                         SEQUENCE LISTING

<110>  Max-Planck-Gesellschaft zur Frderung der Wissenschaften 
       e.V.
 
<120>  LABELED PHOSPHATASES FOR THE SCREENING OF INHIBITORS

<130>  T1081 PCT

<150>  EP 11 00 7082.8
<151>  2011-08-31

<150>  US 61/529,476
<151>  2011-08-31

<160>  8     

<170>  PatentIn version 3.4

<210>  1
<211>  435
<212>  PRT
<213>  homo sapiens

<400>  1

Met Glu Met Glu Lys Glu Phe Glu Gln Ile Asp Lys Ser Gly Ser Trp 
1               5                   10                  15      


Ala Ala Ile Tyr Gln Asp Ile Arg His Glu Ala Ser Asp Phe Pro Cys 
            20                  25                  30          


Arg Val Ala Lys Leu Pro Lys Asn Lys Asn Arg Asn Arg Tyr Arg Asp 
        35                  40                  45              


Val Ser Pro Phe Asp His Ser Arg Ile Lys Leu His Gln Glu Asp Asn 
    50                  55                  60                  


Asp Tyr Ile Asn Ala Ser Leu Ile Lys Met Glu Glu Ala Gln Arg Ser 
65                  70                  75                  80  


Tyr Ile Leu Thr Gln Gly Pro Leu Pro Asn Thr Cys Gly His Phe Trp 
                85                  90                  95      


Glu Met Val Trp Glu Gln Lys Ser Arg Gly Val Val Met Leu Asn Arg 
            100                 105                 110         


Val Met Glu Lys Gly Ser Leu Lys Cys Ala Gln Tyr Trp Pro Gln Lys 
        115                 120                 125             


Glu Glu Lys Glu Met Ile Phe Glu Asp Thr Asn Leu Lys Leu Thr Leu 
    130                 135                 140                 


Ile Ser Glu Asp Ile Lys Ser Tyr Tyr Thr Val Arg Gln Leu Glu Leu 
145                 150                 155                 160 


Glu Asn Leu Thr Thr Gln Glu Thr Arg Glu Ile Leu His Phe His Tyr 
                165                 170                 175     


Thr Thr Trp Pro Asp Phe Gly Val Pro Glu Ser Pro Ala Ser Phe Leu 
            180                 185                 190         


Asn Phe Leu Phe Lys Val Arg Glu Ser Gly Ser Leu Ser Pro Glu His 
        195                 200                 205             


Gly Pro Val Val Val His Cys Ser Ala Gly Ile Gly Arg Ser Gly Thr 
    210                 215                 220                 


Phe Cys Leu Ala Asp Thr Cys Leu Leu Leu Met Asp Lys Arg Lys Asp 
225                 230                 235                 240 


Pro Ser Ser Val Asp Ile Lys Lys Val Leu Leu Glu Met Arg Lys Phe 
                245                 250                 255     


Arg Met Gly Leu Ile Gln Thr Ala Asp Gln Leu Arg Phe Ser Tyr Leu 
            260                 265                 270         


Ala Val Ile Glu Gly Ala Lys Phe Ile Met Gly Asp Ser Ser Val Gln 
        275                 280                 285             


Asp Gln Trp Lys Glu Leu Ser His Glu Asp Leu Glu Pro Pro Pro Glu 
    290                 295                 300                 


His Ile Pro Pro Pro Pro Arg Pro Pro Lys Arg Ile Leu Glu Pro His 
305                 310                 315                 320 


Asn Gly Lys Cys Arg Glu Phe Phe Pro Asn His Gln Trp Val Lys Glu 
                325                 330                 335     


Glu Thr Gln Glu Asp Lys Asp Cys Pro Ile Lys Glu Glu Lys Gly Ser 
            340                 345                 350         


Pro Leu Asn Ala Ala Pro Tyr Gly Ile Glu Ser Met Ser Gln Asp Thr 
        355                 360                 365             


Glu Val Arg Ser Arg Val Val Gly Gly Ser Leu Arg Gly Ala Gln Ala 
    370                 375                 380                 


