                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Giacomini, Kathleen M.
       More, Swati
 
<120>  Platinum Anticancer Agents

<130>  84850-013510PC-846113

<150>  US 61/528,136
<151>  2011-08-26

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  1665
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA which is cDNA of mRNA encoding Homo sapiens solute 
       carrier family 22, member 1 (SLC22A1), transcript variant 1


<220>
<221>  CDS
<222>  (1)..(1665)

<400>  1
atg ccc acc gtg gat gac att ctg gag cag gtt ggg gag tct ggc tgg         48
Met Pro Thr Val Asp Asp Ile Leu Glu Gln Val Gly Glu Ser Gly Trp           
1               5                   10                  15                

ttc cag aag caa gcc ttc ctc atc tta tgc ctg ctg tcg gct gcc ttt         96
Phe Gln Lys Gln Ala Phe Leu Ile Leu Cys Leu Leu Ser Ala Ala Phe           
            20                  25                  30                    

gcg ccc atc tgt gtg ggc atc gtc ttc ctg ggt ttc aca cct gac cac        144
Ala Pro Ile Cys Val Gly Ile Val Phe Leu Gly Phe Thr Pro Asp His           
        35                  40                  45                        

cac tgc cag agt cct ggg gtg gct gag ctg agc cag cgc tgt ggc tgg        192
His Cys Gln Ser Pro Gly Val Ala Glu Leu Ser Gln Arg Cys Gly Trp           
    50                  55                  60                            

agc cct gcg gag gag ctg aac tat aca gtg cca ggc ctg ggg ccc gcg        240
Ser Pro Ala Glu Glu Leu Asn Tyr Thr Val Pro Gly Leu Gly Pro Ala           
65                  70                  75                  80            

ggc gag gcc ttc ctt ggc cag tgc agg cgc tat gaa gtg gac tgg aac        288
Gly Glu Ala Phe Leu Gly Gln Cys Arg Arg Tyr Glu Val Asp Trp Asn           
                85                  90                  95                

cag agc gcc ctc agc tgt gta gac ccc ctg gct agc ctg gcc acc aac        336
Gln Ser Ala Leu Ser Cys Val Asp Pro Leu Ala Ser Leu Ala Thr Asn           
            100                 105                 110                   

agg agc cac ctg ccg ctg ggt ccc tgc cag gat ggc tgg gtg tat gac        384
Arg Ser His Leu Pro Leu Gly Pro Cys Gln Asp Gly Trp Val Tyr Asp           
        115                 120                 125                       

acg ccc ggc tct tcc atc gtc act gag ttc aac ctg gtg tgt gct gac        432
Thr Pro Gly Ser Ser Ile Val Thr Glu Phe Asn Leu Val Cys Ala Asp           
    130                 135                 140                           

tcc tgg aag ctg gac ctc ttt cag tcc tgt ttg aat gcg ggc ttc ttg        480
Ser Trp Lys Leu Asp Leu Phe Gln Ser Cys Leu Asn Ala Gly Phe Leu           
145                 150                 155                 160           

ttt ggc tct ctc ggt gtt ggc tac ttt gca gac agg ttt ggc cgt aag        528
Phe Gly Ser Leu Gly Val Gly Tyr Phe Ala Asp Arg Phe Gly Arg Lys           
                165                 170                 175               

ctg tgt ctc ctg gga act gtg ctg gtc aac gcg gtg tcg ggc gtg ctc        576
Leu Cys Leu Leu Gly Thr Val Leu Val Asn Ala Val Ser Gly Val Leu           
            180                 185                 190                   

atg gcc ttc tcg ccc aac tac atg tcc atg ctg ctc ttc cgc ctg ctg        624
Met Ala Phe Ser Pro Asn Tyr Met Ser Met Leu Leu Phe Arg Leu Leu           
        195                 200                 205                       

cag ggc ctg gtc agc aag ggc aac tgg atg gct ggc tac acc cta atc        672
Gln Gly Leu Val Ser Lys Gly Asn Trp Met Ala Gly Tyr Thr Leu Ile           
    210                 215                 220                           

aca gaa ttt gtt ggc tcg ggc tcc aga aga acg gtg gcg atc atg tac        720
Thr Glu Phe Val Gly Ser Gly Ser Arg Arg Thr Val Ala Ile Met Tyr           
225                 230                 235                 240           

cag atg gcc ttc acg gtg ggg ctg gtg gcg ctt acc ggg ctg gcc tac        768
Gln Met Ala Phe Thr Val Gly Leu Val Ala Leu Thr Gly Leu Ala Tyr           
                245                 250                 255               

gcc ctg cct cac tgg cgc tgg ctg cag ctg gca gtc tcc ctg ccc acc        816
Ala Leu Pro His Trp Arg Trp Leu Gln Leu Ala Val Ser Leu Pro Thr           
            260                 265                 270                   

ttc ctc ttc ctg ctc tac tac tgg tgt gtg ccg gag tcc cct cgg tgg        864
Phe Leu Phe Leu Leu Tyr Tyr Trp Cys Val Pro Glu Ser Pro Arg Trp           
        275                 280                 285                       

ctg tta tca caa aaa aga aac act gaa gca ata aag ata atg gac cac        912
Leu Leu Ser Gln Lys Arg Asn Thr Glu Ala Ile Lys Ile Met Asp His           
    290                 295                 300                           

atc gct caa aag aat ggg aag ttg cct cct gct gat tta aag atg ctt        960
Ile Ala Gln Lys Asn Gly Lys Leu Pro Pro Ala Asp Leu Lys Met Leu           
305                 310                 315                 320           

tcc ctc gaa gag gat gtc acc gaa aag ctg agc cct tca ttt gca gac       1008
Ser Leu Glu Glu Asp Val Thr Glu Lys Leu Ser Pro Ser Phe Ala Asp           
                325                 330                 335               

ctg ttc cgc acg ccg cgc ctg agg aag cgc acc ttc atc ctg atg tac       1056
Leu Phe Arg Thr Pro Arg Leu Arg Lys Arg Thr Phe Ile Leu Met Tyr           
            340                 345                 350                   

ctg tgg ttc acg gac tct gtg ctc tat cag ggg ctc atc ctg cac atg       1104
Leu Trp Phe Thr Asp Ser Val Leu Tyr Gln Gly Leu Ile Leu His Met           
        355                 360                 365                       

ggc gcc acc agc ggg aac ctc tac ctg gat ttc ctt tac tcc gct ctg       1152
Gly Ala Thr Ser Gly Asn Leu Tyr Leu Asp Phe Leu Tyr Ser Ala Leu           
    370                 375                 380                           

gtc gaa atc ccg ggg gcc ttc ata gcc ctc atc acc att gac cgc gtg       1200
Val Glu Ile Pro Gly Ala Phe Ile Ala Leu Ile Thr Ile Asp Arg Val           
385                 390                 395                 400           

ggc cgc atc tac ccc atg gcc atg tca aat ttg ttg gcg ggg gca gcc       1248
Gly Arg Ile Tyr Pro Met Ala Met Ser Asn Leu Leu Ala Gly Ala Ala           
                405                 410                 415               

tgc ctc gtc atg att ttt atc tca cct gac ctg cac tgg tta aac atc       1296
Cys Leu Val Met Ile Phe Ile Ser Pro Asp Leu His Trp Leu Asn Ile           
            420                 425                 430                   

