                               SEQUENCE LISTING

<110> FOUNDATION MEDICINE, INC.
 
<120> NOVEL KIF5B-RET FUSION MOLECULES AND USES THEREOF

<130> F2036-7025WO

<140> PCT/US2012/051978
<141> 2012-08-23

<150> 61/594,739
<151> 2012-02-03

<150> 61/542,112
<151> 2011-09-30

<150> 61/537,024
<151> 2011-09-20

<150> 61/526,613
<151> 2011-08-23

<160> 9     

<170> PatentIn version 3.5

<210> 1
<211> 2934
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (1)..(2931)

<400> 1
atg gcg gac ctg gcc gag tgc aac atc aaa gtg atg tgt cgc ttc aga         48
Met Ala Asp Leu Ala Glu Cys Asn Ile Lys Val Met Cys Arg Phe Arg           
1               5                   10                  15                

cct ctc aac gag tct gaa gtg aac cgc ggc gac aag tac atc gcc aag         96
Pro Leu Asn Glu Ser Glu Val Asn Arg Gly Asp Lys Tyr Ile Ala Lys           
            20                  25                  30                    

ttt cag gga gaa gac acg gtc gtg atc gcg tcc aag cct tat gca ttt        144
Phe Gln Gly Glu Asp Thr Val Val Ile Ala Ser Lys Pro Tyr Ala Phe           
        35                  40                  45                        

gat cgg gtg ttc cag tca agc aca tct caa gag caa gtg tat aat gac        192
Asp Arg Val Phe Gln Ser Ser Thr Ser Gln Glu Gln Val Tyr Asn Asp           
    50                  55                  60                            

tgt gca aag aag att gtt aaa gat gta ctt gaa gga tat aat gga aca        240
Cys Ala Lys Lys Ile Val Lys Asp Val Leu Glu Gly Tyr Asn Gly Thr           
65                  70                  75                  80            

ata ttt gca tat gga caa aca tcc tct ggg aag aca cac aca atg gag        288
Ile Phe Ala Tyr Gly Gln Thr Ser Ser Gly Lys Thr His Thr Met Glu           
                85                  90                  95                

ggt aaa ctt cat gat cca gaa ggc atg gga att att cca aga ata gtg        336
Gly Lys Leu His Asp Pro Glu Gly Met Gly Ile Ile Pro Arg Ile Val           
            100                 105                 110                   

caa gat att ttt aat tat att tac tcc atg gat gaa aat ttg gaa ttt        384
Gln Asp Ile Phe Asn Tyr Ile Tyr Ser Met Asp Glu Asn Leu Glu Phe           
        115                 120                 125                       

cat att aag gtt tca tat ttt gaa ata tat ttg gat aag ata agg gac        432
His Ile Lys Val Ser Tyr Phe Glu Ile Tyr Leu Asp Lys Ile Arg Asp           
    130                 135                 140                           

ctg tta gat gtt tca aag acc aac ctt tca gtt cat gaa gac aaa aac        480
Leu Leu Asp Val Ser Lys Thr Asn Leu Ser Val His Glu Asp Lys Asn           
145                 150                 155                 160           

cga gtt ccc tat gta aag ggg tgc aca gag cgt ttt gta tgt agt cca        528
Arg Val Pro Tyr Val Lys Gly Cys Thr Glu Arg Phe Val Cys Ser Pro           
                165                 170                 175               

gat gaa gtt atg gat acc ata gat gaa gga aaa tcc aac aga cat gta        576
Asp Glu Val Met Asp Thr Ile Asp Glu Gly Lys Ser Asn Arg His Val           
            180                 185                 190                   

gca gtt aca aat atg aat gaa cat agc tct agg agt cac agt ata ttt        624
Ala Val Thr Asn Met Asn Glu His Ser Ser Arg Ser His Ser Ile Phe           
        195                 200                 205                       

ctt att aat gtc aaa caa gag aac aca caa acg gaa caa aag ctg agt        672
Leu Ile Asn Val Lys Gln Glu Asn Thr Gln Thr Glu Gln Lys Leu Ser           
    210                 215                 220                           

gga aaa ctt tat ctg gtt gat tta gct ggt agt gaa aag gtt agt aaa        720
Gly Lys Leu Tyr Leu Val Asp Leu Ala Gly Ser Glu Lys Val Ser Lys           
225                 230                 235                 240           

act gga gct gaa ggt gct gtg ctg gat gaa gct aaa aac atc aac aag        768
Thr Gly Ala Glu Gly Ala Val Leu Asp Glu Ala Lys Asn Ile Asn Lys           
                245                 250                 255               

tca ctt tct gct ctt gga aat gtt att tct gct ttg gct gag ggt agt        816
Ser Leu Ser Ala Leu Gly Asn Val Ile Ser Ala Leu Ala Glu Gly Ser           
            260                 265                 270                   

aca tat gtt cca tat cga gat agt aaa atg aca aga atc ctt caa gat        864
Thr Tyr Val Pro Tyr Arg Asp Ser Lys Met Thr Arg Ile Leu Gln Asp           
        275                 280                 285                       

tca tta ggt ggc aac tgt aga acc act att gta att tgc tgc tct cca        912
Ser Leu Gly Gly Asn Cys Arg Thr Thr Ile Val Ile Cys Cys Ser Pro           
    290                 295                 300                           

tca tca tac aat gag tct gaa aca aaa tct aca ctc tta ttt ggc caa        960
Ser Ser Tyr Asn Glu Ser Glu Thr Lys Ser Thr Leu Leu Phe Gly Gln           
305                 310                 315                 320           

agg gcc aaa aca att aag aac aca gtt tgt gtc aat gtg gag tta act       1008
Arg Ala Lys Thr Ile Lys Asn Thr Val Cys Val Asn Val Glu Leu Thr           
                325                 330                 335               

gca gaa cag tgg aaa aag aag tat gaa aaa gaa aaa gaa aaa aat aag       1056
Ala Glu Gln Trp Lys Lys Lys Tyr Glu Lys Glu Lys Glu Lys Asn Lys           
            340                 345                 350                   

atc ctg cgg aac act att cag tgg ctt gaa aat gag ctc aac aga tgg       1104
Ile Leu Arg Asn Thr Ile Gln Trp Leu Glu Asn Glu Leu Asn Arg Trp           
        355                 360                 365                       

cgt aat ggg gag acg gtg cct att gat gaa cag ttt gac aaa gag aaa       1152
Arg Asn Gly Glu Thr Val Pro Ile Asp Glu Gln Phe Asp Lys Glu Lys           
    370                 375                 380                           