Ala Ser Pro Ala Lys Gly Glu Pro Ser Leu Pro Glu Lys Asp Glu Asp 
385                 390                 395                 400 


His Ala Leu Ser Tyr Trp Lys Pro Phe Leu Val Asn Met Cys Val Ala 
                405                 410                 415     


Thr Val Leu Thr Ala Gly Ala Tyr Leu Cys Tyr Arg Phe Leu Phe Asn 
            420                 425                 430         


Ser Asn Thr 
        435 


<210>  2
<211>  415
<212>  PRT
<213>  homo sapiens

<400>  2

Met Pro Thr Thr Ile Glu Arg Glu Phe Glu Glu Leu Asp Thr Gln Arg 
1               5                   10                  15      


Arg Trp Gln Pro Leu Tyr Leu Glu Ile Arg Asn Glu Ser His Asp Tyr 
            20                  25                  30          


Pro His Arg Val Ala Lys Phe Pro Glu Asn Arg Asn Arg Asn Arg Tyr 
        35                  40                  45              


Arg Asp Val Ser Pro Tyr Asp His Ser Arg Val Lys Leu Gln Asn Ala 
    50                  55                  60                  


Glu Asn Asp Tyr Ile Asn Ala Ser Leu Val Asp Ile Glu Glu Ala Gln 
65                  70                  75                  80  


Arg Ser Tyr Ile Leu Thr Gln Gly Pro Leu Pro Asn Thr Cys Cys His 
                85                  90                  95      


Phe Trp Leu Met Val Trp Gln Gln Lys Thr Lys Ala Val Val Met Leu 
            100                 105                 110         


Asn Arg Ile Val Glu Lys Glu Ser Val Lys Cys Ala Gln Tyr Trp Pro 
        115                 120                 125             


Thr Asp Asp Gln Glu Met Leu Phe Lys Glu Thr Gly Phe Ser Val Lys 
    130                 135                 140                 


Leu Leu Ser Glu Asp Val Lys Ser Tyr Tyr Thr Val His Leu Leu Gln 
145                 150                 155                 160 


Leu Glu Asn Ile Asn Ser Gly Glu Thr Arg Thr Ile Ser His Phe His 
                165                 170                 175     


Tyr Thr Thr Trp Pro Asp Phe Gly Val Pro Glu Ser Pro Ala Ser Phe 
            180                 185                 190         


Leu Asn Phe Leu Phe Lys Val Arg Glu Ser Gly Ser Leu Asn Pro Asp 
        195                 200                 205             


His Gly Pro Ala Val Ile His Cys Ser Ala Gly Ile Gly Arg Ser Gly 
    210                 215                 220                 


Thr Phe Ser Leu Val Asp Thr Cys Leu Val Leu Met Glu Lys Gly Asp 
225                 230                 235                 240 


Asp Ile Asn Ile Lys Gln Val Leu Leu Asn Met Arg Lys Tyr Arg Met 
                245                 250                 255     


Gly Leu Ile Gln Thr Pro Asp Gln Leu Arg Phe Ser Tyr Met Ala Ile 
            260                 265                 270         


Ile Glu Gly Ala Lys Cys Ile Lys Gly Asp Ser Ser Ile Gln Lys Arg 
        275                 280                 285             


Trp Lys Glu Leu Ser Lys Glu Asp Leu Ser Pro Ala Phe Asp His Ser 
    290                 295                 300                 


Pro Asn Lys Ile Met Thr Glu Lys Tyr Asn Gly Asn Arg Ile Gly Leu 
305                 310                 315                 320 


Glu Glu Glu Lys Leu Thr Gly Asp Arg Cys Thr Gly Leu Ser Ser Lys 
                325                 330                 335     


Met Gln Asp Thr Met Glu Glu Asn Ser Glu Ser Ala Leu Arg Lys Arg 
            340                 345                 350         


Ile Arg Glu Asp Arg Lys Ala Thr Thr Ala Gln Lys Val Gln Gln Met 
        355                 360                 365             


Lys Gln Arg Leu Asn Glu Asn Glu Arg Lys Arg Lys Arg Trp Leu Tyr 
    370                 375                 380                 


