                         SEQUENCE LISTING

<110>  THE UNIVERSITY OF MANCHESTER
       NATIONAL INSTITUTE ON AGING
       UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED
       VU UNIVERSITY MEDICAL CENTER AMSTERDAM
       UCL BUSINESS PLC
 
<120>  TESTS AND TREATMENT

<130>  P137820WO

<150>  US61/529531
<151>  2011-08-31

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  3794
<212>  DNA
<213>  Homo sapiens

<400>  1
agcttgggct gaaattgtgc aggcgtctcc acacccccat ctcatcccgc atgatctcct       60

cgccggcagg gaccgtctcg ggttcctagc gaaccccgac ttggtccgca gaagccgcgc      120

gccgcccacc ctccggcctt cccccaggcg aggcctctca gtacccgagg ctcccttttc      180

tcgagcccgc agcggcagcg ctcccagcgg gtccccggga aggagacagc tcgggtactg      240

agggcgggaa agcaaggaag aggccagatc cccatccctt gtccctgcgc cgccgccgcc      300

gccgccgccg ccgggaagcc cggggcccgg atgcaggcaa ttccaccagt cgctagaggc      360

gaaagcccga cacccagctt cggtcagaga aatgagaggg aaagtaaaaa tgcgtcgagc      420

tctgaggaga gcccccgctt ctacccgcgc ctcttcccgg cagccgaacc ccaaacagcc      480

acccgccagg atgccgcctc ctcactcacc cactcgccac cgcctgcgcc tccgccgccg      540

cgggcgcagg caccgcaacc gcagccccgc cccgggcccg cccccgggcc cgccccgacc      600

acgccccggc cccggccccg gcccctagcg cgcgactcct gagttccaga gcttgctaca      660

ggctgcggtt gtttccctcc ttgttttctt ctggttaatc tttatcaggt cttttcttgt      720

tcaccctcag cgagtactgt gagagcaagt agtggggaga gagggtggga aaaacaaaaa      780

cacacacctc ctaaacccac acctgctctt gctagacccc gcccccaaaa gagaagcaac      840

cgggcagcag ggacggctga cacaccaagc gtcatctttt acgtgggcgg aacttgtcgc      900

tgtttgacgc acctctcttt cctagcggga caccgtaggt tacgtctgtc tgttttctat      960

gtgcgatgac gttttctcac gaggctagcg aaatggggcg gggcaacttg tcctgttctt     1020

ttatcttaag acccgctctg gaggagcgtt ggcgcaatag cgtgtgcgaa ccttaatagg     1080

ggaggctgct ggatctggag aaagtgaaga cgatttcgtg gttttgaatg gttttgtttg     1140

tgcttggtag gcagtgggcg ctcaacacat aattggtgga tgaaattttg tttttaccgt     1200

aagacactgt taagtgcatt caaaactcca ctgcaaaccc tggtagggga cagctccggc     1260

actgcgggcg ggaatcccac ggtcccctgc aaagtcatcg caattttgcc tttacatgta     1320

agaattctct caagcatgat tttcacactg gggaatgtca tttttgctag ttgcaatatg     1380

tggatgagtt gttttttttt aacttttgaa aaacgtacca ttctgtttga tgtgtaaaaa     1440

acacaaagat ttttgaaacc ttgcgtcttt tggtctgcag gtgtatagat tccacttact     1500

acagatgagt agcatttaca ccactcagat gtgtaaaaaa acaaaggttt tttaaactgt     1560

gtgccttttg atctgcaagt gtgagatggc acttactaca gtgagtagca tttaatcttt     1620

ttcatcacta aaaatcacac agaacgtttt aatcattcac cgaggaagaa agggaggaat     1680

aaatacacaa aatggctctc aacgtctaca ccttctgcag aaacagaccc ttttcctact     1740

gttctatgct ttgtgaaagt tgatcataca aattgggtca ttctttttat acccaactaa     1800

aatagtgggg gtagggggta gaaaagcact taggacaaat gacactgctc ccacagtgta     1860

attctctcca agtccagctg ctgcaactgc ccgttgtgac ctgagaccag ttttatctaa     1920

tagttgctaa aatgacctgc tgcagctcta attttatcta ccaccatcac tcaccagttg     1980

aaactcacca gctcctcaga tccttaatag tgccaatgaa ttttctcaaa gagcactatg     2040

taacatttct cttttttaac aaaacctccc ccttttcttt gttgtgtgga tataccgaag     2100

accatctgat ctacatgtat gccctaattg caattctttc ttcccaaata aatcacttaa     2160

tttagagatt catctctgta tttttatttt gactgacagc ttataacaag tagctagcat     2220

ttaccaagtt tctacactga gttgtacttc acttatacgt ggaattaaaa aacaactgaa     2280

tttatagaaa cagagtagac ccttggttgg ggggcttggg gggaaagaaa attgtagggt     2340

agggtacaaa gttgcagtta cgtctaatac atctagagat ttaatgtaca acatgaggac     2400

tagcgttaat aattgtgtta gtccattctt acactgctat aaagaaataa ctgaaactgg     2460

gtaatttata aagaaaagtt taatggctca cagttctgca ggctgtacaa gaagcatggc     2520

tggatcagct tctgggcagg ccatagggaa cttaaaatca tgatggaagg catagggaga     2580

