     
     Sequence list

     Seq. Id. No. 1 protein sequence of human complement factor H.
 
       1  MRLLAKIICL MLWAICVAED CNELPPRRNT EILTGSWSDQ TYPEGTQAIY

      51  KCRPGYRSLG NVIMVCRKGE WVALNPLRKC QKRPCGHPGD TPFGTFTLTG

     101  GNVFEYGVKA VYTCNEGYQL LGEINYRECD TDGWTNDIPI CEVVKCLPVT

     151  APENGKIVSS AMEPDREYHF GQAVRFVCNS GYKIEGDEEM HCSDDGFWSK

     201  EKPKCVEISC KSPDVINGSP ISQKIIYKEN ERFQYKCNMG YEYSERGDAV

     251  CTESGWRPLP SCEEKSCDNP YIPNGDYSPL RIKHRTGDEI TYQCRNGFYP

     301  ATRGNTAKCT STGWIPAPRC TLKPCDYPDI KHGGLYHENM RRPYFPVAVG

     351  KYYSYYCDEH FETPSGSYWD HIHCTQDGWS PAVPCLRKCY FPYLENGYNQ

     401  NYGRKFVQGK SIDVACHPGY ALPKAQTTVT CMENGWSPTP RCIRVKTCSK

     451  SSIDIENGFI SESQYTYALK EKAKYQCKLG YVTADGETSG SITCGKDGWS

     501  AQPTCIKSCD IPVFMNARTK NDFTWFKLND TLDYECHDGY ESNTGSTTGS

     551  IVCGYNGWSD LPICYERECE LPKIDVHLVP DRKKDQYKVG EVLKFSCKPG

     601  FTIVGPNSVQ CYHFGLSPDL PICKEQVQSC GPPPELLNGN VKEKTKEEYG

     651  HSEVVEYYCN PRFLMKGPNK IQCVDGEWTT LPVCIVEEST CGDIPELEHG

     701  WAQLSSPPYY YGDSVEFNCS ESFTMIGHRS ITCIHGVWTQ LPQCVAIDKL

     751  KKCKSSNLII LEEHLKNKKE FDHNSNIRYR CRGKEGWIHT VCINGRWDPE

     801  VNCSMAQIQL CPPPPQIPNS HNMTTTLNYR DGEKVSVLCQ ENYLIQEGEE

     851  ITCKDGRWQS IPLCVEKIPC SQPPQIEHGT INSSRSSQES YAHGTKLSYT

     901  CEGGFRISEE NETTCYMGKW SSPPQCEGLP CKSPPEISHG VVAHMSDSYQ

     951  YGEEVTYKCF EGFGIDGPAI AKCLGEKWSH PPSCIKTDCL SLPSFENAIP

    1001  MGEKKDVYKA GEQVTYTCAT YYKMDGASNV TCINSRWTGR PTCRDTSCVN

    1051  PPTVQNAYIV SRQMSKYPSG ERVRYQCRSP YEMFGDEEVM CLNGNWTEPP

    1101  QCKDSTGKCG PPPPIDNGDI TSFPLSVYAP ASSVEYQCQN LYQLEGNKRI

    1151  TCRNGQWSEP PKCLHPCVIS REIMENYNIA LRWTAKQKLY SRTGESVEFV

    1201  CKRGYRLSSR SHTLRTTCWD GKLEYPTCAK R

     with variants

	VAR SEQ 446-449       	KTCS -> SFTL (in isoform 2).

	VAR SEQ 450-1231	Missing (in isoform 2).