Trp Gln Pro Ile Leu Thr Lys Met Gly Phe Met Ser Val Ile Leu Val 
385                 390                 395                 400 


Gly Ala Phe Val Gly Trp Thr Leu Phe Phe Gln Gln Asn Ala Leu 
                405                 410                 415 


<210>  3
<211>  276
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  3

Met Ala Val Arg Glu Leu Pro Gly Ala Trp Asn Phe Arg Asp Val Ala 
1               5                   10                  15      


Asp Thr Ala Thr Ala Leu Arg Pro Gly Arg Leu Phe Arg Ser Ser Glu 
            20                  25                  30          


Leu Ser Arg Leu Asp Asp Ala Gly Arg Ala Thr Leu Arg Arg Leu Gly 
        35                  40                  45              


Ile Thr Asp Val Ala Asp Leu Arg Ser Ser Arg Glu Val Ala Arg Arg 
    50                  55                  60                  


Gly Pro Gly Arg Val Pro Asp Gly Ile Asp Val His Leu Leu Pro Phe 
65                  70                  75                  80  


Pro Asp Leu Ala Asp Asp Asp Ala Asp Asp Ser Ala Pro His Glu Thr 
                85                  90                  95      


Ala Phe Lys Arg Leu Leu Thr Asn Asp Gly Ser Asn Gly Glu Ser Gly 
            100                 105                 110         


Glu Ser Ser Gln Ser Ile Asn Asp Ala Ala Thr Arg Tyr Met Thr Asp 
        115                 120                 125             


Glu Tyr Arg Gln Phe Pro Thr Arg Asn Gly Ala Gln Arg Ala Leu His 
    130                 135                 140                 


Arg Val Val Thr Leu Leu Ala Ala Gly Arg Pro Val Leu Thr His Cys 
145                 150                 155                 160 


Phe Ala Gly Lys Asp Arg Thr Gly Phe Val Val Ala Leu Val Leu Glu 
                165                 170                 175     


Ala Val Gly Leu Asp Arg Asp Val Ile Val Ala Asp Tyr Leu Arg Ser 
            180                 185                 190         


Asn Asp Ser Val Pro Gln Leu Arg Ala Arg Ile Ser Glu Met Ile Gln 
        195                 200                 205             


Gln Arg Phe Asp Thr Glu Leu Ala Pro Glu Val Val Thr Phe Thr Lys 
    210                 215                 220                 


Ala Arg Leu Ser Asp Gly Val Leu Gly Val Arg Ala Glu Tyr Leu Ala 
225                 230                 235                 240 


Ala Ala Arg Gln Thr Ile Asp Glu Thr Tyr Gly Ser Leu Gly Gly Tyr 
                245                 250                 255     


Leu Arg Asp Ala Gly Ile Ser Gln Ala Thr Val Asn Arg Met Arg Gly 
            260                 265                 270         


Val Leu Leu Gly 
        275     


<210>  4
<211>  595
<212>  PRT
<213>  homo sapiens

<400>  4

Met Val Arg Trp Phe His Arg Asp Leu Ser Gly Leu Asp Ala Glu Thr 
1               5                   10                  15      


Leu Leu Lys Gly Arg Gly Val His Gly Ser Phe Leu Ala Arg Pro Ser 
            20                  25                  30          


Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Val Arg Val Gly Asp Gln 
        35                  40                  45              


Val Thr His Ile Arg Ile Gln Asn Ser Gly Asp Phe Tyr Asp Leu Tyr 
    50                  55                  60                  


Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Leu Val Glu Tyr Tyr Thr 
65                  70                  75                  80  


Gln Gln Gln Gly Val Leu Gln Asp Arg Asp Gly Thr Ile Ile His Leu 
                85                  90                  95      


Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Ser Glu Arg Trp Tyr His 
            100                 105                 110         


Gly His Met Ser Gly Gly Gln Ala Glu Thr Leu Leu Gln Ala Lys Gly 
        115                 120                 125             


Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Leu Ser Gln Pro Gly Asp 
    130                 135                 140                 


