﻿               SEQUENCE LISTING

<110> Lead Discovery Center GmbH
      Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V
      .

<120> Susceptibility to selective CDK9 inhibitors

<130> T1305 PCT S3

<160> 12

<170> BiSSAP 1.0

<210> 1
<211> 3795
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..3795
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 1
gagttccgta ttctagttct gtgtgatctg atctttacct tcccttcctt ggatccctgt       60

gcacctactg gagccaggtt actctgggtc ctggacctga ctgcctcatt ctggaggctt      120

ccagacagcc acagttagtg cccaaacctg agaggatggc ttcagatgga gcatctgcat      180

tgccgggacc ggatatgagc atgaaaccta gtgccgccct gtctccatcc cctgcacttc      240

cctttctccc accaacttct gacccaccag accacccacc cagggagcca cctccacagc      300

ccatcatgcc ttcagtattc tctccagaca accctctgat gctctctgct ttccccagct      360

cactgttggt gacaggggac gggggccctt gcctcagtgg ggctggggct ggcaaggtca      420

ttgtcaaagt caagacagaa ggggggtcag ctgagccctc tcaaactcag aactttatcc      480

ttactcagac tgccctcaat tcgactgccc cgggcactcc ctgtggaggc cttgagggtc      540

ctgcacctcc atttgtgaca gcatctaatg tgaagaccat tctgccctct aaggctgttg      600

gtgtcagcca ggagggtcct ccaggccttc cgcctcagcc tccaccacca gttgctcaac      660

tggtccccat tgtgcccctg gaaaaagctt ggccagggcc acatgggaca accggggaag      720

gaggtcctgt ggccactcta tccaagcctt ccctaggtga ccgctccaaa atttccaagg      780

acgtttatga gaacttccgt cagtggcagc gttacaaagc cttggcccgg aggcacctat      840

cccagagtcc tgacacagaa gctctttcct gttttcttat cccagtgctt cgttccctgg      900

cccggctgaa gcccactatg accctggagg agggactgcc attggctgtg caggagtggg      960

agcacaccag caactttgac cggatgatct tttatgagat ggcagaaagg ttcatggagt     1020

ttgaggctga ggagatgcag attcagaaca cacagctgat gaatgggtct cagggcctgt     1080

ctcctgcaac ccctttgaaa cttgatcctc tagggcccct ggcctctgag gtttgccagc     1140

agccagtgta cattccgaag aaggcagcct ccaagacacg ggccccccgc cggcgtcagc     1200

gtaaagccca gagacctcct gctcctgagg cacccaagga gatcccacca gaagctgtga     1260

aggagtatgt tgacatcatg gaatggctgg tggggactca cttggccact ggggagtcag     1320

atggaaaaca agaggaagaa gggcagcagc aggaggagga agggatgtat ccagatccag     1380

gtctcctgag ctacatcaat gagctgtgtt ctcagaaggt ctttgtctcc aaggtggagg     1440

ctgtcattca ccctcaattt ctggcagatc tgctgtcccc agaaaaacag agagatccct     1500

tggccttaat tgaggagcta gagcaagaag aaggactcac tcttgcccag ctggtccaga     1560

agcgactcat ggccttggaa gaggaggaag atgcagaggc gcctccaagt ttcagtggcg     1620

ctcagttgga ctcaagtcct tctggttctg ttgaggatga agatggggat gggcggcttc     1680

ggccctcacc tgggcttcag ggggctgggg gcgccgcttg ccttggaaag gtttcttctt     1740

caggaaaacg ggcaagagaa gtgcatggtg ggcaggagca agccctagat agccccagag     1800

ggatgcacag ggatgggaac actctgccat cccccagcag ctgggacctg cagccagaac     1860

ttgcagctcc acagggaact ccgggaccct tgggtgtgga gaggagaggg tctgggaagg     1920

ttataaacca ggtatctcta catcaggatg gccatctagg aggcgctggg cctcctgggc     1980

actgcctggt ggctgatagg acttcagagg ctctgcccct ttgttggcag ggaggcttcc     2040

agcctgagag cactcccagt ttggatgctg gacttgcaga gctggctcct ctgcaaggac     2100

aagggttaga aaagcaagtc ctgggattgc agaaaggaca acaaacaggg ggtcgtggag     2160

tgcttcctca agggaaggag cctttagcag tgccctggga aggctcttca ggagccatgt     2220

ggggagatga cagaggtacc cccatggctc agagttatga tcagaatcct tcccctagag     2280

cagctgggga gagggacgat gtctgtctca gcccaggagt ttggctgagc agtgagatgg     2340

atgctgtagg cttggagctg cctgtacaaa tagaggaggt catagagagc ttccaagttg     2400

agaagtgtgt aactgagtat caggaaggct gccagggact gggctccagg ggcaacattt     2460

ccctgggtcc tggagaaacc ctagtacctg gggatacgga gagcagtgtg attccctgtg     2520

gaggcacagt tgcggcagct gccctagaaa agagaaacta ttgcagcttg ccaggacctt     2580

tgagggccaa cagcccaccc ttgaggtcca aagaaaatca agaacagagc tgtgaaaccg     2640

tagggcatcc cagtgatctg tgggcagaag gttgcttccc attgctagaa agtggtgatt     2700

ccacactggg gtcttccaaa gaaacccttc cacccacatg ccaaggcaat ctccttatca     2760

tggggactga ggatgcctcc tccttgcctg aagccagtca agaggcaggg agcagaggca     2820

attccttttc tcctctgttg gaaaccatag aacctgtcaa catactagat gttaaagatg     2880

actgtggcct ccaactaagg gtcagcgagg acacctgccc actgaatgtt cattcttatg     2940

acccccaagg agaaggcagg gtggatcctg atctgtccaa gcctaaaaac cttgctcctt     3000

tacaagagag tcaggagtct tacacaactg ggactcccaa agcaacatct tctcaccagg     3060

gccttggaag cactttgcct agaaggggaa ccaggaatgc catagttccg agagaaactt     3120

ctgttagtaa aacacacagg tcagcagaca gggccaaagg aaaggagaaa aagaaaaagg     3180

aagcagagga agaggatgag gaactctcca actttgctta cctcttggcc tctaaactta     3240

gcctctcacc aagggagcat cccctcagtc ctcaccatgc ctcaggaggt cagggcagcc     3300

agagagcatc ccacctgctc cctgctggag caaaaggccc cagcaaactt ccatatcctg     3360

ttgccaagtc tgggaagcga gctctagctg gaggtccagc ccctactgaa aagacacccc     3420

actcaggagc tcaacttggg gtccccaggg agaaacccct agctctggga gtagttcgac     3480

cctcacagcc tcgtaaaagg cggtgtgaca gttttgtcac gggcagaagg aagaaacgac     3540

gtcgtagcca gtagggagca gcgggaccat ctgaccccac ttgccagtcc ctaaaggtgg     3600

gtgccccaga gtagattcca cccctgctgc ccaccaatgg agaatcccaa tgttgaatct     3660

catcccaatg ttgttttgtt gttctgcaaa agtggcaagc atggagagag aggtcagact     3720

ggctaggctg cagggggaat tacctttgga aggagctata tagaaaaaaa atgaataaag     3780

tgttttgttg gaaaa                                                      3795


<210> 2
<211> 1132
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..1132
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 2
Met Ala Ser Asp Gly Ala Ser Ala Leu Pro Gly Pro Asp Met Ser Met 
1               5                   10                   15    
Lys Pro Ser Ala Ala Leu Ser Pro Ser Pro Ala Leu Pro Phe Leu Pro 
            20                   25                  30        
Pro Thr Ser Asp Pro Pro Asp His Pro Pro Arg Glu Pro Pro Pro Gln 
        35                   40                  45            
Pro Ile Met Pro Ser Val Phe Ser Pro Asp Asn Pro Leu Met Leu Ser 
    50                   55                  60                
Ala Phe Pro Ser Ser Leu Leu Val Thr Gly Asp Gly Gly Pro Cys Leu 
65                   70                  75                  80
Ser Gly Ala Gly Ala Gly Lys Val Ile Val Lys Val Lys Thr Glu Gly 
                85                   90                  95    
Gly Ser Ala Glu Pro Ser Gln Thr Gln Asn Phe Ile Leu Thr Gln Thr 
            100                  105                110        
Ala Leu Asn Ser Thr Ala Pro Gly Thr Pro Cys Gly Gly Leu Glu Gly 
        115                  120                125            
Pro Ala Pro Pro Phe Val Thr Ala Ser Asn Val Lys Thr Ile Leu Pro 
    130                  135                140                
Ser Lys Ala Val Gly Val Ser Gln Glu Gly Pro Pro Gly Leu Pro Pro 
145                  150                155                  160
Gln Pro Pro Pro Pro Val Ala Gln Leu Val Pro Ile Val Pro Leu Glu 
                165                  170                175    
Lys Ala Trp Pro Gly Pro His Gly Thr Thr Gly Glu Gly Gly Pro Val 
            180                  185                190        
Ala Thr Leu Ser Lys Pro Ser Leu Gly Asp Arg Ser Lys Ile Ser Lys 
        195                  200                205            
Asp Val Tyr Glu Asn Phe Arg Gln Trp Gln Arg Tyr Lys Ala Leu Ala 
    210                  215                220                
Arg Arg His Leu Ser Gln Ser Pro Asp Thr Glu Ala Leu Ser Cys Phe 
225                  230                235                  240
Leu Ile Pro Val Leu Arg Ser Leu Ala Arg Leu Lys Pro Thr Met Thr 
                245                  250                255    
Leu Glu Glu Gly Leu Pro Leu Ala Val Gln Glu Trp Glu His Thr Ser 
            260                  265                270        
Asn Phe Asp Arg Met Ile Phe Tyr Glu Met Ala Glu Arg Phe Met Glu 
        275                  280                285            
Phe Glu Ala Glu Glu Met Gln Ile Gln Asn Thr Gln Leu Met Asn Gly 
    290                  295                300                
Ser Gln Gly Leu Ser Pro Ala Thr Pro Leu Lys Leu Asp Pro Leu Gly 
305                  310                315                  320
Pro Leu Ala Ser Glu Val Cys Gln Gln Pro Val Tyr Ile Pro Lys Lys 
                325                  330                335    
Ala Ala Ser Lys Thr Arg Ala Pro Arg Arg Arg Gln Arg Lys Ala Gln 
            340                  345                350        
Arg Pro Pro Ala Pro Glu Ala Pro Lys Glu Ile Pro Pro Glu Ala Val 
        355                  360                365            
Lys Glu Tyr Val Asp Ile Met Glu Trp Leu Val Gly Thr His Leu Ala 
    370                  375                380                
Thr Gly Glu Ser Asp Gly Lys Gln Glu Glu Glu Gly Gln Gln Gln Glu 
385                  390                395                  400
Glu Glu Gly Met Tyr Pro Asp Pro Gly Leu Leu Ser Tyr Ile Asn Glu 
                405                  410                415    
Leu Cys Ser Gln Lys Val Phe Val Ser Lys Val Glu Ala Val Ile His 
            420                  425                430        
Pro Gln Phe Leu Ala Asp Leu Leu Ser Pro Glu Lys Gln Arg Asp Pro 
        435                  440                445            
Leu Ala Leu Ile Glu Glu Leu Glu Gln Glu Glu Gly Leu Thr Leu Ala 
    450                  455                460                
Gln Leu Val Gln Lys Arg Leu Met Ala Leu Glu Glu Glu Glu Asp Ala 
465                  470                475                  480
Glu Ala Pro Pro Ser Phe Ser Gly Ala Gln Leu Asp Ser Ser Pro Ser 
                485                  490                495    
Gly Ser Val Glu Asp Glu Asp Gly Asp Gly Arg Leu Arg Pro Ser Pro 
            500                  505                510        
Gly Leu Gln Gly Ala Gly Gly Ala Ala Cys Leu Gly Lys Val Ser Ser 
        515                  520                525            
Ser Gly Lys Arg Ala Arg Glu Val His Gly Gly Gln Glu Gln Ala Leu 
    530                  535                540                
Asp Ser Pro Arg Gly Met His Arg Asp Gly Asn Thr Leu Pro Ser Pro 
545                  550                555                  560
Ser Ser Trp Asp Leu Gln Pro Glu Leu Ala Ala Pro Gln Gly Thr Pro 
                565                  570                575    
Gly Pro Leu Gly Val Glu Arg Arg Gly Ser Gly Lys Val Ile Asn Gln 
            580                  585                590        
Val Ser Leu His Gln Asp Gly His Leu Gly Gly Ala Gly Pro Pro Gly 
        595                  600                605            
His Cys Leu Val Ala Asp Arg Thr Ser Glu Ala Leu Pro Leu Cys Trp 
    610                  615                620                
Gln Gly Gly Phe Gln Pro Glu Ser Thr Pro Ser Leu Asp Ala Gly Leu 
625                  630                635                  640
Ala Glu Leu Ala Pro Leu Gln Gly Gln Gly Leu Glu Lys Gln Val Leu 
                645                  650                655    
Gly Leu Gln Lys Gly Gln Gln Thr Gly Gly Arg Gly Val Leu Pro Gln 
            660                  665                670        
Gly Lys Glu Pro Leu Ala Val Pro Trp Glu Gly Ser Ser Gly Ala Met 
        675                  680                685            
Trp Gly Asp Asp Arg Gly Thr Pro Met Ala Gln Ser Tyr Asp Gln Asn 
    690                  695                700                
Pro Ser Pro Arg Ala Ala Gly Glu Arg Asp Asp Val Cys Leu Ser Pro 
705                  710                715                  720
Gly Val Trp Leu Ser Ser Glu Met Asp Ala Val Gly Leu Glu Leu Pro 
                725                  730                735    
Val Gln Ile Glu Glu Val Ile Glu Ser Phe Gln Val Glu Lys Cys Val 
            740                  745                750        
Thr Glu Tyr Gln Glu Gly Cys Gln Gly Leu Gly Ser Arg Gly Asn Ile 
        755                  760                765            
Ser Leu Gly Pro Gly Glu Thr Leu Val Pro Gly Asp Thr Glu Ser Ser 
    770                  775                780                
Val Ile Pro Cys Gly Gly Thr Val Ala Ala Ala Ala Leu Glu Lys Arg 
785                  790                795                  800
Asn Tyr Cys Ser Leu Pro Gly Pro Leu Arg Ala Asn Ser Pro Pro Leu 
                805                  810                815    
Arg Ser Lys Glu Asn Gln Glu Gln Ser Cys Glu Thr Val Gly His Pro 
            820                  825                830        
Ser Asp Leu Trp Ala Glu Gly Cys Phe Pro Leu Leu Glu Ser Gly Asp 
        835                  840                845            
Ser Thr Leu Gly Ser Ser Lys Glu Thr Leu Pro Pro Thr Cys Gln Gly 
    850                  855                860                
Asn Leu Leu Ile Met Gly Thr Glu Asp Ala Ser Ser Leu Pro Glu Ala 
865                  870                875                  880
Ser Gln Glu Ala Gly Ser Arg Gly Asn Ser Phe Ser Pro Leu Leu Glu 
                885                  890                895    
Thr Ile Glu Pro Val Asn Ile Leu Asp Val Lys Asp Asp Cys Gly Leu 
            900                  905                910        
Gln Leu Arg Val Ser Glu Asp Thr Cys Pro Leu Asn Val His Ser Tyr 
        915                  920                925            
Asp Pro Gln Gly Glu Gly Arg Val Asp Pro Asp Leu Ser Lys Pro Lys 
    930                  935                940                
Asn Leu Ala Pro Leu Gln Glu Ser Gln Glu Ser Tyr Thr Thr Gly Thr 
945                  950                955                  960
Pro Lys Ala Thr Ser Ser His Gln Gly Leu Gly Ser Thr Leu Pro Arg 
                965                  970                975    
Arg Gly Thr Arg Asn Ala Ile Val Pro Arg Glu Thr Ser Val Ser Lys 
            980                  985                990        
Thr His Arg Ser Ala Asp Arg Ala Lys Gly Lys Glu Lys Lys Lys Lys 
        995                  1000                1005            
Glu Ala Glu Glu Glu Asp Glu Glu Leu Ser Asn Phe Ala Tyr Leu Leu 
    1010                1015                1020                
Ala Ser Lys Leu Ser Leu Ser Pro Arg Glu His Pro Leu Ser Pro His 
1025                1030                1035                1040
His Ala Ser Gly Gly Gln Gly Ser Gln Arg Ala Ser His Leu Leu Pro 
                1045                1050                1055    
Ala Gly Ala Lys Gly Pro Ser Lys Leu Pro Tyr Pro Val Ala Lys Ser 
            1060                1065                1070        
Gly Lys Arg Ala Leu Ala Gly Gly Pro Ala Pro Thr Glu Lys Thr Pro 
        1075                1080                1085            
His Ser Gly Ala Gln Leu Gly Val Pro Arg Glu Lys Pro Leu Ala Leu 
    1090                1095                1100                
Gly Val Val Arg Pro Ser Gln Pro Arg Lys Arg Arg Cys Asp Ser Phe 
1105                1110                1115                1120
Val Thr Gly Arg Arg Lys Lys Arg Arg Arg Ser Gln 
                1125                1130        