	VARIANT 62           	V -> I

	VARIANT 78            	R -> G

	VARIANT 127           	R -> L

	VARIANT 224           	missing

	VARIANT 325           	C -> Y

	VARIANT 400           	Q -> K

	VARIANT 402           	Y -> H

	VARIANT 431           	C -> S

	VARIANT 493           	T -> R

	VARIANT 536           	C -> R

	VARIANT 551           	I -> T

	VARIANT 567           	R -> G

	VARIANT 609           	V -> I

	VARIANT 630           	C -> W

	VARIANT 673           	C -> S

	VARIANT 673           	C -> Y

	VARIANT 850           	E -> K

	VARIANT 890           	S -> I

	VARIANT 893           	H -> R

	VARIANT 915           	C -> S

	VARIANT 936           	E -> D

	VARIANT 950           	Q -> H

	VARIANT 951           	Y -> H

	VARIANT 956           	T -> M

	VARIANT 959           	C -> Y

	VARIANT 978           	W -> C

	VARIANT 997           	N -> T

	VARIANT 1007            V -> I
	
	VARIANT 1007            V -> L
	
	VARIANT 1010            A -> T
	
	VARIANT 1017            T -> I
	
	VARIANT 1021            Y -> F
	
	VARIANT 1043            C -> R
	
	VARIANT 1050            N -> Y
	
	VARIANT 1059            I -> T
	
	VARIANT 1076            Q -> E
	
	VARIANT 1078          	R -> S

	VARIANT 1119          	D -> G

	VARIANT 1134          	V -> G

	VARIANT 1142          	Y -> D

	VARIANT 1143          	Q -> E

	VARIANT 1157          	W -> R

	VARIANT 1163            C -> W

	VARIANT 1169          	I -> L

	VARIANT 1183          	W -> C

	VARIANT 1183          	W -> L

	VARIANT 1183          	W -> R

	VARIANT 1184          	T -> R

	VARIANT 1189          	L -> R

	VARIANT 1191          	S -> L

	VARIANT 1194          	G -> D

	VARIANT 1197          	V -> A

	VARIANT 1198          	E -> A

	VARIANT 1199            F -> S

	VARIANT 1210          	R -> C

	VARIANT 1215            R -> G

	VARIANT 1215          	R -> Q

	VARIANT 1225-1231      YPTCAKR -> FQS  

	VARIANT 1226          	P -> S
	


     Seq. Id. No. 2 protein sequence of human complement factor H related protein CFHR1.
 
       1  MWLLVSVILI SRISSVGGEA TFCDFPKINH GILYDEEKYK PFSQVPTGEV

      51  FYYSCEYNFV SPSKSFWTRI TCTEEGWSPT PKCLRLCFFP FVENGHSESS

     101  GQTHLEGDTV QIICNTGYRL QNNENNISCV ERGWSTPPKC RSTDTSCVNP

     151  PTVQNAHILS RQMSKYPSGE RVRYECRSPY EMFGDEEVMC LNGNWTEPPQ

     201  CKDSTGKCGP PPPIDNGDIT SFPLSVYAPA SSVEYQCQNL YQLEGNKRIT

     251  CRNGQWSEPP KCLHPCVISR EIMENYNIAL RWTAKQKLYL RTGESAEFVC

     301  KRGYRLSSRS HTLRTTCWDG KLEYPTCAKR

     with variants

	VARIANT 157           	H -> Y

	VARIANT 159             L -> V

	VARIANT 175           	E -> Q

	VARIANT 296           	A -> V

     Seq. Id. No. 3 protein sequence of human complement factor H related protein CFHR2.
 
	1  MWLLVSVILI SRISSVGGEA MFCDFPKINH GILYDEEKYK PFSQVPTGEV

      51  FYYSCEYNFV SPSKSFWTRI TCAEEGWSPT PKCLRLCFFP FVENGHSESS

     101  GQTHLEGDTV QIICNTGYRL QNNENNISCV ERGWSTPPKC RSTISAEKCG

     151  PPPPIDNGDI TSFLLSVYAP GSSVEYQCQN LYQLEGNNQI TCRNGQWSEP

     201  PKCLDPCVIS QEIMEKYNIK LKWTNQQKLY SRTGDIVEFV CKSGYHPTKS

     251  HSFRAMCQNG KLVYPSCEEK

     with variant

	ISOFORM   144-171       ISAEKCGPPPPIDNGDITSFLLSVYAPG -> S
 
                        	 (in isoform Short).


     Seq. Id. No. 4 protein sequence of human complement factor H related protein CFHR3.
 
       1  MLLLINVILT LWVSCANGQV KPCDFPDIKH GGLFHENMRR PYFPVAVGKY

      51  YSYYCDEHFE TPSGSYWDYI HCTQNGWSPA VPCLRKCYFP YLENGYNQNY

     101  GRKFVQGNST EVACHPGYGL PKAQTTVTCT EKGWSPTPRC IRVRTCSKSD
	
     151  IEIENGFISE SSSIYILNKE IQYKCKPGYA TADGNSSGSI TCLQNGWSAQ

     201  PICINSSEKC GPPPPISNGD TTSFLLKVYV PQSRVEYQCQ PYYELQGSNY

     251  VTCSNGEWSE PPRCIHPCII TEENMNKNNI KLKGRSDRKY YAKTGDTIEF

     301  MCKLGYNANT SILSFQAVCR EGIVEYPRCE
     
     with variant

	VARIANT 71           	H -> Y


     Seq. Id. No. 5 protein sequence of human complement factor H related protein CFHR4A. 