Phe Val Leu Ser Val Leu Ser Asp Gln Pro Lys Ala Gly Pro Gly Ser 
145                 150                 155                 160 


Pro Leu Arg Val Thr His Ile Lys Val Met Cys Glu Gly Gly Arg Tyr 
                165                 170                 175     


Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Leu Thr Asp Leu Val Glu 
            180                 185                 190         


His Phe Lys Lys Thr Gly Ile Glu Glu Ala Ser Gly Ala Phe Val Tyr 
        195                 200                 205             


Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val Asn Ala Ala Asp Ile Glu 
    210                 215                 220                 


Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Glu Ser Glu Asp Thr Ala 
225                 230                 235                 240 


Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Leu Gln Lys Gln Glu Val 
                245                 250                 255     


Lys Asn Leu His Gln Arg Leu Glu Gly Gln Arg Pro Glu Asn Lys Gly 
            260                 265                 270         


Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe Asp His Ser Arg Val Ile 
        275                 280                 285             


Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Ser Asp Tyr Ile Asn Ala 
    290                 295                 300                 


Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro Asp Glu Asn Ala Lys Thr 
305                 310                 315                 320 


Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Thr Val Asn Asp Phe Trp 
                325                 330                 335     


Gln Met Ala Trp Gln Glu Asn Ser Arg Val Ile Val Met Thr Thr Arg 
            340                 345                 350         


Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pro Tyr Trp Pro Glu Val 
        355                 360                 365             


Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Val Thr Asn Cys Gly Glu 
    370                 375                 380                 


His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Leu Gln Val Ser Pro Leu 
385                 390                 395                 400 


Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp His Tyr Gln Tyr Leu Ser 
                405                 410                 415     


Trp Pro Asp His Gly Val Pro Ser Glu Pro Gly Gly Val Leu Ser Phe 
            420                 425                 430         


Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Leu Pro His Ala Gly Pro 
        435                 440                 445             


Ile Ile Val His Cys Ser Ala Gly Ile Gly Arg Thr Gly Thr Ile Ile 
    450                 455                 460                 


Val Ile Asp Met Leu Met Glu Asn Ile Ser Thr Lys Gly Leu Asp Cys 
465                 470                 475                 480 


Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Val Arg Ala Gln Arg Ser 
                485                 490                 495     


Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Phe Ile Tyr Val Ala Ile 
            500                 505                 510         


Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Leu Glu Val Leu Gln Ser 
        515                 520                 525             


Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Ile Thr Tyr Pro Pro Ala 
    530                 535                 540                 


Met Lys Asn Ala His Ala Lys Ala Ser Arg Thr Ser Ser Lys His Lys 
545                 550                 555                 560 


Glu Asp Val Tyr Glu Asn Leu His Thr Lys Asn Lys Arg Glu Glu Lys 
                565                 570                 575     


Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Lys Ser Lys Gly Ser Leu 
            580                 585                 590         


Lys Arg Lys 
        595 


<210>  5
<211>  597
<212>  PRT
<213>  homo sapiens

<400>  5

Met Thr Ser Arg Arg Trp Phe His Pro Asn Ile Thr Gly Val Glu Ala 
1               5                   10                  15      


Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gly Ser Phe Leu Ala Arg 
            20                  25                  30          


Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Leu Ser Val Arg Arg Asn 
        35                  40                  45              


Gly Ala Val Thr His Ile Lys Ile Gln Asn Thr Gly Asp Tyr Tyr Asp 
    50                  55                  60                  


Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Ala Glu Leu Val Gln Tyr 
65                  70                  75                  80  


Tyr Met Glu His His Gly Gln Leu Lys Glu Lys Asn Gly Asp Val Ile 
                85                  90                  95      


Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pro Thr Ser Glu Arg Trp 
            100                 105                 110         


Phe His Gly His Leu Ser Gly Lys Glu Ala Glu Lys Leu Leu Thr Glu 
        115                 120                 125             


Lys Gly Lys His Gly Ser Phe Leu Val Arg Glu Ser Gln Ser His Pro 
    130                 135                 140                 


