                               SEQUENCE LISTING	

<110> BOARD OF REGENTS, THE UNIVERSITY OF TEXAS
 
<120> ANTI-OX40 ANTIBODIES USEFUL TO TREAT CANCER

<130> 07P53WO3

<140>
<141>

<150> PCT/US11/48752
<151> 2011-08-23

<160> 47   

<170> PatentIn version 3.5

<210> 1
<211> 5
<212> PRT
<213> Mus sp.

<400> 1
Asp Tyr Ser Met His 
1               5   


<210> 2
<211> 17
<212> PRT
<213> Mus sp.

<400> 2
Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 3
<211> 13
<212> PRT
<213> Mus sp.

<400> 3
Pro Tyr Tyr Asp Tyr Val Ser Tyr Tyr Ala Met Asp Tyr 
1               5                   10              


<210> 4
<211> 122
<212> PRT
<213> Mus sp.

<400> 4
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Asn Pro Tyr Tyr Asp Tyr Val Ser Tyr Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly His Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210> 5
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Pro Tyr Tyr Asp Tyr Val Ser Tyr Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210> 6
<211> 458
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 6
actagtacca ccatggcttg ggtgtggacc ttgctattcc tgatggcagc tgcccaaagt       60

atccaagcac aggttcagtt ggtgcagtct ggatctgagc tgaagaagcc tggagcctca      120

gtcaaggttt cctgcaaggc ttctggttat accttcacag actattcaat gcactgggtg      180

cgacaggctc caggacaagg tttaaagtgg atgggctgga taaacactga gactggtgag      240

ccaacatatg cagatgactt caagggacgg tttgtcttct ctttggacac ctctgtcagc      300

actgcctatt tgcagatcag cagcctcaaa gctgaggaca cggctgtgta ttactgtgct      360

aatccctact atgattacgt ctcttactat gctatggact actggggtca gggaaccacg      420

gtcaccgtct cctcaggtaa gaatggcctc tcaagctt                              458


<210> 7
<211> 11
<212> PRT
<213> Mus sp.

<400> 7
Lys Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210> 8
<211> 7
<212> PRT
<213> Mus sp.

<400> 8
Ser Ala Ser Tyr Leu Tyr Thr 
1               5           


<210> 9
<211> 9
<212> PRT
<213> Mus sp.

<400> 9
Gln Gln His Tyr Ser Thr Pro Arg Thr 
1               5                   


<210> 10
<211> 107
<212> PRT
<213> Mus sp.

<400> 10
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Arg 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Leu Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 11
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Leu Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 12
<211> 416
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 12
gctagcacca ccatggagtc acagattcag gtctttgtat tcgtgtttct ctggttgtct       60

ggtgttgacg gagacattca gatgacccag tctccatcct ccctgtccgc atcagtggga      120

gacagggtca ccatcacctg caaggccagt caggatgtga gtactgctgt agcctggtat      180

caacagaaac caggaaaagc ccctaaacta ctgatttact cggcatccta cctctacact      240

ggagtccctt cacgcttcag tggcagtgga tctgggacgg atttcacttt caccatcagc      300

agtctgcagc ctgaagacat tgcaacatat tactgtcagc aacattatag tactcctcgg      360

acgttcggtc agggcaccaa gctggaaatc aaacgtaagt agaatccaaa gaattc          416


<210> 13
<211> 5
<212> PRT
<213> Mus sp.

<400> 13
Ser His Asp Met Ser 
1               5   


<210> 14
<211> 17
<212> PRT
<213> Mus sp.

<400> 14
Ala Ile Asn Ser Asp Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Met Glu 
1               5                   10                  15      


Arg 
    


<210> 15
<211> 11
<212> PRT
<213> Mus sp.

<400> 15
His Tyr Asp Asp Tyr Tyr Ala Trp Phe Ala Tyr 
1               5                   10      


<210> 16
<211> 120
<212> PRT
<213> Mus sp.