<210> 3
<211> 5198
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..5198
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 3
attctttgga atactactgc tagaagtctg acttaagacc cagcttatgg gccacatggc       60

acccagctgc ttctgcagag aaggcaggcc actgatgggt acagcaaagt gtggtgctgc      120

tggccaagcc aaagacccgt gtaggatgac tgggcctctg ccccttgtgg gtgttgccac      180

tgtgcttgag tgcctggtga agaatgtgat gggatcacta gcatgtctgc ggagagcggc      240

cctgggacga gattgagaaa tctgccagta atgggggatg gactagaaac ttcccaaatg      300

tctacaacac aggcccaggc ccaaccccag ccagccaacg cagccagcac caaccccccg      360

cccccagaga cctccaaccc taacaagccc aagaggcaga ccaaccaact gcaatacctg      420

ctcagagtgg tgctcaagac actatggaaa caccagtttg catggccttt ccagcagcct      480

gtggatgccg tcaagctgaa cctccctgat tactataaga tcattaaaac gcctatggat      540

atgggaacaa taaagaagcg cttggaaaac aactattact ggaatgctca ggaatgtatc      600

caggacttca acactatgtt tacaaattgt tacatctaca acaagcctgg agatgacata      660

gtcttaatgg cagaagctct ggaaaagctc ttcttgcaaa aaataaatga gctacccaca      720

gaagaaaccg agatcatgat agtccaggca aaaggaagag gacgtgggag gaaagaaaca      780

gggacagcaa aacctggcgt ttccacggta ccaaacacaa ctcaagcatc gactcctccg      840

cagacccaga cccctcagcc gaatcctcct cctgtgcagg ccacgcctca ccccttccct      900

gccgtcaccc cggacctcat cgtccagacc cctgtcatga cagtggtgcc tccccagcca      960

ctgcagacgc ccccgccagt gcccccccag ccacaacccc cacccgctcc agctccccag     1020

cccgtacaga gccacccacc catcatcgcg gccaccccac agcctgtgaa gacaaagaag     1080

ggagtgaaga ggaaagcaga caccaccacc cccaccacca ttgaccccat tcacgagcca     1140

ccctcgctgc ccccggagcc caagaccacc aagctgggcc agcggcggga gagcagccgg     1200

cctgtgaaac ctccaaagaa ggacgtgccc gactctcagc agcacccagc accagagaag     1260

agcagcaagg tctcggagca gctcaagtgc tgcagcggca tcctcaagga gatgtttgcc     1320

aagaagcacg ccgcctacgc ctggcccttc tacaagcctg tggacgtgga ggcactgggc     1380

ctacacgact actgtgacat catcaagcac cccatggaca tgagcacaat caagtctaaa     1440

ctggaggccc gtgagtaccg tgatgctcag gagtttggtg ctgacgtccg attgatgttc     1500

tccaactgct ataagtacaa ccctcctgac catgaggtgg tggccatggc ccgcaagctc     1560

caggatgtgt tcgaaatgcg ctttgccaag atgccggacg agcctgagga gccagtggtg     1620

gccgtgtcct ccccggcagt gccccctccc accaaggttg tggccccgcc ctcatccagc     1680

gacagcagca gcgatagctc ctcggacagt gacagttcga ctgatgactc tgaggaggag     1740

cgagcccagc ggctggctga gctccaggag cagctcaaag ccgtgcacga gcagcttgca     1800

gccctctctc agccccagca gaacaaacca aagaaaaagg agaaagacaa gaaggaaaag     1860

aaaaaagaaa agcacaaaag gaaagaggaa gtggaagaga ataaaaaaag caaagccaag     1920

gaacctcctc ctaaaaagac gaagaaaaat aatagcagca acagcaatgt gagcaagaag     1980

gagccagcgc ccatgaagag caagccccct cccacgtatg agtcggagga agaggacaag     2040

tgcaagccta tgtcctatga ggagaagcgg cagctcagct tggacatcaa caagctcccc     2100

ggcgagaagc tgggccgcgt ggtgcacatc atccagtcac gggagccctc cctgaagaat     2160

tccaaccccg acgagattga aatcgacttt gagaccctga agccgtccac actgcgtgag     2220

ctggagcgct atgtcacctc ctgtttgcgg aagaaaagga aacctcaagc tgagaaagtt     2280

gatgtgattg ccggctcctc caagatgaag ggcttctcgt cctcagagtc ggagagctcc     2340

agtgagtcca gctcctctga cagcgaagac tccgaaacag agatggctcc gaagtcaaaa     2400

aagaaggggc accccgggag ggagcagaag aagcaccatc atcaccacca tcagcagatg     2460

cagcaggccc cggctcctgt gccccagcag ccgcccccgc ctccccagca gcccccaccg     2520

cctccacctc cgcagcagca acagcagccg ccacccccgc ctcccccacc ctccatgccg     2580

cagcaggcag ccccggcgat gaagtcctcg cccccaccct tcattgccac ccaggtgccc     2640

gtcctggagc cccagctccc aggcagcgtc tttgacccca tcggccactt cacccagccc     2700

atcctgcacc tgccgcagcc tgagctgccc cctcacctgc cccagccgcc tgagcacagc     2760

actccacccc atctcaacca gcacgcagtg gtctctcctc cagctttgca caacgcacta     2820

ccccagcagc catcacggcc cagcaaccga gccgctgccc tgcctcccaa gcccgcccgg     2880

cccccagccg tgtcaccagc cttgacccaa acacccctgc tcccacagcc ccccatggcc     2940

caaccccccc aagtgctgct ggaggatgaa gagccacctg ccccacccct cacctccatg     3000

cagatgcagc tgtacctgca gcagctgcag aaggtgcagc cccctacgcc gctactccct     3060

tccgtgaagg tgcagtccca gcccccaccc cccctgccgc ccccacccca cccctctgtg     3120

cagcagcagc tgcagcagca gccgccacca cccccaccac cccagcccca gcctccaccc     3180

cagcagcagc atcagccccc tccacggccc gtgcacttgc agcccatgca gttttccacc     3240

cacatccaac agcccccgcc accccagggc cagcagcccc cccatccgcc cccaggccag     3300

cagccacccc cgccgcagcc tgccaagcct cagcaagtca tccagcacca ccattcaccc     3360

cggcaccaca agtcggaccc ctactcaacc ggtcacctcc gcgaagcccc ctccccgctt     3420

atgatacatt ccccccagat gtcacagttc cagagcctga cccaccagtc tccaccccag     3480

caaaacgtcc agcctaagaa acaggagctg cgtgctgcct ccgtggtcca gccccagccc     3540

ctcgtggtgg tgaaggagga gaagatccac tcacccatca tccgcagcga gcccttcagc     3600

ccctcgctgc ggccggagcc ccccaagcac ccggagagca tcaaggcccc cgtccacctg     3660

ccccagcggc cggaaatgaa gcctgtggat gtcgggaggc ctgtgatccg gcccccagag     3720

cagaacgcac cgccaccagg ggcccctgac aaggacaaac agaaacagga gccgaagact     3780

ccagttgcgc ccaaaaagga cctgaaaatc aagaacatgg gctcctgggc cagcctagtg     3840

cagaagcatc cgaccacccc ctcctccaca gccaagtcat ccagcgacag cttcgagcag     3900

ttccgccgcg ccgctcggga gaaagaggag cgtgagaagg ccctgaaggc tcaggccgag     3960

cacgctgaga aggagaagga gcggctgcgg caggagcgca tgaggagccg agaggacgag     4020

gatgcgctgg agcaggcccg gcgggcccat gaggaggcac gtcggcgcca ggagcagcag     4080

cagcagcagc gccaggagca acagcagcag cagcaacagc aagcagctgc ggtggctgcc     4140

gccgccaccc cacaggccca gagctcccag ccccagtcca tgctggacca gcagagggag     4200

ttggcccgga agcgggagca ggagcgaaga cgccgggaag ccatggcagc taccattgac     4260

atgaatttcc agagtgatct attgtcaata tttgaagaaa atcttttctg agcgcaccta     4320

ggtggcttct gactttgatt ttctggcaaa acattgactt tccatagtgt taggggcggt     4380

ggtggaggtg ggatcagcgg ccaggggatg cctcagggcc tggccctcct gcatgctatg     4440

cccggggcag gcctgacggg cagctgagga ttgcagagcc tgtctgcctt acggccagtc     4500

ggacagacgt cccgccaccc accacccctc acaggacgtc cgctcagcac acgccttgtt     4560

acgagcaagt gccggctgga cccaagccct gcatccccac atgcggggca gaggcccttc     4620

tctccgccaa atgtctacac agtatacaca ggacatcgtt gctgccgccg tgactggttt     4680

tctgtcccca agaacgtgac gttcgtgatg tcctgcccgc cgggagtctt tccccacacc     4740

ccagccatcg ccgcccgctc ccaggaggcc agggcaggcc tgcgtgggct ggaggcgggc     4800

gaggccggcc caccccctcg ctggcactga ctttgccttg aacagacccc ccgaccctcc     4860

cccacaagcc tttaattgag agccgctctc tgtaagtgtt tgcttgtgca aaagggaata     4920

gtgccgtgga ggtgtgtgtg tccatggcat ccggagcgag gcgactgtcc tgcgtgggta     4980

gccctcggcc ggggagtgag gccaccaacc aaagtcagtt ccttcccacc tgtgtttctg     5040

tttcgttttt ttttttcttt tttttctata tatatttttt gttgaattct attttatttt     5100

taattctctc ttctcctcca gacacaatgg cactgcttat ctccgaaatg gtgtgatcgt     5160

ctcctcattg agcagcggct gccaccgcgc tgtgggta                             5198


<210> 4
<211> 1362
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..1362
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 4
Met Ser Ala Glu Ser Gly Pro Gly Thr Arg Leu Arg Asn Leu Pro Val 
1               5                   10                   15    
Met Gly Asp Gly Leu Glu Thr Ser Gln Met Ser Thr Thr Gln Ala Gln 
            20                   25                  30        
Ala Gln Pro Gln Pro Ala Asn Ala Ala Ser Thr Asn Pro Pro Pro Pro 
        35                   40                  45            
Glu Thr Ser Asn Pro Asn Lys Pro Lys Arg Gln Thr Asn Gln Leu Gln 
    50                   55                  60                
Tyr Leu Leu Arg Val Val Leu Lys Thr Leu Trp Lys His Gln Phe Ala 
65                   70                  75                  80
Trp Pro Phe Gln Gln Pro Val Asp Ala Val Lys Leu Asn Leu Pro Asp 
                85                   90                  95    
Tyr Tyr Lys Ile Ile Lys Thr Pro Met Asp Met Gly Thr Ile Lys Lys 
            100                  105                110        
Arg Leu Glu Asn Asn Tyr Tyr Trp Asn Ala Gln Glu Cys Ile Gln Asp 
        115                  120                125            
Phe Asn Thr Met Phe Thr Asn Cys Tyr Ile Tyr Asn Lys Pro Gly Asp 
    130                  135                140                
Asp Ile Val Leu Met Ala Glu Ala Leu Glu Lys Leu Phe Leu Gln Lys 
145                  150                155                  160
Ile Asn Glu Leu Pro Thr Glu Glu Thr Glu Ile Met Ile Val Gln Ala 
                165                  170                175    
Lys Gly Arg Gly Arg Gly Arg Lys Glu Thr Gly Thr Ala Lys Pro Gly 
            180                  185                190        
Val Ser Thr Val Pro Asn Thr Thr Gln Ala Ser Thr Pro Pro Gln Thr 
        195                  200                205            
Gln Thr Pro Gln Pro Asn Pro Pro Pro Val Gln Ala Thr Pro His Pro 
    210                  215                220                
Phe Pro Ala Val Thr Pro Asp Leu Ile Val Gln Thr Pro Val Met Thr 
225                  230                235                  240
Val Val Pro Pro Gln Pro Leu Gln Thr Pro Pro Pro Val Pro Pro Gln 
                245                  250                255    
Pro Gln Pro Pro Pro Ala Pro Ala Pro Gln Pro Val Gln Ser His Pro 
            260                  265                270        
Pro Ile Ile Ala Ala Thr Pro Gln Pro Val Lys Thr Lys Lys Gly Val 
        275                  280                285            
Lys Arg Lys Ala Asp Thr Thr Thr Pro Thr Thr Ile Asp Pro Ile His 
    290                  295                300                
Glu Pro Pro Ser Leu Pro Pro Glu Pro Lys Thr Thr Lys Leu Gly Gln 
305                  310                315                  320
Arg Arg Glu Ser Ser Arg Pro Val Lys Pro Pro Lys Lys Asp Val Pro 
                325                  330                335    
Asp Ser Gln Gln His Pro Ala Pro Glu Lys Ser Ser Lys Val Ser Glu 
            340                  345                350        
Gln Leu Lys Cys Cys Ser Gly Ile Leu Lys Glu Met Phe Ala Lys Lys 
        355                  360                365            
His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro Val Asp Val Glu Ala 
    370                  375                380                
Leu Gly Leu His Asp Tyr Cys Asp Ile Ile Lys His Pro Met Asp Met 
385                  390                395                  400
Ser Thr Ile Lys Ser Lys Leu Glu Ala Arg Glu Tyr Arg Asp Ala Gln 
                405                  410                415    
Glu Phe Gly Ala Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys Tyr 
            420                  425                430        
Asn Pro Pro Asp His Glu Val Val Ala Met Ala Arg Lys Leu Gln Asp 
        435                  440                445            
Val Phe Glu Met Arg Phe Ala Lys Met Pro Asp Glu Pro Glu Glu Pro 
    450                  455                460                
Val Val Ala Val Ser Ser Pro Ala Val Pro Pro Pro Thr Lys Val Val 
465                  470                475                  480
Ala Pro Pro Ser Ser Ser Asp Ser Ser Ser Asp Ser Ser Ser Asp Ser 
                485                  490                495    
Asp Ser Ser Thr Asp Asp Ser Glu Glu Glu Arg Ala Gln Arg Leu Ala 
            500                  505                510        
Glu Leu Gln Glu Gln Leu Lys Ala Val His Glu Gln Leu Ala Ala Leu 
        515                  520                525            
Ser Gln Pro Gln Gln Asn Lys Pro Lys Lys Lys Glu Lys Asp Lys Lys 
    530                  535                540                
Glu Lys Lys Lys Glu Lys His Lys Arg Lys Glu Glu Val Glu Glu Asn 
545                  550                555                  560
Lys Lys Ser Lys Ala Lys Glu Pro Pro Pro Lys Lys Thr Lys Lys Asn 
                565                  570                575    
Asn Ser Ser Asn Ser Asn Val Ser Lys Lys Glu Pro Ala Pro Met Lys 
            580                  585                590        
Ser Lys Pro Pro Pro Thr Tyr Glu Ser Glu Glu Glu Asp Lys Cys Lys 
        595                  600                605            
Pro Met Ser Tyr Glu Glu Lys Arg Gln Leu Ser Leu Asp Ile Asn Lys 
    610                  615                620                
Leu Pro Gly Glu Lys Leu Gly Arg Val Val His Ile Ile Gln Ser Arg 
625                  630                635                  640
Glu Pro Ser Leu Lys Asn Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe 
                645                  650                655    
Glu Thr Leu Lys Pro Ser Thr Leu Arg Glu Leu Glu Arg Tyr Val Thr 
            660                  665                670        
Ser Cys Leu Arg Lys Lys Arg Lys Pro Gln Ala Glu Lys Val Asp Val 
        675                  680                685            
Ile Ala Gly Ser Ser Lys Met Lys Gly Phe Ser Ser Ser Glu Ser Glu 
    690                  695                700                
Ser Ser Ser Glu Ser Ser Ser Ser Asp Ser Glu Asp Ser Glu Thr Glu 
705                  710                715                  720
Met Ala Pro Lys Ser Lys Lys Lys Gly His Pro Gly Arg Glu Gln Lys 
                725                  730                735    
Lys His His His His His His Gln Gln Met Gln Gln Ala Pro Ala Pro 
            740                  745                750        
Val Pro Gln Gln Pro Pro Pro Pro Pro Gln Gln Pro Pro Pro Pro Pro 
        755                  760                765            
Pro Pro Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Ser 
    770                  775                780                
Met Pro Gln Gln Ala Ala Pro Ala Met Lys Ser Ser Pro Pro Pro Phe 
785                  790                795                  800
Ile Ala Thr Gln Val Pro Val Leu Glu Pro Gln Leu Pro Gly Ser Val 
                805                  810                815    
Phe Asp Pro Ile Gly His Phe Thr Gln Pro Ile Leu His Leu Pro Gln 
            820                  825                830        
Pro Glu Leu Pro Pro His Leu Pro Gln Pro Pro Glu His Ser Thr Pro 
        835                  840                845            
Pro His Leu Asn Gln His Ala Val Val Ser Pro Pro Ala Leu His Asn 
    850                  855                860                
Ala Leu Pro Gln Gln Pro Ser Arg Pro Ser Asn Arg Ala Ala Ala Leu 
865                  870                875                  880
Pro Pro Lys Pro Ala Arg Pro Pro Ala Val Ser Pro Ala Leu Thr Gln 
                885                  890                895    
Thr Pro Leu Leu Pro Gln Pro Pro Met Ala Gln Pro Pro Gln Val Leu 
            900                  905                910        
Leu Glu Asp Glu Glu Pro Pro Ala Pro Pro Leu Thr Ser Met Gln Met 
        915                  920                925            
Gln Leu Tyr Leu Gln Gln Leu Gln Lys Val Gln Pro Pro Thr Pro Leu 
    930                  935                940                
Leu Pro Ser Val Lys Val Gln Ser Gln Pro Pro Pro Pro Leu Pro Pro 
945                  950                955                  960
Pro Pro His Pro Ser Val Gln Gln Gln Leu Gln Gln Gln Pro Pro Pro 
                965                  970                975    
Pro Pro Pro Pro Gln Pro Gln Pro Pro Pro Gln Gln Gln His Gln Pro 
            980                  985                990        
Pro Pro Arg Pro Val His Leu Gln Pro Met Gln Phe Ser Thr His Ile 
        995                  1000                1005            
Gln Gln Pro Pro Pro Pro Gln Gly Gln Gln Pro Pro His Pro Pro Pro 
    1010                1015                1020                
Gly Gln Gln Pro Pro Pro Pro Gln Pro Ala Lys Pro Gln Gln Val Ile 
1025                1030                1035                1040
Gln His His His Ser Pro Arg His His Lys Ser Asp Pro Tyr Ser Thr 
                1045                1050                1055    
Gly His Leu Arg Glu Ala Pro Ser Pro Leu Met Ile His Ser Pro Gln 
            1060                1065                1070        
Met Ser Gln Phe Gln Ser Leu Thr His Gln Ser Pro Pro Gln Gln Asn 
        1075                1080                1085            
Val Gln Pro Lys Lys Gln Glu Leu Arg Ala Ala Ser Val Val Gln Pro 
    1090                1095                1100                
Gln Pro Leu Val Val Val Lys Glu Glu Lys Ile His Ser Pro Ile Ile 
1105                1110                1115                1120
Arg Ser Glu Pro Phe Ser Pro Ser Leu Arg Pro Glu Pro Pro Lys His 
                1125                1130                1135    
Pro Glu Ser Ile Lys Ala Pro Val His Leu Pro Gln Arg Pro Glu Met 
            1140                1145                1150        
Lys Pro Val Asp Val Gly Arg Pro Val Ile Arg Pro Pro Glu Gln Asn 
        1155                1160                1165            
Ala Pro Pro Pro Gly Ala Pro Asp Lys Asp Lys Gln Lys Gln Glu Pro 
    1170                1175                1180                
Lys Thr Pro Val Ala Pro Lys Lys Asp Leu Lys Ile Lys Asn Met Gly 
1185                1190                1195                1200
Ser Trp Ala Ser Leu Val Gln Lys His Pro Thr Thr Pro Ser Ser Thr 
                1205                1210                1215    
Ala Lys Ser Ser Ser Asp Ser Phe Glu Gln Phe Arg Arg Ala Ala Arg 
            1220                1225                1230        
Glu Lys Glu Glu Arg Glu Lys Ala Leu Lys Ala Gln Ala Glu His Ala 
        1235                1240                1245            
Glu Lys Glu Lys Glu Arg Leu Arg Gln Glu Arg Met Arg Ser Arg Glu 
    1250                1255                1260                
Asp Glu Asp Ala Leu Glu Gln Ala Arg Arg Ala His Glu Glu Ala Arg 
1265                1270                1275                1280
Arg Arg Gln Glu Gln Gln Gln Gln Gln Arg Gln Glu Gln Gln Gln Gln 
                1285                1290                1295    
Gln Gln Gln Gln Ala Ala Ala Val Ala Ala Ala Ala Thr Pro Gln Ala 
            1300                1305                1310        
Gln Ser Ser Gln Pro Gln Ser Met Leu Asp Gln Gln Arg Glu Leu Ala 
        1315                1320                1325            
Arg Lys Arg Glu Gln Glu Arg Arg Arg Arg Glu Ala Met Ala Ala Thr 
    1330                1335                1340                
Ile Asp Met Asn Phe Gln Ser Asp Leu Leu Ser Ile Phe Glu Glu Asn 
1345                1350                1355                1360
Leu Phe 
        

<210> 5
<211> 5673
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..5673
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 5
tgccggggcc ggcgagccaa agaggagccg gccgcgcggg ccgggagggg acggccgccg       60