ata atc atg tgt gtt ggc cga atg gga atc acc att gca ata caa atg       1344
Ile Ile Met Cys Val Gly Arg Met Gly Ile Thr Ile Ala Ile Gln Met           
        435                 440                 445                       

atc tgc ctg gtg aat gct gag ctg tac ccc aca ttc gtc agg aac ctc       1392
Ile Cys Leu Val Asn Ala Glu Leu Tyr Pro Thr Phe Val Arg Asn Leu           
    450                 455                 460                           

gga gtg atg gtg tgt tcc tcc ctg tgt gac ata ggt ggg ata atc acc       1440
Gly Val Met Val Cys Ser Ser Leu Cys Asp Ile Gly Gly Ile Ile Thr           
465                 470                 475                 480           

ccc ttc ata gtc ttc agg ctg agg gag gtc tgg caa gcc ttg ccc ctc       1488
Pro Phe Ile Val Phe Arg Leu Arg Glu Val Trp Gln Ala Leu Pro Leu           
                485                 490                 495               

att ttg ttt gcg gtg ttg ggc ctg ctt gcc gcg gga gtg acg cta ctt       1536
Ile Leu Phe Ala Val Leu Gly Leu Leu Ala Ala Gly Val Thr Leu Leu           
            500                 505                 510                   

ctt cca gag acc aag ggg gtc gct ttg cca gag acc atg aag gac gcc       1584
Leu Pro Glu Thr Lys Gly Val Ala Leu Pro Glu Thr Met Lys Asp Ala           
        515                 520                 525                       

gag aac ctt ggg aga aaa gca aag ccc aaa gaa aac acg att tac ctt       1632
Glu Asn Leu Gly Arg Lys Ala Lys Pro Lys Glu Asn Thr Ile Tyr Leu           
    530                 535                 540                           

aag gtc caa acc tca gaa ccc tcg ggc acc tga                           1665
Lys Val Gln Thr Ser Glu Pro Ser Gly Thr                                   
545                 550                                                   


<210>  2
<211>  554
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Pro Thr Val Asp Asp Ile Leu Glu Gln Val Gly Glu Ser Gly Trp 
1               5                   10                  15      


Phe Gln Lys Gln Ala Phe Leu Ile Leu Cys Leu Leu Ser Ala Ala Phe 
            20                  25                  30          


Ala Pro Ile Cys Val Gly Ile Val Phe Leu Gly Phe Thr Pro Asp His 
        35                  40                  45              


His Cys Gln Ser Pro Gly Val Ala Glu Leu Ser Gln Arg Cys Gly Trp 
    50                  55                  60                  


Ser Pro Ala Glu Glu Leu Asn Tyr Thr Val Pro Gly Leu Gly Pro Ala 
65                  70                  75                  80  


Gly Glu Ala Phe Leu Gly Gln Cys Arg Arg Tyr Glu Val Asp Trp Asn 
                85                  90                  95      


Gln Ser Ala Leu Ser Cys Val Asp Pro Leu Ala Ser Leu Ala Thr Asn 
            100                 105                 110         


Arg Ser His Leu Pro Leu Gly Pro Cys Gln Asp Gly Trp Val Tyr Asp 
        115                 120                 125             


Thr Pro Gly Ser Ser Ile Val Thr Glu Phe Asn Leu Val Cys Ala Asp 
    130                 135                 140                 


Ser Trp Lys Leu Asp Leu Phe Gln Ser Cys Leu Asn Ala Gly Phe Leu 
145                 150                 155                 160 


Phe Gly Ser Leu Gly Val Gly Tyr Phe Ala Asp Arg Phe Gly Arg Lys 
                165                 170                 175     


Leu Cys Leu Leu Gly Thr Val Leu Val Asn Ala Val Ser Gly Val Leu 
            180                 185                 190         


Met Ala Phe Ser Pro Asn Tyr Met Ser Met Leu Leu Phe Arg Leu Leu 
        195                 200                 205             


Gln Gly Leu Val Ser Lys Gly Asn Trp Met Ala Gly Tyr Thr Leu Ile 
    210                 215                 220                 


Thr Glu Phe Val Gly Ser Gly Ser Arg Arg Thr Val Ala Ile Met Tyr 
225                 230                 235                 240 


Gln Met Ala Phe Thr Val Gly Leu Val Ala Leu Thr Gly Leu Ala Tyr 
                245                 250                 255     


Ala Leu Pro His Trp Arg Trp Leu Gln Leu Ala Val Ser Leu Pro Thr 
            260                 265                 270         


Phe Leu Phe Leu Leu Tyr Tyr Trp Cys Val Pro Glu Ser Pro Arg Trp 
        275                 280                 285             


Leu Leu Ser Gln Lys Arg Asn Thr Glu Ala Ile Lys Ile Met Asp His 
    290                 295                 300                 


Ile Ala Gln Lys Asn Gly Lys Leu Pro Pro Ala Asp Leu Lys Met Leu 
305                 310                 315                 320 


Ser Leu Glu Glu Asp Val Thr Glu Lys Leu Ser Pro Ser Phe Ala Asp 
                325                 330                 335     


Leu Phe Arg Thr Pro Arg Leu Arg Lys Arg Thr Phe Ile Leu Met Tyr 
            340                 345                 350         


Leu Trp Phe Thr Asp Ser Val Leu Tyr Gln Gly Leu Ile Leu His Met 
        355                 360                 365             


Gly Ala Thr Ser Gly Asn Leu Tyr Leu Asp Phe Leu Tyr Ser Ala Leu 
    370                 375                 380                 


Val Glu Ile Pro Gly Ala Phe Ile Ala Leu Ile Thr Ile Asp Arg Val 
385                 390                 395                 400 


Gly Arg Ile Tyr Pro Met Ala Met Ser Asn Leu Leu Ala Gly Ala Ala 
                405                 410                 415     


Cys Leu Val Met Ile Phe Ile Ser Pro Asp Leu His Trp Leu Asn Ile 
            420                 425                 430         


Ile Ile Met Cys Val Gly Arg Met Gly Ile Thr Ile Ala Ile Gln Met 
        435                 440                 445             


Ile Cys Leu Val Asn Ala Glu Leu Tyr Pro Thr Phe Val Arg Asn Leu 
    450                 455                 460                 


Gly Val Met Val Cys Ser Ser Leu Cys Asp Ile Gly Gly Ile Ile Thr 
465                 470                 475                 480 


Pro Phe Ile Val Phe Arg Leu Arg Glu Val Trp Gln Ala Leu Pro Leu 
                485                 490                 495     


Ile Leu Phe Ala Val Leu Gly Leu Leu Ala Ala Gly Val Thr Leu Leu 
            500                 505                 510         


Leu Pro Glu Thr Lys Gly Val Ala Leu Pro Glu Thr Met Lys Asp Ala 
        515                 520                 525             


Glu Asn Leu Gly Arg Lys Ala Lys Pro Lys Glu Asn Thr Ile Tyr Leu 
    530                 535                 540                 


Lys Val Gln Thr Ser Glu Pro Ser Gly Thr 
545                 550                 


<210>  3
<211>  1668
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA which is cDNA of mRNA encoding Homo sapiens solute 
       carrier family 22, member 2 (SLC22A2)


<220>
<221>  CDS
<222>  (1)..(1668)