       1  MLLLINVILT LWVSCANGQE VKPCDFPEIQ HGGLYYKSLR RLYFPAAAGQ

      51  SYSYYCDQNF VTPSGSYWDY IHCTQDGWSP TVPCLRTCSK SDVEIENGFI

     101  SESSSIYILN EETQYNCKPG YATADGNSSG SITCLQNGWS TQPICIKFCD

     151  MPVFENSRAK SNGMWFKLHD TLDYECYDGY ESSYGNTTDS IVCGEDGWSH

     201  LPTCYNSSEN CGPPPPISNG DTTSFPQKVY LPWSRVEYQC QSYYELQGSK

     251  YVTCSNGDWS EPPRCISMKP CEFPEIQHGH LYYENTRRPY FPVATGQSYS

     301  YYCDQNFVTP SGSYWDYIHC TQDGWLPTVP CLRTCSKSDI EIENGFISES

     351  SSIYILNKEI QYKCKPGYAT ADGNSSGSIT CLQNGWSAQP ICIKFCDMPV

     401  FENSRAKSNG MRFKLHDTLD YECYDGYEIS YGNTTGSIVC GEDGWSHFPT

     451  CYNSSEKCGP PPPISNGDTT SFLLKVYVPQ SRVEYQCQSY YELQGSNYVT

     501  CSNGEWSEPP RCIHPCIITE ENMNKNNIQL KGKSDIKYYA KTGDTIEFMC

     551  KLGYNANTSV LSFQAVCREG IVEYPRCE

     
     Seq. Id. No. 6 protein sequence of human complement factor H related protein CFHR4B. 

       1  MLLLINVILT LWVSCANGQE VKPCDFPEIQ HGGLYYKSLR RLYFPAAAGQ

      51  SYSYYCDQNF VTPSGSYWDY IHCTQDGWSP TVPCLRTCSK SDIEIENGFI

     101  SESSSIYILN KEIQYKCKPG YATADGNSSG SITCLQNGWS AQPICIKFCD

     151  MPVFENSRAK SNGMRFKLHD TLDYECYDGY EISYGNTTGS IVCGEDGWSH

     201  FPTCYNSSEK CGPPPPISNG DTTSFLLKVY VPQSRVEYQC QSYYELQGSN

     251  YVTCSNGEWS EPPRCIHPCI ITEENMNKNN IQLKGKSDIK YYAKTGDTIE

     301  FMCKLGYNAN TSVLSFQAVC REGIVEYPRC E

     with variant

	VARIANT 306           	G -> E


     Seq. Id. No. 7 protein sequence of human complement factor H related protein CFHR5. 

       1  MLLLFSVILI SWVSTVGGEG TLCDFPKIHH GFLYDEEDYN PFSQVPTGEV

      51  FYYSCEYNFV SPSKSFWTRI TCTEEGWSPT PKCLRMCSFP FVKNGHSESS

     101  GLIHLEGDTV QIICNTGYSL QNNEKNISCV ERGWSTPPIC SFTKGECHVP

     151  ILEANVDAQP KKESYKVGDV LKFSCRKNLI RVGSDSVQCY QFGWSPNFPT

     201  CKGQVRSCGP PPQLSNGEVK EIRKEEYGHN EVVEYDCNPN FIINGPKKIQ

     251  CVDGEWTTLP TCVEQVKTCG YIPELEYGYV QPSVPPYQHG VSVEVNCRNE

     301  YAMIGNNMIT CINGIWTELP MCVATHQLKR CKIAGVNIKT LLKLSGKEFN

     351  HNSRIRYRCS DIFRYRHSVC INGKWNPEVD CTEKREQFCP PPPQIPNAQN

     401  MTTTVNYQDG EKVAVLCKEN YLLPEAKEIV CKDGRWQSLP RCVESTAYCG

     451  PPPSINNGDT TSFPLSVYPP GSTVTYRCQS FYKLQGSVTV TCRNKQWSEP

     501  PRCLDPCVVS EENMNKNNIQ LKWRNDGKLY AKTGDAVEFQ CKFPHKAMIS

     551  SPPFRAICQE GKFEYPICE

     with variants

	VARIANT  46            P -> S 

	VARIANT 216            N -> S 

	VARIANT 277            Y -> N 

	VARIANT 356            R -> H
 
	VARIANT 379            V -> L 

	VARIANT 521            L -> I 

	VARIANT 529            L -> R


      Seq. Id. No. 8 oligonucleotide sequence for the forward primer used in the customized CFHR1 copy number assay
	
	CAG TTC CAA TTG TGT CCA AGT GGA TGT

      Seq. Id. No. 9 oligonucleotide sequence for the reverse primer used in the customized CFHR1 copy number assay
	
	CAT TTC AAA CAA TCT CCA AGG AGA TGA TG

      Seq. Id. No. 10 oligonucleotide sequence for the probe used in the customized CFHR1 copy number assay

	CAA ATG TTC TCA AAG TGT GGT CGC T