gagccgcgag gccaactgtc gcctggttgg gcccggaaat gggacgtcgc gctttctcag      120

ggagcgtaga agcagccagg gcctctccaa gccgctgctg tgacagaaag tgagtgagct      180

gccggaggat gtccaccgcc acgacagtcg cccccgcggg gatcccggcg accccgggcc      240

ctgtgaaccc accccccccg gaggtctcca accccagcaa gcccggccgc aagaccaacc      300

agctgcagta catgcagaat gtggtggtga agacgctctg gaaacaccag ttcgcctggc      360

ccttctacca gcccgtggac gcaatcaaat tgaacctgcc ggattatcat aaaataatta      420

aaaacccaat ggatatgggg actattaaga agagactaga aaataattat tattggagtg      480

caagcgaatg tatgcaggac ttcaacacca tgtttacaaa ttgttacatt tataacaagc      540

ccacagatga catagtgcta atggcccaag ctttagagaa aatttttcta caaaaagtgg      600

cccagatgcc ccaagaggaa gttgaattat taccccctgc tccaaagggc aaaggtcgga      660

agccggctgc gggagcccag agcgcaggta cacagcaagt ggcggccgtg tcctctgtct      720

ccccagcgac cccctttcag agcgtgcccc ccaccgtctc ccagacgccc gtcatcgctg      780

ccacccctgt accaaccatc actgcaaacg tcacgtcggt cccagtcccc ccagctgccg      840

ccccacctcc tcctgccaca cccatcgtcc ccgtggtccc tcctacgccg cctgtcgtca      900

agaaaaaggg cgtgaagcgg aaagcagaca caaccactcc cacgacgtcg gccatcactg      960

ccagccggag tgagtcgccc ccgccgttgt cagaccccaa gcaggccaaa gtggtggccc     1020

ggcgggagag tggtggccgc cccatcaagc ctcccaagaa ggacctggag gacggcgagg     1080

tgccccagca cgcaggcaag aagggcaagc tgtcggagca cctacgctac tgcgacagca     1140

tcctcaggga gatgctatcc aagaagcacg cggcctacgc ctggcccttc tacaagccag     1200

tggatgccga ggccctggag ctgcacgact accacgacat catcaagcac ccgatggacc     1260

tcagcaccgt gaaaaggaag atggatggcc gagagtaccc agacgcacag ggctttgctg     1320

ctgatgtccg gctgatgttc tcgaattgct acaaatacaa tcccccagac cacgaggttg     1380

tggccatggc ccggaagctc caggacgtgt ttgagatgag gtttgccaag atgccagatg     1440

agcccgtgga ggcaccggcg ctgcctgccc ccgcggcccc catggtgagc aagggcgctg     1500

agagcagccg tagcagtgag gagagctctt cggactcagg cagctcggac tcggaggagg     1560

agcgggccac caggctggcg gagctgcagg agcagctgaa ggccgtgcac gagcagctgg     1620

ccgccctgtc tcaggcccca gtaaacaaac caaagaagaa gaaggagaag aaggagaagg     1680

agaagaagaa gaaggacaag gagaaggaga aggagaagca caaagtgaag gccgaggaag     1740

agaagaaggc caaggtggct ccgcctgcca agcaggctca gcagaagaag gctcctgcca     1800

agaaggccaa cagcacgacc acggccggca gacagctgaa gaaaggcggc aagcaggcat     1860

ctgcctccta cgactcagag gaagaggagg agggcctgcc catgagctac gatgaaaagc     1920

gccagcttag cctggacatc aaccggctgc ccggggagaa gctgggccgg gtagtgcaca     1980

tcatccaatc tcgggagccc tcgctcaggg actccaaccc cgacgagata gaaattgact     2040

ttgagactct gaaacccacc actttgcggg aactggagag atatgtcaag tcttgtttac     2100

agaaaaagca aaggaaaccg ttctcagcaa gcgggaagaa acaggcagcc aagtcgaaag     2160

aggagctagc tcaggaaaag aagaaggagc tggaaaagcg tctgcaggat gtcagcgggc     2220

agctgagcag cagcaagaag cccgcccgga aagagaagcc cggctcagca ccctcagggg     2280

gcccgtccag gctcagcagc agcagctcct ccgagtctgg gagcagcagc tccagcgggt     2340

ccagctctga cagcagtgac tcagaatgaa ctggcttcgg acagaacagg acagatggat     2400

gtcgcacacg ccgagactct gccgtacccc tctgtggttc atattactac ttctgttcca     2460

tggtgtgcag gtctgcttct taattcagtg ttatgatatc ttccagtttt tgctttcata     2520

ggtcagagat ctatcttgtg tgtgcgttag acttgatgag aaggtgtgaa ctctgcagaa     2580

agtctcttct tcatcactga attcagtcac ttggagatga caacttcaaa tgctaacccg     2640

atgaccccag aaaaccgtgt gagattcgta ccgaagaacc ttgtggaatc cctttgctta     2700

ggcccaacct ggtcgatagc tcgagaaaga attttttcca aggaaatgtc tcggatatgg     2760

gtactgtatt tgaaagctgt tagctttgtc aacacgcatt gtccttgtca tttgggcccc     2820

gagctctgac cctcgtgtct gacgcggcca cctctttctg gaggggctga ggacagatgt     2880

gcctgcttgt ggagaccagg ctgggcctaa gcgaagggtc atcgcagccc cagcccggag     2940

cgtggagccc ttggggggtg gtcgggtggg atgtgcgttc tccgctcgtg gtgatgtcag     3000

gagctcctcg gagggaacag agcggctgtg tatgcagcct gcaggtttcc atacactgaa     3060

gcttttacct caactttaaa aaaaaaaaaa gaagaaaaga tttaaaaaaa aaaaaaaagg     3120

agactttttt tgtaaggttc ggcaattttc tacggaagtc cagcccgctg tgagtccccg     3180

cctggctagc gctgcccctg ctgctgctgc cgcgccaccc ttgggaacca cttcccgagc     3240

ttatgtgtat ataaatagtt atttattaac atcattggtc atttttaaaa aaaagaaaat     3300

aagaaaaaac cgcagaagaa atgcattcac acagtcgcag agatgcaggc cttgccagtg     3360

gtgtgccggg cgcgggtcct gtctggcggc ggcctgtcgt ctccaggtgc taactcctgc     3420

caccgcgcgg tgctcaccca cgtctgttcg cgcgctcgcc cctgggtttg ttgggttttt     3480

tggttttttt ctttgtggtt tttttttttt tttttttttg tatgaaactt ggaggcttac     3540

aggtatagac agctttcagc tacagcacat tctaattttt tattttgttt agttcttttg     3600

tattcacttc tggtctcttt aagactgttt taaaagaaat caatttaggg aaccccagtt     3660

atataatata aactttgtaa tctgagagaa aaaatgtata gtaaatctaa gtcttgattt     3720

ttaactttct attgtaaaaa ataataatat acagagttta atagaaggtg atgttttggt     3780

tttgttttcc cagaggctgc catatggtct ttgagtacgg ggatgtccca aactggccca     3840

ccaatgagca tggcggctcc ggccaggaat gccagagtta gcctcccagg cttgcgggtg     3900

gacatgcctg ctccctgcca gcctccagtg gcctggccag gccctcccga gcctgtctgc     3960

cctccccagg ggtggaggag tctctgggcc ccaggaggat tccctcccgg agactcgcac     4020

ggtgctccct gctcacgcgt tgtcacagtt agtccggaaa tgactgaaac caggcattct     4080

cccggacctc agcgtggggg agcctccagg cagacgctgg gtatggagct gtggtgtggt     4140

ctgtcctgta tggtggccag tgctttctgc cagcatttct ggatggatat agggactatc     4200

attagtatcc taatacacgg tgattttaaa acaaccataa aattgattca gagtccactg     4260

acccttacag atgtaggtat acccttactg gagagggaac tctgatgagg agatgctggt     4320

aaattatcat tttttaaatt gctggtgagt ctgacacttg gtgagttttc agccagtttg     4380

ttaaactttt aattaagttt tgtttataat aaaaatataa atggatttga aagtttccat     4440

tttttaaagt taccctcgtt ttcaaaggta ttttctaaac agatctttaa tggactattt     4500

aaaccgaatt taaggaattc acacacgaca gttgacaggt cttcacgcag gctggttggt     4560

aacgtgctgc cagcacaggg ctgggtgata cgtacaccct aagccggggg tgcctggggc     4620

tggggggcgc tccttgcaat gcccctccag ccacagggca gtgaggtgct gcctgtgtga     4680

gccgtcgggg gagcggccgg ctgtgggggc agcgcagcag gagcatcgtg gggcctttcc     4740

ttctcggctg gttctctgtg acggtggcgt cggctcgcct ctgctccttt catctagaaa     4800

gaagccactg accctgacag cccacggcgg gtacactgag cagctgcatt ggtgctgtca     4860

cttttttaag gctttctgtc cagacttcaa cactggtttc ttttcagagt ttcgaaggat     4920

taatgacttc ctcagcgccc ttgctggcgg gctgagggtg acagtcacgt ccgtttcttc     4980

tgtattagaa ggctgcggtg attcaattag attgtcccac tgctgagacc tgtagggcag     5040

cttctaacat gcttttttca aggggagagg agtagtgaca agtcgtgtgt cggaattgga     5100

tttgagaaca ctctgaatga cccctggagg ccgagggggc aggcttcggg cgtgaactga     5160

actccagacc cctctttgtg ttgggcagtg tcatcttgct tacaaactgt aagacacatt     5220

tttttgtgtg tttgtttttg ttgttgttct tttgcagcac tcacgcctct gacagtcttt     5280

tgggaaagag taacacccac atacagaatt tgtcacatcc agagtagcac tgttccttaa     5340

tactggcata atgcttccag gaagtttttc ttttttatat ttaaaatgtt acttttctgt     5400

atgatgtgca tgcaagttta ccgtaacttt tcttaaactt tttagtgccg tttctagtat     5460

attcctgtaa atgtcagtta ctgaaaatga gtccaatgta agtagtttag cttgtttatt     5520

gcaatgctgg cctcaacaca acagaataaa aatggtagaa agtactcttt gatgtttctg     5580

gtaatcatgg acccttctcc tggggcattt gttttgtttt cataataaaa agcaaaaaaa     5640

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                                  5673


<210> 6
<211> 726
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..726
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 6
Met Ser Thr Ala Thr Thr Val Ala Pro Ala Gly Ile Pro Ala Thr Pro 
1               5                   10                   15    
Gly Pro Val Asn Pro Pro Pro Pro Glu Val Ser Asn Pro Ser Lys Pro 
            20                   25                  30        
Gly Arg Lys Thr Asn Gln Leu Gln Tyr Met Gln Asn Val Val Val Lys 
        35                   40                  45            
Thr Leu Trp Lys His Gln Phe Ala Trp Pro Phe Tyr Gln Pro Val Asp 
    50                   55                  60                
Ala Ile Lys Leu Asn Leu Pro Asp Tyr His Lys Ile Ile Lys Asn Pro 
65                   70                  75                  80
Met Asp Met Gly Thr Ile Lys Lys Arg Leu Glu Asn Asn Tyr Tyr Trp 
                85                   90                  95    
Ser Ala Ser Glu Cys Met Gln Asp Phe Asn Thr Met Phe Thr Asn Cys 
            100                  105                110        
Tyr Ile Tyr Asn Lys Pro Thr Asp Asp Ile Val Leu Met Ala Gln Ala 
        115                  120                125            
Leu Glu Lys Ile Phe Leu Gln Lys Val Ala Gln Met Pro Gln Glu Glu 
    130                  135                140                
Val Glu Leu Leu Pro Pro Ala Pro Lys Gly Lys Gly Arg Lys Pro Ala 
145                  150                155                  160
Ala Gly Ala Gln Ser Ala Gly Thr Gln Gln Val Ala Ala Val Ser Ser 
                165                  170                175    
Val Ser Pro Ala Thr Pro Phe Gln Ser Val Pro Pro Thr Val Ser Gln 
            180                  185                190        
Thr Pro Val Ile Ala Ala Thr Pro Val Pro Thr Ile Thr Ala Asn Val 
        195                  200                205            
Thr Ser Val Pro Val Pro Pro Ala Ala Ala Pro Pro Pro Pro Ala Thr 
    210                  215                220                
Pro Ile Val Pro Val Val Pro Pro Thr Pro Pro Val Val Lys Lys Lys 
225                  230                235                  240
Gly Val Lys Arg Lys Ala Asp Thr Thr Thr Pro Thr Thr Ser Ala Ile 
                245                  250                255    
Thr Ala Ser Arg Ser Glu Ser Pro Pro Pro Leu Ser Asp Pro Lys Gln 
            260                  265                270        
Ala Lys Val Val Ala Arg Arg Glu Ser Gly Gly Arg Pro Ile Lys Pro 
        275                  280                285            
Pro Lys Lys Asp Leu Glu Asp Gly Glu Val Pro Gln His Ala Gly Lys 
    290                  295                300                
Lys Gly Lys Leu Ser Glu His Leu Arg Tyr Cys Asp Ser Ile Leu Arg 
305                  310                315                  320
Glu Met Leu Ser Lys Lys His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys 
                325                  330                335    
Pro Val Asp Ala Glu Ala Leu Glu Leu His Asp Tyr His Asp Ile Ile 
            340                  345                350        
Lys His Pro Met Asp Leu Ser Thr Val Lys Arg Lys Met Asp Gly Arg 
        355                  360                365            
Glu Tyr Pro Asp Ala Gln Gly Phe Ala Ala Asp Val Arg Leu Met Phe 
    370                  375                380                
Ser Asn Cys Tyr Lys Tyr Asn Pro Pro Asp His Glu Val Val Ala Met 
385                  390                395                  400
Ala Arg Lys Leu Gln Asp Val Phe Glu Met Arg Phe Ala Lys Met Pro 
                405                  410                415    
Asp Glu Pro Val Glu Ala Pro Ala Leu Pro Ala Pro Ala Ala Pro Met 
            420                  425                430        
Val Ser Lys Gly Ala Glu Ser Ser Arg Ser Ser Glu Glu Ser Ser Ser 
        435                  440                445            
Asp Ser Gly Ser Ser Asp Ser Glu Glu Glu Arg Ala Thr Arg Leu Ala 
    450                  455                460                
Glu Leu Gln Glu Gln Leu Lys Ala Val His Glu Gln Leu Ala Ala Leu 
465                  470                475                  480
Ser Gln Ala Pro Val Asn Lys Pro Lys Lys Lys Lys Glu Lys Lys Glu 
                485                  490                495    
Lys Glu Lys Lys Lys Lys Asp Lys Glu Lys Glu Lys Glu Lys His Lys 
            500                  505                510        
Val Lys Ala Glu Glu Glu Lys Lys Ala Lys Val Ala Pro Pro Ala Lys 
        515                  520                525            
Gln Ala Gln Gln Lys Lys Ala Pro Ala Lys Lys Ala Asn Ser Thr Thr 
    530                  535                540                
Thr Ala Gly Arg Gln Leu Lys Lys Gly Gly Lys Gln Ala Ser Ala Ser 
545                  550                555                  560
Tyr Asp Ser Glu Glu Glu Glu Glu Gly Leu Pro Met Ser Tyr Asp Glu 
                565                  570                575    
Lys Arg Gln Leu Ser Leu Asp Ile Asn Arg Leu Pro Gly Glu Lys Leu 
            580                  585                590        
Gly Arg Val Val His Ile Ile Gln Ser Arg Glu Pro Ser Leu Arg Asp 
        595                  600                605            
Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe Glu Thr Leu Lys Pro Thr 
    610                  615                620                
Thr Leu Arg Glu Leu Glu Arg Tyr Val Lys Ser Cys Leu Gln Lys Lys 
625                  630                635                  640
Gln Arg Lys Pro Phe Ser Ala Ser Gly Lys Lys Gln Ala Ala Lys Ser 
                645                  650                655    
Lys Glu Glu Leu Ala Gln Glu Lys Lys Lys Glu Leu Glu Lys Arg Leu 
            660                  665                670        
Gln Asp Val Ser Gly Gln Leu Ser Ser Ser Lys Lys Pro Ala Arg Lys 
        675                  680                685            
Glu Lys Pro Gly Ser Ala Pro Ser Gly Gly Pro Ser Arg Leu Ser Ser 
    690                  695                700                
Ser Ser Ser Ser Glu Ser Gly Ser Ser Ser Ser Ser Gly Ser Ser Ser 
705                  710                715                  720
Asp Ser Ser Asp Ser Glu 
                725    

