Cys Ala Ala Cys Cys 
            580                 585                 590         


Cys Gly Gly Cys Cys Gly Cys Cys Cys Gly Ala Cys Ala Cys Cys Cys 
        595                 600                 605             


Cys Ala Ala Thr Cys Thr Cys Gly Ala Thr Ala Thr Gly Thr Thr Thr 
    610                 615                 620                 


Gly Ala Cys Gly Ala Cys Thr Thr Cys Thr Cys Ala Gly Ala Ala Gly 
625                 630                 635                 640 


Gly Cys Ala Gly Ala Gly Ala Gly Thr Gly Thr Gly Thr Cys Ala Ala 
                645                 650                 655     


Cys Thr Gly Thr Gly Gly Gly Gly Cys Thr Ala Thr Gly Thr Cys Cys 
            660                 665                 670         


Ala Cys Cys Cys Cys Gly Cys Thr Cys Thr Gly Gly Ala Gly Gly Cys 
        675                 680                 685             


Gly Ala Gly Ala Thr Gly Gly Gly Ala Cys Gly Gly Gly Thr Cys Ala 
    690                 695                 700                 


Cys Thr Ala Thr Cys Thr Gly Thr Gly Cys Ala Ala Cys Gly Cys Cys 
705                 710                 715                 720 


Thr Gly Cys Gly Gly Cys Cys Thr Cys Thr Ala Cys Cys Ala Cys Ala 
                725                 730                 735     


Ala Gly Ala Thr Gly Ala Ala Cys Gly Gly Cys Ala Thr Cys Ala Ala 
            740                 745                 750         


Cys Cys Gly Gly Cys Cys Gly Cys Thr Cys Ala Thr Cys Ala Ala Gly 
        755                 760                 765             


Cys Cys Thr Cys Ala Gly Cys Gly Cys Cys Gly Gly Cys Thr Gly Thr 
    770                 775                 780                 


Cys Cys Gly Cys Cys Thr Cys Cys Cys Gly Cys Cys Gly Ala Gly Thr 
785                 790                 795                 800 


Gly Gly Gly Cys Cys Thr Cys Thr Cys Cys Thr Gly Thr Gly Cys Cys 
                805                 810                 815     


Ala Ala Cys Thr Gly Cys Cys Ala Gly Ala Cys Cys Ala Cys Cys Ala 
            820                 825                 830         


Cys Cys Ala Cys Cys Ala Cys Gly Cys Thr Gly Thr Gly Gly Cys Gly 
        835                 840                 845             


Cys Cys Gly Cys Ala Ala Thr Gly Cys Gly Gly Ala Gly Gly Gly Cys 
    850                 855                 860                 


Gly Ala Gly Cys Cys Thr Gly Thr Gly Thr Gly Cys Ala Ala Thr Gly 
865                 870                 875                 880 


Cys Cys Thr Gly Cys Gly Gly Cys Cys Thr Cys Thr Ala Cys Ala Thr 
                885                 890                 895     


Gly Ala Ala Gly Cys Thr Cys Cys Ala Cys Gly Gly Gly Gly Thr Cys 
            900                 905                 910         


Cys Cys Cys Ala Gly Gly Cys Cys Thr Cys Thr Thr Gly Cys Ala Ala 
        915                 920                 925             


Thr Gly Cys Gly Gly Ala Ala Ala Gly Ala Gly Gly Gly Gly Ala Thr 
    930                 935                 940                 


Cys Cys Ala Ala Ala Cys Cys Ala Gly Ala Ala Ala Ala Cys Gly Gly 
945                 950                 955                 960 


Ala Ala Gly Cys Cys Cys Ala Ala Gly Ala Ala Cys Cys Thr Gly Ala 
                965                 970                 975     


Ala Thr Ala Ala Ala Thr Cys Thr Ala Ala Gly Ala Cys Ala Cys Cys 
            980                 985                 990         


Ala Gly Cys Ala Gly Cys Thr Cys  Cys Thr Thr Cys Ala  Gly Gly Cys 
        995                 1000                 1005             


Ala Gly  Thr Gly Ala Gly Ala  Gly Cys Cys Thr Thr  Cys Cys Thr 
    1010                 1015                 1020             


Cys Cys  Cys Gly Cys Cys Ala  Gly Cys Gly Gly Thr  Gly Cys Thr 
    1025                 1030                 1035             


Thr Cys  Cys Ala Gly Cys Ala  Ala Cys Thr Cys Cys  Ala Gly Cys 
    1040                 1045                 1050             


Ala Ala  Cys Gly Cys Cys Ala  Cys Cys Ala Cys Cys  Ala Gly Cys 
    1055                 1060                 1065             


Ala Gly  Cys Ala Gly Cys Gly  Ala Gly Gly Ala Gly  Ala Thr Gly 
    1070                 1075                 1080             


Cys Gly  Thr Cys Cys Cys Ala  Thr Cys Ala Ala Gly  Ala Cys Gly 
    1085                 1090                 1095             


Gly Ala  Gly Cys Cys Thr Gly  Gly Cys Cys Thr Gly  Thr Cys Ala 
    1100                 1105                 1110             


Thr Cys  Thr Cys Ala Cys Thr  Ala Cys Gly Gly Gly  Cys Ala Cys 
    1115                 1120                 1125             


Ala Gly  Cys Ala Gly Cys Thr  Cys Cys Gly Thr Gly  Thr Cys Cys 
    1130                 1135                 1140             


Cys Ala  Gly Ala Cys Gly Thr  Thr Cys Thr Cys Ala  Gly Thr Cys 
    1145                 1150                 1155             


Ala Gly  Thr Gly Cys Gly Ala  Thr Gly Thr Cys Thr  Gly Gly Cys 
    1160                 1165                 1170             


Cys Ala  Thr Gly Gly Gly Cys  Cys Cys Thr Cys Cys  Ala Thr Cys 
    1175                 1180                 1185             


Cys Ala  Cys Cys Cys Thr Gly  Thr Cys Cys Thr Cys  Thr Cys Gly 
    1190                 1195                 1200             


Gly Cys  Cys Cys Thr Gly Ala  Ala Gly Cys Thr Cys  Thr Cys Cys 
    1205                 1210                 1215             


Cys Cys  Ala Cys Ala Ala Gly  Gly Cys Thr Ala Thr  Gly Cys Gly 
    1220                 1225                 1230             


Thr Cys  Thr Cys Cys Cys Gly  Thr Cys Ala Gly Cys  Cys Ala Gly 
    1235                 1240                 1245             


Thr Cys  Thr Cys Cys Ala Cys  Ala Gly Ala Cys Cys  Ala Gly Cys 
    1250                 1255                 1260             


Thr Cys  Cys Ala Ala Gly Cys  Ala Gly Gly Ala Cys  Thr Cys Thr 
    1265                 1270                 1275             


Thr Gly  Gly Ala Ala Cys Ala  Gly Cys Cys Thr Gly  Gly Thr Cys 
    1280                 1285                 1290             


Thr Thr  Gly Gly Cys Cys Gly  Ala Cys Ala Gly Thr  Cys Ala Cys 
    1295                 1300                 1305             


Gly Gly  Gly Gly Ala Cys Ala  Thr Ala Ala Thr Cys  Ala Cys Thr 
    1310                 1315                 1320             


Gly Cys  Gly Thr Ala Ala 
    1325                 


<210>  10
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gly Arg Lys Lys Ile Gln Ile Thr Arg Ile Met Asp Glu Arg Asn 
1               5                   10                  15      


Arg Gln Val Thr Phe Thr Lys Arg Lys Phe Gly Leu Met Lys Lys Ala 
            20                  25                  30          


Tyr Glu Leu Ser Val Leu Cys Asp Cys Glu Ile Ala Leu Ile Ile Phe 
        35                  40                  45              


Asn Ser Thr Asn Lys Leu Phe Gln Tyr Ala Ser Thr Asp Met Asp Lys 
    50                  55                  60                  


Val Leu Leu Lys Tyr Thr Glu Tyr Asn Glu Pro His Glu Ser Arg Thr 
65                  70                  75                  80  


Asn Ser Asp Ile Val Glu Ala Leu Asn Lys Lys Glu Asn Lys Gly Cys 
                85                  90                  95      


Glu Ser Pro Asp Pro Asp Ser Ser Tyr Ala Leu Thr Pro Arg Thr Glu 
            100                 105                 110         


Glu Lys Tyr Lys Lys Ile Asn Glu Glu Phe Asp Asn Met Ile Lys Ser 
        115                 120                 125             


His Lys Ile Pro Ala Val Pro Pro Pro Asn Phe Glu Met Pro Val Ser 
    130                 135                 140                 


Ile Pro Val Ser Ser His Asn Ser Leu Val Tyr Ser Asn Pro Val Ser 
145                 150                 155                 160 


Ser Leu Gly Asn Pro Asn Leu Leu Pro Leu Ala His Pro Ser Leu Gln 
                165                 170                 175     


Arg Asn Ser Met Ser Pro Gly Val Thr His Arg Pro Pro Ser Ala Gly 
            180                 185                 190         


Asn Thr Gly Gly Leu Met Gly Gly Asp Leu Thr Ser Gly Ala Gly Thr 
        195                 200                 205             


Ser Ala Gly Asn Gly Tyr Gly Asn Pro Arg Asn Ser Pro Gly Leu Leu 
    210                 215                 220                 


Val Ser Pro Gly Asn Leu Asn Lys Asn Met Gln Ala Lys Ser Pro Pro 
225                 230                 235                 240 


Pro Met Asn Leu Gly Met Asn Asn Arg Lys Pro Asp Leu Arg Val Leu 
                245                 250                 255     


Ile Pro Pro Gly Ser Lys Asn Thr Met Pro Ser Val Asn Gln Arg Ile 
            260                 265                 270         


Asn Asn Ser Gln Ser Ala Gln Ser Leu Ala Thr Pro Val Val Ser Val 
        275                 280                 285             


Ala Thr Pro Thr Leu Pro Gly Gln Gly Met Gly Gly Tyr Pro Ser Ala 
    290                 295                 300                 


Ile Ser Thr Thr Tyr Gly Thr Glu Tyr Ser Leu Ser Ser Ala Asp Leu 
305                 310                 315                 320 


Ser Ser Leu Ser Gly Phe Asn Thr Ala Ser Ala Leu His Leu Gly Ser 
                325                 330                 335     


Val Thr Gly Trp Gln Gln Gln His Leu His Asn Met Pro Pro Ser Ala 
            340                 345                 350         


Leu Ser Gln Leu Gly Ala Cys Thr Ser Thr His Leu Ser Gln Ser Ser 
        355                 360                 365             


Asn Leu Ser Leu Pro Ser Thr Gln Ser Leu Asn Ile Lys Ser Glu Pro 
    370                 375                 380                 


Val Ser Pro Pro Arg Asp Arg Thr Thr Thr Pro Ser Arg Tyr Pro Gln 
385                 390                 395                 400 


His Thr Arg His Glu Ala Gly Arg Ser Pro Val Asp Ser Leu Ser Ser 
                405                 410                 415     


Cys Ser Ser Ser Tyr Asp Gly Ser Asp Arg Glu Asp His Arg Asn Glu 
            420                 425                 430         


Phe His Ser Pro Ile Gly Leu Thr Arg Pro Ser Pro Asp Glu Arg Glu 
        435                 440                 445             


Ser Pro Ser Val Lys Arg Met Arg Leu Ser Glu Gly Trp Ala Thr 
    450                 455                 460             


<210>  11
<211>  1392
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala Thr Gly Gly Gly Gly Ala Gly Ala Ala Ala Ala Ala Ala Gly Ala 
1               5                   10                  15      


Thr Thr Cys Ala Gly Ala Thr Thr Ala Cys Gly Ala Gly Gly Ala Thr 
            20                  25                  30          