<400>  3
atg ccc acc acc gtg gac gat gtc ctg gag cat gga ggg gag ttt cac         48
Met Pro Thr Thr Val Asp Asp Val Leu Glu His Gly Gly Glu Phe His           
1               5                   10                  15                

ttt ttc cag aag caa atg ttt ttc ctc ttg gct ctg ctc tcg gct acc         96
Phe Phe Gln Lys Gln Met Phe Phe Leu Leu Ala Leu Leu Ser Ala Thr           
            20                  25                  30                    

ttc gcg ccc atc tac gtg ggc atc gtc ttc ctg ggc ttc acc cct gac        144
Phe Ala Pro Ile Tyr Val Gly Ile Val Phe Leu Gly Phe Thr Pro Asp           
        35                  40                  45                        

cac cgc tgc cgg agc ccc gga gtg gcc gag ctg agt ctg cgc tgc ggc        192
His Arg Cys Arg Ser Pro Gly Val Ala Glu Leu Ser Leu Arg Cys Gly           
    50                  55                  60                            

tgg agt cct gca gag gaa ctg aac tac acg gtg ccg ggc cca gga cct        240
Trp Ser Pro Ala Glu Glu Leu Asn Tyr Thr Val Pro Gly Pro Gly Pro           
65                  70                  75                  80            

gcg ggc gaa gcc tcc cca aga cag tgt agg cgc tac gag gtg gac tgg        288
Ala Gly Glu Ala Ser Pro Arg Gln Cys Arg Arg Tyr Glu Val Asp Trp           
                85                  90                  95                

aac cag agc acc ttc gac tgc gtg gac ccc ctg gcc agc ctg gac acc        336
Asn Gln Ser Thr Phe Asp Cys Val Asp Pro Leu Ala Ser Leu Asp Thr           
            100                 105                 110                   

aac agg agc cgc ctg cca ctg ggc ccc tgc cgg gac ggc tgg gtg tac        384
Asn Arg Ser Arg Leu Pro Leu Gly Pro Cys Arg Asp Gly Trp Val Tyr           
        115                 120                 125                       

gag acg cct ggc tcg tcc atc gtc acc gag ttt aac ctg gta tgt gcc        432
Glu Thr Pro Gly Ser Ser Ile Val Thr Glu Phe Asn Leu Val Cys Ala           
    130                 135                 140                           

aac tcc tgg atg ttg gac cta ttc cag tca tca gtg aat gta gga ttc        480
Asn Ser Trp Met Leu Asp Leu Phe Gln Ser Ser Val Asn Val Gly Phe           
145                 150                 155                 160           

ttt att ggc tct atg agt atc ggc tac ata gca gac agg ttt ggc cgt        528
Phe Ile Gly Ser Met Ser Ile Gly Tyr Ile Ala Asp Arg Phe Gly Arg           
                165                 170                 175               

aag ctc tgc ctc cta act aca gtc ctc ata aat gct gca gct gga gtt        576
Lys Leu Cys Leu Leu Thr Thr Val Leu Ile Asn Ala Ala Ala Gly Val           
            180                 185                 190                   

ctc atg gcc att tcc cca acc tat acg tgg atg tta att ttt cgc tta        624
Leu Met Ala Ile Ser Pro Thr Tyr Thr Trp Met Leu Ile Phe Arg Leu           
        195                 200                 205                       

atc caa gga ctg gtc agc aaa gca ggc tgg tta ata ggc tac atc ctg        672
Ile Gln Gly Leu Val Ser Lys Ala Gly Trp Leu Ile Gly Tyr Ile Leu           
    210                 215                 220                           

att aca gaa ttt gtt ggg cgg aga tat cgg aga aca gtg ggg att ttt        720
Ile Thr Glu Phe Val Gly Arg Arg Tyr Arg Arg Thr Val Gly Ile Phe           
225                 230                 235                 240           

tac caa gtt gcc tat aca gtt ggg ctc ctg gtg cta gct ggg gtg gct        768
Tyr Gln Val Ala Tyr Thr Val Gly Leu Leu Val Leu Ala Gly Val Ala           
                245                 250                 255               

tac gca ctt cct cac tgg agg tgg ttg cag ttc aca gtt tct ctg ccc        816
Tyr Ala Leu Pro His Trp Arg Trp Leu Gln Phe Thr Val Ser Leu Pro           
            260                 265                 270                   

aac ttc ttc ttc ttg ctc tat tac tgg tgc ata cct gag tct ccc agg        864
Asn Phe Phe Phe Leu Leu Tyr Tyr Trp Cys Ile Pro Glu Ser Pro Arg           
        275                 280                 285                       

tgg ctg atc tcc cag aat aag aat gct gaa gcc atg aga atc att aag        912
Trp Leu Ile Ser Gln Asn Lys Asn Ala Glu Ala Met Arg Ile Ile Lys           
    290                 295                 300                           

cac atc gca aag aaa aat gga aaa tct cta ccc gcc tcc ctt cag cgc        960
His Ile Ala Lys Lys Asn Gly Lys Ser Leu Pro Ala Ser Leu Gln Arg           
305                 310                 315                 320           

ctg aga ctt gaa gag gaa act ggc aag aaa ttg aac cct tca ttt ctt       1008
Leu Arg Leu Glu Glu Glu Thr Gly Lys Lys Leu Asn Pro Ser Phe Leu           
                325                 330                 335               

gac ttg gtc aga act cct cag ata agg aaa cat act atg ata ttg atg       1056
Asp Leu Val Arg Thr Pro Gln Ile Arg Lys His Thr Met Ile Leu Met           
            340                 345                 350                   

tac aac tgg ttc acg agc tct gtg ctc tac cag ggc ctc atc atg cac       1104
Tyr Asn Trp Phe Thr Ser Ser Val Leu Tyr Gln Gly Leu Ile Met His           
        355                 360                 365                       

atg ggc ctt gca ggt gac aat atc tac ctg gat ttc ttc tac tct gcc       1152
Met Gly Leu Ala Gly Asp Asn Ile Tyr Leu Asp Phe Phe Tyr Ser Ala           
    370                 375                 380                           

ctg gtt gaa ttc cca gct gcc ttc atg atc atc ctc acc atc gac cgc       1200
Leu Val Glu Phe Pro Ala Ala Phe Met Ile Ile Leu Thr Ile Asp Arg           
385                 390                 395                 400           

atc gga cgc cgt tac cct tgg gct gca tca aat atg gtt gca ggg gca       1248
Ile Gly Arg Arg Tyr Pro Trp Ala Ala Ser Asn Met Val Ala Gly Ala           
                405                 410                 415               

gcc tgt ctg gcc tca gtt ttt ata cct ggt gat cta caa tgg cta aaa       1296
Ala Cys Leu Ala Ser Val Phe Ile Pro Gly Asp Leu Gln Trp Leu Lys           
            420                 425                 430                   

att att atc tca tgc ttg gga aga atg ggg atc aca atg gcc tat gag       1344
Ile Ile Ile Ser Cys Leu Gly Arg Met Gly Ile Thr Met Ala Tyr Glu           
        435                 440                 445                       

ata gtc tgc ctg gtc aat gct gag ctg tac ccc aca ttc att agg aat       1392
Ile Val Cys Leu Val Asn Ala Glu Leu Tyr Pro Thr Phe Ile Arg Asn           
    450                 455                 460                           

ctt ggc gtc cac atc tgt tcc tca atg tgt gac att ggt ggc atc atc       1440
Leu Gly Val His Ile Cys Ser Ser Met Cys Asp Ile Gly Gly Ile Ile           
465                 470                 475                 480           