<210> 7
<211> 2472
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..2472
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 7
aagtggccgt ggaggcggaa gtggcgcggc cgcggagggg cctggagtgc ggcggcggcg      60

ggacccggag caggagcggc ggcagcagcg actgggggcg gcggcggcgc gttggaggcg     120

gccatggcaa agcagtacga ctcggtggag tgcccttttt gtgatgaagt ttccaaatac     180

gagaagctcg ccaagatcgg ccaaggcacc ttcggggagg tgttcaaggc caggcaccgc     240

aagaccggcc agaaggtggc tctgaagaag gtgctgatgg aaaacgagaa ggaggggttc     300

cccattacag ccttgcggga gatcaagatc cttcagcttc taaaacacga gaatgtggtc     360

aacttgattg agatttgtcg aaccaaagct tccccctata accgctgcaa gggtagtata     420

tacctggtgt tcgacttctg cgagcatgac cttgctgggc tgttgagcaa tgttttggtc     480

aagttcacgc tgtctgagat caagagggtg atgcagatgc tgcttaacgg cctctactac     540

atccacagaa acaagatcct gcatagggac atgaaggctg ctaatgtgct tatcactcgt     600

gatggggtcc tgaagctggc agactttggg ctggcccggg ccttcagcct ggccaagaac     660

agccagccca accgctacac caaccgtgtg gtgacactct ggtaccggcc cccggagctg     720

ttgctcgggg agcgggacta cggccccccc attgacctgt ggggtgctgg gtgcatcatg     780

gcagagatgt ggacccgcag ccccatcatg cagggcaaca cggagcagca ccaactcgcc     840

ctcatcagtc agctctgcgg ctccatcacc cctgaggtgt ggccaaacgt ggacaactat     900

gagctgtacg aaaagctgga gctggtcaag ggccagaagc ggaaggtgaa ggacaggctg     960

aaggcctatg tgcgtgaccc atacgcactg gacctcatcg acaagctgct ggtgctggac    1020

cctgcccagc gcatcgacag cgatgacgcc ctcaaccacg acttcttctg gtccgacccc    1080

atgccctccg acctcaaggg catgctctcc acccacctga cgtccatgtt cgagtacttg    1140

gcaccaccgc gccggaaggg cagccagatc acccagcagt ccaccaacca gagtcgcaat    1200

cccgccacca ccaaccagac ggagtttgag cgcgtcttct gagggccggc gcttgccact    1260

agggctcttg tgtttttttt cttctgctat gtgacttgca tcgtggagac agggcatttg    1320

agtttatatc tctcatgcat attttattta atccccaccc tgggctctgg gagcagcccg    1380

ctgagtggac tggagtggag cattggctga gagaccagga gggcactgga gctgtcttgt    1440

ccttgctggt tttctggatg gttcccagag ggtttccatg gggtaggagg atgggctcgc    1500

ccaccagtga ctttttctaa gagctcccgg cgtggtggaa gaggggacag gtccctcacc    1560

cacccacaat cctattctcg ggctgagaac cctgcgtggg gacagggctc gcctcaggaa    1620

tgggctgttt ttggcctaac cctcagaaac actggggctg gcacaaactc ttggtttctt    1680

caacaggaga attttactgt gtttcttttg gttccattgt ttggagacat tcctgggcac    1740

agtttggtcc gttagaatta aaagttgaat tttttttttt tttaaatttt tttttttcct    1800

ccaggacttg tgtgttttgt tctgcgcaca caccgccaac tgttccccca cagtcagcag    1860

caggttgggc ctgaccattg ggacttgatt gtcaagtcac tggaggtctt gactttttta    1920

tctcagttca tgttctcttc cataattgga aaggaccttt gtctgttttt cctcttgggt    1980

gccttccaga acgcatctca tgtccctggt gagggaattg gtgagggcct gctgtgagct    2040

gctgtggctg cgatggtcac ccagctgggc aaatcactgg agtgacaatt tgacctgtca    2100

cctgagaagg atggtccctc agactgctgg gtagagggcc tggggcaggc tggagagaga    2160

aagtgggcag agggtgaagg gatcacaggg gtcttggaag gtggcagtag tttggacggg    2220

ggtggggagt atgtgggaga aaaaaacaga ctgaaggtag aatccttggg aacctttgag    2280

gagcggcaca ttctggcagg cacgttttct gtgagcctga agttaggaag agacattctg    2340

gaggtcaatt tcctacatcc tcttacaggc ggagaccttg aagtggggcc aggaaggaag    2400

gttggcaaaa cctttgacca gaactgtcct tcatttacag aaactgaccc agaccacaac    2460

acaaaaggcc ag                                                        2472


<210> 8
<211> 372
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..372
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 8
Met Ala Lys Gln Tyr Asp Ser Val Glu Cys Pro Phe Cys Asp Glu Val 
1               5                   10                   15    
Ser Lys Tyr Glu Lys Leu Ala Lys Ile Gly Gln Gly Thr Phe Gly Glu 
            20                   25                  30        
Val Phe Lys Ala Arg His Arg Lys Thr Gly Gln Lys Val Ala Leu Lys 
        35                   40                  45            
Lys Val Leu Met Glu Asn Glu Lys Glu Gly Phe Pro Ile Thr Ala Leu 
    50                   55                  60                
Arg Glu Ile Lys Ile Leu Gln Leu Leu Lys His Glu Asn Val Val Asn 
65                   70                  75                  80
Leu Ile Glu Ile Cys Arg Thr Lys Ala Ser Pro Tyr Asn Arg Cys Lys 
                85                   90                  95    
Gly Ser Ile Tyr Leu Val Phe Asp Phe Cys Glu His Asp Leu Ala Gly 
            100                  105                110        
Leu Leu Ser Asn Val Leu Val Lys Phe Thr Leu Ser Glu Ile Lys Arg 
        115                  120                125            
Val Met Gln Met Leu Leu Asn Gly Leu Tyr Tyr Ile His Arg Asn Lys 
    130                  135                140                
Ile Leu His Arg Asp Met Lys Ala Ala Asn Val Leu Ile Thr Arg Asp 
145                  150                155                  160
Gly Val Leu Lys Leu Ala Asp Phe Gly Leu Ala Arg Ala Phe Ser Leu 
                165                  170                175    
Ala Lys Asn Ser Gln Pro Asn Arg Tyr Thr Asn Arg Val Val Thr Leu 
            180                  185                190        
Trp Tyr Arg Pro Pro Glu Leu Leu Leu Gly Glu Arg Asp Tyr Gly Pro 
        195                  200                205            
Pro Ile Asp Leu Trp Gly Ala Gly Cys Ile Met Ala Glu Met Trp Thr 
    210                  215                220                
Arg Ser Pro Ile Met Gln Gly Asn Thr Glu Gln His Gln Leu Ala Leu 
225                  230                235                  240
Ile Ser Gln Leu Cys Gly Ser Ile Thr Pro Glu Val Trp Pro Asn Val 
                245                  250                255    
Asp Asn Tyr Glu Leu Tyr Glu Lys Leu Glu Leu Val Lys Gly Gln Lys 
            260                  265                270        
Arg Lys Val Lys Asp Arg Leu Lys Ala Tyr Val Arg Asp Pro Tyr Ala 
        275                  280                285            
Leu Asp Leu Ile Asp Lys Leu Leu Val Leu Asp Pro Ala Gln Arg Ile 
    290                  295                300                
Asp Ser Asp Asp Ala Leu Asn His Asp Phe Phe Trp Ser Asp Pro Met 
305                  310                315                  320
Pro Ser Asp Leu Lys Gly Met Leu Ser Thr His Leu Thr Ser Met Phe 
                325                  330                335    
Glu Tyr Leu Ala Pro Pro Arg Arg Lys Gly Ser Gln Ile Thr Gln Gln 
            340                  345                350        
Ser Thr Asn Gln Ser Arg Asn Pro Ala Thr Thr Asn Gln Thr Glu Phe 
        355                  360                365            
Glu Arg Val Phe 
    370        

<210> 9
<211> 2568
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..2568
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 9
gggaagatac acggttttta agaaagaact tctaacccca ctccaccgcc caacggtcac      60

