                         SEQUENCE LISTING

<110>  Deutsches Krebsforschungszentrum
 
<120>  Means and Methods for Treating Angiogenesis-Related Diseases

<130>  DK10569PC

<160>  17     

<170>  PatentIn version 3.5

<210>  1
<211>  1527
<212>  PRT
<213>  mouse

<400>  1

Met Ala Pro Asp Pro Ser Arg Arg Leu Cys Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ser Cys Arg Leu Val Pro Ala Ser Ala Asp Gly Asn Ser Leu Ser 
            20                  25                  30          


Pro Leu Asn Pro Leu Val Trp Leu Trp Pro Pro Lys Thr Ser Asp Ser 
        35                  40                  45              


Leu Glu Gly Pro Val Ser Lys Pro Gln Asn Ser Ser Pro Val Gln Ser 
    50                  55                  60                  


Thr Glu Asn Pro Thr Thr His Val Val Pro Gln Asp Gly Leu Thr Glu 
65                  70                  75                  80  


Gln Gln Thr Thr Pro Ala Ser Ser Glu Leu Pro Pro Glu Glu Glu Glu 
                85                  90                  95      


Glu Glu Asp Gln Lys Ala Gly Gln Gly Gly Ser Pro Ala Thr Pro Ala 
            100                 105                 110         


Val Pro Ile Pro Leu Val Ala Pro Ala Ala Ser Pro Asp Met Lys Glu 
        115                 120                 125             


Glu Asn Val Ala Gly Val Gly Ala Lys Ile Leu Asn Val Ala Gln Gly 
    130                 135                 140                 


Ile Arg Ser Phe Val Gln Leu Trp Asp Glu Asp Ser Thr Ile Gly His 
145                 150                 155                 160 


Ser Ala Gly Thr Glu Val Pro Asp Ser Ser Ile Pro Thr Val Leu Pro 
                165                 170                 175     


Ser Pro Ala Glu Leu Ser Ser Ala Pro Gln Gly Ser Lys Thr Thr Leu 
            180                 185                 190         


Trp Leu Ser Ser Ala Ile Pro Ser Ser Pro Asp Ala Gln Thr Thr Glu 
        195                 200                 205             


Ala Gly Thr Leu Ala Val Pro Thr Gln Leu Pro Pro Phe Gln Ser Asn 
    210                 215                 220                 


Leu Gln Ala Pro Leu Gly Arg Pro Ser Ala Pro Pro Asp Phe Pro Glu 
225                 230                 235                 240 


Asn Val Ala Glu Glu Val Gly Leu Leu Gln Leu Leu Gly Asp Pro Leu 
                245                 250                 255     


Pro Glu Lys Ile Ser Gln Ile Asp Asp Pro His Val Gly Pro Ala Tyr 
            260                 265                 270         


Ile Phe Gly Pro Asp Ser Asn Ser Gly Gln Val Ala Gln Tyr His Phe 
        275                 280                 285             


Pro Lys Leu Phe Phe Arg Asp Phe Ser Leu Leu Phe His Val Arg Pro 
    290                 295                 300                 


Ala Thr Glu Ala Ala Gly Val Leu Phe Ala Ile Thr Asp Ala Ala Gln 
305                 310                 315                 320 


Val Val Val Ser Leu Gly Val Lys Leu Ser Glu Val Arg Asp Gly Gln 
                325                 330                 335     


Gln Asn Ile Ser Leu Leu Tyr Thr Glu Pro Gly Ala Ser Gln Thr Gln 
            340                 345                 350         


Thr Gly Ala Ser Phe Arg Leu Pro Ala Phe Val Gly Gln Trp Thr His 
        355                 360                 365             


Phe Ala Leu Ser Val Asp Gly Gly Ser Val Ala Leu Tyr Val Asp Cys 
    370                 375                 380                 


Glu Glu Phe Gln Arg Val Pro Phe Ala Arg Ala Ser Gln Gly Leu Glu 
385                 390                 395                 400 


Leu Glu Arg Gly Ala Gly Leu Phe Val Gly Gln Ala Gly Thr Ala Asp 
                405                 410                 415     


Pro Asp Lys Phe Gln Gly Met Ile Ser Glu Leu Lys Val Arg Lys Thr 
            420                 425                 430         


Pro Arg Val Ser Pro Val His Cys Leu Asp Glu Glu Asp Asp Asp Glu 
        435                 440                 445             


Asp Arg Ala Ser Gly Asp Phe Gly Ser Gly Phe Glu Glu Ser Ser Lys 
    450                 455                 460                 


Ser His Lys Glu Asp Thr Ser Leu Leu Pro Gly Leu Pro Gln Pro Pro 
465                 470                 475                 480 