acg cca ttc ctg gtc tac cgg ctc act aac atc tgg ctt gag ctc ccg       1488
Thr Pro Phe Leu Val Tyr Arg Leu Thr Asn Ile Trp Leu Glu Leu Pro           
                485                 490                 495               

ctg atg gtt ttc ggc gtg ctt ggc ttg gtt gct gga ggt ctg gtg ctg       1536
Leu Met Val Phe Gly Val Leu Gly Leu Val Ala Gly Gly Leu Val Leu           
            500                 505                 510                   

ttg ctt cca gaa act aaa ggg aaa gct ttg cct gag acc atc gag gaa       1584
Leu Leu Pro Glu Thr Lys Gly Lys Ala Leu Pro Glu Thr Ile Glu Glu           
        515                 520                 525                       

gcc gaa aat atg caa aga cca aga aaa aat aaa gaa aag atg att tac       1632
Ala Glu Asn Met Gln Arg Pro Arg Lys Asn Lys Glu Lys Met Ile Tyr           
    530                 535                 540                           

ctc caa gtt cag aaa cta gac att cca ttg aac taa                       1668
Leu Gln Val Gln Lys Leu Asp Ile Pro Leu Asn                               
545                 550                 555                               


<210>  4
<211>  555
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  4

Met Pro Thr Thr Val Asp Asp Val Leu Glu His Gly Gly Glu Phe His 
1               5                   10                  15      


Phe Phe Gln Lys Gln Met Phe Phe Leu Leu Ala Leu Leu Ser Ala Thr 
            20                  25                  30          


Phe Ala Pro Ile Tyr Val Gly Ile Val Phe Leu Gly Phe Thr Pro Asp 
        35                  40                  45              


His Arg Cys Arg Ser Pro Gly Val Ala Glu Leu Ser Leu Arg Cys Gly 
    50                  55                  60                  


Trp Ser Pro Ala Glu Glu Leu Asn Tyr Thr Val Pro Gly Pro Gly Pro 
65                  70                  75                  80  


Ala Gly Glu Ala Ser Pro Arg Gln Cys Arg Arg Tyr Glu Val Asp Trp 
                85                  90                  95      


Asn Gln Ser Thr Phe Asp Cys Val Asp Pro Leu Ala Ser Leu Asp Thr 
            100                 105                 110         


Asn Arg Ser Arg Leu Pro Leu Gly Pro Cys Arg Asp Gly Trp Val Tyr 
        115                 120                 125             


Glu Thr Pro Gly Ser Ser Ile Val Thr Glu Phe Asn Leu Val Cys Ala 
    130                 135                 140                 


Asn Ser Trp Met Leu Asp Leu Phe Gln Ser Ser Val Asn Val Gly Phe 
145                 150                 155                 160 


Phe Ile Gly Ser Met Ser Ile Gly Tyr Ile Ala Asp Arg Phe Gly Arg 
                165                 170                 175     


Lys Leu Cys Leu Leu Thr Thr Val Leu Ile Asn Ala Ala Ala Gly Val 
            180                 185                 190         


Leu Met Ala Ile Ser Pro Thr Tyr Thr Trp Met Leu Ile Phe Arg Leu 
        195                 200                 205             


Ile Gln Gly Leu Val Ser Lys Ala Gly Trp Leu Ile Gly Tyr Ile Leu 
    210                 215                 220                 


Ile Thr Glu Phe Val Gly Arg Arg Tyr Arg Arg Thr Val Gly Ile Phe 
225                 230                 235                 240 


Tyr Gln Val Ala Tyr Thr Val Gly Leu Leu Val Leu Ala Gly Val Ala 
                245                 250                 255     


Tyr Ala Leu Pro His Trp Arg Trp Leu Gln Phe Thr Val Ser Leu Pro 
            260                 265                 270         


Asn Phe Phe Phe Leu Leu Tyr Tyr Trp Cys Ile Pro Glu Ser Pro Arg 
        275                 280                 285             


Trp Leu Ile Ser Gln Asn Lys Asn Ala Glu Ala Met Arg Ile Ile Lys 
    290                 295                 300                 


His Ile Ala Lys Lys Asn Gly Lys Ser Leu Pro Ala Ser Leu Gln Arg 
305                 310                 315                 320 


Leu Arg Leu Glu Glu Glu Thr Gly Lys Lys Leu Asn Pro Ser Phe Leu 
                325                 330                 335     


Asp Leu Val Arg Thr Pro Gln Ile Arg Lys His Thr Met Ile Leu Met 
            340                 345                 350         


Tyr Asn Trp Phe Thr Ser Ser Val Leu Tyr Gln Gly Leu Ile Met His 
        355                 360                 365             


Met Gly Leu Ala Gly Asp Asn Ile Tyr Leu Asp Phe Phe Tyr Ser Ala 
    370                 375                 380                 


Leu Val Glu Phe Pro Ala Ala Phe Met Ile Ile Leu Thr Ile Asp Arg 
385                 390                 395                 400 


Ile Gly Arg Arg Tyr Pro Trp Ala Ala Ser Asn Met Val Ala Gly Ala 
                405                 410                 415     


Ala Cys Leu Ala Ser Val Phe Ile Pro Gly Asp Leu Gln Trp Leu Lys 
            420                 425                 430         


Ile Ile Ile Ser Cys Leu Gly Arg Met Gly Ile Thr Met Ala Tyr Glu 
        435                 440                 445             


Ile Val Cys Leu Val Asn Ala Glu Leu Tyr Pro Thr Phe Ile Arg Asn 
    450                 455                 460                 


Leu Gly Val His Ile Cys Ser Ser Met Cys Asp Ile Gly Gly Ile Ile 
465                 470                 475                 480 


Thr Pro Phe Leu Val Tyr Arg Leu Thr Asn Ile Trp Leu Glu Leu Pro 
                485                 490                 495     


Leu Met Val Phe Gly Val Leu Gly Leu Val Ala Gly Gly Leu Val Leu 
            500                 505                 510         


Leu Leu Pro Glu Thr Lys Gly Lys Ala Leu Pro Glu Thr Ile Glu Glu 
        515                 520                 525             


Ala Glu Asn Met Gln Arg Pro Arg Lys Asn Lys Glu Lys Met Ile Tyr 
    530                 535                 540                 


Leu Gln Val Gln Lys Leu Asp Ile Pro Leu Asn 
545                 550                 555 


<210>  5
<211>  1671
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA which is cDNA of mRNA encoding Homo sapiens solute 
       carrier family 22, member 3 (SLC22A3)


<220>
<221>  CDS
<222>  (1)..(1671)