gcc aac ttg gaa gct ttc aca gtg gat aaa gat att act ctt acc aat       1200
Ala Asn Leu Glu Ala Phe Thr Val Asp Lys Asp Ile Thr Leu Thr Asn           
385                 390                 395                 400           

gat aaa cca gca acc gca att gga gtt ata gga aat ttt act gat gct       1248
Asp Lys Pro Ala Thr Ala Ile Gly Val Ile Gly Asn Phe Thr Asp Ala           
                405                 410                 415               

gaa aga aga aag tgt gaa gaa gaa att gct aaa tta tac aaa cag ctt       1296
Glu Arg Arg Lys Cys Glu Glu Glu Ile Ala Lys Leu Tyr Lys Gln Leu           
            420                 425                 430                   

gat gac aag gat gaa gaa att aac cag caa agt caa ctg gta gag aaa       1344
Asp Asp Lys Asp Glu Glu Ile Asn Gln Gln Ser Gln Leu Val Glu Lys           
        435                 440                 445                       

ctg aag acg caa atg ttg gat cag gag gag ctt ttg gca tct acc aga       1392
Leu Lys Thr Gln Met Leu Asp Gln Glu Glu Leu Leu Ala Ser Thr Arg           
    450                 455                 460                           

agg gat caa gac aat atg caa gct gag ctg aat cgc ctt caa gca gaa       1440
Arg Asp Gln Asp Asn Met Gln Ala Glu Leu Asn Arg Leu Gln Ala Glu           
465                 470                 475                 480           

aat gat gcc tct aaa gaa gaa gtg aaa gaa gtt tta cag gcc cta gaa       1488
Asn Asp Ala Ser Lys Glu Glu Val Lys Glu Val Leu Gln Ala Leu Glu           
                485                 490                 495               

gaa ctt gct gtc aat tat gat cag aag tct cag gaa gtt gaa gac aaa       1536
Glu Leu Ala Val Asn Tyr Asp Gln Lys Ser Gln Glu Val Glu Asp Lys           
            500                 505                 510                   

act aag gaa tat gaa ttg ctt agt gat gaa ttg aat cag aaa tcg gca       1584
Thr Lys Glu Tyr Glu Leu Leu Ser Asp Glu Leu Asn Gln Lys Ser Ala           
        515                 520                 525                       

act tta gcg agt ata gat gct gag ctt cag aaa ctt aag gaa atg acc       1632
Thr Leu Ala Ser Ile Asp Ala Glu Leu Gln Lys Leu Lys Glu Met Thr           
    530                 535                 540                           

aac cac cag aaa aaa cga gca gct gag atg atg gca tct tta cta aaa       1680
Asn His Gln Lys Lys Arg Ala Ala Glu Met Met Ala Ser Leu Leu Lys           
545                 550                 555                 560           

gac ctt gca gaa ata gga att gct gtg gga aat aat gat gta aag gag       1728
Asp Leu Ala Glu Ile Gly Ile Ala Val Gly Asn Asn Asp Val Lys Glu           
                565                 570                 575               

gat cca aag tgg gaa ttc cct cgg aag aac ttg gtt ctt gga aaa act       1776
Asp Pro Lys Trp Glu Phe Pro Arg Lys Asn Leu Val Leu Gly Lys Thr           
            580                 585                 590                   

cta gga gaa ggc gaa ttt gga aaa gtg gtc aag gca acg gcc ttc cat       1824
Leu Gly Glu Gly Glu Phe Gly Lys Val Val Lys Ala Thr Ala Phe His           
        595                 600                 605                       

ctg aaa ggc aga gca ggg tac acc acg gtg gcc gtg aag atg ctg aaa       1872
Leu Lys Gly Arg Ala Gly Tyr Thr Thr Val Ala Val Lys Met Leu Lys           
    610                 615                 620                           

gag aac gcc tcc ccg agt gag ctg cga gac ctg ctg tca gag ttc aac       1920
Glu Asn Ala Ser Pro Ser Glu Leu Arg Asp Leu Leu Ser Glu Phe Asn           
625                 630                 635                 640           

gtc ctg aag cag gtc aac cac cca cat gtc atc aaa ttg tat ggg gcc       1968
Val Leu Lys Gln Val Asn His Pro His Val Ile Lys Leu Tyr Gly Ala           
                645                 650                 655               

tgc agc cag gat ggc ccg ctc ctc ctc atc gtg gag tac gcc aaa tac       2016
Cys Ser Gln Asp Gly Pro Leu Leu Leu Ile Val Glu Tyr Ala Lys Tyr           
            660                 665                 670                   

ggc tcc ctg cgg ggc ttc ctc cgc gag agc cgc aaa gtg ggg cct ggc       2064
Gly Ser Leu Arg Gly Phe Leu Arg Glu Ser Arg Lys Val Gly Pro Gly           
        675                 680                 685                       

tac ctg ggc agt gga ggc agc cgc aac tcc agc tcc ctg gac cac ccg       2112
Tyr Leu Gly Ser Gly Gly Ser Arg Asn Ser Ser Ser Leu Asp His Pro           
    690                 695                 700                           

gat gag cgg gcc ctc acc atg ggc gac ctc atc tca ttt gcc tgg cag       2160
Asp Glu Arg Ala Leu Thr Met Gly Asp Leu Ile Ser Phe Ala Trp Gln           
705                 710                 715                 720           

atc tca cag ggg atg cag tat ctg gcc gag atg aag ctc gtt cat cgg       2208
Ile Ser Gln Gly Met Gln Tyr Leu Ala Glu Met Lys Leu Val His Arg           
                725                 730                 735               

gac ttg gca gcc aga aac atc ctg gta gct gag ggg cgg aag atg aag       2256
Asp Leu Ala Ala Arg Asn Ile Leu Val Ala Glu Gly Arg Lys Met Lys           
            740                 745                 750                   

att tcg gat ttc ggc ttg tcc cga gat gtt tat gaa gag gat tcc tac       2304
Ile Ser Asp Phe Gly Leu Ser Arg Asp Val Tyr Glu Glu Asp Ser Tyr           
        755                 760                 765                       

gtg aag agg agc cag ggt cgg att cca gtt aaa tgg atg gca att gaa       2352
Val Lys Arg Ser Gln Gly Arg Ile Pro Val Lys Trp Met Ala Ile Glu           
    770                 775                 780                           

tcc ctt ttt gat cat atc tac acc acg caa agt gat gta tgg tct ttt       2400
Ser Leu Phe Asp His Ile Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe           
785                 790                 795                 800           

