                         SEQUENCE LISTING

<110>  Yissum Research Development Company of the Hebrew 
       University of Jerusalem Ltd.
 
<120>  PROGNOSTIC METHODS AND COMPOSITIONS FOR PREDICTING INTERFERON 
       TREATMENT EFICACY IN A SUBJECT

<130>  2173223

<150>  US 61/530,975
<151>  2011-09-04

<160>  121   

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  1
ugagaacuga auuccauggg uu                                                22


<210>  2
<211>  99
<212>  RNA
<213>  Homo sapiens

<400>  2
ccgaugugua uccucagcuu ugagaacuga auuccauggg uugugucagu gucagaccuc       60

ugaaauucag uucuucagcu gggauaucuc ugucaucgu                              99


<210>  3
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  3
tgagaactga attccatggg tt                                                22


<210>  4
<211>  99
<212>  DNA
<213>  Homo sapiens

<400>  4
ccgatgtgta tcctcagctt tgagaactga attccatggg ttgtgtcagt gtcagacctc       60

tgaaattcag ttcttcagct gggatatctc tgtcatcgt                              99


<210>  5
<211>  2329
<212>  DNA
<213>  Homo sapiens

<400>  5
gaaagatgct ctttctccaa gacgcttgac cgctcttcct ttcctggatg gcaccagcag       60

ggccgattgg agtggtaaac cctgggccgg aaggcatgcc aaagggtgga caggatggac      120

aggagacagt agcacaacga ggagggggag aacagcggct gaattggaaa tgataaaata      180

aaatgaaatt ttaggagctc gctggctggg acaggcctgg actgcaagga ggggtctttg      240

caccatctct gaaaagccga tgtgtatcct cagctttgag aactgaattc catgggttgt      300

gtcagtgtca gacctctgaa attcagttct tcagctggga tatctctgtc atcgtgggct      360

tgaggacctg gagagagtag atcctgaaga actttttcag tctgctgaag agcttggaag      420

actggagaca gaaggcagag tctcaggctc tgaaggtata aggagtgtga gttcctgtga      480

gaaacactca tttgattgtg aaaagacttg aattctatgc taagcagggt tccaagtagc      540

taaatgaatg atctcagcaa gtctctcttg ctgctgctgc tactcgttta catttattga      600

ttacttacga tgattcaggt actgttgtaa gtgctttaca tgctgttata cgagactctt      660

gggagaaatc actttaatga agcttgagac acatggcatt gccatgcaat gatttttccc      720

ccctcttcac gggatcagag ggaactaata gaatgtgaca atgattcttt agcagggact      780

gctgaggctt ctggttcctt tttaagatct gcagtgaaag aagatgagaa acatggatat      840

gcccttcttt tggtccccct cttcctttat ttgatctcta cttccttcta taaatatatt      900

agggctacat tgtccctttg tatttcaaac aaggcaaaaa gaggttgtaa ttacacttta      960

ctgcaatcct cagtttctcc agggaacagg aatgcaaagg ctttgaaggc ctctctattt     1020

gctgacatgg tcagctgggt gccatgggcc aagtccttct gttgccctcc tctgtcacca     1080

agtaagctag gtcctttctg aggctcaggt ttgctgtgat gatgatcact tttaggcaga     1140

aggttagagg cctcatgagt gctatatgga ctttattagg ctttagattt gatggggaat     1200

aagggatgtg atttgtcttt tgggaactca tctttgattc atcattgtct cttggtatct     1260

tggaatttcc atgtcattac agtctacaga atgaaagagt aacctgtccc agaggagagg     1320

caggtgaaag actccacagc atgctcattc tcattctgtc ttctcagtga caccgaggtt     1380

tactgagtgc ccactatgtg ccaagcactg tgctcagggc tttctttgta tgcatgatct     1440

cagtgaatct caccaagcct catctggaaa acggggacaa attaacaaca ggatggcaaa     1500

ttgaaaaaca cgtaaccatg ttctacagat ggaaaggggt gcttggttat tatgaaggcc     1560

ccctcgcaag cgtgtgggac atgggtgtgt tctctgggtt gtactgatca gatcaaggac     1620

ctcccccacc cttctcacac tctgcccact tccgcccttt gcttatcaga cccttagcca     1680

gtgactcatt ccagaaccag aaccttggtg aaatctcaac cgacaccaga gatcggtgtc     1740

ttcagtccta gactgatgga gaaaatccag aatatatact agaagctcca aatgctctgg     1800

gtttcagctc ctctgtgctg tggacactga ctttggctca gaactccgat ttagtacaaa     1860

aggctcattt ttatttcagg ggcactcttc ctaaagcaaa cctaataaat gaaatatgga     1920

attcacagat acacacacac attaaaaaat taacctagtg tatctgtgag gagtaggcag     1980

aaattcactg tataaaagaa tgcttcattt catagagaat ttgtgttaag attccattag     2040

atagtacatt tctcaaagat ttttgaggtt gtatttgctt taccaaaact tggtttatgt     2100

aagtggaaaa agcatgttgc aaaataactt ggtgtctatg attcagttta tgtaaaataa     2160

taaatgtatg taggaatacg tgtgttgaaa gatgtacatc aatttgctaa caatggttat     2220

ctctgacgtg gtgggatttg agatgtgttt ttctttttgg ttgtattttt ctctattgtt     2280

tgacttaaca cagaacatgt ttggttacaa caataaagtt attgaagac                 2329


<210>  6
<211>  2337
<212>  DNA
<213>  Homo sapiens

<400>  6
tctccaagac gcttgaccgc tcttcctttc ctggatggca ccagcagggc cgattggagt       60

ggtaaaccct gggccggaag gcatgccaaa gggtggacag gatggacagg agacagtagc      120

acaacgagga gggggagaac agtggctgaa ttggaaatga taaaataaaa tgaaatttta      180

ggagctcgct ggctgggaca ggcctggact gcaaggaggg gtctttgcac catctctgaa      240

aagccgatgt gtatcctcag ctttgagaac tgaattccat gggttgtgtc agtgtcagac      300

ctgtgaaatt cagttcttca gctgggatat ctctgtcatc gtgggcttga ggacctggag      360

agagtagatc ctgaagaact ttttcagtct gctgaagagc ttggaagact ggagacagaa      420

ggcagagtct caggctctga aggtataagg agtgtgagtt cctgtgagaa acactcattt      480

gattgtgaaa agacttgaat tctatgctaa gcagggttcc aagtagctaa atgaatgatc      540

tcagcaagtc tctcttgctg ctgctgctac tcgtttacat ttattgatta cttacgatga      600

ttcaggtact gttgtaagtg ctttacatgc tgttatacga gactcttggg agaaatcact      660

ttaatgaagc ttgagacaca tggcattgcc atgcaatgat ttttcccccc tcttcacggg      720

atcagaggga actaatagaa tgtgacaatg attctttagc agggactgct gaggcttctg      780

gttccttttt aagatctgca gtgaaagaag atgagaaaca tggatatgcc cttcttttgg      840

tccccctctt cctttatttg atctctactt ccttctataa atatattagg gctacattgt      900

ccctttgtat ttcaaacaag gcaaaaagag gttgtaatta cactttactg caatcctcag      960

tttctccagg gaacaggaat gcaaaggctt tgaaggcctc tctatttgct gacatggtca     1020

gctgggtgcc atgggccaag tccttctgtt gccctcctct gtcaccaagt aagctaggtc     1080

ctttctgagg ctcaggtttg ctgtgatgat gatcactttt aggcagaagg ttagaggcct     1140

catgagtgct atatggactt tattaggctt tagatttgat ggggaataag ggatgtgatt     1200

tgtcttttgg gaactcatct ttgattcatc attgtctctt ggtatcttgg aatttccatg     1260

tcattacagt ctacagaatg aaagagtaac ctgtcccaga ggagaggcag gtgaaagact     1320

ccacagcatg ctcattctca ttctgtcttc tcagtgacac cgaggtttac tgagtgccca     1380

ctatgtgcca agcactgtgc tcagggcttt ctttgtatgc atgatctcag tgaatctcac     1440

caagcctcat ctggaaaacg gggacaaatt aacaacagga tggcaaattg aaaaacacgt     1500

aaccatgttc tacagatgga aaggggtgct tggttattat gaaggccccc tcgcaagcgt     1560

gtgggacatg ggtgtgttct ctgggttgta ctgatcagat caaggacctc ccccaccctt     1620

ctcacactct gcccacttcc gccctttgct tatcagaccc ttagccagtg actcattcca     1680

gaaccagaac cttggtgaaa tctcaaccga caccagagat cggtgtcttc agtcctagac     1740

tgatggagaa aatccagaat atatactaga agctccaaat gctctgggtt tcagctcctc     1800

tgtgctgtgg acactgactt tggctcagaa ctccgattta gtacaaaagg ctcattttta     1860

tttcaggggc actcttccta aagcaaacct aataaatgaa atatggaatt cacagataca     1920

cacacacatt aaaaaattaa cctagtgtat ctgtgaggag taggcagaaa ttcactgtat     1980

aaaagaatgc ttcatttcat agagaatttg tgttaagatt ccattagata gtacatttct     2040

caaagatttt tgaggttgta tttgctttac caaaacttgg tttatgtaag tggaaaaagc     2100

atgttgcaaa ataacttggt gtctatgatt cagtttatgt aaaataataa atgtatgtag     2160

gaatacgtgt gttgaaagat gtacatcaat ttgctaacaa tggttatctc tgacgtggtg     2220

ggatttgaga tgtgtttttc tttttggttg tatttttctc tattgtttga cttaacacag     2280

aacatgcttg gttacaacaa taaagttatt gaagacaaaa aaaaaaaaaa aaaaaaa        2337


<210>  7
<211>  863
<212>  DNA
<213>  Homo sapiens

<400>  7
caaggttcag agtcacccat ctcagcaagc ccagaagtat ctgcaatatc tacgatggcc       60

tcgccctttg ctttactgat ggtcctggtg gtgctcagct gcaagtcaag ctgctctctg      120

ggctgtgatc tccctgagac ccacagcctg gataacagga ggaccttgat gctcctggca      180

caaatgagca gaatctctcc ttcctcctgt ctgatggaca gacatgactt tggatttccc      240

caggaggagt ttgatggcaa ccagttccag aaggctccag ccatctctgt cctccatgag      300

ctgatccagc agatcttcaa cctctttacc acaaaagatt catctgctgc ttgggatgag      360

gacctcctag acaaattctg caccgaactc taccagcagc tgaatgactt ggaagcctgt      420

gtgatgcagg aggagagggt gggagaaact cccctgatga atgcggactc catcttggct      480

gtgaagaaat acttccgaag aatcactctc tatctgacag agaagaaata cagcccttgt      540

gcctgggagg ttgtcagagc agaaatcatg agatccctct ctttatcaac aaacttgcaa      600

gaaagattaa ggaggaagga ataacatctg gtccaacatg aaaacaattc ttattgactc      660

atacaccagg tcacgctttc atgaattctg tcatttcaaa gactctcacc cctgctataa      720

ctatgaccat gctgataaac tgatttatct atttaaatat ttatttaact attcataaga      780

tttaaattat ttttgttcat ataacgtcat gtgcaccttt acactgtggt tagtgtaata      840

aaacatgttc cttatattta ctc                                              863


<210>  8
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Ser Pro Phe Ala Leu Leu Met Val Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Gly Cys Asp Leu Pro Glu Thr His Ser Leu 
            20                  25                  30          


Asp Asn Arg Arg Thr Leu Met Leu Leu Ala Gln Met Ser Arg Ile Ser 
        35                  40                  45              


Pro Ser Ser Cys Leu Met Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Pro Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Leu Ile Gln Gln Ile Phe Asn Leu Phe Thr Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Asp Leu Leu Asp Lys Phe Cys Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Glu Arg 
        115                 120                 125             


Val Gly Glu Thr Pro Leu Met Asn Ala Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Arg Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Leu Ser Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  9
<211>  1143
<212>  DNA
<213>  Homo sapiens

<400>  9
gagaacctgg agcctaaggt ttaggctcac ccatttcaac cagtctagca gcatctgcaa       60

catctacaat ggccttgacc tttgctttac tggtggccct cctggtgctc agctgcaagt      120

caagctgctc tgtgggctgt gatctgcctc aaacccacag cctgggtagc aggaggacct      180

tgatgctcct ggcacagatg aggagaatct ctcttttctc ctgcttgaag gacagacatg      240

actttggatt tccccaggag gagtttggca accagttcca aaaggctgaa accatccctg      300

tcctccatga gatgatccag cagatcttca atctcttcag cacaaaggac tcatctgctg      360

cttgggatga gaccctccta gacaaattct acactgaact ctaccagcag ctgaatgacc      420

tggaagcctg tgtgatacag ggggtggggg tgacagagac tcccctgatg aaggaggact      480

ccattctggc tgtgaggaaa tacttccaaa gaatcactct ctatctgaaa gagaagaaat      540

acagcccttg tgcctgggag gttgtcagag cagaaatcat gagatctttt tctttgtcaa      600

caaacttgca agaaagttta agaagtaagg aatgaaaact ggttcaacat ggaaatgatt      660

ttcattgatt cgtatgccag ctcacctttt tatgatctgc catttcaaag actcatgttt      720

ctgctatgac catgacacga tttaaatctt ttcaaatgtt tttaggagta ttaatcaaca      780

ttgtattcag ctcttaaggc actagtccct tacagaggac catgctgact gatccattat      840

ctatttaaat atttttaaaa tattatttat ttaactattt ataaaacaac ttatttttgt      900

tcatattatg tcatgtgcac ctttgcacag tggttaatgt aataaaatat gttctttgta      960

tttggtaaat ttattttgtg ttgttcattg aacttttgct atggaaactt ttgtacttgt     1020

ttattcttta aaatgaaatt ccaagcctaa ttgtgcaacc tgattacaga ataactggta     1080

cacttcattt atccatcaat attatattca agatataagt aaaaataaac tttctgtaaa     1140

cca                                                                   1143


<210>  10
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Ser Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu His 
65                  70                  75                  80  


Glu Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser 
                85                  90                  95      


Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr 
            100                 105                 110         


Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val Gly Val 
        115                 120                 125             


Thr Glu Thr Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val Arg Lys 
    130                 135                 140                 


Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro 
145                 150                 155                 160 


Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser Leu 
                165                 170                 175     


Ser Thr Asn Leu Gln Glu Ser Leu Arg Ser Lys Glu 
            180                 185             


<210>  11
<211>  982
<212>  DNA
<213>  Homo sapiens

<400>  11
agaaaaccta gaggccgaag ttcaaggtta tccatctcaa gtagcctagc aatatttgca       60

acatcccaat ggccctgtcc ttttctttac tgatggccgt gctggtgctc agctacaaat      120

ccatctgttc tctgggctgt gatctgcctc agacccacag cctgggtaat aggagggcct      180

tgatactcct ggcacaaatg ggaagaatct ctcatttctc ctgcctgaag gacagacatg      240

atttcggatt ccccgaggag gagtttgatg gccaccagtt ccagaaggct caagccatct      300

ctgtcctcca tgagatgatc cagcagacct tcaatctctt cagcacagag gactcatctg      360

ctgcttggga acagagcctc ctagaaaaat tttccactga actttaccag caactgaatg      420

acctggaagc atgtgtgata caggaggttg gggtggaaga gactcccctg atgaatgagg      480

actccatcct ggctgtgagg aaatacttcc aaagaatcac tctttatcta acagagaaga      540

aatacagccc ttgtgcctgg gaggttgtca gagcagaaat catgagatcc ctctcgtttt      600

caacaaactt gcaaaaaaga ttaaggagga aggattgaaa cctggttcaa catggaaatg      660

atcctgattg actaatacat tatctcacac tttcatgagt tcttccattt caaagactca      720

cttctataac caccacgagt tgaatcaaaa ttttcaaatg ttttcagcag tgtgaagaag      780

cttggtgtat acctgtgcag gcactagtcc tttacagatg acaatgctga tgtctctgtt      840

catctattta tttaaatatt tatttatttt taaaatttaa attatttttt atgtgatatc      900

atgagtacct ttacattgtg gtgaatgtaa caatatatgt tcttcatatt tagccaatat      960

attaatttcc tttttcatta aa                                               982


<210>  12
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


His Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Glu Glu 
    50                  55                  60                  


Glu Phe Asp Gly His Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Arg Leu Arg Arg Lys Asp 
            180                 185                 


<210>  13
<211>  700
<212>  DNA
<213>  Homo sapiens

<400>  13
gcccaaggtt cagggtcact caatctcaac agcccagaag catctgcaac ctccccaatg       60

gccttgccct ttgttttact gatggccctg gtggtgctca actgcaagtc aatctgttct      120

ctgggctgtg atctgcctca gacccacagc ctgagtaaca ggaggacttt gatgataatg      180

gcacaaatgg gaagaatctc tcctttctcc tgcctgaagg acagacatga ctttggattt      240

cctcaggagg agtttgatgg caaccagttc cagaaggctc aagccatctc tgtcctccat      300

gagatgatcc agcagacctt caatctcttc agcacaaagg actcatctgc tacttgggat      360

gagacacttc tagacaaatt ctacactgaa ctttaccagc agctgaatga cctggaagcc      420

tgtatgatgc aggaggttgg agtggaagac actcctctga tgaatgtgga ctctatcctg      480

actgtgagaa aatactttca aagaatcacc ctctatctga cagagaagaa atacagccct      540

tgtgcatggg aggttgtcag agcagaaatc atgagatcct tctctttatc agcaaacttg      600

caagaaagat taaggaggaa ggaatgaaaa ctggttcaac atcgaaatga ttctcattga      660

ctagtacacc atttcacact tcttgagttc tgccgtttca                            700


<210>  14
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Leu Pro Phe Val Leu Leu Met Ala Leu Val Val Leu Asn Cys 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Ser Asn Arg Arg Thr Leu Met Ile Met Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Thr Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Met Met Gln Glu Val Gly 
        115                 120                 125             


Val Glu Asp Thr Pro Leu Met Asn Val Asp Ser Ile Leu Thr Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Leu Ser Ala Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  15
<211>  570
<212>  DNA
<213>  Homo sapiens

<400>  15
atggctttgc cttttgcttt actgatggcc ctggtggtgc tcagctgcaa gtcaagctgc       60

tctctggact gtgatctgcc tcagacccac agcctgggtc acaggaggac catgatgctc      120

ctggcacaaa tgaggagaat ctctcttttc tcctgtctga aggacagaca tgacttcaga      180

tttccccagg aggagtttga tggcaaccag ttccagaagg ctgaagccat ctctgtcctc      240

catgaggtga ttcagcagac cttcaacctc ttcagcacaa aggactcatc tgttgcttgg      300

gatgagaggc ttctagacaa actctatact gaactttacc agcagctgaa tgacctggaa      360

gcctgtgtga tgcaggaggt gtgggtggga gggactcccc tgatgaatga ggactccatc      420

ctggctgtga gaaaatactt ccaaagaatc actctctacc tgacagagaa aaagtacagc      480

ccttgtgcct gggaggttgt cagagcagaa atcatgagat ccttctcttc atcaagaaac      540

ttgcaagaaa ggttaaggag gaaggaataa                                       570


<210>  16
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Leu Pro Phe Ala Leu Leu Met Ala Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Asp Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly His Arg Arg Thr Met Met Leu Leu Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Arg Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Glu Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Val Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Val Ala Trp Asp Glu Arg Leu Leu Asp Lys Leu Tyr Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Val Trp 
        115                 120                 125             


Val Gly Gly Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Ser Ser Arg Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  17
<211>  736
<212>  DNA
<213>  Homo sapiens

<400>  17
tacccacctc aggtagccta gtgatatttg caaaatccca atggcccggt ccttttcttt       60

actgatggtc gtgctggtac tcagctacaa atccatctgc tctctgggct gtgatctgcc      120

tcagacccac agcctgcgta ataggagggc cttgatactc ctggcacaaa tgggaagaat      180

ctctcctttc tcctgcttga aggacagaca tgaattcaga ttcccagagg aggagtttga      240

tggccaccag ttccagaaga ctcaagccat ctctgtcctc catgagatga tccagcagac      300

cttcaatctc ttcagcacag aggactcatc tgctgcttgg gaacagagcc tcctagaaaa      360

attttccact gaactttacc agcaactgaa tgacctggaa gcatgtgtga tacaggaggt      420

tggggtggaa gagactcccc tgatgaatga ggacttcatc ctggctgtga ggaaatactt      480

ccaaagaatc actctttatc taatggagaa gaaatacagc ccttgtgcct gggaggttgt      540

cagagcagaa atcatgagat ccttctcttt ttcaacaaac ttgaaaaaag gattaaggag      600

gaaggattga aaactggttc atcatggaaa tgattctcat tgactaatgc atcatctcac      660

actttcatga gttcttccat ttcaaagact cacttctata accaccacaa gttaatcaaa      720

atttccaaat gttttc                                                      736


<210>  18
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Arg Ser Phe Ser Leu Leu Met Val Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Arg Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Glu Phe Arg Phe Pro Glu Glu 
    50                  55                  60                  


Glu Phe Asp Gly His Gln Phe Gln Lys Thr Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Glu Asp Phe Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Met Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Lys Lys Gly Leu Arg Arg Lys Asp 
            180                 185                 


<210>  19
<211>  1039
<212>  DNA
<213>  Homo sapiens

<400>  19
accagctcag cagcatccac aacatctaca atggccttga ctttttattt actggtggcc       60

ctagtggtgc tcagctacaa gtcattcagc tctctgggct gtgatctgcc tcagactcac      120

agcctgggta acaggagggc cttgatactc ctggcacaaa tgcgaagaat ctctcctttc      180

tcctgcctga aggacagaca tgactttgaa ttcccccagg aggagtttga tgataaacag      240

ttccagaagg ctcaagccat ctctgtcctc catgagatga tccagcagac cttcaacctc      300

ttcagcacaa aggactcatc tgctgctttg gatgagaccc ttctagatga attctacatc      360

gaacttgacc agcagctgaa tgacctggag tcctgtgtga tgcaggaagt gggggtgata      420

gagtctcccc tgatgtacga ggactccatc ctggctgtga ggaaatactt ccaaagaatc      480

actctatatc tgacagagaa gaaatacagc tcttgtgcct gggaggttgt cagagcagaa      540

atcatgagat ccttctcttt atcaatcaac ttgcaaaaaa gattgaagag taaggaatga      600

gacctggtac aacacggaaa tgattcttat agactaatac agcagctcac acttcgacaa      660

gttgtgctct ttcaaagacc cttgtttctg ccaaaaccat gctatgaatt gaatcaaatg      720

tgtcaagtgt tttcaggagt gttaagcaac atcctgttca gctgtatggg cactagtccc      780

ttacagatga ccatgctgat ggatctattc atctatttat ttaaatcttt atttagttaa      840

ctatctatag ggcttaaatt agttttgttc atattatatt atgtgaactt ttacattgtg      900

aattgtgtaa caaaaacatg ttctttatat ttattatttt gccttgttta ttaaattttt      960

actatagaaa aattctttat ttattcttta aaattgaact ccaaccctga ttgtgcaaac     1020

tgattaaaga atggatggt                                                  1039


<210>  20
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Leu Thr Phe Tyr Leu Leu Val Ala Leu Val Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Phe Ser Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Glu Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Asp Lys Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Leu Asp Glu Thr Leu Leu Asp Glu Phe Tyr Ile Glu Leu 
            100                 105                 110         


Asp Gln Gln Leu Asn Asp Leu Glu Ser Cys Val Met Gln Glu Val Gly 
        115                 120                 125             


Val Ile Glu Ser Pro Leu Met Tyr Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Ser Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Leu Ser Ile Asn Leu Gln Lys Arg Leu Lys Ser Lys Glu 
            180                 185                 


<210>  21
<211>  963
<212>  DNA
<213>  Homo sapiens

<400>  21
caaggttatc catctcaagt agcctagcaa tatttgcaac atcccaatgg ccctgtcctt       60

ttctttactt atggccgtgc tggtgctcag ctacaaatcc atctgttctc tgggctgtga      120

tctgcctcag acccacagcc tcggtaatag gagggccttg atactcctgg gacaaatggg      180

aagaatctct cctttctcct gcctgaagga cagacatgat ttccgaatcc cccaggagga      240

gtttgatggc aaccagttcc agaaggctca agccatctct gtcctccatg agatgatcca      300

gcagaccttc aatctcttca gcacagagga ctcatctgct gcttgggaac agagcctcct      360

agaaaaattt tccactgaac tttaccagca actgaatgac ctggaagcat gtgtgataca      420

ggaggttggg gtggaagaga ctcccctgat gaatgaggac tccatcctgg ctgtgaggaa      480

atacttccaa agaatcactc tttatctaat agagaggaaa tacagccctt gtgcctggga      540

ggttgtcaga gcagaaatca tgagatccct ctcgttttca acaaacttgc aaaaaagatt      600

aaggaggaag gattgaaaac tggttcaaca tggcaatgat cctgattgac taatacatta      660

tctcacactt tcatgagttc ttccatttca aagactcact tctataacca cgacgcgttg      720

aatcaaaatt ttcaaatgtt ttcagcagtg taaagaagtg tcgtgtatac ctgtgcaggc      780

actagtcctt tacagatgac cattctgatg tctctgttca tcttttgttt aaatatttat      840

ttaattattt ttaaaattta tgtaatatca tgagtcgctt tacattgtgg ttaatgtaac      900

aatatatgtt cttcatattt agccaatata ttaatttcct ttttcattaa atttttacta      960

tac                                                                    963


<210>  22
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Gly Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Arg Ile Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Ile Glu Arg Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Arg Leu Arg Arg Lys Asp 
            180                 185                 


<210>  23
<211>  705
<212>  DNA
<213>  Homo sapiens

<400>  23
agagaaccta gagcccaagg ttcagagtca cccatctcag caagcccaga agcatctgca       60

atatctatga tggcctcgcc ctttgcttta ctgatggccc tggtggtgct cagctgcaag      120

tcaagctgct ctctgggctg tgatctccct gagacccaca gcctggataa caggaggacc      180

ttgatgctcc tggcacaaat gagcagaatc tctccttcct cctgtctgat ggacagacat      240

gactttggat ttccccagga ggagtttgat ggcaaccagt tccagaaggc tccagccatc      300

tctgtcctcc atgagctgat ccagcagatc ttcaacctct ttaccacaaa agattcatct      360

gctgcttggg atgaggacct cctagacaaa ttctgcaccg aactctacca gcagctgaat      420

gacttggaag cctgtgtgat gcaggaggag agggtgggag aaactcccct gatgaatgcg      480

gactccatct tggctgtgaa gaaatacttc cgaagaatca ctctctatct gacagagaag      540

aaatacagcc cttgtgcctg ggaggttgtc agagcagaaa tcatgagatc cctctcttta      600

tcaacaaact tgcaagaaag attaaggagg aaggaataac acctggtcca acatgaaaca      660

attcttattg actcatatac caggtcacgc tttcatgaat tctgc                      705


<210>  24
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Met Ala Ser Pro Phe Ala Leu Leu Met Ala Leu Val Val Leu Ser 
1               5                   10                  15      


Cys Lys Ser Ser Cys Ser Leu Gly Cys Asp Leu Pro Glu Thr His Ser 
            20                  25                  30          


Leu Asp Asn Arg Arg Thr Leu Met Leu Leu Ala Gln Met Ser Arg Ile 
        35                  40                  45              


Ser Pro Ser Ser Cys Leu Met Asp Arg His Asp Phe Gly Phe Pro Gln 
    50                  55                  60                  


Glu Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Pro Ala Ile Ser Val 
65                  70                  75                  80  


Leu His Glu Leu Ile Gln Gln Ile Phe Asn Leu Phe Thr Thr Lys Asp 
                85                  90                  95      


Ser Ser Ala Ala Trp Asp Glu Asp Leu Leu Asp Lys Phe Cys Thr Glu 
            100                 105                 110         


Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Glu 
        115                 120                 125             


Arg Val Gly Glu Thr Pro Leu Met Asn Ala Asp Ser Ile Leu Ala Val 
    130                 135                 140                 


Lys Lys Tyr Phe Arg Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr 
145                 150                 155                 160 


Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu 
                165                 170                 175     


Ser Leu Ser Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 190 


<210>  25
<211>  778
<212>  DNA
<213>  Homo sapiens

<400>  25
gttacccctc atcaaccagc ccagcagcat cttcgggatt cccaatggca ttgccctttg       60

ctttaatgat ggccctggtg gtgctcagct gcaagtcaag ctgctctctg ggctgtaatc      120

tgtctcaaac ccacagcctg aataacagga ggactttgat gctcatggca caaatgagga      180

gaatctctcc tttctcctgc ctgaaggaca gacatgactt tgaatttccc caggaggaat      240

ttgatggcaa ccagttccag aaagctcaag ccatctctgt cctccatgag atgatgcagc      300

agaccttcaa tctcttcagc acaaagaact catctgctgc ttgggatgag accctcctag      360

aaaaattcta cattgaactt ttccagcaaa tgaatgacct ggaagcctgt gtgatacagg      420

aggttggggt ggaagagact cccctgatga atgaggactc catcctggct gtgaagaaat      480

acttccaaag aatcactctt tatctgatgg agaagaaata cagcccttgt gcctgggagg      540

ttgtcagagc agaaatcatg agatccctct ctttttcaac aaacttgcaa aaaagattaa      600

ggaggaagga ttgaaaactg gttcatcatg gaaatgattc tcattgacta atacatcatc      660

tcacactttc atgagttctt ccatttcaaa gactcacttc tcctataacc accacaagtt      720

gaatcaaaat tttcaaatgt tttcaggagt gtaaagaagc atcatgtata cctgtgca        778


<210>  26
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Leu Pro Phe Ala Leu Met Met Ala Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Gly Cys Asn Leu Ser Gln Thr His Ser Leu 
            20                  25                  30          


Asn Asn Arg Arg Thr Leu Met Leu Met Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Glu Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Met Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asn Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Thr Leu Leu Glu Lys Phe Tyr Ile Glu Leu 
            100                 105                 110         


Phe Gln Gln Met Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Met Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Arg Leu Arg Arg Lys Asp 
            180                 185                 


<210>  27
<211>  939
<212>  DNA
<213>  Homo sapiens

<400>  27
atcccaatgg ccctgtcctt ttctttactg atggccgtgc tggtgctcag ctacaaatcc       60

atctgttctc tgggctgtga tctgcctcag actcacagcc tgggtaatag gagggccttg      120

atactcctgg cacaaatggg aagaatctct catttctcct gcctgaagga cagatatgat      180

ttcggattcc cccaggaggt gtttgatggc aaccagttcc agaaggctca agccatctct      240

gccttccatg agatgatcca gcagaccttc aatctcttca gcacaaagga ttcatctgct      300

gcttgggatg agaccctcct agacaaattc tacattgaac ttttccagca actgaatgac      360

ctagaagcct gtgtgacaca ggaggttggg gtggaagaga ttgccctgat gaatgaggac      420

tccatcctgg ctgtgaggaa atactttcaa agaatcactc tttatctgat ggggaagaaa      480

tacagccctt gtgcctggga ggttgtcaga gcagaaatca tgagatcctt ctctttttca      540

acaaacttgc aaaaaggatt aagaaggaag gattgaaaac tcattcaaca tggaaatgat      600

cctcattgat taatacatca tctcacactt tcatgagttc ttccatttca aagactcact      660

tctataacca ccacaagttg aatcaaaatt tcaaaatgtt ttcaggagtg taaagaagca      720

tcgtgtttac ctgtgcaggc actagtcctt tacagatgac catgctgatg tctctattca      780

tctatttatt taaatattta tttatttaac tatttttaag gtttaaatca tgttttatgt      840

aatatcatgt gtacctttac attttgctta atgtaacaat atatgttctt catatttagt      900

taatatatta acttcctttt cattaaattt ttactatac                             939


<210>  28
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


His Phe Ser Cys Leu Lys Asp Arg Tyr Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Val Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Ala Phe 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Ile Glu Leu 
            100                 105                 110         


Phe Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Thr Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Ile Ala Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Met Gly Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Gly Leu Arg Arg Lys Asp 
            180                 185                 


<210>  29
<211>  980
<212>  DNA
<213>  Homo sapiens

<400>  29
gttcaaggtt acccatctca agtagcctag caacatttgc aacatcccaa tggccctgtc       60

cttttcttta ctgatggccg tgctggtgct cagctacaaa tccatctgtt ctctaggctg      120

tgatctgcct cagacccaca gcctgggtaa taggagggcc ttgatactcc tggcacaaat      180

gggaagaatc tctcctttct cctgcctgaa ggacagacat gactttggac ttccccagga      240

ggagtttgat ggcaaccagt tccagaagac tcaagccatc tctgtcctcc atgagatgat      300

ccagcagacc ttcaatctct tcagcacaga ggactcatct gctgcttggg aacagagcct      360

cctagaaaaa ttttccactg aactttacca gcaactgaat aacctggaag catgtgtgat      420

acaggaggtt gggatggaag agactcccct gatgaatgag gactccatcc tggctgtgag      480

gaaatacttc caaagaatca ctctttatct aacagagaag aaatacagcc cttgtgcctg      540

ggaggttgtc agagcagaaa tcatgagatc tctctctttt tcaacaaact tgcaaaaaat      600

attaaggagg aaggattgaa aactggttca acatggcaat gatcctgatt gactaataca      660

ttatctcaca ctttcatgag ttcctccatt tcaaagactc acttctataa ccaccacgag      720

ttgaatcaaa attttcaaat gttttcagca gtgtaaagaa gcgtcgtgta tacctgtgca      780

ggcactagta ctttacagat gaccatgctg atgtctctgt tcatctattt atttaaatat      840

ttatttaatt atttttaaga tttaaattat ttttttatgt aatatcatgt gtacctttac      900

attgtggtga atgtaacaat atatgttctt catatttagc caatatatta atttcctttt      960

tcattaaatt tttactatac                                                  980


<210>  30
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Leu Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Thr Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asn Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Met Glu Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Ile Leu Arg Arg Lys Asp 
            180                 185                 


<210>  31
<211>  1024
<212>  DNA
<213>  Homo sapiens

<400>  31
ttcaaggtta cccatctcaa gtagcctagc aatattggca acatcccaat ggccctgtcc       60

ttttctttac tgatggccgt gctggtgctc agctacaaat ccatctgttc tctgggctgt      120

gatctgcctc agacccacag cctgggtaat aggagggcct tgatactcct ggcacaaatg      180

ggaagaatct ctcctttctc ctgcctgaag gacagacatg actttggatt cccccaggag      240

gagtttgatg gcaaccagtt ccagaaggct caagccatct ctgtcctcca tgagatgatc      300

cagcagacct tcaatctctt cagcacaaag gactcatctg ctacttggga acagagcctc      360

ctagaaaaat tttccactga acttaaccag cagctgaatg acctggaagc ctgcgtgata      420

caggaggttg gggtggaaga gactcccctg atgaatgtgg actccatcct ggctgtgaag      480

aaatacttcc aaagaatcac tctttatctg acagagaaga aatacagccc ttgtgcctgg      540

gaggttgtca gagcagaaat catgagatcc ttctctttat caaaaatttt tcaagaaaga      600

ttaaggagga aggaatgaaa cctgtttcaa catggaaatg atctgtattg actaatacac      660

cagtccacac ttctatgact tctgccattt caaagactca tttctcctat aaccaccgca      720

tgagttgaat caaaattttc agatcttttc aggagtgtaa ggaaacatca tgtttacctg      780

tgcaggcact agtcctttac agatgaccat gctgatagat ctaattatct atctattgaa      840

atatttattt atttattaga tttaaattat ttttgtccat gtaatattat gtgtactttt      900

acattgtgtt atatcaaaat atgttattta tatttagtca atatattatt ttctttttat      960

taatttttac tattaaaact tcttatatta tttgtttatt ctttaataaa gaaataccaa     1020

gccc                                                                  1024


<210>  32
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Thr Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Asn Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Val Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Leu Ser Lys Ile Phe Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  33
<211>  840
<212>  DNA
<213>  Homo sapiens