gtgacgcgcc tgcgtcctcg cctcaaggtt ttttctggtc gcatattggc tgttaactcg     120

gctacggggt gtagcgaggt gcattccgga agtaggtcct ttgacttttg cttcctctac     180

ggaggcaagt aacaacccgg cggtcgacgc ttagcggaag ttcgtcaagt cgcagttgcc     240

cccgcacagc ggatgtgggt cgcctcttag gtgacgctgg gaagtgcctg caaccttcgc     300

cgctgccttc tggttgaagc actatggagg gagagaggaa gaacaacaac aaacggtggt     360

atttcactcg agaacagctg gaaaatagcc catcccgtcg ttttggcgtg gacccagata     420

aagaactttc ttatcgccag caggcggcca atctgcttca ggacatgggg cagcgtctta     480

acgtctcaca attgactatc aacactgcta tagtatacat gcatcgattc tacatgattc     540

agtccttcac acagttccct ggaaattctg tggctccagc agccttgttt ctagcagcta     600

aagtggagga gcagcccaaa aaattggaac atgtcatcaa ggtagcacat acttgtctcc     660

atcctcagga atcccttcct gatactagaa gtgaggctta tttgcaacaa gttcaagatc     720

tggtcatttt agaaagcata attttgcaga ctttaggctt tgaactaaca attgatcacc     780

cacatactca tgtagtaaag tgcactcaac ttgttcgagc aagcaaggac ttagcacaga     840

cttcttactt catggcaacc aacagcctgc atttgaccac atttagcctg cagtacacac     900

ctcctgtggt ggcctgtgtc tgcattcacc tggcttgcaa gtggtccaat tgggagatcc     960

cagtctcaac tgacgggaag cactggtggg agtatgttga cgccactgtg accttggaac    1020

ttttagatga actgacacat gagtttctac agattttgga gaaaactccc aacaggctca    1080

aacgcatttg gaattggagg gcatgcgagg ctgccaagaa aacaaaagca gatgaccgag    1140

gaacagatga aaagacttca gagcagacaa tcctcaatat gatttcccag agctcttcag    1200

acacaaccat tgcaggttta atgagcatgt caacttctac cacaagtgca gtgccttccc    1260

tgccagtctc cgaagagtca tccagcaact taaccagtgt ggagatgttg ccgggcaagc    1320

gttggctgtc ctcccaacct tctttcaaac tagaacctac tcagggtcat cggactagtg    1380

agaatttagc acttacagga gttgatcatt ccttaccaca ggatggttca aatgcattta    1440

tttcccagaa gcagaatagt aagagtgtgc catcagctaa agtgtcactg aaagaatacc    1500

gcgcgaagca tgcagaagaa ttggctgccc agaagaggca actggagaac atggaagcca    1560

atgtgaagtc acaatatgca tatgctgccc agaatctcct ttctcatcat gatagccatt    1620

cttcagtcat tctaaaaatg cccatagagg gttcagaaaa ccccgagcgg ccttttctgg    1680

aaaaggctga caaaacagct ctcaaaatga gaatcccagt ggcaggtgga gataaagctg    1740

cgtcttcaaa accagaggag ataaaaatgc gcataaaagt ccatgctgca gctgataagc    1800

acaattctgt agaggacagt gttacaaaga gccgagagca caaagaaaag cacaagactc    1860

acccatctaa tcatcatcat catcataatc accactcaca caagcactct cattcccaac    1920

ttccagttgg tactgggaac aaacgtcctg gtgatccaaa acatagtagc cagacaagca    1980

acttagcaca taaaacctat agcttgtcta gttctttttc ctcttccagt tctactcgta    2040

aaaggggacc ctctgaagag actggagggg ctgtgtttga tcatccagcc aagattgcca    2100

agagtactaa atcctcttcc ctaaatttct ccttcccttc acttcctaca atgggtcaga    2160

tgcctgggca tagctcagac acaagtggcc tttccttttc acagcccagc tgtaaaactc    2220

gtgtccctca ttcgaaactg gataaagggc ccactggggc caatggtcac aacacgaccc    2280

agacaataga ctatcaagac actgtgaata tgcttcactc cctgctcagt gcccagggtg    2340

ttcagcccac tcagcccact gcatttgaat ttgttcgtcc ttatagtgac tatctgaatc    2400

ctcggtctgg tggaatctcc tcgagatctg gcaatacaga caaaccccgg ccaccacctc    2460

tgccatcaga acctcctcca ccacttccac cccttcctaa gtaaaaaaag aaaaagaaga    2520

ggagaaaaaa acttctttaa aaaaacacat aatttttctt tttttttt                 2568


<210> 10
<211> 726
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..726
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 10
Met Glu Gly Glu Arg Lys Asn Asn Asn Lys Arg Trp Tyr Phe Thr Arg 
1               5                   10                   15    
Glu Gln Leu Glu Asn Ser Pro Ser Arg Arg Phe Gly Val Asp Pro Asp 
            20                   25                  30        
Lys Glu Leu Ser Tyr Arg Gln Gln Ala Ala Asn Leu Leu Gln Asp Met 
        35                   40                  45            
Gly Gln Arg Leu Asn Val Ser Gln Leu Thr Ile Asn Thr Ala Ile Val 
    50                   55                  60                
Tyr Met His Arg Phe Tyr Met Ile Gln Ser Phe Thr Gln Phe Pro Gly 
65                   70                  75                  80
Asn Ser Val Ala Pro Ala Ala Leu Phe Leu Ala Ala Lys Val Glu Glu 
                85                   90                  95    
Gln Pro Lys Lys Leu Glu His Val Ile Lys Val Ala His Thr Cys Leu 
            100                  105                110        
His Pro Gln Glu Ser Leu Pro Asp Thr Arg Ser Glu Ala Tyr Leu Gln 
        115                  120                125            
Gln Val Gln Asp Leu Val Ile Leu Glu Ser Ile Ile Leu Gln Thr Leu 
    130                  135                140                
Gly Phe Glu Leu Thr Ile Asp His Pro His Thr His Val Val Lys Cys 
145                  150                155                  160
Thr Gln Leu Val Arg Ala Ser Lys Asp Leu Ala Gln Thr Ser Tyr Phe 
                165                  170                175    
Met Ala Thr Asn Ser Leu His Leu Thr Thr Phe Ser Leu Gln Tyr Thr 
            180                  185                190        
Pro Pro Val Val Ala Cys Val Cys Ile His Leu Ala Cys Lys Trp Ser 
        195                  200                205            
Asn Trp Glu Ile Pro Val Ser Thr Asp Gly Lys His Trp Trp Glu Tyr 
    210                  215                220                
Val Asp Ala Thr Val Thr Leu Glu Leu Leu Asp Glu Leu Thr His Glu 
225                  230                235                  240
Phe Leu Gln Ile Leu Glu Lys Thr Pro Asn Arg Leu Lys Arg Ile Trp 
                245                  250                255    
Asn Trp Arg Ala Cys Glu Ala Ala Lys Lys Thr Lys Ala Asp Asp Arg 
            260                  265                270        
Gly Thr Asp Glu Lys Thr Ser Glu Gln Thr Ile Leu Asn Met Ile Ser 
        275                  280                285            
Gln Ser Ser Ser Asp Thr Thr Ile Ala Gly Leu Met Ser Met Ser Thr 
    290                  295                300                
Ser Thr Thr Ser Ala Val Pro Ser Leu Pro Val Ser Glu Glu Ser Ser 
305                  310                315                  320
Ser Asn Leu Thr Ser Val Glu Met Leu Pro Gly Lys Arg Trp Leu Ser 
                325                  330                335    
Ser Gln Pro Ser Phe Lys Leu Glu Pro Thr Gln Gly His Arg Thr Ser 
            340                  345                350        
Glu Asn Leu Ala Leu Thr Gly Val Asp His Ser Leu Pro Gln Asp Gly 
        355                  360                365            
Ser Asn Ala Phe Ile Ser Gln Lys Gln Asn Ser Lys Ser Val Pro Ser 
    370                  375                380                
Ala Lys Val Ser Leu Lys Glu Tyr Arg Ala Lys His Ala Glu Glu Leu 
385                  390                395                  400
Ala Ala Gln Lys Arg Gln Leu Glu Asn Met Glu Ala Asn Val Lys Ser 
                405                  410                415    
Gln Tyr Ala Tyr Ala Ala Gln Asn Leu Leu Ser His His Asp Ser His 
            420                  425                430        
Ser Ser Val Ile Leu Lys Met Pro Ile Glu Gly Ser Glu Asn Pro Glu 
        435                  440                445            
Arg Pro Phe Leu Glu Lys Ala Asp Lys Thr Ala Leu Lys Met Arg Ile 
    450                  455                460                
Pro Val Ala Gly Gly Asp Lys Ala Ala Ser Ser Lys Pro Glu Glu Ile 
465                  470                475                  480
Lys Met Arg Ile Lys Val His Ala Ala Ala Asp Lys His Asn Ser Val 
                485                  490                495    
Glu Asp Ser Val Thr Lys Ser Arg Glu His Lys Glu Lys His Lys Thr 
            500                  505                510        
His Pro Ser Asn His His His His His Asn His His Ser His Lys His 
        515                  520                525            
Ser His Ser Gln Leu Pro Val Gly Thr Gly Asn Lys Arg Pro Gly Asp 
    530                  535                540                
Pro Lys His Ser Ser Gln Thr Ser Asn Leu Ala His Lys Thr Tyr Ser 
545                  550                555                  560
Leu Ser Ser Ser Phe Ser Ser Ser Ser Ser Thr Arg Lys Arg Gly Pro 
                565                  570                575    
Ser Glu Glu Thr Gly Gly Ala Val Phe Asp His Pro Ala Lys Ile Ala 
            580                  585                590        
Lys Ser Thr Lys Ser Ser Ser Leu Asn Phe Ser Phe Pro Ser Leu Pro 
        595                  600                605            
Thr Met Gly Gln Met Pro Gly His Ser Ser Asp Thr Ser Gly Leu Ser 
    610                  615                620                
Phe Ser Gln Pro Ser Cys Lys Thr Arg Val Pro His Ser Lys Leu Asp 
625                  630                635                  640
Lys Gly Pro Thr Gly Ala Asn Gly His Asn Thr Thr Gln Thr Ile Asp 
                645                  650                655    
Tyr Gln Asp Thr Val Asn Met Leu His Ser Leu Leu Ser Ala Gln Gly 
            660                  665                670        
Val Gln Pro Thr Gln Pro Thr Ala Phe Glu Phe Val Arg Pro Tyr Ser 
        675                  680                685            
Asp Tyr Leu Asn Pro Arg Ser Gly Gly Ile Ser Ser Arg Ser Gly Asn 
    690                  695                700                
Thr Asp Lys Pro Arg Pro Pro Pro Leu Pro Ser Glu Pro Pro Pro Pro 
705                  710                715                  720
Leu Pro Pro Leu Pro Lys 
                725    

<210> 11
<211> 8089
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..8089
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 11
gcggcgcgga ggctggcccg ggacgcgccc ggagcccagg gaaggaggga ggaggggagg       60