<400> 16
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Glu Ser Asn Glu Tyr Glu Phe Pro Ser His 
            20                  25                  30          


Asp Met Ser Trp Val Arg Lys Thr Pro Glu Lys Arg Leu Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Asn Ser Asp Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Met 
    50                  55                  60                  


Glu Arg Arg Phe Ile Ile Ser Arg Asp Asn Thr Lys Lys Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Tyr Asp Asp Tyr Tyr Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210> 17
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Tyr Glu Phe Pro Ser His 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Asn Ser Asp Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Met 
    50                  55                  60                  


Glu Arg Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Tyr Asp Asp Tyr Tyr Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210> 18
<211> 451
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 18
actagtacca ccatggactt cgggctcagc ttggttttcc ttgtccttat tttaaaaagt       60

gtacagtgtg aggtgcagct ggtggagtct gggggaggct tagtgcagcc tggagggtcc      120

ctgagactct cctgtgcagc ctctgaatac gagttccctt cccatgacat gtcttgggtc      180

cgccaggctc cggggaaggg gctggagttg gtcgcagcca ttaatagtga tggtggtagc      240

acctactatc cagacaccat ggagagacga ttcaccatct ccagagacaa tgccaagaac      300

tcactgtacc tgcaaatgaa cagtctgagg gccgaggaca cagccgtgta ttactgtgca      360

agacactatg atgattacta cgcctggttt gcttactggg gccaagggac tatggtcact      420

gtctcttcag gtgagtccta acttcaagct t                                     451


<210> 19
<211> 15
<212> PRT
<213> Mus sp.

<400> 19
Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His 
1               5                   10                  15  


<210> 20
<211> 7
<212> PRT
<213> Mus sp.

<400> 20
Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210> 21
<211> 9
<212> PRT
<213> Mus sp.

<400> 21
Gln His Ser Arg Glu Leu Pro Leu Thr 
1               5                   


<210> 22
<211> 111
<212> PRT
<213> Mus sp.

<400> 22
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210> 23
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210> 24
<211> 428
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 24
gctagcacca ccatggagac agacacactc ctgttatggg tactgctgct ctgggttcca       60

ggttccactg gtgaaattgt gctgacacag tctcctgcta ccttatcttt gtctccaggg      120

gaaagggcca ccctctcatg cagggccagc aaaagtgtca gtacatctgg ctatagttat      180

atgcactggt accaacagaa accaggacag gctcccagac tcctcatcta tcttgcatcc      240

aacctagaat ctggggtccc tgccaggttc agtggcagtg ggtctgggac agacttcacc      300

ctcaccatca gcagcctaga gcctgaggat tttgcagttt attactgtca gcacagtagg      360

gagcttccgc tcacgttcgg cggagggacc aaggtcgaga tcaaacgtaa gtacactttt      420

ctgaattc                                                               428


<210> 25
<211> 5
<212> PRT
<213> Mus sp.

<400> 25
Asp Ala Trp Met Asp 
1               5   


<210> 26
<211> 19
<212> PRT
<213> Mus sp.

<400> 26
Glu Ile Arg Ser Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Asn Gly 
            


<210> 27
<211> 8
<212> PRT
<213> Mus sp.

<400> 27
Gly Glu Val Phe Tyr Phe Asp Tyr 
1               5               


<210> 28
<211> 414
<212> DNA
<213> Mus sp.

<400> 28
atgtacttgg gactgaacta tgtattcata gtttttctct taaatggtgt ccagagtgaa       60

gtgaagcttg aggagtctgg aggaggcttg gtgcaacctg gaggatccat gaaactctct      120

tgtgctgcct ctggattcac ttttagtgac gcctggatgg actgggtccg ccagtctcca      180

gagaaggggc ttgagtgggt tgctgaaatt agaagcaaag ctaataatca tgcaacatac      240

tatgctgagt ctgtgaatgg gaggttcacc atctcaagag atgattccaa aagtagtgtc      300

tacctgcaaa tgaacagctt aagagctgaa gacactggca tttattactg tacgtggggg      360

gaagtgttct actttgacta ctggggccaa ggcaccactc tcacagtctc ctca            414


<210> 29
<211> 138
<212> PRT
<213> Mus sp.