<400>  33
acattctaac tgcaaccttt cgaagccttt gctctggcac aacaggtagt aggcgacact       60

gttcgtgttg tcaacatgac caacaagtgt ctcctccaaa ttgctctcct gttgtgcttc      120

tccactacag ctctttccat gagctacaac ttgcttggat tcctacaaag aagcagcaat      180

tttcagtgtc agaagctcct gtggcaattg aatgggaggc ttgaatactg cctcaaggac      240

aggatgaact ttgacatccc tgaggagatt aagcagctgc agcagttcca gaaggaggac      300

gccgcattga ccatctatga gatgctccag aacatctttg ctattttcag acaagattca      360

tctagcactg gctggaatga gactattgtt gagaacctcc tggctaatgt ctatcatcag      420

ataaaccatc tgaagacagt cctggaagaa aaactggaga aagaagattt caccagggga      480

aaactcatga gcagtctgca cctgaaaaga tattatggga ggattctgca ttacctgaag      540

gccaaggagt acagtcactg tgcctggacc atagtcagag tggaaatcct aaggaacttt      600

tacttcatta acagacttac aggttacctc cgaaactgaa gatctcctag cctgtgcctc      660

tgggactgga caattgcttc aagcattctt caaccagcag atgctgttta agtgactgat      720

ggctaatgta ctgcatatga aaggacacta gaagattttg aaatttttat taaattatga      780

gttattttta tttatttaaa ttttattttg gaaaataaat tatttttggt gcaaaagtca      840


<210>  34
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Thr Asn Lys Cys Leu Leu Gln Ile Ala Leu Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg 
            20                  25                  30          


Ser Ser Asn Phe Gln Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg 
        35                  40                  45              


Leu Glu Tyr Cys Leu Lys Asp Arg Met Asn Phe Asp Ile Pro Glu Glu 
    50                  55                  60                  


Ile Lys Gln Leu Gln Gln Phe Gln Lys Glu Asp Ala Ala Leu Thr Ile 
65                  70                  75                  80  


Tyr Glu Met Leu Gln Asn Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser 
                85                  90                  95      


Ser Thr Gly Trp Asn Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val 
            100                 105                 110         


Tyr His Gln Ile Asn His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu 
        115                 120                 125             


Lys Glu Asp Phe Thr Arg Gly Lys Leu Met Ser Ser Leu His Leu Lys 
    130                 135                 140                 


Arg Tyr Tyr Gly Arg Ile Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser 
145                 150                 155                 160 


His Cys Ala Trp Thr Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr 
                165                 170                 175     


Phe Ile Asn Arg Leu Thr Gly Tyr Leu Arg Asn 
            180                 185         


<210>  35
<211>  1514
<212>  DNA
<213>  Homo sapiens

<400>  35
gatctggtaa acctgaagca aatatagaaa cctatagggc ctgacttcct acataaagta       60

aggagggtaa aaatggaggc tagaataagg gttaaaattt tgcttctaga acagagaaaa      120

tgattttttt catatatata tgaatatata ttatatatac acatatatac atatattcac      180

tatagtgtgt atacataaat atataatata tatattgtta gtgtagtgtg tgtctgatta      240

tttacatgca tatagtatat acacttatga ctttagtacc cagacgtttt tcatttgatt      300

aagcattcat ttgtattgac acagctgaag tttactggag tttagctgaa gtctaatgca      360

aaattaatag attgttgtca tcctcttaag gtcataggga gaacacacaa atgaaaacag      420

taaaagaaac tgaaagtaca gagaaatgtt cagaaaatga aaaccatgtg tttcctatta      480

aaagccatgc atacaagcaa tgtcttcaga aaacctaggg tccaaggtta agccatatcc      540

cagctcagta aagccaggag catcctcatt tcccaatggc cctcctgttc cctctactgg      600

cagccctagt gatgaccagc tatagccctg ttggatctct gggctgtgat ctgcctcaga      660

accatggcct acttagcagg aacaccttgg tgcttctgca ccaaatgagg agaatctccc      720

ctttcttgtg tctcaaggac agaagagact tcaggttccc ccaggagatg gtaaaaggga      780

gccagttgca gaaggcccat gtcatgtctg tcctccatga gatgctgcag cagatcttca      840

gcctcttcca cacagagcgc tcctctgctg cctggaacat gaccctccta gaccaactcc      900

acactggact tcatcagcaa ctgcaacacc tggagacctg cttgctgcag gtagtgggag      960

aaggagaatc tgctggggca attagcagcc ctgcactgac cttgaggagg tacttccagg     1020

gaatccgtgt ctacctgaaa gagaagaaat acagcgactg tgcctgggaa gttgtcagaa     1080

tggaaatcat gaaatccttg ttcttatcaa caaacatgca agaaagactg agaagtaaag     1140

atagagacct gggctcatct tgaaatgatt ctcattgatt aatttgccat ataacacttg     1200

cacatgtgac tctggtcaat tcaaaagact cttatttcgg ctttaatcac agaattgact     1260

gaattagttc tgcaaatact ttgtcggtat attaagccag tatatgttaa aaagacttag     1320

gttcaggggc atcagtccct aagatgttat ttatttttac tcatttattt attcttacat     1380

tttatcatat ttatactatt tatattctta tataacaaat gtttgccttt acattgtatt     1440

aagataacaa aacatgttca gctttccatt tggttaaata ttgtattttg ttatttatta     1500

aattattttc aaac                                                       1514


<210>  36
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ala Leu Leu Phe Pro Leu Leu Ala Ala Leu Val Met Thr Ser Tyr 
1               5                   10                  15      


Ser Pro Val Gly Ser Leu Gly Cys Asp Leu Pro Gln Asn His Gly Leu 
            20                  25                  30          


Leu Ser Arg Asn Thr Leu Val Leu Leu His Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Pro Phe Leu Cys Leu Lys Asp Arg Arg Asp Phe Arg Phe Pro Gln Glu 
    50                  55                  60                  


Met Val Lys Gly Ser Gln Leu Gln Lys Ala His Val Met Ser Val Leu 
65                  70                  75                  80  


His Glu Met Leu Gln Gln Ile Phe Ser Leu Phe His Thr Glu Arg Ser 
                85                  90                  95      


Ser Ala Ala Trp Asn Met Thr Leu Leu Asp Gln Leu His Thr Gly Leu 
            100                 105                 110         


His Gln Gln Leu Gln His Leu Glu Thr Cys Leu Leu Gln Val Val Gly 
        115                 120                 125             


Glu Gly Glu Ser Ala Gly Ala Ile Ser Ser Pro Ala Leu Thr Leu Arg 
    130                 135                 140                 


Arg Tyr Phe Gln Gly Ile Arg Val Tyr Leu Lys Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Asp Cys Ala Trp Glu Val Val Arg Met Glu Ile Met Lys Ser Leu Phe 
                165                 170                 175     


Leu Ser Thr Asn Met Gln Glu Arg Leu Arg Ser Lys Asp Arg Asp Leu 
            180                 185                 190         


Gly Ser Ser 
        195 


<210>  37
<211>  1240
<212>  DNA
<213>  Homo sapiens

<400>  37
cacattgttc tgatcatctg aagatcagct attagaagag aaagatcagt taagtccttt       60

ggacctgatc agcttgatac aagaactact gatttcaact tctttggctt aattctctcg      120

gaaacgatga aatatacaag ttatatcttg gcttttcagc tctgcatcgt tttgggttct      180

cttggctgtt actgccagga cccatatgta aaagaagcag aaaaccttaa gaaatatttt      240

aatgcaggtc attcagatgt agcggataat ggaactcttt tcttaggcat tttgaagaat      300

tggaaagagg agagtgacag aaaaataatg cagagccaaa ttgtctcctt ttacttcaaa      360

ctttttaaaa actttaaaga tgaccagagc atccaaaaga gtgtggagac catcaaggaa      420

gacatgaatg tcaagttttt caatagcaac aaaaagaaac gagatgactt cgaaaagctg      480

actaattatt cggtaactga cttgaatgtc caacgcaaag caatacatga actcatccaa      540

gtgatggctg aactgtcgcc agcagctaaa acagggaagc gaaaaaggag tcagatgctg      600

tttcgaggtc gaagagcatc ccagtaatgg ttgtcctgcc tgcaatattt gaattttaaa      660

tctaaatcta tttattaata tttaacatta tttatatggg gaatatattt ttagactcat      720

caatcaaata agtatttata atagcaactt ttgtgtaatg aaaatgaata tctattaata      780

tatgtattat ttataattcc tatatcctgt gactgtctca cttaatcctt tgttttctga      840

ctaattaggc aaggctatgt gattacaagg ctttatctca ggggccaact aggcagccaa      900

cctaagcaag atcccatggg ttgtgtgttt atttcacttg atgatacaat gaacacttat      960

aagtgaagtg atactatcca gttactgccg gtttgaaaat atgcctgcaa tctgagccag     1020

tgctttaatg gcatgtcaga cagaacttga atgtgtcagg tgaccctgat gaaaacatag     1080

catctcagga gatttcatgc ctggtgcttc caaatattgt tgacaactgt gactgtaccc     1140

aaatggaaag taactcattt gttaaaatta tcaatatcta atatatatga ataaagtgta     1200

agttcacaac aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                           1240


<210>  38
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln 
                165     


<210>  39
<211>  5889
<212>  DNA
<213>  Homo sapiens

<400>  39
gctgccagct gagttttttt gctgctttga gtctcagttt tctttctttc ctagagtctc       60

tgaagccaca gatctcttaa gaactttctg tctccaaacc gtggctgctc gataaatcag      120

acagaacagt taatcctcaa tttaagcctg atctaacccc tagaaacaga tatagaacaa      180

tggaagtgac aacaagattg acatggaatg atgaaaatca tctgcgcaag ctgcttggaa      240

atgtttcttt gagtcttctc tataagtcta gtgttcatgg aggtagcatt gaagatatgg      300

ttgaaagatg cagccgtcag ggatgtacta taacaatggc ttacattgat tacaatatga      360

ttgtagcctt tatgcttgga aattatatta atttacatga aagttctaca gagccaaatg      420

attccctatg gttttcactt caaaagaaaa atgacaccac tgaaatagaa actttactct      480

taaatacagc accaaaaatt attgatgagc aactggtgtg tcgtttatcg aaaacggata      540

ttttcattat atgtcgagat aataaaattt atctagataa aatgataaca agaaacttga      600

aactaaggtt ttatggccac cgtcagtatt tggaatgtga agtttttcga gttgaaggaa      660

ttaaggataa cctagacgac ataaagagga taattaaagc cagagagcac agaaataggc      720

ttctagcaga catcagagac tataggccct atgcagactt ggtttcagaa attcgtattc      780

ttttggtggg tccagttggg tctggaaagt ccagtttttt caattcagtc aagtctattt      840

ttcatggcca tgtgactggc caagccgtag tggggtctga tatcaccagc ataaccgagc      900

ggtataggat atattctgtt aaagatggaa aaaatggaaa atctctgcca tttatgttgt      960

gtgacactat ggggctagat ggggcagaag gagcaggact gtgcatggat gacattcccc     1020

acatcttaaa aggttgtatg ccagacagat atcagtttaa ttcccgtaaa ccaattacac     1080

ctgagcattc tacttttatc acctctccat ctctgaagga caggattcac tgtgtggctt     1140

atgtcttaga catcaactct attgacaatc tctactctaa aatgttggca aaagtgaagc     1200

aagttcacaa agaagtatta aactgtggta tagcatatgt ggccttgctt actaaagtgg     1260

atgattgcag tgaggttctt caagacaact ttttaaacat gagtagatct atgacttctc     1320

aaagccgggt catgaatgtc cataaaatgc taggcattcc tatttccaat attttgatgg     1380

ttggaaacta tgcttcagat ttggaactgg accccatgaa ggatattctc atcctctctg     1440

cactgaggca gatgctgcgg gctgcagatg attttttaga agatttgcct cttgaggaaa     1500

ctggtgcaat tgagagagcg ttacagccct gcatttgaga taagttgcct tgattctgac     1560

atttggccca gcctgtactg gtgtgccgca atgagagtca atctctattg acagcctgct     1620

tcagattttg cttttgttcg ttttgccttc tgtccttgga acagtcatat ctcaagttca     1680

aaggccaaaa cctgagaagc ggtgggctaa gataggtcct actgcaaacc acccctccat     1740

atttccgtac catttacaat tcagtttctg tgacatcttt ttaaaccact ggaggaaaaa     1800

tgagatattc tctaatttat tcttctataa cactctatat agagctatgt gagtactaat     1860

cacattgaat aatagttata aaattattgt atagacatct gcttcttaaa cagattgtga     1920

gttctttgag aaacagcgtg gattttactt atctgtgtat tcacagagct tagcacagtg     1980

cctggtaatg agcaagcata cttgccatta cttttccttc ccactctctc caacatcaca     2040

ttcactttaa atttttctgt atatagaaag gaaaactagc ctgggcaaca tgatgaaacc     2100

ccatctccac tgcaaaaaaa aaaaaaaaaa ataagaaaga acaaaacaaa ccccacaaaa     2160

attagctggg tatgatggca cgtgcctgta gtcccagtta ctcaggatga ttgattgagc     2220

cttggaggtg gaggctacag tgagctgaga ttgtgccact gtactctagc cagggagaaa     2280

gagtgagatc ctggctcaaa aaaaccaaat aaaacaaaac aaacaaacga aaaacagaaa     2340

ggaagactga aagagaatga aaagctgggg agaggaaata aaaataaaga aggaagagtg     2400

tttcatttat atctgaatga aaatatgaat gactctaagt aattgaatta attaaaatga     2460

gccaactttt ttttaacaat ttacatttta tttctatggg aaaaaataaa tattcctctt     2520

ctaacaaacc catgcttgat tttcattaat tgaattccaa atcatcctag ccatgtgtcc     2580

ttccatttag gttactgggg caaatcagta agaaagttct tatatttatg ctccaaataa     2640

ttctgaagtc ctcttactag ctgtgaaagc tagtactatt aagaaagaaa acaaaattcc     2700

caaaagatag ctttcacttt tttttttcct taaagacttc ctaattctct tctccaaatt     2760

cttagtcttc ttcaaaataa tatgctttgg ttcaatagtt atccacattc tgacagtcta     2820

atttagtttt aatcagaatt atactcatct tttgggtagt catagatatt aagaaagcaa     2880

gagtttctta tgtccagtta tggaatattt cctaaagcaa ggctgcaggt gaagttgtgc     2940

tcaagtgaat gttcaggaga cacaattcag tggaagaaat taagtcttta aaaaagacct     3000

aggaatagga gaaccatgga aattgaggag gtaggcctac aagtagatat tgggaacaaa     3060

attagagagg caaccagaaa aagttatttt aggctcacca gagttgttct tattgcacag     3120

taacacacca atataccaaa acagcaggta ttgcagtaga gaaagagttt aataattgaa     3180

tggcagaaaa atgaggaagg ttgaggaaac ctcaaatcta cctccctgct gagtctaagt     3240

ttaggatttt taagagaaag gcaggtaagg tgctgaaggt ctggagctgc tgatttgttg     3300

gggtataggg aatgaaatga aacatacaga gatgaaaact ggaagttttt ttttgtttgt     3360

tttgtttttt ttttgttgtt gttttttttt ttttttgttt ttttgctgag tcaattcctt     3420

ggagggggtc ttcagactga ctggtgtcag cagacccatg ggattccaag atctggaaaa     3480

ctttttagat agaaacttga tgtttcttaa cgttacatat attatcttat agaaataact     3540

aagggaagtt agtgccttgt gaccacatct atgtgacttt taggcagtaa gaaactataa     3600

ggaaaggagc taacagtcat gctgtaagta gctacaggga attggcttaa agggcaagtt     3660

ggttagtact tagctgtgtt tttattcaaa gtctacattt tatgtagtgg ttaatgtttg     3720

ctgttcatta ggatggtttc acagttacca tacaaatgta gaagcaacag gtccaaaaag     3780

tagggcatga ttttctccat gtaatccagg gagaaaacaa gccatgacca ttgttggttg     3840

ggagactgaa ggtgattgaa ggttcaccat catcctcacc aacttttggg ccataattca     3900

cccaaccctt tggtggagcc tgaaaaaaat ctgggcagaa tgtaggactt ctttattttg     3960

tttaaagggg taacacagag tgcccttatg aaggagttgg agatcctgca aggaagagaa     4020

ggagtgaagg agagatcaag agagagaaac aatgaggaac atttcatttg acccaacatc     4080

ctttaggagc ataaatgttg acactaagtt atcccttttg tgctaaaatg gacagtattg     4140

gcaaaatgat accacaactt cttattctct ggctctatat tgctttggaa acacttaaac     4200

atcaaatgga gttaaataca tatttgaaat ttaggttagg aaatattggt gaggaggcct     4260

caaaaagggg gaaacatctt ttgtctggga ggatattttc cattttgtgg atttccctga     4320

tctttttcta ccaccctgag gggtggtggg aattatcatt ttgctacatt ttagaggtca     4380

tccaggattt ttgaaacttt acattcttta cggttaagca agatgtacag ctcagtcaaa     4440

gacactaaat tcttcttaga aaaatagtgc taaggagtat agcagatgac ctatatgtgt     4500

gttggctggg agaatatcat cttaaagtga gagtgatgtt gtggagacag ttgaaatgtc     4560

aatgctagag cctctgtggt gtgaatgggc acgttaggtt gttgcattag aaagtgactg     4620

tttctgacag aaatttgtag ctttgtgcaa actcacccac catctacctc aataaaatat     4680

agagaaaaga aaaatagagc agtttgagtt ctatgaggta tgcaggccca gagagacata     4740

agtatgttcc tttagtcttg cttcctgtgt gccacactgc ccctccacaa ccatagctgg     4800

gggcaattgt ttaaagtcat tttgttcccg actagctgcc ttgcacatta tcttcatttt     4860

cctggaattt gatacagaga gcaatttata gccaattgat agcttatgct gtttcaatgt     4920

aaattcgtgg taaataactt aggaactgcc tcttcttttt ctttgaaaac ctacttataa     4980

ctgttgctaa taagaatgtg tattgttcag gacaacttgt ctccatacag ttgggttgta     5040

accctcatgc ttggcccaaa taaactctct acttatatca gtttttccta cacttcttcc     5100

ttttaggtca acaataccaa gaggggttac tgtgctgggt aatgtgtaaa cttgtgtctt     5160

gtttagaaag ataaatttaa agactatcac attgcttttt cataaaacaa gacaggtcta     5220

caattaattt attttgacgc aaattgatag gggggccaag taagccccat atgcttaatg     5280

atcagctgat gaataatcat ctcctagcaa cataactcaa tctaatgcta aggtacccac     5340

aagatggcaa ggctgatcaa agtcgtcatg gaatcctgca accaaaagcc atgggaattt     5400

ggaagccctc aaatcccatt cctaatctga tgagtctatg gaccaatttg tggaggacag     5460

tagattaaat agatctgatt tttgccatca atgtaaggag gataaaaact tgcataccaa     5520

ttgtacaccc ttgcaaaatc tttctctgat gttggagaaa atgggccagt gagatcatgg     5580

atatagaagt acagtcaatg ttcagctgta ccctcccaca atcccacttc cttcctcaac     5640

acaattcaaa caaatagact cagactgttt caggctccag gacaggaagt gcagtgtagg     5700

caaaattgca aaaattgagg gcacaggggt ggaggtgggg gggttgaata acaagctgtg     5760

ctaaataatt acgtgtaaat atattttttc atttttaaaa attgatttct tttgcacatt     5820

ccatgacaat atatgtcaca tttttaaaat aaatgcaaag aagcatacat ccaaaaaaaa     5880

aaaaaaaaa                                                             5889


<210>  40
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Glu Val Thr Thr Arg Leu Thr Trp Asn Asp Glu Asn His Leu Arg 
1               5                   10                  15      


Lys Leu Leu Gly Asn Val Ser Leu Ser Leu Leu Tyr Lys Ser Ser Val 
            20                  25                  30          


His Gly Gly Ser Ile Glu Asp Met Val Glu Arg Cys Ser Arg Gln Gly 
        35                  40                  45              


Cys Thr Ile Thr Met Ala Tyr Ile Asp Tyr Asn Met Ile Val Ala Phe 
    50                  55                  60                  


Met Leu Gly Asn Tyr Ile Asn Leu His Glu Ser Ser Thr Glu Pro Asn 
65                  70                  75                  80  


Asp Ser Leu Trp Phe Ser Leu Gln Lys Lys Asn Asp Thr Thr Glu Ile 
                85                  90                  95      


Glu Thr Leu Leu Leu Asn Thr Ala Pro Lys Ile Ile Asp Glu Gln Leu 
            100                 105                 110         


Val Cys Arg Leu Ser Lys Thr Asp Ile Phe Ile Ile Cys Arg Asp Asn 
        115                 120                 125             


Lys Ile Tyr Leu Asp Lys Met Ile Thr Arg Asn Leu Lys Leu Arg Phe 
    130                 135                 140                 


Tyr Gly His Arg Gln Tyr Leu Glu Cys Glu Val Phe Arg Val Glu Gly 
145                 150                 155                 160 


Ile Lys Asp Asn Leu Asp Asp Ile Lys Arg Ile Ile Lys Ala Arg Glu 
                165                 170                 175     


His Arg Asn Arg Leu Leu Ala Asp Ile Arg Asp Tyr Arg Pro Tyr Ala 
            180                 185                 190         


Asp Leu Val Ser Glu Ile Arg Ile Leu Leu Val Gly Pro Val Gly Ser 
        195                 200                 205             


Gly Lys Ser Ser Phe Phe Asn Ser Val Lys Ser Ile Phe His Gly His 
    210                 215                 220                 


Val Thr Gly Gln Ala Val Val Gly Ser Asp Ile Thr Ser Ile Thr Glu 
225                 230                 235                 240 


Arg Tyr Arg Ile Tyr Ser Val Lys Asp Gly Lys Asn Gly Lys Ser Leu 
                245                 250                 255     


Pro Phe Met Leu Cys Asp Thr Met Gly Leu Asp Gly Ala Glu Gly Ala 
            260                 265                 270         


Gly Leu Cys Met Asp Asp Ile Pro His Ile Leu Lys Gly Cys Met Pro 
        275                 280                 285             


Asp Arg Tyr Gln Phe Asn Ser Arg Lys Pro Ile Thr Pro Glu His Ser 
    290                 295                 300                 


Thr Phe Ile Thr Ser Pro Ser Leu Lys Asp Arg Ile His Cys Val Ala 
305                 310                 315                 320 


Tyr Val Leu Asp Ile Asn Ser Ile Asp Asn Leu Tyr Ser Lys Met Leu 
                325                 330                 335     


Ala Lys Val Lys Gln Val His Lys Glu Val Leu Asn Cys Gly Ile Ala 
            340                 345                 350         


Tyr Val Ala Leu Leu Thr Lys Val Asp Asp Cys Ser Glu Val Leu Gln 
        355                 360                 365             


Asp Asn Phe Leu Asn Met Ser Arg Ser Met Thr Ser Gln Ser Arg Val 
    370                 375                 380                 


Met Asn Val His Lys Met Leu Gly Ile Pro Ile Ser Asn Ile Leu Met 
385                 390                 395                 400 


Val Gly Asn Tyr Ala Ser Asp Leu Glu Leu Asp Pro Met Lys Asp Ile 
                405                 410                 415     


Leu Ile Leu Ser Ala Leu Arg Gln Met Leu Arg Ala Ala Asp Asp Phe 
            420                 425                 430         


Leu Glu Asp Leu Pro Leu Glu Glu Thr Gly Ala Ile Glu Arg Ala Leu 
        435                 440                 445             


Gln Pro Cys Ile 
    450         


<210>  41
<211>  2961
<212>  DNA
<213>  Homo sapiens

<400>  41
aagagatgat ttctccatcc tgaacgtgca gcgagcttgt caggaagatc ggaggtgcca       60

agtagcagag aaagcatccc ccagctctga cagggagaca gcacatgtct aaggcccaca      120

agccttggcc ctaccggagg agaagtcaat tttcttctcg aaaatacctg aaaaaagaaa      180

tgaattcctt ccagcaacag ccaccgccat tcggcacagt gccaccacaa atgatgtttc      240

ctccaaactg gcagggggca gagaaggacg ctgctttcct cgccaaggac ttcaactttc      300

tcactttgaa caatcagcca ccaccaggaa acaggagcca accaagggca atggggcccg      360

agaacaacct gtacagccag tacgagcaga aggtgcgccc ctgcattgac ctcatcgact      420

ccctgcgggc tctgggtgtg gagcaggacc tggccctgcc agccatcgcc gtcatcgggg      480

accagagctc gggcaagagc tctgtgctgg aggcactgtc aggagtcgcg cttcccagag      540

gcagcggaat cgtaaccagg tgtccgctgg tgctgaaact gaaaaagcag ccctgtgagg      600

catgggccgg aaggatcagc taccggaaca ccgagctaga gcttcaggac cctggccagg      660

tggagaaaga gatacacaaa gcccagaacg tcatggccgg gaatggccgg ggcatcagcc      720

atgagctcat cagcctggag atcacctccc ctgaggttcc agacctgacc atcattgacc      780

ttcccggcat caccagggtg gctgtggaca accagccccg agacatcgga ctgcagatca      840

aggctctcat caagaagtac atccagaggc agcagacgat caacttggtg gtggttccct      900

gtaacgtgga cattgccacc acggaggcgc tgagcatggc ccatgaggtg gacccggaag      960

gggacaggac catcggtatc ctgaccaaac cagatctaat ggacaggggc actgagaaaa     1020

gcgtcatgaa tgtggtgcgg aacctcacgt accccctcaa gaagggctac atgattgtga     1080

agtgccgggg ccagcaggag atcacaaaca ggctgagctt ggcagaggca accaagaaag     1140

aaattacatt ctttcaaaca catccatatt tcagagttct cctggaggag gggtcagcca     1200

cggttccccg actggcagaa agacttacca ctgaactcat catgcatatc caaaaatcgc     1260

tcccgttgtt agaaggacaa ataagggaga gccaccagaa ggcgaccgag gagctgcggc     1320

gttgcggggc tgacatcccc agccaggagg ccgacaagat gttctttcta attgagaaaa     1380

tcaagatgtt taatcaggac atcgaaaagt tagtagaagg agaagaagtt gtaagggaga     1440

atgagacccg tttatacaac aaaatcagag aggattttaa aaactgggta ggcatacttg     1500

caactaatac ccaaaaagtt aaaaatatta tccacgaaga agttgaaaaa tatgaaaagc     1560

agtatcgagg caaggagctt ctgggatttg tcaactacaa gacatttgag atcatcgtgc     1620

atcagtacat ccagcagctg gtggagcccg cccttagcat gctccagaaa gccatggaaa     1680

ttatccagca agctttcatt aacgtggcca aaaaacattt tggcgaattt ttcaacctta     1740

accaaactgt tcagagcacg attgaagaca taaaagtgaa acacacagca aaggcagaaa     1800

acatgatcca acttcagttc agaatggagc agatggtttt ttgtcaagat cagatttaca     1860

gtgttgttct gaagaaagtc cgagaagaga tttttaaccc tctggggacg ccttcacaga     1920

atatgaagtt gaactctcat tttcccagta atgagtcttc ggtttcctcc tttactgaaa     1980

taggcatcca cctgaatgcc tacttcttgg aaaccagcaa acgtctcgcc aaccagatcc     2040

catttataat tcagtatttt atgctccgag agaatggtga ctccttgcag aaagccatga     2100

tgcagatact acaggaaaaa aatcgctatt cctggctgct tcaagagcag agtgagaccg     2160

ctaccaagag aagaatcctt aaggagagaa tttaccggct cactcaggcg cgacacgcac     2220

tctgtcaatt ctccagcaaa gagatccact gaagggcggc gatgcctgtg gttgttttct     2280

tgtgcgtact cattcattct aaggggagtc ggtgcaggat gccgcttctg ctttggggcc     2340

aaactcttct gtcactatca gtgtccatct ctactgtact ccctcagcat cagagcatgc     2400

atcaggggtc cacacaggct cagctctctc caccacccag ctcttccctg accttcacga     2460

agggatggct ctccagtcct tgggtcccgt agcacacagt tacagtgtcc taagatactg     2520

ctatcattct tcgctaattt gtatttgtat tcccttcccc ctacaagatt atgagacccc     2580

agagggggaa ggtctgggtc aaattcttct tttgtatgtc cagtctcctg cacagcacct     2640

gcagcattgt aactgcttaa taaatgacat ctcactgaac gaatgagtgc tgtgtaagtg     2700

atggagatac ctgaggctat tgctcaagcc caggccttgg acatttagtg actgttagcc     2760

ggtccctttc agatccagtg gccatgcccc ctgcttccca tggttcactg tcattgtgtt     2820

tcccagcctc tccactcccc cgccagaaag gagcctgagt gattctcttt tcttcttgtt     2880

tccctgatta tgatgagctt ccattgttct gttaagtctt gaagaggaat ttaataaagc     2940

aaagaaactt tttaaaaacg t                                               2961


<210>  42
<211>  715
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ser Lys Ala His Lys Pro Trp Pro Tyr Arg Arg Arg Ser Gln Phe 
1               5                   10                  15      


Ser Ser Arg Lys Tyr Leu Lys Lys Glu Met Asn Ser Phe Gln Gln Gln 
            20                  25                  30          


Pro Pro Pro Phe Gly Thr Val Pro Pro Gln Met Met Phe Pro Pro Asn 
        35                  40                  45              


Trp Gln Gly Ala Glu Lys Asp Ala Ala Phe Leu Ala Lys Asp Phe Asn 
    50                  55                  60                  


Phe Leu Thr Leu Asn Asn Gln Pro Pro Pro Gly Asn Arg Ser Gln Pro 
65                  70                  75                  80  


Arg Ala Met Gly Pro Glu Asn Asn Leu Tyr Ser Gln Tyr Glu Gln Lys 
                85                  90                  95      


Val Arg Pro Cys Ile Asp Leu Ile Asp Ser Leu Arg Ala Leu Gly Val 
            100                 105                 110         


Glu Gln Asp Leu Ala Leu Pro Ala Ile Ala Val Ile Gly Asp Gln Ser 
        115                 120                 125             


Ser Gly Lys Ser Ser Val Leu Glu Ala Leu Ser Gly Val Ala Leu Pro 
    130                 135                 140                 


Arg Gly Ser Gly Ile Val Thr Arg Cys Pro Leu Val Leu Lys Leu Lys 
145                 150                 155                 160 


Lys Gln Pro Cys Glu Ala Trp Ala Gly Arg Ile Ser Tyr Arg Asn Thr 
                165                 170                 175     


Glu Leu Glu Leu Gln Asp Pro Gly Gln Val Glu Lys Glu Ile His Lys 
            180                 185                 190         


Ala Gln Asn Val Met Ala Gly Asn Gly Arg Gly Ile Ser His Glu Leu 
        195                 200                 205             


Ile Ser Leu Glu Ile Thr Ser Pro Glu Val Pro Asp Leu Thr Ile Ile 
    210                 215                 220                 


Asp Leu Pro Gly Ile Thr Arg Val Ala Val Asp Asn Gln Pro Arg Asp 
225                 230                 235                 240 


Ile Gly Leu Gln Ile Lys Ala Leu Ile Lys Lys Tyr Ile Gln Arg Gln 
                245                 250                 255     


Gln Thr Ile Asn Leu Val Val Val Pro Cys Asn Val Asp Ile Ala Thr 
            260                 265                 270         


Thr Glu Ala Leu Ser Met Ala His Glu Val Asp Pro Glu Gly Asp Arg 
        275                 280                 285             


Thr Ile Gly Ile Leu Thr Lys Pro Asp Leu Met Asp Arg Gly Thr Glu 
    290                 295                 300                 


Lys Ser Val Met Asn Val Val Arg Asn Leu Thr Tyr Pro Leu Lys Lys 
305                 310                 315                 320 


Gly Tyr Met Ile Val Lys Cys Arg Gly Gln Gln Glu Ile Thr Asn Arg 
                325                 330                 335     


Leu Ser Leu Ala Glu Ala Thr Lys Lys Glu Ile Thr Phe Phe Gln Thr 
            340                 345                 350         


His Pro Tyr Phe Arg Val Leu Leu Glu Glu Gly Ser Ala Thr Val Pro 
        355                 360                 365             


Arg Leu Ala Glu Arg Leu Thr Thr Glu Leu Ile Met His Ile Gln Lys 
    370                 375                 380                 


Ser Leu Pro Leu Leu Glu Gly Gln Ile Arg Glu Ser His Gln Lys Ala 
385                 390                 395                 400 


Thr Glu Glu Leu Arg Arg Cys Gly Ala Asp Ile Pro Ser Gln Glu Ala 
                405                 410                 415     


Asp Lys Met Phe Phe Leu Ile Glu Lys Ile Lys Met Phe Asn Gln Asp 
            420                 425                 430         


Ile Glu Lys Leu Val Glu Gly Glu Glu Val Val Arg Glu Asn Glu Thr 
        435                 440                 445             


Arg Leu Tyr Asn Lys Ile Arg Glu Asp Phe Lys Asn Trp Val Gly Ile 
    450                 455                 460                 


Leu Ala Thr Asn Thr Gln Lys Val Lys Asn Ile Ile His Glu Glu Val 
465                 470                 475                 480 


Glu Lys Tyr Glu Lys Gln Tyr Arg Gly Lys Glu Leu Leu Gly Phe Val 
                485                 490                 495     


Asn Tyr Lys Thr Phe Glu Ile Ile Val His Gln Tyr Ile Gln Gln Leu 
            500                 505                 510         


Val Glu Pro Ala Leu Ser Met Leu Gln Lys Ala Met Glu Ile Ile Gln 
        515                 520                 525             


Gln Ala Phe Ile Asn Val Ala Lys Lys His Phe Gly Glu Phe Phe Asn 
    530                 535                 540                 


Leu Asn Gln Thr Val Gln Ser Thr Ile Glu Asp Ile Lys Val Lys His 
545                 550                 555                 560 


Thr Ala Lys Ala Glu Asn Met Ile Gln Leu Gln Phe Arg Met Glu Gln 
                565                 570                 575     


Met Val Phe Cys Gln Asp Gln Ile Tyr Ser Val Val Leu Lys Lys Val 
            580                 585                 590         


Arg Glu Glu Ile Phe Asn Pro Leu Gly Thr Pro Ser Gln Asn Met Lys 
        595                 600                 605             


Leu Asn Ser His Phe Pro Ser Asn Glu Ser Ser Val Ser Ser Phe Thr 
    610                 615                 620                 


Glu Ile Gly Ile His Leu Asn Ala Tyr Phe Leu Glu Thr Ser Lys Arg 
625                 630                 635                 640 


Leu Ala Asn Gln Ile Pro Phe Ile Ile Gln Tyr Phe Met Leu Arg Glu 
                645                 650                 655     


Asn Gly Asp Ser Leu Gln Lys Ala Met Met Gln Ile Leu Gln Glu Lys 
            660                 665                 670         


Asn Arg Tyr Ser Trp Leu Leu Gln Glu Gln Ser Glu Thr Ala Thr Lys 
        675                 680                 685             


Arg Arg Ile Leu Lys Glu Arg Ile Tyr Arg Leu Thr Gln Ala Arg His 
    690                 695                 700                 


Ala Leu Cys Gln Phe Ser Ser Lys Glu Ile His 
705                 710                 715 