ccccagactt cacatggcag gaactggggg aagagagaaa tgggaggtgc tacatacgtt     2640

taaacaacta gatcttgtca gaactcacta tatagtacca agaggggact gtacaaaacc     2700

attagaagcc accccataat ccactcacct cccaccaggc ccaacctcca acactgggga     2760

ttacagttga acatgagatt tgggtgggga cagagatcca aaccatgtta ttccaactct     2820

ggcccctccc aaatctaatg tccttctcat attgcaaaat actgtcgtgc cttaccaaca     2880

gttccccaaa gtcttaactc gatccagcat tcattcaaaa gtccaaagtc ccaagtctca     2940

cctgagacga agctagtccc ttctacctat gaacctgtaa aatcaaaaac aaggtaattg     3000

cttcaaagat acaatggggg tataggcatt gggcagatac tgccattccg aaagggagaa     3060

atctgccaaa agaaagaggc tatagggccc cattgcaagt ctgaaagcca gccgggcagt     3120

cattaaatgt taaagctctg aaataatctc ctttgactca cacccaggga acactgatgc     3180

aatgagtggg ctcccaaaac cttgggcaga accacccctg tggttttcca gggttcatct     3240

cccacagctg ctctcatggg ctagcattga gtgcttgcag cttttccagg ctgcagggtg     3300

caagttgttg gtggatctac cattctgggg tctggaggac ggtggctgtc ttgtcatagc     3360

tctgctaggc agtgccccag gggactctct gtgggggctg caaccccaca tttcttctcc     3420

ttgcttccct agtagatgtt ctccatgagg attccacccc agtaacaggc ttctgtctgg     3480

acatccaggc tttttcatac atcctctaaa atctaggcag agcttcttaa gcctcaactc     3540

ttgcattatg tgcgcccgcc ggcttcacag cttatggaag ccaccaaggc ttatgcctgg     3600

caccctgtga agcagcagcc tgaactgtat tcttactggt gaaagttatc tgagttacca     3660

gctgcaaatc catgtgggtc tgcagcaacc tcaattcttg cctcctcaga agaaagaatt     3720

tgaccaagag gcataaggca gaaaaagaga ctgcgacaag tttcagagca ggagtaaaag     3780

tttattaaaa agct                                                       3794


<210>  2
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Thr Leu Cys Pro Pro Pro Ser Pro Ala Val Ala Lys Thr Glu 
1               5                   10                  15      


Ile Ala Leu Ser Gly Lys Ser Pro Leu Leu Ala Ala Thr Phe Ala Tyr 
            20                  25                  30          


Trp Asp Asn Ile Leu Gly Pro Arg Val Arg His Ile Trp Ala Pro Lys 
        35                  40                  45              


Thr Glu Gln Val Leu Leu Ser Asp Gly Glu Ile Thr Phe Leu Ala Asn 
    50                  55                  60                  


His Thr Leu Asn Gly Glu Ile Leu Arg Asn Ala Glu Ser Gly Ala Ile 
65                  70                  75                  80  


Asp Val Lys Phe Phe Val Leu Ser Glu Lys Gly Val Ile Ile Val Ser 
                85                  90                  95      


Leu Ile Phe Asp Gly Asn Trp Asn Gly Asp Arg Ser Thr Tyr Gly Leu 
            100                 105                 110         


Ser Ile Ile Leu Pro Gln Thr Glu Leu Ser Phe Tyr Leu Pro Leu His 
        115                 120                 125             


Arg Val Cys Val Asp Arg Leu Thr His Ile Ile Arg Lys Gly Arg Ile 
    130                 135                 140                 


Trp Met His Lys Glu Arg Gln Glu Asn Val Gln Lys Ile Ile Leu Glu 
145                 150                 155                 160 


Gly Thr Glu Arg Met Glu Asp Gln Gly Gln Ser Ile Ile Pro Met Leu 
                165                 170                 175     


Thr Gly Glu Val Ile Pro Val Met Glu Leu Leu Ser Ser Met Lys Ser 
            180                 185                 190         


His Ser Val Pro Glu Glu Ile Asp Ile Ala Asp Thr Val Leu Asn Asp 
        195                 200                 205             


Asp Asp Ile Gly Asp Ser Cys His Glu Gly Phe Leu Leu Asn Ala Ile 
    210                 215                 220                 


Ser Ser His Leu Gln Thr Cys Gly Cys Ser Val Val Val Gly Ser Ser 
225                 230                 235                 240 