Gly Asp Phe Val Leu Ser Val Arg Thr Gly Asp Asp Lys Gly Glu Ser 
145                 150                 155                 160 


Asn Asp Gly Lys Ser Lys Val Thr His Val Met Ile Arg Cys Gln Glu 
                165                 170                 175     


Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Phe Asp Ser Leu Thr Asp 
            180                 185                 190         


Leu Val Glu His Tyr Lys Lys Asn Pro Met Val Glu Thr Leu Gly Thr 
        195                 200                 205             


Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Thr Arg Ile Asn Ala Ala 
    210                 215                 220                 


Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Lys Leu Ala Glu Thr Thr 
225                 230                 235                 240 


Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Phe Glu Thr Leu Gln Gln 
                245                 250                 255     


Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Glu Gly Gln Arg Gln Glu 
            260                 265                 270         


Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe Asp His Thr 
        275                 280                 285             


Arg Val Val Leu His Asp Gly Asp Pro Asn Glu Pro Val Ser Asp Tyr 
    290                 295                 300                 


Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Glu Thr Lys Cys Asn Asn 
305                 310                 315                 320 


Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gln Gly Cys Leu Gln Asn 
                325                 330                 335     


Thr Val Asn Asp Phe Trp Arg Met Val Phe Gln Glu Asn Ser Arg Val 
            340                 345                 350         


Ile Val Met Thr Thr Lys Glu Val Glu Arg Gly Lys Ser Lys Cys Val 
        355                 360                 365             


Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Glu Tyr Gly Val Met Arg 
    370                 375                 380                 


Val Arg Asn Val Lys Glu Ser Ala Ala His Asp Tyr Thr Leu Arg Glu 
385                 390                 395                 400 


Leu Lys Leu Ser Lys Val Gly Gln Ala Leu Leu Gln Gly Asn Thr Glu 
                405                 410                 415     


Arg Thr Val Trp Gln Tyr His Phe Arg Thr Trp Pro Asp His Gly Val 
            420                 425                 430         


Pro Ser Asp Pro Gly Gly Val Leu Asp Phe Leu Glu Glu Val His His 
        435                 440                 445             


Lys Gln Glu Ser Ile Met Asp Ala Gly Pro Val Val Val His Cys Ser 
    450                 455                 460                 


Ala Gly Ile Gly Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Leu Ile 
465                 470                 475                 480 


Asp Ile Ile Arg Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pro Lys 
                485                 490                 495     


Thr Ile Gln Met Val Arg Ser Gln Arg Ser Gly Met Val Gln Thr Glu 
            500                 505                 510         


Ala Gln Tyr Arg Phe Ile Tyr Met Ala Val Gln His Tyr Ile Glu Thr 
        515                 520                 525             


Leu Gln Arg Arg Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gly His 
    530                 535                 540                 


Glu Tyr Thr Asn Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gly Asp 
545                 550                 555                 560 


Gln Ser Pro Leu Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Glu Met 
                565                 570                 575     


Arg Glu Asp Ser Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gln Gln 
            580                 585                 590         


Gln Lys Ser Phe Arg 
        595         


<210>  6
<211>  321
<212>  PRT
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence:PTP1B WPD-Loop Flip"

<400>  6

Met Glu Met Glu Lys Glu Phe Glu Gln Ile Asp Lys Ser Gly Ser Trp 
1               5                   10                  15      


Ala Ala Ile Tyr Gln Asp Ile Arg His Glu Ala Ser Asp Phe Pro Ser 
            20                  25                  30          


Arg Val Ala Lys Leu Pro Lys Asn Lys Asn Arg Asn Arg Tyr Arg Asp 
        35                  40                  45              


Val Ser Pro Phe Asp His Ser Arg Ile Lys Leu His Gln Glu Asp Asn 
    50                  55                  60                  


Asp Tyr Ile Asn Ala Ser Leu Ile Lys Met Glu Glu Ala Gln Arg Ser 
65                  70                  75                  80  


Tyr Ile Leu Thr Gln Gly Pro Leu Pro Asn Thr Ser Gly His Phe Trp 
                85                  90                  95      


Glu Met Val Trp Glu Gln Lys Ser Arg Gly Val Val Met Leu Asn Arg 
            100                 105                 110         