<210>  43
<211>  3512
<212>  DNA
<213>  Homo sapiens

<400>  43
aactcagctg agtgttagtc aaagaaggtg tgtcctgctc cccaatgaca ggttgctcag       60

agactgctga tttccatccc tatataaaga gagtccctgg catacagaga ctgctctgct      120

ccaggcatct gccacaatgt gggtgcttac acctgctgct tttgctggga agctcttgag      180

tgtgttcagg caacctctga gctctctgtg gaggagcctg gtcccgctgt tctgctggct      240

gagggcaacc ttctggctgc tagctaccaa gaggagaaag cagcagctgg tcctgagagg      300

gccagatgag accaaagagg aggaagagga ccctcctctg cccaccaccc caaccagcgt      360

caactatcac ttcactcgcc agtgcaacta caaatgcggc ttctgtttcc acacagccaa      420

aacatccttt gtgctgcccc ttgaggaagc aaagagagga ttgcttttgc ttaaggaagc      480

tggtatggag aagatcaact tttcaggtgg agagccattt cttcaagacc ggggagaata      540

cctgggcaag ttggtgaggt tctgcaaagt agagttgcgg ctgcccagcg tgagcatcgt      600

gagcaatgga agcctgatcc gggagaggtg gttccagaat tatggtgagt atttggacat      660

tctcgctatc tcctgtgaca gctttgacga ggaagtcaat gtccttattg gccgtggcca      720

aggaaagaag aaccatgtgg aaaaccttca aaagctgagg aggtggtgta gggattatag      780

agtcgctttc aagataaatt ctgtcattaa tcgtttcaac gtggaagagg acatgacgga      840

acagatcaaa gcactaaacc ctgtccgctg gaaagtgttc cagtgcctct taattgaggg      900

tgagaattgt ggagaagatg ctctaagaga agcagaaaga tttgttattg gtgatgaaga      960

atttgaaaga ttcttggagc gccacaaaga agtgtcctgc ttggtgcctg aatctaacca     1020

gaagatgaaa gactcctacc ttattctgga tgaatatatg cgctttctga actgtagaaa     1080

gggacggaag gacccttcca agtccatcct ggatgttggt gtagaagaag ctataaaatt     1140

cagtggattt gatgaaaaga tgtttctgaa gcgaggagga aaatacatat ggagtaaggc     1200

tgatctgaag ctggattggt agagcggaaa gtggaacgag acttcaacac accagtggga     1260

aaactcctag agtaactgcc attgtctgca atactatccc gttggtattt cccagtggct     1320

gaaaacctga ttttctgctg cacgtggcat ctgattacct gtggtcactg aacacacgaa     1380

taacttggat agcaaatcct gagacaatgg aaaaccatta actttacttc attggcttat     1440

aaccttgttg ttattgaaac agcacttctg tttttgagtt tgttttagct aaaaagaagg     1500

aatacacaca ggaataatga ccccaaaaat gcttagataa ggcccctata cacaggacct     1560

gacatttagc tcaatgatgc gtttgtaaga aataagctct agtgatatct gtgggggcaa     1620

aatttaattt ggatttgatt ttttaaaaca atgtttactg cgatttctat atttccattt     1680

tgaaactatt tcttgttcca ggtttgttca tttgacagag tcagtatttt ttgccaaata     1740

tccagataac cagttttcac atctgagaca ttacaaagta tctgcctcaa ttatttctgc     1800

tggttataat gctttttttt ttttgccttt atgccattgc agtcttgtac tttttactgt     1860

gatgtacaga aatagtcaac agatgtttcc aagaacatat gatatgataa tcctaccaat     1920

tttcaagaag tctctagaaa gagataacac atggaaagac ggtgtggtgc agcccagccc     1980

acggtggctg ttccatgaat gctggctacc tatgtgtgtg gtacctgttg tgtccctttc     2040

tcttcaaaga tcctgagcaa aacaaagata cgctttccat ttgatgatgg agttgacatg     2100

gaggcagtgc ttgcattgct ttgttcgcct atcatctggc cacatgaggc tgtcaagcaa     2160

aagaatagga gtgtagttga gtagctggtt ggccctacat ctctgagaag tgacggcaca     2220

ctgggttggc ataagatatc ctaaaatcac gctggaacct tgggcaagga agaatgtgag     2280

caagagtaga gagagtgcct ggatttcatg tcagtgaagc caagtcacca tatcatattt     2340

ttgaatgaac tctgagtcag ttgaaatagg gtaccatcta ggtcagttta agaagagtca     2400

gctcagagaa agcaagcata agggaaaatg tcacgtaaac tagatcaggg aacaaaatcc     2460

tctccttgtg gaaatatccc atgcagtttg ttgatacaac ttagtatctt attgcctaaa     2520

aaaaaatttc ttatcattgt ttcaaaaaag caaaatcatg gaaaattttt gttgtccagg     2580

caaataaaag gtcattttaa tttagctgca atttcagtgt tcctcactag gtggcattta     2640

aatgtcgcct gatgtcatta agcaccatcc aaaaagtctg cttcataatc tattttcaag     2700

acttggtgat tctgaaagtt ttggtttttg tgactttgtt tctcaggaaa aaaaatattc     2760

ctacttaaat tttaagtcta taattcaatt taaatatgtg tgtgtctcat ccaggatagg     2820

ataggttgtc ttctattttc cattttacct atttactttt tttgtaagaa aagagaaaaa     2880

tgaattctaa agatgttccc catgggtttt gattgtgtct aagctatgat gaccttcata     2940

taatcagcat aaacataaaa caaatttttt acttaacatg agtgcacttt actaatcctc     3000

atggcacagt ggctcacgcc tgtaatccca gcacttggga ggacaatgtg ggtggatcac     3060

gaggtcagga gttcgagaac agcctggcca acatggtgaa accccgtctc cactaaaaat     3120

acaaaaatta gccaggcatg gtggcgtaca cttgtaattc cagctactca agaggctgag     3180

gcaggaggat tgcttgaacc ctgaaggcag aggttacaga gccaagatag cgccactgca     3240

ctccagcctg gatgacagag caagactccg tctcaaaaaa aaaaaaaaaa aaaagcaaga     3300

gagttcaact aagaaaggtc acatatgtga aagcccaagg acactgtttg atatacagca     3360

ggtattcaat cagtgttatt tgaaaccaaa tctgaatttg aagtttgaat cttctgagtt     3420

ggaatgaatt tttttctagc tgagggaaac tgtatttttc tttccccaaa gaggaatgta     3480

atgtaaagtg aaataaaact ataagctatg tt                                   3512


<210>  44
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Trp Val Leu Thr Pro Ala Ala Phe Ala Gly Lys Leu Leu Ser Val 
1               5                   10                  15      


Phe Arg Gln Pro Leu Ser Ser Leu Trp Arg Ser Leu Val Pro Leu Phe 
            20                  25                  30          


Cys Trp Leu Arg Ala Thr Phe Trp Leu Leu Ala Thr Lys Arg Arg Lys 
        35                  40                  45              


Gln Gln Leu Val Leu Arg Gly Pro Asp Glu Thr Lys Glu Glu Glu Glu 
    50                  55                  60                  


Asp Pro Pro Leu Pro Thr Thr Pro Thr Ser Val Asn Tyr His Phe Thr 
65                  70                  75                  80  


Arg Gln Cys Asn Tyr Lys Cys Gly Phe Cys Phe His Thr Ala Lys Thr 
                85                  90                  95      


Ser Phe Val Leu Pro Leu Glu Glu Ala Lys Arg Gly Leu Leu Leu Leu 
            100                 105                 110         


Lys Glu Ala Gly Met Glu Lys Ile Asn Phe Ser Gly Gly Glu Pro Phe 
        115                 120                 125             


Leu Gln Asp Arg Gly Glu Tyr Leu Gly Lys Leu Val Arg Phe Cys Lys 
    130                 135                 140                 


Val Glu Leu Arg Leu Pro Ser Val Ser Ile Val Ser Asn Gly Ser Leu 
145                 150                 155                 160 


Ile Arg Glu Arg Trp Phe Gln Asn Tyr Gly Glu Tyr Leu Asp Ile Leu 
                165                 170                 175     


Ala Ile Ser Cys Asp Ser Phe Asp Glu Glu Val Asn Val Leu Ile Gly 
            180                 185                 190         


Arg Gly Gln Gly Lys Lys Asn His Val Glu Asn Leu Gln Lys Leu Arg 
        195                 200                 205             


Arg Trp Cys Arg Asp Tyr Arg Val Ala Phe Lys Ile Asn Ser Val Ile 
    210                 215                 220                 


Asn Arg Phe Asn Val Glu Glu Asp Met Thr Glu Gln Ile Lys Ala Leu 
225                 230                 235                 240 


Asn Pro Val Arg Trp Lys Val Phe Gln Cys Leu Leu Ile Glu Gly Glu 
                245                 250                 255     


Asn Cys Gly Glu Asp Ala Leu Arg Glu Ala Glu Arg Phe Val Ile Gly 
            260                 265                 270         


Asp Glu Glu Phe Glu Arg Phe Leu Glu Arg His Lys Glu Val Ser Cys 
        275                 280                 285             


Leu Val Pro Glu Ser Asn Gln Lys Met Lys Asp Ser Tyr Leu Ile Leu 
    290                 295                 300                 


Asp Glu Tyr Met Arg Phe Leu Asn Cys Arg Lys Gly Arg Lys Asp Pro 
305                 310                 315                 320 


Ser Lys Ser Ile Leu Asp Val Gly Val Glu Glu Ala Ile Lys Phe Ser 
                325                 330                 335     


Gly Phe Asp Glu Lys Met Phe Leu Lys Arg Gly Gly Lys Tyr Ile Trp 
            340                 345                 350         


Ser Lys Ala Asp Leu Lys Leu Asp Trp 
        355                 360     


<210>  45
<211>  4034
<212>  DNA
<213>  Homo sapiens

<400>  45
agtttctgag cgctcggcat ctgattcaat ctccagtttc ctgttcttgc tggggctggg       60

gtctctcctt taacaaagac acgccgcgcg gccgagtcca ggggctgcag aggcctggcg      120

cgcgcacgcg cacgcgcacg cccaccgcgc ggcttcccgc ggtccccggt gctgaggaga      180

gagcgatccg agggactgcg ccgcccggac ggcctgcaga gcgctgccat catgagtgaa      240

attcgtaagg acaccttgaa ggccattctg ttggagttag aatgtcattt tacatggaat      300

ttacttaagg aagacattga tctgtttgag gtagaagata caattgggca acagcttgaa      360

tttcttacca caaaatctag acttgctctt tataacctat tggcctatgt gaaacaccta      420

aaaggccaaa ataaagacgc ccttgagtgc ttggaacaag cagaagaaat aatccagcaa      480

gaacactcag acaaagaaga agtacgaagc ctggtcactt ggggaaacta tgcctgggtg      540

tattatcaca tggaccagct tgaagaagct cagaagtata caggtaagat agggaatgtc      600

tgtaagaaat tgtccagtcc ttctaactac aagttggagt gtcctgagac tgactgtgag      660

aaaggctggg cactcttgaa atttggagga aagtattatc aaaaggctaa agcggctttt      720

gagaaggctc tggaagtgga gcctgacaat ccagaattta acatcggcta tgctatcaca      780

gtgtatcggc tggatgattc tgatagagaa gggtctgtaa agagcttttc tctggggcct      840

ttgagaaagg ctgttaccct gaacccagat aacagctata ttaaggtttt tctggcactg      900

aagcttcaag atgtacatgc agaagctgaa ggggaaaagt atattgaaga aatcctggac      960

caaatatcat cccagcctta cgtccttcgt tatgcagcca agttctatag gagaaaaaat     1020

tcctggaaca aagctctcga acttttaaaa aaggccttgg aggtgacacc aacttcttct     1080

ttcctgcatc accagatggg actttgctac agggcacaaa tgatccaaat caagaaggcc     1140

acacacaaca gacctaaagg aaaggataaa ctaaaggttg atgagctgat ttcatctgct     1200

atatttcatt tcaaagcagc catggaacga gactctatgt ttgcatttgc ctacacagac     1260

ctggccaaca tgtacgctga aggaggccag tatagcaatg ctgaggacat tttccggaaa     1320

gctcttcgtc tggagaacat aaccgatgat cacaaacatc agatccatta ccactatggc     1380

cgctttcagg aatttcaccg taaatcagaa aatactgcca tccatcatta tttagaagcc     1440

ttaaaggtca aagacagatc accccttcgc accaaactga caagtgctct gaagaaattg     1500

tctaccaaga gactttgtca caatgcttta gatgtgcaga gtttaagtgc cctagggttt     1560

gtttacaagc tggaaggaga aaagaggcaa gctgctgagt actatgagaa ggcacaaaag     1620

atagatccag aaaatgcaga attcctgact gctctctgtg agctccgact ttccatttaa     1680

atacatactc taggaaatta gctctaagtt tttcccttca ttttgggttc tcctgtttgt     1740

ttttttttta ttattttaat cccttgttta ttatagagct aatatttatt gaatagttat     1800

tgtgtaccaa gcattgtgct aaatacttta tatgcattat gatgaatctt gtgcggtttt     1860

ctttcttttt ttctttttaa ttaaaatact ataatccatt gagaaatagc aatattctag     1920

ctattgtaac ttctaaaaat ggtatggcca ttagatctgt gctttttatc tctgctcttt     1980

gaatttctca tattatatag taaatatatt cctacgtaaa cctttgatac ctagatcagg     2040

aatactcttc caggagtaca aaattacatt attgatagtt aagctcttaa ttgtgtagct     2100

tgcaaaagac agcacttttt agttacagat gttttgactt tgatgaggat atttagctat     2160

caatctaata gtcacctaaa atatcttttt tgttggaaaa aagtttataa taaaaaagtt     2220

tgtcatctct agtgacttca ataaagaaaa aactagaaga ggagaaaaag gatttcctca     2280

aattttaaat atgtaacttc agggattcaa tccccaaatg tttattaagt agctagaaat     2340

aattatgtgg aaaaaaatga ataatggaaa atagtgagtc tcaaattgtt ctcttttttt     2400

ttttaactaa aacaaatctg caatgaatct agatgcaatt aattttattc cttccaacta     2460

aaattacaat atttttaggt taaaattatt gagatataaa gcagccattg ggaaattggg     2520

agaaatgata aacaaatgga aaaagaagat gtccctaacc tacacccata gattaccaag     2580

gtttcagtgt actagttttg aatctgttct gaatggagtt tttataccct caatttctgg     2640

cctttggcta ttttagcatt tcaaagtgac ttctatgaag cttttttttt aatgtgaaat     2700

tttcagaatg ttgttttttt catgtagata ctccaggaag agttaagcac tgctttcagt     2760

tttaatatcc accttgaggg gtcgctgctt gagggctctt atcccagggg actttttaat     2820

tcggatgtta cttaatgtgg cttctctaat gtagtttctt tgattaccga ctacacaatt     2880

atgtaccatc acagtattag tggaaaagta ccatgtgatt taattctcca ttcctccaat     2940

gtaactctta aaattattat gtatgtgtgt gtgttttact ttttgttttt tatcatcttt     3000

aaaatttcta ttatggtttg attattataa aaataatgaa ttctcactgt aaatttcaaa     3060

aaaaaattac aaaagtatgt gaatttaaaa atgagagcag tcctctcacc ctaccacagt     3120

tccacaccct caaggtaaac ttataactta taatttgata tgtaaacttc cagatctttt     3180

ttctatgcgt aatcagacat acatatatac tgcagtgtat ctcacgtatt aatttttaaa     3240

aatcttttgt tttacttaat tctgttttta ttattattat tattttgttt gatctattaa     3300

ggaagaacaa ggaagggaat gatctttact caagaatttc agaaagtcag cactgaagtc     3360

ctgacctatc agtagacaca tttgtccctt tcagatattt taggatattc tagcaaagca     3420

ggccatttct cccacctgaa agtacataac ttctatcact tgccacataa ttaaaagaac     3480

tcacattaag cggttactca gacagttaat catagaaaag attatttgct tcatcagttc     3540

atagaaaaga ttatttgctt catcagttaa cttgttttta taaatcaggg ctgtgttcat     3600

acacagaagg ggcctgagat ttctgcactt taaacaagct cctcctaggt gaggatgctg     3660

tggctgttct aattacattt tgagtagtaa ggtctacagc attgttcctc aaacttggct     3720

acgtattgga atcacctaaa aagttaaaac aaaacatgga tgtctgggtc ccgccccata     3780

gagaatgact taattggcat ggggtgcagt ccaggcatca tgatttttag atttcccagt     3840

tggaacttgt gcagcaaagt ttgggagcta ctgatggaca tgtgaaaagt aagtataaat     3900

ggaataaaat taattaggct aataggctta acccaggaaa tcctaagttc cttgaatatc     3960

cagtttgcat ttggactcct catcatatac ttggtatata atactctaat aaaagctgcc     4020

tgagttgaat tgta                                                       4034


<210>  46
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ser Glu Ile Arg Lys Asp Thr Leu Lys Ala Ile Leu Leu Glu Leu 
1               5                   10                  15      


Glu Cys His Phe Thr Trp Asn Leu Leu Lys Glu Asp Ile Asp Leu Phe 
            20                  25                  30          


Glu Val Glu Asp Thr Ile Gly Gln Gln Leu Glu Phe Leu Thr Thr Lys 
        35                  40                  45              


Ser Arg Leu Ala Leu Tyr Asn Leu Leu Ala Tyr Val Lys His Leu Lys 
    50                  55                  60                  


Gly Gln Asn Lys Asp Ala Leu Glu Cys Leu Glu Gln Ala Glu Glu Ile 
65                  70                  75                  80  


Ile Gln Gln Glu His Ser Asp Lys Glu Glu Val Arg Ser Leu Val Thr 
                85                  90                  95      


Trp Gly Asn Tyr Ala Trp Val Tyr Tyr His Met Asp Gln Leu Glu Glu 
            100                 105                 110         


Ala Gln Lys Tyr Thr Gly Lys Ile Gly Asn Val Cys Lys Lys Leu Ser 
        115                 120                 125             


Ser Pro Ser Asn Tyr Lys Leu Glu Cys Pro Glu Thr Asp Cys Glu Lys 
    130                 135                 140                 


Gly Trp Ala Leu Leu Lys Phe Gly Gly Lys Tyr Tyr Gln Lys Ala Lys 
145                 150                 155                 160 


Ala Ala Phe Glu Lys Ala Leu Glu Val Glu Pro Asp Asn Pro Glu Phe 
                165                 170                 175     


Asn Ile Gly Tyr Ala Ile Thr Val Tyr Arg Leu Asp Asp Ser Asp Arg 
            180                 185                 190         


Glu Gly Ser Val Lys Ser Phe Ser Leu Gly Pro Leu Arg Lys Ala Val 
        195                 200                 205             


Thr Leu Asn Pro Asp Asn Ser Tyr Ile Lys Val Phe Leu Ala Leu Lys 
    210                 215                 220                 


Leu Gln Asp Val His Ala Glu Ala Glu Gly Glu Lys Tyr Ile Glu Glu 
225                 230                 235                 240 


Ile Leu Asp Gln Ile Ser Ser Gln Pro Tyr Val Leu Arg Tyr Ala Ala 
                245                 250                 255     


Lys Phe Tyr Arg Arg Lys Asn Ser Trp Asn Lys Ala Leu Glu Leu Leu 
            260                 265                 270         


Lys Lys Ala Leu Glu Val Thr Pro Thr Ser Ser Phe Leu His His Gln 
        275                 280                 285             


Met Gly Leu Cys Tyr Arg Ala Gln Met Ile Gln Ile Lys Lys Ala Thr 
    290                 295                 300                 


His Asn Arg Pro Lys Gly Lys Asp Lys Leu Lys Val Asp Glu Leu Ile 
305                 310                 315                 320 


Ser Ser Ala Ile Phe His Phe Lys Ala Ala Met Glu Arg Asp Ser Met 
                325                 330                 335     


Phe Ala Phe Ala Tyr Thr Asp Leu Ala Asn Met Tyr Ala Glu Gly Gly 
            340                 345                 350         


Gln Tyr Ser Asn Ala Glu Asp Ile Phe Arg Lys Ala Leu Arg Leu Glu 
        355                 360                 365             


Asn Ile Thr Asp Asp His Lys His Gln Ile His Tyr His Tyr Gly Arg 
    370                 375                 380                 


Phe Gln Glu Phe His Arg Lys Ser Glu Asn Thr Ala Ile His His Tyr 
385                 390                 395                 400 


Leu Glu Ala Leu Lys Val Lys Asp Arg Ser Pro Leu Arg Thr Lys Leu 
                405                 410                 415     


Thr Ser Ala Leu Lys Lys Leu Ser Thr Lys Arg Leu Cys His Asn Ala 
            420                 425                 430         


Leu Asp Val Gln Ser Leu Ser Ala Leu Gly Phe Val Tyr Lys Leu Glu 
        435                 440                 445             


Gly Glu Lys Arg Gln Ala Ala Glu Tyr Tyr Glu Lys Ala Gln Lys Ile 
    450                 455                 460                 


Asp Pro Glu Asn Ala Glu Phe Leu Thr Ala Leu Cys Glu Leu Arg Leu 
465                 470                 475                 480 


Ser Ile 
        


<210>  47
<211>  733
<212>  DNA
<213>  Homo sapiens

<400>  47
aaacagcagg aaatagaaac ttaagagaaa tacacacttc tgagaaactg aaacgacagg       60

ggaaaggagg tctcactgag caccgtccca gcatccggac accacagcgg cccttcgctc      120

cacgcagaaa accacacttc tcaaaccttc actcaacact tccttcccca aagccagaag      180

atgcacaagg aggaacatga ggtggctgtg ctgggggcac cccccagcac catccttcca      240

aggtccaccg tgatcaacat ccacagcgag acctccgtgc ccgaccatgt cgtctggtcc      300

ctgttcaaca ccctcttctt gaactggtgc tgtctgggct tcatagcatt cgcctactcc      360

gtgaagtcta gggacaggaa gatggttggc gacgtgaccg gggcccaggc ctatgcctcc      420

accgccaagt gcctgaacat ctgggccctg attctgggca tcctcatgac cattggattc      480

atcctgttac tggtattcgg ctctgtgaca gtctaccata ttatgttaca gataatacag      540

gaaaaacggg gttactagta gccgcccata gcctgcaacc tttgcactcc actgtgcaat      600

gctggccctg cacgctgggg ctgttgcccc tgcccccttg gtcctgcccc tagatacagc      660

agtttatacc cacacacctg tctacagtgt cattcaataa agtgcacgtg cttgtgaaaa      720

aaaaaaaaaa aaa                                                         733


<210>  48
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  48

Met His Lys Glu Glu His Glu Val Ala Val Leu Gly Ala Pro Pro Ser 
1               5                   10                  15      


Thr Ile Leu Pro Arg Ser Thr Val Ile Asn Ile His Ser Glu Thr Ser 
            20                  25                  30          


Val Pro Asp His Val Val Trp Ser Leu Phe Asn Thr Leu Phe Leu Asn 
        35                  40                  45              


Trp Cys Cys Leu Gly Phe Ile Ala Phe Ala Tyr Ser Val Lys Ser Arg 
    50                  55                  60                  


Asp Arg Lys Met Val Gly Asp Val Thr Gly Ala Gln Ala Tyr Ala Ser 
65                  70                  75                  80  


Thr Ala Lys Cys Leu Asn Ile Trp Ala Leu Ile Leu Gly Ile Leu Met 
                85                  90                  95      


Thr Ile Gly Phe Ile Leu Leu Leu Val Phe Gly Ser Val Thr Val Tyr 
            100                 105                 110         


His Ile Met Leu Gln Ile Ile Gln Glu Lys Arg Gly Tyr 
        115                 120                 125 


<210>  49
<211>  678
<212>  DNA
<213>  Homo sapiens

<400>  49
aggaaaagga aactgttgag aaaccgaaac tactggggaa agggagggct cactgagaac       60

catcccagta acccgaccgc cgctggtctt cgctggacac catgaatcac actgtccaaa      120

ccttcttctc tcctgtcaac agtggccagc cccccaacta tgagatgctc aaggaggagc      180

acgaggtggc tgtgctgggg gcgccccaca accctgctcc cccgacgtcc accgtgatcc      240

acatccgcag cgagacctcc gtgcccgacc atgtcgtctg gtccctgttc aacaccctct      300

tcatgaaccc ctgctgcctg ggcttcatag cattcgccta ctccgtgaag tctagggaca      360

ggaagatggt tggcgacgtg accggggccc aggcctatgc ctccaccgcc aagtgcctga      420

acatctgggc cctgattctg ggcatcctca tgaccattct gctcatcgtc atcccagtgc      480

tgatcttcca ggcctatgga tagatcagga ggcatcactg aggccaggag ctctgcccat      540

gacctgtatc ccacgtactc caacttccat tcctcgccct gcccccggag ccgagtcctg      600

tatcagccct ttatcctcac acgcttttct acaatggcat tcaataaagt gcacgtgttt      660

ctggtgctaa aaaaaaaa                                                    678


<210>  50
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Asn His Thr Val Gln Thr Phe Phe Ser Pro Val Asn Ser Gly Gln 
1               5                   10                  15      


Pro Pro Asn Tyr Glu Met Leu Lys Glu Glu His Glu Val Ala Val Leu 
            20                  25                  30          


Gly Ala Pro His Asn Pro Ala Pro Pro Thr Ser Thr Val Ile His Ile 
        35                  40                  45              


Arg Ser Glu Thr Ser Val Pro Asp His Val Val Trp Ser Leu Phe Asn 
    50                  55                  60                  


Thr Leu Phe Met Asn Pro Cys Cys Leu Gly Phe Ile Ala Phe Ala Tyr 
65                  70                  75                  80  


Ser Val Lys Ser Arg Asp Arg Lys Met Val Gly Asp Val Thr Gly Ala 
                85                  90                  95      


Gln Ala Tyr Ala Ser Thr Ala Lys Cys Leu Asn Ile Trp Ala Leu Ile 
            100                 105                 110         


Leu Gly Ile Leu Met Thr Ile Leu Leu Ile Val Ile Pro Val Leu Ile 
        115                 120                 125             


Phe Gln Ala Tyr Gly 
    130             


<210>  51
<211>  1972
<212>  DNA
<213>  Homo sapiens

<400>  51
gaaactcccg cctggccacc ataaaagcgc cggccctccg cttccccgcg agacgaaact       60

tcccgtcccg gcggctctgg cacccagggt ccggcctgcg ccttcccgcc aggcctggac      120

actggttcaa cacctgtgac ttcatgtgtg cgcgccggcc acacctgcag tcacacctgt      180

agccccctct gccaagagat ccataccgag gcagcgtcgg tggctacaag ccctcagtcc      240

acacctgtgg acacctgtga cacctggcca cacgacctgt ggccgcggcc tggcgtctgc      300

tgcgacagga gcccttacct cccctgttat aacacctgac cgccacctaa ctgcccctgc      360

agaaggagca atggccttgg ctcctgagag ggcagcccca cgcgtgctgt tcggagagtg      420

gctccttgga gagatcagca gcggctgcta tgaggggctg cagtggctgg acgaggcccg      480

cacctgtttc cgcgtgccct ggaagcactt cgcgcgcaag gacctgagcg aggccgacgc      540

gcgcatcttc aaggcctggg ctgtggcccg cggcaggtgg ccgcctagca gcaggggagg      600

tggcccgccc cccgaggctg agactgcgga gcgcgccggc tggaaaacca acttccgctg      660

cgcactgcgc agcacgcgtc gcttcgtgat gctgcgggat aactcggggg acccggccga      720

cccgcacaag gtgtacgcgc tcagccggga gctgtgctgg cgagaaggcc caggcacgga      780

ccagactgag gcagaggccc ccgcagctgt cccaccacca cagggtgggc ccccagggcc      840

attcctggca cacacacatg ctggactcca agccccaggc cccctccctg ccccagctgg      900

tgacaagggg gacctcctgc tccaggcagt gcaacagagc tgcctggcag accatctgct      960

gacagcgtca tggggggcag atccagtccc aaccaaggct cctggagagg gacaagaagg     1020

gcttcccctg actggggcct gtgctggagg cccagggctc cctgctgggg agctgtacgg     1080

gtgggcagta gagacgaccc ccagccccgg gccccagccc gcggcactaa cgacaggcga     1140

ggccgcggcc ccagagtccc cgcaccaggc agagccgtac ctgtcaccct ccccaagcgc     1200

ctgcaccgcg gtgcaagagc ccagcccagg ggcgctggac gtgaccatca tgtacaaggg     1260

ccgcacggtg ctgcagaagg tggtgggaca cccgagctgc acgttcctat acggcccccc     1320

agacccagct gtccgggcca cagaccccca gcaggtagca ttccccagcc ctgccgagct     1380

cccggaccag aagcagctgc gctacacgga ggaactgctg cggcacgtgg cccctgggtt     1440

gcacctggag cttcgggggc cacagctgtg ggcccggcgc atgggcaagt gcaaggtgta     1500

ctgggaggtg ggcggacccc caggctccgc cagcccctcc accccagcct gcctgctgcc     1560

tcggaactgt gacaccccca tcttcgactt cagagtcttc ttccaagagc tggtggaatt     1620

ccgggcacgg cagcgccgtg gctccccacg ctataccatc tacctgggct tcgggcagga     1680

cctgtcagct gggaggccca aggagaagag cctggtcctg gtgaagctgg aaccctggct     1740

gtgccgagtg cacctagagg gcacgcagcg tgagggtgtg tcttccctgg atagcagcag     1800

cctcagcctc tgcctgtcca gcgccaacag cctctatgac gacatcgagt gcttccttat     1860

ggagctggag cagcccgcct agaacccagt ctaatgagaa ctccagaaag ctggagcagc     1920

ccacctagag ctggccgcgg ccgcccagtc taataaaaag aactccagaa ca             1972


<210>  52
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ala Leu Ala Pro Glu Arg Ala Ala Pro Arg Val Leu Phe Gly Glu 
1               5                   10                  15      


Trp Leu Leu Gly Glu Ile Ser Ser Gly Cys Tyr Glu Gly Leu Gln Trp 
            20                  25                  30          


Leu Asp Glu Ala Arg Thr Cys Phe Arg Val Pro Trp Lys His Phe Ala 
        35                  40                  45              


Arg Lys Asp Leu Ser Glu Ala Asp Ala Arg Ile Phe Lys Ala Trp Ala 
    50                  55                  60                  


Val Ala Arg Gly Arg Trp Pro Pro Ser Ser Arg Gly Gly Gly Pro Pro 
65                  70                  75                  80  


Pro Glu Ala Glu Thr Ala Glu Arg Ala Gly Trp Lys Thr Asn Phe Arg 
                85                  90                  95      


Cys Ala Leu Arg Ser Thr Arg Arg Phe Val Met Leu Arg Asp Asn Ser 
            100                 105                 110         


Gly Asp Pro Ala Asp Pro His Lys Val Tyr Ala Leu Ser Arg Glu Leu 
        115                 120                 125             


Cys Trp Arg Glu Gly Pro Gly Thr Asp Gln Thr Glu Ala Glu Ala Pro 
    130                 135                 140                 


Ala Ala Val Pro Pro Pro Gln Gly Gly Pro Pro Gly Pro Phe Leu Ala 
145                 150                 155                 160 


His Thr His Ala Gly Leu Gln Ala Pro Gly Pro Leu Pro Ala Pro Ala 
                165                 170                 175     


Gly Asp Lys Gly Asp Leu Leu Leu Gln Ala Val Gln Gln Ser Cys Leu 
            180                 185                 190         


Ala Asp His Leu Leu Thr Ala Ser Trp Gly Ala Asp Pro Val Pro Thr 
        195                 200                 205             


Lys Ala Pro Gly Glu Gly Gln Glu Gly Leu Pro Leu Thr Gly Ala Cys 
    210                 215                 220                 


Ala Gly Gly Pro Gly Leu Pro Ala Gly Glu Leu Tyr Gly Trp Ala Val 
225                 230                 235                 240 


Glu Thr Thr Pro Ser Pro Gly Pro Gln Pro Ala Ala Leu Thr Thr Gly 
                245                 250                 255     


Glu Ala Ala Ala Pro Glu Ser Pro His Gln Ala Glu Pro Tyr Leu Ser 
            260                 265                 270         


Pro Ser Pro Ser Ala Cys Thr Ala Val Gln Glu Pro Ser Pro Gly Ala 
        275                 280                 285             


Leu Asp Val Thr Ile Met Tyr Lys Gly Arg Thr Val Leu Gln Lys Val 
    290                 295                 300                 


Val Gly His Pro Ser Cys Thr Phe Leu Tyr Gly Pro Pro Asp Pro Ala 
305                 310                 315                 320 


Val Arg Ala Thr Asp Pro Gln Gln Val Ala Phe Pro Ser Pro Ala Glu 
                325                 330                 335     


Leu Pro Asp Gln Lys Gln Leu Arg Tyr Thr Glu Glu Leu Leu Arg His 
            340                 345                 350         


Val Ala Pro Gly Leu His Leu Glu Leu Arg Gly Pro Gln Leu Trp Ala 
        355                 360                 365             


Arg Arg Met Gly Lys Cys Lys Val Tyr Trp Glu Val Gly Gly Pro Pro 
    370                 375                 380                 


Gly Ser Ala Ser Pro Ser Thr Pro Ala Cys Leu Leu Pro Arg Asn Cys 
385                 390                 395                 400 


Asp Thr Pro Ile Phe Asp Phe Arg Val Phe Phe Gln Glu Leu Val Glu 
                405                 410                 415     


Phe Arg Ala Arg Gln Arg Arg Gly Ser Pro Arg Tyr Thr Ile Tyr Leu 
            420                 425                 430         


Gly Phe Gly Gln Asp Leu Ser Ala Gly Arg Pro Lys Glu Lys Ser Leu 
        435                 440                 445             


Val Leu Val Lys Leu Glu Pro Trp Leu Cys Arg Val His Leu Glu Gly 
    450                 455                 460                 


Thr Gln Arg Glu Gly Val Ser Ser Leu Asp Ser Ser Ser Leu Ser Leu 
465                 470                 475                 480 


Cys Leu Ser Ser Ala Asn Ser Leu Tyr Asp Asp Ile Glu Cys Phe Leu 
                485                 490                 495     


Met Glu Leu Glu Gln Pro Ala 
            500             


<210>  53
<211>  1885
<212>  DNA
<213>  Homo sapiens

<400>  53
gaaactcccg cctggccacc ataaaagcgc cggccctccg cttccccgcg agacgaaact       60

tcccgtcccg gcggctctgg cacccagggt ccggcctgcg ccttcccgcc aggcctggac      120

actggttcaa cacctgtgac ttcatgtgtg cgcgccggcc acacctgcag tcacacctgt      180

agccccctct gccaagagat ccataccgag gcagcgtcgg tggctacaag ccctcagtcc      240

acacctgtgg acacctgtga cacctggcca cacgacctgt ggccgcggcc tggcgtctgc      300

tgcgacagga gcccttacct cccctgttat aacacctgac cgccacctaa ctgcccctgc      360

agaaggagca atggccttgg ctcctgagag ggcagcccca cgcgtgctgt tcggagagtg      420

gctccttgga gagatcagca gcggctgcta tgaggggctg cagtggctgg acgaggcccg      480

cacctgtttc cgcgtgccct ggaagcactt cgcgcgcaag gacctgagcg aggccgacgc      540

gcgcatcttc aaggcctggg ctgtggcccg cggcaggtgg ccgcctagca gcaggggagg      600

tggcccgccc cccgaggctg agactgcgga gcgcgccggc tggaaaacca acttccgctg      660

cgcactgcgc agcacgcgtc gcttcgtgat gctgcgggat aactcggggg acccggccga      720

cccgcacaag gtgtacgcgc tcagccggga gctgtgctgg cgagaaggcc caggcacgga      780

ccagactgag gcagaggccc ccgcagctgt cccaccacca cagggtgggc ccccagggcc      840

attcctggca cacacacatg ctggactcca agccccaggc cccctccctg ccccagctgg      900

tgacaagggg gacctcctgc tccaggcagt gcaacagagc tgcctggcag accatctgct      960

gacagcgtca tggggggcag atccagtccc aaccaaggct cctggagagg gacaagaagg     1020

gcttcccctg actggggcct gtgctggagg cgaggccgcg gccccagagt ccccgcacca     1080

ggcagagccg tacctgtcac cctccccaag cgcctgcacc gcggtgcaag agcccagccc     1140

aggggcgctg gacgtgacca tcatgtacaa gggccgcacg gtgctgcaga aggtggtggg     1200

acacccgagc tgcacgttcc tatacggccc cccagaccca gctgtccggg ccacagaccc     1260

ccagcaggta gcattcccca gccctgccga gctcccggac cagaagcagc tgcgctacac     1320

ggaggaactg ctgcggcacg tggcccctgg gttgcacctg gagcttcggg ggccacagct     1380

gtgggcccgg cgcatgggca agtgcaaggt gtactgggag gtgggcggac ccccaggctc     1440

cgccagcccc tccaccccag cctgcctgct gcctcggaac tgtgacaccc ccatcttcga     1500

cttcagagtc ttcttccaag agctggtgga attccgggca cggcagcgcc gtggctcccc     1560

acgctatacc atctacctgg gcttcgggca ggacctgtca gctgggaggc ccaaggagaa     1620

gagcctggtc ctggtgaagc tggaaccctg gctgtgccga gtgcacctag agggcacgca     1680

gcgtgagggt gtgtcttccc tggatagcag cagcctcagc ctctgcctgt ccagcgccaa     1740

cagcctctat gacgacatcg agtgcttcct tatggagctg gagcagcccg cctagaaccc     1800

agtctaatga gaactccaga aagctggagc agcccaccta gagctggccg cggccgccca     1860

gtctaataaa aagaactcca gaaca                                           1885


<210>  54
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Ala Leu Ala Pro Glu Arg Ala Ala Pro Arg Val Leu Phe Gly Glu 
1               5                   10                  15      


Trp Leu Leu Gly Glu Ile Ser Ser Gly Cys Tyr Glu Gly Leu Gln Trp 
            20                  25                  30          


Leu Asp Glu Ala Arg Thr Cys Phe Arg Val Pro Trp Lys His Phe Ala 
        35                  40                  45              


Arg Lys Asp Leu Ser Glu Ala Asp Ala Arg Ile Phe Lys Ala Trp Ala 
    50                  55                  60                  


Val Ala Arg Gly Arg Trp Pro Pro Ser Ser Arg Gly Gly Gly Pro Pro 
65                  70                  75                  80  