ggt gtc ctg ctg tgg gag atc gtg acc cta ggg gga aac ccc tat cct       2448
Gly Val Leu Leu Trp Glu Ile Val Thr Leu Gly Gly Asn Pro Tyr Pro           
                805                 810                 815               

ggg att cct cct gag cgg ctc ttc aac ctt ctg aag acc ggc cac cgg       2496
Gly Ile Pro Pro Glu Arg Leu Phe Asn Leu Leu Lys Thr Gly His Arg           
            820                 825                 830                   

atg gag agg cca gac aac tgc agc gag gag atg tac cgc ctg atg ctg       2544
Met Glu Arg Pro Asp Asn Cys Ser Glu Glu Met Tyr Arg Leu Met Leu           
        835                 840                 845                       

caa tgc tgg aag cag gag ccg gac aaa agg ccg gtg ttt gcg gac atc       2592
Gln Cys Trp Lys Gln Glu Pro Asp Lys Arg Pro Val Phe Ala Asp Ile           
    850                 855                 860                           

agc aaa gac ctg gag aag atg atg gtt aag agg aga gac tac ttg gac       2640
Ser Lys Asp Leu Glu Lys Met Met Val Lys Arg Arg Asp Tyr Leu Asp           
865                 870                 875                 880           

ctt gcg gcg tcc act cca tct gac tcc ctg att tat gac gac ggc ctc       2688
Leu Ala Ala Ser Thr Pro Ser Asp Ser Leu Ile Tyr Asp Asp Gly Leu           
                885                 890                 895               

tca gag gag gag aca ccg ctg gtg gac tgt aat aat gcc ccc ctc cct       2736
Ser Glu Glu Glu Thr Pro Leu Val Asp Cys Asn Asn Ala Pro Leu Pro           
            900                 905                 910                   

cga gcc ctc cct tcc aca tgg att gaa aac aaa ctc tat ggc atg tca       2784
Arg Ala Leu Pro Ser Thr Trp Ile Glu Asn Lys Leu Tyr Gly Met Ser           
        915                 920                 925                       

gac ccg aac tgg cct gga gag agt cct gta cca ctc acg aga gct gat       2832
Asp Pro Asn Trp Pro Gly Glu Ser Pro Val Pro Leu Thr Arg Ala Asp           
    930                 935                 940                           

ggc act aac act ggg ttt cca aga tat cca aat gat agt gta tat gct       2880
Gly Thr Asn Thr Gly Phe Pro Arg Tyr Pro Asn Asp Ser Val Tyr Ala           
945                 950                 955                 960           

aac tgg atg ctt tca ccc tca gcg gca aaa tta atg gac acg ttt gat       2928
Asn Trp Met Leu Ser Pro Ser Ala Ala Lys Leu Met Asp Thr Phe Asp           
                965                 970                 975               

agt taa                                                               2934
Ser                                                                       
                                                                          


<210> 2
<211> 977
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Met Ala Asp Leu Ala Glu Cys Asn Ile Lys Val Met Cys Arg Phe Arg 
1               5                   10                  15      


Pro Leu Asn Glu Ser Glu Val Asn Arg Gly Asp Lys Tyr Ile Ala Lys 
            20                  25                  30          


Phe Gln Gly Glu Asp Thr Val Val Ile Ala Ser Lys Pro Tyr Ala Phe 
        35                  40                  45              


Asp Arg Val Phe Gln Ser Ser Thr Ser Gln Glu Gln Val Tyr Asn Asp 
    50                  55                  60                  


Cys Ala Lys Lys Ile Val Lys Asp Val Leu Glu Gly Tyr Asn Gly Thr 
65                  70                  75                  80  


Ile Phe Ala Tyr Gly Gln Thr Ser Ser Gly Lys Thr His Thr Met Glu 
                85                  90                  95      


Gly Lys Leu His Asp Pro Glu Gly Met Gly Ile Ile Pro Arg Ile Val 
            100                 105                 110         


Gln Asp Ile Phe Asn Tyr Ile Tyr Ser Met Asp Glu Asn Leu Glu Phe 
        115                 120                 125             


His Ile Lys Val Ser Tyr Phe Glu Ile Tyr Leu Asp Lys Ile Arg Asp 
    130                 135                 140                 


Leu Leu Asp Val Ser Lys Thr Asn Leu Ser Val His Glu Asp Lys Asn 
145                 150                 155                 160 


Arg Val Pro Tyr Val Lys Gly Cys Thr Glu Arg Phe Val Cys Ser Pro 
                165                 170                 175     


Asp Glu Val Met Asp Thr Ile Asp Glu Gly Lys Ser Asn Arg His Val 
            180                 185                 190         


Ala Val Thr Asn Met Asn Glu His Ser Ser Arg Ser His Ser Ile Phe 
        195                 200                 205             


Leu Ile Asn Val Lys Gln Glu Asn Thr Gln Thr Glu Gln Lys Leu Ser 
    210                 215                 220                 


Gly Lys Leu Tyr Leu Val Asp Leu Ala Gly Ser Glu Lys Val Ser Lys 
225                 230                 235                 240 


Thr Gly Ala Glu Gly Ala Val Leu Asp Glu Ala Lys Asn Ile Asn Lys 
                245                 250                 255     


Ser Leu Ser Ala Leu Gly Asn Val Ile Ser Ala Leu Ala Glu Gly Ser 
            260                 265                 270         


Thr Tyr Val Pro Tyr Arg Asp Ser Lys Met Thr Arg Ile Leu Gln Asp 
        275                 280                 285             


Ser Leu Gly Gly Asn Cys Arg Thr Thr Ile Val Ile Cys Cys Ser Pro 
    290                 295                 300                 


Ser Ser Tyr Asn Glu Ser Glu Thr Lys Ser Thr Leu Leu Phe Gly Gln 
305                 310                 315                 320 


Arg Ala Lys Thr Ile Lys Asn Thr Val Cys Val Asn Val Glu Leu Thr 
                325                 330                 335     


Ala Glu Gln Trp Lys Lys Lys Tyr Glu Lys Glu Lys Glu Lys Asn Lys 
            340                 345                 350         


Ile Leu Arg Asn Thr Ile Gln Trp Leu Glu Asn Glu Leu Asn Arg Trp 
        355                 360                 365             


Arg Asn Gly Glu Thr Val Pro Ile Asp Glu Gln Phe Asp Lys Glu Lys 
    370                 375                 380                 


Ala Asn Leu Glu Ala Phe Thr Val Asp Lys Asp Ile Thr Leu Thr Asn 
385                 390                 395                 400 