<400>  5
atg ccc tcc ttc gac gag gcg ctg cag cgg gtg ggc gag ttc ggg cgc         48
Met Pro Ser Phe Asp Glu Ala Leu Gln Arg Val Gly Glu Phe Gly Arg           
1               5                   10                  15                

ttc cag agg cgc gtg ttt ttg ctg ctg tgc ctg acg ggc gtc acc ttc         96
Phe Gln Arg Arg Val Phe Leu Leu Leu Cys Leu Thr Gly Val Thr Phe           
            20                  25                  30                    

gcc ttc ctc ttc gtc ggc gtg gtc ttc ctg ggc acg cag ccc gac cac        144
Ala Phe Leu Phe Val Gly Val Val Phe Leu Gly Thr Gln Pro Asp His           
        35                  40                  45                        

tac tgg tgc cgc ggg cca agt gcc gcg gcg ctg gcc gag cgc tgc ggc        192
Tyr Trp Cys Arg Gly Pro Ser Ala Ala Ala Leu Ala Glu Arg Cys Gly           
    50                  55                  60                            

tgg agc ccg gag gag gag tgg aac cgc acg gcg ccc gcc tcc cgc ggc        240
Trp Ser Pro Glu Glu Glu Trp Asn Arg Thr Ala Pro Ala Ser Arg Gly           
65                  70                  75                  80            

cca gag ccc ccc gag cgc cgc ggc cgc tgc cag cgc tac ctc ctg gag        288
Pro Glu Pro Pro Glu Arg Arg Gly Arg Cys Gln Arg Tyr Leu Leu Glu           
                85                  90                  95                

gcg gcc aac gac agc gcc tcc gcc act agc gct ctc agc tgc gcg gac        336
Ala Ala Asn Asp Ser Ala Ser Ala Thr Ser Ala Leu Ser Cys Ala Asp           
            100                 105                 110                   

cca ctc gcc gcc ttc ccc aac cgt tcg gct ccc ctt gtg ccg tgc cgc        384
Pro Leu Ala Ala Phe Pro Asn Arg Ser Ala Pro Leu Val Pro Cys Arg           
        115                 120                 125                       

ggc ggc tgg cgc tac gcc cag gcc cac tcc acc atc gtc agc gag ttt        432
Gly Gly Trp Arg Tyr Ala Gln Ala His Ser Thr Ile Val Ser Glu Phe           
    130                 135                 140                           

gac ctt gtc tgt gtc aat gcg tgg atg ctg gac ctc acc caa gcc atc        480
Asp Leu Val Cys Val Asn Ala Trp Met Leu Asp Leu Thr Gln Ala Ile           
145                 150                 155                 160           

ctg aac ctc ggc ttc ctg act gga gca ttc acc tta ggc tat gca gca        528
Leu Asn Leu Gly Phe Leu Thr Gly Ala Phe Thr Leu Gly Tyr Ala Ala           
                165                 170                 175               

gac agg tat ggc agg atc gtc att tac ttg cta tcc tgc ctt ggt gtt        576
Asp Arg Tyr Gly Arg Ile Val Ile Tyr Leu Leu Ser Cys Leu Gly Val           
            180                 185                 190                   

ggc gtc act ggg gtt gtg gtg gcc ttt gca cca aac ttc cct gtg ttt        624
Gly Val Thr Gly Val Val Val Ala Phe Ala Pro Asn Phe Pro Val Phe           
        195                 200                 205                       

gtg atc ttc cgc ttc ctg caa ggt gta ttt gga aag ggg acg tgg atg        672
Val Ile Phe Arg Phe Leu Gln Gly Val Phe Gly Lys Gly Thr Trp Met           
    210                 215                 220                           

act tgc tac gtg att gtg aca gaa ata gta ggt tcg aaa caa agg agg        720
Thr Cys Tyr Val Ile Val Thr Glu Ile Val Gly Ser Lys Gln Arg Arg           
225                 230                 235                 240           

att gtg gga atc gtg att caa atg ttc ttt acc ctt gga atc ata att        768
Ile Val Gly Ile Val Ile Gln Met Phe Phe Thr Leu Gly Ile Ile Ile           
                245                 250                 255               

ctc cct gga att gcc tac ttc atc ccc aac tgg caa gga atc cag tta        816
Leu Pro Gly Ile Ala Tyr Phe Ile Pro Asn Trp Gln Gly Ile Gln Leu           
            260                 265                 270                   

gcc atc acg ctg ccc agc ttt ctc ttc ctc ctt tat tac tgg gtg gtc        864
Ala Ile Thr Leu Pro Ser Phe Leu Phe Leu Leu Tyr Tyr Trp Val Val           
        275                 280                 285                       

cct gag tct ccc cgt tgg ctg att act cgg aag aaa gga gat aaa gca        912
Pro Glu Ser Pro Arg Trp Leu Ile Thr Arg Lys Lys Gly Asp Lys Ala           
    290                 295                 300                           

tta cag atc ctg aga cgc att gct aag tgc aat ggg aaa tac ctc tca        960
Leu Gln Ile Leu Arg Arg Ile Ala Lys Cys Asn Gly Lys Tyr Leu Ser           
305                 310                 315                 320           

tca aat tac tca gag atc act gtt aca gat gag gaa gtt agt aat cca       1008
Ser Asn Tyr Ser Glu Ile Thr Val Thr Asp Glu Glu Val Ser Asn Pro           
                325                 330                 335               

tcc ttt tta gat ctg gtg aga act ccc caa atg agg aaa tgc aca ctt       1056
Ser Phe Leu Asp Leu Val Arg Thr Pro Gln Met Arg Lys Cys Thr Leu           
            340                 345                 350                   

att ctt atg ttt gct tgg ttc aca agc gca gtg gtg tat caa gga ctt       1104
Ile Leu Met Phe Ala Trp Phe Thr Ser Ala Val Val Tyr Gln Gly Leu           
        355                 360                 365                       

gtc atg cgc ctg gga att ata ggg ggc aac ctc tat ata gac ttt ttc       1152
Val Met Arg Leu Gly Ile Ile Gly Gly Asn Leu Tyr Ile Asp Phe Phe           
    370                 375                 380                           

atc tcg ggc gtg gtg gaa ctg cca gga gct ctc ttg atc tta cta acc       1200
Ile Ser Gly Val Val Glu Leu Pro Gly Ala Leu Leu Ile Leu Leu Thr           
385                 390                 395                 400           

att gag cgc ctt gga cga cgc ctc ccc ttt gcg gca agc aat ata gtg       1248
Ile Glu Arg Leu Gly Arg Arg Leu Pro Phe Ala Ala Ser Asn Ile Val           
                405                 410                 415               

gca ggg gtg gca tgc ctt gtc act gcg ttc tta cca gaa gga ata gca       1296
Ala Gly Val Ala Cys Leu Val Thr Ala Phe Leu Pro Glu Gly Ile Ala           
            420                 425                 430                   

tgg ttg agg acc aca gtg gct aca ttg gga aga cta ggg ata acc atg       1344
Trp Leu Arg Thr Thr Val Ala Thr Leu Gly Arg Leu Gly Ile Thr Met           
        435                 440                 445                       

gcc ttt gaa att gtt tat ttg gta aat tca gaa ttg tac cca aca aca       1392
Ala Phe Glu Ile Val Tyr Leu Val Asn Ser Glu Leu Tyr Pro Thr Thr           
    450                 455                 460                           

tta cga aat ttc gga gtt tcg ctc tgt tca ggt ctg tgt gat ttt ggg       1440
Leu Arg Asn Phe Gly Val Ser Leu Cys Ser Gly Leu Cys Asp Phe Gly           
465                 470                 475                 480           

gga atc ata gcc cca ttt ctg ctc ttt cgg cta gca gcc gtg tgg cta       1488
Gly Ile Ile Ala Pro Phe Leu Leu Phe Arg Leu Ala Ala Val Trp Leu           
                485                 490                 495               

gaa cta cct ctg atc atc ttt ggt atc ctg gca tcc atc tgt ggt ggc       1536
Glu Leu Pro Leu Ile Ile Phe Gly Ile Leu Ala Ser Ile Cys Gly Gly           
            500                 505                 510                   

ctt gtg atg ctt ttg cct gaa acc aag ggt att gcc ttg cca gag aca       1584
Leu Val Met Leu Leu Pro Glu Thr Lys Gly Ile Ala Leu Pro Glu Thr           
        515                 520                 525                       

gtg gat gat gta gaa aaa ctt ggc agt cca cat tcc tgt aaa tgt ggc       1632
Val Asp Asp Val Glu Lys Leu Gly Ser Pro His Ser Cys Lys Cys Gly           
    530                 535                 540                           

agg aat aag aaa acc cca gtt tcc cgc tct cac ctt tga                   1671
Arg Asn Lys Lys Thr Pro Val Ser Arg Ser His Leu                           
545                 550                 555                               