Pro Glu Ala Glu Thr Ala Glu Arg Ala Gly Trp Lys Thr Asn Phe Arg 
                85                  90                  95      


Cys Ala Leu Arg Ser Thr Arg Arg Phe Val Met Leu Arg Asp Asn Ser 
            100                 105                 110         


Gly Asp Pro Ala Asp Pro His Lys Val Tyr Ala Leu Ser Arg Glu Leu 
        115                 120                 125             


Cys Trp Arg Glu Gly Pro Gly Thr Asp Gln Thr Glu Ala Glu Ala Pro 
    130                 135                 140                 


Ala Ala Val Pro Pro Pro Gln Gly Gly Pro Pro Gly Pro Phe Leu Ala 
145                 150                 155                 160 


His Thr His Ala Gly Leu Gln Ala Pro Gly Pro Leu Pro Ala Pro Ala 
                165                 170                 175     


Gly Asp Lys Gly Asp Leu Leu Leu Gln Ala Val Gln Gln Ser Cys Leu 
            180                 185                 190         


Ala Asp His Leu Leu Thr Ala Ser Trp Gly Ala Asp Pro Val Pro Thr 
        195                 200                 205             


Lys Ala Pro Gly Glu Gly Gln Glu Gly Leu Pro Leu Thr Gly Ala Cys 
    210                 215                 220                 


Ala Gly Gly Glu Ala Ala Ala Pro Glu Ser Pro His Gln Ala Glu Pro 
225                 230                 235                 240 


Tyr Leu Ser Pro Ser Pro Ser Ala Cys Thr Ala Val Gln Glu Pro Ser 
                245                 250                 255     


Pro Gly Ala Leu Asp Val Thr Ile Met Tyr Lys Gly Arg Thr Val Leu 
            260                 265                 270         


Gln Lys Val Val Gly His Pro Ser Cys Thr Phe Leu Tyr Gly Pro Pro 
        275                 280                 285             


Asp Pro Ala Val Arg Ala Thr Asp Pro Gln Gln Val Ala Phe Pro Ser 
    290                 295                 300                 


Pro Ala Glu Leu Pro Asp Gln Lys Gln Leu Arg Tyr Thr Glu Glu Leu 
305                 310                 315                 320 


Leu Arg His Val Ala Pro Gly Leu His Leu Glu Leu Arg Gly Pro Gln 
                325                 330                 335     


Leu Trp Ala Arg Arg Met Gly Lys Cys Lys Val Tyr Trp Glu Val Gly 
            340                 345                 350         


Gly Pro Pro Gly Ser Ala Ser Pro Ser Thr Pro Ala Cys Leu Leu Pro 
        355                 360                 365             


Arg Asn Cys Asp Thr Pro Ile Phe Asp Phe Arg Val Phe Phe Gln Glu 
    370                 375                 380                 


Leu Val Glu Phe Arg Ala Arg Gln Arg Arg Gly Ser Pro Arg Tyr Thr 
385                 390                 395                 400 


Ile Tyr Leu Gly Phe Gly Gln Asp Leu Ser Ala Gly Arg Pro Lys Glu 
                405                 410                 415     


Lys Ser Leu Val Leu Val Lys Leu Glu Pro Trp Leu Cys Arg Val His 
            420                 425                 430         


Leu Glu Gly Thr Gln Arg Glu Gly Val Ser Ser Leu Asp Ser Ser Ser 
        435                 440                 445             


Leu Ser Leu Cys Leu Ser Ser Ala Asn Ser Leu Tyr Asp Asp Ile Glu 
    450                 455                 460                 


Cys Phe Leu Met Glu Leu Glu Gln Pro Ala 
465                 470                 


<210>  55
<211>  685
<212>  DNA
<213>  Homo sapiens

<400>  55
ataatagggc cggtgctgcc tgccgaagcc ggcggctgag aggcagcgaa ctcatctttg       60

ccagtacagg agcttgtgcc gtggcccaca gcccacagcc cacagccatg ggctgggacc      120

tgacggtgaa gatgctggcg ggcaacgaat tccaggtgtc cctgagcagc tccatgtcgg      180

tgtcagagct gaaggcgcag atcacccaga agatcggcgt gcacgccttc cagcagcgtc      240

tggctgtcca cccgagcggt gtggcgctgc aggacagggt cccccttgcc agccagggcc      300

tgggccccgg cagcacggtc ctgctggtgg tggacaaatg cgacgaacct ctgagcatcc      360

tggtgaggaa taacaagggc cgcagcagca cctacgaggt acggctgacg cagaccgtgg      420

cccacctgaa gcagcaagtg agcgggctgg agggtgtgca ggacgacctg ttctggctga      480

ccttcgaggg gaagcccctg gaggaccagc tcccgctggg ggagtacggc ctcaagcccc      540

tgagcaccgt gttcatgaat ctgcgcctgc ggggaggcgg cacagagcct ggcgggcgga      600

gctaagggcc tccaccagca tccgagcagg atcaagggcc ggaaataaag gctgttgtaa      660

agagaaaaaa aaaaaaaaaa aaaaa                                            685


<210>  56
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Gly Trp Asp Leu Thr Val Lys Met Leu Ala Gly Asn Glu Phe Gln 
1               5                   10                  15      


Val Ser Leu Ser Ser Ser Met Ser Val Ser Glu Leu Lys Ala Gln Ile 
            20                  25                  30          


Thr Gln Lys Ile Gly Val His Ala Phe Gln Gln Arg Leu Ala Val His 
        35                  40                  45              


Pro Ser Gly Val Ala Leu Gln Asp Arg Val Pro Leu Ala Ser Gln Gly 
    50                  55                  60                  


Leu Gly Pro Gly Ser Thr Val Leu Leu Val Val Asp Lys Cys Asp Glu 
65                  70                  75                  80  


Pro Leu Ser Ile Leu Val Arg Asn Asn Lys Gly Arg Ser Ser Thr Tyr 
                85                  90                  95      


Glu Val Arg Leu Thr Gln Thr Val Ala His Leu Lys Gln Gln Val Ser 
            100                 105                 110         


Gly Leu Glu Gly Val Gln Asp Asp Leu Phe Trp Leu Thr Phe Glu Gly 
        115                 120                 125             


Lys Pro Leu Glu Asp Gln Leu Pro Leu Gly Glu Tyr Gly Leu Lys Pro 
    130                 135                 140                 


Leu Ser Thr Val Phe Met Asn Leu Arg Leu Arg Gly Gly Gly Thr Glu 
145                 150                 155                 160 


Pro Gly Gly Arg Ser 
                165 


<210>  57
<211>  665
<212>  DNA
<213>  Homo sapiens

<400>  57
gggaacacat ccaagcttaa gacggtgagg tcagcttcac attctcagga actctccttc       60

tttgggtctg gctgaagttg aggatctctt actctctagg ccacggaatt aacccgagca      120

ggcatggagg cctctgctct cacctcatca gcagtgacca gtgtggccaa agtggtcagg      180

gtggcctctg gctctgccgt agttttgccc ctggccagga ttgctacagt tgtgattgga      240

ggagttgtgg ccatggcggc tgtgcccatg gtgctcagtg ccatgggctt cactgcggcg      300

ggaatcgcct cgtcctccat agcagccaag atgatgtccg cggcggccat tgccaatggg      360

ggtggagttg cctcgggcag ccttgtggct actctgcagt cactgggagc aactggactc      420

tccggattga ccaagttcat cctgggctcc attgggtctg ccattgcggc tgtcattgcg      480

aggttctact agctccctgc ccctcgccct gcagagaaga gaaccatgcc aggggagaag      540

gcacccagcc atcctgaccc agcgaggagc caactatccc aaatatacct ggggtgaaat      600

ataccaaatt ctgcatctcc agaggaaaat aagaaataaa gatgaattgt tgcaactctt      660

caaaa                                                                  665


<210>  58
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Glu Ala Ser Ala Leu Thr Ser Ser Ala Val Thr Ser Val Ala Lys 
1               5                   10                  15      


Val Val Arg Val Ala Ser Gly Ser Ala Val Val Leu Pro Leu Ala Arg 
            20                  25                  30          


Ile Ala Thr Val Val Ile Gly Gly Val Val Ala Met Ala Ala Val Pro 
        35                  40                  45              


Met Val Leu Ser Ala Met Gly Phe Thr Ala Ala Gly Ile Ala Ser Ser 
    50                  55                  60                  


Ser Ile Ala Ala Lys Met Met Ser Ala Ala Ala Ile Ala Asn Gly Gly 
65                  70                  75                  80  


Gly Val Ala Ser Gly Ser Leu Val Ala Thr Leu Gln Ser Leu Gly Ala 
                85                  90                  95      


Thr Gly Leu Ser Gly Leu Thr Lys Phe Ile Leu Gly Ser Ile Gly Ser 
            100                 105                 110         


Ala Ile Ala Ala Val Ile Ala Arg Phe Tyr 
        115                 120         


<210>  59
<211>  656
<212>  DNA
<213>  Homo sapiens

<400>  59
gggaacacat ccaagcttaa gacggtgagg tcagcttcac attctcagga actctccttc       60

tttgggtctg gctgaagttg aggatctctt actctctagg ccacggaatt aacccgagca      120

ggcatggagg cctctgctct cacctcatca gcagtgacca gtgtggccaa agtggtcagg      180

gtggcctctg gctctgccgt agttttgccc ctggccagga ttgctacagt tgtgattgga      240

ggagttgtgg ctgtgcccat ggtgctcagt gccatgggct tcactgcggc gggaatcgcc      300

tcgtcctcca tagcagccaa gatgatgtcc gcggcggcca ttgccaatgg gggtggagtt      360

gcctcgggca gccttgtggc tactctgcag tcactgggag caactggact ctccggattg      420

accaagttca tcctgggctc cattgggtct gccattgcgg ctgtcattgc gaggttctac      480

tagctccctg cccctcgccc tgcagagaag agaaccatgc caggggagaa ggcacccagc      540

catcctgacc cagcgaggag ccaactatcc caaatatacc tggggtgaaa tataccaaat      600

tctgcatctc cagaggaaaa taagaaataa agatgaattg ttgcaactct tcaaaa          656


<210>  60
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Glu Ala Ser Ala Leu Thr Ser Ser Ala Val Thr Ser Val Ala Lys 
1               5                   10                  15      


Val Val Arg Val Ala Ser Gly Ser Ala Val Val Leu Pro Leu Ala Arg 
            20                  25                  30          


Ile Ala Thr Val Val Ile Gly Gly Val Val Ala Val Pro Met Val Leu 
        35                  40                  45              


Ser Ala Met Gly Phe Thr Ala Ala Gly Ile Ala Ser Ser Ser Ile Ala 
    50                  55                  60                  


Ala Lys Met Met Ser Ala Ala Ala Ile Ala Asn Gly Gly Gly Val Ala 
65                  70                  75                  80  


Ser Gly Ser Leu Val Ala Thr Leu Gln Ser Leu Gly Ala Thr Gly Leu 
                85                  90                  95      


Ser Gly Leu Thr Lys Phe Ile Leu Gly Ser Ile Gly Ser Ala Ile Ala 
            100                 105                 110         


Ala Val Ile Ala Arg Phe Tyr 
        115                 


<210>  61
<211>  8040
<212>  DNA
<213>  Homo sapiens

<400>  61
ctcctccccg gcgcgctccc tgcccctcgc tccccgcagc cagcagagaa ggcggaagca       60

gtggcgtccg cagctggggc ttggcctgcg ggcggccagc gaaggtggcg aaggctccca      120

ctggatccag agtttgccgt ccaagcagcc tcgtctcggc gcgcagtgtc tgtgtccgtc      180

ctctaccagc gccttggctg agcggagtcg tgcggttggt gggggagccc tgccctcctg      240

gttcggcctc cccgcgcact agaacgatca tgaacttctg aagggaccca gctttctttg      300

tgtgctccaa gtgatttgca caaataataa tatatatatt tattgaagga gagaatcaga      360

gcaagtgata atcaagttac tatgagtctg ctaaactgtg aaaacagctg tggatccagc      420

cagtctgaaa gtgactgctg tgtggccatg gccagctcct gtagcgctgt aacaaaagat      480

gatagtgtgg gtggaactgc cagcacgggg aacctctcca gctcatttat ggaggagatc      540

cagggatatg atgtagagtt tgacccaccc ctggaaagca agtatgaatg ccccatctgc      600

ttgatggcat tacgagaagc agtgcaaacg ccatgcggcc ataggttctg caaagcctgc      660

atcataaaat caataaggga tgcaggtcac aaatgtccag ttgacaatga aatactgctg      720

gaaaatcaac tatttccaga caattttgca aaacgtgaga ttctttctct gatggtgaaa      780

tgtccaaatg aaggttgttt gcacaagatg gaactgagac atcttgagga tcatcaagca      840

cattgtgagt ttgctcttat ggattgtccc caatgccagc gtcccttcca aaaattccat      900

attaatattc acattctgaa ggattgtcca aggagacagg tttcttgtga caactgtgct      960

gcatcaatgg catttgaaga taaagagatc catgaccaga actgtccttt ggcaaatgtc     1020

atctgtgaat actgcaatac tatactcatc agagaacaga tgcctaatca ttatgatcta     1080

gactgcccta cagccccaat tccatgcaca ttcagtactt ttggttgcca tgaaaagatg     1140

cagaggaatc acttggcacg ccacctacaa gagaacaccc agtcacacat gagaatgttg     1200

gcccaggctg ttcatagttt gagcgttata cccgactctg ggtatatctc agaggtccgg     1260

aatttccagg aaactattca ccagttagag ggtcgccttg taagacaaga ccatcaaatc     1320

cgggagctga ctgctaaaat ggaaactcag agtatgtatg taagtgagct caaacgaacc     1380

attcgaaccc ttgaggacaa agttgctgaa atcgaagcac agcagtgcaa tggaatttat     1440

atttggaaga ttggcaactt tggaatgcat ttgaaatgtc aagaagagga gaaacctgtt     1500

gtgattcata gccctggatt ctacactggc aaacccgggt acaaactgtg catgcgcttg     1560

caccttcagt taccgactgc tcagcgctgt gcaaactata tatccctttt tgtccacaca     1620

atgcaaggag aatatgacag ccacctccct tggcccttcc agggtacaat acgccttaca     1680

attcttgatc agtctgaagc acctgtaagg caaaaccacg aagagataat ggatgccaaa     1740

ccagagctgc ttgctttcca gcgacccaca atcccacgga acccaaaagg ttttggctat     1800

gtaactttta tgcatctgga agccctaaga caaagaactt tcattaagga tgacacatta     1860

ttagtgcgct gtgaggtctc cacccgcttt gacatgggta gccttcggag ggagggtttt     1920

cagccacgaa gtactgatgc aggggtatag cttgccctca cttgctcaaa aacaactacc     1980

tggagaaaac agtgcctttc cttgccctgt tctcaataac atgcaaacaa acaagccacg     2040

ggaaatatgt aatatctact agtgagtgtt gttagagagg tcacttacta tttcttcctg     2100

ttacaaatga tctgaggcag ttttttcctg ggaatccaca cgttccatgc tttttcagaa     2160

atgttaggcc tgaagtgcct gtggcatgtt gcagcagcta ttttgccagt tagtatacct     2220

ctttgttgta ctttcttggg cttttgctct ggtgtatttt attgtcagaa agtccagact     2280

caagagtact aaacttttaa taataatgga ttttccttaa aacttcagtc tttttgtagt     2340

attatatgta atatattaaa agtgaaaatc actaccgcct tgtgctagtg ccctcgagaa     2400

gagttattgc tctagaaagt tgagttctca tttttttaac ctgttataga tttcagagga     2460

tttgaaccat aatccttgga aaacttaagt tctcattcac cccagttttt cctccaggtt     2520

gttactaagg atattcaggg atgagtttaa accctaaata taaccttaat tatttagtgt     2580

aaacatgtct gttgaataat acttgtttaa gtgttccttc tgccttgctt acttatttcc     2640

ttgaggttac gaagtagcat cttccccaga gtttataatg ctgagaacca cgtggatacc     2700

aactgctcat tgttatgcta tgtaaccctt tttgtctatt cagtgcagag tgaatttcac     2760

agctctgcat atgtcttcat ttgtttaatg cttacaagac aggagatgca cacatacaat     2820

cagcaacata aaaattaaaa gtgacccaag tagtcagcgc atgtggcatc tcattggtgg     2880

tgacagaagc tatgtgagcc agaagttttc agctcttttg aataccctct ggtttatttc     2940

gattaaaaag aacaaaattg atttcctaaa atcagaattt tttaaaactt gggagatgat     3000

tggagatacc taggaggtca ccaaactagg attagaagtc acagtggttg tatcacaact     3060

tagcttgagt atgttgctgt agcctaacaa ctgcaggttc tgagaaggat cctgtagaat     3120

cctggaagta accagatttt cctaataggg agatgatttt tttgtgtgcc atcatgtatt     3180

tgttaaaggc ctatatatag atataaaata tcgtggaatc tagttctcag ggagacccgc     3240

aactagtata agcttataaa ggatctaaag atccatccac catttaaagt tgtctggtaa     3300

tgagagatga cattgtatcc cccagagagg ccaaatcaga gtcgccagcc agcgttctag     3360

atcagcctta atttcaagag aaagccaagg acctcatctg caggggagtg tggttttcag     3420

ccccagcgag tgtcactttg aactttccct ttgctttttt ctctcttctc cctccccacc     3480

cacccttagg ctcctgatct ggtgagtttg ttatggagtg aaaataaaag tcaagcagag     3540

accttgtttc ccgtgccacc attagtacca caagctcatg gctagttacc acattacttc     3600

ctggcagttt gtgtccctca gctgtgcctt ccaaccagcg cctgagaatc actgcatacc     3660

accctctagg tagggaaacc tacactgctg ctgttcctgt gattatttta caatgaataa     3720

ataattgtca agttccattt aaaaactgaa cagtagtatt tttgtatttg cgtagaaaaa     3780

gcctgaagga aatatactaa actttttgtt ggcttatttt cctttgcgct tgcttatatt     3840

ttttacattt tctacaataa atgtgtactt ttatcggaga aaaaaattaa atgttgccac     3900

aaaacattta atctccacgc ccccagctca aaaaaggaaa tgatatttaa aagcttcctg     3960

gtcagatttc tattaaaagc actggctgtg cattagatac aaagaggagt catttcctgc     4020

cttggtgata ctattttttt ctactaactc aagagtcttt attaaaaaaa aaagttgttt     4080

tgcctaattt cagcttttag caagcttccc atctgtaaaa tgatttggac cagatatttc     4140

tagagtcccc tccagccata acattctgtc tcaaattaag ttccaaccag cagaacaatg     4200

acaatactta ggaaagtatt ttgccagtat aaaatgtctt taacttactc tttgctgaca     4260

ctgatacttt cctctaattt agtgtctatc agctgggtca catcttaagt aaaatgagca     4320

attttaaccc ccaacatttg gcattttgtc ataaaccagc cagttatttt atgctggtca     4380

ttcatcttga ctacaaagta gaatagtcaa gctgtcattc caaatagaaa actttttact     4440

tcaatcagaa ttaagcctta acctggaaag ttggtttctt ccttacattt tcccaatctc     4500

ctactctatt cttaaacatg ctagtttcac tcagttgggt atacaagcct ttgggcttta     4560

tgttgtatgt tactaaccac cttttaccat atttatcttt tggcatcatt ctgggacatt     4620

gctaaattaa aaaagaaatt gtttccactt ttttctggag atgttcaact aaaggttgtt     4680

ttgttttgtt ttttgttttg agacagtctc accctgacgc tcaggctgga gtgcagtggt     4740

gcaacctcgg ctcactgcaa cctccacctc ccgggctcaa gccattctcc tgcctcagcc     4800

tcccaagcag ctgggattac aggcacccgc caccacgccc agctaatttt tttgtatttt     4860

gagtagagac cgggtttcac catattggcc agtctcgtct ggaactcctg acctcagatg     4920

atccgcccgc ctcagcctcc caaagtgctg ggattacagg catgagccac cacgcccagc     4980

gtccaaccca ctgttggatg aaacttgctg cacgtcatac attttgctgt tggcaaacaa     5040

gtctgaatgt tgatttgaag tttggtagtt tattactatc tattggcagc aaagactgtt     5100

tattggtata ctacaatatg atttaacttt tattttgggg ataaatagta gaaaaaagtg     5160

aaacagaatg aaggcaggtg ttttttattc taatgatgga ataatacaga gatactggac     5220

gatctctagc agttaattat tgtgacccat ataaaattat acaggtcaca gtataattct     5280

ctattaccgt ttttacacca gtaagtctta gataaactaa gcatgcttat gaattatgta     5340

tacagttaga atgcattatt tttacagagg aacaattgct tgtatgtact aacactgttc     5400

tcttggcttg cctcaagttc tactcattat tttatataaa atactattag gctgggcacg     5460

gtggctcacg cctataatcc cagcactttg ggaggtggag gctggcggat tacttgaagc     5520

caggagttcg agaccagcct ggccaaaatg gtgaaacccc atctctataa aaatacaaaa     5580

attagccagg tgtcatgata catgcctgta atcccagctt cttgggaggc tgaggcacgg     5640

gaatcgcttg aacccgggaa gcacaggttg cagtgagcca agatcatgcc actgcacccc     5700

cagcctgggt gacagagtgc aacactgtct cacaaaacaa aacaaaaaca tcagattctg     5760

tttgtgatgc ctagttgctt acaacctaaa cagtgcaatg ccttaaggaa atgaaaagga     5820

gccataagta gtcatttata tttttatttt gaagtgtgct ttttctaaac tcccagattg     5880

acatgatgga ctgtaagtta gtttctctgt ttctgtcttt gtgcctgtag agtgtacttg     5940

gcacttacaa attcccagta tccagaaaga tgatctgatg aaatcaaatt ggatggatct     6000

tggcagactg tgacactcaa ttacagcctt cactttcagt caaaaacgga cacttggcaa     6060

ggaggtgcct ggttgtttca ctaaatgtca cttgtgtgtg taatatttta aagctttttc     6120

cccacaggaa attcgggtca taaaatcctg aaaaataatt ctaggtggga aaagcatttt     6180

aggaaatgag agatgtggtg ctgcttttct tctctcagag tgctttctca gcaggacact     6240

agccctgcct ttaagatggg gaagttgggg catgtgcctc tgctcttact gtctgcagct     6300

ctgaaggtag gtgctgtccc actcggacaa tcgcccaagc agcagtgacc atagttctct     6360

tctatgcaag tccccaggag aaggtaaact gtgtggaatg gggatgtgtt ctggttgctg     6420

ctgaatcccc tcttcttacc acagtgcctg gcacgttgca cacactcaaa tacgtaataa     6480

tgaacattta ttgaaagcag cagttgaagc tgaccaattt ctggtacctt gtcatgtaaa     6540

ttttagatgg taaggcgcag atgttacttt ttttgctttt tttcttcagc acttgatgaa     6600

atttcccaaa catgcagaaa tgttgaaaga cttgtatagt gaacatctac gacctagaat     6660

ctgcagtaat attatgttac atttgcttta tcacttgata gatgttactt ttaatgagac     6720

ttcaagtttg gtttctctaa acaaaatatt ctaaaataac tgaacaactt taatcaattt     6780

gtcttaagtt ctttggggga acttgggaca tttgctttgt aactggaatt gcagccctca     6840

cgttaagcta attttaaact ttgcaaattt gttatgctga atttcagtct tatttatttt     6900

gcctgaaggg gtattttttg taatggattt atttgaaggt ccttgataaa ttgtgcagaa     6960

tattctcgtg ttctttttgc acttgataaa ttatctaatt tctgtggtga gaatgtaatt     7020

tggggcctat tttgtttata caagcttcca gaattatgtt ctcagaggga tgaaaaggtg     7080

taatttagca tataggtcac taaattagga gctaagacac attttctcct gactgaccat     7140

gggtcaatca gttttgtctt cgtgtccttt tccttgtaaa gtagaaacta gaatttgaaa     7200

tttaaatatt aaataatggg taacattcat taatgtatga ctctattaag aaagacactg     7260

tgaatccagg gaggattctc ataattctgt aaactgtatg acaagctgtg gaatgaaatc     7320

tgacttttga aaattgaaag acatccagtg gtcttatcac aaagcctgct tttcctcaga     7380

acttaactat tgccatggaa tttgtaagca gttatcctaa tccatctgga ctctgaaaat     7440

gcatccttta tgagagggag tgaatgcaaa gataagggtg gggaaacact aatcatgaaa     7500

agaatgaaaa tcagtgttca gttttaagag caggttgtat tgaaggaagg gattaaagga     7560

attatccaga tttgaggtgg cacatcttcc accactccct gcaccatcag catgcacgga     7620

gcgcataaaa caagccctgc tcctaatggc agtgaaacct cggatggcct ccatcaggtc     7680

aatacaactg aattgctggg ctgacttaag attgaaggac tccattttag taagtagaga     7740

agtgtgacct ttctcaaccc aggttgtgaa tgtggattca cacttatctc aaaaaggcac     7800

ctggagtttt aactttatgt catgtctcag tactggttgc aaggtatgac caaaagtgtt     7860

ccttgaatgg cacctttttg aatattaatt tagaagaaaa catgccagac tgacatactt     7920

accccctccg cactgttact acttccttac cagccctatg tactgcatca atgtctacaa     7980

gaaagcactc ttcattaaaa tgaaatatat atattaaaat aaaaaaaaaa aaaaaaaaaa     8040


<210>  62
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Ser Leu Leu Asn Cys Glu Asn Ser Cys Gly Ser Ser Gln Ser Glu 
1               5                   10                  15      


Ser Asp Cys Cys Val Ala Met Ala Ser Ser Cys Ser Ala Val Thr Lys 
            20                  25                  30          


Asp Asp Ser Val Gly Gly Thr Ala Ser Thr Gly Asn Leu Ser Ser Ser 
        35                  40                  45              


Phe Met Glu Glu Ile Gln Gly Tyr Asp Val Glu Phe Asp Pro Pro Leu 
    50                  55                  60                  


Glu Ser Lys Tyr Glu Cys Pro Ile Cys Leu Met Ala Leu Arg Glu Ala 
65                  70                  75                  80  


Val Gln Thr Pro Cys Gly His Arg Phe Cys Lys Ala Cys Ile Ile Lys 
                85                  90                  95      


Ser Ile Arg Asp Ala Gly His Lys Cys Pro Val Asp Asn Glu Ile Leu 
            100                 105                 110         


Leu Glu Asn Gln Leu Phe Pro Asp Asn Phe Ala Lys Arg Glu Ile Leu 
        115                 120                 125             


Ser Leu Met Val Lys Cys Pro Asn Glu Gly Cys Leu His Lys Met Glu 
    130                 135                 140                 


Leu Arg His Leu Glu Asp His Gln Ala His Cys Glu Phe Ala Leu Met 
145                 150                 155                 160 


Asp Cys Pro Gln Cys Gln Arg Pro Phe Gln Lys Phe His Ile Asn Ile 
                165                 170                 175     


His Ile Leu Lys Asp Cys Pro Arg Arg Gln Val Ser Cys Asp Asn Cys 
            180                 185                 190         


Ala Ala Ser Met Ala Phe Glu Asp Lys Glu Ile His Asp Gln Asn Cys 
        195                 200                 205             


Pro Leu Ala Asn Val Ile Cys Glu Tyr Cys Asn Thr Ile Leu Ile Arg 
    210                 215                 220                 


Glu Gln Met Pro Asn His Tyr Asp Leu Asp Cys Pro Thr Ala Pro Ile 
225                 230                 235                 240 


Pro Cys Thr Phe Ser Thr Phe Gly Cys His Glu Lys Met Gln Arg Asn 
                245                 250                 255     


His Leu Ala Arg His Leu Gln Glu Asn Thr Gln Ser His Met Arg Met 
            260                 265                 270         


Leu Ala Gln Ala Val His Ser Leu Ser Val Ile Pro Asp Ser Gly Tyr 
        275                 280                 285             


Ile Ser Glu Val Arg Asn Phe Gln Glu Thr Ile His Gln Leu Glu Gly 
    290                 295                 300                 


Arg Leu Val Arg Gln Asp His Gln Ile Arg Glu Leu Thr Ala Lys Met 
305                 310                 315                 320 


Glu Thr Gln Ser Met Tyr Val Ser Glu Leu Lys Arg Thr Ile Arg Thr 
                325                 330                 335     


Leu Glu Asp Lys Val Ala Glu Ile Glu Ala Gln Gln Cys Asn Gly Ile 
            340                 345                 350         


Tyr Ile Trp Lys Ile Gly Asn Phe Gly Met His Leu Lys Cys Gln Glu 
        355                 360                 365             


Glu Glu Lys Pro Val Val Ile His Ser Pro Gly Phe Tyr Thr Gly Lys 
    370                 375                 380                 


Pro Gly Tyr Lys Leu Cys Met Arg Leu His Leu Gln Leu Pro Thr Ala 
385                 390                 395                 400 


Gln Arg Cys Ala Asn Tyr Ile Ser Leu Phe Val His Thr Met Gln Gly 
                405                 410                 415     


Glu Tyr Asp Ser His Leu Pro Trp Pro Phe Gln Gly Thr Ile Arg Leu 
            420                 425                 430         


Thr Ile Leu Asp Gln Ser Glu Ala Pro Val Arg Gln Asn His Glu Glu 
        435                 440                 445             


Ile Met Asp Ala Lys Pro Glu Leu Leu Ala Phe Gln Arg Pro Thr Ile 
    450                 455                 460                 


Pro Arg Asn Pro Lys Gly Phe Gly Tyr Val Thr Phe Met His Leu Glu 
465                 470                 475                 480 


Ala Leu Arg Gln Arg Thr Phe Ile Lys Asp Asp Thr Leu Leu Val Arg 
                485                 490                 495     


Cys Glu Val Ser Thr Arg Phe Asp Met Gly Ser Leu Arg Arg Glu Gly 
            500                 505                 510         


Phe Gln Pro Arg Ser Thr Asp Ala Gly Val 
        515                 520         


<210>  63
<211>  7947
<212>  DNA
<213>  Homo sapiens

<400>  63
ctcctccccg gcgcgctccc tgcccctcgc tccccgcagc cagcagagaa ggcggaagca       60