<400> 29
Met Tyr Leu Gly Leu Asn Tyr Val Phe Ile Val Phe Leu Leu Asn Gly 
1               5                   10                  15      


Val Gln Ser Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Ala Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Arg Ser Lys Ala Asn Asn His Ala Thr Tyr 
65                  70                  75                  80  


Tyr Ala Glu Ser Val Asn Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Ser Ser Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Gly Ile Tyr Tyr Cys Thr Trp Gly Glu Val Phe Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135             


<210> 30
<211> 448
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 30
actagtacca ccatgtactt gggactgaac tatgtattca tagtttttct cttaaatggt       60

gtccagagtg aagtgaagct ggaggagtct ggaggaggct tggtgcaacc tggaggatcc      120

atgaaactct cttgtgctgc ctctggattc acttttagtg acgcctggat ggactgggtc      180

cgccagtctc cagagaaggg gcttgagtgg gttgctgaaa ttagaagcaa agctaataat      240

catgcaacat actatgctga gtctgtgaat gggaggttca ccatctcaag agatgattcc      300

aaaagtagtg tctacctgca aatgaacagc ttaagagctg aagacactgg catttattac      360

tgtacgtggg gggaagtgtt ctactttgac tactggggcc aaggcaccac tctcacagtc      420

tcctcaggtg agtccttaaa acaagctt                                         448


<210> 31
<211> 138
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Met Tyr Leu Gly Leu Asn Tyr Val Phe Ile Val Phe Leu Leu Asn Gly 
1               5                   10                  15      


Val Gln Ser Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Ala Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Arg Ser Lys Ala Asn Asn His Ala Thr Tyr 
65                  70                  75                  80  


Tyr Ala Glu Ser Val Asn Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Ser Ser Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Gly Ile Tyr Tyr Cys Thr Trp Gly Glu Val Phe Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135             


<210> 32
<211> 11
<212> PRT
<213> Mus sp.

<400> 32
Lys Ser Ser Gln Asp Ile Asn Lys Tyr Ile Ala 
1               5                   10      


<210> 33
<211> 7
<212> PRT
<213> Mus sp.

<400> 33
Tyr Thr Ser Thr Leu Gln Pro 
1               5           


<210> 34
<211> 8
<212> PRT
<213> Mus sp.

<400> 34
Leu Gln Tyr Asp Asn Leu Leu Thr 
1               5               


<210> 35
<211> 378
<212> DNA
<213> Mus sp.

<400> 35
atgagaccgt ctattcagtt cctggggctc ttgttgttct ggcttcatgg tgctcagtgt       60

gacatccaga tgacacagtc tccatcctca ctgtctgcat ctctgggagg caaagtcacc      120

atcacttgca agtcaagcca agacattaac aagtatatag cttggtacca acacaagcct      180

ggaaaaggtc ctaggctgct catacattac acatctacat tacagccagg catcccatca      240

aggttcagtg gaagtgggtc tgggagagat tattccttca gcatcagcaa cctggagcct      300

gaagatattg caacttatta ttgtctacag tatgataatc ttctcacgtt cggtgctggg      360

accaagctgg agctgaaa                                                    378


<210> 36
<211> 126
<212> PRT
<213> Mus sp.

<400> 36
Met Arg Pro Ser Ile Gln Phe Leu Gly Leu Leu Leu Phe Trp Leu His 
1               5                   10                  15      


Gly Ala Gln Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys Ser Ser Gln Asp 
        35                  40                  45              


Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro 
    50                  55                  60                  


Arg Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser 
                85                  90                  95      


Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp 
            100                 105                 110         


Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125     


<210> 37
<211> 413
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 37
gctagcacca ccatgagacc gtctattcag ttcctggggc tcttgttgtt ctggcttcat       60

ggtgctcagt gtgacatcca gatgacacag tctccatcct cactgtctgc atctctggga      120

ggcaaagtca ccatcacttg caagtcaagc caagacatta acaagtatat agcttggtac      180

caacacaagc ctggaaaagg tcctaggctg ctcatacatt acacatctac attacagcca      240

ggcatcccat caaggttcag tggaagtggg tctgggagag attattcctt cagcatcagc      300

aacctggagc ctgaagatat tgcaacttat tattgtctac agtatgataa tcttctcacg      360

ttcggtgctg ggaccaagct ggagctgaaa cgtaagtaca cttttctgaa ttc             413


<210> 38
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Met Arg Pro Ser Ile Gln Phe Leu Gly Leu Leu Leu Phe Trp Leu His 
1               5                   10                  15      


Gly Ala Gln Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys Ser Ser Gln Asp 
        35                  40                  45              


Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro 
    50                  55                  60                  


Arg Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser 
                85                  90                  95      


Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp 
            100                 105                 110         


Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125     


<210> 39
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 39
cgctgttttg acctccatag                                                   20


<210> 40
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 40
tgaaagatga gctggaggac                                                   20


<210> 41
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 41
ctttcttgtc caccttggtg                                                   20


<210> 42
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 42
gctgtcctac agtcctcag                                                    19


<210> 43
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 43
acgtgccaag catcctcg                                                     18


<210> 44
<211> 1407
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 44
atgtacttgg gactgaacta tgtattcata gtttttctct taaatggtgt ccagagtgaa       60

gtgaagctgg aggagtctgg aggaggcttg gtgcaacctg gaggatccat gaaactctct      120

tgtgctgcct ctggattcac ttttagtgac gcctggatgg actgggtccg ccagtctcca      180

gagaaggggc ttgagtgggt tgctgaaatt agaagcaaag ctaataatca tgcaacatac      240

tatgctgagt ctgtgaatgg gaggttcacc atctcaagag atgattccaa aagtagtgtc      300

tacctgcaaa tgaacagctt aagagctgaa gacactggca tttattactg tacgtggggg      360

gaagtgttct actttgacta ctggggccaa ggcaccactc tcacagtctc ctcagcctcc      420

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      480

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      540

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      600

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      660

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      720

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      780

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      840

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      900

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      960

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1020

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1080

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1260

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1320

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1380

agcctctccc tgtctccggg taaatga                                         1407


<210> 45
<211> 469
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
Met Tyr Leu Gly Leu Asn Tyr Val Phe Ile Val Phe Leu Leu Asn Gly 
1               5                   10                  15      


Val Gln Ser Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Ala Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Arg Ser Lys Ala Asn Asn His Ala Thr Tyr 
65                  70                  75                  80  


Tyr Ala Glu Ser Val Asn Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Ser Ser Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Gly Ile Tyr Tyr Cys Thr Trp Gly Glu Val Phe Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Thr Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Lys 
465                 


<210> 46
<211> 702
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 46
atgagaccgt ctattcagtt cctggggctc ttgttgttct ggcttcatgg tgctcagtgt       60

gacatccaga tgacacagtc tccatcctca ctgtctgcat ctctgggagg caaagtcacc      120

atcacttgca agtcaagcca agacattaac aagtatatag cttggtacca acacaagcct      180

ggaaaaggtc ctaggctgct catacattac acatctacat tacagccagg catcccatca      240

aggttcagtg gaagtgggtc tgggagagat tattccttca gcatcagcaa cctggagcct      300

gaagatattg caacttatta ttgtctacag tatgataatc ttctcacgtt cggtgctggg      360

accaagctgg agctgaaacg aactgtggct gcaccatctg tcttcatctt cccgccatct      420

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      480

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      540

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      600

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      660

agctcgcccg tcacaaagag cttcaacagg ggagagtgtt ag                         702


<210> 47
<211> 233
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 47
Met Arg Pro Ser Ile Gln Phe Leu Gly Leu Leu Leu Phe Trp Leu His 
1               5                   10                  15      


Gly Ala Gln Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys Ser Ser Gln Asp 
        35                  40                  45              


Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro 
    50                  55                  60                  


Arg Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser 
                85                  90                  95      


Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp 
            100                 105                 110         


Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230