Pro Val Thr Ser Pro Pro Leu Ala Gly Gly Ser Thr Thr Glu Asp Pro 
                485                 490                 495     


Arg Thr Glu Glu Thr Glu Glu Asp Ala Ala Val Asp Ser Ile Gly Ala 
            500                 505                 510         


Glu Thr Leu Pro Gly Thr Gly Ser Ser Gly Ala Trp Asp Glu Ala Ile 
        515                 520                 525             


Gln Asn Pro Gly Arg Gly Leu Ile Lys Gly Gly Met Lys Gly Gln Lys 
    530                 535                 540                 


Gly Glu Pro Gly Ala Gln Gly Pro Pro Gly Pro Ala Gly Pro Gln Gly 
545                 550                 555                 560 


Pro Ala Gly Pro Val Val Gln Ser Pro Asn Ser Gln Pro Val Pro Gly 
                565                 570                 575     


Ala Gln Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Lys Asp Gly Thr 
            580                 585                 590         


Pro Gly Arg Asp Gly Glu Pro Gly Asp Pro Gly Glu Asp Gly Arg Pro 
        595                 600                 605             


Gly Asp Thr Gly Pro Gln Gly Phe Pro Gly Thr Pro Gly Asp Val Gly 
    610                 615                 620                 


Pro Lys Gly Glu Lys Gly Asp Pro Gly Ile Gly Pro Arg Gly Pro Pro 
625                 630                 635                 640 


Gly Pro Pro Gly Pro Pro Gly Pro Ser Phe Arg Gln Asp Lys Leu Thr 
                645                 650                 655     


Phe Ile Asp Met Glu Gly Ser Gly Phe Ser Gly Asp Ile Glu Ser Leu 
            660                 665                 670         


Arg Gly Pro Arg Gly Phe Pro Gly Pro Pro Gly Pro Pro Gly Val Pro 
        675                 680                 685             


Gly Leu Pro Gly Glu Pro Gly Arg Phe Gly Ile Asn Gly Ser Tyr Ala 
    690                 695                 700                 


Pro Gly Pro Ala Gly Leu Pro Gly Val Pro Gly Lys Glu Gly Pro Pro 
705                 710                 715                 720 


Gly Phe Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Lys Glu Gly 
                725                 730                 735     


Pro Pro Gly Val Ala Gly Gln Lys Gly Ser Val Gly Asp Val Gly Ile 
            740                 745                 750         


Pro Gly Pro Lys Gly Ser Lys Gly Asp Leu Gly Pro Ile Gly Met Pro 
        755                 760                 765             


Gly Lys Ser Gly Leu Ala Gly Ser Pro Gly Pro Val Gly Pro Pro Gly 
    770                 775                 780                 


Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Gly Phe Ala Ala Gly Phe 
785                 790                 795                 800 


Asp Asp Met Glu Gly Ser Gly Ile Pro Leu Trp Thr Thr Ala Arg Ser 
                805                 810                 815     


Ser Asp Gly Leu Gln Gly Pro Pro Gly Ser Pro Gly Leu Lys Gly Asp 
            820                 825                 830         


Pro Gly Val Ala Gly Leu Pro Gly Ala Lys Gly Glu Val Gly Ala Asp 
        835                 840                 845             


Gly Ala Gln Gly Ile Pro Gly Pro Pro Gly Arg Glu Gly Ala Ala Gly 
    850                 855                 860                 


Ser Pro Gly Pro Lys Gly Glu Lys Gly Met Pro Gly Glu Lys Gly Asn 
865                 870                 875                 880 


Pro Gly Lys Asp Gly Val Gly Arg Pro Gly Leu Pro Gly Pro Pro Gly 
                885                 890                 895     


Pro Pro Gly Pro Val Ile Tyr Val Ser Ser Glu Asp Lys Ala Ile Val 
            900                 905                 910         


Ser Thr Pro Gly Pro Glu Gly Lys Pro Gly Tyr Ala Gly Phe Pro Gly 
        915                 920                 925             


Pro Ala Gly Pro Lys Gly Asp Leu Gly Ser Lys Gly Glu Gln Gly Leu 
    930                 935                 940                 


Pro Gly Pro Lys Gly Glu Lys Gly Glu Pro Gly Thr Ile Phe Ser Pro 
945                 950                 955                 960 


Asp Gly Arg Ala Leu Gly His Pro Gln Lys Gly Ala Lys Gly Glu Pro 
                965                 970                 975     


Gly Phe Arg Gly Pro Pro Gly Pro Tyr Gly Arg Pro Gly His Lys Gly 
            980                 985                 990         