Asp Lys Pro Ala Thr Ala Ile Gly Val Ile Gly Asn Phe Thr Asp Ala 
                405                 410                 415     


Glu Arg Arg Lys Cys Glu Glu Glu Ile Ala Lys Leu Tyr Lys Gln Leu 
            420                 425                 430         


Asp Asp Lys Asp Glu Glu Ile Asn Gln Gln Ser Gln Leu Val Glu Lys 
        435                 440                 445             


Leu Lys Thr Gln Met Leu Asp Gln Glu Glu Leu Leu Ala Ser Thr Arg 
    450                 455                 460                 


Arg Asp Gln Asp Asn Met Gln Ala Glu Leu Asn Arg Leu Gln Ala Glu 
465                 470                 475                 480 


Asn Asp Ala Ser Lys Glu Glu Val Lys Glu Val Leu Gln Ala Leu Glu 
                485                 490                 495     


Glu Leu Ala Val Asn Tyr Asp Gln Lys Ser Gln Glu Val Glu Asp Lys 
            500                 505                 510         


Thr Lys Glu Tyr Glu Leu Leu Ser Asp Glu Leu Asn Gln Lys Ser Ala 
        515                 520                 525             


Thr Leu Ala Ser Ile Asp Ala Glu Leu Gln Lys Leu Lys Glu Met Thr 
    530                 535                 540                 


Asn His Gln Lys Lys Arg Ala Ala Glu Met Met Ala Ser Leu Leu Lys 
545                 550                 555                 560 


Asp Leu Ala Glu Ile Gly Ile Ala Val Gly Asn Asn Asp Val Lys Glu 
                565                 570                 575     


Asp Pro Lys Trp Glu Phe Pro Arg Lys Asn Leu Val Leu Gly Lys Thr 
            580                 585                 590         


Leu Gly Glu Gly Glu Phe Gly Lys Val Val Lys Ala Thr Ala Phe His 
        595                 600                 605             


Leu Lys Gly Arg Ala Gly Tyr Thr Thr Val Ala Val Lys Met Leu Lys 
    610                 615                 620                 


Glu Asn Ala Ser Pro Ser Glu Leu Arg Asp Leu Leu Ser Glu Phe Asn 
625                 630                 635                 640 


Val Leu Lys Gln Val Asn His Pro His Val Ile Lys Leu Tyr Gly Ala 
                645                 650                 655     


Cys Ser Gln Asp Gly Pro Leu Leu Leu Ile Val Glu Tyr Ala Lys Tyr 
            660                 665                 670         


Gly Ser Leu Arg Gly Phe Leu Arg Glu Ser Arg Lys Val Gly Pro Gly 
        675                 680                 685             


Tyr Leu Gly Ser Gly Gly Ser Arg Asn Ser Ser Ser Leu Asp His Pro 
    690                 695                 700                 


Asp Glu Arg Ala Leu Thr Met Gly Asp Leu Ile Ser Phe Ala Trp Gln 
705                 710                 715                 720 


Ile Ser Gln Gly Met Gln Tyr Leu Ala Glu Met Lys Leu Val His Arg 
                725                 730                 735     


Asp Leu Ala Ala Arg Asn Ile Leu Val Ala Glu Gly Arg Lys Met Lys 
            740                 745                 750         


Ile Ser Asp Phe Gly Leu Ser Arg Asp Val Tyr Glu Glu Asp Ser Tyr 
        755                 760                 765             


Val Lys Arg Ser Gln Gly Arg Ile Pro Val Lys Trp Met Ala Ile Glu 
    770                 775                 780                 


Ser Leu Phe Asp His Ile Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe 
785                 790                 795                 800 


Gly Val Leu Leu Trp Glu Ile Val Thr Leu Gly Gly Asn Pro Tyr Pro 
                805                 810                 815     


Gly Ile Pro Pro Glu Arg Leu Phe Asn Leu Leu Lys Thr Gly His Arg 
            820                 825                 830         


Met Glu Arg Pro Asp Asn Cys Ser Glu Glu Met Tyr Arg Leu Met Leu 
        835                 840                 845             


Gln Cys Trp Lys Gln Glu Pro Asp Lys Arg Pro Val Phe Ala Asp Ile 
    850                 855                 860                 


Ser Lys Asp Leu Glu Lys Met Met Val Lys Arg Arg Asp Tyr Leu Asp 
865                 870                 875                 880 


Leu Ala Ala Ser Thr Pro Ser Asp Ser Leu Ile Tyr Asp Asp Gly Leu 
                885                 890                 895     


Ser Glu Glu Glu Thr Pro Leu Val Asp Cys Asn Asn Ala Pro Leu Pro 
            900                 905                 910         


Arg Ala Leu Pro Ser Thr Trp Ile Glu Asn Lys Leu Tyr Gly Met Ser 
        915                 920                 925             


Asp Pro Asn Trp Pro Gly Glu Ser Pro Val Pro Leu Thr Arg Ala Asp 
    930                 935                 940                 


Gly Thr Asn Thr Gly Phe Pro Arg Tyr Pro Asn Asp Ser Val Tyr Ala 
945                 950                 955                 960 


Asn Trp Met Leu Ser Pro Ser Ala Ala Lys Leu Met Asp Thr Phe Asp 
                965                 970                 975     


Ser 
    


<210> 3
<211> 3303
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (1)..(3300)

<400> 3
atg gcg aag gcg acg tcc ggt gcc gcg ggg ctg cgt ctg ctg ttg ctg         48
Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu           
1               5                   10                  15                

ctg ctg ctg ccg ctg cta ggc aaa gtg gca ttg ggc ctc tac ttc tcg         96
Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser           
            20                  25                  30                    

agg gat gct tac tgg gag aag ctg tat gtg gac cag gca gcc ggc acg        144
Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr           
        35                  40                  45                        

ccc ttg ctg tac gtc cat gcc ctg cgg gac gcc cct gag gag gtg ccc        192
Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro           
    50                  55                  60                            

agc ttc cgc ctg ggc cag cat ctc tac ggc acg tac cgc aca cgg ctg        240
Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu           
65                  70                  75                  80            

cat gag aac aac tgg atc tgc atc cag gag gac acc ggc ctc ctc tac        288
His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr           
                85                  90                  95                

ctt aac cgg agc ctg gac cat agc tcc tgg gag aag ctc agt gtc cgc        336
Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg           
            100                 105                 110                   

aac cgc ggc ttt ccc ctg ctc acc gtc tac ctc aag gtc ttc ctg tca        384
Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser           
        115                 120                 125                       

ccc aca tcc ctt cgt gag ggc gag tgc cag tgg cca ggc tgt gcc cgc        432
Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg           
    130                 135                 140                           