Thr Ala Thr Gly Gly Ala Thr Gly Ala Ala Cys Gly Thr Ala Ala Cys 
        35                  40                  45              


Ala Gly Ala Cys Ala Gly Gly Thr Gly Ala Cys Ala Thr Thr Thr Ala 
    50                  55                  60                  


Cys Ala Ala Ala Gly Ala Gly Gly Ala Ala Ala Thr Thr Thr Gly Gly 
65                  70                  75                  80  


Gly Thr Thr Gly Ala Thr Gly Ala Ala Gly Ala Ala Gly Gly Cys Thr 
                85                  90                  95      


Thr Ala Thr Gly Ala Gly Cys Thr Gly Ala Gly Cys Gly Thr Gly Cys 
            100                 105                 110         


Thr Gly Thr Gly Thr Gly Ala Cys Thr Gly Thr Gly Ala Gly Ala Thr 
        115                 120                 125             


Thr Gly Cys Gly Cys Thr Gly Ala Thr Cys Ala Thr Cys Thr Thr Cys 
    130                 135                 140                 


Ala Ala Cys Ala Gly Cys Ala Cys Cys Ala Ala Cys Ala Ala Gly Cys 
145                 150                 155                 160 


Thr Gly Thr Thr Cys Cys Ala Gly Thr Ala Thr Gly Cys Cys Ala Gly 
                165                 170                 175     


Cys Ala Cys Cys Gly Ala Cys Ala Thr Gly Gly Ala Cys Ala Ala Ala 
            180                 185                 190         


Gly Thr Gly Cys Thr Thr Cys Thr Cys Ala Ala Gly Thr Ala Cys Ala 
        195                 200                 205             


Cys Gly Gly Ala Gly Thr Ala Cys Ala Ala Cys Gly Ala Gly Cys Cys 
    210                 215                 220                 


Gly Cys Ala Thr Gly Ala Gly Ala Gly Cys Cys Gly Gly Ala Cys Ala 
225                 230                 235                 240 


Ala Ala Cys Thr Cys Ala Gly Ala Cys Ala Thr Cys Gly Thr Gly Gly 
                245                 250                 255     


Ala Gly Gly Cys Ala Thr Thr Gly Ala Ala Cys Ala Ala Gly Ala Ala 
            260                 265                 270         


Ala Gly Ala Ala Ala Ala Cys Ala Ala Ala Gly Gly Cys Thr Gly Thr 
        275                 280                 285             


Gly Ala Ala Ala Gly Cys Cys Cys Cys Gly Ala Thr Cys Cys Cys Gly 
    290                 295                 300                 


Ala Cys Thr Cys Cys Thr Cys Thr Thr Ala Thr Gly Cys Ala Cys Thr 
305                 310                 315                 320 


Cys Ala Cys Cys Cys Cys Ala Cys Gly Cys Ala Cys Thr Gly Ala Ala 
                325                 330                 335     


Gly Ala Ala Ala Ala Ala Thr Ala Cys Ala Ala Ala Ala Ala Ala Ala 
            340                 345                 350         


Thr Thr Ala Ala Thr Gly Ala Ala Gly Ala Ala Thr Thr Thr Gly Ala 
        355                 360                 365             


Thr Ala Ala Thr Ala Thr Gly Ala Thr Cys Ala Ala Gly Ala Gly Thr 
    370                 375                 380                 


Cys Ala Thr Ala Ala Ala Ala Thr Thr Cys Cys Thr Gly Cys Thr Gly 
385                 390                 395                 400 


Thr Thr Cys Cys Ala Cys Cys Thr Cys Cys Cys Ala Ala Cys Thr Thr 
                405                 410                 415     


Cys Gly Ala Gly Ala Thr Gly Cys Cys Ala Gly Thr Cys Thr Cys Cys 
            420                 425                 430         


Ala Thr Cys Cys Cys Ala Gly Thr Gly Thr Cys Cys Ala Gly Cys Cys 
        435                 440                 445             


Ala Cys Ala Ala Cys Ala Gly Thr Thr Thr Gly Gly Thr Gly Thr Ala 
    450                 455                 460                 


Cys Ala Gly Cys Ala Ala Cys Cys Cys Thr Gly Thr Cys Ala Gly Cys 
465                 470                 475                 480 


Thr Cys Ala Cys Thr Gly Gly Gly Ala Ala Ala Cys Cys Cys Cys Ala 
                485                 490                 495     


Ala Cys Cys Thr Ala Thr Thr Gly Cys Cys Ala Cys Thr Gly Gly Cys 
            500                 505                 510         


Thr Cys Ala Cys Cys Cys Thr Thr Cys Thr Cys Thr Gly Cys Ala Gly 
        515                 520                 525             


Ala Gly Gly Ala Ala Thr Ala Gly Thr Ala Thr Gly Thr Cys Thr Cys 
    530                 535                 540                 


Cys Thr Gly Gly Thr Gly Thr Ala Ala Cys Ala Cys Ala Thr Cys Gly 
545                 550                 555                 560 


Ala Cys Cys Thr Cys Cys Ala Ala Gly Thr Gly Cys Ala Gly Gly Thr 
                565                 570                 575     


Ala Ala Cys Ala Cys Ala Gly Gly Thr Gly Gly Thr Cys Thr Gly Ala 
            580                 585                 590         


Thr Gly Gly Gly Thr Gly Gly Ala Gly Ala Cys Cys Thr Cys Ala Cys 
        595                 600                 605             


Gly Thr Cys Thr Gly Gly Thr Gly Cys Ala Gly Gly Cys Ala Cys Cys 
    610                 615                 620                 


Ala Gly Thr Gly Cys Ala Gly Gly Gly Ala Ala Cys Gly Gly Gly Thr 
625                 630                 635                 640 


Ala Thr Gly Gly Cys Ala Ala Thr Cys Cys Cys Cys Gly Ala Ala Ala 
                645                 650                 655     


Cys Thr Cys Ala Cys Cys Ala Gly Gly Thr Cys Thr Gly Cys Thr Gly 
            660                 665                 670         


Gly Thr Cys Thr Cys Ala Cys Cys Thr Gly Gly Thr Ala Ala Cys Thr 
        675                 680                 685             


Thr Gly Ala Ala Cys Ala Ala Gly Ala Ala Thr Ala Thr Gly Cys Ala 
    690                 695                 700                 


Ala Gly Cys Ala Ala Ala Ala Thr Cys Thr Cys Cys Thr Cys Cys Cys 
705                 710                 715                 720 


Cys Cys Ala Ala Thr Gly Ala Ala Thr Thr Thr Ala Gly Gly Ala Ala 
                725                 730                 735     


Thr Gly Ala Ala Thr Ala Ala Cys Cys Gly Thr Ala Ala Ala Cys Cys 
            740                 745                 750         


Ala Gly Ala Thr Cys Thr Cys Cys Gly Ala Gly Thr Thr Cys Thr Thr 
        755                 760                 765             


Ala Thr Thr Cys Cys Ala Cys Cys Ala Gly Gly Cys Ala Gly Cys Ala 
    770                 775                 780                 


Ala Gly Ala Ala Thr Ala Cys Gly Ala Thr Gly Cys Cys Ala Thr Cys 
785                 790                 795                 800 


Ala Gly Thr Gly Ala Ala Thr Cys Ala Ala Ala Gly Gly Ala Thr Ala 
                805                 810                 815     


Ala Ala Thr Ala Ala Cys Thr Cys Cys Cys Ala Gly Thr Cys Gly Gly 
            820                 825                 830         


Cys Thr Cys Ala Gly Thr Cys Ala Thr Thr Gly Gly Cys Thr Ala Cys 
        835                 840                 845             


Cys Cys Cys Ala Gly Thr Gly Gly Thr Thr Thr Cys Cys Gly Thr Ala 
    850                 855                 860                 


Gly Cys Ala Ala Cys Thr Cys Cys Thr Ala Cys Thr Thr Thr Ala Cys 
865                 870                 875                 880 


Cys Ala Gly Gly Ala Cys Ala Ala Gly Gly Ala Ala Thr Gly Gly Gly 
                885                 890                 895     


Ala Gly Gly Ala Thr Ala Thr Cys Cys Ala Thr Cys Ala Gly Cys Cys 
            900                 905                 910         


Ala Thr Thr Thr Cys Ala Ala Cys Ala Ala Cys Ala Thr Ala Thr Gly 
        915                 920                 925             


Gly Thr Ala Cys Cys Gly Ala Gly Thr Ala Cys Thr Cys Thr Cys Thr 
    930                 935                 940                 


Gly Ala Gly Thr Ala Gly Thr Gly Cys Ala Gly Ala Cys Cys Thr Gly 
945                 950                 955                 960 


Thr Cys Ala Thr Cys Thr Cys Thr Gly Thr Cys Thr Gly Gly Gly Thr 
                965                 970                 975     


Thr Thr Ala Ala Cys Ala Cys Cys Gly Cys Cys Ala Gly Cys Gly Cys 
            980                 985                 990         


Thr Cys Thr Thr Cys Ala Cys Cys  Thr Thr Gly Gly Thr  Thr Cys Ala 
        995                 1000                 1005             


Gly Thr  Ala Ala Cys Thr Gly  Gly Cys Thr Gly Gly  Cys Ala Ala 
    1010                 1015                 1020             


Cys Ala  Gly Cys Ala Ala Cys  Ala Cys Cys Thr Ala  Cys Ala Thr 
    1025                 1030                 1035             


Ala Ala  Cys Ala Thr Gly Cys  Cys Ala Cys Cys Ala  Thr Cys Thr 
    1040                 1045                 1050             


Gly Cys  Cys Cys Thr Cys Ala  Gly Thr Cys Ala Gly  Thr Thr Gly 
    1055                 1060                 1065             


Gly Gly  Ala Gly Cys Thr Thr  Gly Cys Ala Cys Thr  Ala Gly Cys 
    1070                 1075                 1080             


Ala Cys  Thr Cys Ala Thr Thr  Thr Ala Thr Cys Thr  Cys Ala Gly 
    1085                 1090                 1095             


Ala Gly  Thr Thr Cys Ala Ala  Ala Thr Cys Thr Cys  Thr Cys Cys 
    1100                 1105                 1110             


Cys Thr  Gly Cys Cys Thr Thr  Cys Thr Ala Cys Thr  Cys Ala Ala 
    1115                 1120                 1125             


Ala Gly  Cys Cys Thr Cys Ala  Ala Cys Ala Thr Cys  Ala Ala Gly 
    1130                 1135                 1140             


Thr Cys  Ala Gly Ala Ala Cys  Cys Thr Gly Thr Thr  Thr Cys Thr 
    1145                 1150                 1155             


Cys Cys  Thr Cys Cys Thr Ala  Gly Ala Gly Ala Cys  Cys Gly Thr 
    1160                 1165                 1170             


Ala Cys  Cys Ala Cys Cys Ala  Cys Cys Cys Cys Thr  Thr Cys Gly 
    1175                 1180                 1185             


Ala Gly  Ala Thr Ala Cys Cys  Cys Ala Cys Ala Ala  Cys Ala Cys 
    1190                 1195                 1200             


Ala Cys  Gly Cys Gly Cys Cys  Ala Cys Gly Ala Gly  Gly Cys Gly 
    1205                 1210                 1215             


Gly Gly  Gly Ala Gly Ala Thr  Cys Thr Cys Cys Thr  Gly Thr Thr 
    1220                 1225                 1230             


Gly Ala  Cys Ala Gly Cys Thr  Thr Gly Ala Gly Cys  Ala Gly Cys 
    1235                 1240                 1245             


Thr Gly  Thr Ala Gly Cys Ala  Gly Thr Thr Cys Gly  Thr Ala Cys 
    1250                 1255                 1260             