<210>  6
<211>  556
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Pro Ser Phe Asp Glu Ala Leu Gln Arg Val Gly Glu Phe Gly Arg 
1               5                   10                  15      


Phe Gln Arg Arg Val Phe Leu Leu Leu Cys Leu Thr Gly Val Thr Phe 
            20                  25                  30          


Ala Phe Leu Phe Val Gly Val Val Phe Leu Gly Thr Gln Pro Asp His 
        35                  40                  45              


Tyr Trp Cys Arg Gly Pro Ser Ala Ala Ala Leu Ala Glu Arg Cys Gly 
    50                  55                  60                  


Trp Ser Pro Glu Glu Glu Trp Asn Arg Thr Ala Pro Ala Ser Arg Gly 
65                  70                  75                  80  


Pro Glu Pro Pro Glu Arg Arg Gly Arg Cys Gln Arg Tyr Leu Leu Glu 
                85                  90                  95      


Ala Ala Asn Asp Ser Ala Ser Ala Thr Ser Ala Leu Ser Cys Ala Asp 
            100                 105                 110         


Pro Leu Ala Ala Phe Pro Asn Arg Ser Ala Pro Leu Val Pro Cys Arg 
        115                 120                 125             


Gly Gly Trp Arg Tyr Ala Gln Ala His Ser Thr Ile Val Ser Glu Phe 
    130                 135                 140                 


Asp Leu Val Cys Val Asn Ala Trp Met Leu Asp Leu Thr Gln Ala Ile 
145                 150                 155                 160 


Leu Asn Leu Gly Phe Leu Thr Gly Ala Phe Thr Leu Gly Tyr Ala Ala 
                165                 170                 175     


Asp Arg Tyr Gly Arg Ile Val Ile Tyr Leu Leu Ser Cys Leu Gly Val 
            180                 185                 190         


Gly Val Thr Gly Val Val Val Ala Phe Ala Pro Asn Phe Pro Val Phe 
        195                 200                 205             


Val Ile Phe Arg Phe Leu Gln Gly Val Phe Gly Lys Gly Thr Trp Met 
    210                 215                 220                 


Thr Cys Tyr Val Ile Val Thr Glu Ile Val Gly Ser Lys Gln Arg Arg 
225                 230                 235                 240 


Ile Val Gly Ile Val Ile Gln Met Phe Phe Thr Leu Gly Ile Ile Ile 
                245                 250                 255     


Leu Pro Gly Ile Ala Tyr Phe Ile Pro Asn Trp Gln Gly Ile Gln Leu 
            260                 265                 270         


Ala Ile Thr Leu Pro Ser Phe Leu Phe Leu Leu Tyr Tyr Trp Val Val 
        275                 280                 285             


Pro Glu Ser Pro Arg Trp Leu Ile Thr Arg Lys Lys Gly Asp Lys Ala 
    290                 295                 300                 


Leu Gln Ile Leu Arg Arg Ile Ala Lys Cys Asn Gly Lys Tyr Leu Ser 
305                 310                 315                 320 


Ser Asn Tyr Ser Glu Ile Thr Val Thr Asp Glu Glu Val Ser Asn Pro 
                325                 330                 335     


Ser Phe Leu Asp Leu Val Arg Thr Pro Gln Met Arg Lys Cys Thr Leu 
            340                 345                 350         


Ile Leu Met Phe Ala Trp Phe Thr Ser Ala Val Val Tyr Gln Gly Leu 
        355                 360                 365             


Val Met Arg Leu Gly Ile Ile Gly Gly Asn Leu Tyr Ile Asp Phe Phe 
    370                 375                 380                 


Ile Ser Gly Val Val Glu Leu Pro Gly Ala Leu Leu Ile Leu Leu Thr 
385                 390                 395                 400 


Ile Glu Arg Leu Gly Arg Arg Leu Pro Phe Ala Ala Ser Asn Ile Val 
                405                 410                 415     


Ala Gly Val Ala Cys Leu Val Thr Ala Phe Leu Pro Glu Gly Ile Ala 
            420                 425                 430         


Trp Leu Arg Thr Thr Val Ala Thr Leu Gly Arg Leu Gly Ile Thr Met 
        435                 440                 445             


Ala Phe Glu Ile Val Tyr Leu Val Asn Ser Glu Leu Tyr Pro Thr Thr 
    450                 455                 460                 


Leu Arg Asn Phe Gly Val Ser Leu Cys Ser Gly Leu Cys Asp Phe Gly 
465                 470                 475                 480 


Gly Ile Ile Ala Pro Phe Leu Leu Phe Arg Leu Ala Ala Val Trp Leu 
                485                 490                 495     


Glu Leu Pro Leu Ile Ile Phe Gly Ile Leu Ala Ser Ile Cys Gly Gly 
            500                 505                 510         


Leu Val Met Leu Leu Pro Glu Thr Lys Gly Ile Ala Leu Pro Glu Thr 
        515                 520                 525             


Val Asp Asp Val Glu Lys Leu Gly Ser Pro His Ser Cys Lys Cys Gly 
    530                 535                 540                 


Arg Asn Lys Lys Thr Pro Val Ser Arg Ser His Leu 
545                 550                 555     


<210>  7
<211>  1854
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA which is cDNA of mRNA encoding Homo sapiens solute 
       carrier family 6, member 2 (SLC6A2), transcript variant 3


<220>
<221>  CDS
<222>  (1)..(1854)

<400>  7
atg ctt ctg gcg cgg atg aac ccg cag gtg cag ccc gag aac aac ggg         48
Met Leu Leu Ala Arg Met Asn Pro Gln Val Gln Pro Glu Asn Asn Gly           
1               5                   10                  15                

gcg gac acg ggt cca gag cag ccc ctt cgg gcg cgc aaa act gcg gag         96
Ala Asp Thr Gly Pro Glu Gln Pro Leu Arg Ala Arg Lys Thr Ala Glu           
            20                  25                  30                    

ctg ctg gtg gtg aag gag cgc aac ggc gtc cag tgc ctg ctg gcg ccc        144
Leu Leu Val Val Lys Glu Arg Asn Gly Val Gln Cys Leu Leu Ala Pro           
        35                  40                  45                        

cgc gac ggc gac gcg cag ccc cgg gag acc tgg ggc aag aag atc gac        192
Arg Asp Gly Asp Ala Gln Pro Arg Glu Thr Trp Gly Lys Lys Ile Asp           
    50                  55                  60                            

ttc ctg ctg tcc gta gtc ggc ttc gca gtg gac ctg gcc aac gtg tgg        240
Phe Leu Leu Ser Val Val Gly Phe Ala Val Asp Leu Ala Asn Val Trp           
65                  70                  75                  80            