gta tac ttc tcc ttc ttc aac acc tcc ttt cca gcc tgc agc tcc ctc        480
Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu           
145                 150                 155                 160           

aag ccc cgg gag ctc tgc ttc cca gag aca agg ccc tcc ttc cgc att        528
Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile           
                165                 170                 175               

cgg gag aac cga ccc cca ggc acc ttc cac cag ttc cgc ctg ctg cct        576
Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro           
            180                 185                 190                   

gtg cag ttc ttg tgc ccc aac atc agc gtg gcc tac agg ctc ctg gag        624
Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu           
        195                 200                 205                       

ggt gag ggt ctg ccc ttc cgc tgc gcc ccg gac agc ctg gag gtg agc        672
Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser           
    210                 215                 220                           

acg cgc tgg gcc ctg gac cgc gag cag cgg gag aag tac gag ctg gtg        720
Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val           
225                 230                 235                 240           

gcc gtg tgc acc gtg cac gcc ggc gcg cgc gag gag gtg gtg atg gtg        768
Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val           
                245                 250                 255               

ccc ttc ccg gtg acc gtg tac gac gag gac gac tcg gcg ccc acc ttc        816
Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe           
            260                 265                 270                   

ccc gcg ggc gtc gac acc gcc agc gcc gtg gtg gag ttc aag cgg aag        864
Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys           
        275                 280                 285                       

gag gac acc gtg gtg gcc acg ctg cgt gtc ttc gat gca gac gtg gta        912
Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val           
    290                 295                 300                           

cct gca tca ggg gag ctg gtg agg cgg tac aca agc acg ctg ctc ccc        960
Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro           
305                 310                 315                 320           

ggg gac acc tgg gcc cag cag acc ttc cgg gtg gaa cac tgg ccc aac       1008
Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn           
                325                 330                 335               

gag acc tcg gtc cag gcc aac ggc agc ttc gtg cgg gcg acc gta cat       1056
Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His           
            340                 345                 350                   

gac tat agg ctg gtt ctc aac cgg aac ctc tcc atc tcg gag aac cgc       1104
Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg           
        355                 360                 365                       

acc atg cag ctg gcg gtg ctg gtc aat gac tca gac ttc cag ggc cca       1152
Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro           
    370                 375                 380                           

gga gcg ggc gtc ctc ttg ctc cac ttc aac gtg tcg gtg ctg ccg gtc       1200
Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val           
385                 390                 395                 400           

agc ctg cac ctg ccc agt acc tac tcc ctc tcc gtg agc agg agg gct       1248
Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala           
                405                 410                 415               

cgc cga ttt gcc cag atc ggg aaa gtc tgt gtg gaa aac tgc cag gca       1296
Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala           
            420                 425                 430                   

ttc agt ggc atc aac gtc cag tac aag ctg cat tcc tct ggt gcc aac       1344
Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn           
        435                 440                 445                       

tgc agc acg cta ggg gtg gtc acc tca gcc gag gac acc tcg ggg atc       1392
Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile           
    450                 455                 460                           

ctg ttt gtg aat gac acc aag gcc ctg cgg cgg ccc aag tgt gcc gaa       1440
Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu           
465                 470                 475                 480           

ctt cac tac atg gtg gtg gcc acc gac cag cag acc tct agg cag gcc       1488
Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala           
                485                 490                 495               

cag gcc cag ctg ctt gta aca gtg gag ggg tca tat gtg gcc gag gag       1536
Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu           
            500                 505                 510                   

gcg ggc tgc ccc ctg tcc tgt gca gtc agc aag aga cgg ctg gag tgt       1584
Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys           
        515                 520                 525                       

gag gag tgt ggc ggc ctg ggc tcc cca aca ggc agg tgt gag tgg agg       1632
Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg           
    530                 535                 540                           

caa gga gat ggc aaa ggg atc acc agg aac ttc tcc acc tgc tct ccc       1680
Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro           
545                 550                 555                 560           

agc acc aag acc tgc ccc gac ggc cac tgc gat gtt gtg gag acc caa       1728
Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln           
                565                 570                 575               

gac atc aac att tgc cct cag gac tgc ctc cgg ggc agc att gtt ggg       1776
Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly           
            580                 585                 590                   

gga cac gag cct ggg gag ccc cgg ggg att aaa gct ggc tat ggc acc       1824
Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr           
        595                 600                 605                       

tgc aac tgc ttc cct gag gag gag aag tgc ttc tgc gag ccc gaa gac       1872
Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp           
    610                 615                 620                           

atc cag gat cca ctg tgc gac gag ctg tgc cgc acg gtg atc gca gcc       1920
Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala           
625                 630                 635                 640           

gct gtc ctc ttc tcc ttc atc gtc tcg gtg ctg ctg tct gcc ttc tgc       1968
Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys           
                645                 650                 655               

atc cac tgc tac cac aag ttt gcc cac aag cca ccc atc tcc tca gct       2016
Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala           
            660                 665                 670                   

gag atg acc ttc cgg agg ccc gcc cag gcc ttc ccg gtc agc tac tcc       2064
Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser           
        675                 680                 685                       

tct tcc ggt gcc cgc cgg ccc tcg ctg gac tcc atg gag aac cag gtc       2112
Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val           
    690                 695                 700                           

tcc gtg gat gcc ttc aag atc ctg cag cct gag gga act ggc atg ata       2160
Ser Val Asp Ala Phe Lys Ile Leu Gln Pro Glu Gly Thr Gly Met Ile           
705                 710                 715                 720           

gat gaa gag ttc act gtt gca aga ctc tac att agc aaa atg aag tca       2208
Asp Glu Glu Phe Thr Val Ala Arg Leu Tyr Ile Ser Lys Met Lys Ser           
                725                 730                 735               

gaa gta aaa acc atg gtg aaa cgt tgc aag cag tta gaa agc aca caa       2256
Glu Val Lys Thr Met Val Lys Arg Cys Lys Gln Leu Glu Ser Thr Gln           
            740                 745                 750                   

act gag agc aac aaa aaa atg gaa gaa aat gaa aag gag tta gca gca       2304
Thr Glu Ser Asn Lys Lys Met Glu Glu Asn Glu Lys Glu Leu Ala Ala           
        755                 760                 765                       

tgt cag ctt cgt atc tct caa cat gaa gcc aaa atc aag tca ttg act       2352
Cys Gln Leu Arg Ile Ser Gln His Glu Ala Lys Ile Lys Ser Leu Thr           
    770                 775                 780                           