Gly Ala  Cys Gly Gly Gly Ala  Gly Cys Gly Ala Cys  Cys Gly Ala 
    1265                 1270                 1275             


Gly Ala  Gly Gly Ala Thr Cys  Ala Cys Cys Gly Gly  Ala Ala Cys 
    1280                 1285                 1290             


Gly Ala  Ala Thr Thr Cys Cys  Ala Cys Thr Cys Cys  Cys Cys Cys 
    1295                 1300                 1305             


Ala Thr  Thr Gly Gly Ala Cys  Thr Cys Ala Cys Cys  Ala Gly Ala 
    1310                 1315                 1320             


Cys Cys  Thr Thr Cys Gly Cys  Cys Gly Gly Ala Cys  Gly Ala Ala 
    1325                 1330                 1335             


Ala Gly  Gly Gly Ala Ala Ala  Gly Thr Cys Cys Cys  Thr Cys Ala 
    1340                 1345                 1350             


Gly Thr  Cys Ala Ala Gly Cys  Gly Cys Ala Thr Gly  Cys Gly Ala 
    1355                 1360                 1365             


Cys Thr  Thr Thr Cys Thr Gly  Ala Ala Gly Gly Ala  Thr Gly Gly 
    1370                 1375                 1380             


Gly Cys  Ala Ala Cys Ala Thr  Gly Ala 
    1385                 1390         


<210>  12
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gly Arg Lys Lys Ile Gln Ile Thr Arg Ile Met Asp Glu Arg Asn 
1               5                   10                  15      


Arg Gln Val Thr Phe Thr Lys Arg Lys Phe Gly Leu Met Lys Lys Ala 
            20                  25                  30          


Tyr Glu Leu Ser Val Leu Cys Asp Cys Glu Ile Ala Leu Ile Ile Phe 
        35                  40                  45              


Asn Ser Thr Asn Lys Leu Phe Gln Tyr Ala Ser Thr Asp Met Asp Lys 
    50                  55                  60                  


Val Leu Leu Lys Tyr Thr Glu Tyr Asn Glu Pro His Glu Ser Arg Thr 
65                  70                  75                  80  


Asn Ser Asp Ile Val Glu Thr Leu Arg Lys Lys Gly Leu Asn Gly Cys 
                85                  90                  95      


Asp Ser Pro Asp Pro Asp Ala Asp Asp Ser Val Gly His Ser Pro Glu 
            100                 105                 110         


Ser Glu Asp Lys Tyr Arg Lys Ile Asn Glu Asp Ile Asp Leu Met Ile 
        115                 120                 125             


Ser Arg Gln Arg Leu Cys Ala Val Pro Pro Pro Asn Phe Glu Met Pro 
    130                 135                 140                 


Val Ser Ile Pro Val Ser Ser His Asn Ser Leu Val Tyr Ser Asn Pro 
145                 150                 155                 160 


Val Ser Ser Leu Gly Asn Pro Asn Leu Leu Pro Leu Ala His Pro Ser 
                165                 170                 175     


Leu Gln Arg Asn Ser Met Ser Pro Gly Val Thr His Arg Pro Pro Ser 
            180                 185                 190         


Ala Gly Asn Thr Gly Gly Leu Met Gly Gly Asp Leu Thr Ser Gly Ala 
        195                 200                 205             


Gly Thr Ser Ala Gly Asn Gly Tyr Gly Asn Pro Arg Asn Ser Pro Gly 
    210                 215                 220                 


Leu Leu Val Ser Pro Gly Asn Leu Asn Lys Asn Met Gln Ala Lys Ser 
225                 230                 235                 240 


Pro Pro Pro Met Asn Leu Gly Met Asn Asn Arg Lys Pro Asp Leu Arg 
                245                 250                 255     


Val Leu Ile Pro Pro Gly Ser Lys Asn Thr Met Pro Ser Val Ser Glu 
            260                 265                 270         


Asp Val Asp Leu Leu Leu Asn Gln Arg Ile Asn Asn Ser Gln Ser Ala 
        275                 280                 285             


Gln Ser Leu Ala Thr Pro Val Val Ser Val Ala Thr Pro Thr Leu Pro 
    290                 295                 300                 


Gly Gln Gly Met Gly Gly Tyr Pro Ser Ala Ile Ser Thr Thr Tyr Gly 
305                 310                 315                 320 


Thr Glu Tyr Ser Leu Ser Ser Ala Asp Leu Ser Ser Leu Ser Gly Phe 
                325                 330                 335     


Asn Thr Ala Ser Ala Leu His Leu Gly Ser Val Thr Gly Trp Gln Gln 
            340                 345                 350         


Gln His Leu His Asn Met Pro Pro Ser Ala Leu Ser Gln Leu Gly Ala 
        355                 360                 365             


Cys Thr Ser Thr His Leu Ser Gln Ser Ser Asn Leu Ser Leu Pro Ser 
    370                 375                 380                 


Thr Gln Ser Leu Asn Ile Lys Ser Glu Pro Val Ser Pro Pro Arg Asp 
385                 390                 395                 400 


Arg Thr Thr Thr Pro Ser Arg Tyr Pro Gln His Thr Arg His Glu Ala 
                405                 410                 415     


Gly Arg Ser Pro Val Asp Ser Leu Ser Ser Cys Ser Ser Ser Tyr Asp 
            420                 425                 430         


Gly Ser Asp Arg Glu Asp His Arg Asn Glu Phe His Ser Pro Ile Gly 
        435                 440                 445             


Leu Thr Arg Pro Ser Pro Asp Glu Arg Glu Ser Pro Ser Val Lys Arg 
    450                 455                 460                 


Met Arg Leu Ser Glu Gly Trp Ala Thr 
465                 470             


<210>  13
<211>  1422
<212>  PRT
<213>  Homo sapiens

<400>  13

Ala Thr Gly Gly Gly Gly Ala Gly Ala Ala Ala Ala Ala Ala Gly Ala 
1               5                   10                  15      


Thr Thr Cys Ala Gly Ala Thr Thr Ala Cys Gly Ala Gly Gly Ala Thr 
            20                  25                  30          


Thr Ala Thr Gly Gly Ala Thr Gly Ala Ala Cys Gly Thr Ala Ala Cys 
        35                  40                  45              


Ala Gly Ala Cys Ala Gly Gly Thr Gly Ala Cys Ala Thr Thr Thr Ala 
    50                  55                  60                  


Cys Ala Ala Ala Gly Ala Gly Gly Ala Ala Ala Thr Thr Thr Gly Gly 
65                  70                  75                  80  


Gly Thr Thr Gly Ala Thr Gly Ala Ala Gly Ala Ala Gly Gly Cys Thr 
                85                  90                  95      


Thr Ala Thr Gly Ala Gly Cys Thr Gly Ala Gly Cys Gly Thr Gly Cys 
            100                 105                 110         


Thr Gly Thr Gly Thr Gly Ala Cys Thr Gly Thr Gly Ala Gly Ala Thr 
        115                 120                 125             


Thr Gly Cys Gly Cys Thr Gly Ala Thr Cys Ala Thr Cys Thr Thr Cys 
    130                 135                 140                 


Ala Ala Cys Ala Gly Cys Ala Cys Cys Ala Ala Cys Ala Ala Gly Cys 
145                 150                 155                 160 


Thr Gly Thr Thr Cys Cys Ala Gly Thr Ala Thr Gly Cys Cys Ala Gly 
                165                 170                 175     


Cys Ala Cys Cys Gly Ala Cys Ala Thr Gly Gly Ala Cys Ala Ala Ala 
            180                 185                 190         


Gly Thr Gly Cys Thr Thr Cys Thr Cys Ala Ala Gly Thr Ala Cys Ala 
        195                 200                 205             


Cys Gly Gly Ala Gly Thr Ala Cys Ala Ala Cys Gly Ala Gly Cys Cys 
    210                 215                 220                 


Gly Cys Ala Thr Gly Ala Gly Ala Gly Cys Cys Gly Gly Ala Cys Ala 
225                 230                 235                 240 


Ala Ala Cys Thr Cys Ala Gly Ala Cys Ala Thr Cys Gly Thr Gly Gly 
                245                 250                 255     


Ala Gly Ala Cys Gly Thr Thr Gly Ala Gly Ala Ala Ala Gly Ala Ala 
            260                 265                 270         


Gly Gly Gly Cys Cys Thr Thr Ala Ala Thr Gly Gly Cys Thr Gly Thr 
        275                 280                 285             


Gly Ala Cys Ala Gly Cys Cys Cys Ala Gly Ala Cys Cys Cys Cys Gly 
    290                 295                 300                 


Ala Thr Gly Cys Gly Gly Ala Cys Gly Ala Thr Thr Cys Cys Gly Thr 
305                 310                 315                 320 


Ala Gly Gly Thr Cys Ala Cys Ala Gly Cys Cys Cys Thr Gly Ala Gly 
                325                 330                 335     


Thr Cys Thr Gly Ala Gly Gly Ala Cys Ala Ala Gly Thr Ala Cys Ala 
            340                 345                 350         


Gly Gly Ala Ala Ala Ala Thr Thr Ala Ala Cys Gly Ala Ala Gly Ala 
        355                 360                 365             


Thr Ala Thr Thr Gly Ala Thr Cys Thr Ala Ala Thr Gly Ala Thr Cys 
    370                 375                 380                 


Ala Gly Cys Ala Gly Gly Cys Ala Ala Ala Gly Ala Thr Thr Gly Thr 
385                 390                 395                 400 


Gly Thr Gly Cys Thr Gly Thr Thr Cys Cys Ala Cys Cys Thr Cys Cys 
                405                 410                 415     


Cys Ala Ala Cys Thr Thr Cys Gly Ala Gly Ala Thr Gly Cys Cys Ala 
            420                 425                 430         


Gly Thr Cys Thr Cys Cys Ala Thr Cys Cys Cys Ala Gly Thr Gly Thr 
        435                 440                 445             


Cys Cys Ala Gly Cys Cys Ala Cys Ala Ala Cys Ala Gly Thr Thr Thr 
    450                 455                 460                 


Gly Gly Thr Gly Thr Ala Cys Ala Gly Cys Ala Ala Cys Cys Cys Thr 
465                 470                 475                 480 


Gly Thr Cys Ala Gly Cys Thr Cys Ala Cys Thr Gly Gly Gly Ala Ala 
                485                 490                 495     


Ala Cys Cys Cys Cys Ala Ala Cys Cys Thr Ala Thr Thr Gly Cys Cys 
            500                 505                 510         


Ala Cys Thr Gly Gly Cys Thr Cys Ala Cys Cys Cys Thr Thr Cys Thr 
        515                 520                 525             


Cys Thr Gly Cys Ala Gly Ala Gly Gly Ala Ala Thr Ala Gly Thr Ala 
    530                 535                 540                 


Thr Gly Thr Cys Thr Cys Cys Thr Gly Gly Thr Gly Thr Ala Ala Cys 
545                 550                 555                 560 


Ala Cys Ala Thr Cys Gly Ala Cys Cys Thr Cys Cys Ala Ala Gly Thr 
                565                 570                 575     


Gly Cys Ala Gly Gly Thr Ala Ala Cys Ala Cys Ala Gly Gly Thr Gly 
            580                 585                 590         


Gly Thr Cys Thr Gly Ala Thr Gly Gly Gly Thr Gly Gly Ala Gly Ala 
        595                 600                 605             


Cys Cys Thr Cys Ala Cys Gly Thr Cys Thr Gly Gly Thr Gly Cys Ala 
    610                 615                 620                 


Gly Gly Cys Ala Cys Cys Ala Gly Thr Gly Cys Ala Gly Gly Gly Ala 
625                 630                 635                 640 


Ala Cys Gly Gly Gly Thr Ala Thr Gly Gly Cys Ala Ala Thr Cys Cys 
                645                 650                 655     