gtggcgtccg cagctggggc ttggcctgcg ggcggccagc gaaggtggcg aaggctccca      120

ctggatccag agtttgccgt ccaagcagcc tcgtctcggc gcgcagtgtc tgtgtccgtc      180

ctctaccagc gccttggctg agcggagtcg tgcggttggt gggggagccc tgccctcctg      240

gttcggcctc cccgcgcact agaacgagca agtgataatc aagttactat gagtctgcta      300

aactgtgaaa acagctgtgg atccagccag tctgaaagtg actgctgtgt ggccatggcc      360

agctcctgta gcgctgtaac aaaagatgat agtgtgggtg gaactgccag cacggggaac      420

ctctccagct catttatgga ggagatccag ggatatgatg tagagtttga cccacccctg      480

gaaagcaagt atgaatgccc catctgcttg atggcattac gagaagcagt gcaaacgcca      540

tgcggccata ggttctgcaa agcctgcatc ataaaatcaa taagggatgc aggtcacaaa      600

tgtccagttg acaatgaaat actgctggaa aatcaactat ttccagacaa ttttgcaaaa      660

cgtgagattc tttctctgat ggtgaaatgt ccaaatgaag gttgtttgca caagatggaa      720

ctgagacatc ttgaggatca tcaagcacat tgtgagtttg ctcttatgga ttgtccccaa      780

tgccagcgtc ccttccaaaa attccatatt aatattcaca ttctgaagga ttgtccaagg      840

agacaggttt cttgtgacaa ctgtgctgca tcaatggcat ttgaagataa agagatccat      900

gaccagaact gtcctttggc aaatgtcatc tgtgaatact gcaatactat actcatcaga      960

gaacagatgc ctaatcatta tgatctagac tgccctacag ccccaattcc atgcacattc     1020

agtacttttg gttgccatga aaagatgcag aggaatcact tggcacgcca cctacaagag     1080

aacacccagt cacacatgag aatgttggcc caggctgttc atagtttgag cgttataccc     1140

gactctgggt atatctcaga ggtccggaat ttccaggaaa ctattcacca gttagagggt     1200

cgccttgtaa gacaagacca tcaaatccgg gagctgactg ctaaaatgga aactcagagt     1260

atgtatgtaa gtgagctcaa acgaaccatt cgaacccttg aggacaaagt tgctgaaatc     1320

gaagcacagc agtgcaatgg aatttatatt tggaagattg gcaactttgg aatgcatttg     1380

aaatgtcaag aagaggagaa acctgttgtg attcatagcc ctggattcta cactggcaaa     1440

cccgggtaca aactgtgcat gcgcttgcac cttcagttac cgactgctca gcgctgtgca     1500

aactatatat ccctttttgt ccacacaatg caaggagaat atgacagcca cctcccttgg     1560

cccttccagg gtacaatacg ccttacaatt cttgatcagt ctgaagcacc tgtaaggcaa     1620

aaccacgaag agataatgga tgccaaacca gagctgcttg ctttccagcg acccacaatc     1680

ccacggaacc caaaaggttt tggctatgta acttttatgc atctggaagc cctaagacaa     1740

agaactttca ttaaggatga cacattatta gtgcgctgtg aggtctccac ccgctttgac     1800

atgggtagcc ttcggaggga gggttttcag ccacgaagta ctgatgcagg ggtatagctt     1860

gccctcactt gctcaaaaac aactacctgg agaaaacagt gcctttcctt gccctgttct     1920

caataacatg caaacaaaca agccacggga aatatgtaat atctactagt gagtgttgtt     1980

agagaggtca cttactattt cttcctgtta caaatgatct gaggcagttt tttcctggga     2040

atccacacgt tccatgcttt ttcagaaatg ttaggcctga agtgcctgtg gcatgttgca     2100

gcagctattt tgccagttag tatacctctt tgttgtactt tcttgggctt ttgctctggt     2160

gtattttatt gtcagaaagt ccagactcaa gagtactaaa cttttaataa taatggattt     2220

tccttaaaac ttcagtcttt ttgtagtatt atatgtaata tattaaaagt gaaaatcact     2280

accgccttgt gctagtgccc tcgagaagag ttattgctct agaaagttga gttctcattt     2340

ttttaacctg ttatagattt cagaggattt gaaccataat ccttggaaaa cttaagttct     2400

cattcacccc agtttttcct ccaggttgtt actaaggata ttcagggatg agtttaaacc     2460

ctaaatataa ccttaattat ttagtgtaaa catgtctgtt gaataatact tgtttaagtg     2520

ttccttctgc cttgcttact tatttccttg aggttacgaa gtagcatctt ccccagagtt     2580

tataatgctg agaaccacgt ggataccaac tgctcattgt tatgctatgt aacccttttt     2640

gtctattcag tgcagagtga atttcacagc tctgcatatg tcttcatttg tttaatgctt     2700

acaagacagg agatgcacac atacaatcag caacataaaa attaaaagtg acccaagtag     2760

tcagcgcatg tggcatctca ttggtggtga cagaagctat gtgagccaga agttttcagc     2820

tcttttgaat accctctggt ttatttcgat taaaaagaac aaaattgatt tcctaaaatc     2880

agaatttttt aaaacttggg agatgattgg agatacctag gaggtcacca aactaggatt     2940

agaagtcaca gtggttgtat cacaacttag cttgagtatg ttgctgtagc ctaacaactg     3000

caggttctga gaaggatcct gtagaatcct ggaagtaacc agattttcct aatagggaga     3060

tgattttttt gtgtgccatc atgtatttgt taaaggccta tatatagata taaaatatcg     3120

tggaatctag ttctcaggga gacccgcaac tagtataagc ttataaagga tctaaagatc     3180

catccaccat ttaaagttgt ctggtaatga gagatgacat tgtatccccc agagaggcca     3240

aatcagagtc gccagccagc gttctagatc agccttaatt tcaagagaaa gccaaggacc     3300

tcatctgcag gggagtgtgg ttttcagccc cagcgagtgt cactttgaac tttccctttg     3360

cttttttctc tcttctccct ccccacccac ccttaggctc ctgatctggt gagtttgtta     3420

tggagtgaaa ataaaagtca agcagagacc ttgtttcccg tgccaccatt agtaccacaa     3480

gctcatggct agttaccaca ttacttcctg gcagtttgtg tccctcagct gtgccttcca     3540

accagcgcct gagaatcact gcataccacc ctctaggtag ggaaacctac actgctgctg     3600

ttcctgtgat tattttacaa tgaataaata attgtcaagt tccatttaaa aactgaacag     3660

tagtattttt gtatttgcgt agaaaaagcc tgaaggaaat atactaaact ttttgttggc     3720

ttattttcct ttgcgcttgc ttatattttt tacattttct acaataaatg tgtactttta     3780

tcggagaaaa aaattaaatg ttgccacaaa acatttaatc tccacgcccc cagctcaaaa     3840

aaggaaatga tatttaaaag cttcctggtc agatttctat taaaagcact ggctgtgcat     3900

tagatacaaa gaggagtcat ttcctgcctt ggtgatacta tttttttcta ctaactcaag     3960

agtctttatt aaaaaaaaaa gttgttttgc ctaatttcag cttttagcaa gcttcccatc     4020

tgtaaaatga tttggaccag atatttctag agtcccctcc agccataaca ttctgtctca     4080

aattaagttc caaccagcag aacaatgaca atacttagga aagtattttg ccagtataaa     4140

atgtctttaa cttactcttt gctgacactg atactttcct ctaatttagt gtctatcagc     4200

tgggtcacat cttaagtaaa atgagcaatt ttaaccccca acatttggca ttttgtcata     4260

aaccagccag ttattttatg ctggtcattc atcttgacta caaagtagaa tagtcaagct     4320

gtcattccaa atagaaaact ttttacttca atcagaatta agccttaacc tggaaagttg     4380

gtttcttcct tacattttcc caatctccta ctctattctt aaacatgcta gtttcactca     4440

gttgggtata caagcctttg ggctttatgt tgtatgttac taaccacctt ttaccatatt     4500

tatcttttgg catcattctg ggacattgct aaattaaaaa agaaattgtt tccacttttt     4560

tctggagatg ttcaactaaa ggttgttttg ttttgttttt tgttttgaga cagtctcacc     4620

ctgacgctca ggctggagtg cagtggtgca acctcggctc actgcaacct ccacctcccg     4680

ggctcaagcc attctcctgc ctcagcctcc caagcagctg ggattacagg cacccgccac     4740

cacgcccagc taattttttt gtattttgag tagagaccgg gtttcaccat attggccagt     4800

ctcgtctgga actcctgacc tcagatgatc cgcccgcctc agcctcccaa agtgctggga     4860

ttacaggcat gagccaccac gcccagcgtc caacccactg ttggatgaaa cttgctgcac     4920

gtcatacatt ttgctgttgg caaacaagtc tgaatgttga tttgaagttt ggtagtttat     4980

tactatctat tggcagcaaa gactgtttat tggtatacta caatatgatt taacttttat     5040

tttggggata aatagtagaa aaaagtgaaa cagaatgaag gcaggtgttt tttattctaa     5100

tgatggaata atacagagat actggacgat ctctagcagt taattattgt gacccatata     5160

aaattataca ggtcacagta taattctcta ttaccgtttt tacaccagta agtcttagat     5220

aaactaagca tgcttatgaa ttatgtatac agttagaatg cattattttt acagaggaac     5280

aattgcttgt atgtactaac actgttctct tggcttgcct caagttctac tcattatttt     5340

atataaaata ctattaggct gggcacggtg gctcacgcct ataatcccag cactttggga     5400

ggtggaggct ggcggattac ttgaagccag gagttcgaga ccagcctggc caaaatggtg     5460

aaaccccatc tctataaaaa tacaaaaatt agccaggtgt catgatacat gcctgtaatc     5520

ccagcttctt gggaggctga ggcacgggaa tcgcttgaac ccgggaagca caggttgcag     5580

tgagccaaga tcatgccact gcacccccag cctgggtgac agagtgcaac actgtctcac     5640

aaaacaaaac aaaaacatca gattctgttt gtgatgccta gttgcttaca acctaaacag     5700

tgcaatgcct taaggaaatg aaaaggagcc ataagtagtc atttatattt ttattttgaa     5760

gtgtgctttt tctaaactcc cagattgaca tgatggactg taagttagtt tctctgtttc     5820

tgtctttgtg cctgtagagt gtacttggca cttacaaatt cccagtatcc agaaagatga     5880

tctgatgaaa tcaaattgga tggatcttgg cagactgtga cactcaatta cagccttcac     5940

tttcagtcaa aaacggacac ttggcaagga ggtgcctggt tgtttcacta aatgtcactt     6000

gtgtgtgtaa tattttaaag ctttttcccc acaggaaatt cgggtcataa aatcctgaaa     6060

aataattcta ggtgggaaaa gcattttagg aaatgagaga tgtggtgctg cttttcttct     6120

ctcagagtgc tttctcagca ggacactagc cctgccttta agatggggaa gttggggcat     6180

gtgcctctgc tcttactgtc tgcagctctg aaggtaggtg ctgtcccact cggacaatcg     6240

cccaagcagc agtgaccata gttctcttct atgcaagtcc ccaggagaag gtaaactgtg     6300

tggaatgggg atgtgttctg gttgctgctg aatcccctct tcttaccaca gtgcctggca     6360

cgttgcacac actcaaatac gtaataatga acatttattg aaagcagcag ttgaagctga     6420

ccaatttctg gtaccttgtc atgtaaattt tagatggtaa ggcgcagatg ttactttttt     6480

tgcttttttt cttcagcact tgatgaaatt tcccaaacat gcagaaatgt tgaaagactt     6540

gtatagtgaa catctacgac ctagaatctg cagtaatatt atgttacatt tgctttatca     6600

cttgatagat gttactttta atgagacttc aagtttggtt tctctaaaca aaatattcta     6660

aaataactga acaactttaa tcaatttgtc ttaagttctt tgggggaact tgggacattt     6720

gctttgtaac tggaattgca gccctcacgt taagctaatt ttaaactttg caaatttgtt     6780

atgctgaatt tcagtcttat ttattttgcc tgaaggggta ttttttgtaa tggatttatt     6840

tgaaggtcct tgataaattg tgcagaatat tctcgtgttc tttttgcact tgataaatta     6900

tctaatttct gtggtgagaa tgtaatttgg ggcctatttt gtttatacaa gcttccagaa     6960

ttatgttctc agagggatga aaaggtgtaa tttagcatat aggtcactaa attaggagct     7020

aagacacatt ttctcctgac tgaccatggg tcaatcagtt ttgtcttcgt gtccttttcc     7080

ttgtaaagta gaaactagaa tttgaaattt aaatattaaa taatgggtaa cattcattaa     7140

tgtatgactc tattaagaaa gacactgtga atccagggag gattctcata attctgtaaa     7200

ctgtatgaca agctgtggaa tgaaatctga cttttgaaaa ttgaaagaca tccagtggtc     7260

ttatcacaaa gcctgctttt cctcagaact taactattgc catggaattt gtaagcagtt     7320

atcctaatcc atctggactc tgaaaatgca tcctttatga gagggagtga atgcaaagat     7380

aagggtgggg aaacactaat catgaaaaga atgaaaatca gtgttcagtt ttaagagcag     7440

gttgtattga aggaagggat taaaggaatt atccagattt gaggtggcac atcttccacc     7500

actccctgca ccatcagcat gcacggagcg cataaaacaa gccctgctcc taatggcagt     7560

gaaacctcgg atggcctcca tcaggtcaat acaactgaat tgctgggctg acttaagatt     7620

gaaggactcc attttagtaa gtagagaagt gtgacctttc tcaacccagg ttgtgaatgt     7680

ggattcacac ttatctcaaa aaggcacctg gagttttaac tttatgtcat gtctcagtac     7740

tggttgcaag gtatgaccaa aagtgttcct tgaatggcac ctttttgaat attaatttag     7800

aagaaaacat gccagactga catacttacc ccctccgcac tgttactact tccttaccag     7860

ccctatgtac tgcatcaatg tctacaagaa agcactcttc attaaaatga aatatatata     7920

ttaaaataaa aaaaaaaaaa aaaaaaa                                         7947


<210>  64
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Ser Leu Leu Asn Cys Glu Asn Ser Cys Gly Ser Ser Gln Ser Glu 
1               5                   10                  15      


Ser Asp Cys Cys Val Ala Met Ala Ser Ser Cys Ser Ala Val Thr Lys 
            20                  25                  30          


Asp Asp Ser Val Gly Gly Thr Ala Ser Thr Gly Asn Leu Ser Ser Ser 
        35                  40                  45              


Phe Met Glu Glu Ile Gln Gly Tyr Asp Val Glu Phe Asp Pro Pro Leu 
    50                  55                  60                  


Glu Ser Lys Tyr Glu Cys Pro Ile Cys Leu Met Ala Leu Arg Glu Ala 
65                  70                  75                  80  


Val Gln Thr Pro Cys Gly His Arg Phe Cys Lys Ala Cys Ile Ile Lys 
                85                  90                  95      


Ser Ile Arg Asp Ala Gly His Lys Cys Pro Val Asp Asn Glu Ile Leu 
            100                 105                 110         


Leu Glu Asn Gln Leu Phe Pro Asp Asn Phe Ala Lys Arg Glu Ile Leu 
        115                 120                 125             


Ser Leu Met Val Lys Cys Pro Asn Glu Gly Cys Leu His Lys Met Glu 
    130                 135                 140                 


Leu Arg His Leu Glu Asp His Gln Ala His Cys Glu Phe Ala Leu Met 
145                 150                 155                 160 


Asp Cys Pro Gln Cys Gln Arg Pro Phe Gln Lys Phe His Ile Asn Ile 
                165                 170                 175     


His Ile Leu Lys Asp Cys Pro Arg Arg Gln Val Ser Cys Asp Asn Cys 
            180                 185                 190         


Ala Ala Ser Met Ala Phe Glu Asp Lys Glu Ile His Asp Gln Asn Cys 
        195                 200                 205             


Pro Leu Ala Asn Val Ile Cys Glu Tyr Cys Asn Thr Ile Leu Ile Arg 
    210                 215                 220                 


Glu Gln Met Pro Asn His Tyr Asp Leu Asp Cys Pro Thr Ala Pro Ile 
225                 230                 235                 240 


Pro Cys Thr Phe Ser Thr Phe Gly Cys His Glu Lys Met Gln Arg Asn 
                245                 250                 255     


His Leu Ala Arg His Leu Gln Glu Asn Thr Gln Ser His Met Arg Met 
            260                 265                 270         


Leu Ala Gln Ala Val His Ser Leu Ser Val Ile Pro Asp Ser Gly Tyr 
        275                 280                 285             


Ile Ser Glu Val Arg Asn Phe Gln Glu Thr Ile His Gln Leu Glu Gly 
    290                 295                 300                 


Arg Leu Val Arg Gln Asp His Gln Ile Arg Glu Leu Thr Ala Lys Met 
305                 310                 315                 320 


Glu Thr Gln Ser Met Tyr Val Ser Glu Leu Lys Arg Thr Ile Arg Thr 
                325                 330                 335     


Leu Glu Asp Lys Val Ala Glu Ile Glu Ala Gln Gln Cys Asn Gly Ile 
            340                 345                 350         


Tyr Ile Trp Lys Ile Gly Asn Phe Gly Met His Leu Lys Cys Gln Glu 
        355                 360                 365             


Glu Glu Lys Pro Val Val Ile His Ser Pro Gly Phe Tyr Thr Gly Lys 
    370                 375                 380                 


Pro Gly Tyr Lys Leu Cys Met Arg Leu His Leu Gln Leu Pro Thr Ala 
385                 390                 395                 400 


Gln Arg Cys Ala Asn Tyr Ile Ser Leu Phe Val His Thr Met Gln Gly 
                405                 410                 415     


Glu Tyr Asp Ser His Leu Pro Trp Pro Phe Gln Gly Thr Ile Arg Leu 
            420                 425                 430         


Thr Ile Leu Asp Gln Ser Glu Ala Pro Val Arg Gln Asn His Glu Glu 
        435                 440                 445             


Ile Met Asp Ala Lys Pro Glu Leu Leu Ala Phe Gln Arg Pro Thr Ile 
    450                 455                 460                 


Pro Arg Asn Pro Lys Gly Phe Gly Tyr Val Thr Phe Met His Leu Glu 
465                 470                 475                 480 


Ala Leu Arg Gln Arg Thr Phe Ile Lys Asp Asp Thr Leu Leu Val Arg 
                485                 490                 495     


Cys Glu Val Ser Thr Arg Phe Asp Met Gly Ser Leu Arg Arg Glu Gly 
            500                 505                 510         


Phe Gln Pro Arg Ser Thr Asp Ala Gly Val 
        515                 520         


<210>  65
<211>  1742
<212>  DNA
<213>  Homo sapiens

<400>  65
tctttgaagc ttcaaggctg ctgaataatt tccttctccc attttgtgcc tgcctagcta       60

tccagacaga gcagctaccc tcagctctag ctgatactac agacagtaca acagatcaag      120

aagtatggca gtgacaactc gtttgacatg gttgcacgaa aagatcctgc aaaatcattt      180

tggagggaag cggcttagcc ttctctataa gggtagtgtc catggattcc gtaatggagt      240

tttgcttgac agatgttgta atcaagggcc tactctaaca gtgatttata gtgaagatca      300

tattattgga gcatatgcag aagagagtta ccaggaagga aagtatgctt ccatcatcct      360

ttttgcactt caagatacta aaatttcaga atggaaacta ggactatgta caccagaaac      420

actgttttgt tgtgatgtta caaaatataa ctccccaact aatttccaga tagatggaag      480

aaatagaaaa gtgattatgg acttaaagac aatggaaaat cttggacttg ctcaaaattg      540

tactatctct attcaggatt atgaagtttt tcgatgcgaa gattcactgg atgaaagaaa      600

gataaaaggg gtcattgagc tcaggaagag cttactgtct gccttgagaa cttatgaacc      660

atatggatcc ctggttcaac aaatacgaat tctgctgctg ggtccaattg gagctgggaa      720

gtccagcttt ttcaactcag tgaggtctgt tttccaaggg catgtaacgc atcaggcttt      780

ggtgggcact aatacaactg ggatatctga gaagtatagg acatactcta ttagagacgg      840

gaaagatggc aaatacctgc cgtttattct gtgtgactca ctggggctga gtgagaaaga      900

aggcggcctg tgcagggatg acatattcta tatcttgaac ggtaacattc gtgatagata      960

ccagtttaat cccatggaat caatcaaatt aaatcatcat gactacattg attccccatc     1020

gctgaaggac agaattcatt gtgtggcatt tgtatttgat gccagctcta ttcaatactt     1080

ctcctctcag atgatagtaa agatcaaaag aattcgaagg gagttggtaa acgctggtgt     1140

ggtacatgtg gctttgctca ctcatgtgga tagcatggat ttgattacaa aaggtgacct     1200

tatagaaata gagagatgtg agcctgtgag gtccaagcta gaggaagtcc aaagaaaact     1260

tggatttgct ctttctgaca tctcggtggt tagcaattat tcctctgagt gggagctgga     1320

ccctgtaaag gatgttctaa ttctttctgc tctgagacga atgctatggg ctgcagatga     1380

cttcttagag gatttgcctt ttgagcaaat agggaatcta agggaggaaa ttatcaactg     1440

tgcacaagga aaaaaataga tatgtgaaag gttcacgtaa atttcctcac atcacagaag     1500

attaaaattc agaaaggaga aaacacagac caaagagaag tatctaagac caaagggatg     1560

tgttttatta atgtctagga tgaagaaatg catagaacat tgtagtactt gtaaataact     1620

agaaataaca tgatttagtc ataattgtga aaaataataa taatttttct tggatttatg     1680

ttctgtatct gtgaaaaaat aaatttctta taaaactcgg gtctaaaaaa aaaaaaaaaa     1740

aa                                                                    1742


<210>  66
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Ala Val Thr Thr Arg Leu Thr Trp Leu His Glu Lys Ile Leu Gln 
1               5                   10                  15      


Asn His Phe Gly Gly Lys Arg Leu Ser Leu Leu Tyr Lys Gly Ser Val 
            20                  25                  30          


His Gly Phe Arg Asn Gly Val Leu Leu Asp Arg Cys Cys Asn Gln Gly 
        35                  40                  45              


Pro Thr Leu Thr Val Ile Tyr Ser Glu Asp His Ile Ile Gly Ala Tyr 
    50                  55                  60                  


Ala Glu Glu Ser Tyr Gln Glu Gly Lys Tyr Ala Ser Ile Ile Leu Phe 
65                  70                  75                  80  


Ala Leu Gln Asp Thr Lys Ile Ser Glu Trp Lys Leu Gly Leu Cys Thr 
                85                  90                  95      


Pro Glu Thr Leu Phe Cys Cys Asp Val Thr Lys Tyr Asn Ser Pro Thr 
            100                 105                 110         


Asn Phe Gln Ile Asp Gly Arg Asn Arg Lys Val Ile Met Asp Leu Lys 
        115                 120                 125             


Thr Met Glu Asn Leu Gly Leu Ala Gln Asn Cys Thr Ile Ser Ile Gln 
    130                 135                 140                 


Asp Tyr Glu Val Phe Arg Cys Glu Asp Ser Leu Asp Glu Arg Lys Ile 
145                 150                 155                 160 


Lys Gly Val Ile Glu Leu Arg Lys Ser Leu Leu Ser Ala Leu Arg Thr 
                165                 170                 175     


Tyr Glu Pro Tyr Gly Ser Leu Val Gln Gln Ile Arg Ile Leu Leu Leu 
            180                 185                 190         


Gly Pro Ile Gly Ala Gly Lys Ser Ser Phe Phe Asn Ser Val Arg Ser 
        195                 200                 205             


Val Phe Gln Gly His Val Thr His Gln Ala Leu Val Gly Thr Asn Thr 
    210                 215                 220                 


Thr Gly Ile Ser Glu Lys Tyr Arg Thr Tyr Ser Ile Arg Asp Gly Lys 
225                 230                 235                 240 


Asp Gly Lys Tyr Leu Pro Phe Ile Leu Cys Asp Ser Leu Gly Leu Ser 
                245                 250                 255     


Glu Lys Glu Gly Gly Leu Cys Arg Asp Asp Ile Phe Tyr Ile Leu Asn 
            260                 265                 270         


Gly Asn Ile Arg Asp Arg Tyr Gln Phe Asn Pro Met Glu Ser Ile Lys 
        275                 280                 285             


Leu Asn His His Asp Tyr Ile Asp Ser Pro Ser Leu Lys Asp Arg Ile 
    290                 295                 300                 


His Cys Val Ala Phe Val Phe Asp Ala Ser Ser Ile Gln Tyr Phe Ser 
305                 310                 315                 320 


Ser Gln Met Ile Val Lys Ile Lys Arg Ile Arg Arg Glu Leu Val Asn 
                325                 330                 335     


Ala Gly Val Val His Val Ala Leu Leu Thr His Val Asp Ser Met Asp 
            340                 345                 350         


Leu Ile Thr Lys Gly Asp Leu Ile Glu Ile Glu Arg Cys Glu Pro Val 
        355                 360                 365             


Arg Ser Lys Leu Glu Glu Val Gln Arg Lys Leu Gly Phe Ala Leu Ser 
    370                 375                 380                 


Asp Ile Ser Val Val Ser Asn Tyr Ser Ser Glu Trp Glu Leu Asp Pro 
385                 390                 395                 400 


Val Lys Asp Val Leu Ile Leu Ser Ala Leu Arg Arg Met Leu Trp Ala 
                405                 410                 415     


Ala Asp Asp Phe Leu Glu Asp Leu Pro Phe Glu Gln Ile Gly Asn Leu 
            420                 425                 430         


Arg Glu Glu Ile Ile Asn Cys Ala Gln Gly Lys Lys 
        435                 440                 


<210>  67
<211>  2464
<212>  DNA
<213>  Homo sapiens

<400>  67
actttccttt cccctttcat aaaagcacag acctaacagc accctgggtg gaaacctctt       60

cagcatttgc ttggaatcag taagctaaaa acaaaatcaa ccgggacccc agcttttcag      120

aactgcaggg aaacagccat catgagtgag gtcaccaaga attccctgga gaaaatcctt      180

ccacagctga aatgccattt cacctggaac ttattcaagg aagacagtgt ctcaagggat      240

ctagaagata gagtgtgtaa ccagattgaa tttttaaaca ctgagttcaa agctacaatg      300

tacaacttgt tggcctacat aaaacaccta gatggtaaca acgaggcagc cctggaatgc      360

ttacggcaag ctgaagagtt aatccagcaa gaacatgctg accaagcaga aatcagaagt      420

ctagtcactt ggggaaacta cgcctgggtc tactatcact tgggcagact ctcagatgct      480

cagatttatg tagataaggt gaaacaaacc tgcaagaaat tttcaaatcc atacagtatt      540

gagtattctg aacttgactg tgaggaaggg tggacacaac tgaagtgtgg aagaaatgaa      600

agggcgaagg tgtgttttga gaaggctctg gaagaaaagc ccaacaaccc agaattctcc      660

tctggactgg caattgcgat gtaccatctg gataatcacc cagagaaaca gttctctact      720

gatgttttga agcaggccat tgagctgagt cctgataacc aatacgtcaa ggttctcttg      780

ggcctgaaac tgcagaagat gaataaagaa gctgaaggag agcagtttgt tgaagaagcc      840

ttggaaaagt ctccttgcca aacagatgtc ctccgcagtg cagccaaatt ttacagaaga      900

aaaggtgacc tagacaaagc tattgaactg tttcaacggg tgttggaatc cacaccaaac      960

aatggctacc tctatcacca gattgggtgc tgctacaagg caaaagtaag acaaatgcag     1020

aatacaggag aatctgaagc tagtggaaat aaagagatga ttgaagcact aaagcaatat     1080

gctatggact attcgaataa agctcttgag aagggactga atcctctgaa tgcatactcc     1140

gatctcgctg agttcctgga gacggaatgt tatcagacac cattcaataa ggaagtccct     1200

gatgctgaaa agcaacaatc ccatcagcgc tactgcaacc ttcagaaata taatgggaag     1260

tctgaagaca ctgctgtgca acatggttta gagggtttgt ccataagcaa aaaatcaact     1320

gacaaggaag agatcaaaga ccaaccacag aatgtatctg aaaatctgct tccacaaaat     1380

gcaccaaatt attggtatct tcaaggatta attcataagc agaatggaga tctgctgcaa     1440

gcagccaaat gttatgagaa ggaactgggc cgcctgctaa gggatgcccc ttcaggcata     1500

ggcagtattt tcctgtcagc atctgagctt gaggatggta gtgaggaaat gggccagggc     1560

gcagtcagct ccagtcccag agagctcctc tctaactcag agcaactgaa ctgagacaga     1620

ggaggaaaac agagcatcag aagcctgcag tggtggttgt gacgggtagg acgataggaa     1680

gacagggggc cccaacctgg gattgctgag cagggaagct ttgcatgttg ctctaaggta     1740

catttttaaa gagttgtttt ttggccgggc gcagtggctc atgcctgtaa tcccagcact     1800

ttgggaggcc gaggtgggcg gatcacgagg tctggagttt gagaccatcc tggctaacac     1860

agtgaaatcc cgtctctact aaaaatacaa aaaattagcc aggcgtggtg gctggcacct     1920

gtagtcccag ctacttggga ggctgaggca ggagaatggc gtgaacctgg aaggaagagg     1980

ttgcagtgag ccaagattgc gcccctgcac tccagcctgg gcaacagagc aagactccat     2040

ctcaaaaaaa aaaaaaaaaa aaaaaaagag ttgttttctc atgttcatta tagttcatta     2100

cagttacata gtccgaaggt cttacaacta atcactggta gcaataaatg cttcaggccc     2160

acatgatgct gattagttct cagttttcat tcagttcaca atataaccac cattcctgcc     2220

ctccctgcca agggtcataa atggtgactg cctaacaaca aaatttgcag tctcatctca     2280

ttttcatcca gacttctgga actcaaagat taacttttga ctaaccctgg aatatctctt     2340

atctcactta tagcttcagg catgtattta tatgtattct tgatagcaat accataatca     2400

atgtgtattc ctgatagtaa tgctacaata aatccaaaca tttcaactct gttaaaaaaa     2460

aaaa                                                                  2464


<210>  68
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Ser Glu Val Thr Lys Asn Ser Leu Glu Lys Ile Leu Pro Gln Leu 
1               5                   10                  15      


Lys Cys His Phe Thr Trp Asn Leu Phe Lys Glu Asp Ser Val Ser Arg 
            20                  25                  30          


Asp Leu Glu Asp Arg Val Cys Asn Gln Ile Glu Phe Leu Asn Thr Glu 
        35                  40                  45              


Phe Lys Ala Thr Met Tyr Asn Leu Leu Ala Tyr Ile Lys His Leu Asp 
    50                  55                  60                  


Gly Asn Asn Glu Ala Ala Leu Glu Cys Leu Arg Gln Ala Glu Glu Leu 
65                  70                  75                  80  


Ile Gln Gln Glu His Ala Asp Gln Ala Glu Ile Arg Ser Leu Val Thr 
                85                  90                  95      


Trp Gly Asn Tyr Ala Trp Val Tyr Tyr His Leu Gly Arg Leu Ser Asp 
            100                 105                 110         


Ala Gln Ile Tyr Val Asp Lys Val Lys Gln Thr Cys Lys Lys Phe Ser 
        115                 120                 125             


Asn Pro Tyr Ser Ile Glu Tyr Ser Glu Leu Asp Cys Glu Glu Gly Trp 
    130                 135                 140                 


Thr Gln Leu Lys Cys Gly Arg Asn Glu Arg Ala Lys Val Cys Phe Glu 
145                 150                 155                 160 


Lys Ala Leu Glu Glu Lys Pro Asn Asn Pro Glu Phe Ser Ser Gly Leu 
                165                 170                 175     


Ala Ile Ala Met Tyr His Leu Asp Asn His Pro Glu Lys Gln Phe Ser 
            180                 185                 190         


Thr Asp Val Leu Lys Gln Ala Ile Glu Leu Ser Pro Asp Asn Gln Tyr 
        195                 200                 205             


Val Lys Val Leu Leu Gly Leu Lys Leu Gln Lys Met Asn Lys Glu Ala 
    210                 215                 220                 


Glu Gly Glu Gln Phe Val Glu Glu Ala Leu Glu Lys Ser Pro Cys Gln 
225                 230                 235                 240 


Thr Asp Val Leu Arg Ser Ala Ala Lys Phe Tyr Arg Arg Lys Gly Asp 
                245                 250                 255     


Leu Asp Lys Ala Ile Glu Leu Phe Gln Arg Val Leu Glu Ser Thr Pro 
            260                 265                 270         


Asn Asn Gly Tyr Leu Tyr His Gln Ile Gly Cys Cys Tyr Lys Ala Lys 
        275                 280                 285             


Val Arg Gln Met Gln Asn Thr Gly Glu Ser Glu Ala Ser Gly Asn Lys 
    290                 295                 300                 


Glu Met Ile Glu Ala Leu Lys Gln Tyr Ala Met Asp Tyr Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Glu Lys Gly Leu Asn Pro Leu Asn Ala Tyr Ser Asp Leu Ala 
                325                 330                 335     


Glu Phe Leu Glu Thr Glu Cys Tyr Gln Thr Pro Phe Asn Lys Glu Val 
            340                 345                 350         


Pro Asp Ala Glu Lys Gln Gln Ser His Gln Arg Tyr Cys Asn Leu Gln 
        355                 360                 365             


Lys Tyr Asn Gly Lys Ser Glu Asp Thr Ala Val Gln His Gly Leu Glu 
    370                 375                 380                 


Gly Leu Ser Ile Ser Lys Lys Ser Thr Asp Lys Glu Glu Ile Lys Asp 
385                 390                 395                 400 


Gln Pro Gln Asn Val Ser Glu Asn Leu Leu Pro Gln Asn Ala Pro Asn 
                405                 410                 415     


Tyr Trp Tyr Leu Gln Gly Leu Ile His Lys Gln Asn Gly Asp Leu Leu 
            420                 425                 430         


Gln Ala Ala Lys Cys Tyr Glu Lys Glu Leu Gly Arg Leu Leu Arg Asp 
        435                 440                 445             


Ala Pro Ser Gly Ile Gly Ser Ile Phe Leu Ser Ala Ser Glu Leu Glu 
    450                 455                 460                 


Asp Gly Ser Glu Glu Met Gly Gln Gly Ala Val Ser Ser Ser Pro Arg 
465                 470                 475                 480 


Glu Leu Leu Ser Asn Ser Glu Gln Leu Asn 
                485                 490 


<210>  69
<211>  2552
<212>  DNA
<213>  Homo sapiens

<400>  69
attttcctcc tcccaacgat tttaaattag tttcactttc cagtttcctc ttccttcccc       60

taaaagcaat tactcaaaaa cggagaaaac atcagctgat gcgtgcccta ctctcccacc      120

cctttatata gttccttcag tatttacttg aggcagacag gaagacttct gaagaacaaa      180

tcagcctggt caccagcttt tcggaacagc agagacacag agggcagtca tgagtgaggt      240

caccaagaat tccctggaga aaatccttcc acagctgaaa tgccatttca cctggaactt      300

attcaaggaa gacagtgtct caagggatct agaagataga gtgtgtaacc agattgaatt      360

tttaaacact gagttcaaag ctacaatgta caacttgttg gcctacataa aacacctaga      420

tggtaacaac gaggcagccc tggaatgctt acggcaagct gaagagttaa tccagcaaga      480

acatgctgac caagcagaaa tcagaagtct agtcacttgg ggaaactacg cctgggtcta      540

ctatcacttg ggcagactct cagatgctca gatttatgta gataaggtga aacaaacctg      600

caagaaattt tcaaatccat acagtattga gtattctgaa cttgactgtg aggaagggtg      660

gacacaactg aagtgtggaa gaaatgaaag ggcgaaggtg tgttttgaga aggctctgga      720

agaaaagccc aacaacccag aattctcctc tggactggca attgcgatgt accatctgga      780

taatcaccca gagaaacagt tctctactga tgttttgaag caggccattg agctgagtcc      840

tgataaccaa tacgtcaagg ttctcttggg cctgaaactg cagaagatga ataaagaagc      900

tgaaggagag cagtttgttg aagaagcctt ggaaaagtct ccttgccaaa cagatgtcct      960

ccgcagtgca gccaaatttt acagaagaaa aggtgaccta gacaaagcta ttgaactgtt     1020

tcaacgggtg ttggaatcca caccaaacaa tggctacctc tatcaccaga ttgggtgctg     1080

ctacaaggca aaagtaagac aaatgcagaa tacaggagaa tctgaagcta gtggaaataa     1140

agagatgatt gaagcactaa agcaatatgc tatggactat tcgaataaag ctcttgagaa     1200

gggactgaat cctctgaatg catactccga tctcgctgag ttcctggaga cggaatgtta     1260

tcagacacca ttcaataagg aagtccctga tgctgaaaag caacaatccc atcagcgcta     1320

ctgcaacctt cagaaatata atgggaagtc tgaagacact gctgtgcaac atggtttaga     1380

gggtttgtcc ataagcaaaa aatcaactga caaggaagag atcaaagacc aaccacagaa     1440

tgtatctgaa aatctgcttc cacaaaatgc accaaattat tggtatcttc aaggattaat     1500

tcataagcag aatggagatc tgctgcaagc agccaaatgt tatgagaagg aactgggccg     1560

cctgctaagg gatgcccctt caggcatagg cagtattttc ctgtcagcat ctgagcttga     1620

ggatggtagt gaggaaatgg gccagggcgc agtcagctcc agtcccagag agctcctctc     1680

taactcagag caactgaact gagacagagg aggaaaacag agcatcagaa gcctgcagtg     1740

gtggttgtga cgggtaggac gataggaaga cagggggccc caacctggga ttgctgagca     1800

gggaagcttt gcatgttgct ctaaggtaca tttttaaaga gttgtttttt ggccgggcgc     1860

agtggctcat gcctgtaatc ccagcacttt gggaggccga ggtgggcgga tcacgaggtc     1920

tggagtttga gaccatcctg gctaacacag tgaaatcccg tctctactaa aaatacaaaa     1980

aattagccag gcgtggtggc tggcacctgt agtcccagct acttgggagg ctgaggcagg     2040

agaatggcgt gaacctggaa ggaagaggtt gcagtgagcc aagattgcgc ccctgcactc     2100

cagcctgggc aacagagcaa gactccatct caaaaaaaaa aaaaaaaaaa aaaaagagtt     2160

gttttctcat gttcattata gttcattaca gttacatagt ccgaaggtct tacaactaat     2220

cactggtagc aataaatgct tcaggcccac atgatgctga ttagttctca gttttcattc     2280

agttcacaat ataaccacca ttcctgccct ccctgccaag ggtcataaat ggtgactgcc     2340

taacaacaaa atttgcagtc tcatctcatt ttcatccaga cttctggaac tcaaagatta     2400

acttttgact aaccctggaa tatctcttat ctcacttata gcttcaggca tgtatttata     2460

tgtattcttg atagcaatac cataatcaat gtgtattcct gatagtaatg ctacaataaa     2520

tccaaacatt tcaactctgt taaaaaaaaa aa                                   2552


<210>  70
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Ser Glu Val Thr Lys Asn Ser Leu Glu Lys Ile Leu Pro Gln Leu 
1               5                   10                  15      


Lys Cys His Phe Thr Trp Asn Leu Phe Lys Glu Asp Ser Val Ser Arg 
            20                  25                  30          


Asp Leu Glu Asp Arg Val Cys Asn Gln Ile Glu Phe Leu Asn Thr Glu 
        35                  40                  45              


Phe Lys Ala Thr Met Tyr Asn Leu Leu Ala Tyr Ile Lys His Leu Asp 
    50                  55                  60                  


Gly Asn Asn Glu Ala Ala Leu Glu Cys Leu Arg Gln Ala Glu Glu Leu 
65                  70                  75                  80  


Ile Gln Gln Glu His Ala Asp Gln Ala Glu Ile Arg Ser Leu Val Thr 
                85                  90                  95      


Trp Gly Asn Tyr Ala Trp Val Tyr Tyr His Leu Gly Arg Leu Ser Asp 
            100                 105                 110         


Ala Gln Ile Tyr Val Asp Lys Val Lys Gln Thr Cys Lys Lys Phe Ser 
        115                 120                 125             


Asn Pro Tyr Ser Ile Glu Tyr Ser Glu Leu Asp Cys Glu Glu Gly Trp 
    130                 135                 140                 


Thr Gln Leu Lys Cys Gly Arg Asn Glu Arg Ala Lys Val Cys Phe Glu 
145                 150                 155                 160 


Lys Ala Leu Glu Glu Lys Pro Asn Asn Pro Glu Phe Ser Ser Gly Leu 
                165                 170                 175     


Ala Ile Ala Met Tyr His Leu Asp Asn His Pro Glu Lys Gln Phe Ser 
            180                 185                 190         


Thr Asp Val Leu Lys Gln Ala Ile Glu Leu Ser Pro Asp Asn Gln Tyr 
        195                 200                 205             


Val Lys Val Leu Leu Gly Leu Lys Leu Gln Lys Met Asn Lys Glu Ala 
    210                 215                 220                 


Glu Gly Glu Gln Phe Val Glu Glu Ala Leu Glu Lys Ser Pro Cys Gln 
225                 230                 235                 240 


Thr Asp Val Leu Arg Ser Ala Ala Lys Phe Tyr Arg Arg Lys Gly Asp 
                245                 250                 255     


Leu Asp Lys Ala Ile Glu Leu Phe Gln Arg Val Leu Glu Ser Thr Pro 
            260                 265                 270         


Asn Asn Gly Tyr Leu Tyr His Gln Ile Gly Cys Cys Tyr Lys Ala Lys 
        275                 280                 285             


Val Arg Gln Met Gln Asn Thr Gly Glu Ser Glu Ala Ser Gly Asn Lys 
    290                 295                 300                 


Glu Met Ile Glu Ala Leu Lys Gln Tyr Ala Met Asp Tyr Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Glu Lys Gly Leu Asn Pro Leu Asn Ala Tyr Ser Asp Leu Ala 
                325                 330                 335     


Glu Phe Leu Glu Thr Glu Cys Tyr Gln Thr Pro Phe Asn Lys Glu Val 
            340                 345                 350         


Pro Asp Ala Glu Lys Gln Gln Ser His Gln Arg Tyr Cys Asn Leu Gln 
        355                 360                 365             


Lys Tyr Asn Gly Lys Ser Glu Asp Thr Ala Val Gln His Gly Leu Glu 
    370                 375                 380                 


Gly Leu Ser Ile Ser Lys Lys Ser Thr Asp Lys Glu Glu Ile Lys Asp 
385                 390                 395                 400 


Gln Pro Gln Asn Val Ser Glu Asn Leu Leu Pro Gln Asn Ala Pro Asn 
                405                 410                 415     