Glu Ile Gly Phe Pro Gly Arg Pro  Gly Arg Pro Gly Thr  Asn Gly Leu 
        995                 1000                 1005             


Lys Gly  Glu Lys Gly Glu Pro  Gly Asp Ala Ser Leu  Gly Phe Ser 
    1010                 1015                 1020             


Met Arg  Gly Leu Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Pro Gly 
    1025                 1030                 1035             


Pro Pro  Gly Met Pro Ile Tyr  Asp Ser Asn Ala Phe  Val Glu Ser 
    1040                 1045                 1050             


Gly Arg  Pro Gly Leu Pro Gly  Gln Gln Gly Val Gln  Gly Pro Ser 
    1055                 1060                 1065             


Gly Pro  Lys Gly Asp Lys Gly  Glu Val Gly Pro Pro  Gly Pro Pro 
    1070                 1075                 1080             


Gly Gln  Phe Pro Ile Asp Leu  Phe His Leu Glu Ala  Glu Met Lys 
    1085                 1090                 1095             


Gly Asp  Lys Gly Asp Arg Gly  Asp Ala Gly Gln Lys  Gly Glu Arg 
    1100                 1105                 1110             


Gly Glu  Pro Gly Ala Pro Gly  Gly Gly Phe Phe Ser  Ser Ser Val 
    1115                 1120                 1125             


Pro Gly  Pro Pro Gly Pro Pro  Gly Tyr Pro Gly Ile  Pro Gly Pro 
    1130                 1135                 1140             


Lys Gly  Glu Ser Ile Arg Gly  Pro Pro Gly Pro Pro  Gly Pro Gln 
    1145                 1150                 1155             


Gly Pro  Pro Gly Ile Gly Tyr  Glu Gly Arg Gln Gly  Pro Pro Gly 
    1160                 1165                 1170             


Pro Pro  Gly Pro Pro Gly Pro  Pro Ser Phe Pro Gly  Pro His Arg 
    1175                 1180                 1185             


Gln Thr  Val Ser Val Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 
    1190                 1195                 1200             


Gly Pro  Pro Gly Ala Met Gly  Ala Ser Ala Gly Gln  Val Arg Ile 
    1205                 1210                 1215             


Trp Ala  Thr Tyr Gln Thr Met  Leu Asp Lys Ile Arg  Glu Val Pro 
    1220                 1225                 1230             


Glu Gly  Trp Leu Ile Phe Val  Ala Glu Arg Glu Glu  Leu Tyr Val 
    1235                 1240                 1245             


Arg Val  Arg Asn Gly Phe Arg  Lys Val Leu Leu Glu  Ala Arg Thr 
    1250                 1255                 1260             


Ala Leu  Pro Arg Gly Thr Gly  Asn Glu Val Ala Ala  Leu Gln Pro 
    1265                 1270                 1275             


Pro Leu  Val Gln Leu His Glu  Gly Ser Pro Tyr Thr  Arg Arg Glu 
    1280                 1285                 1290             


Tyr Ser  Tyr Ser Thr Ala Arg  Pro Trp Arg Ala Asp  Asp Ile Leu 
    1295                 1300                 1305             


Ala Asn  Pro Pro Arg Leu Pro  Asp Arg Gln Pro Tyr  Pro Gly Val 
    1310                 1315                 1320             


Pro His  His His Ser Ser Tyr  Val His Leu Pro Pro  Ala Arg Pro 
    1325                 1330                 1335             


Thr Leu  Ser Leu Ala His Thr  His Gln Asp Phe Gln  Pro Val Leu 
    1340                 1345                 1350             


His Leu  Val Ala Leu Asn Thr  Pro Leu Ser Gly Gly  Met Arg Gly 
    1355                 1360                 1365             


Ile Arg  Gly Ala Asp Phe Gln  Cys Phe Gln Gln Ala  Arg Ala Val 
    1370                 1375                 1380             


Gly Leu  Ser Gly Thr Phe Arg  Ala Phe Leu Ser Ser  Arg Leu Gln 
    1385                 1390                 1395             


Asp Leu  Tyr Ser Ile Val Arg  Arg Ala Asp Arg Gly  Ser Val Pro 
    1400                 1405                 1410             


Ile Val  Asn Leu Lys Asp Glu  Val Leu Ser Pro Ser  Trp Asp Ser 
    1415                 1420                 1425             


Leu Phe  Ser Gly Ser Gln Gly  Gln Leu Gln Pro Gly  Ala Arg Ile 
    1430                 1435                 1440             


Phe Ser  Phe Asp Gly Arg Asp  Val Leu Arg His Pro  Ala Trp Pro 
    1445                 1450                 1455             