Cys Cys Gly Ala Ala Ala Cys Thr Cys Ala Cys Cys Ala Gly Gly Thr 
            660                 665                 670         


Cys Thr Gly Cys Thr Gly Gly Thr Cys Thr Cys Ala Cys Cys Thr Gly 
        675                 680                 685             


Gly Thr Ala Ala Cys Thr Thr Gly Ala Ala Cys Ala Ala Gly Ala Ala 
    690                 695                 700                 


Thr Ala Thr Gly Cys Ala Ala Gly Cys Ala Ala Ala Ala Thr Cys Thr 
705                 710                 715                 720 


Cys Cys Thr Cys Cys Cys Cys Cys Ala Ala Thr Gly Ala Ala Thr Thr 
                725                 730                 735     


Thr Ala Gly Gly Ala Ala Thr Gly Ala Ala Thr Ala Ala Cys Cys Gly 
            740                 745                 750         


Thr Ala Ala Ala Cys Cys Ala Gly Ala Thr Cys Thr Cys Cys Gly Ala 
        755                 760                 765             


Gly Thr Thr Cys Thr Thr Ala Thr Thr Cys Cys Ala Cys Cys Ala Gly 
    770                 775                 780                 


Gly Cys Ala Gly Cys Ala Ala Gly Ala Ala Thr Ala Cys Gly Ala Thr 
785                 790                 795                 800 


Gly Cys Cys Ala Thr Cys Ala Gly Thr Gly Thr Cys Thr Gly Ala Gly 
                805                 810                 815     


Gly Ala Thr Gly Thr Cys Gly Ala Cys Cys Thr Gly Cys Thr Thr Thr 
            820                 825                 830         


Thr Gly Ala Ala Thr Cys Ala Ala Ala Gly Gly Ala Thr Ala Ala Ala 
        835                 840                 845             


Thr Ala Ala Cys Thr Cys Cys Cys Ala Gly Thr Cys Gly Gly Cys Thr 
    850                 855                 860                 


Cys Ala Gly Thr Cys Ala Thr Thr Gly Gly Cys Thr Ala Cys Cys Cys 
865                 870                 875                 880 


Cys Ala Gly Thr Gly Gly Thr Thr Thr Cys Cys Gly Thr Ala Gly Cys 
                885                 890                 895     


Ala Ala Cys Thr Cys Cys Thr Ala Cys Thr Thr Thr Ala Cys Cys Ala 
            900                 905                 910         


Gly Gly Ala Cys Ala Ala Gly Gly Ala Ala Thr Gly Gly Gly Ala Gly 
        915                 920                 925             


Gly Ala Thr Ala Thr Cys Cys Ala Thr Cys Ala Gly Cys Cys Ala Thr 
    930                 935                 940                 


Thr Thr Cys Ala Ala Cys Ala Ala Cys Ala Thr Ala Thr Gly Gly Thr 
945                 950                 955                 960 


Ala Cys Cys Gly Ala Gly Thr Ala Cys Thr Cys Thr Cys Thr Gly Ala 
                965                 970                 975     


Gly Thr Ala Gly Thr Gly Cys Ala Gly Ala Cys Cys Thr Gly Thr Cys 
            980                 985                 990         


Ala Thr Cys Thr Cys Thr Gly Thr  Cys Thr Gly Gly Gly  Thr Thr Thr 
        995                 1000                 1005             


Ala Ala  Cys Ala Cys Cys Gly  Cys Cys Ala Gly Cys  Gly Cys Thr 
    1010                 1015                 1020             


Cys Thr  Thr Cys Ala Cys Cys  Thr Thr Gly Gly Thr  Thr Cys Ala 
    1025                 1030                 1035             


Gly Thr  Ala Ala Cys Thr Gly  Gly Cys Thr Gly Gly  Cys Ala Ala 
    1040                 1045                 1050             


Cys Ala  Gly Cys Ala Ala Cys  Ala Cys Cys Thr Ala  Cys Ala Thr 
    1055                 1060                 1065             


Ala Ala  Cys Ala Thr Gly Cys  Cys Ala Cys Cys Ala  Thr Cys Thr 
    1070                 1075                 1080             


Gly Cys  Cys Cys Thr Cys Ala  Gly Thr Cys Ala Gly  Thr Thr Gly 
    1085                 1090                 1095             


Gly Gly  Ala Gly Cys Thr Thr  Gly Cys Ala Cys Thr  Ala Gly Cys 
    1100                 1105                 1110             


Ala Cys  Thr Cys Ala Thr Thr  Thr Ala Thr Cys Thr  Cys Ala Gly 
    1115                 1120                 1125             


Ala Gly  Thr Thr Cys Ala Ala  Ala Thr Cys Thr Cys  Thr Cys Cys 
    1130                 1135                 1140             


Cys Thr  Gly Cys Cys Thr Thr  Cys Thr Ala Cys Thr  Cys Ala Ala 
    1145                 1150                 1155             


Ala Gly  Cys Cys Thr Cys Ala  Ala Cys Ala Thr Cys  Ala Ala Gly 
    1160                 1165                 1170             


Thr Cys  Ala Gly Ala Ala Cys  Cys Thr Gly Thr Thr  Thr Cys Thr 
    1175                 1180                 1185             


Cys Cys  Thr Cys Cys Thr Ala  Gly Ala Gly Ala Cys  Cys Gly Thr 
    1190                 1195                 1200             


Ala Cys  Cys Ala Cys Cys Ala  Cys Cys Cys Cys Thr  Thr Cys Gly 
    1205                 1210                 1215             


Ala Gly  Ala Thr Ala Cys Cys  Cys Ala Cys Ala Ala  Cys Ala Cys 
    1220                 1225                 1230             


Ala Cys  Gly Cys Gly Cys Cys  Ala Cys Gly Ala Gly  Gly Cys Gly 
    1235                 1240                 1245             


Gly Gly  Gly Ala Gly Ala Thr  Cys Thr Cys Cys Thr  Gly Thr Thr 
    1250                 1255                 1260             


Gly Ala  Cys Ala Gly Cys Thr  Thr Gly Ala Gly Cys  Ala Gly Cys 
    1265                 1270                 1275             


Thr Gly  Thr Ala Gly Cys Ala  Gly Thr Thr Cys Gly  Thr Ala Cys 
    1280                 1285                 1290             


Gly Ala  Cys Gly Gly Gly Ala  Gly Cys Gly Ala Cys  Cys Gly Ala 
    1295                 1300                 1305             


Gly Ala  Gly Gly Ala Thr Cys  Ala Cys Cys Gly Gly  Ala Ala Cys 
    1310                 1315                 1320             


Gly Ala  Ala Thr Thr Cys Cys  Ala Cys Thr Cys Cys  Cys Cys Cys 
    1325                 1330                 1335             


Ala Thr  Thr Gly Gly Ala Cys  Thr Cys Ala Cys Cys  Ala Gly Ala 
    1340                 1345                 1350             


Cys Cys  Thr Thr Cys Gly Cys  Cys Gly Gly Ala Cys  Gly Ala Ala 
    1355                 1360                 1365             


Ala Gly  Gly Gly Ala Ala Ala  Gly Thr Cys Cys Cys  Thr Cys Ala 
    1370                 1375                 1380             


Gly Thr  Cys Ala Ala Gly Cys  Gly Cys Ala Thr Gly  Cys Gly Ala 
    1385                 1390                 1395             


Cys Thr  Thr Thr Cys Thr Gly  Ala Ala Gly Gly Ala  Thr Gly Gly 
    1400                 1405                 1410             


Gly Cys  Ala Ala Cys Ala Thr  Gly Ala 
    1415                 1420         


<210>  14
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Asp Ala Asp Glu Ala Leu Ala Gly Ala His Leu Trp Ser Leu 
1               5                   10                  15      


Thr Gln Lys Thr Cys Leu Arg Phe Glu Pro Arg Ala Arg Ser Gly Pro 
            20                  25                  30          


Pro Ala Ser Pro Pro Gly Arg Pro Arg Ser Arg Leu His Pro Ala Gly 
        35                  40                  45              


Met Glu Gly Ile Lys Val Phe Leu His Glu Arg Glu Leu Trp Leu Lys 
    50                  55                  60                  


Phe His Glu Val Thr Glu Met Ile Ile Thr Lys Ala Gly Arg Arg Met 
65                  70                  75                  80  


Phe Pro Ser Tyr Lys Val Lys Val Thr Gly Ile Asn Pro Lys Thr Lys 
                85                  90                  95      


Tyr Ile Leu Leu Met Asp Ile Val Pro Ala Asp Asp His Arg Tyr Lys 
            100                 105                 110         


Phe Ala Asp Asn Lys Trp Cys Val Thr Gly Lys Ala Glu Pro Ala Met 
        115                 120                 125             


Ala Gly Arg Leu Tyr Val His Pro Asp Ser Pro Ala Thr Gly Ala His 
    130                 135                 140                 


Trp Met Arg Gln Leu Val Ser Phe Gln Lys Leu Lys Leu Thr Asn Asn 
145                 150                 155                 160 


His Leu Asp Pro Phe Gly His Ile Ile Leu Asn Ser Met His Lys Tyr 
                165                 170                 175     


Gln Pro Arg Leu His Ile Val Lys Ala Asp Glu Asn Asn Gly Phe Gly 
            180                 185                 190         


Ser Lys Asn Thr Ala Phe Cys Thr His Val Phe Pro Glu Thr Ala Phe 
        195                 200                 205             


Ile Ala Val Thr Ser Tyr Gln Asn His Lys Ile Thr Gln Leu Lys Ile 
    210                 215                 220                 


Glu Asn Asn Pro Phe Ala Lys Gly Phe Arg Gly Ser Asp Asp Met Glu 
225                 230                 235                 240 


Leu His Arg Met Ser Arg Met Gln Ser Lys Glu Tyr Pro Val Val Pro 
                245                 250                 255     


Arg Ser Thr Val Arg Gln Lys Val Ala Ser Asn His Ser Pro Phe Ser 
            260                 265                 270         


Ser Glu Ser Arg Ala Leu Ser Thr Ser Ser Asn Leu Gly Ser Gln Tyr 
        275                 280                 285             


Gln Cys Glu Asn Gly Val Ser Gly Pro Ser Gln Asp Leu Leu Pro Pro 
    290                 295                 300                 


Pro Asn Pro Tyr Pro Leu Pro Gln Glu His Ser Gln Ile Tyr His Cys 
305                 310                 315                 320 


Thr Lys Arg Lys Glu Glu Glu Cys Ser Thr Thr Asp His Pro Tyr Lys 
                325                 330                 335     


Lys Pro Tyr Met Glu Thr Ser Pro Ser Glu Glu Asp Ser Phe Tyr Arg 
            340                 345                 350         


Ser Ser Tyr Pro Gln Gln Gln Gly Leu Gly Ala Ser Tyr Arg Thr Glu 
        355                 360                 365             


Ser Ala Gln Arg Gln Ala Cys Met Tyr Ala Ser Ser Ala Pro Pro Ser 
    370                 375                 380                 


Glu Pro Val Pro Ser Leu Glu Asp Ile Ser Cys Asn Thr Trp Pro Ser 
385                 390                 395                 400 


Met Pro Ser Tyr Ser Ser Cys Thr Val Thr Thr Val Gln Pro Trp Thr 
                405                 410                 415     


Gly Tyr Pro Thr Ser Thr Ser Pro Leu Thr Ser Pro Arg Gly Pro Trp 
            420                 425                 430         


Ser Leu Gly Trp Leu Ala Trp Gln Pro Trp Leu Pro Thr Ala Gly Arg 
        435                 440                 445             


Gly Asn Val Pro Ser Thr Arg Pro Pro Val Ala His Gln Pro Val Val 
    450                 455                 460                 