gtcgcggccg gccgccatgg ggccgggggc ccgtggccgc cgccgccgcc gtcgcccgat      120

gtcgccgcca ccgccaccgc cacccgtgcg ggcgctgccc ctgctgctgc tgctagcggg      180

gccgggggct gcagcccccc cttgcctgga cggaagcccg tgtgcaaatg gaggtcgttg      240

cacccagctg ccctcccggg aggctgcctg cctgtgcccg cctggctggg tgggtgagcg      300

gtgtcagctg gaggacccct gtcactcagg cccctgtgct ggccgtggtg tctgccagag      360

ttcagtggtg gctggcaccg cccgattctc atgccggtgc ccccgtggct tccgaggccc      420

tgactgctcc ctgccagatc cctgcctcag cagcccttgt gcccacggtg cccgctgctc      480

agtggggccc gatggacgct tcctctgctc ctgcccacct ggctaccagg gccgcagctg      540

ccgaagcgac gtggatgagt gccgggtggg tgagccctgc cgccatggtg gcacctgcct      600

caacacacct ggctccttcc gctgccagtg tccagctggc tacacagggc cactatgtga      660

gaaccccgcg gtgccctgtg caccctcacc atgccgtaac gggggcacct gcaggcagag      720

tggcgacctc acttacgact gtgcctgtct tcctgggttt gagggtcaga attgtgaagt      780

gaacgtggac gactgtccag gacaccgatg tctcaatggg gggacatgcg tggatggcgt      840

caacacctat aactgccagt gccctcctga gtggacaggc cagttctgca cggaggacgt      900

ggatgagtgt cagctgcagc ccaacgcctg ccacaatggg ggtacctgct tcaacacgct      960

gggtggccac agctgcgtgt gtgtcaatgg ctggacaggc gagagctgca gtcagaatat     1020

cgatgactgt gccacagccg tgtgcttcca tggggccacc tgccatgacc gcgtggcttc     1080

tttctactgt gcctgcccca tgggcaagac tggcctcctg tgtcacctgg atgacgcctg     1140

tgtcagcaac ccctgccacg aggatgctat ctgtgacaca aatccggtga acggccgggc     1200

catttgcacc tgtcctcccg gcttcacggg tggggcatgt gaccaggatg tggacgagtg     1260

ctctatcggc gccaacccct gcgagcactt gggcaggtgc gtgaacacgc agggctcctt     1320

cctgtgccag tgcggtcgtg gctacactgg acctcgctgt gagaccgatg tcaacgagtg     1380

tctgtcgggg ccctgccgaa accaggccac gtgcctcgac cgcataggcc agttcacctg     1440

tatctgtatg gcaggcttca caggaaccta ttgcgaggtg gacattgacg agtgtcagag     1500

tagcccctgt gtcaacggtg gggtctgcaa ggaccgagtc aatggcttca gctgcacctg     1560

cccctcgggc ttcagcggct ccacgtgtca gctggacgtg gacgaatgcg ccagcacgcc     1620

ctgcaggaat ggcgccaaat gcgtggacca gcccgatggc tacgagtgcc gctgtgccga     1680

gggctttgag ggcacgctgt gtgatcgcaa cgtggacgac tgctcccctg acccatgcca     1740

ccatggtcgc tgcgtggatg gcatcgccag cttctcatgt gcctgtgctc ctggctacac     1800

gggcacacgc tgcgagagcc aggtggacga atgccgcagc cagccctgcc gccatggcgg     1860

caaatgccta gacctggtgg acaagtacct ctgccgctgc ccttctggga ccacaggtgt     1920

gaactgcgaa gtgaacattg acgactgtgc cagcaacccc tgcacctttg gagtctgccg     1980

tgatggcatc aaccgctacg actgtgtctg ccaacctggc ttcacagggc ccctttgtaa     2040

cgtggagatc aatgagtgtg cttccagccc atgcggcgag ggaggttcct gtgtggatgg     2100

ggaaaatggc ttccgctgcc tctgcccgcc tggctccttg cccccactct gcctcccccc     2160

gagccatccc tgtgcccatg agccctgcag tcacggcatc tgctatgatg cacctggcgg     2220

gttccgctgt gtgtgtgagc ctggctggag tggcccccgc tgcagccaga gcctggcccg     2280

agacgcctgt gagtcccagc cgtgcagggc cggtgggaca tgcagcagcg atggaatggg     2340

tttccactgc acctgcccgc ctggtgtcca gggacgtcag tgtgaactcc tctccccctg     2400

caccccgaac ccctgtgagc atgggggccg ctgcgagtct gcccctggcc agctgcctgt     2460

ctgctcctgc ccccagggct ggcaaggccc acgatgccag caggatgtgg acgagtgtgc     2520

tggccccgca ccctgtggcc ctcatggtat ctgcaccaac ctggcaggga gtttcagctg     2580

cacctgccat ggagggtaca ctggcccttc ctgcgatcag gacatcaatg actgtgaccc     2640

caacccatgc ctgaacggtg gctcgtgcca agacggcgtg ggctcctttt cctgctcctg     2700

cctccctggt ttcgccggcc cacgatgcgc ccgcgatgtg gatgagtgcc tgagcaaccc     2760

ctgcggcccg ggcacctgta ccgaccacgt ggcctccttc acctgcacct gcccgccagg     2820

ctacggaggc ttccactgcg aacaggacct gcccgactgc agccccagct cctgcttcaa     2880

tggcgggacc tgtgtggacg gcgtgaactc gttcagctgc ctgtgccgtc ccggctacac     2940

aggagcccac tgccaacatg aggcagaccc ctgcctctcg cggccctgcc tacacggggg     3000

cgtctgcagc gccgcccacc ctggcttccg ctgcacctgc ctcgagagct tcacgggccc     3060

gcagtgccag acgctggtgg attggtgcag ccgccagcct tgtcaaaacg ggggtcgctg     3120

cgtccagact ggggcctatt gcctttgtcc ccctggatgg agcggacgcc tctgtgacat     3180

ccgaagcttg ccctgcaggg aggccgcagc ccagatcggg gtgcggctgg agcagctgtg     3240

tcaggcgggt gggcagtgtg tggatgaaga cagctcccac tactgcgtgt gcccagaggg     3300

ccgtactggt agccactgtg agcaggaggt ggacccctgc ttggcccagc cctgccagca     3360

tggggggacc tgccgtggct atatgggggg ctacatgtgt gagtgtcttc ctggctacaa     3420

tggtgataac tgtgaggacg acgtggacga gtgtgcctcc cagccctgcc agcacggggg     3480

ttcatgcatt gacctcgtgg cccgctatct ctgctcctgt cccccaggaa cgctgggggt     3540

gctctgcgag attaatgagg atgactgcgg cccaggccca ccgctggact cagggccccg     3600

gtgcctacac aatggcacct gcgtggacct ggtgggtggt ttccgctgca cctgtccccc     3660

aggatacact ggtttgcgct gcgaggcaga catcaatgag tgtcgctcag gtgcctgcca     3720

cgcggcacac acccgggact gcctgcagga cccaggcgga ggtttccgtt gcctttgtca     3780

tgctggcttc tcaggtcctc gctgtcagac tgtcctgtct ccctgcgagt cccagccatg     3840

ccagcatgga ggccagtgcc gtcctagccc gggtcctggg ggtgggctga ccttcacctg     3900

tcactgtgcc cagccgttct ggggtccgcg ttgcgagcgg gtggcgcgct cctgccggga     3960

gctgcagtgc ccggtgggcg tcccatgcca gcagacgccc cgcgggccgc gctgcgcctg     4020

ccccccaggg ttgtcgggac cctcctgccg cagcttcccg gggtcgccgc cgggggccag     4080

caacgccagc tgcgcggccg ccccctgtct ccacgggggc tcctgccgcc ccgcgccgct     4140

cgcgcccttc ttccgctgcg cttgcgcgca gggctggacc gggccgcgct gcgaggcgcc     4200

cgccgcggca cccgaggtct cggaggagcc gcggtgcccg cgcgccgcct gccaggccaa     4260

gcgcggggac cagcgctgcg accgcgagtg caacagccca ggctgcggct gggacggcgg     4320

cgactgctcg ctgagcgtgg gcgacccctg gcggcaatgc gaggcgctgc agtgctggcg     4380

cctcttcaac aacagccgct gcgaccccgc ctgcagctcg cccgcctgcc tctacgacaa     4440

cttcgactgc cacgccggtg gccgcgagcg cacttgcaac ccggtgtacg agaagtactg     4500

cgccgaccac tttgccgacg gccgctgcga ccagggctgc aacacggagg agtgcggctg     4560

ggatgggctg gattgtgcca gcgaggtgcc ggccctgctg gcccgcggcg tgctggtgct     4620

cacagtgctg ctgccgccag aggagctact gcgttccagc gccgactttc tgcagcggct     4680

cagcgccatc ctgcgcacct cgctgcgctt ccgcctggac gcgcacggcc aggccatggt     4740

cttcccttac caccggccta gtcctggctc cgaaccccgg gcccgtcggg agctggcccc     4800

cgaggtgatc ggctcggtag taatgctgga gattgacaac cggctctgcc tgcagtcgcc     4860

tgagaatgat cactgcttcc ccgatgccca gagcgccgct gactacctgg gagcgttgtc     4920

agcggtggag cgcctggact tcccgtaccc actgcgggac gtgcgggggg agccgctgga     4980

gcctccagaa cccagcgtcc cgctgctgcc actgctagtg gcgggcgctg tcttgctgct     5040

ggtcattctc gtcctgggtg tcatggtggc ccggcgcaag cgcgagcaca gcaccctctg     5100

gttccctgag ggcttctcac tgcacaagga cgtggcctct ggtcacaagg gccggcggga     5160

acccgtgggc caggacgcgc tgggcatgaa gaacatggcc aagggtgaga gcctgatggg     5220

ggaggtggcc acagactgga tggacacaga gtgcccagag gccaagcggc taaaggtaga     5280

ggagccaggc atgggggctg aggaggctgt ggattgccgt cagtggactc aacaccatct     5340

ggttgctgct gacatccgcg tggcaccagc catggcactg acaccaccac agggcgacgc     5400

agatgctgat ggcatggatg tcaatgtgcg tggcccagat ggcttcaccc cgctaatgct     5460

ggcttccttc tgtggggggg ctctggagcc aatgccaact gaagaggatg aggcagatga     5520

cacatcagct agcatcatct ccgacctgat ctgccagggg gctcagcttg gggcacggac     5580

tgaccgtact ggcgagactg ctttgcacct ggctgcccgt tatgcccgtg ctgatgcagc     5640

caagcggctg ctggatgctg gggcagacac caatgcccag gaccactcag gccgcactcc     5700

cctgcacaca gctgtcacag ccgatgccca gggtgtcttc cagattctca tccgaaaccg     5760

ctctacagac ttggatgccc gcatggcaga tggctcaacg gcactgatcc tggcggcccg     5820

cctggcagta gagggcatgg tggaagagct catcgccagc catgctgatg tcaatgctgt     5880

ggatgagctt gggaaatcag ccttacactg ggctgcggct gtgaacaacg tggaagccac     5940

tttggccctg ctcaaaaatg gagccaataa ggacatgcag gatagcaagg aggagacccc     6000

cctattcctg gccgcccgcg agggcagcta tgaggctgcc aagctgctgt tggaccactt     6060

tgccaaccgt gagatcaccg accacctgga caggctgccg cgggacgtag cccaggagag     6120

actgcaccag gacatcgtgc gcttgctgga tcaacccagt gggccccgca gcccccccgg     6180

tccccacggc ctggggcctc tgctctgtcc tccaggggcc ttcctccctg gcctcaaagc     6240

ggcacagtcg gggtccaaga agagcaggag gccccccggg aaggcggggc tggggccgca     6300

ggggccccgg gggcggggca agaagctgac gctggcctgc ccgggccccc tggctgacag     6360

ctcggtcacg ctgtcgcccg tggactcgct ggactccccg cggcctttcg gtgggccccc     6420

tgcttcccct ggtggcttcc cccttgaggg gccctatgca gctgccactg ccactgcagt     6480

gtctctggca cagcttggtg gcccaggccg ggcgggtcta gggcgccagc cccctggagg     6540

atgtgtactc agcctgggcc tgctgaaccc tgtggctgtg cccctcgatt gggcccggct     6600

gcccccacct gcccctccag gcccctcgtt cctgctgcca ctggcgccgg gaccccagct     6660

gctcaaccca gggacccccg tctccccgca ggagcggccc ccgccttacc tggcagtccc     6720

aggacatggc gaggagtacc cggcggctgg ggcacacagc agccccccaa aggcccgctt     6780

cctgcgggtt cccagtgagc acccttacct gaccccatcc cccgaatccc ctgagcactg     6840

ggccagcccc tcacctccct ccctctcaga ctggtccgaa tccacgccta gcccagccac     6900

tgccactggg gccatggcca ccaccactgg ggcactgcct gcccagccac ttcccttgtc     6960

tgttcccagc tcccttgctc aggcccagac ccagctgggg ccccagccgg aagttacccc     7020

caagaggcaa gtgttggcct gagacgctcg tcagttctta gatcttgggg gcctaaagag     7080

acccccgtcc tgcctccttt ctttctctgt ctcttccttc cttttagtct ttttcatcct     7140

cttctctttc caccaaccct cctgcatcct tgccttgcag cgtgaccgag ataggtcatc     7200

agcccagggc ttcagtcttc ctttatttat aatgggtggg ggctaccacc caccctctca     7260

gtcttgtgaa gagtctggga cctccttctt ccccacttct ctcttccctc attcctttct     7320

ctctccttct ggcctctcat ttccttacac tctgacatga atgaattatt attattttta     7380

tttttctttt tttttttaca ttttgtatag aaacaaattc atttaaacaa acttattatt     7440

attatttttt acaaaatata tatatggaga tgctccctcc ccctgtgaac cccccagtgc     7500

ccccgtgggg ctgagtctgt gggcccattc ggccaagctg gattctgtgt acctagtaca     7560

caggcatgac tgggatcccg tgtaccgagt acacgaccca ggtatgtacc aagtaggcac     7620

ccttgggcgc acccactggg gccaggggtc gggggagtgt tgggagcctc ctccccaccc     7680

cacctccctc acttcactgc attccagatg ggacatgttc catagccttg ctggggaagg     7740