cgc ttc ccc tac ctc tgc tac aag aac ggc ggc ggt gcc ttc ttg atc        288
Arg Phe Pro Tyr Leu Cys Tyr Lys Asn Gly Gly Gly Ala Phe Leu Ile           
                85                  90                  95                

ccg tac aca ctg ttc ctt atc atc gcg ggg atg ccc ctg ttc tac atg        336
Pro Tyr Thr Leu Phe Leu Ile Ile Ala Gly Met Pro Leu Phe Tyr Met           
            100                 105                 110                   

gag ctg gct ctg gga cag tac aac cgg gag ggg gct gcc acc gtt tgg        384
Glu Leu Ala Leu Gly Gln Tyr Asn Arg Glu Gly Ala Ala Thr Val Trp           
        115                 120                 125                       

aaa atc tgc cca ttc ttc aaa ggc gtt ggc tat gct gtc atc ctg atc        432
Lys Ile Cys Pro Phe Phe Lys Gly Val Gly Tyr Ala Val Ile Leu Ile           
    130                 135                 140                           

gcc ctg tac gtt ggc ttc tac tac aac gtc atc atc gcc tgg tca ctc        480
Ala Leu Tyr Val Gly Phe Tyr Tyr Asn Val Ile Ile Ala Trp Ser Leu           
145                 150                 155                 160           

tac tac ctc ttc tcc tcc ttc acc ctc aac ctg ccc tgg acc gac tgt        528
Tyr Tyr Leu Phe Ser Ser Phe Thr Leu Asn Leu Pro Trp Thr Asp Cys           
                165                 170                 175               

ggc cac acc tgg aac agc ccc aac tgt acc gac ccc aag ctc ctc aat        576
Gly His Thr Trp Asn Ser Pro Asn Cys Thr Asp Pro Lys Leu Leu Asn           
            180                 185                 190                   

ggc tcc gtg ctt ggc aac cac acc aag tac tcc aag tac aag ttc acg        624
Gly Ser Val Leu Gly Asn His Thr Lys Tyr Ser Lys Tyr Lys Phe Thr           
        195                 200                 205                       

ccg gca gcc gag ttt tat gag cgt ggt gtc ctg cac ctt cac gag agc        672
Pro Ala Ala Glu Phe Tyr Glu Arg Gly Val Leu His Leu His Glu Ser           
    210                 215                 220                           

agc ggg att cat gac atc ggc ctg ccc cag tgg cag ctc ttg ctc tgt        720
Ser Gly Ile His Asp Ile Gly Leu Pro Gln Trp Gln Leu Leu Leu Cys           
225                 230                 235                 240           

ctg atg gtc gtc gtc atc gtc ttg tat ttt agc ctc tgg aaa ggg gtg        768
Leu Met Val Val Val Ile Val Leu Tyr Phe Ser Leu Trp Lys Gly Val           
                245                 250                 255               

aag aca tca gga aag gtg gtg tgg atc aca gcc acg ctg cct tac ttc        816
Lys Thr Ser Gly Lys Val Val Trp Ile Thr Ala Thr Leu Pro Tyr Phe           
            260                 265                 270                   

gtg ctg ttc gtg ctc ctg gtc cat ggc gtc acg ctg ccc gga gcc tcc        864
Val Leu Phe Val Leu Leu Val His Gly Val Thr Leu Pro Gly Ala Ser           
        275                 280                 285                       

aat ggc atc aat gcc tac ctg cac atc gac ttc tac cgc ttg aaa gag        912
Asn Gly Ile Asn Ala Tyr Leu His Ile Asp Phe Tyr Arg Leu Lys Glu           
    290                 295                 300                           

gcc acg gta tgg att gat gcc gca act cag ata ttt ttt tcc ttg ggg        960
Ala Thr Val Trp Ile Asp Ala Ala Thr Gln Ile Phe Phe Ser Leu Gly           
305                 310                 315                 320           

gct gga ttt gga gta ttg att gca ttt gcc agt tac aac aaa ttt gac       1008
Ala Gly Phe Gly Val Leu Ile Ala Phe Ala Ser Tyr Asn Lys Phe Asp           
                325                 330                 335               

aac aac tgt tac agg gat gcc ctg ctg acc agc agc atc aac tgt atc       1056
Asn Asn Cys Tyr Arg Asp Ala Leu Leu Thr Ser Ser Ile Asn Cys Ile           
            340                 345                 350                   

acc agc ttc gtc tct ggg ttc gcc atc ttc tcc atc ctt ggt tac atg       1104
Thr Ser Phe Val Ser Gly Phe Ala Ile Phe Ser Ile Leu Gly Tyr Met           
        355                 360                 365                       

gcc cat gaa cac aag gtc aac att gag gat gtg gcc aca gaa gga gct       1152
Ala His Glu His Lys Val Asn Ile Glu Asp Val Ala Thr Glu Gly Ala           
    370                 375                 380                           

ggc cta gtg ttc atc ctg tat cca gag gcc att tct acc ctg tct gga       1200
Gly Leu Val Phe Ile Leu Tyr Pro Glu Ala Ile Ser Thr Leu Ser Gly           
385                 390                 395                 400           

tct aca ttc tgg gct gtt gtg ttt ttc gtc atg ctc ctg gcg ctg ggc       1248
Ser Thr Phe Trp Ala Val Val Phe Phe Val Met Leu Leu Ala Leu Gly           
                405                 410                 415               

ctt gac agc tca atg gga ggc atg gag gct gtc atc acg ggc ctg gca       1296
Leu Asp Ser Ser Met Gly Gly Met Glu Ala Val Ile Thr Gly Leu Ala           
            420                 425                 430                   

gat gac ttc cag gtc ctg aag cga cac cgg aaa ctc ttc aca ttt ggc       1344
Asp Asp Phe Gln Val Leu Lys Arg His Arg Lys Leu Phe Thr Phe Gly           
        435                 440                 445                       

gtc acc ttc agc act ttc ctt ctc gcc ctg ttc tgc ata acc aag ggt       1392
Val Thr Phe Ser Thr Phe Leu Leu Ala Leu Phe Cys Ile Thr Lys Gly           
    450                 455                 460                           

gga att tac gtc ttg acc ctc ctg gac acc ttt gct gcg ggc acc tcc       1440
Gly Ile Tyr Val Leu Thr Leu Leu Asp Thr Phe Ala Ala Gly Thr Ser           
465                 470                 475                 480           

atc ctt ttt gct gtc ctc atg gaa gcc atc gga gtt tcc tgg ttt tat       1488
Ile Leu Phe Ala Val Leu Met Glu Ala Ile Gly Val Ser Trp Phe Tyr           
                485                 490                 495               

gga gtg gac agg ttc agc aac gac atc cag cag atg atg ggg ttc agg       1536
Gly Val Asp Arg Phe Ser Asn Asp Ile Gln Gln Met Met Gly Phe Arg           
            500                 505                 510                   

ccg ggt cta tac tgg aga ctg tgc tgg aag ttc gtc agt cct gcc ttc       1584
Pro Gly Leu Tyr Trp Arg Leu Cys Trp Lys Phe Val Ser Pro Ala Phe           
        515                 520                 525                       

ctc ctg ttc gtg gtt gtg gtc agc atc atc aac ttc aag cca ctc acc       1632
Leu Leu Phe Val Val Val Val Ser Ile Ile Asn Phe Lys Pro Leu Thr           
    530                 535                 540                           

tac gac gac tac atc ttc ccg ccc tgg gcc aac tgg gtg ggg tgg ggc       1680
Tyr Asp Asp Tyr Ile Phe Pro Pro Trp Ala Asn Trp Val Gly Trp Gly           
545                 550                 555                 560           

atc gcc ctg tcc tcc atg gtc ctg gtg ccc atc tac gtc atc tat aag       1728
Ile Ala Leu Ser Ser Met Val Leu Val Pro Ile Tyr Val Ile Tyr Lys           
                565                 570                 575               

ttc ctc agc acg cag ggc tct ctt tgg gag aga ctg gcc tat ggc atc       1776
Phe Leu Ser Thr Gln Gly Ser Leu Trp Glu Arg Leu Ala Tyr Gly Ile           
            580                 585                 590                   

acg cca gag aac gag cac cac ctg gtg gct cag agg gac atc aga cag       1824
Thr Pro Glu Asn Glu His His Leu Val Ala Gln Arg Asp Ile Arg Gln           
        595                 600                 605                       

ttc cag ttg caa cac tgg ctg gcc atc tga                               1854
Phe Gln Leu Gln His Trp Leu Ala Ile                                       
    610                 615                                               