Tyr Trp Tyr Leu Gln Gly Leu Ile His Lys Gln Asn Gly Asp Leu Leu 
            420                 425                 430         


Gln Ala Ala Lys Cys Tyr Glu Lys Glu Leu Gly Arg Leu Leu Arg Asp 
        435                 440                 445             


Ala Pro Ser Gly Ile Gly Ser Ile Phe Leu Ser Ala Ser Glu Leu Glu 
    450                 455                 460                 


Asp Gly Ser Glu Glu Met Gly Gln Gly Ala Val Ser Ser Ser Pro Arg 
465                 470                 475                 480 


Glu Leu Leu Ser Asn Ser Glu Gln Leu Asn 
                485                 490 


<210>  71
<211>  2103
<212>  DNA
<213>  Homo sapiens

<400>  71
tgactagacg gccagcctgt taaggtggcc ccagatattc cagcctcagc ccagagtcct       60

cctgtgcccc tactgcagca agggtgtctc caagaagggg gacctggagt cagcccgtca      120

cacctggttt cctctctgct agggtccctc ctcccacaga gcactggagg gcagctgagg      180

aggagctacc ttaaaaaagg aggtgtgtgc cagggagctg ggtaggagcc tggctatata      240

tctgcccagc agcggtactc tcgggacaga gatggcactg atgcaggaac tgtatagcac      300

accagcctcc aggctggact ccttcgtggc tcagtggctg cagccccacc gggagtggaa      360

ggaagaggtg ctagacgctg tgcggaccgt ggaggagttt ctgaggcagg agcatttcca      420

ggggaagcgt gggctggacc aggatgtgcg ggtgctgaag gtagtcaagg tgggctcctt      480

cgggaatggc acggttctca ggagcaccag agaggtggag ctggtggcgt ttctgagctg      540

tttccacagc ttccaggagg cagccaagca tcacaaagat gttctgaggc tgatatggaa      600

aaccatgtgg caaagccagg acctgctgga cctcgggctc gaggacctga ggatggagca      660

gagagtcccc gatgctctcg tcttcaccat ccagaccagg gggactgcgg agcccatcac      720

ggtcaccatt gtgcctgcct acagagccct ggggccttct cttcccaact cccagccacc      780

ccctgaggtc tatgtgagcc tgatcaaggc ctgcggtggt cctggaaatt tctgcccatc      840

cttcagcgag ctgcagagaa atttcgtgaa acatcggcca actaagctga agagcctcct      900

gcgcctggtg aaacactggt accagcagta tgtgaaagcc aggtccccca gagccaatct      960

gccccctctc tatgctcttg aacttctaac catctatgcc tgggaaatgg gtactgaaga     1020

agacgagaat ttcatgttgg acgaaggctt caccactgtg atggacctgc tcctggagta     1080

tgaagtcatc tgtatctact ggaccaagta ctacacactc cacaatgcaa tcattgagga     1140

ttgtgtcaga aaacagctca aaaaagagag gcccatcatc ctggatccgg ccgaccccac     1200

cctcaacgtg gcagaagggt acagatggga catcgttgct cagagggcct cccagtgcct     1260

gaaacaggac tgttgctatg acaacaggga gaaccccatc tccagctgga acgtgaagag     1320

ggcacgagac atccacttga cagtggagca gaggggttac ccagatttca acctcatcgt     1380

gaacccttat gagcccataa ggaaggttaa agagaaaatc cggaggacca ggggctactc     1440

tggcctgcag cgtctgtcct tccaggttcc tggcagtgag aggcagcttc tcagcagcag     1500

gtgctcctta gccaaatatg ggatcttctc ccacactcac atctatctgc tggagaccat     1560

cccctccgag atccaggtct tcgtgaagaa tcctgatggt gggagctacg cctatgccat     1620

caaccccaac agcttcatcc tgggtctgaa gcagcagatt gaagaccagc aggggcttcc     1680

taaaaagcag cagcagctgg aattccaagg ccaagtcctg caggactggt tgggtctggg     1740

gatctatggc atccaagaca gtgacactct catcctctcg aagaagaaag gagaggctct     1800

gtttccagcc agttagtttt ctctgggaga cttctctgta catttctgcc atgtactcca     1860

gaactcatcc tgtcaatcac tctgtcccat tgtctactgg gaaggtccca ggtcttcacc     1920

agttttacaa tgagttatcc caggccagac gtggtagctc acacctgtaa tcccagaact     1980

ttgggaggcc gaggtgggag gagcgcttga gccgaggagt tcaagaccag cctgggtatc     2040

acagggagac cccgtctcta caaaataaaa aaataattca ctgggaaaaa aaaaaaaaaa     2100

aaa                                                                   2103


<210>  72
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Ala Leu Met Gln Glu Leu Tyr Ser Thr Pro Ala Ser Arg Leu Asp 
1               5                   10                  15      


Ser Phe Val Ala Gln Trp Leu Gln Pro His Arg Glu Trp Lys Glu Glu 
            20                  25                  30          


Val Leu Asp Ala Val Arg Thr Val Glu Glu Phe Leu Arg Gln Glu His 
        35                  40                  45              


Phe Gln Gly Lys Arg Gly Leu Asp Gln Asp Val Arg Val Leu Lys Val 
    50                  55                  60                  


Val Lys Val Gly Ser Phe Gly Asn Gly Thr Val Leu Arg Ser Thr Arg 
65                  70                  75                  80  


Glu Val Glu Leu Val Ala Phe Leu Ser Cys Phe His Ser Phe Gln Glu 
                85                  90                  95      


Ala Ala Lys His His Lys Asp Val Leu Arg Leu Ile Trp Lys Thr Met 
            100                 105                 110         


Trp Gln Ser Gln Asp Leu Leu Asp Leu Gly Leu Glu Asp Leu Arg Met 
        115                 120                 125             


Glu Gln Arg Val Pro Asp Ala Leu Val Phe Thr Ile Gln Thr Arg Gly 
    130                 135                 140                 


Thr Ala Glu Pro Ile Thr Val Thr Ile Val Pro Ala Tyr Arg Ala Leu 
145                 150                 155                 160 


Gly Pro Ser Leu Pro Asn Ser Gln Pro Pro Pro Glu Val Tyr Val Ser 
                165                 170                 175     


Leu Ile Lys Ala Cys Gly Gly Pro Gly Asn Phe Cys Pro Ser Phe Ser 
            180                 185                 190         


Glu Leu Gln Arg Asn Phe Val Lys His Arg Pro Thr Lys Leu Lys Ser 
        195                 200                 205             


Leu Leu Arg Leu Val Lys His Trp Tyr Gln Gln Tyr Val Lys Ala Arg 
    210                 215                 220                 


Ser Pro Arg Ala Asn Leu Pro Pro Leu Tyr Ala Leu Glu Leu Leu Thr 
225                 230                 235                 240 


Ile Tyr Ala Trp Glu Met Gly Thr Glu Glu Asp Glu Asn Phe Met Leu 
                245                 250                 255     


Asp Glu Gly Phe Thr Thr Val Met Asp Leu Leu Leu Glu Tyr Glu Val 
            260                 265                 270         


Ile Cys Ile Tyr Trp Thr Lys Tyr Tyr Thr Leu His Asn Ala Ile Ile 
        275                 280                 285             


Glu Asp Cys Val Arg Lys Gln Leu Lys Lys Glu Arg Pro Ile Ile Leu 
    290                 295                 300                 


Asp Pro Ala Asp Pro Thr Leu Asn Val Ala Glu Gly Tyr Arg Trp Asp 
305                 310                 315                 320 


Ile Val Ala Gln Arg Ala Ser Gln Cys Leu Lys Gln Asp Cys Cys Tyr 
                325                 330                 335     


Asp Asn Arg Glu Asn Pro Ile Ser Ser Trp Asn Val Lys Arg Ala Arg 
            340                 345                 350         


Asp Ile His Leu Thr Val Glu Gln Arg Gly Tyr Pro Asp Phe Asn Leu 
        355                 360                 365             


Ile Val Asn Pro Tyr Glu Pro Ile Arg Lys Val Lys Glu Lys Ile Arg 
    370                 375                 380                 


Arg Thr Arg Gly Tyr Ser Gly Leu Gln Arg Leu Ser Phe Gln Val Pro 
385                 390                 395                 400 


Gly Ser Glu Arg Gln Leu Leu Ser Ser Arg Cys Ser Leu Ala Lys Tyr 
                405                 410                 415     


Gly Ile Phe Ser His Thr His Ile Tyr Leu Leu Glu Thr Ile Pro Ser 
            420                 425                 430         


Glu Ile Gln Val Phe Val Lys Asn Pro Asp Gly Gly Ser Tyr Ala Tyr 
        435                 440                 445             


Ala Ile Asn Pro Asn Ser Phe Ile Leu Gly Leu Lys Gln Gln Ile Glu 
    450                 455                 460                 


Asp Gln Gln Gly Leu Pro Lys Lys Gln Gln Gln Leu Glu Phe Gln Gly 
465                 470                 475                 480 


Gln Val Leu Gln Asp Trp Leu Gly Leu Gly Ile Tyr Gly Ile Gln Asp 
                485                 490                 495     


Ser Asp Thr Leu Ile Leu Ser Lys Lys Lys Gly Glu Ala Leu Phe Pro 
            500                 505                 510         


Ala Ser 
        


<210>  73
<211>  1861
<212>  DNA
<213>  Homo sapiens

<400>  73
tgactagacg gccagcctgt taaggtggcc ccagatattc cagcctcagc ccagagtcct       60

cctgtgcccc tactgcagca agggtgtctc caagaagggg gacctggagt cagcccgtca      120

cacctggttt cctctctgct agggtccctc ctcccacaga gcactggagg gcagctgagg      180

aggagctacc ttaaaaaagg aggtgtgtgc cagggagctg ggtaggagcc tggctatata      240

tctgcccagc agcggtactc tcgggacaga gatggcactg atgcaggaac tgtatagcac      300

accagcctcc aggctggact ccttcgtggc tcagtggctg cagccccacc gggagtggaa      360

ggaagaggtg ctagacgctg tgcggaccgt ggaggagttt ctgaggcagg agcatttcca      420

ggggaagcgt gggctggacc aggatgtgcg ggtgctgaag gtagtcaagg tgggctcctt      480

cgggaatggc acggttctca ggagcaccag agaggtggag ctggtggcgt ttctgagctg      540

tttccacagc ttccaggagg cagccaagca tcacaaagat gttctgaggc tgatatggaa      600

aaccatgtgg caaagccagg acctgctgga cctcgggctc gaggacctga ggatggagca      660

gagagtcccc gatgctctcg tcttcaccat ccagaccagg gggactgcgg agcccatcac      720

ggtcaccatt gtgcctgcct acagagccct ggggccttct cttcccaact cccagccacc      780

ccctgaggtc tatgtgagcc tgatcaaggc ctgcggtggt cctggaaatt tctgcccatc      840

cttcagcgag ctgcagagaa atttcgtgaa acatcggcca actaagctga agagcctcct      900

gcgcctggtg aaacactggt accagcaggc ccatcatcct ggatccggcc gaccccaccc      960

tcaacgtggc agaagggtac agatgggaca tcgttgctca gagggcctcc cagtgcctga     1020

aacaggactg ttgctatgac aacagggaga accccatctc cagctggaac gtgaagaggg     1080

cacgagacat ccacttgaca gtggagcaga ggggttaccc agatttcaac ctcatcgtga     1140

acccttatga gcccataagg aaggttaaag agaaaatccg gaggaccagg ggctactctg     1200

gcctgcagcg tctgtccttc caggttcctg gcagtgagag gcagcttctc agcagcaggt     1260

gctccttagc caaatatggg atcttctccc acactcacat ctatctgctg gagaccatcc     1320

cctccgagat ccaggtcttc gtgaagaatc ctgatggtgg gagctacgcc tatgccatca     1380

accccaacag cttcatcctg ggtctgaagc agcagattga agaccagcag gggcttccta     1440

aaaagcagca gcagctggaa ttccaaggcc aagtcctgca ggactggttg ggtctgggga     1500

tctatggcat ccaagacagt gacactctca tcctctcgaa gaagaaagga gaggctctgt     1560

ttccagccag ttagttttct ctgggagact tctctgtaca tttctgccat gtactccaga     1620

actcatcctg tcaatcactc tgtcccattg tctactggga aggtcccagg tcttcaccag     1680

ttttacaatg agttatccca ggccagacgt ggtagctcac acctgtaatc ccagaacttt     1740

gggaggccga ggtgggagga gcgcttgagc cgaggagttc aagaccagcc tgggtatcac     1800

agggagaccc cgtctctaca aaataaaaaa ataattcact gggaaaaaaa aaaaaaaaaa     1860

a                                                                     1861


<210>  74
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Ala Leu Met Gln Glu Leu Tyr Ser Thr Pro Ala Ser Arg Leu Asp 
1               5                   10                  15      


Ser Phe Val Ala Gln Trp Leu Gln Pro His Arg Glu Trp Lys Glu Glu 
            20                  25                  30          


Val Leu Asp Ala Val Arg Thr Val Glu Glu Phe Leu Arg Gln Glu His 
        35                  40                  45              


Phe Gln Gly Lys Arg Gly Leu Asp Gln Asp Val Arg Val Leu Lys Val 
    50                  55                  60                  


Val Lys Val Gly Ser Phe Gly Asn Gly Thr Val Leu Arg Ser Thr Arg 
65                  70                  75                  80  


Glu Val Glu Leu Val Ala Phe Leu Ser Cys Phe His Ser Phe Gln Glu 
                85                  90                  95      


Ala Ala Lys His His Lys Asp Val Leu Arg Leu Ile Trp Lys Thr Met 
            100                 105                 110         


Trp Gln Ser Gln Asp Leu Leu Asp Leu Gly Leu Glu Asp Leu Arg Met 
        115                 120                 125             


Glu Gln Arg Val Pro Asp Ala Leu Val Phe Thr Ile Gln Thr Arg Gly 
    130                 135                 140                 


Thr Ala Glu Pro Ile Thr Val Thr Ile Val Pro Ala Tyr Arg Ala Leu 
145                 150                 155                 160 


Gly Pro Ser Leu Pro Asn Ser Gln Pro Pro Pro Glu Val Tyr Val Ser 
                165                 170                 175     


Leu Ile Lys Ala Cys Gly Gly Pro Gly Asn Phe Cys Pro Ser Phe Ser 
            180                 185                 190         


Glu Leu Gln Arg Asn Phe Val Lys His Arg Pro Thr Lys Leu Lys Ser 
        195                 200                 205             


Leu Leu Arg Leu Val Lys His Trp Tyr Gln Gln Ala His His Pro Gly 
    210                 215                 220                 


Ser Gly Arg Pro His Pro Gln Arg Gly Arg Arg Val Gln Met Gly His 
225                 230                 235                 240 


Arg Cys Ser Glu Gly Leu Pro Val Pro Glu Thr Gly Leu Leu Leu 
                245                 250                 255 


<210>  75
<211>  3099
<212>  DNA
<213>  Homo sapiens

<400>  75
aaatattctt gcttgagtaa accacagtaa gaataaggaa gtagtgactg agtgccttgc       60

cagtacagca gatgctagaa cataatgtag cattactttc cccagggttt attgttatgt      120

aagttcttgt tcagcttcct ttgttttctt tcacttctga gaatttaact ttcgtttctc      180

actcagctcc tgtggggaaa ctcatttgtg gagaccagcc ctctggcttg gtgagtgaat      240

ctggtttaca ccggctcctg ccctgccttc actcttctcc cctgattcaa gactcctctg      300

ctttggactg aagcactgca ggagtttgtg accaagaact tcaagagtca agacagaagg      360

aagccaaggg agcagtgcaa tggatttctc agtaaaggta gacatagaga aggaggtgac      420

ctgccccatc tgcctggagc tcctgacaga acctctgagc ctagattgtg gccacagctt      480

ctgccaagcc tgcatcactg caaagatcaa ggagtcagtg atcatctcaa gaggggaaag      540

cagctgtcct gtgtgtcaga ccagattcca gcctgggaac ctccgaccta atcggcatct      600

ggccaacata gttgagagag tcaaagaggt caagatgagc ccacaggagg ggcagaagag      660

agatgtctgt gagcaccatg gaaaaaaact ccagatcttc tgtaaggagg atggaaaagt      720

catttgctgg gtttgtgaac tgtctcagga acaccaaggt caccaaacat tccgcataaa      780

cgaggtggtc aaggaatgtc aggaaaagct gcaggtagcc ctgcagaggc tgataaagga      840

ggatcaagag gctgagaagc tggaagatga catcagacaa gagagaaccg cctggaagat      900

cgagagacag aagattctga aagggttcaa tgaaatgaga gtcatcttgg acaatgagga      960

gcagagagag ctgcaaaagc tggaggaagg tgaggtgaat gtgctggata acctggcagc     1020

agctacagac cagctggtcc agcagaggca ggatgccagc acgctcatct cagatctcca     1080

gcggaggttg aggggatcgt cagtagagat gctgcaggat gtgattgacg tcatgaaaag     1140

gagtgaaagc tggacattga agaagccaaa atctgtttcc aagaaactaa agagtgtatt     1200

ccgagtacca gatctgagtg ggatgctgca agttcttaaa gagctgacag atgtccagta     1260

ctactgggtg gacgtgatgc tgaatccagg cagtgccact tcgaatgttg ctatttctgt     1320

ggatcagaga caagtgaaaa ctgtacgcac ctgcacattt aagaattcaa atccatgtga     1380

tttttctgct tttggtgtct tcggctgcca atatttctct tcggggaaat attactggga     1440

agtagatgtg tctggaaaga ttgcctggat cctgggcgta cacagtaaaa taagtagtct     1500

gaataaaagg aagagctctg ggtttgcttt tgatccaagt gtaaattatt caaaagttta     1560

ctccagatat agacctcaat atggctactg ggttatagga ttacagaata catgtgaata     1620

taatgctttt gaggactcct cctcttctga tcccaaggtt ttgactctct ttatggctgt     1680

gcctccctgt cgtattgggg ttttcctaga ctatgaggca ggcattgtct catttttcaa     1740

tgtcacaaac cacggagcac tcatctacaa gttctctgga tgtcgctttt ctcgacctgc     1800

ttatccgtat ttcaatcctt ggaactgcct agtccccatg actgtgtgcc caccgagctc     1860

ctgagtgttc tcattccttt acccacttct gcatagtagc ccttgtgctg agactcagat     1920

tctgcacctg agttcatctc tactgagacc atctcttcct ttctttcccc ttcttttact     1980

tagaatgtct ttgtattcat ttgctagggc ttccatagca aagcatcata gattgctgat     2040

ttaaactgta attgtattgc cgtactgtgg gctggaaatc ccaaatctag attccagcag     2100

agttggttct ttctgaggtc tgcaaggaag ggctctgttc catgcctctc tccttggctt     2160

gtagaaggca tcttgtccct atgactcttc acattgtctt tatgtacatc tctgtgccca     2220

agttttccct ttttattaag acaccagtca tactggctca gggcccaccg ctaatgcctt     2280

aatgaaatca ttttaacatt atattctcta caaagacctt atttccaaat aagataatat     2340

ttggaggtat tgggaataaa aactccaaca tataaatttg aggaaggcac gatttcactc     2400

ataacaatct taccctttct tgcaagagat gcttgtacat tattttccta ataccttggt     2460

ttcactagta gtaaacatta ttattttttt tatatttgca aaggaaacat atctaatcct     2520

tcctatagaa agaacagtat tgctgtaatt ccttttcttt tcttcctcat ttcctctgcc     2580

ccttaaaaga ttgaagaaag agaaacttgt caactcatat ccacgttatc tagcaaagta     2640

cataagaatc tatcactaag taatgtatcc ttcagaatgt gttggtttac cagtgacacc     2700

ccatattcat cacaaaatta aagcaagaag tccatagtaa tttatttgct aatagtggat     2760

ttttaatgct cagagtttct gaggtcaaat tttatctttt cacttacaag ctctatgatc     2820

ttaaataatt tacttaatgt attttggtgt attttcctca aattaatatt ggtgttcaag     2880

actatatcta attcctctga tcactttgag aaacaaactt ttattaaatg taaggcactt     2940

ttctatgaat tttaaatata aaaataaata ttgttctgat tattactgaa aagatgtcag     3000

ccatttcaat gtcttgggaa acaatttttt gtttttgttc tgttttcttt ttgcttcaat     3060

aaaacaatag ctggctctaa aaaaaaaaaa aaaaaaaaa                            3099


<210>  76
<211>  494
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Asp Phe Ser Val Lys Val Asp Ile Glu Lys Glu Val Thr Cys Pro 
1               5                   10                  15      


Ile Cys Leu Glu Leu Leu Thr Glu Pro Leu Ser Leu Asp Cys Gly His 
            20                  25                  30          


Ser Phe Cys Gln Ala Cys Ile Thr Ala Lys Ile Lys Glu Ser Val Ile 
        35                  40                  45              


Ile Ser Arg Gly Glu Ser Ser Cys Pro Val Cys Gln Thr Arg Phe Gln 
    50                  55                  60                  


Pro Gly Asn Leu Arg Pro Asn Arg His Leu Ala Asn Ile Val Glu Arg 
65                  70                  75                  80  


Val Lys Glu Val Lys Met Ser Pro Gln Glu Gly Gln Lys Arg Asp Val 
                85                  90                  95      


Cys Glu His His Gly Lys Lys Leu Gln Ile Phe Cys Lys Glu Asp Gly 
            100                 105                 110         


Lys Val Ile Cys Trp Val Cys Glu Leu Ser Gln Glu His Gln Gly His 
        115                 120                 125             


Gln Thr Phe Arg Ile Asn Glu Val Val Lys Glu Cys Gln Glu Lys Leu 
    130                 135                 140                 


Gln Val Ala Leu Gln Arg Leu Ile Lys Glu Asp Gln Glu Ala Glu Lys 
145                 150                 155                 160 


Leu Glu Asp Asp Ile Arg Gln Glu Arg Thr Ala Trp Lys Ile Glu Arg 
                165                 170                 175     


Gln Lys Ile Leu Lys Gly Phe Asn Glu Met Arg Val Ile Leu Asp Asn 
            180                 185                 190         


Glu Glu Gln Arg Glu Leu Gln Lys Leu Glu Glu Gly Glu Val Asn Val 
        195                 200                 205             


Leu Asp Asn Leu Ala Ala Ala Thr Asp Gln Leu Val Gln Gln Arg Gln 
    210                 215                 220                 


Asp Ala Ser Thr Leu Ile Ser Asp Leu Gln Arg Arg Leu Arg Gly Ser 
225                 230                 235                 240 


Ser Val Glu Met Leu Gln Asp Val Ile Asp Val Met Lys Arg Ser Glu 
                245                 250                 255     


Ser Trp Thr Leu Lys Lys Pro Lys Ser Val Ser Lys Lys Leu Lys Ser 
            260                 265                 270         


Val Phe Arg Val Pro Asp Leu Ser Gly Met Leu Gln Val Leu Lys Glu 
        275                 280                 285             


Leu Thr Asp Val Gln Tyr Tyr Trp Val Asp Val Met Leu Asn Pro Gly 
    290                 295                 300                 


Ser Ala Thr Ser Asn Val Ala Ile Ser Val Asp Gln Arg Gln Val Lys 
305                 310                 315                 320 


Thr Val Arg Thr Cys Thr Phe Lys Asn Ser Asn Pro Cys Asp Phe Ser 
                325                 330                 335     


Ala Phe Gly Val Phe Gly Cys Gln Tyr Phe Ser Ser Gly Lys Tyr Tyr 
            340                 345                 350         


Trp Glu Val Asp Val Ser Gly Lys Ile Ala Trp Ile Leu Gly Val His 
        355                 360                 365             


Ser Lys Ile Ser Ser Leu Asn Lys Arg Lys Ser Ser Gly Phe Ala Phe 
    370                 375                 380                 


Asp Pro Ser Val Asn Tyr Ser Lys Val Tyr Ser Arg Tyr Arg Pro Gln 
385                 390                 395                 400 


Tyr Gly Tyr Trp Val Ile Gly Leu Gln Asn Thr Cys Glu Tyr Asn Ala 
                405                 410                 415     


Phe Glu Asp Ser Ser Ser Ser Asp Pro Lys Val Leu Thr Leu Phe Met 
            420                 425                 430         


Ala Val Pro Pro Cys Arg Ile Gly Val Phe Leu Asp Tyr Glu Ala Gly 
        435                 440                 445             


Ile Val Ser Phe Phe Asn Val Thr Asn His Gly Ala Leu Ile Tyr Lys 
    450                 455                 460                 


Phe Ser Gly Cys Arg Phe Ser Arg Pro Ala Tyr Pro Tyr Phe Asn Pro 
465                 470                 475                 480 


Trp Asn Cys Leu Val Pro Met Thr Val Cys Pro Pro Ser Ser 
                485                 490                 


<210>  77
<211>  3111
<212>  DNA
<213>  Homo sapiens

<400>  77
aaatattctt gcttgagtaa accacagtaa gaataaggaa gtagtgactg agtgccttgc       60

cagtacagca gatgctagaa cataatgtag cattactttc cccagggttt attgttatgt      120

aagttcttgt tcagcttcct ttgttttctt tcacttctga gaatttaact ttcgtttctc      180

actcagctcc tgtggggaaa ctcatttgtg gagaccagcc ctctggcttg gtgagtgaat      240

ctggtttaca ccggctcctg ccctgccttc actcttctcc cctgattcaa gactcctctg      300

ctttggactg aagcactgca ggagtttgtg accaagaact tcaagagtca agacagaagg      360

aagccaaggg agcagtgcaa tggatttctc agtaaaggta gacatagaga aggaggtgac      420

ctgccccatc tgcctggagc tcctgacaga acctctgagc ctagattgtg gccacagctt      480

ctgccaagcc tgcatcactg caaagatcaa ggagtcagtg atcatctcaa gaggggaaag      540

cagctgtcct gtgtgtcaga ccagattcca gcctgggaac ctccgaccta atcggcatct      600

ggccaacata gttgagagag tcaaagaggt caagatgagc ccacaggagg ggcagaagag      660

agatgtctgt gagcaccatg gaaaaaaact ccagatcttc tgtaaggagg atggaaaagt      720

catttgctgg gtttgtgaac tgtctcagga acaccaaggt caccaaacat tccgcataaa      780

cgaggtggtc aaggaatgtc aggaaaagct gcaggtagcc ctgcagaggc tgataaagga      840

ggatcaagag gctgagaagc tggaagatga catcagacaa gagagaaccg cctggaagaa      900

ttatatccag atcgagagac agaagattct gaaagggttc aatgaaatga gagtcatctt      960

ggacaatgag gagcagagag agctgcaaaa gctggaggaa ggtgaggtga atgtgctgga     1020

taacctggca gcagctacag accagctggt ccagcagagg caggatgcca gcacgctcat     1080

ctcagatctc cagcggaggt tgaggggatc gtcagtagag atgctgcagg atgtgattga     1140

cgtcatgaaa aggagtgaaa gctggacatt gaagaagcca aaatctgttt ccaagaaact     1200

aaagagtgta ttccgagtac cagatctgag tgggatgctg caagttctta aagagctgac     1260

agatgtccag tactactggg tggacgtgat gctgaatcca ggcagtgcca cttcgaatgt     1320

tgctatttct gtggatcaga gacaagtgaa aactgtacgc acctgcacat ttaagaattc     1380

aaatccatgt gatttttctg cttttggtgt cttcggctgc caatatttct cttcggggaa     1440

atattactgg gaagtagatg tgtctggaaa gattgcctgg atcctgggcg tacacagtaa     1500

aataagtagt ctgaataaaa ggaagagctc tgggtttgct tttgatccaa gtgtaaatta     1560

ttcaaaagtt tactccagat atagacctca atatggctac tgggttatag gattacagaa     1620

tacatgtgaa tataatgctt ttgaggactc ctcctcttct gatcccaagg ttttgactct     1680

ctttatggct gtgcctccct gtcgtattgg ggttttccta gactatgagg caggcattgt     1740

ctcatttttc aatgtcacaa accacggagc actcatctac aagttctctg gatgtcgctt     1800

ttctcgacct gcttatccgt atttcaatcc ttggaactgc ctagtcccca tgactgtgtg     1860

cccaccgagc tcctgagtgt tctcattcct ttacccactt ctgcatagta gcccttgtgc     1920

tgagactcag attctgcacc tgagttcatc tctactgaga ccatctcttc ctttctttcc     1980

ccttctttta cttagaatgt ctttgtattc atttgctagg gcttccatag caaagcatca     2040

tagattgctg atttaaactg taattgtatt gccgtactgt gggctggaaa tcccaaatct     2100

agattccagc agagttggtt ctttctgagg tctgcaagga agggctctgt tccatgcctc     2160

tctccttggc ttgtagaagg catcttgtcc ctatgactct tcacattgtc tttatgtaca     2220

tctctgtgcc caagttttcc ctttttatta agacaccagt catactggct cagggcccac     2280

cgctaatgcc ttaatgaaat cattttaaca ttatattctc tacaaagacc ttatttccaa     2340

ataagataat atttggaggt attgggaata aaaactccaa catataaatt tgaggaaggc     2400

acgatttcac tcataacaat cttacccttt cttgcaagag atgcttgtac attattttcc     2460

taataccttg gtttcactag tagtaaacat tattattttt tttatatttg caaaggaaac     2520

atatctaatc cttcctatag aaagaacagt attgctgtaa ttccttttct tttcttcctc     2580

atttcctctg ccccttaaaa gattgaagaa agagaaactt gtcaactcat atccacgtta     2640

tctagcaaag tacataagaa tctatcacta agtaatgtat ccttcagaat gtgttggttt     2700

accagtgaca ccccatattc atcacaaaat taaagcaaga agtccatagt aatttatttg     2760

ctaatagtgg atttttaatg ctcagagttt ctgaggtcaa attttatctt ttcacttaca     2820

agctctatga tcttaaataa tttacttaat gtattttggt gtattttcct caaattaata     2880

ttggtgttca agactatatc taattcctct gatcactttg agaaacaaac ttttattaaa     2940

tgtaaggcac ttttctatga attttaaata taaaaataaa tattgttctg attattactg     3000

aaaagatgtc agccatttca atgtcttggg aaacaatttt ttgtttttgt tctgttttct     3060

ttttgcttca ataaaacaat agctggctct aaaaaaaaaa aaaaaaaaaa a              3111


<210>  78
<211>  498
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Asp Phe Ser Val Lys Val Asp Ile Glu Lys Glu Val Thr Cys Pro 
1               5                   10                  15      


Ile Cys Leu Glu Leu Leu Thr Glu Pro Leu Ser Leu Asp Cys Gly His 
            20                  25                  30          


Ser Phe Cys Gln Ala Cys Ile Thr Ala Lys Ile Lys Glu Ser Val Ile 
        35                  40                  45              


Ile Ser Arg Gly Glu Ser Ser Cys Pro Val Cys Gln Thr Arg Phe Gln 
    50                  55                  60                  


Pro Gly Asn Leu Arg Pro Asn Arg His Leu Ala Asn Ile Val Glu Arg 
65                  70                  75                  80  


Val Lys Glu Val Lys Met Ser Pro Gln Glu Gly Gln Lys Arg Asp Val 
                85                  90                  95      


Cys Glu His His Gly Lys Lys Leu Gln Ile Phe Cys Lys Glu Asp Gly 
            100                 105                 110         


Lys Val Ile Cys Trp Val Cys Glu Leu Ser Gln Glu His Gln Gly His 
        115                 120                 125             


Gln Thr Phe Arg Ile Asn Glu Val Val Lys Glu Cys Gln Glu Lys Leu 
    130                 135                 140                 


Gln Val Ala Leu Gln Arg Leu Ile Lys Glu Asp Gln Glu Ala Glu Lys 
145                 150                 155                 160 


Leu Glu Asp Asp Ile Arg Gln Glu Arg Thr Ala Trp Lys Asn Tyr Ile 
                165                 170                 175     


Gln Ile Glu Arg Gln Lys Ile Leu Lys Gly Phe Asn Glu Met Arg Val 
            180                 185                 190         


Ile Leu Asp Asn Glu Glu Gln Arg Glu Leu Gln Lys Leu Glu Glu Gly 
        195                 200                 205             


Glu Val Asn Val Leu Asp Asn Leu Ala Ala Ala Thr Asp Gln Leu Val 
    210                 215                 220                 


Gln Gln Arg Gln Asp Ala Ser Thr Leu Ile Ser Asp Leu Gln Arg Arg 
225                 230                 235                 240 


Leu Arg Gly Ser Ser Val Glu Met Leu Gln Asp Val Ile Asp Val Met 
                245                 250                 255     


Lys Arg Ser Glu Ser Trp Thr Leu Lys Lys Pro Lys Ser Val Ser Lys 
            260                 265                 270         


Lys Leu Lys Ser Val Phe Arg Val Pro Asp Leu Ser Gly Met Leu Gln 
        275                 280                 285             


Val Leu Lys Glu Leu Thr Asp Val Gln Tyr Tyr Trp Val Asp Val Met 
    290                 295                 300                 


Leu Asn Pro Gly Ser Ala Thr Ser Asn Val Ala Ile Ser Val Asp Gln 
305                 310                 315                 320 


Arg Gln Val Lys Thr Val Arg Thr Cys Thr Phe Lys Asn Ser Asn Pro 
                325                 330                 335     


Cys Asp Phe Ser Ala Phe Gly Val Phe Gly Cys Gln Tyr Phe Ser Ser 
            340                 345                 350         


Gly Lys Tyr Tyr Trp Glu Val Asp Val Ser Gly Lys Ile Ala Trp Ile 
        355                 360                 365             


Leu Gly Val His Ser Lys Ile Ser Ser Leu Asn Lys Arg Lys Ser Ser 
    370                 375                 380                 


Gly Phe Ala Phe Asp Pro Ser Val Asn Tyr Ser Lys Val Tyr Ser Arg 
385                 390                 395                 400 


Tyr Arg Pro Gln Tyr Gly Tyr Trp Val Ile Gly Leu Gln Asn Thr Cys 
                405                 410                 415     


Glu Tyr Asn Ala Phe Glu Asp Ser Ser Ser Ser Asp Pro Lys Val Leu 
            420                 425                 430         


Thr Leu Phe Met Ala Val Pro Pro Cys Arg Ile Gly Val Phe Leu Asp 
        435                 440                 445             


Tyr Glu Ala Gly Ile Val Ser Phe Phe Asn Val Thr Asn His Gly Ala 
    450                 455                 460                 


Leu Ile Tyr Lys Phe Ser Gly Cys Arg Phe Ser Arg Pro Ala Tyr Pro 
465                 470                 475                 480 


Tyr Phe Asn Pro Trp Asn Cys Leu Val Pro Met Thr Val Cys Pro Pro 
                485                 490                 495     