Ser Ser Val Gly Pro Gln Thr Gly Leu Gln Ser Pro Gly Thr Leu Gln 
465                 470                 475                 480 


Pro Pro Glu Phe Leu Tyr Ser His Gly Val Gln Gly Leu Tyr Pro Leu 
                485                 490                 495     


Ile Ser Thr Thr Leu Cys Thr Glu Leu Ala Trp Cys Arg Val Glu Arg 
            500                 505                 510         


Gln 
    


<210>  15
<211>  1542
<212>  PRT
<213>  Homo sapiens

<400>  15

Ala Thr Gly Gly Cys Cys Gly Ala Cys Gly Cys Ala Gly Ala Cys Gly 
1               5                   10                  15      


Ala Gly Gly Cys Thr Thr Thr Gly Gly Cys Thr Gly Gly Cys Gly Cys 
            20                  25                  30          


Ala Cys Ala Cys Cys Thr Cys Thr Gly Gly Ala Gly Cys Cys Thr Gly 
        35                  40                  45              


Ala Cys Gly Cys Ala Ala Ala Ala Gly Ala Cys Cys Thr Gly Cys Cys 
    50                  55                  60                  


Thr Gly Cys Gly Ala Thr Thr Cys Gly Ala Ala Cys Cys Gly Ala Gly 
65                  70                  75                  80  


Ala Gly Cys Gly Cys Gly Cys Thr Cys Gly Gly Gly Gly Cys Cys Cys 
                85                  90                  95      


Cys Cys Ala Gly Cys Ala Ala Gly Thr Cys Cys Cys Cys Cys Cys Gly 
            100                 105                 110         


Gly Thr Cys Gly Thr Cys Cys Cys Cys Gly Cys Ala Gly Cys Cys Gly 
        115                 120                 125             


Cys Cys Thr Thr Cys Ala Cys Cys Cys Ala Gly Cys Ala Gly Gly Cys 
    130                 135                 140                 


Ala Thr Gly Gly Ala Gly Gly Gly Ala Ala Thr Cys Ala Ala Ala Gly 
145                 150                 155                 160 


Thr Gly Thr Thr Thr Cys Thr Cys Cys Ala Thr Gly Ala Ala Ala Gly 
                165                 170                 175     


Ala Gly Ala Ala Cys Thr Gly Thr Gly Gly Cys Thr Ala Ala Ala Ala 
            180                 185                 190         


Thr Thr Cys Cys Ala Cys Gly Ala Ala Gly Thr Cys Ala Cys Gly Gly 
        195                 200                 205             


Ala Ala Ala Thr Gly Ala Thr Cys Ala Thr Ala Ala Cys Cys Ala Ala 
    210                 215                 220                 


Gly Gly Cys Thr Gly Gly Ala Ala Gly Gly Cys Gly Gly Ala Thr Gly 
225                 230                 235                 240 


Thr Thr Thr Cys Cys Cys Ala Gly Thr Thr Ala Cys Ala Ala Ala Gly 
                245                 250                 255     


Thr Gly Ala Ala Gly Gly Thr Gly Ala Cys Gly Gly Gly Cys Ala Thr 
            260                 265                 270         


Thr Ala Ala Thr Cys Cys Cys Ala Ala Ala Ala Cys Gly Ala Ala Gly 
        275                 280                 285             


Thr Ala Cys Ala Thr Thr Cys Thr Thr Cys Thr Cys Ala Thr Gly Gly 
    290                 295                 300                 


Ala Cys Ala Thr Thr Gly Thr Ala Cys Cys Thr Gly Cys Gly Gly Ala 
305                 310                 315                 320 


Cys Gly Ala Thr Cys Ala Cys Ala Gly Ala Thr Ala Cys Ala Ala Ala 
                325                 330                 335     


Thr Thr Cys Gly Cys Ala Gly Ala Thr Ala Ala Thr Ala Ala Ala Thr 
            340                 345                 350         


Gly Gly Thr Gly Thr Gly Thr Gly Ala Cys Gly Gly Gly Cys Ala Ala 
        355                 360                 365             


Ala Gly Cys Thr Gly Ala Gly Cys Cys Cys Gly Cys Cys Ala Thr Gly 
    370                 375                 380                 


Gly Cys Thr Gly Gly Cys Cys Gly Cys Cys Thr Gly Thr Ala Cys Gly 
385                 390                 395                 400 


Thr Gly Cys Ala Cys Cys Cys Ala Gly Ala Cys Thr Cys Cys Cys Cys 
                405                 410                 415     


Cys Gly Cys Cys Ala Cys Cys Gly Gly Gly Gly Cys Gly Cys Ala Thr 
            420                 425                 430         


Thr Gly Gly Ala Thr Gly Ala Gly Gly Cys Ala Gly Cys Thr Cys Gly 
        435                 440                 445             


Thr Cys Thr Cys Cys Thr Thr Cys Cys Ala Gly Ala Ala Ala Cys Thr 
    450                 455                 460                 


Cys Ala Ala Gly Cys Thr Cys Ala Cys Cys Ala Ala Cys Ala Ala Cys 
465                 470                 475                 480 


Cys Ala Cys Cys Thr Gly Gly Ala Cys Cys Cys Ala Thr Thr Thr Gly 
                485                 490                 495     


Gly Gly Cys Ala Thr Ala Thr Thr Ala Thr Thr Cys Thr Ala Ala Ala 
            500                 505                 510         


Thr Thr Cys Cys Ala Thr Gly Cys Ala Cys Ala Ala Ala Thr Ala Cys 
        515                 520                 525             


Cys Ala Gly Cys Cys Thr Ala Gly Ala Thr Thr Ala Cys Ala Cys Ala 
    530                 535                 540                 


Thr Cys Gly Thr Gly Ala Ala Ala Gly Cys Gly Gly Ala Thr Gly Ala 
545                 550                 555                 560 


Ala Ala Ala Thr Ala Ala Thr Gly Gly Ala Thr Thr Thr Gly Gly Cys 
                565                 570                 575     


Thr Cys Ala Ala Ala Ala Ala Ala Thr Ala Cys Ala Gly Cys Gly Thr 
            580                 585                 590         


Thr Cys Thr Gly Cys Ala Cys Thr Cys Ala Cys Gly Thr Cys Thr Thr 
        595                 600                 605             


Thr Cys Cys Thr Gly Ala Gly Ala Cys Thr Gly Cys Gly Thr Thr Thr 
    610                 615                 620                 


Ala Thr Ala Gly Cys Ala Gly Thr Gly Ala Cys Thr Thr Cys Cys Thr 
625                 630                 635                 640 


Ala Cys Cys Ala Gly Ala Ala Cys Cys Ala Cys Ala Ala Gly Ala Thr 
                645                 650                 655     


Cys Ala Cys Gly Cys Ala Ala Thr Thr Ala Ala Ala Gly Ala Thr Thr 
            660                 665                 670         


Gly Ala Gly Ala Ala Thr Ala Ala Thr Cys Cys Cys Thr Thr Thr Gly 
        675                 680                 685             


Cys Cys Ala Ala Ala Gly Gly Ala Thr Thr Thr Cys Gly Gly Gly Gly 
    690                 695                 700                 


Cys Ala Gly Thr Gly Ala Thr Gly Ala Cys Ala Thr Gly Gly Ala Gly 
705                 710                 715                 720 


Cys Thr Gly Cys Ala Cys Ala Gly Ala Ala Thr Gly Thr Cys Ala Ala 
                725                 730                 735     


Gly Ala Ala Thr Gly Cys Ala Ala Ala Gly Thr Ala Ala Ala Gly Ala 
            740                 745                 750         


Ala Thr Ala Thr Cys Cys Cys Gly Thr Gly Gly Thr Cys Cys Cys Cys 
        755                 760                 765             


Ala Gly Gly Ala Gly Cys Ala Cys Cys Gly Thr Gly Ala Gly Gly Cys 
    770                 775                 780                 


Ala Ala Ala Ala Ala Gly Thr Gly Gly Cys Cys Thr Cys Cys Ala Ala 
785                 790                 795                 800 


Cys Cys Ala Cys Ala Gly Thr Cys Cys Thr Thr Thr Cys Ala Gly Cys 
                805                 810                 815     


Ala Gly Cys Gly Ala Gly Thr Cys Thr Cys Gly Ala Gly Cys Thr Cys 
            820                 825                 830         


Thr Cys Thr Cys Cys Ala Cys Cys Thr Cys Ala Thr Cys Cys Ala Ala 
        835                 840                 845             


Thr Thr Thr Gly Gly Gly Gly Thr Cys Cys Cys Ala Ala Thr Ala Cys 
    850                 855                 860                 


Cys Ala Gly Thr Gly Thr Gly Ala Gly Ala Ala Thr Gly Gly Thr Gly 
865                 870                 875                 880 


Thr Thr Thr Cys Cys Gly Gly Cys Cys Cys Cys Thr Cys Cys Cys Ala 
                885                 890                 895     


Gly Gly Ala Cys Cys Thr Cys Cys Thr Gly Cys Cys Thr Cys Cys Ala 
            900                 905                 910         


Cys Cys Cys Ala Ala Cys Cys Cys Ala Thr Ala Cys Cys Cys Ala Cys 
        915                 920                 925             


Thr Gly Cys Cys Cys Cys Ala Gly Gly Ala Gly Cys Ala Thr Ala Gly 
    930                 935                 940                 


Cys Cys Ala Ala Ala Thr Thr Thr Ala Cys Cys Ala Thr Thr Gly Thr 
945                 950                 955                 960 


Ala Cys Cys Ala Ala Gly Ala Gly Gly Ala Ala Ala Gly Ala Gly Gly 
                965                 970                 975     


Ala Ala Gly Ala Ala Thr Gly Thr Thr Cys Cys Ala Cys Cys Ala Cys 
            980                 985                 990         


Ala Gly Ala Cys Cys Ala Thr Cys  Cys Cys Thr Ala Thr  Ala Ala Gly 
        995                 1000                 1005             


Ala Ala  Gly Cys Cys Cys Thr  Ala Cys Ala Thr Gly  Gly Ala Gly 
    1010                 1015                 1020             


Ala Cys  Ala Thr Cys Ala Cys  Cys Cys Ala Gly Thr  Gly Ala Ala 
    1025                 1030                 1035             


Gly Ala  Ala Gly Ala Thr Thr  Cys Cys Thr Thr Cys  Thr Ala Cys 
    1040                 1045                 1050             


Cys Gly  Cys Thr Cys Thr Ala  Gly Cys Thr Ala Thr  Cys Cys Ala 
    1055                 1060                 1065             


Cys Ala  Gly Cys Ala Gly Cys  Ala Gly Gly Gly Cys  Cys Thr Gly 
    1070                 1075                 1080             


Gly Gly  Thr Gly Cys Cys Thr  Cys Cys Thr Ala Cys  Ala Gly Gly 
    1085                 1090                 1095             


Ala Cys  Ala Gly Ala Gly Thr  Cys Gly Gly Cys Ala  Cys Ala Gly 
    1100                 1105                 1110             


Cys Gly  Gly Cys Ala Ala Gly  Cys Thr Thr Gly Cys  Ala Thr Gly 
    1115                 1120                 1125             


Thr Ala  Thr Gly Cys Cys Ala  Gly Cys Thr Cys Thr  Gly Cys Gly 
    1130                 1135                 1140             


Cys Cys  Cys Cys Cys Cys Ala  Gly Cys Gly Ala Gly  Cys Cys Thr 
    1145                 1150                 1155             


Gly Thr  Gly Cys Cys Cys Ala  Gly Cys Cys Thr Ala  Gly Ala Gly 
    1160                 1165                 1170             


Gly Ala  Cys Ala Thr Cys Ala  Gly Cys Thr Gly Cys  Ala Ala Cys 
    1175                 1180                 1185             