gaa tac ctt caa aat gtg gaa caa aag aaa aga cag ttg gag gaa tct       2400
Glu Tyr Leu Gln Asn Val Glu Gln Lys Lys Arg Gln Leu Glu Glu Ser           
785                 790                 795                 800           

gtc gat gcc ctc agt gaa gaa cta gtc cag ctt cga gca caa gag aaa       2448
Val Asp Ala Leu Ser Glu Glu Leu Val Gln Leu Arg Ala Gln Glu Lys           
                805                 810                 815               

gtc cat gaa atg gaa aag gag cac tta aat aag gtt cag act gca aat       2496
Val His Glu Met Glu Lys Glu His Leu Asn Lys Val Gln Thr Ala Asn           
            820                 825                 830                   

gaa gtt aag caa gct gtt gaa cag cag atc cag agc cat aga gaa act       2544
Glu Val Lys Gln Ala Val Glu Gln Gln Ile Gln Ser His Arg Glu Thr           
        835                 840                 845                       

cat caa aaa cag atc agt agt ttg aga gat gaa gta gaa gca aaa gca       2592
His Gln Lys Gln Ile Ser Ser Leu Arg Asp Glu Val Glu Ala Lys Ala           
    850                 855                 860                           

aaa ctt att act gat ctt caa gac caa aac cag aaa atg atg tta gag       2640
Lys Leu Ile Thr Asp Leu Gln Asp Gln Asn Gln Lys Met Met Leu Glu           
865                 870                 875                 880           

cag gaa cgt cta aga gta gaa cat gag aag ttg aaa gcc aca gat cag       2688
Gln Glu Arg Leu Arg Val Glu His Glu Lys Leu Lys Ala Thr Asp Gln           
                885                 890                 895               

gaa aag agc aga aaa cta cat gaa ctt acg gtt atg caa gat aga cga       2736
Glu Lys Ser Arg Lys Leu His Glu Leu Thr Val Met Gln Asp Arg Arg           
            900                 905                 910                   

gaa caa gca aga caa gac ttg aag ggt ttg gaa gag aca gtg gca aaa       2784
Glu Gln Ala Arg Gln Asp Leu Lys Gly Leu Glu Glu Thr Val Ala Lys           
        915                 920                 925                       

gaa ctt cag act tta cac aac ctg cgc aaa ctc ttt gtt cag gac ctg       2832
Glu Leu Gln Thr Leu His Asn Leu Arg Lys Leu Phe Val Gln Asp Leu           
    930                 935                 940                           

gct aca aga gtt aaa aag agt gct gag att gat tct gat gac acc gga       2880
Ala Thr Arg Val Lys Lys Ser Ala Glu Ile Asp Ser Asp Asp Thr Gly           
945                 950                 955                 960           

ggc agc gct gct cag aag caa aaa atc tcc ttt ctt gaa aat aat ctt       2928
Gly Ser Ala Ala Gln Lys Gln Lys Ile Ser Phe Leu Glu Asn Asn Leu           
                965                 970                 975               

gaa cag ctc act aaa gtg cac aaa cag ttg gta cgt gat aat gca gat       2976
Glu Gln Leu Thr Lys Val His Lys Gln Leu Val Arg Asp Asn Ala Asp           
            980                 985                 990                   

ctc cgc tgt gaa ctt cct aag ttg  gaa aag cga ctt cga  gct aca gct     3024
Leu Arg Cys Glu Leu Pro Lys Leu  Glu Lys Arg Leu Arg  Ala Thr Ala         
        995                 1000                 1005                     

gag aga  gtg aaa gct ttg gaa  tca gca ctg aaa gaa  gct aaa gaa        3069
Glu Arg  Val Lys Ala Leu Glu  Ser Ala Leu Lys Glu  Ala Lys Glu            
    1010                 1015                 1020                        

aat gca  tct cgt gat cgc aaa  cgc tat cag caa gaa  gta gat cgc        3114
Asn Ala  Ser Arg Asp Arg Lys  Arg Tyr Gln Gln Glu  Val Asp Arg            
    1025                 1030                 1035                        

ata aag  gaa gca gtc agg tca  aag aat atg gcc aga  aga ggg cat        3159
Ile Lys  Glu Ala Val Arg Ser  Lys Asn Met Ala Arg  Arg Gly His            
    1040                 1045                 1050                        

tct gca  cag att gct aaa cct  att cgt ccc ggg caa  cat cca gca        3204
Ser Ala  Gln Ile Ala Lys Pro  Ile Arg Pro Gly Gln  His Pro Ala            
    1055                 1060                 1065                        

gct tct  cca act cac cca agt  gca att cgt gga gga  ggt gca ttt        3249
Ala Ser  Pro Thr His Pro Ser  Ala Ile Arg Gly Gly  Gly Ala Phe            
    1070                 1075                 1080                        

gtt cag  aac agc cag cca gtg  gca gtg cga ggt gga  gga ggc aaa        3294
Val Gln  Asn Ser Gln Pro Val  Ala Val Arg Gly Gly  Gly Gly Lys            
    1085                 1090                 1095                        

caa gtg  taa                                                          3303
Gln Val                                                                   
    1100                                                                  


<210> 4
<211> 1100
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser 
            20                  25                  30          


Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr 
        35                  40                  45              


Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro 
    50                  55                  60                  


Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu 
65                  70                  75                  80  


His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr 
                85                  90                  95      


Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg 
            100                 105                 110         


Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser 
        115                 120                 125             


Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg 
    130                 135                 140                 


Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu 
145                 150                 155                 160 


Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile 
                165                 170                 175     


Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro 
            180                 185                 190         


Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu 
        195                 200                 205             


Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser 
    210                 215                 220                 


Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val 
225                 230                 235                 240 


Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val 
                245                 250                 255     


Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe 
            260                 265                 270         


Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys 
        275                 280                 285             


Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val 
    290                 295                 300                 


Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro 
305                 310                 315                 320 


Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn 
                325                 330                 335     


Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His 
            340                 345                 350         


Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg 
        355                 360                 365             


Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro 
    370                 375                 380                 


Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val 
385                 390                 395                 400 


Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala 
                405                 410                 415     


Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala 
            420                 425                 430         


Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn 
        435                 440                 445             


Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile 
    450                 455                 460                 


Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu 
465                 470                 475                 480 


Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala 
                485                 490                 495     


Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu 
            500                 505                 510         


Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys 
        515                 520                 525             


Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg 
    530                 535                 540                 


Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro 
545                 550                 555                 560 


Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln 
                565                 570                 575     


Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly 
            580                 585                 590         


Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr 
        595                 600                 605             


Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp 
    610                 615                 620                 


Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala 
625                 630                 635                 640 


Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys 
                645                 650                 655     


Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala 
            660                 665                 670         


Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser 
        675                 680                 685             


Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val 
    690                 695                 700                 


Ser Val Asp Ala Phe Lys Ile Leu Gln Pro Glu Gly Thr Gly Met Ile 
705                 710                 715                 720 


Asp Glu Glu Phe Thr Val Ala Arg Leu Tyr Ile Ser Lys Met Lys Ser 
                725                 730                 735     


Glu Val Lys Thr Met Val Lys Arg Cys Lys Gln Leu Glu Ser Thr Gln 
            740                 745                 750         


Thr Glu Ser Asn Lys Lys Met Glu Glu Asn Glu Lys Glu Leu Ala Ala 
        755                 760                 765             


Cys Gln Leu Arg Ile Ser Gln His Glu Ala Lys Ile Lys Ser Leu Thr 
    770                 775                 780                 


Glu Tyr Leu Gln Asn Val Glu Gln Lys Lys Arg Gln Leu Glu Glu Ser 
785                 790                 795                 800 


Val Asp Ala Leu Ser Glu Glu Leu Val Gln Leu Arg Ala Gln Glu Lys 
                805                 810                 815     


Val His Glu Met Glu Lys Glu His Leu Asn Lys Val Gln Thr Ala Asn 
            820                 825                 830         


Glu Val Lys Gln Ala Val Glu Gln Gln Ile Gln Ser His Arg Glu Thr 
        835                 840                 845             


His Gln Lys Gln Ile Ser Ser Leu Arg Asp Glu Val Glu Ala Lys Ala 
    850                 855                 860                 


Lys Leu Ile Thr Asp Leu Gln Asp Gln Asn Gln Lys Met Met Leu Glu 
865                 870                 875                 880 


Gln Glu Arg Leu Arg Val Glu His Glu Lys Leu Lys Ala Thr Asp Gln 
                885                 890                 895     


Glu Lys Ser Arg Lys Leu His Glu Leu Thr Val Met Gln Asp Arg Arg 
            900                 905                 910         


Glu Gln Ala Arg Gln Asp Leu Lys Gly Leu Glu Glu Thr Val Ala Lys 
        915                 920                 925             


Glu Leu Gln Thr Leu His Asn Leu Arg Lys Leu Phe Val Gln Asp Leu 
    930                 935                 940                 


Ala Thr Arg Val Lys Lys Ser Ala Glu Ile Asp Ser Asp Asp Thr Gly 
945                 950                 955                 960 


Gly Ser Ala Ala Gln Lys Gln Lys Ile Ser Phe Leu Glu Asn Asn Leu 
                965                 970                 975     


Glu Gln Leu Thr Lys Val His Lys Gln Leu Val Arg Asp Asn Ala Asp 
            980                 985                 990         


Leu Arg Cys Glu Leu Pro Lys Leu  Glu Lys Arg Leu Arg  Ala Thr Ala 
        995                 1000                 1005             


Glu Arg  Val Lys Ala Leu Glu  Ser Ala Leu Lys Glu  Ala Lys Glu 
    1010                 1015                 1020             


Asn Ala  Ser Arg Asp Arg Lys  Arg Tyr Gln Gln Glu  Val Asp Arg 
    1025                 1030                 1035             


Ile Lys  Glu Ala Val Arg Ser  Lys Asn Met Ala Arg  Arg Gly His 
    1040                 1045                 1050             


Ser Ala  Gln Ile Ala Lys Pro  Ile Arg Pro Gly Gln  His Pro Ala 
    1055                 1060                 1065             


Ala Ser  Pro Thr His Pro Ser  Ala Ile Arg Gly Gly  Gly Ala Phe 
    1070                 1075                 1080             


Val Gln  Asn Ser Gln Pro Val  Ala Val Arg Gly Gly  Gly Gly Lys 
    1085                 1090                 1095             


Gln Val  
    1100 


<210> 5
<211> 200
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (16)..(185)
<223> a, c, t, g, unknown or other

<400> 5
atcgcaccag cgtgtnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn       60

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      180

nnnnncactg cggctcctca                                                  200


<210> 6
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Lys Val Asp Asn Asn Gly Val Ala Ile Gly Ile Glu Ala Leu Asp Lys 
1               5                   10                  15      


<210> 7
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Glu Asp Pro Lys Trp Glu Phe Pro Arg Lys Asn Leu Val Leu Gly Lys 
1               5                   10                  15      


Thr 
    


<210> 8
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
tgtaaaggag gatc                                                         14


<210> 9
<211> 976
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Met Ala Asp Leu Ala Glu Cys Asn Ile Lys Val Met Cys Arg Phe Arg 
1               5                   10                  15      


Pro Leu Asn Glu Ser Glu Val Asn Arg Gly Asp Lys Tyr Ile Ala Lys 
            20                  25                  30          


Phe Gln Gly Glu Asp Thr Val Val Ile Ala Ser Lys Pro Tyr Ala Phe 
        35                  40                  45              


Asp Arg Val Phe Gln Ser Ser Thr Ser Gln Glu Gln Val Tyr Asn Asp 
    50                  55                  60                  


Cys Ala Lys Lys Ile Val Lys Asp Val Leu Glu Gly Tyr Asn Gly Thr 
65                  70                  75                  80  


Ile Phe Ala Tyr Gly Gln Thr Ser Ser Gly Lys Thr His Thr Met Glu 
                85                  90                  95      


Gly Lys Leu His Asp Pro Glu Gly Met Gly Ile Ile Pro Arg Ile Val 
            100                 105                 110         


Gln Asp Ile Phe Asn Tyr Ile Tyr Ser Met Asp Glu Asn Leu Glu Phe 
        115                 120                 125             


His Ile Lys Val Ser Tyr Phe Glu Ile Tyr Leu Asp Lys Ile Arg Asp 
    130                 135                 140                 


Leu Leu Asp Val Ser Lys Thr Asn Leu Ser Val His Glu Asp Lys Asn 
145                 150                 155                 160 


Arg Val Pro Tyr Val Lys Gly Cys Thr Glu Arg Phe Val Cys Ser Pro 
                165                 170                 175     


Asp Glu Val Met Asp Thr Ile Asp Glu Gly Lys Ser Asn Arg His Val 
            180                 185                 190         


Ala Val Thr Asn Met Asn Glu His Ser Ser Arg Ser His Ser Ile Phe 
        195                 200                 205             


Leu Ile Asn Val Lys Gln Glu Asn Thr Gln Thr Glu Gln Lys Leu Ser 
    210                 215                 220                 