Ser Ser 
        


<210>  79
<211>  4396
<212>  DNA
<213>  Homo sapiens

<400>  79
gcaaggacac acccacagct tacaccattg gctgctgttt agctccctta tataacactg       60

tcttggggtt taaacgtaac tgaaaatcca caagacagaa tagccagatc tcagaggagc      120

ctggctaagc aaaaccctgc agaacggctg cctaatttac agcaaccatg agtacaaatg      180

gtgatgatca tcaggtcaag gatagtctgg agcaattgag atgtcacttt acatgggagt      240

tatccattga tgacgatgaa atgcctgatt tagaaaacag agtcttggat cagattgaat      300

tcctagacac caaatacagt gtgggaatac acaacctact agcctatgtg aaacacctga      360

aaggccagaa tgaggaagcc ctgaagagct taaaagaagc tgaaaactta atgcaggaag      420

aacatgacaa ccaagcaaat gtgaggagtc tggtgacctg gggcaacttt gcctggatgt      480

attaccacat gggcagactg gcagaagccc agacttacct ggacaaggtg gagaacattt      540

gcaagaagct ttcaaatccc ttccgctata gaatggagtg tccagaaata gactgtgagg      600

aaggatgggc cttgctgaag tgtggaggaa aaaattatga acgggccaag gcctgctttg      660

aaaaggtgct tgaagtggac cctgaaaacc ctgaatccag cgctgggtat gcgatctctg      720

cctatcgcct ggatggcttt aaattagcca caaaaaatca caagccattt tctttgcttc      780

ccctaaggca ggctgtccgc ttaaatccag acaatggata tattaaggtt ctccttgccc      840

tgaagcttca ggatgaagga caggaagctg aaggagaaaa gtacattgaa gaagctctag      900

ccaacatgtc ctcacagacc tatgtctttc gatatgcagc caagttttac cgaagaaaag      960

gctctgtgga taaagctctt gagttattaa aaaaggcctt gcaggaaaca cccacttctg     1020

tcttactgca tcaccagata gggctttgct acaaggcaca aatgatccaa atcaaggagg     1080

ctacaaaagg gcagcctaga gggcagaaca gagaaaagct agacaaaatg ataagatcag     1140

ccatatttca ttttgaatct gcagtggaaa aaaagcccac atttgaggtg gctcatctag     1200

acctggcaag aatgtatata gaagcaggca atcacagaaa agctgaagag aattttcaaa     1260

aattgttatg catgaaacca gtggtagaag aaacaatgca agacatacat ttccactatg     1320

gtcggtttca ggaatttcaa aagaaatctg acgtcaatgc aattatccat tatttaaaag     1380

ctataaaaat agaacaggca tcattaacaa gggataaaag tatcaattct ttgaagaaat     1440

tggttttaag gaaacttcgg agaaaggcat tagatctgga aagcttgagc ctccttgggt     1500

tcgtctacaa attggaagga aatatgaatg aagccctgga gtactatgag cgggccctga     1560

gactggctgc tgactttgag aactctgtga gacaaggtcc ttaggcaccc agatatcagc     1620

cactttcaca tttcatttca ttttatgcta acatttacta atcatctttt ctgcttactg     1680

ttttcagaaa cattataatt cactgtaatg atgtaattct tgaataataa atctgacaaa     1740

atattagttg tgttcaacaa ttagtgaaac agaatgtgtg tatgcatgta agaaagagaa     1800

atcatttgta tgagtgctat gtagtagaga aaaaatgtta gttaactttg taggaaataa     1860

aacattggac ttacactaaa tgtttaattc attcatttta ttgtgaaata aaaataaaat     1920

ccttagctcc tccaccaact gaacagaccc tcttggccaa ggagacccca gaaaccttaa     1980

aaactaagtt tcccaaccat gacaagatga gagatcattc acacctcatt atattccctc     2040

ccttgctaac tgccattgga ctttttccac tgagttaaac agaaacccat ggaaaacaaa     2100

gaacagaaga ctcactcctt ggctgacttc acctagctca ctccacgtag cgccacagcc     2160

agactcccct cccctcttgc ggtttccaca tgacaactga tcagccttcc ctcctgataa     2220

gtgaccactg cccacagact ggttctggcc agtccatgga ggctgcacac agggtgcctc     2280

tatgtccttt gtttcacctt ttgatataga aaggctaatt ttgctgtatt ttaatgttaa     2340

gtctccacca cagagtgaac acagaatgca tgtgacatac atgtttacat accactattg     2400

tgtgactgcc cctcatgaat attcatagcc ccccataacc tgttaactat gtgtgtctag     2460

ccaatccacc aaccataaaa cttctgtaat accctccctt cctccaagag cctgcttttg     2520

gttgctgtgg taggctctgc ttcccaggct gcaggttgca ggagaggagg ctgcagtggc     2580

tcacgcctgt aatctcagca cttcgatggg acgaggcagg cagatcacct gaacccagga     2640

gttcgagagc agccttggca atggcaaaac caaccgtctc tacaaaaaat gcaaaaactt     2700

agctgggtgt ggtggcatgc acctgtagct tcagttccag ctactcagga ggctgaggtg     2760

agtggactgc tggagccagg gagttcgagg ctgcagtgtc gagatcttgc cactgcactc     2820

cattctggat gatagaacga gaccccatct caaaaaaaaa aaaagttctc tccaattgta     2880

tatagcttgt gattttatgt caacactatc aataaatagc tttcagtgca agaaaccaaa     2940

aatactgtaa taaacaggca catattcttc ccaaacctca tgcagtttac aatctagtga     3000

gagacacaga tagcagtaca gagtcaatta aaggttagtt ttcttcatga agatgtttta     3060

attttaattc aatgtgaaag ggttccaagg agtttatctt gttttatgcc attttatttg     3120

aagcactact tactaagtca tttgctgata ttaatctagt taaatcaaga aatattacat     3180

gaaaatgttg ctaaatcaga gatcatgggt aacaatcacc tttgattatg aataatcata     3240

ttttattgaa aggcaaggca caacaaataa taagaaggaa aaaataaata agcaatgtta     3300

ttgatctttc attctgtata tgttttgggg ggaatatact agtttctttt agtggctgta     3360

acaaattacc acaaacttgg tgacttaaaa tttcacagat ttactctttc ttacagttct     3420

ggaggtcaga agtctgaaat gggtttcaat gagccaaagt caaggtattg atgacgctac     3480

actcctccgg aggctctagg cagatagcct tttccagctt ccagaggctg cctgaattct     3540

ttcatccatc ttaaaaacca acagtgtagt agcctcaaat ctctctctct gcttccttct     3600

tcacatctcc ttctctcctc tgactctttt gcctctttct tctaaggacg caccaggtcc     3660

acctgcataa tccagaataa ttgccccatc cgcaaatcct taatttaata acatctgcaa     3720

agtccctttt gctatgtaaa gtagcatgtt cacaggttct ggagacttgg ccatggatac     3780

gattgcgggg ggggcattat tcttaccaca gagcacccca agaaaatctc caaattttgg     3840

gcttccaatc cattttgctt caattattta atatttttac tccttccagt agatactgat     3900

ttcatccatt gcccttaaga aggtaggaca gagattatgg cacatctcac attaaatgct     3960

atattttcgt tggaaataca ttttttgctt caacttttat tttaaattca agggtacatg     4020

tgcaggatgt tcaggtttgt tacacaggta aacgtgtgcc atggcggttt gctgaacaga     4080

tcatcccatc accaacagat catcccattg agaggtgaag ccggctgggc ttctgggttg     4140

ggtggggact tggagaactt ttctgtctag ctaaagtatt gtaaaatgga ccagtcaaca     4200

ctctgtaaaa tggaccaatc agctctctgt aaaatggacc aatcagcagg atgtgggtgg     4260

ggccaagtaa gggaataaaa gcaggccacc cgagctggca gcggcaaccc gctcgggtcc     4320

ccttccatgc tgtggaagtt ttgttctttc gctctttcaa taaatcttgc tgctgctcaa     4380

aaaaaaaaaa aaaaaa                                                     4396


<210>  80
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Ser Thr Asn Gly Asp Asp His Gln Val Lys Asp Ser Leu Glu Gln 
1               5                   10                  15      


Leu Arg Cys His Phe Thr Trp Glu Leu Ser Ile Asp Asp Asp Glu Met 
            20                  25                  30          


Pro Asp Leu Glu Asn Arg Val Leu Asp Gln Ile Glu Phe Leu Asp Thr 
        35                  40                  45              


Lys Tyr Ser Val Gly Ile His Asn Leu Leu Ala Tyr Val Lys His Leu 
    50                  55                  60                  


Lys Gly Gln Asn Glu Glu Ala Leu Lys Ser Leu Lys Glu Ala Glu Asn 
65                  70                  75                  80  


Leu Met Gln Glu Glu His Asp Asn Gln Ala Asn Val Arg Ser Leu Val 
                85                  90                  95      


Thr Trp Gly Asn Phe Ala Trp Met Tyr Tyr His Met Gly Arg Leu Ala 
            100                 105                 110         


Glu Ala Gln Thr Tyr Leu Asp Lys Val Glu Asn Ile Cys Lys Lys Leu 
        115                 120                 125             


Ser Asn Pro Phe Arg Tyr Arg Met Glu Cys Pro Glu Ile Asp Cys Glu 
    130                 135                 140                 


Glu Gly Trp Ala Leu Leu Lys Cys Gly Gly Lys Asn Tyr Glu Arg Ala 
145                 150                 155                 160 


Lys Ala Cys Phe Glu Lys Val Leu Glu Val Asp Pro Glu Asn Pro Glu 
                165                 170                 175     


Ser Ser Ala Gly Tyr Ala Ile Ser Ala Tyr Arg Leu Asp Gly Phe Lys 
            180                 185                 190         


Leu Ala Thr Lys Asn His Lys Pro Phe Ser Leu Leu Pro Leu Arg Gln 
        195                 200                 205             


Ala Val Arg Leu Asn Pro Asp Asn Gly Tyr Ile Lys Val Leu Leu Ala 
    210                 215                 220                 


Leu Lys Leu Gln Asp Glu Gly Gln Glu Ala Glu Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Glu Glu Ala Leu Ala Asn Met Ser Ser Gln Thr Tyr Val Phe Arg Tyr 
                245                 250                 255     


Ala Ala Lys Phe Tyr Arg Arg Lys Gly Ser Val Asp Lys Ala Leu Glu 
            260                 265                 270         


Leu Leu Lys Lys Ala Leu Gln Glu Thr Pro Thr Ser Val Leu Leu His 
        275                 280                 285             


His Gln Ile Gly Leu Cys Tyr Lys Ala Gln Met Ile Gln Ile Lys Glu 
    290                 295                 300                 


Ala Thr Lys Gly Gln Pro Arg Gly Gln Asn Arg Glu Lys Leu Asp Lys 
305                 310                 315                 320 


Met Ile Arg Ser Ala Ile Phe His Phe Glu Ser Ala Val Glu Lys Lys 
                325                 330                 335     


Pro Thr Phe Glu Val Ala His Leu Asp Leu Ala Arg Met Tyr Ile Glu 
            340                 345                 350         


Ala Gly Asn His Arg Lys Ala Glu Glu Asn Phe Gln Lys Leu Leu Cys 
        355                 360                 365             


Met Lys Pro Val Val Glu Glu Thr Met Gln Asp Ile His Phe His Tyr 
    370                 375                 380                 


Gly Arg Phe Gln Glu Phe Gln Lys Lys Ser Asp Val Asn Ala Ile Ile 
385                 390                 395                 400 


His Tyr Leu Lys Ala Ile Lys Ile Glu Gln Ala Ser Leu Thr Arg Asp 
                405                 410                 415     


Lys Ser Ile Asn Ser Leu Lys Lys Leu Val Leu Arg Lys Leu Arg Arg 
            420                 425                 430         


Lys Ala Leu Asp Leu Glu Ser Leu Ser Leu Leu Gly Phe Val Tyr Lys 
        435                 440                 445             


Leu Glu Gly Asn Met Asn Glu Ala Leu Glu Tyr Tyr Glu Arg Ala Leu 
    450                 455                 460                 


Arg Leu Ala Ala Asp Phe Glu Asn Ser Val Arg Gln Gly Pro 
465                 470                 475             


<210>  81
<211>  3499
<212>  DNA
<213>  Homo sapiens

<400>  81
cgcggacccg gccggcccag gcccgcgccc gccgcggccc tgagaggccc cggcaggtcc       60

cggcccggcg gcggcagcca tggccggggg gccgggcccg ggggagcccg cagcccccgg      120

cgcccagcac ttcttgtacg aggtgccgcc ctgggtcatg tgccgcttct acaaagtgat      180

ggacgccctg gagcccgccg actggtgcca gttcgccgcc ctgatcgtgc gcgaccagac      240

cgagctgcgg ctgtgcgagc gctccgggca gcgcacggcc agcgtcctgt ggccctggat      300

caaccgcaac gcccgtgtgg ccgacctcgt gcacatcctc acgcacctgc agctgctccg      360

tgcgcgggac atcatcacag cctggcaccc tcccgccccg cttccgtccc caggcaccac      420

tgccccgagg cccagcagca tccctgcacc cgccgaggcc gaggcctgga gcccccggaa      480

gttgccatcc tcagcctcca ccttcctctc cccagctttt ccaggctccc agacccattc      540

agggcctgag ctcggcctgg tcccaagccc tgcttccctg tggcctccac cgccatctcc      600

agccccttct tctaccaagc caggcccaga gagctcagtg tccctcctgc agggagcccg      660

cccctttccg ttttgctggc ccctctgtga gatttcccgg ggcacccaca acttctcgga      720

ggagctcaag atcggggagg gtggctttgg gtgcgtgtac cgggcggtga tgaggaacac      780

ggtgtatgct gtgaagaggc tgaaggagaa cgctgacctg gagtggactg cagtgaagca      840

gagcttcctg accgaggtgg agcagctgtc caggtttcgt cacccaaaca ttgtggactt      900

tgctggctac tgtgctcaga acggcttcta ctgcctggtg tacggcttcc tgcccaacgg      960

ctccctggag gaccgtctcc actgccagac ccaggcctgc ccacctctct cctggcctca     1020

gcgactggac atccttctgg gtacagcccg ggcaattcag tttctacatc aggacagccc     1080

cagcctcatc catggagaca tcaagagttc caacgtcctt ctggatgaga ggctgacacc     1140

caagctggga gactttggcc tggcccggtt cagccgcttt gccgggtcca gccccagcca     1200

gagcagcatg gtggcccgga cacagacagt gcggggcacc ctggcctacc tgcccgagga     1260

gtacatcaag acgggaaggc tggctgtgga cacggacacc ttcagctttg gggtggtagt     1320

gctagagacc ttggctggtc agagggctgt gaagacgcac ggtgccagga ccaagtatct     1380

gaaagacctg gtggaagagg aggctgagga ggctggagtg gctttgagaa gcacccagag     1440

cacactgcaa gcaggtctgg ctgcagatgc ctgggctgct cccatcgcca tgcagatcta     1500

caagaagcac ctggacccca ggcccgggcc ctgcccacct gagctgggcc tgggcctggg     1560

ccagctggcc tgctgctgcc tgcaccgccg ggccaaaagg aggcctccta tgacccagga     1620

gaactcctac gtgtccagca ctggcagagc ccacagtggg gctgctccat ggcagcccct     1680

ggcagcgcca tcaggagcca gtgcccaggc agcagagcag ctgcagagag gccccaacca     1740

gcccgtggag agtgacgaga gcctaggcgg cctctctgct gccctgcgct cctggcactt     1800

gactccaagc tgccctctgg acccagcacc cctcagggag gccggctgtc ctcaggggga     1860

cacggcagga gaatcgagct gggggagtgg cccaggatcc cggcccacag ccgtggaagg     1920

actggccctt ggcagctctg catcatcgtc gtcagagcca ccgcagatta tcatcaaccc     1980

tgcccgacag aagatggtcc agaagctggc cctgtacgag gatggggccc tggacagcct     2040

gcagctgctg tcgtccagct ccctcccagg cttgggcctg gaacaggaca ggcaggggcc     2100

cgaagaaagt gatgaatttc agagctgatg tgttcacctg ggcagatccc ccaaatccgg     2160

aagtcaaagt tctcatggtc agaagttctc atggtgcacg agtcctcagc actctgccgg     2220

cagtgggggt gggggcccat gcccgcgggg gagagaagga ggtggccctg ctgttctagg     2280

ctctgtgggc ataggcaggc agagtggaac cctgcctcca tgccagcatc tgggggcaag     2340

gaaggctggc atcatccagt gaggaggctg gcgcatgttg ggaggctgct ggctgcacag     2400

acccgtgagg ggaggagagg ggctgctgtg caggggtgtg gagtagggag ctggctcccc     2460

tgagagccat gcagggcgtc tgcagcccag gcctctggca gcagctcttt gcccatctct     2520

ttggacagtg gccaccctgc acaatggggc cgacgaggcc tagggccctc ctacctgctt     2580

acaatttgga aaagtgtggc cgggtgcggt ggctcacgcc tgtaatccca gcactttggg     2640

aggccaaggc aggaggatcg ctggagccca gtaggtcaag accagccagg gcaacatgat     2700

gagaccctgt ctctgccaaa aaatttttta aactattagc ctggcgtggt agcgcacgcc     2760

tgtggtccca gctgctgggg aggctgaagt aggaggatca tttatgcttg ggaggtcgag     2820

gctgcagtga gtcatgattg tatgactgca ctccagcctg ggtgacagag caagaccctg     2880

tttcaaaaag aaaaaccctg ggaaaagtga agtatggctg taagtctcat ggttcagtcc     2940

tagcaagaag cgagaattct gagatcctcc agaaagtcga gcagcaccca cctccaacct     3000

cgggccagtg tcttcaggct ttactgggga cctgcgagct ggcctaatgt ggtggcctgc     3060

aagccaggcc atccctgggc gccacagacg agctccgagc caggtcaggc ttcggaggcc     3120

acaagctcag cctcaggccc aggcactgat tgtggcagag gggccactac ccaaggtcta     3180

gctaggccca agacctagtt acccagacag tgagaagccc ctggaaggca gaaaagttgg     3240

gagcatggca gacagggaag ggaaacattt tcagggaaaa gacatgtatc acatgtcttc     3300

agaagcaagt caggtttcat gtaaccgagt gtcctcttgc gtgtccaaaa gtagcccagg     3360

gctgtagcac aggcttcaca gtgattttgt gttcagccgt gagtcacact acatgccccc     3420

gtgaagctgg gcattggtga cgtccaggtt gtccttgagt aataaaaacg tatgttgcaa     3480

taaaaaaaaa aaaaaaaaa                                                  3499


<210>  82
<211>  682
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Ala Gly Gly Pro Gly Pro Gly Glu Pro Ala Ala Pro Gly Ala Gln 
1               5                   10                  15      


His Phe Leu Tyr Glu Val Pro Pro Trp Val Met Cys Arg Phe Tyr Lys 
            20                  25                  30          


Val Met Asp Ala Leu Glu Pro Ala Asp Trp Cys Gln Phe Ala Ala Leu 
        35                  40                  45              


Ile Val Arg Asp Gln Thr Glu Leu Arg Leu Cys Glu Arg Ser Gly Gln 
    50                  55                  60                  


Arg Thr Ala Ser Val Leu Trp Pro Trp Ile Asn Arg Asn Ala Arg Val 
65                  70                  75                  80  


Ala Asp Leu Val His Ile Leu Thr His Leu Gln Leu Leu Arg Ala Arg 
                85                  90                  95      


Asp Ile Ile Thr Ala Trp His Pro Pro Ala Pro Leu Pro Ser Pro Gly 
            100                 105                 110         


Thr Thr Ala Pro Arg Pro Ser Ser Ile Pro Ala Pro Ala Glu Ala Glu 
        115                 120                 125             


Ala Trp Ser Pro Arg Lys Leu Pro Ser Ser Ala Ser Thr Phe Leu Ser 
    130                 135                 140                 


Pro Ala Phe Pro Gly Ser Gln Thr His Ser Gly Pro Glu Leu Gly Leu 
145                 150                 155                 160 


Val Pro Ser Pro Ala Ser Leu Trp Pro Pro Pro Pro Ser Pro Ala Pro 
                165                 170                 175     


Ser Ser Thr Lys Pro Gly Pro Glu Ser Ser Val Ser Leu Leu Gln Gly 
            180                 185                 190         


Ala Arg Pro Phe Pro Phe Cys Trp Pro Leu Cys Glu Ile Ser Arg Gly 
        195                 200                 205             


Thr His Asn Phe Ser Glu Glu Leu Lys Ile Gly Glu Gly Gly Phe Gly 
    210                 215                 220                 


Cys Val Tyr Arg Ala Val Met Arg Asn Thr Val Tyr Ala Val Lys Arg 
225                 230                 235                 240 


Leu Lys Glu Asn Ala Asp Leu Glu Trp Thr Ala Val Lys Gln Ser Phe 
                245                 250                 255     


Leu Thr Glu Val Glu Gln Leu Ser Arg Phe Arg His Pro Asn Ile Val 
            260                 265                 270         


Asp Phe Ala Gly Tyr Cys Ala Gln Asn Gly Phe Tyr Cys Leu Val Tyr 
        275                 280                 285             


Gly Phe Leu Pro Asn Gly Ser Leu Glu Asp Arg Leu His Cys Gln Thr 
    290                 295                 300                 


Gln Ala Cys Pro Pro Leu Ser Trp Pro Gln Arg Leu Asp Ile Leu Leu 
305                 310                 315                 320 


Gly Thr Ala Arg Ala Ile Gln Phe Leu His Gln Asp Ser Pro Ser Leu 
                325                 330                 335     


Ile His Gly Asp Ile Lys Ser Ser Asn Val Leu Leu Asp Glu Arg Leu 
            340                 345                 350         


Thr Pro Lys Leu Gly Asp Phe Gly Leu Ala Arg Phe Ser Arg Phe Ala 
        355                 360                 365             


Gly Ser Ser Pro Ser Gln Ser Ser Met Val Ala Arg Thr Gln Thr Val 
    370                 375                 380                 


Arg Gly Thr Leu Ala Tyr Leu Pro Glu Glu Tyr Ile Lys Thr Gly Arg 
385                 390                 395                 400 


Leu Ala Val Asp Thr Asp Thr Phe Ser Phe Gly Val Val Val Leu Glu 
                405                 410                 415     


Thr Leu Ala Gly Gln Arg Ala Val Lys Thr His Gly Ala Arg Thr Lys 
            420                 425                 430         


Tyr Leu Lys Asp Leu Val Glu Glu Glu Ala Glu Glu Ala Gly Val Ala 
        435                 440                 445             


Leu Arg Ser Thr Gln Ser Thr Leu Gln Ala Gly Leu Ala Ala Asp Ala 
    450                 455                 460                 


Trp Ala Ala Pro Ile Ala Met Gln Ile Tyr Lys Lys His Leu Asp Pro 
465                 470                 475                 480 


Arg Pro Gly Pro Cys Pro Pro Glu Leu Gly Leu Gly Leu Gly Gln Leu 
                485                 490                 495     


Ala Cys Cys Cys Leu His Arg Arg Ala Lys Arg Arg Pro Pro Met Thr 
            500                 505                 510         


Gln Glu Asn Ser Tyr Val Ser Ser Thr Gly Arg Ala His Ser Gly Ala 
        515                 520                 525             


Ala Pro Trp Gln Pro Leu Ala Ala Pro Ser Gly Ala Ser Ala Gln Ala 
    530                 535                 540                 


Ala Glu Gln Leu Gln Arg Gly Pro Asn Gln Pro Val Glu Ser Asp Glu 
545                 550                 555                 560 


Ser Leu Gly Gly Leu Ser Ala Ala Leu Arg Ser Trp His Leu Thr Pro 
                565                 570                 575     


Ser Cys Pro Leu Asp Pro Ala Pro Leu Arg Glu Ala Gly Cys Pro Gln 
            580                 585                 590         


Gly Asp Thr Ala Gly Glu Ser Ser Trp Gly Ser Gly Pro Gly Ser Arg 
        595                 600                 605             


Pro Thr Ala Val Glu Gly Leu Ala Leu Gly Ser Ser Ala Ser Ser Ser 
    610                 615                 620                 


Ser Glu Pro Pro Gln Ile Ile Ile Asn Pro Ala Arg Gln Lys Met Val 
625                 630                 635                 640 


Gln Lys Leu Ala Leu Tyr Glu Asp Gly Ala Leu Asp Ser Leu Gln Leu 
                645                 650                 655     


Leu Ser Ser Ser Ser Leu Pro Gly Leu Gly Leu Glu Gln Asp Arg Gln 
            660                 665                 670         


Gly Pro Glu Glu Ser Asp Glu Phe Gln Ser 
        675                 680         


<210>  83
<211>  3352
<212>  DNA
<213>  Homo sapiens

<400>  83
cgcggacccg gccggcccag gcccgcgccc gccgcggccc tgagaggccc cggcaggtcc       60

cggcccggcg gcggcagcca tggccggggg gccgggcccg ggggagcccg cagcccccgg      120

cgcccagcac ttcttgtacg aggtgccgcc ctgggtcatg tgccgcttct acaaagtgat      180

ggacgccctg gagcccgccg actggtgcca gttcgccgcc ctgatcgtgc gcgaccagac      240

cgagctgcgg ctgtgcgagc gctccgggca gcgcacggcc agcgtcctgt ggccctggat      300

caaccgcaac gcccgtgtgg ccgacctcgt gcacatcctc acgcacctgc agctgctccg      360

tgcgcgggac atcatcacag cctggcaccc tcccgccccg cttccgtccc caggcaccac      420

tgccccgagg cccagcagca tccctgcacc cgccgaggcc gaggcctgga gcccccggaa      480

gttgccatcc tcagcctcca ccttcctctc cccagctttt ccaggctccc agacccattc      540

agggcctgag ctcggcctgg tcccaagccc tgcttccctg tggcctccac cgccatctcc      600

agccccttct tctaccaagc caggcccaga gagctcagtg tccctcctgc agggagcccg      660

cccctttccg ttttgctggc ccctctgtga gatttcccgg ggcacccaca acttctcgga      720

ggagctcaag atcggggagg gtggctttgg gtgcgtgtac cgggcggtga tgaggaacac      780

ggtgtatgct gtgaagaggc tgaaggagaa cgctgacctg gagtggactg cagtgaagca      840

gagcttcctg accgaggtgg agcagctgtc caggtttcgt cacccaaaca ttgtggactt      900

tgctggctac tgtgctcaga acggcttcta ctgcctggtg tacggcttcc tgcccaacgg      960

ctccctggag gaccgtctcc actgccagac ccaggcctgc ccacctctct cctggcctca     1020

gcgactggac atccttctgg gtacagcccg ggcaattcag tttctacatc aggacagccc     1080

cagcctcatc catggagaca tcaagagttc caacgtcctt ctggatgaga ggctgacacc     1140

caagctggga gactttggcc tggcccggtt cagccgcttt gccgggtcca gccccagcca     1200

gagcagcatg gtggcccgga cacagacagt gcggggcacc ctggcctacc tgcccgagga     1260

gtacatcaag acgggaaggc tggctgtgga cacggacacc ttcagctttg gggtggtagt     1320

gctagagacc ttggctggtc agagggctgt gaagacgcac ggtgccagga ccaagtatct     1380

ggtgtacgag aggctagaga agctgcaggc agtggtggcg ggggtgcccg ggcattcgga     1440

ggccgccagc tgcatccccc cttccccgca ggagaactcc tacgtgtcca gcactggcag     1500

agcccacagt ggggctgctc catggcagcc cctggcagcg ccatcaggag ccagtgccca     1560

ggcagcagag cagctgcaga gaggccccaa ccagcccgtg gagagtgacg agagcctagg     1620

cggcctctct gctgccctgc gctcctggca cttgactcca agctgccctc tggacccagc     1680

acccctcagg gaggccggct gtcctcaggg ggacacggca ggagaatcga gctgggggag     1740

tggcccagga tcccggccca cagccgtgga aggactggcc cttggcagct ctgcatcatc     1800

gtcgtcagag ccaccgcaga ttatcatcaa ccctgcccga cagaagatgg tccagaagct     1860

ggccctgtac gaggatgggg ccctggacag cctgcagctg ctgtcgtcca gctccctccc     1920

aggcttgggc ctggaacagg acaggcaggg gcccgaagaa agtgatgaat ttcagagctg     1980

atgtgttcac ctgggcagat cccccaaatc cggaagtcaa agttctcatg gtcagaagtt     2040

ctcatggtgc acgagtcctc agcactctgc cggcagtggg ggtgggggcc catgcccgcg     2100

ggggagagaa ggaggtggcc ctgctgttct aggctctgtg ggcataggca ggcagagtgg     2160

aaccctgcct ccatgccagc atctgggggc aaggaaggct ggcatcatcc agtgaggagg     2220

ctggcgcatg ttgggaggct gctggctgca cagacccgtg aggggaggag aggggctgct     2280

gtgcaggggt gtggagtagg gagctggctc ccctgagagc catgcagggc gtctgcagcc     2340

caggcctctg gcagcagctc tttgcccatc tctttggaca gtggccaccc tgcacaatgg     2400

ggccgacgag gcctagggcc ctcctacctg cttacaattt ggaaaagtgt ggccgggtgc     2460

ggtggctcac gcctgtaatc ccagcacttt gggaggccaa ggcaggagga tcgctggagc     2520

ccagtaggtc aagaccagcc agggcaacat gatgagaccc tgtctctgcc aaaaaatttt     2580

ttaaactatt agcctggcgt ggtagcgcac gcctgtggtc ccagctgctg gggaggctga     2640

agtaggagga tcatttatgc ttgggaggtc gaggctgcag tgagtcatga ttgtatgact     2700

gcactccagc ctgggtgaca gagcaagacc ctgtttcaaa aagaaaaacc ctgggaaaag     2760

tgaagtatgg ctgtaagtct catggttcag tcctagcaag aagcgagaat tctgagatcc     2820

tccagaaagt cgagcagcac ccacctccaa cctcgggcca gtgtcttcag gctttactgg     2880

ggacctgcga gctggcctaa tgtggtggcc tgcaagccag gccatccctg ggcgccacag     2940

acgagctccg agccaggtca ggcttcggag gccacaagct cagcctcagg cccaggcact     3000

gattgtggca gaggggccac tacccaaggt ctagctaggc ccaagaccta gttacccaga     3060

cagtgagaag cccctggaag gcagaaaagt tgggagcatg gcagacaggg aagggaaaca     3120

ttttcaggga aaagacatgt atcacatgtc ttcagaagca agtcaggttt catgtaaccg     3180

agtgtcctct tgcgtgtcca aaagtagccc agggctgtag cacaggcttc acagtgattt     3240

tgtgttcagc cgtgagtcac actacatgcc cccgtgaagc tgggcattgg tgacgtccag     3300

gttgtccttg agtaataaaa acgtatgttg caataaaaaa aaaaaaaaaa aa             3352


<210>  84
<211>  633
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Ala Gly Gly Pro Gly Pro Gly Glu Pro Ala Ala Pro Gly Ala Gln 
1               5                   10                  15      


His Phe Leu Tyr Glu Val Pro Pro Trp Val Met Cys Arg Phe Tyr Lys 
            20                  25                  30          


Val Met Asp Ala Leu Glu Pro Ala Asp Trp Cys Gln Phe Ala Ala Leu 
        35                  40                  45              


Ile Val Arg Asp Gln Thr Glu Leu Arg Leu Cys Glu Arg Ser Gly Gln 
    50                  55                  60                  


Arg Thr Ala Ser Val Leu Trp Pro Trp Ile Asn Arg Asn Ala Arg Val 
65                  70                  75                  80  


Ala Asp Leu Val His Ile Leu Thr His Leu Gln Leu Leu Arg Ala Arg 
                85                  90                  95      


Asp Ile Ile Thr Ala Trp His Pro Pro Ala Pro Leu Pro Ser Pro Gly 
            100                 105                 110         


Thr Thr Ala Pro Arg Pro Ser Ser Ile Pro Ala Pro Ala Glu Ala Glu 
        115                 120                 125             


Ala Trp Ser Pro Arg Lys Leu Pro Ser Ser Ala Ser Thr Phe Leu Ser 
    130                 135                 140                 


Pro Ala Phe Pro Gly Ser Gln Thr His Ser Gly Pro Glu Leu Gly Leu 
145                 150                 155                 160 


Val Pro Ser Pro Ala Ser Leu Trp Pro Pro Pro Pro Ser Pro Ala Pro 
                165                 170                 175     


Ser Ser Thr Lys Pro Gly Pro Glu Ser Ser Val Ser Leu Leu Gln Gly 
            180                 185                 190         


Ala Arg Pro Phe Pro Phe Cys Trp Pro Leu Cys Glu Ile Ser Arg Gly 
        195                 200                 205             


Thr His Asn Phe Ser Glu Glu Leu Lys Ile Gly Glu Gly Gly Phe Gly 
    210                 215                 220                 


Cys Val Tyr Arg Ala Val Met Arg Asn Thr Val Tyr Ala Val Lys Arg 
225                 230                 235                 240 


Leu Lys Glu Asn Ala Asp Leu Glu Trp Thr Ala Val Lys Gln Ser Phe 
                245                 250                 255     


Leu Thr Glu Val Glu Gln Leu Ser Arg Phe Arg His Pro Asn Ile Val 
            260                 265                 270         


Asp Phe Ala Gly Tyr Cys Ala Gln Asn Gly Phe Tyr Cys Leu Val Tyr 
        275                 280                 285             


Gly Phe Leu Pro Asn Gly Ser Leu Glu Asp Arg Leu His Cys Gln Thr 
    290                 295                 300                 


Gln Ala Cys Pro Pro Leu Ser Trp Pro Gln Arg Leu Asp Ile Leu Leu 
305                 310                 315                 320 


Gly Thr Ala Arg Ala Ile Gln Phe Leu His Gln Asp Ser Pro Ser Leu 
                325                 330                 335     


Ile His Gly Asp Ile Lys Ser Ser Asn Val Leu Leu Asp Glu Arg Leu 
            340                 345                 350         


Thr Pro Lys Leu Gly Asp Phe Gly Leu Ala Arg Phe Ser Arg Phe Ala 
        355                 360                 365             


Gly Ser Ser Pro Ser Gln Ser Ser Met Val Ala Arg Thr Gln Thr Val 
    370                 375                 380                 


Arg Gly Thr Leu Ala Tyr Leu Pro Glu Glu Tyr Ile Lys Thr Gly Arg 
385                 390                 395                 400 


Leu Ala Val Asp Thr Asp Thr Phe Ser Phe Gly Val Val Val Leu Glu 
                405                 410                 415     


Thr Leu Ala Gly Gln Arg Ala Val Lys Thr His Gly Ala Arg Thr Lys 
            420                 425                 430         


Tyr Leu Val Tyr Glu Arg Leu Glu Lys Leu Gln Ala Val Val Ala Gly 
        435                 440                 445             


Val Pro Gly His Ser Glu Ala Ala Ser Cys Ile Pro Pro Ser Pro Gln 
    450                 455                 460                 


Glu Asn Ser Tyr Val Ser Ser Thr Gly Arg Ala His Ser Gly Ala Ala 
465                 470                 475                 480 


Pro Trp Gln Pro Leu Ala Ala Pro Ser Gly Ala Ser Ala Gln Ala Ala 
                485                 490                 495     


Glu Gln Leu Gln Arg Gly Pro Asn Gln Pro Val Glu Ser Asp Glu Ser 
            500                 505                 510         


Leu Gly Gly Leu Ser Ala Ala Leu Arg Ser Trp His Leu Thr Pro Ser 
        515                 520                 525             


Cys Pro Leu Asp Pro Ala Pro Leu Arg Glu Ala Gly Cys Pro Gln Gly 
    530                 535                 540                 


Asp Thr Ala Gly Glu Ser Ser Trp Gly Ser Gly Pro Gly Ser Arg Pro 
545                 550                 555                 560 


Thr Ala Val Glu Gly Leu Ala Leu Gly Ser Ser Ala Ser Ser Ser Ser 
                565                 570                 575     


Glu Pro Pro Gln Ile Ile Ile Asn Pro Ala Arg Gln Lys Met Val Gln 
            580                 585                 590         


Lys Leu Ala Leu Tyr Glu Asp Gly Ala Leu Asp Ser Leu Gln Leu Leu 
        595                 600                 605             


Ser Ser Ser Ser Leu Pro Gly Leu Gly Leu Glu Gln Asp Arg Gln Gly 
    610                 615                 620                 