Ala Glu Lys Val Asn Lys Ile Val Arg Thr Leu Cys Leu Phe Leu Thr 
                245                 250                 255     


Pro Ala Glu Arg Lys Cys Ser Arg Leu Cys Glu Ala Glu Ser Ser Phe 
            260                 265                 270         


Lys Tyr Glu Ser Gly Leu Phe Val Gln Gly Leu Leu Lys Asp Ser Thr 
        275                 280                 285             


Gly Ser Phe Val Leu Pro Phe Arg Gln Val Met Tyr Ala Pro Tyr Pro 
    290                 295                 300                 


Thr Thr His Ile Asp Val Asp Val Asn Thr Val Lys Gln Met Pro Pro 
305                 310                 315                 320 


Cys His Glu His Ile Tyr Asn Gln Arg Arg Tyr Met Arg Ser Glu Leu 
                325                 330                 335     


Thr Ala Phe Trp Arg Ala Thr Ser Glu Glu Asp Met Ala Gln Asp Thr 
            340                 345                 350         


Ile Ile Tyr Thr Asp Glu Ser Phe Thr Pro Asp Leu Asn Ile Phe Gln 
        355                 360                 365             


Asp Val Leu His Arg Asp Thr Leu Val Lys Ala Phe Leu Asp Gln Val 
    370                 375                 380                 


Phe Gln Leu Lys Pro Gly Leu Ser Leu Arg Ser Thr Phe Leu Ala Gln 
385                 390                 395                 400 


Phe Leu Leu Val Leu His Arg Lys Ala Leu Thr Leu Ile Lys Tyr Ile 
                405                 410                 415     


Glu Asp Asp Thr Gln Lys Gly Lys Lys Pro Phe Lys Ser Leu Arg Asn 
            420                 425                 430         


Leu Lys Ile Asp Leu Asp Leu Thr Ala Glu Gly Asp Leu Asn Ile Ile 
        435                 440                 445             


Met Ala Leu Ala Glu Lys Ile Lys Pro Gly Leu His Ser Phe Ile Phe 
    450                 455                 460                 


Gly Arg Pro Phe Tyr Thr Ser Val Gln Glu Arg Asp Val Leu Met Thr 
465                 470                 475                 480 


Phe 
    


<210>  3
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Thr Leu Cys Pro Pro Pro Ser Pro Ala Val Ala Lys Thr Glu 
1               5                   10                  15      


Ile Ala Leu Ser Gly Lys Ser Pro Leu Leu Ala Ala Thr Phe Ala Tyr 
            20                  25                  30          


Trp Asp Asn Ile Leu Gly Pro Arg Val Arg His Ile Trp Ala Pro Lys 
        35                  40                  45              


Thr Glu Gln Val Leu Leu Ser Asp Gly Glu Ile Thr Phe Leu Ala Asn 
    50                  55                  60                  


His Thr Leu Asn Gly Glu Ile Leu Arg Asn Ala Glu Ser Gly Ala Ile 
65                  70                  75                  80  


Asp Val Lys Phe Phe Val Leu Ser Glu Lys Gly Val Ile Ile Val Ser 
                85                  90                  95      


Leu Ile Phe Asp Gly Asn Trp Asn Gly Asp Arg Ser Thr Tyr Gly Leu 
            100                 105                 110         


Ser Ile Ile Leu Pro Gln Thr Glu Leu Ser Phe Tyr Leu Pro Leu His 
        115                 120                 125             


Arg Val Cys Val Asp Arg Leu Thr His Ile Ile Arg Lys Gly Arg Ile 
    130                 135                 140                 


Trp Met His Lys Glu Arg Gln Glu Asn Val Gln Lys Ile Ile Leu Glu 
145                 150                 155                 160 


Gly Thr Glu Arg Met Glu Asp Gln Gly Gln Ser Ile Ile Pro Met Leu 
                165                 170                 175     


Thr Gly Glu Val Ile Pro Val Met Glu Leu Leu Ser Ser Met Lys Ser 
            180                 185                 190         


His Ser Val Pro Glu Glu Ile Asp Ile Ala Asp Thr Val Leu Asn Asp 
        195                 200                 205             


Asp Asp Ile Gly Asp Ser Cys His Glu Gly Phe Leu Leu Asn 
    210                 215                 220         


<210>  4
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  4
agtcgctaga ggcgaaagc                                                    19


<210>  5
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  5
tacgcatccc agtttgagac gggggccggg gccggggccg ggg                         43


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  6
tacgcatccc agtttgagac g                                                 21


<210>  7
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  7
ggccccggcc ccggccccgg cc                                                22


<210>  8
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  8
gaaatcacac agtgttcctg aagaa                                             25


<210>  9
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  9
agctgatggc attgagaaga aag                                               23


<210>  10
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  10
cctgttcgac agtcagccg                                                    19


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  11
cgaccaaatc cgttgactcc                                                   20


<210>  12
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  12
atctgcttca tccagctttt atga                                              24