Gly Lys Leu Tyr Leu Val Asp Leu Ala Gly Ser Glu Lys Val Ser Lys 
225                 230                 235                 240 


Thr Gly Ala Glu Gly Ala Val Leu Asp Glu Ala Lys Asn Ile Asn Lys 
                245                 250                 255     


Ser Leu Ser Ala Leu Gly Asn Val Ile Ser Ala Leu Ala Glu Gly Ser 
            260                 265                 270         


Thr Tyr Val Pro Tyr Arg Asp Ser Lys Met Thr Arg Ile Leu Gln Asp 
        275                 280                 285             


Ser Leu Gly Gly Asn Cys Arg Thr Thr Ile Ile Cys Cys Ser Pro Ser 
    290                 295                 300                 


Ser Tyr Asn Glu Ser Glu Thr Lys Ser Thr Leu Leu Phe Gly Gln Arg 
305                 310                 315                 320 


Ala Lys Thr Ile Lys Asn Thr Val Cys Val Asn Val Glu Leu Thr Ala 
                325                 330                 335     


Glu Gln Trp Lys Lys Lys Tyr Glu Lys Glu Lys Glu Lys Asn Lys Ile 
            340                 345                 350         


Leu Arg Asn Thr Ile Gln Trp Leu Glu Asn Glu Leu Asn Arg Trp Arg 
        355                 360                 365             


Asn Gly Glu Thr Val Pro Ile Asp Glu Gln Phe Asp Lys Glu Lys Ala 
    370                 375                 380                 


Asn Leu Glu Ala Phe Thr Val Asp Lys Asp Ile Thr Leu Thr Asn Asp 
385                 390                 395                 400 


Lys Pro Ala Thr Ala Ile Gly Val Ile Gly Asn Phe Thr Asp Ala Glu 
                405                 410                 415     


Arg Arg Lys Cys Glu Glu Glu Ile Ala Lys Leu Tyr Lys Gln Leu Asp 
            420                 425                 430         


Asp Lys Asp Glu Glu Ile Asn Gln Gln Ser Gln Leu Val Glu Lys Leu 
        435                 440                 445             


Lys Thr Gln Met Leu Asp Gln Glu Glu Leu Leu Ala Ser Thr Arg Arg 
    450                 455                 460                 


Asp Gln Asp Asn Met Gln Ala Glu Leu Asn Arg Leu Gln Ala Glu Asn 
465                 470                 475                 480 


Asp Ala Ser Lys Glu Glu Val Lys Glu Val Leu Gln Ala Leu Glu Glu 
                485                 490                 495     


Leu Ala Val Asn Tyr Asp Gln Lys Ser Gln Glu Val Glu Asp Lys Thr 
            500                 505                 510         


Lys Glu Tyr Glu Leu Leu Ser Asp Glu Leu Asn Gln Lys Ser Ala Thr 
        515                 520                 525             


Leu Ala Ser Ile Asp Ala Glu Leu Gln Lys Leu Lys Glu Met Thr Asn 
    530                 535                 540                 


His Gln Lys Lys Arg Ala Ala Glu Met Met Ala Ser Leu Leu Lys Asp 
545                 550                 555                 560 


Leu Ala Glu Ile Gly Ile Ala Val Gly Asn Asn Asp Val Lys Glu Asp 
                565                 570                 575     


Pro Lys Trp Glu Phe Pro Arg Lys Asn Leu Val Leu Gly Lys Thr Leu 
            580                 585                 590         


Gly Glu Gly Glu Phe Gly Lys Val Val Lys Ala Thr Ala Phe His Leu 
        595                 600                 605             


Lys Gly Arg Ala Gly Tyr Thr Thr Val Ala Val Lys Met Leu Lys Glu 
    610                 615                 620                 


Asn Ala Ser Pro Ser Glu Leu Arg Asp Leu Leu Ser Glu Phe Asn Val 
625                 630                 635                 640 


Leu Lys Gln Val Asn His Pro His Val Ile Lys Leu Tyr Gly Ala Cys 
                645                 650                 655     


Ser Gln Asp Gly Pro Leu Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly 
            660                 665                 670         


Ser Leu Arg Gly Phe Leu Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr 
        675                 680                 685             


Leu Gly Ser Gly Gly Ser Arg Asn Ser Ser Ser Leu Asp His Pro Asp 
    690                 695                 700                 


Glu Arg Ala Leu Thr Met Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile 
705                 710                 715                 720 


Ser Gln Gly Met Gln Tyr Leu Ala Glu Met Lys Leu Val His Arg Asp 
                725                 730                 735     


Leu Ala Ala Arg Asn Ile Leu Val Ala Glu Gly Arg Lys Met Lys Ile 
            740                 745                 750         


Ser Asp Phe Gly Leu Ser Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val 
        755                 760                 765             


Lys Arg Ser Gln Gly Arg Ile Pro Val Lys Trp Met Ala Ile Glu Ser 
    770                 775                 780                 


Leu Phe Asp His Ile Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly 
785                 790                 795                 800 


Val Leu Leu Trp Glu Ile Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly 
                805                 810                 815     


Ile Pro Pro Glu Arg Leu Phe Asn Leu Leu Lys Thr Gly His Arg Met 
            820                 825                 830         


Glu Arg Pro Asp Asn Cys Ser Glu Glu Met Tyr Arg Leu Met Leu Gln 
        835                 840                 845             


Cys Trp Lys Gln Glu Pro Asp Lys Arg Pro Val Phe Ala Asp Ile Ser 
    850                 855                 860                 


Lys Asp Leu Glu Lys Met Met Val Lys Arg Arg Asp Tyr Leu Asp Leu 
865                 870                 875                 880 


Ala Ala Ser Thr Pro Ser Asp Ser Leu Ile Tyr Asp Asp Gly Leu Ser 
                885                 890                 895     


Glu Glu Glu Thr Pro Leu Val Asp Cys Asn Asn Ala Pro Leu Pro Arg 
            900                 905                 910         


Ala Leu Pro Ser Thr Trp Ile Glu Asn Lys Leu Tyr Gly Met Ser Asp 
        915                 920                 925             


Pro Asn Trp Pro Gly Glu Ser Pro Val Pro Leu Thr Arg Ala Asp Gly 
    930                 935                 940                 


Thr Asn Thr Gly Phe Pro Arg Tyr Pro Asn Asp Ser Val Tyr Ala Asn 
945                 950                 955                 960 


Trp Met Leu Ser Pro Ser Ala Ala Lys Leu Met Asp Thr Phe Asp Ser 
                965                 970                 975     