Pro Glu Glu Ser Asp Glu Phe Gln Ser 
625                 630             


<210>  85
<211>  3589
<212>  DNA
<213>  Homo sapiens

<400>  85
cgcggacccg gccggcccag gcccgcgccc gccgcggccc tgagaggccc cggcaggtcc       60

cggcccggcg gcggcagcca tggccggggg gccgggcccg ggggagcccg cagcccccgg      120

cgcccagcac ttcttgtacg aggtgccgcc ctgggtcatg tgccgcttct acaaagtgat      180

ggacgccctg gagcccgccg actggtgcca gttcgccgcc ctgatcgtgc gcgaccagac      240

cgagctgcgg ctgtgcgagc gctccgggca gcgcacggcc agcgtcctgt ggccctggat      300

caaccgcaac gcccgtgtgg ccgacctcgt gcacatcctc acgcacctgc agctgctccg      360

tgcgcgggac atcatcacag cctggcaccc tcccgccccg cttccgtccc caggcaccac      420

tgccccgagg cccagcagca tccctgcacc cgccgaggcc gaggcctgga gcccccggaa      480

gttgccatcc tcagcctcca ccttcctctc cccagctttt ccaggctccc agacccattc      540

agggcctgag ctcggcctgg tcccaagccc tgcttccctg tggcctccac cgccatctcc      600

agccccttct tctaccaagc caggcccaga gagctcagtg tccctcctgc agggagcccg      660

cccctttccg ttttgctggc ccctctgtga gatttcccgg ggcacccaca acttctcgga      720

ggagctcaag atcggggagg gtggctttgg gtgcgtgtac cgggcggtga tgaggaacac      780

ggtgtatgct gtgaagaggc tgaaggagaa cgctgacctg gagtggactg cagtgaagca      840

gagcttcctg accgaggtgg agcagctgtc caggtttcgt cacccaaaca ttgtggactt      900

tgctggctac tgtgctcaga acggcttcta ctgcctggtg tacggcttcc tgcccaacgg      960

ctccctggag gaccgtctcc actgccagac ccaggcctgc ccacctctct cctggcctca     1020

gcgactggac atccttctgg gtacagcccg ggcaattcag tttctacatc aggacagccc     1080

cagcctcatc catggagaca tcaagagttc caacgtcctt ctggatgaga ggctgacacc     1140

caagctggga gactttggcc tggcccggtt cagccgcttt gccgggtcca gccccagcca     1200

gagcagcatg gtggcccgga cacagacagt gcggggcacc ctggcctacc tgcccgagga     1260

gtacatcaag acgggaaggc tggctgtgga cacggacacc ttcagctttg gggtggtagt     1320

gctagagacc ttggctggtc agagggctgt gaagacgcac ggtgccagga ccaagtatct     1380

gaaagacctg gtggaagagg aggctgagga ggctggagtg gctttgagaa gcacccagag     1440

cacactgcaa gcaggtctgg ctgcagatgc ctgggctgct cccatcgcca tgcagatcta     1500

caagaagcac ctggacccca ggcccgggcc ctgcccacct gagctgggcc tgggcctggg     1560

ccagctggcc tgctgctgcc tgcaccgccg ggccaaaagg aggcctccta tgacccaggt     1620

gtacgagagg ctagagaagc tgcaggcagt ggtggcgggg gtgcccgggc attcggaggc     1680

cgccagctgc atcccccctt ccccgcagga gaactcctac gtgtccagca ctggcagagc     1740

ccacagtggg gctgctccat ggcagcccct ggcagcgcca tcaggagcca gtgcccaggc     1800

agcagagcag ctgcagagag gccccaacca gcccgtggag agtgacgaga gcctaggcgg     1860

cctctctgct gccctgcgct cctggcactt gactccaagc tgccctctgg acccagcacc     1920

cctcagggag gccggctgtc ctcaggggga cacggcagga gaatcgagct gggggagtgg     1980

cccaggatcc cggcccacag ccgtggaagg actggccctt ggcagctctg catcatcgtc     2040

gtcagagcca ccgcagatta tcatcaaccc tgcccgacag aagatggtcc agaagctggc     2100

cctgtacgag gatggggccc tggacagcct gcagctgctg tcgtccagct ccctcccagg     2160

cttgggcctg gaacaggaca ggcaggggcc cgaagaaagt gatgaatttc agagctgatg     2220

tgttcacctg ggcagatccc ccaaatccgg aagtcaaagt tctcatggtc agaagttctc     2280

atggtgcacg agtcctcagc actctgccgg cagtgggggt gggggcccat gcccgcgggg     2340

gagagaagga ggtggccctg ctgttctagg ctctgtgggc ataggcaggc agagtggaac     2400

cctgcctcca tgccagcatc tgggggcaag gaaggctggc atcatccagt gaggaggctg     2460

gcgcatgttg ggaggctgct ggctgcacag acccgtgagg ggaggagagg ggctgctgtg     2520

caggggtgtg gagtagggag ctggctcccc tgagagccat gcagggcgtc tgcagcccag     2580

gcctctggca gcagctcttt gcccatctct ttggacagtg gccaccctgc acaatggggc     2640

cgacgaggcc tagggccctc ctacctgctt acaatttgga aaagtgtggc cgggtgcggt     2700

ggctcacgcc tgtaatccca gcactttggg aggccaaggc aggaggatcg ctggagccca     2760

gtaggtcaag accagccagg gcaacatgat gagaccctgt ctctgccaaa aaatttttta     2820

aactattagc ctggcgtggt agcgcacgcc tgtggtccca gctgctgggg aggctgaagt     2880

aggaggatca tttatgcttg ggaggtcgag gctgcagtga gtcatgattg tatgactgca     2940

ctccagcctg ggtgacagag caagaccctg tttcaaaaag aaaaaccctg ggaaaagtga     3000

agtatggctg taagtctcat ggttcagtcc tagcaagaag cgagaattct gagatcctcc     3060

agaaagtcga gcagcaccca cctccaacct cgggccagtg tcttcaggct ttactgggga     3120

cctgcgagct ggcctaatgt ggtggcctgc aagccaggcc atccctgggc gccacagacg     3180

agctccgagc caggtcaggc ttcggaggcc acaagctcag cctcaggccc aggcactgat     3240

tgtggcagag gggccactac ccaaggtcta gctaggccca agacctagtt acccagacag     3300

tgagaagccc ctggaaggca gaaaagttgg gagcatggca gacagggaag ggaaacattt     3360

tcagggaaaa gacatgtatc acatgtcttc agaagcaagt caggtttcat gtaaccgagt     3420

gtcctcttgc gtgtccaaaa gtagcccagg gctgtagcac aggcttcaca gtgattttgt     3480

gttcagccgt gagtcacact acatgccccc gtgaagctgg gcattggtga cgtccaggtt     3540

gtccttgagt aataaaaacg tatgttgcaa taaaaaaaaa aaaaaaaaa                 3589


<210>  86
<211>  712
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Ala Gly Gly Pro Gly Pro Gly Glu Pro Ala Ala Pro Gly Ala Gln 
1               5                   10                  15      


His Phe Leu Tyr Glu Val Pro Pro Trp Val Met Cys Arg Phe Tyr Lys 
            20                  25                  30          


Val Met Asp Ala Leu Glu Pro Ala Asp Trp Cys Gln Phe Ala Ala Leu 
        35                  40                  45              


Ile Val Arg Asp Gln Thr Glu Leu Arg Leu Cys Glu Arg Ser Gly Gln 
    50                  55                  60                  


Arg Thr Ala Ser Val Leu Trp Pro Trp Ile Asn Arg Asn Ala Arg Val 
65                  70                  75                  80  


Ala Asp Leu Val His Ile Leu Thr His Leu Gln Leu Leu Arg Ala Arg 
                85                  90                  95      


Asp Ile Ile Thr Ala Trp His Pro Pro Ala Pro Leu Pro Ser Pro Gly 
            100                 105                 110         


Thr Thr Ala Pro Arg Pro Ser Ser Ile Pro Ala Pro Ala Glu Ala Glu 
        115                 120                 125             


Ala Trp Ser Pro Arg Lys Leu Pro Ser Ser Ala Ser Thr Phe Leu Ser 
    130                 135                 140                 


Pro Ala Phe Pro Gly Ser Gln Thr His Ser Gly Pro Glu Leu Gly Leu 
145                 150                 155                 160 


Val Pro Ser Pro Ala Ser Leu Trp Pro Pro Pro Pro Ser Pro Ala Pro 
                165                 170                 175     


Ser Ser Thr Lys Pro Gly Pro Glu Ser Ser Val Ser Leu Leu Gln Gly 
            180                 185                 190         


Ala Arg Pro Phe Pro Phe Cys Trp Pro Leu Cys Glu Ile Ser Arg Gly 
        195                 200                 205             


Thr His Asn Phe Ser Glu Glu Leu Lys Ile Gly Glu Gly Gly Phe Gly 
    210                 215                 220                 


Cys Val Tyr Arg Ala Val Met Arg Asn Thr Val Tyr Ala Val Lys Arg 
225                 230                 235                 240 


Leu Lys Glu Asn Ala Asp Leu Glu Trp Thr Ala Val Lys Gln Ser Phe 
                245                 250                 255     


Leu Thr Glu Val Glu Gln Leu Ser Arg Phe Arg His Pro Asn Ile Val 
            260                 265                 270         


Asp Phe Ala Gly Tyr Cys Ala Gln Asn Gly Phe Tyr Cys Leu Val Tyr 
        275                 280                 285             


Gly Phe Leu Pro Asn Gly Ser Leu Glu Asp Arg Leu His Cys Gln Thr 
    290                 295                 300                 


Gln Ala Cys Pro Pro Leu Ser Trp Pro Gln Arg Leu Asp Ile Leu Leu 
305                 310                 315                 320 


Gly Thr Ala Arg Ala Ile Gln Phe Leu His Gln Asp Ser Pro Ser Leu 
                325                 330                 335     


Ile His Gly Asp Ile Lys Ser Ser Asn Val Leu Leu Asp Glu Arg Leu 
            340                 345                 350         


Thr Pro Lys Leu Gly Asp Phe Gly Leu Ala Arg Phe Ser Arg Phe Ala 
        355                 360                 365             


Gly Ser Ser Pro Ser Gln Ser Ser Met Val Ala Arg Thr Gln Thr Val 
    370                 375                 380                 


Arg Gly Thr Leu Ala Tyr Leu Pro Glu Glu Tyr Ile Lys Thr Gly Arg 
385                 390                 395                 400 


Leu Ala Val Asp Thr Asp Thr Phe Ser Phe Gly Val Val Val Leu Glu 
                405                 410                 415     


Thr Leu Ala Gly Gln Arg Ala Val Lys Thr His Gly Ala Arg Thr Lys 
            420                 425                 430         


Tyr Leu Lys Asp Leu Val Glu Glu Glu Ala Glu Glu Ala Gly Val Ala 
        435                 440                 445             


Leu Arg Ser Thr Gln Ser Thr Leu Gln Ala Gly Leu Ala Ala Asp Ala 
    450                 455                 460                 


Trp Ala Ala Pro Ile Ala Met Gln Ile Tyr Lys Lys His Leu Asp Pro 
465                 470                 475                 480 


Arg Pro Gly Pro Cys Pro Pro Glu Leu Gly Leu Gly Leu Gly Gln Leu 
                485                 490                 495     


Ala Cys Cys Cys Leu His Arg Arg Ala Lys Arg Arg Pro Pro Met Thr 
            500                 505                 510         


Gln Val Tyr Glu Arg Leu Glu Lys Leu Gln Ala Val Val Ala Gly Val 
        515                 520                 525             


Pro Gly His Ser Glu Ala Ala Ser Cys Ile Pro Pro Ser Pro Gln Glu 
    530                 535                 540                 


Asn Ser Tyr Val Ser Ser Thr Gly Arg Ala His Ser Gly Ala Ala Pro 
545                 550                 555                 560 


Trp Gln Pro Leu Ala Ala Pro Ser Gly Ala Ser Ala Gln Ala Ala Glu 
                565                 570                 575     


Gln Leu Gln Arg Gly Pro Asn Gln Pro Val Glu Ser Asp Glu Ser Leu 
            580                 585                 590         


Gly Gly Leu Ser Ala Ala Leu Arg Ser Trp His Leu Thr Pro Ser Cys 
        595                 600                 605             


Pro Leu Asp Pro Ala Pro Leu Arg Glu Ala Gly Cys Pro Gln Gly Asp 
    610                 615                 620                 


Thr Ala Gly Glu Ser Ser Trp Gly Ser Gly Pro Gly Ser Arg Pro Thr 
625                 630                 635                 640 


Ala Val Glu Gly Leu Ala Leu Gly Ser Ser Ala Ser Ser Ser Ser Glu 
                645                 650                 655     


Pro Pro Gln Ile Ile Ile Asn Pro Ala Arg Gln Lys Met Val Gln Lys 
            660                 665                 670         


Leu Ala Leu Tyr Glu Asp Gly Ala Leu Asp Ser Leu Gln Leu Leu Ser 
        675                 680                 685             


Ser Ser Ser Leu Pro Gly Leu Gly Leu Glu Gln Asp Arg Gln Gly Pro 
    690                 695                 700                 


Glu Glu Ser Asp Glu Phe Gln Ser 
705                 710         


<210>  87
<211>  3469
<212>  DNA
<213>  Homo sapiens

<400>  87
gcccctggct agagaagccg cagcccgcag tgtccgaccc agtcgtcccg cgccggagcc       60

ggccccgtag cgtgccatgg cctgctacat ctaccagctg ccctcctggg tgctggacga      120

cctgtgccgc aacatggacg cgctcagcga gtgggactgg atggagttcg cctcctacgt      180

gatcacagac ctgacccagc tgcggaagat caagtccatg gagcgggtgc agggtgtgag      240

catcacgcgg gagctgctgt ggtggtgggg catgcggcag gccaccgtcc agcaacttgt      300

ggacctcctg tgccgcctgg agctctaccg ggctgcccag atcatcctga actggaaacc      360

ggctcctgaa atcaggtgtc ccattccagc cttccctgac tctgtgaagc cagaaaagcc      420

tttggcagct tctgtaagaa aggctgagga tgaacaggaa gaggggcagc ctgtgaggat      480

ggccaccttt ccaggcccag ggtcctctcc agccagagcc caccagccgg cctttctcca      540

gcctcctgaa gaagatgccc ctcattcctt gagaagcgac ctccccactt cgtctgattc      600

aaaggacttc agcacctcca ttcctaagca ggaaaaactt ttgagcttgg ctggagacag      660

ccttttctgg agtgaggcag acgtggtcca ggcaaccgat gacttcaatc aaaaccgcaa      720

aatcagccag gggacctttg ctgacgtcta cagagggcac aggcacggga agccattcgt      780

cttcaagaag ctcagagaga cagcctgttc aagtccagga tcaatcgaaa gattcttcca      840

ggcagagttg cagatttgtc ttagatgctg ccaccccaat gtcttacctg tgctgggctt      900

ctgtgctgca agacagtttc acagcttcat ctacccctac atggcaaatg gttccctaca      960

ggacagactg cagggtcagg gtggctcgga ccccctcccc tggccccagc gtgtcagcat     1020

ctgctcaggg ctgctctgtg ccgtcgagta cctgcatggt ctggagatca tccacagcaa     1080

cgtcaagagc tctaatgtct tgctggacca aaatctcacc cccaaacttg ctcacccaat     1140

ggctcatctg tgtcctgtca acaaaaggtc aaaatacacc atgatgaaga ctcacctgct     1200

ccggacgtca gccgcgtatc tgccagagga tttcatccgg gtggggcagc tgacaaagcg     1260

agtggacatc ttcagctgtg gaatagtgtt ggccgaggtc ctcacgggca tccctgcaat     1320

ggataacaac cgaagcccgg tttacctgaa ggacttactc ctcagtgata ttccaagcag     1380

caccgcctcg ctctgctcca ggaagacggg cgtggagaac gtgatggcaa aggagatctg     1440

ccagaagtac ctggagaagg gcgcagggag gcttccggag gactgcgccg aggccctggc     1500

cacggctgcc tgcctgtgcc tgcggaggcg taacaccagc ctgcaggagg tgtgtggctc     1560

tgtggctgct gtggaagagc ggctccgagg tcgggagacg ttgctccctt ggagtgggct     1620

ttctgagggt acaggctctt cttccaacac cccagaggaa acagacgacg ttgacaattc     1680

cagccttgat gcctcctcct ccatgagtgt ggcaccctgg gcaggggctg ccaccccact     1740

tctccccaca gagaatgggg aaggaaggct gcgggtcatc gtgggaaggg aggctgactc     1800

ctcctctgag gcctgtgttg gcctggagcc tccccaggat gttacagaaa cttcgtggca     1860

aattgagatc aatgaggcca aaaggaaact gatggagaat attctgctct acaaagagga     1920

aaaagtggac agcattgagc tctttggccc ctgatgaccg gaacacagct gaggaccctt     1980

gtcctcagtt ggaaagatga gcatcagatc aagaaaaagg tctgaggcag aatccaagat     2040

ctgccaggaa acacacaaca aaacatctgc tgtcctgggt gggagggaaa cttcatttca     2100

ctggaatgag ttgggagaga aaggccctca gcttttagag acacaaaaat ccatgaagtc     2160

tcttcctttc tgggctttgt tagtcagagc aggggatcag aggagactga agcagaaacc     2220

ctgcacacgg gcccaggatg tggctgattt tgtggttccg gggagtatgt gatgataatc     2280

acccccagca gattccatta cctcagcagc tcttgttccc ccgccactgg cagttctgca     2340

atgccatagc attttccaga gctaagatct ctgggttgta tttgctgaca gcctgcaagc     2400

ttgcatgctc tgaaagattt tttttagttt ttaatttttt tgtagagatg gggtctcgct     2460

ttgttggcgc aatcctccca cctcagactc ccaaagtgct ggaattacag ttgggagcca     2520

ctgtgcctgg cctggaagac tttcaacttg tgtctcagtg cagttcttga ctcacctctc     2580

tgggcctcag gttctacaaa tgccagacac ctagcgaaga gctctgcagg ctttccactg     2640

cctgtattgg aaatcttgca attcacataa ttattcagtc actgcctggt acctttatct     2700

tcccatccca ctaatgttag tgttttttaa tggagctttt attctgagaa tatgtgtttg     2760

tctgtttgtt tgttttttga gacagagtct cactttgtca cccaggctgg agtgcagtgg     2820

cacgatctca gctcactgca agctctgcct ctcaggttca agtgattctc ctgcctcagc     2880

ctcctgagta gatgggactg taggcacctg ccactatgcc tggctaattt ttgtgttttt     2940

agtagagaca gggtttcacc atattggcca ggctggtctc gaactactga cctcgtgatc     3000

tgcccgcctt ggcctatcaa agtgttggga ttacaggctt gagccaccgc acccggccga     3060

gaatatgtgt tgttatttat gactggatta tgaagaatca ggagaatgca tttcatgtct     3120

gattctgctg ctaattaagt caatcattta atttttggga cctcagtttc tttgtaagta     3180

aaataacacc tgcttgttct tcatccctgg gctgttggga ggaacagatg agacagtggc     3240

tatagaagca cttggaaaat gcacttgtcc tgttttgtaa aataaaaagg tattaaatgt     3300

gtatttctgc catgtaccta atgattattc agtgcgtata tatctgaaaa gtcatgttgc     3360

aaatctttct gtgaaacaga tgctatttta aattcactgg gagaaatatc ctatttaaag     3420

taatctatag taatttcttt ttatataata aaaatatatt tgtaaagtc                 3469


<210>  88
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Ala Cys Tyr Ile Tyr Gln Leu Pro Ser Trp Val Leu Asp Asp Leu 
1               5                   10                  15      


Cys Arg Asn Met Asp Ala Leu Ser Glu Trp Asp Trp Met Glu Phe Ala 
            20                  25                  30          


Ser Tyr Val Ile Thr Asp Leu Thr Gln Leu Arg Lys Ile Lys Ser Met 
        35                  40                  45              


Glu Arg Val Gln Gly Val Ser Ile Thr Arg Glu Leu Leu Trp Trp Trp 
    50                  55                  60                  


Gly Met Arg Gln Ala Thr Val Gln Gln Leu Val Asp Leu Leu Cys Arg 
65                  70                  75                  80  


Leu Glu Leu Tyr Arg Ala Ala Gln Ile Ile Leu Asn Trp Lys Pro Ala 
                85                  90                  95      


Pro Glu Ile Arg Cys Pro Ile Pro Ala Phe Pro Asp Ser Val Lys Pro 
            100                 105                 110         


Glu Lys Pro Leu Ala Ala Ser Val Arg Lys Ala Glu Asp Glu Gln Glu 
        115                 120                 125             


Glu Gly Gln Pro Val Arg Met Ala Thr Phe Pro Gly Pro Gly Ser Ser 
    130                 135                 140                 


Pro Ala Arg Ala His Gln Pro Ala Phe Leu Gln Pro Pro Glu Glu Asp 
145                 150                 155                 160 


Ala Pro His Ser Leu Arg Ser Asp Leu Pro Thr Ser Ser Asp Ser Lys 
                165                 170                 175     


Asp Phe Ser Thr Ser Ile Pro Lys Gln Glu Lys Leu Leu Ser Leu Ala 
            180                 185                 190         


Gly Asp Ser Leu Phe Trp Ser Glu Ala Asp Val Val Gln Ala Thr Asp 
        195                 200                 205             


Asp Phe Asn Gln Asn Arg Lys Ile Ser Gln Gly Thr Phe Ala Asp Val 
    210                 215                 220                 


Tyr Arg Gly His Arg His Gly Lys Pro Phe Val Phe Lys Lys Leu Arg 
225                 230                 235                 240 


Glu Thr Ala Cys Ser Ser Pro Gly Ser Ile Glu Arg Phe Phe Gln Ala 
                245                 250                 255     


Glu Leu Gln Ile Cys Leu Arg Cys Cys His Pro Asn Val Leu Pro Val 
            260                 265                 270         


Leu Gly Phe Cys Ala Ala Arg Gln Phe His Ser Phe Ile Tyr Pro Tyr 
        275                 280                 285             


Met Ala Asn Gly Ser Leu Gln Asp Arg Leu Gln Gly Gln Gly Gly Ser 
    290                 295                 300                 


Asp Pro Leu Pro Trp Pro Gln Arg Val Ser Ile Cys Ser Gly Leu Leu 
305                 310                 315                 320 


Cys Ala Val Glu Tyr Leu His Gly Leu Glu Ile Ile His Ser Asn Val 
                325                 330                 335     


Lys Ser Ser Asn Val Leu Leu Asp Gln Asn Leu Thr Pro Lys Leu Ala 
            340                 345                 350         


His Pro Met Ala His Leu Cys Pro Val Asn Lys Arg Ser Lys Tyr Thr 
        355                 360                 365             


Met Met Lys Thr His Leu Leu Arg Thr Ser Ala Ala Tyr Leu Pro Glu 
    370                 375                 380                 


Asp Phe Ile Arg Val Gly Gln Leu Thr Lys Arg Val Asp Ile Phe Ser 
385                 390                 395                 400 


Cys Gly Ile Val Leu Ala Glu Val Leu Thr Gly Ile Pro Ala Met Asp 
                405                 410                 415     


Asn Asn Arg Ser Pro Val Tyr Leu Lys Asp Leu Leu Leu Ser Asp Ile 
            420                 425                 430         


Pro Ser Ser Thr Ala Ser Leu Cys Ser Arg Lys Thr Gly Val Glu Asn 
        435                 440                 445             


Val Met Ala Lys Glu Ile Cys Gln Lys Tyr Leu Glu Lys Gly Ala Gly 
    450                 455                 460                 


Arg Leu Pro Glu Asp Cys Ala Glu Ala Leu Ala Thr Ala Ala Cys Leu 
465                 470                 475                 480 


Cys Leu Arg Arg Arg Asn Thr Ser Leu Gln Glu Val Cys Gly Ser Val 
                485                 490                 495     


Ala Ala Val Glu Glu Arg Leu Arg Gly Arg Glu Thr Leu Leu Pro Trp 
            500                 505                 510         


Ser Gly Leu Ser Glu Gly Thr Gly Ser Ser Ser Asn Thr Pro Glu Glu 
        515                 520                 525             


Thr Asp Asp Val Asp Asn Ser Ser Leu Asp Ala Ser Ser Ser Met Ser 
    530                 535                 540                 


Val Ala Pro Trp Ala Gly Ala Ala Thr Pro Leu Leu Pro Thr Glu Asn 
545                 550                 555                 560 


Gly Glu Gly Arg Leu Arg Val Ile Val Gly Arg Glu Ala Asp Ser Ser 
                565                 570                 575     


Ser Glu Ala Cys Val Gly Leu Glu Pro Pro Gln Asp Val Thr Glu Thr 
            580                 585                 590         


Ser Trp Gln Ile Glu Ile Asn Glu Ala Lys Arg Lys Leu Met Glu Asn 
        595                 600                 605             


Ile Leu Leu Tyr Lys Glu Glu Lys Val Asp Ser Ile Glu Leu Phe Gly 
    610                 615                 620                 


Pro 
625 


<210>  89
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-sense miR-146a

<400>  89
aacccaugga auucaguucu ca                                                22


<210>  90
<211>  275
<212>  DNA
<213>  Homo sapiens

<400>  90
gtttacctga aggacttact cctcagaacg tgatggcaaa ggagatctgc gagatctgcc       60

agaagtacct ggagatgcgg aggcgtaaca ccagcctgca cgaggtcggg agacgttgct      120

ccctttgctc ccttggagtg ggctttctga tgggctttct gagggtacag gctctagggt      180

acaggctctt cttccaacac caccccagag gaaacagacg acgttctcca tgagtgtggc      240

accctgggca acttcgtggc aaattgagat caatg                                 275


<210>  91
<211>  275
<212>  DNA
<213>  Homo sapiens

<400>  91
aggagaatgc atttcatgtc tgatttcatg tctgattctg ctgctaatta atcatttaat       60

ttttgggacc tcagtaataa cacctgcttg ttcttcatcc ttcttcatcc ctgggctgtt      120

gggaggggag gaacagatga gacagtggct gacagtggct atagaagcac ttggaaatgc      180

acttgtcctg ttttgtaaaa gtatttctgc catgtaccta atgatgtacc taatgattat      240

tcagtgcgta gaaaagtcat gttgcaaatc tttct                                 275


<210>  92
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MiR-146a prob

<400>  92
aacccatgga attcagttct ca                                                22


<210>  93
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MiR-146a 5'primer

<400>  93
gtgccgagga gggatctaga a                                                 21


<210>  94
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MiR-146a 3'primer

<400>  94
cctgcacgct aaccctctct                                                   20


<210>  95
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MiR-146a 5'primer

<400>  95
cgactggagc acgaggacac tga                                               23


<210>  96
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MiR-146a 5'primer

<400>  96
ggacactgac atggactgaa ggagta                                            26


<210>  97
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MiR-146a 5'primer

<400>  97
ttcagctggg atatctctgt catcg                                             25


<210>  98
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MiR-146a 5'primer

<400>  98
gggcttgagg acctggagag agt                                               23


<210>  99
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MiR-146a 3'primer

<400>  99
gctgaggata cacatcggct tttc                                              24


<210>  100
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MiR-146a 3'primer

<400>  100
ctcctcgttg tgctactgtc tcctg                                             25


<210>  101
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MiR-146a 3'primer

<400>  101
gctgtcaacg atacgctacg taacg                                             25


<210>  102
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MiR-146a 3'primer

<400>  102
cgctacgtaa cggcatgaca gtg                                               23


<210>  103
<211>  275
<212>  DNA
<213>  Homo sapiens

<400>  103
agcgttacag ccctgcattt gagattaagt tgccttgatt ctgacatttg tggtgtgccg       60

caatgagagt caatcaatct ctattgacag cctgcttcag ccttctgtcc ttggaacagt      120

catataagat aggtcctact gcaaaccacc ctccatattt ccgtaccatt tacaagacat      180

ctttttaaac cactggagga ggattttact tatctgtgta ttcaccaagc atacttgcca      240

ttacttttcc ctctccaaca tcacattcac tttaa                                 275


<210>  104
<211>  275
<212>  DNA
<213>  Homo sapiens

<400>  104
tactccctca gcatcagagc atgcactctt ccctgacctt cacgaaggga ttcacgaagg       60

gatggctctc cagtcggtcc cgtagcacac agttacagtg atactgctat cattcttcgc      120

taattgcaca gcacctgcag cattgtaact cccaggcctt ggacatttag tgacttttag      180

tgactgttag ccggtccctt ggttcactgt cattgtgttt cccagtttct tcttgtttcc      240

ctgattatga gagcttccat tgttctgtta agtct                                 275


<210>  105
<211>  275
<212>  DNA
<213>  Homo sapiens

<400>  105
tatgtgtgtg gtacctgttg tgtccaagat acgctttcca tttgatgatg gagttgacat       60

ggaggcagtg cttgcttgct ttgttcgcct atcatctggc tggccacatg aggctgtcaa      120

gcaaaagtgt agttgagtag ctggttggcc aaatcacgct ggaaccttgg gcaaggagag      180

tgcctggatt tcatgtcagt aatagggtac catctaggtc agtttggaac aaaatcctct      240

ccttgtggaa ggaaatatcc catgcagttt gttga                                 275


<210>  106
<211>  275
<212>  DNA
<213>  Homo sapiens

<400>  106
tccctaacct acacccatag attacccaag gtttcagtgt actagttttg tttataccct       60

caatttctgg cctttttctg gcctttggct attttagcat gttaagcact gctttcagtt      120

ttaataatat ccaccttgag gggtcgctgc ggatgttact taatgtggct tctctgtggc      180

ttctctaatg tagtttcttt agtttctttg attaccgact acacaagtac catgtgattt      240

aattctccat attctccatt cctccaatgt aactc                                 275


<210>  107
<211>  275
<212>  DNA
<213>  Homo sapiens

<400>  107
agaaaaccac acttctcata ccttcttccc caaagccaga agatgcacaa tccttccaag       60

gtccaccgtg attaatgatt aacatccaca gcgagacctc accctcttct tgaactggtg      120

ctgtcgctgt ctgggcttca tagcattcgc gccaagtgcc tgaacatctg ggcccatctg      180

ggccctgatt ctgggcatcc gggcatcctc atgaccattg gattcatcct gttactggta      240

ttcggctctg tgcactccac tgtgcaatgc tggcc                                 275


<210>  108
<211>  275
<212>  DNA
<213>  Homo sapiens

<400>  108
tcaacaccct cttcttgaac tggtgttctt gaactggtgc tgtctgggct acagtctacc       60

atattatgtt acagatacag ataatacagg aaaaacgggg caacctttgc actccactgt      120

gcaatacctt tgcactccac tgtgcaatgc tgcactccac tgtgcaatgc tggcccccac      180

acacctgtct acagtgtcat cacacacctg tctacagtgt cattccacac ctgtctacag      240

tgtcattcaa cacctgtcta cagtgtcatt caata                                 275


<210>  109
<211>  275
<212>  DNA
<213>  Homo sapiens

<400>  109
ggtcttcgct ggacaccatg aatcaatgaa tcacactgtc caaaccttct ttctctcctg       60

tcaacagtgg ccagcagccc cccaactatg agatgctcaa tgttcaacac cctcttcatg      120

aacccattcg cctactccgt gaagtctagg gccaagtgcc tgaacatctg ggcccatctg      180

ggccctgatt ctgggcatcc catgaccatt ctgctcatcg tcatcgcatc actgaggcca      240

ggagctctgc tcctcacacg cttttctaca atggc                                 275


<210>  110
<211>  275
<212>  DNA
<213>  Homo sapiens

<400>  110
cagctgcgct acacggagga actgctgcgc tacacggagg aactgctgcg cccggcgcat       60

gggcaagtgc aaggtcccca tcttcgactt cagagtcttc gctgtgccga gtgcacctag      120

agggctgcac ctagagggca cgcagcgtga acgcagcgtg agggtgtgtc ttccccaaca      180

gcctctatga cgacatcgag tatgacgaca tcgagtgctt ccttagacat cgagtgcttc      240

cttatggagc cgagtgcttc cttatggagc tggag                                 275


<210>  111
<211>  275
<212>  DNA
<213>  Homo sapiens

<400>  111
tggcgggcaa cgaattccag gtgtcagctc catgtcggtg tcagagctga tgaaggcgca       60

gatcacccag aagattgctg gtggtggaca aatgcgacga gtggacaaat gcgacgaacc      120

tctgaggaat aacaagggcc gcagcagcac agcaagtgag cgggctggag ggtgtgaggg      180

tgtgcaggac gacctgttct ctggctgacc ttcgagggga agcccccctg agcaccgtgt      240

tcatgaatct agcaccgtgt tcatgaatct gcgcc                                 275


<210>  112
<211>  275
<212>  DNA
<213>  Homo sapiens

<400>  112
gttgaggatc tcttactctc taagcgccac ggaattaacc cgagcaggca tctcacctca       60

tcagcagtga ccagtccaaa gtggtcaggg tggcctctgg ccctggccag gattgctaca      120

gttgtttgga ggagttgtgg ccatggcggc caagatgatg tccgcggcgg ccattccaat      180

gggggtggag ttgcctcggg gactctccgg attgaccaag ttcattctgc cattgcggct      240

gtcattgcga gagccaacta tcccaaatat acctg                                 275


<210>  113
<211>  275
<212>  DNA
<213>  Homo sapiens

<400>  113
ttattagtgc gctgtgaggt ctccatctcc acccgctttg acatgggtag ttcggaggga       60

gggttttcag ccacgtgcag gggtatagct tgccctcact ttgccctcac ttgctcaaaa      120

acaactcctt gccctgttct caataacatg gaggtcactt actatttctt cctgtcacac      180

gttccatgct ttttcagaaa gttgcagcag ctattttgcc agttagccag ttagtatacc      240

tctttgttgt tttgttgtac tttcttgggc ttttg                                 275


<210>  114
<211>  275
<212>  DNA
<213>  Homo sapiens

<400>  114
tgccagctct attcaatact tctccaatac ttctcctctc agatgatagt ctctttctga       60

catctcggtg gttagggtgg ttagcaatta ttcctctgag tcctctgagt gggagctgga      120

ccctgagctg gaccctgtaa aggatgttct aggatgttct aattctttct gctcttctaa      180

ttctttctgc tctgagacga gctctgagac gaatgctatg ggctggaatg ctatgggctg      240

cagatgactt ctgcagatga cttcttagag gattt                                 275


<210>  115
<211>  250
<212>  DNA
<213>  Homo sapiens

<400>  115
cctgctaagg gatgcccctt caggcggatg ccccttcagg cataggcagt gcataggcag       60

tattttcctg tcagcttcct gtcagcatct gagcttgagg agtgaggaaa tgggccaggg      120

cgcagagtcc cagagagctc ctctctaact agctcctctc taactcagag caactgaagc      180

ctgcagtggt ggttgtgacg gcccaacctg ggattgctga gcagggaagc tttgcatgtt      240

gctctaaggt                                                             250


<210>  116
<211>  275
<212>  DNA
<213>  Homo sapiens

<400>  116
aattccaagg ccaagtcctg caggagtcct gcaggactgg ttgggtctgg gttgggtctg       60

gggatctatg gcatccaaga cagtgacact ctcatcctct acactctcat cctctcgaag      120

aagaaaggct ctgtttccag ccagttagtt tgggagactt ctctgtacat ttctgatttc      180

tgccatgtac tccagaactc ccagaactca tcctgtcaat cactctccca ggtcttcacc      240

agttttacaa caatgagtta tcccaggcca gacgt                                 275


<210>  117
<211>  275
<212>  DNA
<213>  Homo sapiens

<400>  117
aatttcgtga aacatcggcc aactatcctg cgcctggtga aacactggta ccccaccctc       60

aacgtggcag aagggatggg acatcgttgc tcagagggcc gacaacaggg agaaccccat      120

ctccaggcac gagacatcca cttgacagtg ggagcagagg ggttacccag atttccccag      180

atttcaacct catcgtgaac tcatcgtgaa cccttatgag cccattgtcc ttccaggttc      240

ctggcagtga atcctgatgg tgggagctac gccta                                 275


<210>  118
<211>  275
<212>  DNA
<213>  Homo sapiens

<400>  118
atttcactca taacaatctt accctcaatc ttaccctttc ttgcaagaga tttcctaata       60

ccttggtttc actagtcctc tgccccttaa aagattgaag gaaacttgtc aactcatatc      120

cacgtaactc atatccacgt tatctagcaa tgttggttta ccagtgacac cccatgacac      180

cccatattca tcacaaaatt tgaggtcaaa ttttatcttt tcactttcac ttacaagctc      240

tatgatctta gactatatct aattcctctg atcac                                 275


<210>  119
<211>  275
<212>  DNA
<213>  Homo sapiens

<400>  119
aaaaagccca catttgaggt ggctctggct catctagacc tggcaagaat atttctacta       60

tggtcggttt caggagacgt caatgcaatt atccattatt tctggaaagc ttgagcctcc      120

ttgggcctcc ttgggttcgt ctataaattg tgaagccctg gagtactatg agcgggagaa      180

ctctgtgaga caaggtcctt caaggtcctt aggcacccag atatcccaga tatcagccac      240

tttcacattt tttactaatc atcttttctg cttac                                 275


<210>  120
<211>  275
<212>  DNA
<213>  Homo sapiens

<400>  120
tccgagccag gtcaggcttc ggagggtggc agaggggcca ctacccaagg cccaaggtct       60

agctaggccc aagacccaag acctagttac ccagacagtg catgtatcac atgtcttcag      120

aagcatcatg taaccgagtg tcctcttgcg gtcctcttgc gtgtccaaaa gtagcggctg      180

tagcacaggc ttcacagtga gtgattttgt gttcagccgt gagtctcagc cgtgagtcac      240

actacatgcc gtgacgtcca ggttgtcctt gagta                                 275


<210>  121
<211>  275
<212>  DNA
<213>  Homo sapiens

<400>  121
aaaaggaggc ctcctatgac ccaggtccta cgtgtccagc actggcagag ggcagcgcca       60

tcaggagcca gtgcctgacg agagcctagg cggcctctct tgcgctcctg gcacttgact      120

ccaagacagc cgtggaagga ctggcccttg gcagctctgc atcatcgtcg tcagatcgtc      180

agagccaccg cagattatca tgcccgacag aagatggtcc agaagtcaga gctgatgtgt      240

tcacctgggc tgatgtgttc acctgggcag atccc                                 275