Gln Lys  Ser Val Trp His Gly  Ser Asp Pro Ser Gly  Arg Arg Leu 
    1460                 1465                 1470             


Met Glu  Ser Tyr Cys Glu Thr  Trp Arg Thr Glu Thr  Thr Gly Ala 
    1475                 1480                 1485             


Thr Gly  Gln Ala Ser Ser Leu  Leu Ser Gly Arg Leu  Leu Glu Gln 
    1490                 1495                 1500             


Lys Ala  Ala Ser Cys His Asn  Ser Tyr Ile Val Leu  Cys Ile Glu 
    1505                 1510                 1515             


Asn Ser  Phe Met Thr Ser Phe  Ser Lys 
    1520                 1525         


<210>  2
<211>  1516
<212>  PRT
<213>  human

<400>  2

Met Ala Pro Tyr Pro Cys Gly Cys His Ile Leu Leu Leu Leu Phe Cys 
1               5                   10                  15      


Cys Leu Ala Ala Ala Arg Ala Asn Leu Leu Asn Leu Asn Trp Leu Trp 
            20                  25                  30          


Phe Asn Asn Glu Asp Thr Ser His Ala Ala Thr Thr Ile Pro Glu Pro 
        35                  40                  45              


Gln Gly Pro Leu Pro Val Gln Pro Thr Ala Asp Thr Thr Thr His Val 
    50                  55                  60                  


Thr Pro Arg Asn Gly Ser Thr Glu Pro Ala Thr Ala Pro Gly Ser Pro 
65                  70                  75                  80  


Glu Pro Pro Ser Glu Leu Leu Glu Asp Gly Gln Asp Thr Pro Thr Ser 
                85                  90                  95      


Ala Glu Ser Pro Asp Ala Pro Glu Glu Asn Ile Ala Gly Val Gly Ala 
            100                 105                 110         


Glu Ile Leu Asn Val Ala Lys Gly Ile Arg Ser Phe Val Gln Leu Trp 
        115                 120                 125             


Asn Asp Thr Val Pro Thr Glu Ser Leu Ala Arg Ala Glu Thr Leu Val 
    130                 135                 140                 


Leu Glu Thr Pro Val Gly Pro Leu Ala Leu Ala Gly Pro Ser Ser Thr 
145                 150                 155                 160 


Pro Gln Glu Asn Gly Thr Thr Leu Trp Pro Ser Arg Gly Ile Pro Ser 
                165                 170                 175     


Ser Pro Gly Ala His Thr Thr Glu Ala Gly Thr Leu Pro Ala Pro Thr 
            180                 185                 190         


Pro Ser Pro Pro Ser Leu Gly Arg Pro Trp Ala Pro Leu Thr Gly Pro 
        195                 200                 205             


Ser Val Pro Pro Pro Ser Ser Glu Arg Ile Ser Glu Glu Val Gly Leu 
    210                 215                 220                 


Leu Gln Leu Leu Gly Asp Pro Pro Pro Gln Gln Val Thr Gln Thr Asp 
225                 230                 235                 240 


Asp Pro Asp Val Gly Leu Ala Tyr Val Phe Gly Pro Asp Ala Asn Ser 
                245                 250                 255     


Gly Gln Val Ala Arg Tyr His Phe Pro Ser Leu Phe Phe Arg Asp Phe 
            260                 265                 270         


Ser Leu Leu Phe His Ile Arg Pro Ala Thr Glu Gly Pro Gly Val Leu 
        275                 280                 285             


Phe Ala Ile Thr Asp Ser Ala Gln Ala Met Val Leu Leu Gly Val Lys 
    290                 295                 300                 


Leu Ser Gly Val Gln Asp Gly His Gln Asp Ile Ser Leu Leu Tyr Thr 
305                 310                 315                 320 


Glu Pro Gly Ala Gly Gln Thr His Thr Ala Ala Ser Phe Arg Leu Pro 
                325                 330                 335     


Ala Phe Val Gly Gln Trp Thr His Leu Ala Leu Ser Val Ala Gly Gly 
            340                 345                 350         


Phe Val Ala Leu Tyr Val Asp Cys Glu Glu Phe Gln Arg Met Pro Leu 
        355                 360                 365             


Ala Arg Ser Ser Arg Gly Leu Glu Leu Glu Pro Gly Ala Gly Leu Phe 
    370                 375                 380                 


Val Ala Gln Ala Gly Gly Ala Asp Pro Asp Lys Phe Gln Gly Val Ile 
385                 390                 395                 400 


Ala Glu Leu Lys Val Arg Arg Asp Pro Gln Val Ser Pro Met His Cys 
                405                 410                 415     