Ala Cys  Gly Thr Gly Gly Cys  Cys Ala Ala Gly Cys  Ala Thr Gly 
    1190                 1195                 1200             


Cys Cys  Thr Thr Cys Cys Thr  Ala Cys Ala Gly Cys  Ala Gly Cys 
    1205                 1210                 1215             


Thr Gly  Cys Ala Cys Cys Gly  Thr Cys Ala Cys Cys  Ala Cys Cys 
    1220                 1225                 1230             


Gly Thr  Gly Cys Ala Gly Cys  Cys Ala Thr Gly Gly  Ala Cys Ala 
    1235                 1240                 1245             


Gly Gly  Cys Thr Ala Cys Cys  Cys Thr Ala Cys Cys  Ala Gly Cys 
    1250                 1255                 1260             


Ala Cys  Thr Thr Cys Thr Cys  Cys Gly Cys Thr Cys  Ala Cys Thr 
    1265                 1270                 1275             


Thr Cys  Ala Cys Cys Thr Cys  Gly Gly Gly Gly Cys  Cys Cys Cys 
    1280                 1285                 1290             


Thr Gly  Gly Thr Cys Cys Cys  Thr Cys Gly Gly Cys  Thr Gly Gly 
    1295                 1300                 1305             


Cys Thr  Gly Gly Cys Ala Thr  Gly Gly Cys Ala Ala  Cys Cys Ala 
    1310                 1315                 1320             


Thr Gly  Gly Cys Thr Cys Cys  Cys Cys Ala Cys Ala  Gly Cys Thr 
    1325                 1330                 1335             


Gly Gly  Gly Ala Gly Ala Gly  Gly Gly Ala Ala Thr  Gly Thr Thr 
    1340                 1345                 1350             


Cys Cys  Cys Ala Gly Cys Ala  Cys Cys Ala Gly Ala  Cys Cys Thr 
    1355                 1360                 1365             


Cys Cys  Cys Gly Thr Gly Gly  Cys Cys Cys Ala Cys  Cys Ala Gly 
    1370                 1375                 1380             


Cys Cys  Thr Gly Thr Gly Gly  Thr Cys Ala Gly Cys  Ala Gly Thr 
    1385                 1390                 1395             


Gly Thr  Gly Gly Gly Gly Cys  Cys Cys Cys Ala Ala  Ala Cys Thr 
    1400                 1405                 1410             


Gly Gly  Cys Cys Thr Gly Cys  Ala Gly Thr Cys Cys  Cys Cys Thr 
    1415                 1420                 1425             


Gly Gly  Cys Ala Cys Cys Cys  Thr Thr Cys Ala Gly  Cys Cys Cys 
    1430                 1435                 1440             


Cys Cys  Thr Gly Ala Gly Thr  Thr Cys Cys Thr Cys  Thr Ala Cys 
    1445                 1450                 1455             


Thr Cys  Thr Cys Ala Thr Gly  Gly Cys Gly Thr Gly  Cys Ala Ala 
    1460                 1465                 1470             


Gly Gly  Ala Cys Thr Cys Thr  Ala Thr Cys Cys Cys  Cys Thr Cys 
    1475                 1480                 1485             


Ala Thr  Cys Ala Gly Thr Ala  Cys Cys Ala Cys Thr  Cys Thr Gly 
    1490                 1495                 1500             


Thr Gly  Cys Ala Cys Gly Gly  Ala Gly Thr Thr Gly  Gly Cys Ala 
    1505                 1510                 1515             


Thr Gly  Gly Thr Gly Cys Ala  Gly Ala Gly Thr Gly  Gly Ala Gly 
    1520                 1525                 1530             


Cys Gly  Ala Cys Ala Ala Thr  Ala Gly 
    1535                 1540         


<210>  16
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Asp Ala Asp Glu Gly Phe Gly Leu Ala His Thr Pro Leu Glu 
1               5                   10                  15      


Pro Asp Ala Lys Asp Leu Pro Cys Asp Ser Lys Pro Glu Ser Ala Leu 
            20                  25                  30          


Gly Ala Pro Ser Lys Ser Pro Ser Ser Pro Gln Ala Ala Phe Thr Gln 
        35                  40                  45              


Gln Gly Met Glu Gly Ile Lys Val Phe Leu His Glu Arg Glu Leu Trp 
    50                  55                  60                  


Leu Lys Phe His Glu Val Gly Thr Glu Met Ile Ile Thr Lys Ala Gly 
65                  70                  75                  80  


Arg Arg Met Phe Pro Ser Tyr Lys Val Lys Val Thr Gly Leu Asn Pro 
                85                  90                  95      


Lys Thr Lys Tyr Ile Leu Leu Met Asp Ile Val Pro Ala Asp Asp His 
            100                 105                 110         


Arg Tyr Lys Phe Ala Asp Asn Lys Trp Ser Val Thr Gly Lys Ala Glu 
        115                 120                 125             


Pro Ala Met Pro Gly Arg Leu Tyr Val His Pro Asp Ser Pro Ala Thr 
    130                 135                 140                 


Gly Ala His Trp Met Arg Gln Leu Val Ser Phe Gln Lys Leu Lys Leu 
145                 150                 155                 160 


Thr Asn Asn His Leu Asp Pro Phe Gly His Ile Ile Leu Asn Ser Met 
                165                 170                 175     


His Lys Tyr Gln Pro Arg Leu His Ile Val Lys Ala Asp Glu Asn Asn 
            180                 185                 190         


Gly Phe Gly Ser Lys Asn Thr Ala Phe Cys Thr His Val Phe Pro Glu 
        195                 200                 205             


Thr Ala Phe Ile Ala Val Thr Ser Tyr Gln Asn His Lys Ile Thr Gln 
    210                 215                 220                 


Leu Lys Ile Glu Asn Asn Pro Phe Ala Lys Gly Phe Arg Gly Ser Asp 
225                 230                 235                 240 


Asp Met Glu Leu His Arg Met Ser Arg Met Gln Ser Lys Glu Tyr Pro 
                245                 250                 255     


Val Val Pro Arg Ser Thr Val Arg Gln Lys Val Ala Ser Asn His Ser 
            260                 265                 270         


Pro Phe Ser Ser Glu Ser Arg Ala Leu Ser Thr Ser Ser Asn Leu Gly 
        275                 280                 285             


Ser Gln Tyr Gln Cys Glu Asn Gly Val Ser Gly Pro Ser Gln Asp Leu 
    290                 295                 300                 


Leu Pro Pro Pro Asn Pro Tyr Pro Leu Pro Gln Glu His Ser Gln Ile 
305                 310                 315                 320 


Tyr His Cys Thr Lys Arg Lys Glu Glu Glu Cys Ser Thr Thr Asp His 
                325                 330                 335     


Pro Tyr Lys Lys Pro Tyr Met Glu Thr Ser Pro Ser Glu Glu Asp Ser 
            340                 345                 350         


Phe Tyr Arg Ser Ser Tyr Pro Gln Gln Gln Gly Leu Gly Ala Ser Tyr 
        355                 360                 365             


Arg Thr Glu Ser Ala Gln Arg Gln Ala Cys Met Tyr Ala Ser Ser Ala 
    370                 375                 380                 


Pro Pro Ser Glu Pro Val Pro Ser Leu Glu Asp Ile Ser Cys Asn Thr 
385                 390                 395                 400 


Trp Pro Ser Met Pro Ser Tyr Ser Ser Cys Thr Val Thr Thr Val Gln 
                405                 410                 415     


Pro Met Asp Arg Leu Pro Tyr Gln His Phe Ser Ala His Phe Thr Ser 
            420                 425                 430         


Gly Pro Leu Val Pro Arg Leu Ala Gly Met Ala Asn His Gly Ser Pro 
        435                 440                 445             


Gln Leu Gly Glu Gly Met Phe Gln His Gln Thr Ser Val Ala His Gln 
    450                 455                 460                 


Pro Val Val Arg Gln Cys Gly Pro Gln Thr Gly Leu Gln Ser Pro Gly 
465                 470                 475                 480 


Thr Leu Gln Pro Pro Glu Phe Leu Tyr Ser His Gly Val Pro Arg Thr 
                485                 490                 495     


Leu Ser Pro His Gln Tyr His Ser Val His Gly Val Gly Met Val Pro 
            500                 505                 510         


Glu Trp Ser Asp Asn Ser 
        515             


<210>  17
<211>  1557
<212>  PRT
<213>  Homo sapiens

<400>  17

Ala Thr Gly Gly Cys Cys Gly Ala Cys Gly Cys Ala Gly Ala Cys Gly 
1               5                   10                  15      


Ala Gly Gly Gly Cys Thr Thr Thr Gly Gly Cys Cys Thr Gly Gly Cys 
            20                  25                  30          


Gly Cys Ala Cys Ala Cys Gly Cys Cys Thr Cys Thr Gly Gly Ala Gly 
        35                  40                  45              


Cys Cys Thr Gly Ala Cys Gly Cys Ala Ala Ala Ala Gly Ala Cys Cys 
    50                  55                  60                  


Thr Gly Cys Cys Cys Thr Gly Cys Gly Ala Thr Thr Cys Gly Ala Ala 
65                  70                  75                  80  


Ala Cys Cys Cys Gly Ala Gly Ala Gly Cys Gly Cys Gly Cys Thr Cys 
                85                  90                  95      


Gly Gly Gly Gly Cys Cys Cys Cys Cys Ala Gly Cys Ala Ala Gly Thr 
            100                 105                 110         


Cys Cys Cys Cys Gly Thr Cys Gly Thr Cys Cys Cys Cys Gly Cys Ala 
        115                 120                 125             


Gly Gly Cys Cys Gly Cys Cys Thr Thr Cys Ala Cys Cys Cys Ala Gly 
    130                 135                 140                 


Cys Ala Gly Gly Gly Cys Ala Thr Gly Gly Ala Gly Gly Gly Ala Ala 
145                 150                 155                 160 


Thr Cys Ala Ala Ala Gly Thr Gly Thr Thr Thr Cys Thr Cys Cys Ala 
                165                 170                 175     


Thr Gly Ala Ala Ala Gly Ala Gly Ala Ala Cys Thr Gly Thr Gly Gly 
            180                 185                 190         


Cys Thr Ala Ala Ala Ala Thr Thr Cys Cys Ala Cys Gly Ala Ala Gly 
        195                 200                 205             


Thr Gly Gly Gly Cys Ala Cys Gly Gly Ala Ala Ala Thr Gly Ala Thr 
    210                 215                 220                 


Cys Ala Thr Ala Ala Cys Cys Ala Ala Gly Gly Cys Thr Gly Gly Ala 
225                 230                 235                 240 


Ala Gly Gly Cys Gly Gly Ala Thr Gly Thr Thr Thr Cys Cys Cys Ala 
                245                 250                 255     


Gly Thr Thr Ala Cys Ala Ala Ala Gly Thr Gly Ala Ala Gly Gly Thr 
            260                 265                 270         


Gly Ala Cys Gly Gly Gly Cys Cys Thr Thr Ala Ala Thr Cys Cys Cys 
        275                 280                 285             


Ala Ala Ala Ala Cys Gly Ala Ala Gly Thr Ala Cys Ala Thr Thr Cys 
    290                 295                 300                 


Thr Thr Cys Thr Cys Ala Thr Gly Gly Ala Cys Ala Thr Thr Gly Thr 
305                 310                 315                 320 


Ala Cys Cys Thr Gly Cys Cys Gly Ala Cys Gly Ala Thr Cys Ala Cys 
                325                 330                 335     


Ala Gly Ala Thr Ala Cys Ala Ala Ala Thr Thr Cys Gly Cys Ala Gly 
            340                 345                 350         


