                         SEQUENCE LISTING

<110>  Synapse B.V.
       Universiteit Maastricht
 
<120>  Thermostable inhibitors of activation of the blood clotting 
       system through contact with foreign surfaces

<130>  P6036535PCT

<160>  25    

<170>  PatentIn version 3.3

<210>  1
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide

<400>  1

Arg Val Cys Pro Arg Ile Leu Met Lys Cys Lys Lys Asp Ser Asp Cys 
1               5                   10                  15      


Leu Ala Glu Cys Val Cys Leu Glu His Gly Tyr Cys Gly 
            20                  25                  


<210>  2
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide

<400>  2

Arg Val Cys Pro Arg Ile Leu Met Glu Cys Lys Lys Asp Ser Asp Cys 
1               5                   10                  15      


Leu Ala Glu Cys Val Cys Leu Glu His Gly Tyr Cys Gly 
            20                  25                  


<210>  3
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide

<400>  3

His Glu Glu Arg Val Cys Pro Arg Ile Leu Met Lys Cys Lys Lys Asp 
1               5                   10                  15      


Ser Asp Cys Leu Ala Glu Cys Val Cys Leu Glu His Gly Tyr Cys Gly 
            20                  25                  30          


<210>  4
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide

<400>  4

Arg Val Cys Pro Lys Ile Leu Met Glu Cys Lys Lys Asp Ser Asp Cys 
1               5                   10                  15      


Leu Ala Glu Cys Ile Cys Leu Glu His Gly Tyr Cys Gly 
            20                  25                  


<210>  5
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide

<400>  5

His Glu Glu Arg Val Cys Pro Lys Ile Leu Met Glu Cys Lys Lys Asp 
1               5                   10                  15      


Ser Asp Cys Leu Ala Glu Cys Ile Cys Leu Glu His Gly Tyr Cys Gly 
            20                  25                  30          


<210>  6
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa at position 1 is K or R, preferably R

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa at position 5 is E or K, preferably K

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa at position 17 is I or V, preferably V

<400>  6

Xaa Ile Leu Met Xaa Cys Lys Lys Asp Ser Asp Cys Leu Ala Glu Cys 
1               5                   10                  15      


Xaa 
    


<210>  7
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa at position 5 is K or R, preferably R

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa at position 9 is E or K, preferably K

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa at position 21 is I or V, preferably V

<400>  7

Arg Val Cys Pro Xaa Ile Leu Met Xaa Cys Lys Lys Asp Ser Asp Cys 
1               5                   10                  15      


Leu Ala Glu Cys Xaa Cys Leu Glu His Gly Tyr Cys Gly 
            20                  25                  


<210>  8
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide

<400>  8

Arg Val Cys Gly Ile Gly Pro Arg Pro Arg Leu Pro Trp Pro Arg Ile 
1               5                   10                  15      


Leu Met Lys Cys Lys Lys Asp Ser Asp Cys Leu Ala Glu Cys Val Cys 
            20                  25                  30          


Leu Glu His Gly Tyr Cys Gly 
        35                  


<210>  9
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is R or an analog of R

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is E or K, preferably K

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is I or V, preferably V

<220>
<221>  misc_feature
<222>  (23)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<400>  9

Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys 
1               5                   10                  15      


Xaa Xaa Xaa Cys Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys Xaa 
            20                  25                  


<210>  10
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is R or an analog of R

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is E or K, preferably K

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is I or V, preferably V

<220>
<221>  misc_feature
<222>  (23)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<400>  10

Arg Xaa Cys Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys 
1               5                   10                  15      


Xaa Xaa Xaa Cys Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys Xaa 
            20                  25                  


<210>  11
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is R or an analog of R

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is E or K, preferably K

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is I or V, preferably V

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is I or V, preferably V

<220>
<221>  misc_feature
<222>  (23)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<400>  11

Xaa Val Cys Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys 
1               5                   10                  15      


Xaa Xaa Xaa Cys Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys Xaa 
            20                  25                  


<210>  12
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is R or an analog of R

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is E or K, preferably K

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is I or V, preferably V

<220>
<221>  misc_feature
<222>  (23)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<400>  12