Leu Asp Glu Glu Gly Asp Asp Ser Asp Gly Ala Ser Gly Asp Ser Gly 
            420                 425                 430         


Ser Gly Leu Gly Asp Ala Arg Glu Leu Leu Arg Glu Glu Thr Gly Ala 
        435                 440                 445             


Ala Leu Lys Pro Arg Leu Pro Ala Pro Pro Pro Val Thr Thr Pro Pro 
    450                 455                 460                 


Leu Ala Gly Gly Ser Ser Thr Glu Asp Ser Arg Ser Glu Glu Val Glu 
465                 470                 475                 480 


Glu Gln Thr Thr Val Ala Ser Leu Gly Ala Gln Thr Leu Pro Gly Ser 
                485                 490                 495     


Asp Ser Val Ser Thr Trp Asp Gly Ser Val Arg Thr Pro Gly Gly Arg 
            500                 505                 510         


Val Lys Glu Gly Gly Leu Lys Gly Gln Lys Gly Glu Pro Gly Val Pro 
        515                 520                 525             


Gly Pro Pro Gly Arg Ala Gly Pro Pro Gly Ser Pro Cys Leu Pro Gly 
    530                 535                 540                 


Pro Pro Gly Leu Pro Cys Pro Val Ser Pro Leu Gly Pro Ala Gly Pro 
545                 550                 555                 560 


Ala Leu Gln Thr Val Pro Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly 
                565                 570                 575     


Arg Asp Gly Thr Pro Gly Arg Asp Gly Glu Pro Gly Asp Pro Gly Glu 
            580                 585                 590         


Asp Gly Lys Pro Gly Asp Thr Gly Pro Gln Gly Phe Pro Gly Thr Pro 
        595                 600                 605             


Gly Asp Val Gly Pro Lys Gly Asp Lys Gly Asp Pro Gly Val Gly Glu 
    610                 615                 620                 


Arg Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly Pro Ser 
625                 630                 635                 640 


Phe Arg His Asp Lys Leu Thr Phe Ile Asp Met Glu Gly Ser Gly Phe 
                645                 650                 655     


Gly Gly Asp Leu Glu Ala Leu Arg Gly Pro Arg Gly Phe Pro Gly Pro 
            660                 665                 670         


Pro Gly Pro Pro Gly Val Pro Gly Leu Pro Gly Glu Pro Gly Arg Phe 
        675                 680                 685             


Gly Val Asn Ser Ser Asp Val Pro Gly Pro Ala Gly Leu Pro Gly Val 
    690                 695                 700                 


Pro Gly Arg Glu Gly Pro Pro Gly Phe Pro Gly Leu Pro Gly Pro Pro 
705                 710                 715                 720 


Gly Pro Pro Gly Arg Glu Gly Pro Pro Gly Arg Thr Gly Gln Lys Gly 
                725                 730                 735     


Ser Leu Gly Glu Ala Gly Ala Pro Gly His Lys Gly Ser Lys Gly Ala 
            740                 745                 750         


Pro Gly Pro Ala Gly Ala Arg Gly Glu Ser Gly Leu Ala Gly Ala Pro 
        755                 760                 765             


Gly Pro Ala Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
    770                 775                 780                 


Pro Gly Leu Pro Ala Gly Phe Asp Asp Met Glu Gly Ser Gly Gly Pro 
785                 790                 795                 800 


Phe Trp Ser Thr Ala Arg Ser Ala Asp Gly Pro Gln Gly Pro Pro Gly 
                805                 810                 815     


Leu Pro Gly Leu Lys Gly Asp Pro Gly Val Pro Gly Leu Pro Gly Ala 
            820                 825                 830         


Lys Gly Glu Val Gly Ala Asp Gly Val Pro Gly Phe Pro Gly Leu Pro 
        835                 840                 845             


Gly Arg Glu Gly Ile Ala Gly Pro Gln Gly Pro Lys Gly Asp Arg Gly 
    850                 855                 860                 


Ser Arg Gly Glu Lys Gly Asp Pro Gly Lys Asp Gly Val Gly Gln Pro 
865                 870                 875                 880 


Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Val Val Tyr Val Ser 
                885                 890                 895     


Glu Gln Asp Gly Ser Val Leu Ser Val Pro Gly Pro Glu Gly Arg Pro 
            900                 905                 910         


Gly Phe Ala Gly Phe Pro Gly Pro Ala Gly Pro Lys Gly Asn Leu Gly 
        915                 920                 925             


Ser Lys Gly Glu Arg Gly Ser Pro Gly Pro Lys Gly Glu Lys Gly Glu 
    930                 935                 940                 