Ala Thr Ala Ala Thr Ala Ala Ala Thr Gly Gly Thr Cys Thr Gly Thr 
        355                 360                 365             


Gly Ala Cys Gly Gly Gly Cys Ala Ala Ala Gly Cys Thr Gly Ala Gly 
    370                 375                 380                 


Cys Cys Cys Gly Cys Cys Ala Thr Gly Cys Cys Thr Gly Gly Cys Cys 
385                 390                 395                 400 


Gly Cys Cys Thr Gly Thr Ala Cys Gly Thr Gly Cys Ala Cys Cys Cys 
                405                 410                 415     


Ala Gly Ala Cys Thr Cys Cys Cys Cys Cys Gly Cys Cys Ala Cys Cys 
            420                 425                 430         


Gly Gly Gly Gly Cys Gly Cys Ala Thr Thr Gly Gly Ala Thr Gly Ala 
        435                 440                 445             


Gly Gly Cys Ala Gly Cys Thr Cys Gly Thr Cys Thr Cys Cys Thr Thr 
    450                 455                 460                 


Cys Cys Ala Gly Ala Ala Ala Cys Thr Cys Ala Ala Gly Cys Thr Cys 
465                 470                 475                 480 


Ala Cys Cys Ala Ala Cys Ala Ala Cys Cys Ala Cys Cys Thr Gly Gly 
                485                 490                 495     


Ala Cys Cys Cys Ala Thr Thr Thr Gly Gly Gly Cys Ala Thr Ala Thr 
            500                 505                 510         


Thr Ala Thr Thr Cys Thr Ala Ala Ala Thr Thr Cys Cys Ala Thr Gly 
        515                 520                 525             


Cys Ala Cys Ala Ala Ala Thr Ala Cys Cys Ala Gly Cys Cys Thr Ala 
    530                 535                 540                 


Gly Ala Thr Thr Ala Cys Ala Cys Ala Thr Cys Gly Thr Gly Ala Ala 
545                 550                 555                 560 


Ala Gly Cys Gly Gly Ala Thr Gly Ala Ala Ala Ala Thr Ala Ala Thr 
                565                 570                 575     


Gly Gly Ala Thr Thr Thr Gly Gly Cys Thr Cys Ala Ala Ala Ala Ala 
            580                 585                 590         


Ala Thr Ala Cys Ala Gly Cys Gly Thr Thr Cys Thr Gly Cys Ala Cys 
        595                 600                 605             


Thr Cys Ala Cys Gly Thr Cys Thr Thr Thr Cys Cys Thr Gly Ala Gly 
    610                 615                 620                 


Ala Cys Thr Gly Cys Gly Thr Thr Thr Ala Thr Ala Gly Cys Ala Gly 
625                 630                 635                 640 


Thr Gly Ala Cys Thr Thr Cys Cys Thr Ala Cys Cys Ala Gly Ala Ala 
                645                 650                 655     


Cys Cys Ala Cys Ala Ala Gly Ala Thr Cys Ala Cys Gly Cys Ala Ala 
            660                 665                 670         


Thr Thr Ala Ala Ala Gly Ala Thr Thr Gly Ala Gly Ala Ala Thr Ala 
        675                 680                 685             


Ala Thr Cys Cys Cys Thr Thr Thr Gly Cys Cys Ala Ala Ala Gly Gly 
    690                 695                 700                 


Ala Thr Thr Thr Cys Gly Gly Gly Gly Cys Ala Gly Thr Gly Ala Thr 
705                 710                 715                 720 


Gly Ala Cys Ala Thr Gly Gly Ala Gly Cys Thr Gly Cys Ala Cys Ala 
                725                 730                 735     


Gly Ala Ala Thr Gly Thr Cys Ala Ala Gly Ala Ala Thr Gly Cys Ala 
            740                 745                 750         


Ala Ala Gly Thr Ala Ala Ala Gly Ala Ala Thr Ala Thr Cys Cys Cys 
        755                 760                 765             


Gly Thr Gly Gly Thr Cys Cys Cys Cys Ala Gly Gly Ala Gly Cys Ala 
    770                 775                 780                 


Cys Cys Gly Thr Gly Ala Gly Gly Cys Ala Ala Ala Ala Ala Gly Thr 
785                 790                 795                 800 


Gly Gly Cys Cys Thr Cys Cys Ala Ala Cys Cys Ala Cys Ala Gly Thr 
                805                 810                 815     


Cys Cys Thr Thr Thr Cys Ala Gly Cys Ala Gly Cys Gly Ala Gly Thr 
            820                 825                 830         


Cys Thr Cys Gly Ala Gly Cys Thr Cys Thr Cys Thr Cys Cys Ala Cys 
        835                 840                 845             


Cys Thr Cys Ala Thr Cys Cys Ala Ala Thr Thr Thr Gly Gly Gly Gly 
    850                 855                 860                 


Thr Cys Cys Cys Ala Ala Thr Ala Cys Cys Ala Gly Thr Gly Thr Gly 
865                 870                 875                 880 


Ala Gly Ala Ala Thr Gly Gly Thr Gly Thr Thr Thr Cys Cys Gly Gly 
                885                 890                 895     


Cys Cys Cys Cys Thr Cys Cys Cys Ala Gly Gly Ala Cys Cys Thr Cys 
            900                 905                 910         


Cys Thr Gly Cys Cys Thr Cys Cys Ala Cys Cys Cys Ala Ala Cys Cys 
        915                 920                 925             


Cys Ala Thr Ala Cys Cys Cys Ala Cys Thr Gly Cys Cys Cys Cys Ala 
    930                 935                 940                 


Gly Gly Ala Gly Cys Ala Thr Ala Gly Cys Cys Ala Ala Ala Thr Thr 
945                 950                 955                 960 


Thr Ala Cys Cys Ala Thr Thr Gly Thr Ala Cys Cys Ala Ala Gly Ala 
                965                 970                 975     


Gly Gly Ala Ala Ala Gly Ala Gly Gly Ala Ala Gly Ala Ala Thr Gly 
            980                 985                 990         


Thr Thr Cys Cys Ala Cys Cys Ala  Cys Ala Gly Ala Cys  Cys Ala Thr 
        995                 1000                 1005             


Cys Cys  Cys Thr Ala Thr Ala  Ala Gly Ala Ala Gly  Cys Cys Cys 
    1010                 1015                 1020             


Thr Ala  Cys Ala Thr Gly Gly  Ala Gly Ala Cys Ala  Thr Cys Ala 
    1025                 1030                 1035             


Cys Cys  Cys Ala Gly Thr Gly  Ala Ala Gly Ala Ala  Gly Ala Thr 
    1040                 1045                 1050             


Thr Cys  Cys Thr Thr Cys Thr  Ala Cys Cys Gly Cys  Thr Cys Thr 
    1055                 1060                 1065             


Ala Gly  Cys Thr Ala Thr Cys  Cys Ala Cys Ala Gly  Cys Ala Gly 
    1070                 1075                 1080             


Cys Ala  Gly Gly Gly Cys Cys  Thr Gly Gly Gly Thr  Gly Cys Cys 
    1085                 1090                 1095             


Thr Cys  Cys Thr Ala Cys Ala  Gly Gly Ala Cys Ala  Gly Ala Gly 
    1100                 1105                 1110             


Thr Cys  Gly Gly Cys Ala Cys  Ala Gly Cys Gly Gly  Cys Ala Ala 
    1115                 1120                 1125             


Gly Cys  Thr Thr Gly Cys Ala  Thr Gly Thr Ala Thr  Gly Cys Cys 
    1130                 1135                 1140             


Ala Gly  Cys Thr Cys Thr Gly  Cys Gly Cys Cys Cys  Cys Cys Cys 
    1145                 1150                 1155             


Ala Gly  Cys Gly Ala Gly Cys  Cys Thr Gly Thr Gly  Cys Cys Cys 
    1160                 1165                 1170             


Ala Gly  Cys Cys Thr Ala Gly  Ala Gly Gly Ala Cys  Ala Thr Cys 
    1175                 1180                 1185             


Ala Gly  Cys Thr Gly Cys Ala  Ala Cys Ala Cys Gly  Thr Gly Gly 
    1190                 1195                 1200             


Cys Cys  Ala Ala Gly Cys Ala  Thr Gly Cys Cys Thr  Thr Cys Cys 
    1205                 1210                 1215             


Thr Ala  Cys Ala Gly Cys Ala  Gly Cys Thr Gly Cys  Ala Cys Cys 
    1220                 1225                 1230             


Gly Thr  Cys Ala Cys Cys Ala  Cys Cys Gly Thr Gly  Cys Ala Gly 
    1235                 1240                 1245             


Cys Cys  Cys Ala Thr Gly Gly  Ala Cys Ala Gly Gly  Cys Thr Ala 
    1250                 1255                 1260             


Cys Cys  Cys Thr Ala Cys Cys  Ala Gly Cys Ala Cys  Thr Thr Cys 
    1265                 1270                 1275             


Thr Cys  Cys Gly Cys Thr Cys  Ala Cys Thr Thr Cys  Ala Cys Cys 
    1280                 1285                 1290             


Thr Cys  Gly Gly Gly Gly Cys  Cys Cys Cys Thr Gly  Gly Thr Cys 
    1295                 1300                 1305             


Cys Cys  Thr Cys Gly Gly Cys  Thr Gly Gly Cys Thr  Gly Gly Cys 
    1310                 1315                 1320             


Ala Thr  Gly Gly Cys Cys Ala  Ala Cys Cys Ala Thr  Gly Gly Cys 
    1325                 1330                 1335             


Thr Cys  Cys Cys Cys Ala Cys  Ala Gly Cys Thr Gly  Gly Gly Ala 
    1340                 1345                 1350             


Gly Ala  Gly Gly Gly Ala Ala  Thr Gly Thr Thr Cys  Cys Ala Gly 
    1355                 1360                 1365             


Cys Ala  Cys Cys Ala Gly Ala  Cys Cys Thr Cys Cys  Gly Thr Gly 
    1370                 1375                 1380             


Gly Cys  Cys Cys Ala Cys Cys  Ala Gly Cys Cys Thr  Gly Thr Gly 
    1385                 1390                 1395             


Gly Thr  Cys Ala Gly Gly Cys  Ala Gly Thr Gly Thr  Gly Gly Gly 
    1400                 1405                 1410             


Cys Cys  Thr Cys Ala Gly Ala  Cys Thr Gly Gly Cys  Cys Thr Gly 
    1415                 1420                 1425             


Cys Ala  Gly Thr Cys Cys Cys  Cys Thr Gly Gly Cys  Ala Cys Cys 
    1430                 1435                 1440             


Cys Thr  Thr Cys Ala Gly Cys  Cys Cys Cys Cys Thr  Gly Ala Gly 
    1445                 1450                 1455             


Thr Thr  Cys Cys Thr Cys Thr  Ala Cys Thr Cys Thr  Cys Ala Thr 
    1460                 1465                 1470             


Gly Gly  Cys Gly Thr Gly Cys  Cys Ala Ala Gly Gly  Ala Cys Thr 
    1475                 1480                 1485             


Cys Thr  Ala Thr Cys Cys Cys  Cys Thr Cys Ala Thr  Cys Ala Gly 
    1490                 1495                 1500             


Thr Ala  Cys Cys Ala Cys Thr  Cys Thr Gly Thr Gly  Cys Ala Cys 
    1505                 1510                 1515             


Gly Gly  Ala Gly Thr Thr Gly  Gly Cys Ala Thr Gly  Gly Thr Gly 
    1520                 1525                 1530             


Cys Cys  Ala Gly Ala Gly Thr  Gly Gly Ala Gly Cys  Gly Ala Cys 
    1535                 1540                 1545             


Ala Ala  Thr Ala Gly Cys Thr  Ala Ala 
    1550                 1555         


<210>  18
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Gln Pro Leu Cys Pro Pro Leu Ser Glu Ser Trp Met Leu Ser 
1               5                   10                  15      