Val Met Glu Lys Gly Ser Leu Lys Ser Ala Gln Tyr Trp Pro Gln Lys 
        115                 120                 125             


Glu Glu Lys Glu Met Ile Phe Glu Asp Thr Asn Leu Lys Leu Thr Leu 
    130                 135                 140                 


Ile Ser Glu Asp Ile Lys Ser Tyr Tyr Thr Val Arg Gln Leu Glu Leu 
145                 150                 155                 160 


Glu Asn Leu Thr Thr Gln Glu Thr Arg Glu Ile Leu His Phe His Tyr 
                165                 170                 175     


Thr Thr Trp Pro Asp Cys Gly Val Pro Glu Ser Pro Ala Ser Phe Leu 
            180                 185                 190         


Asn Phe Leu Phe Lys Val Arg Glu Ser Gly Ser Leu Ser Pro Glu His 
        195                 200                 205             


Gly Pro Val Val Val His Ser Ser Ala Gly Ile Gly Arg Ser Gly Thr 
    210                 215                 220                 


Phe Cys Leu Ala Asp Thr Cys Leu Leu Leu Met Asp Lys Arg Lys Asp 
225                 230                 235                 240 


Pro Ser Ser Val Asp Ile Lys Lys Val Leu Leu Glu Met Arg Lys Phe 
                245                 250                 255     


Arg Met Gly Leu Ile Gln Thr Ala Asp Gln Leu Arg Phe Ser Tyr Leu 
            260                 265                 270         


Ala Val Ile Glu Gly Ala Lys Phe Ile Met Gly Asp Ser Ser Val Gln 
        275                 280                 285             


Asp Gln Trp Lys Glu Leu Ser His Glu Asp Leu Glu Pro Pro Pro Glu 
    290                 295                 300                 


His Ile Pro Pro Pro Pro Arg Pro Pro Lys Arg Ile Leu Glu Pro His 
305                 310                 315                 320 


Asn 
    


<210>  7
<211>  321
<212>  PRT
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence:PTP1B helix alpha7 
       Flip"

<400>  7

Met Glu Met Glu Lys Glu Phe Glu Gln Ile Asp Lys Ser Gly Ser Trp 
1               5                   10                  15      


Ala Ala Ile Tyr Gln Asp Ile Arg His Glu Ala Ser Asp Phe Pro Ser 
            20                  25                  30          


Arg Val Ala Lys Leu Pro Lys Asn Lys Asn Arg Asn Arg Tyr Arg Asp 
        35                  40                  45              


Val Ser Pro Phe Asp His Ser Arg Ile Lys Leu His Gln Glu Asp Asn 
    50                  55                  60                  


Asp Tyr Ile Asn Ala Ser Leu Ile Lys Met Glu Glu Ala Gln Arg Ser 
65                  70                  75                  80  


Tyr Ile Leu Thr Gln Gly Pro Leu Pro Asn Thr Ser Gly His Phe Trp 
                85                  90                  95      


Glu Met Val Trp Glu Gln Lys Ser Arg Gly Val Val Met Leu Asn Arg 
            100                 105                 110         


Val Met Glu Lys Gly Ser Leu Lys Ser Ala Gln Tyr Trp Pro Gln Lys 
        115                 120                 125             


Glu Glu Lys Glu Met Ile Phe Glu Asp Thr Asn Leu Lys Leu Thr Leu 
    130                 135                 140                 


Ile Ser Glu Asp Ile Lys Ser Tyr Tyr Thr Val Arg Gln Leu Glu Leu 
145                 150                 155                 160 


Glu Asn Leu Thr Thr Gln Glu Thr Arg Glu Ile Leu His Phe His Tyr 
                165                 170                 175     


Thr Thr Trp Pro Asp Phe Gly Val Pro Glu Ser Pro Ala Ser Phe Leu 
            180                 185                 190         


Asn Phe Leu Phe Lys Val Arg Glu Ser Gly Ser Leu Ser Pro Glu His 
        195                 200                 205             