Pro Gly Ser Ile Phe Ser Pro Asp Gly Gly Ala Leu Gly Pro Ala Gln 
945                 950                 955                 960 


Lys Gly Ala Lys Gly Glu Pro Gly Phe Arg Gly Pro Pro Gly Pro Tyr 
                965                 970                 975     


Gly Arg Pro Gly Tyr Lys Gly Glu Ile Gly Phe Pro Gly Arg Pro Gly 
            980                 985                 990         


Arg Pro Gly Met Asn Gly Leu Lys  Gly Glu Lys Gly Glu  Pro Gly Asp 
        995                 1000                 1005             


Ala Ser  Leu Gly Phe Gly Met  Arg Gly Met Pro Gly  Pro Pro Gly 
    1010                 1015                 1020             


Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Thr Pro Val  Tyr Asp Ser 
    1025                 1030                 1035             


Asn Val  Phe Ala Glu Ser Ser  Arg Pro Gly Pro Pro  Gly Leu Pro 
    1040                 1045                 1050             


Gly Asn  Gln Gly Pro Pro Gly  Pro Lys Gly Ala Lys  Gly Glu Val 
    1055                 1060                 1065             


Gly Pro  Pro Gly Pro Pro Gly  Gln Phe Pro Phe Asp  Phe Leu Gln 
    1070                 1075                 1080             


Leu Glu  Ala Glu Met Lys Gly  Glu Lys Gly Asp Arg  Gly Asp Ala 
    1085                 1090                 1095             


Gly Gln  Lys Gly Glu Arg Gly  Glu Pro Gly Gly Gly  Gly Phe Phe 
    1100                 1105                 1110             


Gly Ser  Ser Leu Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Arg Gly 
    1115                 1120                 1125             


Tyr Pro  Gly Ile Pro Gly Pro  Lys Gly Glu Ser Ile  Arg Gly Gln 
    1130                 1135                 1140             


Pro Gly  Pro Pro Gly Pro Gln  Gly Pro Pro Gly Ile  Gly Tyr Glu 
    1145                 1150                 1155             


Gly Arg  Gln Gly Pro Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 
    1160                 1165                 1170             


Ser Phe  Pro Gly Pro His Arg  Gln Thr Ile Ser Val  Pro Gly Pro 
    1175                 1180                 1185             


Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro Gly Thr  Met Gly Ala 
    1190                 1195                 1200             


Ser Ser  Gly Val Arg Leu Trp  Ala Thr Arg Gln Ala  Met Leu Gly 
    1205                 1210                 1215             


Gln Val  His Glu Val Pro Glu  Gly Trp Leu Ile Phe  Val Ala Glu 
    1220                 1225                 1230             


Gln Glu  Glu Leu Tyr Val Arg  Val Gln Asn Gly Phe  Arg Lys Val 
    1235                 1240                 1245             


Gln Leu  Glu Ala Arg Thr Pro  Leu Pro Arg Gly Thr  Asp Asn Glu 
    1250                 1255                 1260             


Val Ala  Ala Leu Gln Pro Pro  Val Val Gln Leu His  Asp Ser Asn 
    1265                 1270                 1275             


Pro Tyr  Pro Arg Arg Glu His  Pro His Pro Thr Ala  Arg Pro Trp 
    1280                 1285                 1290             


Arg Ala  Asp Asp Ile Leu Ala  Ser Pro Pro Arg Leu  Pro Glu Pro 
    1295                 1300                 1305             


Gln Pro  Tyr Pro Gly Ala Pro  His His Ser Ser Tyr  Val His Leu 
    1310                 1315                 1320             


Arg Pro  Ala Arg Pro Thr Ser  Pro Pro Ala His Ser  His Arg Asp 
    1325                 1330                 1335             


Phe Gln  Pro Val Leu His Leu  Val Ala Leu Asn Ser  Pro Leu Ser 
    1340                 1345                 1350             


Gly Gly  Met Arg Gly Ile Arg  Gly Ala Asp Phe Gln  Cys Phe Gln 
    1355                 1360                 1365             


Gln Ala  Arg Ala Val Gly Leu  Ala Gly Thr Phe Arg  Ala Phe Leu 
    1370                 1375                 1380             


Ser Ser  Arg Leu Gln Asp Leu  Tyr Ser Ile Val Arg  Arg Ala Asp 
    1385                 1390                 1395             


Arg Ala  Ala Val Pro Ile Val  Asn Leu Lys Asp Glu  Leu Leu Phe 
    1400                 1405                 1410             


Pro Ser  Trp Glu Ala Leu Phe  Ser Gly Ser Glu Gly  Pro Leu Lys 
    1415                 1420                 1425             