Ala Ala Trp Gly Pro Thr Arg Arg Pro Pro Pro Ser Asp Lys Asp Cys 
            20                  25                  30          


Gly Arg Ser Leu Val Ser Ser Pro Asp Ser Trp Gly Ser Thr Pro Ala 
        35                  40                  45              


Asp Ser Pro Val Ala Ser Pro Ala Arg Pro Gly Thr Leu Arg Asp Pro 
    50                  55                  60                  


Arg Ala Pro Ser Val Gly Arg Arg Gly Ala Arg Ser Ser Arg Leu Gly 
65                  70                  75                  80  


Ser Gly Gln Arg Gln Ser Ala Ser Glu Arg Glu Lys Leu Arg Met Arg 
                85                  90                  95      


Thr Leu Ala Arg Ala Leu His Glu Leu Arg Arg Phe Leu Pro Pro Ser 
            100                 105                 110         


Val Ala Pro Ala Gly Gln Ser Leu Thr Lys Ile Glu Thr Leu Arg Leu 
        115                 120                 125             


Ala Ile Arg Tyr Ile Gly His Leu Ser Ala Val Leu Gly Leu Ser Glu 
    130                 135                 140                 


Glu Ser Leu Gln Arg Arg Cys Arg Gln Arg Gly Asp Ala Gly Ser Pro 
145                 150                 155                 160 


Arg Gly Cys Pro Leu Cys Pro Asp Asp Cys Pro Ala Gln Met Gln Thr 
                165                 170                 175     


Arg Thr Gln Ala Glu Gly Gln Gly Gln Gly Arg Gly Leu Gly Leu Val 
            180                 185                 190         


Ser Ala Val Arg Ala Gly Ala Ser Trp Gly Ser Pro Pro Ala Cys Pro 
        195                 200                 205             


Gly Ala Arg Ala Ala Pro Glu Pro Arg Asp Pro Pro Ala Leu Phe Ala 
    210                 215                 220                 


Glu Ala Ala Cys Pro Glu Gly Gln Ala Met Glu Pro Ser Pro Pro Ser 
225                 230                 235                 240 


Pro Leu Leu Pro Gly Asp Val Leu Ala Leu Leu Glu Thr Trp Met Pro 
                245                 250                 255     


Leu Ser Pro Leu Glu Trp Leu Pro Glu Glu Pro Lys 
            260                 265             


<210>  19
<211>  807
<212>  PRT
<213>  Homo sapiens

<400>  19

Ala Thr Gly Gly Cys Cys Cys Ala Gly Cys Cys Cys Cys Thr Gly Thr 
1               5                   10                  15      


Gly Cys Cys Cys Gly Cys Cys Gly Cys Thr Cys Thr Cys Cys Gly Ala 
            20                  25                  30          


Gly Thr Cys Cys Thr Gly Gly Ala Thr Gly Cys Thr Cys Thr Cys Thr 
        35                  40                  45              


Gly Cys Gly Gly Cys Cys Thr Gly Gly Gly Gly Cys Cys Cys Ala Ala 
    50                  55                  60                  


Cys Thr Cys Gly Gly Cys Gly Gly Cys Cys Gly Cys Cys Gly Cys Cys 
65                  70                  75                  80  


Cys Thr Cys Cys Gly Ala Cys Ala Ala Gly Gly Ala Cys Thr Gly Cys 
                85                  90                  95      


Gly Gly Cys Cys Gly Cys Thr Cys Cys Cys Thr Cys Gly Thr Cys Thr 
            100                 105                 110         


Cys Gly Thr Cys Cys Cys Cys Ala Gly Ala Cys Thr Cys Ala Thr Gly 
        115                 120                 125             


Gly Gly Gly Cys Ala Gly Cys Ala Cys Cys Cys Cys Ala Gly Cys Cys 
    130                 135                 140                 


Gly Ala Cys Ala Gly Cys Cys Cys Cys Gly Thr Gly Gly Cys Gly Ala 
145                 150                 155                 160 


Gly Cys Cys Cys Cys Gly Cys Gly Cys Gly Gly Cys Cys Ala Gly Gly 
                165                 170                 175     


Cys Ala Cys Cys Cys Thr Cys Cys Gly Gly Gly Ala Cys Cys Cys Cys 
            180                 185                 190         


Cys Gly Cys Gly Cys Cys Cys Cys Cys Thr Cys Cys Gly Thr Ala Gly 
        195                 200                 205             


Gly Thr Ala Gly Gly Cys Gly Cys Gly Gly Cys Gly Cys Gly Cys Gly 
    210                 215                 220                 


Cys Ala Gly Cys Ala Gly Cys Cys Gly Cys Cys Thr Gly Gly Gly Cys 
225                 230                 235                 240 


Ala Gly Cys Gly Gly Gly Cys Ala Gly Ala Gly Gly Cys Ala Gly Ala 
                245                 250                 255     


Gly Cys Gly Cys Cys Ala Gly Thr Gly Ala Gly Cys Gly Gly Gly Ala 
            260                 265                 270         


Gly Ala Ala Ala Cys Thr Gly Cys Gly Cys Ala Thr Gly Cys Gly Cys 
        275                 280                 285             


Ala Cys Gly Cys Thr Gly Gly Cys Cys Cys Gly Cys Gly Cys Cys Cys 
    290                 295                 300                 


Thr Gly Cys Ala Cys Gly Ala Gly Cys Thr Gly Cys Gly Cys Cys Gly 
305                 310                 315                 320 


Cys Thr Thr Thr Cys Thr Ala Cys Cys Gly Cys Cys Gly Thr Cys Cys 
                325                 330                 335     


Gly Thr Gly Gly Cys Gly Cys Cys Cys Gly Cys Gly Gly Gly Cys Cys 
            340                 345                 350         


Ala Gly Ala Gly Cys Cys Thr Gly Ala Cys Cys Ala Ala Gly Ala Thr 
        355                 360                 365             


Cys Gly Ala Gly Ala Cys Gly Cys Thr Gly Cys Gly Cys Cys Thr Gly 
    370                 375                 380                 


Gly Cys Thr Ala Thr Cys Cys Gly Cys Thr Ala Thr Ala Thr Cys Gly 
385                 390                 395                 400 


Gly Cys Cys Ala Cys Cys Thr Gly Thr Cys Gly Gly Cys Cys Gly Thr 
                405                 410                 415     


Gly Cys Thr Ala Gly Gly Cys Cys Thr Cys Ala Gly Cys Gly Ala Gly 
            420                 425                 430         


Gly Ala Gly Ala Gly Thr Cys Thr Cys Cys Ala Gly Cys Gly Cys Cys 
        435                 440                 445             


Gly Gly Thr Gly Cys Cys Gly Gly Cys Ala Gly Cys Gly Cys Gly Gly 
    450                 455                 460                 


Thr Gly Ala Cys Gly Cys Gly Gly Gly Gly Thr Cys Cys Cys Cys Thr 
465                 470                 475                 480 


Cys Gly Gly Gly Gly Cys Thr Gly Cys Cys Cys Gly Cys Thr Gly Thr 
                485                 490                 495     


Gly Cys Cys Cys Cys Gly Ala Cys Gly Ala Cys Thr Gly Cys Cys Cys 
            500                 505                 510         


Cys Gly Cys Gly Cys Ala Gly Ala Thr Gly Cys Ala Gly Ala Cys Ala 
        515                 520                 525             


Cys Gly Gly Ala Cys Gly Cys Ala Gly Gly Cys Thr Gly Ala Gly Gly 
    530                 535                 540                 


Gly Gly Cys Ala Gly Gly Gly Gly Cys Ala Gly Gly Gly Gly Cys Gly 
545                 550                 555                 560 


Cys Gly Gly Gly Cys Thr Gly Gly Gly Cys Cys Thr Gly Gly Thr Ala 
                565                 570                 575     


Thr Cys Cys Gly Cys Cys Gly Thr Cys Cys Gly Cys Gly Cys Cys Gly 
            580                 585                 590         


Gly Gly Gly Cys Gly Thr Cys Cys Thr Gly Gly Gly Gly Ala Thr Cys 
        595                 600                 605             


Cys Cys Cys Gly Cys Cys Thr Gly Cys Cys Thr Gly Cys Cys Cys Cys 
    610                 615                 620                 


Gly Gly Ala Gly Cys Cys Cys Gly Ala Gly Cys Thr Gly Cys Ala Cys 
625                 630                 635                 640 


Cys Cys Gly Ala Gly Cys Cys Gly Cys Gly Cys Gly Ala Cys Cys Cys 
                645                 650                 655     


Gly Cys Cys Thr Gly Cys Gly Cys Thr Gly Thr Thr Cys Gly Cys Cys 
            660                 665                 670         


Gly Ala Gly Gly Cys Gly Gly Cys Gly Thr Gly Cys Cys Cys Thr Gly 
        675                 680                 685             


Ala Ala Gly Gly Gly Cys Ala Gly Gly Cys Gly Ala Thr Gly Gly Ala 
    690                 695                 700                 


Gly Cys Cys Ala Ala Gly Cys Cys Cys Ala Cys Cys Gly Thr Cys Cys 
705                 710                 715                 720 


Cys Cys Gly Cys Thr Cys Cys Thr Thr Cys Cys Gly Gly Gly Cys Gly 
                725                 730                 735     


Ala Cys Gly Thr Gly Cys Thr Gly Gly Cys Thr Cys Thr Gly Thr Thr 
            740                 745                 750         


Gly Gly Ala Gly Ala Cys Cys Thr Gly Gly Ala Thr Gly Cys Cys Cys 
        755                 760                 765             


Cys Thr Cys Thr Cys Gly Cys Cys Thr Cys Thr Gly Gly Ala Gly Thr 
    770                 775                 780                 


Gly Gly Cys Thr Gly Cys Cys Thr Gly Ala Gly Gly Ala Gly Cys Cys 
785                 790                 795                 800 


Cys Ala Ala Gly Thr Gly Ala 
                805         


<210>  20
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  20
ctatataaat ag                                                           12


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  21

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  22
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  22

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  23
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  23

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  24
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  24

Lys Ala Leu Ala Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala 
1               5                   10                  15      


Leu Ala Lys His Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Cys Glu 
            20                  25                  30          


Ala 
    


<210>  25
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  25

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  26
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  26

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  27
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  27

Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10      


<210>  28
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  28

Thr His Arg Leu Pro Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  29
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  29

Gly Gly Arg Arg Ala Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  30
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ser Asp Lys Pro Asp Met Ala Glu Ile Glu Lys Phe Asp Lys Ser 
1               5                   10                  15      


Lys Leu Lys Lys Thr Glu Thr Gln Glu Lys Asn Pro Leu Pro Ser Lys 
            20                  25                  30          


Glu Thr Ile Glu Gln Glu Lys Gln Ala Gly Glu Ser 
        35                  40                  


<210>  31
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  31

Gly Gly Gly Ala Gly Gly Ala Ala Thr Gly Thr Gly Thr Thr Thr Ala 
1               5                   10                  15      


Ala Gly Gly Ala Thr Thr Ala Ala Ala Ala Ala 
            20                  25          


<210>  32
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  32

Thr Ala Cys Ala Ala Ala Ala Cys Ala Thr Cys Cys Cys Ala Cys Cys 
1               5                   10                  15      


Cys Cys Ala Ala Ala Cys Cys Thr Cys 
            20                  25  


<210>  33
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  33
attggttgtt tgtggttttg gtggt                                             25


<210>  34
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  34
taaaaacatt tcccccaaac tccccc                                            26


<210>  35
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  35
aattagggga gttgggtatt agttaag                                           27


<210>  36
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  36
cccacttcaa aaatataaaa aaaataaaaa                                        30