Gly Pro Val Val Val His Ser Ser Ala Gly Ile Gly Arg Ser Gly Thr 
    210                 215                 220                 


Phe Cys Leu Ala Asp Thr Cys Leu Leu Leu Met Asp Lys Arg Lys Asp 
225                 230                 235                 240 


Pro Ser Ser Val Asp Ile Lys Lys Val Leu Leu Glu Met Arg Lys Phe 
                245                 250                 255     


Arg Met Gly Leu Ile Gln Thr Ala Asp Gln Leu Arg Phe Ser Tyr Leu 
            260                 265                 270         


Ala Val Ile Glu Gly Ala Lys Phe Ile Met Gly Asp Ser Ser Val Gln 
        275                 280                 285             


Asp Gln Trp Lys Glu Cys Ser His Glu Asp Leu Glu Pro Pro Pro Glu 
    290                 295                 300                 


His Ile Pro Pro Pro Pro Arg Pro Pro Lys Arg Ile Leu Glu Pro His 
305                 310                 315                 320 


Asn 
    


<210>  8
<211>  321
<212>  PRT
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence:truncated PTP1B wild 
       type"

<400>  8

Met Glu Met Glu Lys Glu Phe Glu Gln Ile Asp Lys Ser Gly Ser Trp 
1               5                   10                  15      


Ala Ala Ile Tyr Gln Asp Ile Arg His Glu Ala Ser Asp Phe Pro Cys 
            20                  25                  30          


Arg Val Ala Lys Leu Pro Lys Asn Lys Asn Arg Asn Arg Tyr Arg Asp 
        35                  40                  45              


Val Ser Pro Phe Asp His Ser Arg Ile Lys Leu His Gln Glu Asp Asn 
    50                  55                  60                  


Asp Tyr Ile Asn Ala Ser Leu Ile Lys Met Glu Glu Ala Gln Arg Ser 
65                  70                  75                  80  


Tyr Ile Leu Thr Gln Gly Pro Leu Pro Asn Thr Cys Gly His Phe Trp 
                85                  90                  95      


Glu Met Val Trp Glu Gln Lys Ser Arg Gly Val Val Met Leu Asn Arg 
            100                 105                 110         


Val Met Glu Lys Gly Ser Leu Lys Cys Ala Gln Tyr Trp Pro Gln Lys 
        115                 120                 125             


Glu Glu Lys Glu Met Ile Phe Glu Asp Thr Asn Leu Lys Leu Thr Leu 
    130                 135                 140                 


Ile Ser Glu Asp Ile Lys Ser Tyr Tyr Thr Val Arg Gln Leu Glu Leu 
145                 150                 155                 160 


Glu Asn Leu Thr Thr Gln Glu Thr Arg Glu Ile Leu His Phe His Tyr 
                165                 170                 175     


Thr Thr Trp Pro Asp Phe Gly Val Pro Glu Ser Pro Ala Ser Phe Leu 
            180                 185                 190         


Asn Phe Leu Phe Lys Val Arg Glu Ser Gly Ser Leu Ser Pro Glu His 
        195                 200                 205             


Gly Pro Val Val Val His Cys Ser Ala Gly Ile Gly Arg Ser Gly Thr 
    210                 215                 220                 


Phe Cys Leu Ala Asp Thr Cys Leu Leu Leu Met Asp Lys Arg Lys Asp 
225                 230                 235                 240 


Pro Ser Ser Val Asp Ile Lys Lys Val Leu Leu Glu Met Arg Lys Phe 
                245                 250                 255     


Arg Met Gly Leu Ile Gln Thr Ala Asp Gln Leu Arg Phe Ser Tyr Leu 
            260                 265                 270         


Ala Val Ile Glu Gly Ala Lys Phe Ile Met Gly Asp Ser Ser Val Gln 
        275                 280                 285             


Asp Gln Trp Lys Glu Leu Ser His Glu Asp Leu Glu Pro Pro Pro Glu 
    290                 295                 300                 


His Ile Pro Pro Pro Pro Arg Pro Pro Lys Arg Ile Leu Glu Pro His 
305                 310                 315                 320 


Asn 
    