Pro Gly  Ala Arg Ile Phe Ser  Phe Asp Gly Lys Asp  Val Leu Arg 
    1430                 1435                 1440             


His Pro  Thr Trp Pro Gln Lys  Ser Val Trp His Gly  Ser Asp Pro 
    1445                 1450                 1455             


Asn Gly  Arg Arg Leu Thr Glu  Ser Tyr Cys Glu Thr  Trp Arg Thr 
    1460                 1465                 1470             


Glu Ala  Pro Ser Ala Thr Gly  Gln Ala Ser Ser Leu  Leu Gly Gly 
    1475                 1480                 1485             


Arg Leu  Leu Gly Gln Ser Ala  Ala Ser Cys His His  Ala Tyr Ile 
    1490                 1495                 1500             


Val Leu  Cys Ile Glu Asn Ser  Phe Met Thr Ala Ser  Lys 
    1505                 1510                 1515     


<210>  3
<211>  315
<212>  PRT
<213>  mouse

<400>  3

Ala Gly Gln Val Arg Ile Trp Ala Thr Tyr Gln Thr Met Leu Asp Lys 
1               5                   10                  15      


Ile Arg Glu Val Pro Glu Gly Trp Leu Ile Phe Val Ala Glu Arg Glu 
            20                  25                  30          


Glu Leu Tyr Val Arg Val Arg Asn Gly Phe Arg Lys Val Leu Leu Glu 
        35                  40                  45              


Ala Arg Thr Ala Leu Pro Arg Gly Thr Gly Asn Glu Val Ala Ala Leu 
    50                  55                  60                  


Gln Pro Pro Leu Val Gln Leu His Glu Gly Ser Pro Tyr Thr Arg Arg 
65                  70                  75                  80  


Glu Tyr Ser Tyr Ser Thr Ala Arg Pro Trp Arg Ala Asp Asp Ile Leu 
                85                  90                  95      


Ala Asn Pro Pro Arg Leu Pro Asp Arg Gln Pro Tyr Pro Gly Val Pro 
            100                 105                 110         


His His His Ser Ser Tyr Val His Leu Pro Pro Ala Arg Pro Thr Leu 
        115                 120                 125             


Ser Leu Ala His Thr His Gln Asp Phe Gln Pro Val Leu His Leu Val 
    130                 135                 140                 


Ala Leu Asn Thr Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala 
145                 150                 155                 160 


Asp Phe Gln Cys Phe Gln Gln Ala Arg Ala Val Gly Leu Ser Gly Thr 
                165                 170                 175     


Phe Arg Ala Phe Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val 
            180                 185                 190         


Arg Arg Ala Asp Arg Gly Ser Val Pro Ile Val Asn Leu Lys Asp Glu 
        195                 200                 205             


Val Leu Ser Pro Ser Trp Asp Ser Leu Phe Ser Gly Ser Gln Gly Gln 
    210                 215                 220                 


Leu Gln Pro Gly Ala Arg Ile Phe Ser Phe Asp Gly Arg Asp Val Leu 
225                 230                 235                 240 


Arg His Pro Ala Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro 
                245                 250                 255     


Ser Gly Arg Arg Leu Met Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu 
            260                 265                 270         


Thr Thr Gly Ala Thr Gly Gln Ala Ser Ser Leu Leu Ser Gly Arg Leu 
        275                 280                 285             


Leu Glu Gln Lys Ala Ala Ser Cys His Asn Ser Tyr Ile Val Leu Cys 
    290                 295                 300                 


Ile Glu Asn Ser Phe Met Thr Ser Phe Ser Lys 
305                 310                 315 


<210>  4
<211>  312
<212>  PRT
<213>  human

<400>  4

Ser Gly Val Arg Leu Trp Ala Thr Arg Gln Ala Met Leu Gly Gln Val 
1               5                   10                  15      


His Glu Val Pro Glu Gly Trp Leu Ile Phe Val Ala Glu Gln Glu Glu 
            20                  25                  30          


Leu Tyr Val Arg Val Gln Asn Gly Phe Arg Lys Val Gln Leu Glu Ala 
        35                  40                  45              


Arg Thr Pro Leu Pro Arg Gly Thr Asp Asn Glu Val Ala Ala Leu Gln 
    50                  55                  60                  


Pro Pro Val Val Gln Leu His Asp Ser Asn Pro Tyr Pro Arg Arg Glu 
65                  70                  75                  80  


His Pro His Pro Thr Ala Arg Pro Trp Arg Ala Asp Asp Ile Leu Ala 
                85                  90                  95      


Ser Pro Pro Arg Leu Pro Glu Pro Gln Pro Tyr Pro Gly Ala Pro His 
            100                 105                 110         