<210>  8
<211>  617
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  8

Met Leu Leu Ala Arg Met Asn Pro Gln Val Gln Pro Glu Asn Asn Gly 
1               5                   10                  15      


Ala Asp Thr Gly Pro Glu Gln Pro Leu Arg Ala Arg Lys Thr Ala Glu 
            20                  25                  30          


Leu Leu Val Val Lys Glu Arg Asn Gly Val Gln Cys Leu Leu Ala Pro 
        35                  40                  45              


Arg Asp Gly Asp Ala Gln Pro Arg Glu Thr Trp Gly Lys Lys Ile Asp 
    50                  55                  60                  


Phe Leu Leu Ser Val Val Gly Phe Ala Val Asp Leu Ala Asn Val Trp 
65                  70                  75                  80  


Arg Phe Pro Tyr Leu Cys Tyr Lys Asn Gly Gly Gly Ala Phe Leu Ile 
                85                  90                  95      


Pro Tyr Thr Leu Phe Leu Ile Ile Ala Gly Met Pro Leu Phe Tyr Met 
            100                 105                 110         


Glu Leu Ala Leu Gly Gln Tyr Asn Arg Glu Gly Ala Ala Thr Val Trp 
        115                 120                 125             


Lys Ile Cys Pro Phe Phe Lys Gly Val Gly Tyr Ala Val Ile Leu Ile 
    130                 135                 140                 


Ala Leu Tyr Val Gly Phe Tyr Tyr Asn Val Ile Ile Ala Trp Ser Leu 
145                 150                 155                 160 


Tyr Tyr Leu Phe Ser Ser Phe Thr Leu Asn Leu Pro Trp Thr Asp Cys 
                165                 170                 175     


Gly His Thr Trp Asn Ser Pro Asn Cys Thr Asp Pro Lys Leu Leu Asn 
            180                 185                 190         


Gly Ser Val Leu Gly Asn His Thr Lys Tyr Ser Lys Tyr Lys Phe Thr 
        195                 200                 205             


Pro Ala Ala Glu Phe Tyr Glu Arg Gly Val Leu His Leu His Glu Ser 
    210                 215                 220                 


Ser Gly Ile His Asp Ile Gly Leu Pro Gln Trp Gln Leu Leu Leu Cys 
225                 230                 235                 240 


Leu Met Val Val Val Ile Val Leu Tyr Phe Ser Leu Trp Lys Gly Val 
                245                 250                 255     


Lys Thr Ser Gly Lys Val Val Trp Ile Thr Ala Thr Leu Pro Tyr Phe 
            260                 265                 270         


Val Leu Phe Val Leu Leu Val His Gly Val Thr Leu Pro Gly Ala Ser 
        275                 280                 285             


Asn Gly Ile Asn Ala Tyr Leu His Ile Asp Phe Tyr Arg Leu Lys Glu 
    290                 295                 300                 


Ala Thr Val Trp Ile Asp Ala Ala Thr Gln Ile Phe Phe Ser Leu Gly 
305                 310                 315                 320 


Ala Gly Phe Gly Val Leu Ile Ala Phe Ala Ser Tyr Asn Lys Phe Asp 
                325                 330                 335     


Asn Asn Cys Tyr Arg Asp Ala Leu Leu Thr Ser Ser Ile Asn Cys Ile 
            340                 345                 350         


Thr Ser Phe Val Ser Gly Phe Ala Ile Phe Ser Ile Leu Gly Tyr Met 
        355                 360                 365             


Ala His Glu His Lys Val Asn Ile Glu Asp Val Ala Thr Glu Gly Ala 
    370                 375                 380                 


Gly Leu Val Phe Ile Leu Tyr Pro Glu Ala Ile Ser Thr Leu Ser Gly 
385                 390                 395                 400 


Ser Thr Phe Trp Ala Val Val Phe Phe Val Met Leu Leu Ala Leu Gly 
                405                 410                 415     


Leu Asp Ser Ser Met Gly Gly Met Glu Ala Val Ile Thr Gly Leu Ala 
            420                 425                 430         


Asp Asp Phe Gln Val Leu Lys Arg His Arg Lys Leu Phe Thr Phe Gly 
        435                 440                 445             


Val Thr Phe Ser Thr Phe Leu Leu Ala Leu Phe Cys Ile Thr Lys Gly 
    450                 455                 460                 


Gly Ile Tyr Val Leu Thr Leu Leu Asp Thr Phe Ala Ala Gly Thr Ser 
465                 470                 475                 480 


Ile Leu Phe Ala Val Leu Met Glu Ala Ile Gly Val Ser Trp Phe Tyr 
                485                 490                 495     


Gly Val Asp Arg Phe Ser Asn Asp Ile Gln Gln Met Met Gly Phe Arg 
            500                 505                 510         


Pro Gly Leu Tyr Trp Arg Leu Cys Trp Lys Phe Val Ser Pro Ala Phe 
        515                 520                 525             


Leu Leu Phe Val Val Val Val Ser Ile Ile Asn Phe Lys Pro Leu Thr 
    530                 535                 540                 


Tyr Asp Asp Tyr Ile Phe Pro Pro Trp Ala Asn Trp Val Gly Trp Gly 
545                 550                 555                 560 


Ile Ala Leu Ser Ser Met Val Leu Val Pro Ile Tyr Val Ile Tyr Lys 
                565                 570                 575     


Phe Leu Ser Thr Gln Gly Ser Leu Trp Glu Arg Leu Ala Tyr Gly Ile 
            580                 585                 590         


Thr Pro Glu Asn Glu His His Leu Val Ala Gln Arg Asp Ile Arg Gln 
        595                 600                 605             


Phe Gln Leu Gln His Trp Leu Ala Ile 
    610                 615         


<210>  9
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA sense primer for OCT1 nucleic acid

<400>  9
ctgtgtagac cccctggcta                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA antisense primer for OCT1 nucleic acid

<400>  10
gtgtagccag ccatccagtt                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA sense primer for OCT2 nucleic acid

<400>  11
cctggtatgt gccaactcct                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA antisense primer for OCT2 nucleic acid

<400>  12
caccaggagc ccaactgtat                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA sense primer for OCT3 nucleic acid

<400>  13
atcgtcagcg agtttgacct                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA antisense primer for OCT3 nucleic acid

<400>  14
ttgaatcacg attcccacaa                                                   20