Xaa Xaa Cys Pro Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys 
1               5                   10                  15      


Xaa Xaa Xaa Cys Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys Xaa 
            20                  25                  


<210>  13
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is E or K, preferably K

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is I or V, preferably V

<220>
<221>  misc_feature
<222>  (23)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<400>  13

Xaa Xaa Cys Xaa Arg Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys 
1               5                   10                  15      


Xaa Xaa Xaa Cys Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys Xaa 
            20                  25                  


<210>  14
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is R or an analog of R

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is E or K, preferably K

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is I or V, preferably V

<220>
<221>  misc_feature
<222>  (23)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<400>  14

Arg Val Cys Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys 
1               5                   10                  15      


Xaa Xaa Xaa Cys Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys Xaa 
            20                  25                  


<210>  15
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is R or an analog of R

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is E or K, preferably K

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is I or V, preferably V

<220>
<221>  misc_feature
<222>  (23)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

Arg Xaa Cys Pro Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys 
1               5                   10                  15      


Xaa Xaa Xaa Cys Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys Xaa 
            20                  25                  


<210>  16
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is E or K, preferably K

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is I or V, preferably V

<220>
<221>  misc_feature
<222>  (23)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<400>  16

Arg Xaa Cys Xaa Arg Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys 
1               5                   10                  15      


Xaa Xaa Xaa Cys Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys Xaa 
            20                  25                  


<210>  17
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is R or an analog of R

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is E or K, preferably K

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is I or V, preferably V

<220>
<221>  misc_feature
<222>  (23)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<400>  17

Xaa Val Cys Pro Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys 
1               5                   10                  15      


Xaa Xaa Xaa Cys Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys Xaa 
            20                  25                  


<210>  18
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is E or K, preferably K

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is I or V, preferably V

<220>
<221>  misc_feature
<222>  (23)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<400>  18

Xaa Val Cys Xaa Arg Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys 
1               5                   10                  15      


Xaa Xaa Xaa Cys Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys Xaa 
            20                  25                  


<210>  19
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is E or K, preferably K

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is I or V, preferably V

<220>
<221>  misc_feature
<222>  (23)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<400>  19

Xaa Xaa Cys Pro Arg Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys 
1               5                   10                  15      


Xaa Xaa Xaa Cys Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys Xaa 
            20                  25                  


<210>  20
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is E or K, preferably K

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is I or V, preferably V

<220>
<221>  misc_feature
<222>  (23)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<400>  20

Arg Xaa Cys Xaa Arg Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys 
1               5                   10                  15      


Xaa Xaa Xaa Cys Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys Xaa 
            20                  25                  


<210>  21
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is R or an analog of R

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is E or K, preferably K

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is I or V, preferably V

<220>
<221>  misc_feature
<222>  (23)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<400>  21

Arg Val Cys Pro Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys 
1               5                   10                  15      


Xaa Xaa Xaa Cys Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys Xaa 
            20                  25                  


<210>  22
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is E or K, preferably K

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is I or V, preferably V

<220>
<221>  misc_feature
<222>  (23)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<400>  22

Arg Val Cys Xaa Arg Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys 
1               5                   10                  15      


Xaa Xaa Xaa Cys Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys Xaa 
            20                  25                  


<210>  23
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is E or K, preferably K

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is I or V, preferably V

<220>
<221>  misc_feature
<222>  (23)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<400>  23

Xaa Val Cys Pro Arg Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys 
1               5                   10                  15      


Xaa Xaa Xaa Cys Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys Xaa 
            20                  25                  


<210>  24
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is E or K, preferably K

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is I or V, preferably V

<220>
<221>  misc_feature
<222>  (23)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<400>  24

Arg Xaa Cys Pro Arg Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys 
1               5                   10                  15      


Xaa Xaa Xaa Cys Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys Xaa 
            20                  25                  


<210>  25
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide


<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is E or K, preferably K

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is I or V, preferably V

<220>
<221>  misc_feature
<222>  (23)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<400>  25

Arg Val Cys Pro Arg Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys 
1               5                   10                  15      


Xaa Xaa Xaa Cys Xaa Cys Xaa Xaa Xaa Xaa Xaa Cys Xaa 
            20                  25                  