His Ser Ser Tyr Val His Leu Arg Pro Ala Arg Pro Thr Ser Pro Pro 
        115                 120                 125             


Ala His Ser His Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu 
    130                 135                 140                 


Asn Ser Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe 
145                 150                 155                 160 


Gln Cys Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg 
                165                 170                 175     


Ala Phe Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg 
            180                 185                 190         


Ala Asp Arg Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu 
        195                 200                 205             


Phe Pro Ser Trp Glu Ala Leu Phe Ser Gly Ser Glu Gly Pro Leu Lys 
    210                 215                 220                 


Pro Gly Ala Arg Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His 
225                 230                 235                 240 


Pro Thr Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly 
                245                 250                 255     


Arg Arg Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro 
            260                 265                 270         


Ser Ala Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly 
        275                 280                 285             


Gln Ser Ala Ala Ser Cys His His Ala Tyr Ile Val Leu Cys Ile Glu 
    290                 295                 300                 


Asn Ser Phe Met Thr Ala Ser Lys 
305                 310         


<210>  5
<211>  233
<212>  PRT
<213>  mouse

<400>  5

Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
1               5                   10                  15      


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            20                  25                  30          


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
    50                  55                  60                  


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
65                  70                  75                  80  


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
                85                  90                  95      


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
            100                 105                 110         


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
        115                 120                 125             


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
    130                 135                 140                 


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
145                 150                 155                 160 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
                165                 170                 175     


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
            180                 185                 190         


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
        195                 200                 205             


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
    210                 215                 220                 


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
225                 230             


<210>  6
<211>  232
<212>  PRT
<213>  human

<400>  6

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         



<210>  7
<211>  28
<212>  PRT
<213>  mouse

<400>  7

His Thr His Gln Asp Phe Gln Pro Val Leu His Leu Val Leu Tyr Ala 
1               5                   10                  15      


Val Thr Gly Arg Gly Asp Ser Pro Ala Ser Ser Lys 
            20                  25              


<210>  8
<211>  15
<212>  PRT
<213>  mouse

<400>  8

Leu Tyr Ala Val Thr Gly Arg Gly Asp Ser Pro Ala Ser Ser Lys 
1               5                   10                  15  


<210>  9
<211>  26
<212>  PRT
<213>  mouse

<400>  9

His Thr His Gln Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn 
1               5                   10                  15      


Thr Pro Leu Ser Gly Gly Met Arg Gly Ile 
            20                  25      


<210>  10
<211>  25
<212>  PRT
<213>  human

<400>  10

His Ser His Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn 
1               5                   10                  15      


Ser Pro Leu Ser Gly Gly Met Arg Gly 
            20                  25  


<210>  11
<211>  15
<212>  PRT
<213>  mouse

<400>  11

Leu Tyr Ala Val Thr Gly Arg Gly Asp Ser Pro Ala Ser Ser Lys 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  human

<400>  12

Val Tyr Ala Val Thr Gly Arg Gly Asp Ser Pro Ala Ser Ser Lys 
1               5                   10                  15  


<210>  13
<211>  27
<212>  PRT
<213>  human

<400>  13

His Ser His Arg Asp Phe Gln Pro Val Leu His Leu Val Tyr Ala Val 
1               5                   10                  15      


Thr Gly Arg Gly Asp Ser Pro Ala Ser Ser Lys 
            20                  25          


<210>  14
<211>  27
<212>  PRT
<213>  human

<400>  14

Ala Ser Ala Arg Asp Phe Gln Pro Val Leu His Leu Val Tyr Ala Val 
1               5                   10                  15      


Thr Gly Arg Gly Asp Ser Pro Ala Ser Ser Lys 
            20                  25          


<210>  15
<211>  27
<212>  PRT
<213>  human

<400>  15

His Ser His Arg Asp Phe Cys Pro Val Leu His Leu Val Tyr Ala Val 
1               5                   10                  15      


Thr Gly Arg Gly Asp Ser Pro Ala Ser Ser Lys 
            20                  25          


<210>  16
<211>  27
<212>  PRT
<213>  human

<400>  16

His Ser His Arg Asp Phe Gln Pro Val Leu His Leu Val Tyr Ala Val 
1               5                   10                  15      


Thr Gly Arg Ala Asp Ser Pro Ala Ser Ser Lys 
            20                  25          


<210>  17
<211>  25
<212>  PRT
<213>  mouse

<400>  17

Ile Lys Pro Gly Ala Asp Tyr Thr Ile Thr Leu Tyr Ala Val Thr Gly 
1               5                   10                  15      


Arg Gly Asp Ser Pro Ala Ser Ser Lys 
            20                  25  