gcccactgcc aactccctct gccccagccc cacccttggc catctccctt tgggaactag     7800

ggggctgctg gtgggaaatg ggagccaggg cagatgtatg cattcctttg tgtccctgta     7860

aatgtgggac tacaagaaga ggagctgcct gagtggtact ttctcttcct ggtaatcctc     7920

tggcccagcc tcatggcaga atagaggtat ttttaggcta tttttgtaat atggcttctg     7980

gtcaaaatcc ctgtgtagct gaattcccaa gccctgcatt gtacagcccc ccactcccct     8040

caccacctaa taaaggaata gttaacactc aaaaaaaaaa aaaaaaaaa                 8089


<210> 12
<211> 2321
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..2321
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 12
Met Gly Pro Gly Ala Arg Gly Arg Arg Arg Arg Arg Arg Pro Met Ser 
1               5                   10                   15    
Pro Pro Pro Pro Pro Pro Pro Val Arg Ala Leu Pro Leu Leu Leu Leu 
            20                   25                  30        
Leu Ala Gly Pro Gly Ala Ala Ala Pro Pro Cys Leu Asp Gly Ser Pro 
        35                   40                  45            
Cys Ala Asn Gly Gly Arg Cys Thr Gln Leu Pro Ser Arg Glu Ala Ala 
    50                   55                  60                
Cys Leu Cys Pro Pro Gly Trp Val Gly Glu Arg Cys Gln Leu Glu Asp 
65                   70                  75                  80
Pro Cys His Ser Gly Pro Cys Ala Gly Arg Gly Val Cys Gln Ser Ser 
                85                   90                  95    
Val Val Ala Gly Thr Ala Arg Phe Ser Cys Arg Cys Pro Arg Gly Phe 
            100                  105                110        
Arg Gly Pro Asp Cys Ser Leu Pro Asp Pro Cys Leu Ser Ser Pro Cys 
        115                  120                125            
Ala His Gly Ala Arg Cys Ser Val Gly Pro Asp Gly Arg Phe Leu Cys 
    130                  135                140                
Ser Cys Pro Pro Gly Tyr Gln Gly Arg Ser Cys Arg Ser Asp Val Asp 
145                  150                155                  160
Glu Cys Arg Val Gly Glu Pro Cys Arg His Gly Gly Thr Cys Leu Asn 
                165                  170                175    
Thr Pro Gly Ser Phe Arg Cys Gln Cys Pro Ala Gly Tyr Thr Gly Pro 
            180                  185                190        
Leu Cys Glu Asn Pro Ala Val Pro Cys Ala Pro Ser Pro Cys Arg Asn 
        195                  200                205            
Gly Gly Thr Cys Arg Gln Ser Gly Asp Leu Thr Tyr Asp Cys Ala Cys 
    210                  215                220                
Leu Pro Gly Phe Glu Gly Gln Asn Cys Glu Val Asn Val Asp Asp Cys 
225                  230                235                  240
Pro Gly His Arg Cys Leu Asn Gly Gly Thr Cys Val Asp Gly Val Asn 
                245                  250                255    
Thr Tyr Asn Cys Gln Cys Pro Pro Glu Trp Thr Gly Gln Phe Cys Thr 
            260                  265                270        
Glu Asp Val Asp Glu Cys Gln Leu Gln Pro Asn Ala Cys His Asn Gly 
        275                  280                285            
Gly Thr Cys Phe Asn Thr Leu Gly Gly His Ser Cys Val Cys Val Asn 
    290                  295                300                
Gly Trp Thr Gly Glu Ser Cys Ser Gln Asn Ile Asp Asp Cys Ala Thr 
305                  310                315                  320
Ala Val Cys Phe His Gly Ala Thr Cys His Asp Arg Val Ala Ser Phe 
                325                  330                335    
Tyr Cys Ala Cys Pro Met Gly Lys Thr Gly Leu Leu Cys His Leu Asp 
            340                  345                350        
Asp Ala Cys Val Ser Asn Pro Cys His Glu Asp Ala Ile Cys Asp Thr 
        355                  360                365            
Asn Pro Val Asn Gly Arg Ala Ile Cys Thr Cys Pro Pro Gly Phe Thr 
    370                  375                380                
Gly Gly Ala Cys Asp Gln Asp Val Asp Glu Cys Ser Ile Gly Ala Asn 
385                  390                395                  400
Pro Cys Glu His Leu Gly Arg Cys Val Asn Thr Gln Gly Ser Phe Leu 
                405                  410                415    
Cys Gln Cys Gly Arg Gly Tyr Thr Gly Pro Arg Cys Glu Thr Asp Val 
            420                  425                430        
Asn Glu Cys Leu Ser Gly Pro Cys Arg Asn Gln Ala Thr Cys Leu Asp 
        435                  440                445            
Arg Ile Gly Gln Phe Thr Cys Ile Cys Met Ala Gly Phe Thr Gly Thr 
    450                  455                460                
Tyr Cys Glu Val Asp Ile Asp Glu Cys Gln Ser Ser Pro Cys Val Asn 
465                  470                475                  480
Gly Gly Val Cys Lys Asp Arg Val Asn Gly Phe Ser Cys Thr Cys Pro 
                485                  490                495    
Ser Gly Phe Ser Gly Ser Thr Cys Gln Leu Asp Val Asp Glu Cys Ala 
            500                  505                510        
Ser Thr Pro Cys Arg Asn Gly Ala Lys Cys Val Asp Gln Pro Asp Gly 
        515                  520                525            
Tyr Glu Cys Arg Cys Ala Glu Gly Phe Glu Gly Thr Leu Cys Asp Arg 
    530                  535                540                
Asn Val Asp Asp Cys Ser Pro Asp Pro Cys His His Gly Arg Cys Val 
545                  550                555                  560
Asp Gly Ile Ala Ser Phe Ser Cys Ala Cys Ala Pro Gly Tyr Thr Gly 
                565                  570                575    
Thr Arg Cys Glu Ser Gln Val Asp Glu Cys Arg Ser Gln Pro Cys Arg 
            580                  585                590        
His Gly Gly Lys Cys Leu Asp Leu Val Asp Lys Tyr Leu Cys Arg Cys 
        595                  600                605            
Pro Ser Gly Thr Thr Gly Val Asn Cys Glu Val Asn Ile Asp Asp Cys 
    610                  615                620                
Ala Ser Asn Pro Cys Thr Phe Gly Val Cys Arg Asp Gly Ile Asn Arg 
625                  630                635                  640
Tyr Asp Cys Val Cys Gln Pro Gly Phe Thr Gly Pro Leu Cys Asn Val 
                645                  650                655    
Glu Ile Asn Glu Cys Ala Ser Ser Pro Cys Gly Glu Gly Gly Ser Cys 
            660                  665                670        
Val Asp Gly Glu Asn Gly Phe Arg Cys Leu Cys Pro Pro Gly Ser Leu 
        675                  680                685            
Pro Pro Leu Cys Leu Pro Pro Ser His Pro Cys Ala His Glu Pro Cys 
    690                  695                700                
Ser His Gly Ile Cys Tyr Asp Ala Pro Gly Gly Phe Arg Cys Val Cys 
705                  710                715                  720
Glu Pro Gly Trp Ser Gly Pro Arg Cys Ser Gln Ser Leu Ala Arg Asp 
                725                  730                735    
Ala Cys Glu Ser Gln Pro Cys Arg Ala Gly Gly Thr Cys Ser Ser Asp 
            740                  745                750        
Gly Met Gly Phe His Cys Thr Cys Pro Pro Gly Val Gln Gly Arg Gln 
        755                  760                765            
Cys Glu Leu Leu Ser Pro Cys Thr Pro Asn Pro Cys Glu His Gly Gly 
    770                  775                780                
Arg Cys Glu Ser Ala Pro Gly Gln Leu Pro Val Cys Ser Cys Pro Gln 
785                  790                795                  800
Gly Trp Gln Gly Pro Arg Cys Gln Gln Asp Val Asp Glu Cys Ala Gly 
                805                  810                815    
Pro Ala Pro Cys Gly Pro His Gly Ile Cys Thr Asn Leu Ala Gly Ser 
            820                  825                830        
Phe Ser Cys Thr Cys His Gly Gly Tyr Thr Gly Pro Ser Cys Asp Gln 
        835                  840                845            
Asp Ile Asn Asp Cys Asp Pro Asn Pro Cys Leu Asn Gly Gly Ser Cys 
    850                  855                860                
Gln Asp Gly Val Gly Ser Phe Ser Cys Ser Cys Leu Pro Gly Phe Ala 
865                  870                875                  880
Gly Pro Arg Cys Ala Arg Asp Val Asp Glu Cys Leu Ser Asn Pro Cys 
                885                  890                895    
Gly Pro Gly Thr Cys Thr Asp His Val Ala Ser Phe Thr Cys Thr Cys 
            900                  905                910        
Pro Pro Gly Tyr Gly Gly Phe His Cys Glu Gln Asp Leu Pro Asp Cys 
        915                  920                925            
Ser Pro Ser Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly Val Asn 
    930                  935                940                
Ser Phe Ser Cys Leu Cys Arg Pro Gly Tyr Thr Gly Ala His Cys Gln 
945                  950                955                  960
His Glu Ala Asp Pro Cys Leu Ser Arg Pro Cys Leu His Gly Gly Val 
                965                  970                975    
Cys Ser Ala Ala His Pro Gly Phe Arg Cys Thr Cys Leu Glu Ser Phe 
            980                  985                990        
Thr Gly Pro Gln Cys Gln Thr Leu Val Asp Trp Cys Ser Arg Gln Pro 
        995                  1000                1005            
Cys Gln Asn Gly Gly Arg Cys Val Gln Thr Gly Ala Tyr Cys Leu Cys 
    1010                1015                1020                
Pro Pro Gly Trp Ser Gly Arg Leu Cys Asp Ile Arg Ser Leu Pro Cys 
1025                1030                1035                1040
Arg Glu Ala Ala Ala Gln Ile Gly Val Arg Leu Glu Gln Leu Cys Gln 
                1045                1050                1055    
Ala Gly Gly Gln Cys Val Asp Glu Asp Ser Ser His Tyr Cys Val Cys 
            1060                1065                1070        
Pro Glu Gly Arg Thr Gly Ser His Cys Glu Gln Glu Val Asp Pro Cys 
        1075                1080                1085            
Leu Ala Gln Pro Cys Gln His Gly Gly Thr Cys Arg Gly Tyr Met Gly 
    1090                1095                1100                
Gly Tyr Met Cys Glu Cys Leu Pro Gly Tyr Asn Gly Asp Asn Cys Glu 
1105                1110                1115                1120
Asp Asp Val Asp Glu Cys Ala Ser Gln Pro Cys Gln His Gly Gly Ser 
                1125                1130                1135    
Cys Ile Asp Leu Val Ala Arg Tyr Leu Cys Ser Cys Pro Pro Gly Thr 
            1140                1145                1150        
Leu Gly Val Leu Cys Glu Ile Asn Glu Asp Asp Cys Gly Pro Gly Pro 
        1155                1160                1165            
Pro Leu Asp Ser Gly Pro Arg Cys Leu His Asn Gly Thr Cys Val Asp 
    1170                1175                1180                
Leu Val Gly Gly Phe Arg Cys Thr Cys Pro Pro Gly Tyr Thr Gly Leu 
1185                1190                1195                1200
Arg Cys Glu Ala Asp Ile Asn Glu Cys Arg Ser Gly Ala Cys His Ala 
                1205                1210                1215    
Ala His Thr Arg Asp Cys Leu Gln Asp Pro Gly Gly Gly Phe Arg Cys 
            1220                1225                1230        
Leu Cys His Ala Gly Phe Ser Gly Pro Arg Cys Gln Thr Val Leu Ser 
        1235                1240                1245            
Pro Cys Glu Ser Gln Pro Cys Gln His Gly Gly Gln Cys Arg Pro Ser 
    1250                1255                1260                
Pro Gly Pro Gly Gly Gly Leu Thr Phe Thr Cys His Cys Ala Gln Pro 
1265                1270                1275                1280
Phe Trp Gly Pro Arg Cys Glu Arg Val Ala Arg Ser Cys Arg Glu Leu 
                1285                1290                1295    
Gln Cys Pro Val Gly Val Pro Cys Gln Gln Thr Pro Arg Gly Pro Arg 
            1300                1305                1310        
Cys Ala Cys Pro Pro Gly Leu Ser Gly Pro Ser Cys Arg Ser Phe Pro 
        1315                1320                1325            
Gly Ser Pro Pro Gly Ala Ser Asn Ala Ser Cys Ala Ala Ala Pro Cys 
    1330                1335                1340                
Leu His Gly Gly Ser Cys Arg Pro Ala Pro Leu Ala Pro Phe Phe Arg 
1345                1350                1355                1360
Cys Ala Cys Ala Gln Gly Trp Thr Gly Pro Arg Cys Glu Ala Pro Ala 
                1365                1370                1375    
Ala Ala Pro Glu Val Ser Glu Glu Pro Arg Cys Pro Arg Ala Ala Cys 
            1380                1385                1390        
Gln Ala Lys Arg Gly Asp Gln Arg Cys Asp Arg Glu Cys Asn Ser Pro 
        1395                1400                1405            
Gly Cys Gly Trp Asp Gly Gly Asp Cys Ser Leu Ser Val Gly Asp Pro 
    1410                1415                1420                
Trp Arg Gln Cys Glu Ala Leu Gln Cys Trp Arg Leu Phe Asn Asn Ser 
1425                1430                1435                1440
Arg Cys Asp Pro Ala Cys Ser Ser Pro Ala Cys Leu Tyr Asp Asn Phe 
                1445                1450                1455    
Asp Cys His Ala Gly Gly Arg Glu Arg Thr Cys Asn Pro Val Tyr Glu 
            1460                1465                1470        
Lys Tyr Cys Ala Asp His Phe Ala Asp Gly Arg Cys Asp Gln Gly Cys 
        1475                1480                1485            
Asn Thr Glu Glu Cys Gly Trp Asp Gly Leu Asp Cys Ala Ser Glu Val 
    1490                1495                1500                
Pro Ala Leu Leu Ala Arg Gly Val Leu Val Leu Thr Val Leu Leu Pro 
1505                1510                1515                1520
Pro Glu Glu Leu Leu Arg Ser Ser Ala Asp Phe Leu Gln Arg Leu Ser 
                1525                1530                1535    
Ala Ile Leu Arg Thr Ser Leu Arg Phe Arg Leu Asp Ala His Gly Gln 
            1540                1545                1550        
Ala Met Val Phe Pro Tyr His Arg Pro Ser Pro Gly Ser Glu Pro Arg 
        1555                1560                1565            
Ala Arg Arg Glu Leu Ala Pro Glu Val Ile Gly Ser Val Val Met Leu 
    1570                1575                1580                
Glu Ile Asp Asn Arg Leu Cys Leu Gln Ser Pro Glu Asn Asp His Cys 
1585                1590                1595                1600
Phe Pro Asp Ala Gln Ser Ala Ala Asp Tyr Leu Gly Ala Leu Ser Ala 
                1605                1610                1615    
Val Glu Arg Leu Asp Phe Pro Tyr Pro Leu Arg Asp Val Arg Gly Glu 
            1620                1625                1630        
Pro Leu Glu Pro Pro Glu Pro Ser Val Pro Leu Leu Pro Leu Leu Val 
        1635                1640                1645            
Ala Gly Ala Val Leu Leu Leu Val Ile Leu Val Leu Gly Val Met Val 
    1650                1655                1660                
Ala Arg Arg Lys Arg Glu His Ser Thr Leu Trp Phe Pro Glu Gly Phe 
1665                1670                1675                1680
Ser Leu His Lys Asp Val Ala Ser Gly His Lys Gly Arg Arg Glu Pro 
                1685                1690                1695    
Val Gly Gln Asp Ala Leu Gly Met Lys Asn Met Ala Lys Gly Glu Ser 
            1700                1705                1710        
Leu Met Gly Glu Val Ala Thr Asp Trp Met Asp Thr Glu Cys Pro Glu 
        1715                1720                1725            
Ala Lys Arg Leu Lys Val Glu Glu Pro Gly Met Gly Ala Glu Glu Ala 
    1730                1735                1740                
Val Asp Cys Arg Gln Trp Thr Gln His His Leu Val Ala Ala Asp Ile 
1745                1750                1755                1760
Arg Val Ala Pro Ala Met Ala Leu Thr Pro Pro Gln Gly Asp Ala Asp 
                1765                1770                1775    
Ala Asp Gly Met Asp Val Asn Val Arg Gly Pro Asp Gly Phe Thr Pro 
            1780                1785                1790        
Leu Met Leu Ala Ser Phe Cys Gly Gly Ala Leu Glu Pro Met Pro Thr 
        1795                1800                1805            
Glu Glu Asp Glu Ala Asp Asp Thr Ser Ala Ser Ile Ile Ser Asp Leu 
    1810                1815                1820                
Ile Cys Gln Gly Ala Gln Leu Gly Ala Arg Thr Asp Arg Thr Gly Glu 
1825                1830                1835                1840
Thr Ala Leu His Leu Ala Ala Arg Tyr Ala Arg Ala Asp Ala Ala Lys 
                1845                1850                1855    
Arg Leu Leu Asp Ala Gly Ala Asp Thr Asn Ala Gln Asp His Ser Gly 
            1860                1865                1870        
Arg Thr Pro Leu His Thr Ala Val Thr Ala Asp Ala Gln Gly Val Phe 
        1875                1880                1885            
Gln Ile Leu Ile Arg Asn Arg Ser Thr Asp Leu Asp Ala Arg Met Ala 
    1890                1895                1900                
Asp Gly Ser Thr Ala Leu Ile Leu Ala Ala Arg Leu Ala Val Glu Gly 
1905                1910                1915                1920
Met Val Glu Glu Leu Ile Ala Ser His Ala Asp Val Asn Ala Val Asp 
                1925                1930                1935    
Glu Leu Gly Lys Ser Ala Leu His Trp Ala Ala Ala Val Asn Asn Val 
            1940                1945                1950        
Glu Ala Thr Leu Ala Leu Leu Lys Asn Gly Ala Asn Lys Asp Met Gln 
        1955                1960                1965            
Asp Ser Lys Glu Glu Thr Pro Leu Phe Leu Ala Ala Arg Glu Gly Ser 
    1970                1975                1980                
Tyr Glu Ala Ala Lys Leu Leu Leu Asp His Phe Ala Asn Arg Glu Ile 
1985                1990                1995                2000
Thr Asp His Leu Asp Arg Leu Pro Arg Asp Val Ala Gln Glu Arg Leu 
                2005                2010                2015    
His Gln Asp Ile Val Arg Leu Leu Asp Gln Pro Ser Gly Pro Arg Ser 
            2020                2025                2030        
Pro Pro Gly Pro His Gly Leu Gly Pro Leu Leu Cys Pro Pro Gly Ala 
        2035                2040                2045            
Phe Leu Pro Gly Leu Lys Ala Ala Gln Ser Gly Ser Lys Lys Ser Arg 
    2050                2055                2060                
Arg Pro Pro Gly Lys Ala Gly Leu Gly Pro Gln Gly Pro Arg Gly Arg 
2065                2070                2075                2080
Gly Lys Lys Leu Thr Leu Ala Cys Pro Gly Pro Leu Ala Asp Ser Ser 
                2085                2090                2095    
Val Thr Leu Ser Pro Val Asp Ser Leu Asp Ser Pro Arg Pro Phe Gly 
            2100                2105                2110        
Gly Pro Pro Ala Ser Pro Gly Gly Phe Pro Leu Glu Gly Pro Tyr Ala 
        2115                2120                2125            
Ala Ala Thr Ala Thr Ala Val Ser Leu Ala Gln Leu Gly Gly Pro Gly 
    2130                2135                2140                
Arg Ala Gly Leu Gly Arg Gln Pro Pro Gly Gly Cys Val Leu Ser Leu 
2145                2150                2155                2160
Gly Leu Leu Asn Pro Val Ala Val Pro Leu Asp Trp Ala Arg Leu Pro 
                2165                2170                2175    
Pro Pro Ala Pro Pro Gly Pro Ser Phe Leu Leu Pro Leu Ala Pro Gly 
            2180                2185                2190        
Pro Gln Leu Leu Asn Pro Gly Thr Pro Val Ser Pro Gln Glu Arg Pro 
        2195                2200                2205            
Pro Pro Tyr Leu Ala Val Pro Gly His Gly Glu Glu Tyr Pro Ala Ala 
    2210                2215                2220                
Gly Ala His Ser Ser Pro Pro Lys Ala Arg Phe Leu Arg Val Pro Ser 
2225                2230                2235                2240
Glu His Pro Tyr Leu Thr Pro Ser Pro Glu Ser Pro Glu His Trp Ala 
                2245                2250                2255    
Ser Pro Ser Pro Pro Ser Leu Ser Asp Trp Ser Glu Ser Thr Pro Ser 
            2260                2265                2270        
Pro Ala Thr Ala Thr Gly Ala Met Ala Thr Thr Thr Gly Ala Leu Pro 
        2275                2280                2285            
Ala Gln Pro Leu Pro Leu Ser Val Pro Ser Ser Leu Ala Gln Ala Gln 
    2290                2295                2300                
Thr Gln Leu Gly Pro Gln Pro Glu Val Thr Pro Lys Arg Gln Val Leu 
2305                2310                2315                2320
Ala 
    

